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Hui Teng, Lei Chen
Based on many cell culture, animal and human studies, it is well known that the most challenge issue for developing polyphenolics as chemoprevention or anti-diabtetic agents is the low oral bioavailability, which may be the major reason relating to its ambiguous therapeutic effects and large inter-individual variations in clinical trials. This review intends to highlight the unscientific evaluation on the basis of the published data regarding in vitro bioactivity of polyphenols, which may sometimes mislead the researchers and to conclude that: first, bio-accessibilities values obtained in the studies for polyphenols should be highly reconsidered in accordance with the abundant newly identified circulating and excreted metabolites, with a particular attention to colonic metabolic products which are obviously contributing much more than expected to their absorptions; second, it is phenolic metabolites, which are formed in the small intestine and hepatic cells,low molecular weight catabolic products of the colonic microflora to travel around the human body in the circulatory system or reach body tissues to elicit bioactive effects...
February 6, 2018: Critical Reviews in Food Science and Nutrition
No abstract text is available yet for this article.
January 19, 1959: Polski Tygodnik Lekarski
X Guangda, W Yuhua
AIMS/HYPOTHESIS: Several studies have suggested a predisposing role of the e4 allele of apolipoprotein E (ApoE) in the development of atherosclerosis and cardiovascular disease in Type 2 diabetes. Therefore, we hypothesized that the e4 allele is also a risk factor for endothelial dysfunction. We attempted to assess whether Apo e4 allele is associated with endothelial dysfunction in the early stage of Type 2 diabetes. METHODS: We selected 255 Chinese Han Type 2 diabtetic men without angiopathy...
April 2003: Diabetologia
W Gepts
From a morphological point of view, two distinct pathological pictures emerge in the common types of human diabtetes. The first is characterized in the initial phase of the disease by inflammatory lesions in the islets of Langerhans. These lead to fibrosis and apparent atrophy of the islets, which in a more advanced stage are composed of non-insulin-producing cells, the B-cells having been largely destroyed. This picture is specific and diagnostic for the classical insulin-dependent type of diabetes, which occurs more often in young individuals...
May 1980: Annales D'endocrinologie
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