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https://www.readbyqxmd.com/read/28050669/usa300-a-strain-of-community-associated-methicillin-resistant-staphylococcus-aureus-crossing-belgium-s-borders-outbreak-of-skin-and-soft-tissue-infections-in-a-hospital-in-belgium
#1
K Kaïret, E Ho, D Van Kerkhoven, J Boes, S Van Calenbergh, L Pattyn, P Lemay
OBJECTIVE: to investigate an outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 in a hospital setting, and the effect of infection control measures. DESIGN: outbreak investigation and retrospective chart review. SETTING: local inpatient and outpatient clinic. PATIENTS: all patients with a history of skin and soft tissue infections with culture-confirmed methicillin-resistant Staphylococcus aureus USA 300 infection from September, 2014, through June, 2015...
January 3, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28045313/parental-knowledge-and-practices-regarding-their-children-s-oral-health-in-kuwait
#2
L Alyahya
AIM: The purpose of this study is to assess the knowledge and practices of parents toward their children's oral health in Kuwait. MATERIALS AND METHODS: Study Design: A cross-sectional study was conducted among 300 parents who visited five dental specialty centers in Kuwait. Data were collected through a self-administered questionnaire. STATISTICS: The statistical analysis was performed using SPSS software (version 21; Inc., Chicago IL, USA)...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28043157/complete-nucleotide-sequence-analysis-of-the-oncogene-meq-from-serotype-1-marek-s-disease-virus-isolates-from-india
#3
P Suresh, J Johnson Rajeswar, K Sukumar, T J Harikrishnan, P Srinivasan
1. A study was undertaken to characterise the oncogene Meq at the molecular level for three serotype 1 Marek's disease virus (MDV) field isolates from vaccinated poultry flocks which had encountered a Marek's disease outbreak in the southern part of India. The isolates were named Ind/TN/11/01, Ind/KA/12/02 and Ind/TN/12/03. The oncogene Meq was amplified by PCR and sequenced. 2. The isolates were shown to have a homology for the Meq gene of 99.1-99.8% with various isolates from China and 98.5-99.2% with isolates from Europe and the USA...
January 18, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28028914/a-systematic-review-of-pregnancy-exposure-registries-examination-of-protocol-specified-pregnancy-outcomes-target-sample-size-and-comparator-selection
#4
Kate Gelperin, Hoda Hammad, Kira Leishear, Steven T Bird, Lockwood Taylor, Christian Hampp, Leyla Sahin
PURPOSE: Our study sought to systematically evaluate protocol-specified study methodology in prospective pregnancy exposure registries including pre-specified pregnancy outcomes, power calculations for sample size, and comparator group selection. METHODS: U.S. pregnancy exposure registries designed to evaluate safety of drugs or biologics were identified from www.clinicaltrials.gov, the FDA's Office of Women's Health website, and the FDA's list of postmarketing studies...
December 27, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28000041/continuous-blood-pressure-monitoring-via-non-invasive-radial-artery-applanation-tonometry-and-invasive-arterial-catheter-demonstrates-good-agreement-in-patients-undergoing-colon-carcinoma-surgery
#5
Jing Sun, Hanjian Chen, Jun Zheng, Bin Mao, Shengmei Zhu, Jingyi Feng
PURPOSE: Radial artery applanation tonometry (RAAT) has been developed and utilized for continuous arterial pressure monitoring. However, evidence is lacking to clinically verify the RAAT technology and identify appropriate patient groups before routine clinical use. This study aims to evaluate the RAAT technology by comparing systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP) values in patients undergoing colon carcinoma surgery. METHODS: Blood Pressure (BP) values obtained via RAAT (TL-300, Tensys Medical Inc...
December 20, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27990844/artificial-heart-pumps-bridging-the-gap-between-science-technology-and-personalized-medicine-by-relational-medicine
#6
Federica Raia, Mario C Deng
In the US population of 300 million, 3 million have heart failure with reduced ejection fraction and 300,000 have advanced heart failure. Long-term mechanical circulatory support will, within the next decade, be recommended to 30,000 patients annually in the USA, 3000 undergo heart transplantation annually. What do these advances mean for persons suffering from advanced heart failure and their loved ones/caregivers? In this perspective article, we discuss - by exemplifying a case report of a 27-year-old man receiving a Total Artificial Heart - a practice concept of modern medicine that fully incorporates the patient's personhood perspective which we have termed Relational Medicine™...
January 2017: Future Cardiology
https://www.readbyqxmd.com/read/27932005/estimating-community-level-costs-of-preterm-birth
#7
E S Hall, J M Greenberg
OBJECTIVES: To develop generalizable methods for estimating the economic impact of preterm birth at the community level on initial hospital expenditures, educational attainment and lost earnings as well as to estimate potential savings associated with reductions in preterm birth. STUDY DESIGN: The retrospective, population-based analysis used vital statistics and population demographics from Hamilton County, Ohio, USA, in 2012. METHODS: We adjusted previously reported, mean initial hospital cost estimates (stratified by each week of gestation) to 2012 dollars using national cost-to-charge ratios...
December 2016: Public Health
https://www.readbyqxmd.com/read/27923385/field-effectiveness-of-microbial-larvicides-on-mosquito-larvae-in-malaria-areas-of-botswana-and-zimbabwe
#8
Mulamuli Mpofu, Piet Becker, Kaka Mudambo, Christiaan de Jager
BACKGROUND: The successful control of malaria vectors requires the control of both the larval and adult stages. The adult control methods through indoor residual spraying (IRS) and use of long-lasting insecticidal nets (LLINs) continue to be widely used with some high measure of success. Larval control methods are also being used by a number of National Malaria Control Programmes (NMCPs) with limited understanding of its contribution. Larval control might be needed in some areas to move from malaria control to elimination...
December 6, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27915343/intravitreal-dexamethasone-implant-for-the-treatment-of-postoperative-macular-edema
#9
André Klamann, Katharina Böttcher, Philipp Ackermann, Gerd Geerling, Marc Schargus, Rainer Guthoff
INTRODUCTION: Macular edema after cataract surgery (Irvine-Gass syndrome) or pars plana vitrectomy is a postoperative complication which can lead to permanent visual loss. Increased inflammatory substances, such as prostaglandins and cytokines, are discussed to be causative. Currently, there are no evidence-based guidelines for the treatment of postoperative macular edema. Intravitreal dexamethasone (DEX) could be effective by its anti-inflammatory effect. We examined the functional and morphological results of treatment with 0...
2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27915077/how-do-government-regulations-influence-the-ability-to-practice-chinese-herbal-medicine-in-western-countries
#10
Tom Fleischer, Yi-Chang Su, Sunny Jui-Shan Lin
ETHNOPHARMACOLOGICAL RELEVANCE: The regulation policies of substances used in Chinese Herbal Medicine (CHM), have a direct influence on the ability of health providers to practice in the clinic. AIM OF THE STUDY: We set out to assess the truth behind the assumption that practice of CHM in the west is constrained by the regulations imposed by authorities in western countries. MATERIALS AND METHODS: For the first part of our study we surveyed and compiled lists of banned and restricted Chinese Materia Medica (CMM) from six countries: USA, UK, Germany, Israel, Canada and Australia...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27914971/once-weekly-ofatumumab-in-untreated-or-relapsed-waldenstr%C3%A3-m-s-macroglobulinaemia-an-open-label-single-arm-phase-2-study
#11
Richard R Furman, Herbert A Eradat, Christine G DiRienzo, Craig C Hofmeister, Suzanne R Hayman, John P Leonard, Morton Coleman, Ranjana Advani, Asher Chanan-Khan, Julie Switzky, Qiming M Liao, Damini Shah, Roxanne C Jewell, Steen Lisby, Thomas S Lin
BACKGROUND: The development of more effective and safer treatments, especially non-chemotherapeutics, is needed for patients with Waldenström's macroglobulinaemia. The aim of the study was to assess the safety and clinical activity of intravenous ofatumumab monotherapy for untreated and relapsed Waldenström's macroglobulinaemia. METHODS: We did a phase 2, open-label, single-arm study at six centres (hospitals and cancer clinics) in the USA. Patients aged at least 18 years who were diagnosed with untreated or relapsed Waldenström's macroglobulinaemia and required treatment, received up to three cycles of weekly ofatumumab for 5 weeks...
January 2017: Lancet Haematology
https://www.readbyqxmd.com/read/27843506/promotion-of-nickel-ni-allergy-by-anamnestic-sensitization-with-a-bacterial-component-lipopolysaccharide-lps-in-mice
#12
Norimasa Adachi, Eiji Takayama, Makoto Adachi, Masako Mizuno-Kamiya, Harumi Kawaki, Hiroko Takeuchi, Shuri Kubo, Hajime Ishigami, Masakazu Kurachi, Nobuo Kondoh
BACKGROUND/OBJECTIVE: Lipopolysaccharides (LPS) promote allergic responses to nickel (Ni) both in the sensitization and elicitation steps. In this study, we examine the effect of pre-sensitization to LPS on the occurrence of Ni allergy using a mouse model. METHOD: A 100 mg of LPS was injected into C57BL/6J mice intraperitoneally (ip). Three weeks later, the mice were subsequently injected with 0.3 μ moles of nickel dichloride (NiCl2) and 100 μg of CpG-DNA, which acted as an adjuvant...
2016: Open Dentistry Journal
https://www.readbyqxmd.com/read/27836716/activity-and-safety-of-brigatinib-in-alk-rearranged-non-small-cell-lung-cancer-and-other-malignancies-a-single-arm-open-label-phase-1-2-trial
#13
Scott N Gettinger, Lyudmila A Bazhenova, Corey J Langer, Ravi Salgia, Kathryn A Gold, Rafael Rosell, Alice T Shaw, Glen J Weiss, Meera Tugnait, Narayana I Narasimhan, David J Dorer, David Kerstein, Victor M Rivera, Timothy Clackson, Frank G Haluska, David Ross Camidge
BACKGROUND: Anaplastic lymphoma kinase (ALK) gene rearrangements are oncogenic drivers of non-small-cell lung cancer (NSCLC). Brigatinib (AP26113) is an investigational ALK inhibitor with potent preclinical activity against ALK mutants resistant to crizotinib and other ALK inhibitors. We aimed to assess brigatinib in patients with advanced malignancies, particularly ALK-rearranged NSCLC. METHODS: In this ongoing, single-arm, open-label, phase 1/2 trial, we recruited patients from nine academic hospitals or cancer centres in the USA and Spain...
December 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27809237/discovery-of-bioactive-compounds-by-the-uic-icbg-drug-discovery-program-in-the-18-years-since-1998
#14
REVIEW
Hong-Jie Zhang, Wan-Fei Li, Harry H S Fong, Djaja Doel Soejarto
The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria...
October 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27807299/public-health-benefits-from-pictorial-health-warnings-on-us-cigarette-packs-a-simsmoke-simulation
#15
David T Levy, Darren Mays, Zhe Yuan, David Hammond, James F Thrasher
INTRODUCTION: While many countries have adopted prominent pictorial warning labels (PWLs) for cigarette packs, the USA still requires only small, text-only labels located on one side of the cigarette pack that have little effect on smoking-related outcomes. Tobacco industry litigation blocked implementation of a 2011 Food and Drug Administration's (FDA) rule requiring large PWLs. To inform FDA action on PWLs, this study provides research-based estimates of their public health impacts...
November 2, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27754046/os-14-03-cardiovascular-risk-markers-in-korean-ethnicity-migrants-of-2-3rd-generation-living-in-sakhalin-region
#16
Nina Repina, Tatiana Brodskaya, Vera Nevzorova, Margarita Моkshinа, Evgeniy Аbramov
OBJECTIVE: In conditions of existing immigration flows, the special relevance has researches concerning cardiovascular risk stratification among of different ethnic origin patients living outside the traditional habitats. DESIGN AND METHOD: 180 residents of Sakhalin region with arterial hypertension (AG) I-III degree, I-II stage, 88 Korean ethnicity patients, migrants of 2-3-rd generation, 92 Slavic ethnicity patients (58,2 ± 0,93 years old) were examined. The common risk factors and left ventricle (LV) structural-functional characteristics (Echocardiograph Aсuson X-300 HP, USA) were analyzed...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27702705/robotic-assisted-reconstruction-of-the-cervix-and-vagina-by-small-intestinal-submucosa-graft-and-fusion-of-the-hemiuterus
#17
Ying Zhang, Yisong Chen, Keqin Hua
STUDY OBJECTIVE: To describe our technique of robotic-assisted reconstruction of the cervix and vagina using a small intestinal submucosa (SIS) graft and fusion of the hemiuterus. DESIGN: A step-by-step explanation of the procedure using video. SETTING: Congenital complete vaginal and cervical atresia is rare. Some patients have urinary system abnormality. No standardized surgical treatment guideline was available, and the performance varies for each patient...
October 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27672336/lyme-disease-the-promise-of-big-data-companion-diagnostics-and-precision-medicine
#18
Raphael B Stricker, Lorraine Johnson
Lyme disease caused by the spirochete Borrelia burgdorferi has become a major worldwide epidemic. Recent studies based on Big Data registries show that >300,000 people are diagnosed with Lyme disease each year in the USA, and up to two-thirds of individuals infected with B. burgdorferi will fail conventional 30-year-old antibiotic therapy for Lyme disease. In addition, animal and human evidence suggests that sexual transmission of the Lyme spirochete may occur. Improved companion diagnostic tests for Lyme disease need to be implemented, and novel treatment approaches are urgently needed to combat the epidemic...
2016: Infection and Drug Resistance
https://www.readbyqxmd.com/read/27661788/patient-centered-methadone-treatment-a-randomized-clinical-trial
#19
Robert P Schwartz, Sharon M Kelly, Shannon G Mitchell, Jan Gryczynski, Kevin E O'Grady, Devang Gandhi, Yngvild Olsen, Jerome H Jaffe
BACKGROUND AND AIMS: Methadone patients who discontinue treatment are at high risk of relapse, yet a substantial proportion discontinue treatment within the first year. We investigated whether a patient-centered approach to methadone treatment improved participant outcomes at 12 months following admission, compared with methadone treatment-as-usual. DESIGN: Two-arm open-label randomized trial. SETTING: Two methadone treatment programs (MTPs) in Baltimore, MD, USA...
September 23, 2016: Addiction
https://www.readbyqxmd.com/read/27658870/association-of-age-baseline-kidney-function-and-medication-exposure-with-declines-in-creatinine-clearance-on-pre-exposure-prophylaxis-an-observational-cohort-study
#20
Monica Gandhi, David V Glidden, Kenneth Mayer, Mauro Schechter, Susan Buchbinder, Beatriz Grinsztejn, Sybil Hosek, Martin Casapia, Juan Guanira, Linda-Gail Bekker, Alexander Louie, Howard Horng, Leslie Z Benet, Albert Liu, Robert M Grant
BACKGROUND: As pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine for the prevention of HIV infection is rolled out internationally, strategies to maintain effectiveness and to minimise adverse effects merit consideration. In this study, we aimed to assess reductions in renal function and predictors of renal toxicity in a large open-label study of PrEP. METHODS: As part of the iPrEx open-label extension (OLE) study, men who have sex with men or transgender women aged 18-70 years who were HIV negative and had participated in three previous PrEP trials from Brazil, Ecuador, Peru, South Africa, Thailand, and the USA were enrolled into an open-label PrEP study...
November 2016: Lancet HIV
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