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FAAH and epilepsy

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https://www.readbyqxmd.com/read/27790143/a-personal-retrospective-elevating-anandamide-aea-by-targeting-fatty-acid-amide-hydrolase-faah-and-the-fatty-acid-binding-proteins-fabps
#1
Dale G Deutsch
This perspective was adapted from a Career Achievement Award talk given at the International Cannabinoid Research Society Symposium in Bukovina, Poland on June 27, 2016. As a biochemist working in the neurosciences, I was always fascinated with neurotransmitter inactivation. In 1993 we identified an enzyme activity that breaks down anandamide. We called the enzyme anandamide amidase, now called FAAH. We and other laboratories developed FAAH inhibitors that were useful reagents that also proved to have beneficial physiological effects and until recently, new generations of inhibitors were in clinical trials...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27086601/endocannabinoid-system-a-multi-facet-therapeutic-target
#2
REVIEW
Rimplejeet Kaur, Sneha R Ambwani, Surjit Singh
Cannabis sativa is also popularly known as marijuana. It has been cultivated and used by man for recreational and medicinal purposes since many centuries. Study of cannabinoids was at bay for very long time and its therapeutic value could not be adequately harnessed due to its legal status as proscribed drug in most of the countries. The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve "protective role" in many medical conditions...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/25666611/fatty-acid-binding-proteins-fabps-are-intracellular-carriers-for-%C3%AE-9-tetrahydrocannabinol-thc-and-cannabidiol-cbd
#3
Matthew W Elmes, Martin Kaczocha, William T Berger, KwanNok Leung, Brian P Ralph, Liqun Wang, Joseph M Sweeney, Jeremy T Miyauchi, Stella E Tsirka, Iwao Ojima, Dale G Deutsch
Δ(9)-Tetrahydrocannabinol (THC) and cannabidiol (CBD) occur naturally in marijuana (Cannabis) and may be formulated, individually or in combination in pharmaceuticals such as Marinol or Sativex. Although it is known that these hydrophobic compounds can be transported in blood by albumin or lipoproteins, the intracellular carrier has not been identified. Recent reports suggest that CBD and THC elevate the levels of the endocannabinoid anandamide (AEA) when administered to humans, suggesting that phytocannabinoids target cellular proteins involved in endocannabinoid clearance...
April 3, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/24674273/anticonvulsant-effects-of-n-arachidonoyl-serotonin-a-dual-fatty-acid-amide-hydrolase-enzyme-and-transient-receptor-potential-vanilloid-type-1-trpv1-channel-blocker-on-experimental-seizures-the-roles-of-cannabinoid-cb1-receptors-and-trpv1-channels
#4
Luciano R Vilela, Daniel C Medeiros, Antonio Carlos P de Oliveira, Marcio F Moraes, Fabricio A Moreira
Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 channels, generally with an opposite outcome on neuronal modulation. Thus, we suggested that the dual FAAH and TRPV1 blockade with N-arachidonoyl-serotonin (AA-5-HT) would be efficacious in inhibiting pentylenetetrazole (PTZ)-induced seizures in mice. We also investigated the contribution of CB1 activation and TRPV1 blockade to the overt effect of AA-5-HT...
October 2014: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/22625422/cannabidiol-for-neurodegenerative-disorders-important-new-clinical-applications-for-this-phytocannabinoid
#5
REVIEW
Javier Fernández-Ruiz, Onintza Sagredo, M Ruth Pazos, Concepción García, Roger Pertwee, Raphael Mechoulam, José Martínez-Orgado
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anxiolytic and antipsychotic agent, and is therefore a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia, respectively. The neuroprotective potential of CBD, based on the combination of its anti-inflammatory and anti-oxidant properties, is of particular interest and is presently under intense preclinical research in numerous neurodegenerative disorders...
February 2013: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/15923084/fatty-acid-amidohydrolase-in-human-neocortex-activity-in-epileptic-and-non-epileptic-brain-tissue-and-inhibition-by-putative-endocannabinoids
#6
COMPARATIVE STUDY
Marc Steffens, Andreas Schulze-Bonhage, Rainer Surges, Thomas J Feuerstein
Increased levels of the endocannabinoid anandamide (AEA) have been observed in connection with neuronal disorders like epilepsy. In order to investigate whether an impaired enzymatic AEA hydrolysis contributes to this phenomenon, the present study determined the activity of fatty acid amidohydrolase (FAAH) in epileptic and non-epileptic human neocortical brain tissue. Additionally, we investigated whether other putative endocannabinoids (2-arachidonylglycerol (2-AG), noladin ether, virodhamine) may also interact with FAAH...
September 2, 2005: Neuroscience Letters
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