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https://www.readbyqxmd.com/read/27915343/intravitreal-dexamethasone-implant-for-the-treatment-of-postoperative-macular-edema
#1
André Klamann, Katharina Böttcher, Philipp Ackermann, Gerd Geerling, Marc Schargus, Rainer Guthoff
INTRODUCTION: Macular edema after cataract surgery (Irvine-Gass syndrome) or pars plana vitrectomy is a postoperative complication which can lead to permanent visual loss. Increased inflammatory substances, such as prostaglandins and cytokines, are discussed to be causative. Currently, there are no evidence-based guidelines for the treatment of postoperative macular edema. Intravitreal dexamethasone (DEX) could be effective by its anti-inflammatory effect. We examined the functional and morphological results of treatment with 0...
December 3, 2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27915077/how-do-government-regulations-influence-the-ability-to-practice-chinese-herbal-medicine-in-western-countries
#2
Tom Fleischer, Yi-Chang Su, Sunny Jui-Shan Lin
ETHNOPHARMACOLOGICAL RELEVANCE: The regulation policies of substances used in Chinese Herbal Medicine (CHM), have a direct influence on the ability of health providers to practice in the clinic. AIM OF THE STUDY: We set out to assess the truth behind the assumption that practice of CHM in the west is constrained by the regulations imposed by authorities in western countries. MATERIALS AND METHODS: For the first part of our study we surveyed and compiled lists of banned and restricted Chinese Materia Medica (CMM) from six countries: USA, UK, Germany, Israel, Canada and Australia...
November 30, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27914971/once-weekly-ofatumumab-in-untreated-or-relapsed-waldenstr%C3%A3-m-s-macroglobulinaemia-an-open-label-single-arm-phase-2-study
#3
Richard R Furman, Herbert A Eradat, Christine G DiRienzo, Craig C Hofmeister, Suzanne R Hayman, John P Leonard, Morton Coleman, Ranjana Advani, Asher Chanan-Khan, Julie Switzky, Qiming M Liao, Damini Shah, Roxanne C Jewell, Steen Lisby, Thomas S Lin
BACKGROUND: The development of more effective and safer treatments, especially non-chemotherapeutics, is needed for patients with Waldenström's macroglobulinaemia. The aim of the study was to assess the safety and clinical activity of intravenous ofatumumab monotherapy for untreated and relapsed Waldenström's macroglobulinaemia. METHODS: We did a phase 2, open-label, single-arm study at six centres (hospitals and cancer clinics) in the USA. Patients aged at least 18 years who were diagnosed with untreated or relapsed Waldenström's macroglobulinaemia and required treatment, received up to three cycles of weekly ofatumumab for 5 weeks...
November 30, 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27843506/promotion-of-nickel-ni-allergy-by-anamnestic-sensitization-with-a-bacterial-component-lipopolysaccharide-lps-in-mice
#4
Norimasa Adachi, Eiji Takayama, Makoto Adachi, Masako Mizuno-Kamiya, Harumi Kawaki, Hiroko Takeuchi, Shuri Kubo, Hajime Ishigami, Masakazu Kurachi, Nobuo Kondoh
BACKGROUND/OBJECTIVE: Lipopolysaccharides (LPS) promote allergic responses to nickel (Ni) both in the sensitization and elicitation steps. In this study, we examine the effect of pre-sensitization to LPS on the occurrence of Ni allergy using a mouse model. METHOD: A 100 mg of LPS was injected into C57BL/6J mice intraperitoneally (ip). Three weeks later, the mice were subsequently injected with 0.3 μ moles of nickel dichloride (NiCl2) and 100 μg of CpG-DNA, which acted as an adjuvant...
2016: Open Dentistry Journal
https://www.readbyqxmd.com/read/27836716/activity-and-safety-of-brigatinib-in-alk-rearranged-non-small-cell-lung-cancer-and-other-malignancies-a-single-arm-open-label-phase-1-2-trial
#5
Scott N Gettinger, Lyudmila A Bazhenova, Corey J Langer, Ravi Salgia, Kathryn A Gold, Rafael Rosell, Alice T Shaw, Glen J Weiss, Meera Tugnait, Narayana I Narasimhan, David J Dorer, David Kerstein, Victor M Rivera, Timothy Clackson, Frank G Haluska, David Ross Camidge
BACKGROUND: Anaplastic lymphoma kinase (ALK) gene rearrangements are oncogenic drivers of non-small-cell lung cancer (NSCLC). Brigatinib (AP26113) is an investigational ALK inhibitor with potent preclinical activity against ALK mutants resistant to crizotinib and other ALK inhibitors. We aimed to assess brigatinib in patients with advanced malignancies, particularly ALK-rearranged NSCLC. METHODS: In this ongoing, single-arm, open-label, phase 1/2 trial, we recruited patients from nine academic hospitals or cancer centres in the USA and Spain...
November 7, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27809237/discovery-of-bioactive-compounds-by-the-uic-icbg-drug-discovery-program-in-the-18-years-since-1998
#6
REVIEW
Hong-Jie Zhang, Wan-Fei Li, Harry H S Fong, Djaja Doel Soejarto
The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria...
October 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27807299/public-health-benefits-from-pictorial-health-warnings-on-us-cigarette-packs-a-simsmoke-simulation
#7
David T Levy, Darren Mays, Zhe Yuan, David Hammond, James F Thrasher
INTRODUCTION: While many countries have adopted prominent pictorial warning labels (PWLs) for cigarette packs, the USA still requires only small, text-only labels located on one side of the cigarette pack that have little effect on smoking-related outcomes. Tobacco industry litigation blocked implementation of a 2011 Food and Drug Administration's (FDA) rule requiring large PWLs. To inform FDA action on PWLs, this study provides research-based estimates of their public health impacts...
November 2, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27754046/os-14-03-cardiovascular-risk-markers-in-korean-ethnicity-migrants-of-2-3rd-generation-living-in-sakhalin-region
#8
Nina Repina, Tatiana Brodskaya, Vera Nevzorova, Margarita Моkshinа, Evgeniy Аbramov
OBJECTIVE: In conditions of existing immigration flows, the special relevance has researches concerning cardiovascular risk stratification among of different ethnic origin patients living outside the traditional habitats. DESIGN AND METHOD: 180 residents of Sakhalin region with arterial hypertension (AG) I-III degree, I-II stage, 88 Korean ethnicity patients, migrants of 2-3-rd generation, 92 Slavic ethnicity patients (58,2 ± 0,93 years old) were examined. The common risk factors and left ventricle (LV) structural-functional characteristics (Echocardiograph Aсuson X-300 HP, USA) were analyzed...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27702705/robotic-assisted-reconstruction-of-cervix-and-vagina-by-sis-graft-and-fusion-of-hemi-uterus
#9
Ying Zhang, Yisong Chen, Keqin Hua
STUDY OBJECTIVE: To describe our technique of robotic assisted reconstruction of cervix and vagina by SIS (small intestinal sub-mucosa, SIS) graft and fusion of hemi-uterus. DESIGN: Step-by-step explanation of the procedure using video. SETTING: Congenital complete vaginal and cervical atresia is rare. Some patient has urinary system abnormality. No standardized surgical treatment guideline was available and the performance is varying for each patient...
October 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27672336/lyme-disease-the-promise-of-big-data-companion-diagnostics-and-precision-medicine
#10
Raphael B Stricker, Lorraine Johnson
Lyme disease caused by the spirochete Borrelia burgdorferi has become a major worldwide epidemic. Recent studies based on Big Data registries show that >300,000 people are diagnosed with Lyme disease each year in the USA, and up to two-thirds of individuals infected with B. burgdorferi will fail conventional 30-year-old antibiotic therapy for Lyme disease. In addition, animal and human evidence suggests that sexual transmission of the Lyme spirochete may occur. Improved companion diagnostic tests for Lyme disease need to be implemented, and novel treatment approaches are urgently needed to combat the epidemic...
2016: Infection and Drug Resistance
https://www.readbyqxmd.com/read/27661788/patient-centered-methadone-treatment-a-randomized-clinical-trial
#11
Robert P Schwartz, Sharon M Kelly, Shannon G Mitchell, Jan Gryczynski, Kevin E O'Grady, Devang Gandhi, Yngvild Olsen, Jerome H Jaffe
BACKGROUND AND AIMS: Methadone patients who discontinue treatment are at high risk of relapse, yet a substantial proportion discontinue treatment within the first year. We investigated whether a patient-centered approach to methadone treatment improved participant outcomes at 12 months following admission, compared with methadone treatment-as-usual. DESIGN: Two-arm open-label randomized trial. SETTING: Two methadone treatment programs (MTPs) in Baltimore, MD, USA...
September 23, 2016: Addiction
https://www.readbyqxmd.com/read/27658870/association-of-age-baseline-kidney-function-and-medication-exposure-with-declines-in-creatinine-clearance-on-pre-exposure-prophylaxis-an-observational-cohort-study
#12
Monica Gandhi, David V Glidden, Kenneth Mayer, Mauro Schechter, Susan Buchbinder, Beatriz Grinsztejn, Sybil Hosek, Martin Casapia, Juan Guanira, Linda-Gail Bekker, Alexander Louie, Howard Horng, Leslie Z Benet, Albert Liu, Robert M Grant
BACKGROUND: As pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine for the prevention of HIV infection is rolled out internationally, strategies to maintain effectiveness and to minimise adverse effects merit consideration. In this study, we aimed to assess reductions in renal function and predictors of renal toxicity in a large open-label study of PrEP. METHODS: As part of the iPrEx open-label extension (OLE) study, men who have sex with men or transgender women aged 18-70 years who were HIV negative and had participated in three previous PrEP trials from Brazil, Ecuador, Peru, South Africa, Thailand, and the USA were enrolled into an open-label PrEP study...
November 2016: Lancet HIV
https://www.readbyqxmd.com/read/27642966/os-14-03-cardiovascular-risk-markers-in-korean-ethnicity-migrants-of-2-3rd-generation-living-in-sakhalin-region
#13
Nina Repina, Tatiana Brodskaya, Vera Nevzorova, Margarita Моkshinа, Evgeniy Аbramov
OBJECTIVE: In conditions of existing immigration flows, the special relevance has researches concerning cardiovascular risk stratification among of different ethnic origin patients living outside the traditional habitats. DESIGN AND METHOD: 180 residents of Sakhalin region with arterial hypertension (AG) I-III degree, I-II stage, 88 Korean ethnicity patients, migrants of 2-3-rd generation, 92 Slavic ethnicity patients (58,2 ± 0,93 years old) were examined. The common risk factors and left ventricle (LV) structural-functional characteristics (Echocardiograph Aсuson X-300 HP, USA) were analyzed...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27637966/sickle-cell-disease
#14
J Strouse
Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a mutation in the sixth amino acid of the β-globin gene (HBB). It is the most common serious genetic diseases in childhood, affecting approximately 1 in 2500 births and 100 000 individuals in the USA, in addition to 300 000 new cases globally each year. Central nervous system injury is the most debilitating frequent complication of SCD and includes stroke, silent cerebral infarct (SCI), and cognitive impairment. Among children with sickle cell anemia (HbSS), 11% had a stroke by age 18 years before the implementation of transcranial Doppler screening...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27637340/predicting-the-effect-of-maternal-docosahexaenoic-acid-dha-supplementation-to-reduce-early-preterm-birth-in-australia-and-the-united-states-using-results-of-within-country-randomized-controlled-trials
#15
L N Yelland, B J Gajewski, J Colombo, R A Gibson, M Makrides, S E Carlson
The DHA to Optimize Mother Infant Outcome (DOMInO) and Kansas DHA Outcomes Study (KUDOS) were randomized controlled trials that supplemented mothers with 800 and 600mg DHA/day, respectively, or a placebo during pregnancy. DOMInO was conducted in Australia and KUDOS in the United States. Both trials found an unanticipated and statistically significant reduction in early preterm birth (ePTB; i.e., birth before 34 weeks gestation). However, in each trial, the number of ePTBs were small. We used a novel Bayesian approach to estimate statistically derived low, moderate or high risk for ePTB, and to test for differences between the DHA and placebo groups...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27625444/comparative-study-of-clinico-bacterio-radiological-profile-and-treatment-outcome-of-smokers-and-nonsmokers-suffering-from-pulmonary-tuberculosis
#16
Deepti Rathee, Piyush Arora, Manoj Meena, Rohit Sarin, Pitambar Chakraborty, Anand Jaiswal, Mukesh Goyal
INTRODUCTION: Tuberculosis (TB) is one of the leading causes of death and disease worldwide. Tobacco smoking has been linked as a risk factor for TB. This study was aimed to affirm the strength of association between smoking and pulmonary TB. MATERIALS AND METHODS: Pulmonary TB patients aged between 18 and 65 years were enrolled and followed-up until treatment completion. Two consecutive sputum smears were examined from each patient for the presence of acid-fast bacilli (AFB) using Ziehl-Neelsen technique...
September 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27624598/long-lasting-effects-of-adolescent-oxycodone-exposure-on-reward-related-behavior-and-gene-expression-in-mice
#17
Victoria Sanchez, Marco D Carpenter, Nicole L Yohn, Julie A Blendy
RATIONALE: Prescription opioid abuse and transition to heroin use are growing problems in the USA. However, the long-term consequences of adolescent prescription opioid abuse on subsequent drug use and affective-like behavior are unknown. OBJECTIVES: This study aims to determine if adolescent exposure to oxycodone alters the rewarding effects of morphine, anxiety-like behavior, and reward-related gene expression later in adulthood. METHODS: Adolescent male C57Bl/6 mice were exposed to oxycodone (3 mg/kg/day) via osmotic minipumps for 28 days...
September 13, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27619773/impact-of-gonadotropin-type-on-progesterone-elevation-during-ovarian-stimulation-in-gnrh-antagonist-cycles
#18
B Lawrenz, F Beligotti, N Engelmann, D Gates, H M Fatemi
STUDY QUESTION: Does hormonal stimulation with corifollitropin alpha (CFA) only, mimicking a step down protocol, result in lower incidence of progesterone elevation on the day of hCGtrigger as compared to sustained stimulation with recombinant FSH (rFSH)? SUMMARY ANSWER: The current findings support the concept that sustained FSH stimulus contributes to premature progesterone elevation in stimulated IVF cycles. WHAT IS KNOWN ALREADY: Serum progesterone rise during the follicular phase of ovarian stimulation for IVF treatment seems to be related to a poorer reproductive outcome...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27599568/silver-nanoparticles-modified-biomaterial-surface-resistant-to-staphylococcus-new-insight-into-the-antimicrobial-action-of-silver
#19
Jiaxing Wang, Jinhua Li, Geyong Guo, Qiaojie Wang, Jin Tang, Yaochao Zhao, Hui Qin, Tuerhongjiang Wahafu, Hao Shen, Xuanyong Liu, Xianlong Zhang
Titanium implants are widely used clinically, but postoperative implant infection remains a potential severe complication. The purpose of this study was to investigate the antibacterial activity of nano-silver(Ag)-functionalized Ti surfaces against epidemic Staphylococcus from the perspective of the regulation of biofilm-related genes and based on a bacteria-cell co-culture study. To achieve this goal, two representative epidemic Staphylococcus strains, Staphylococcus epidermidis (S. epidermidis, RP62A) and Staphylococcus aureus (S...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27570087/ofatumumab-monotherapy-as-a-consolidation-strategy-in-patients-with-previously-untreated-chronic-lymphocytic-leukaemia-a-phase-2-trial
#20
Paolo Strati, Mark Lanasa, Timothy G Call, Jose F Leis, Danielle M Brander, Betsy R LaPlant, Adam M Pettinger, Wei Ding, Sameer A Parikh, Curtis A Hanson, Asher A Chanan-Khan, Deborah A Bowen, Michael Conte, Neil E Kay, Tait D Shanafelt
BACKGROUND: Although several consolidation strategies to prolong treatment-free survival (TFS) in chronic lymphocytic leukaemia have been investigated, most have proven either ineffective or toxic. Ofatumumab is a human type I anti-CD20 antibody approved by the US Food and Drug Administration as maintenance treatment of patients with recurrent or progressive chronic lymphocytic leukaemia who are in complete or partial response after at least two lines of treatment; higher efficacy might be observed if used as consolidation strategy than without consolidation in previously untreated patients...
September 2016: Lancet Haematology
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