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https://www.readbyqxmd.com/read/28506538/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-coeliac-disease-two-randomised-double-blind-placebo-controlled-phase-1-studies
#1
Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
BACKGROUND: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is intended to engage and render gluten-specific CD4-positive T cells unresponsive to further antigenic stimulation. We assessed the safety and pharmacodynamics of the vaccine in patients with coeliac disease on a gluten-free diet...
May 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28494111/evaluation-of-indicated-non-cosmetic-panniculectomy-at-time-of-gynecologic-surgery
#2
Ryan W Rasmussen, Jay R Patibandla, Michael P Hopkins
OBJECTIVE: To report postoperative outcomes among patients undergoing indicated non-cosmetic panniculectomy at the time of gynecologic surgery. METHODS: Medical charts were retrospectively reviewed for patients who underwent panniculectomy coupled with gynecologic surgery at a university-affiliated hospital in the USA in 1990-2014. The data reviewed included age, body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), surgical procedure, estimated blood loss, pathology, wound complication, diabetes, hypertension, smoking, and readmission rate...
May 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28439701/the-influence-of-different-sets-of-surgical-instrumentation-in-oxford-uka-on-bearing-size-and-component-position
#3
Tilman Walker, Pascal Heinemann, Thomas Bruckner, Marcus R Streit, Stefan Kinkel, Tobias Gotterbarm
INTRODUCTION: The Oxford unicompartmental knee arthroplasty (OUKA) has been proven to be an effective treatment for anteromedial osteoarthritis of the knee joint. New instrumentation has been introduced to improve the reproducibility of implant positioning and to minimize bone loss during tibial resection (Oxford Microplasty; Zimmer Biomet, Warsaw, Indiana, USA). METHODS: To assess the effect of the new instrumentation, we retrospectively evaluated the postoperative radiographs and surgical records of 300 OUKAs in three consecutive cohorts of patients...
April 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28432674/partial-volume-correction-of-brain-pet-studies-using-iterative-deconvolution-in-combination-with-hypr-denoising
#4
Sandeep S V Golla, Mark Lubberink, Bart N M van Berckel, Adriaan A Lammertsma, Ronald Boellaard
BACKGROUND: Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have been proposed as a means to correct for PVE. IDM improves spatial resolution of PET studies without the need for structural information (e.g. MR scans). On the other hand, deconvolution also increases noise, which results in lower signal-to-noise ratios (SNR). The aim of this study was to implement IDM in combination with HighlY constrained back-PRojection (HYPR) denoising to mitigate poor SNR properties of conventional IDM...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28383628/interferon-%C3%AE-induced-protein-10-in-lyme-disease
#5
P Fallahi, G Elia, A Bonatti
Lyme disease is an infectious disease caused by bacteria of the Borrelia type, that affects about 300,000 people a year in the USA and 65,000 people a year in Europe. Borrelia infection, and Lyme disease, following occupational exposure has been frequently reported in USA, Europe and Asia. The manifestations of Lyme disease include erythema migrans (EM), arthritis, neuroborrelliosis (NB), and others. Cytokines and chemokines primarily orchestrate leukocyte recruitment to the areas of Borrelia infection, and they are critical mediators of immune and inflammatory responses, in particular of the induction of interferon (IFN)-γ and IFN-γ dependent chemokines...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28382747/mass-trapping-is-as-effective-as-ground-bait-sprays-for-the-control-of-anastrepha-diptera-tephritidae-fruit-flies-in-mango-orchards
#6
Jorge Villalobos, Salvador Flores, Pablo Liedo, Edi A Malo
BACKGROUND: Anastrepha fruit flies are considered one of the main phytosanitary problems for the fresh fruit industry in the USA, Caribbean islands and Latin America. Since 1994, the Mexican government implemented the National Fruit Fly Program using an area-wide integrated pest management approach. In this paper, we evaluated the effectiveness of mass trapping and compared it with ground GF-120 spraying against Anastrepha obliqua and Anastrepha ludens populations in mango cv Ataulfo orchards...
April 5, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28357716/in-vitro-cytotoxicity-assessment-of-a-west-virginia-chemical-spill-mixture-involving-4-methylcyclohexanemethanol-and-propylene-glycol-phenyl-ether
#7
Alice A Han, Emily B Fabyanic, Julie V Miller, Maren S Prediger, Nicole Prince, Julia A Mouch, Jonathan Boyd
Thousands of gallons of industrial chemicals, crude 4-methylcyclohexanemethanol (MCHM) and propylene glycol phenyl ether (PPh), leaked from industrial tanks into the Elk River in Charleston, West Virginia, USA, on January 9, 2014. A considerable number of people were reported to exhibit symptoms of chemical exposure and an estimated 300,000 residents were advised not to use or drink tap water. At the time of the spill, the existing toxicological data of the chemicals were limited for a full evaluation of the health risks, resulting in concern among those in the impacted regions...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28277076/carbon-dioxide-emission-in-relation-with-irrigation-and-organic-amendments-from-a-sweet-corn-field
#8
Ali Fares, Adam Bensley, Haimanote Bayabil, Ripendra Awal, Samira Fares, Hector Valenzuela, Farhat Abbas
Soil moisture and organic matter level affects soil respiration and microbial activities, which in turn impact greenhouse gas (GHG) emissions. This study was conducted to evaluate the effect of irrigation levels (75% [deficit], 100% [full], and 125% [excess] of reference crop evapotranspiration requirements), and organic amendments (OA) type (chicken manure [CM] and bone meal [BM]) and OA application rates (0,168, 336 and 672 kg total N ha(-1)) on (i) soil physical properties (bulk density, organic matter content and soil moisture content) and (ii) soil carbon dioxide (CO2) emissions from a highly weathered tropical Hawai'ian soil...
March 3, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28270143/residential-distance-to-major-roadways-and-cardiac-structure-in-african-americans-cross-sectional-results-from-the-jackson-heart-study
#9
Anne M Weaver, Gregory A Wellenius, Wen-Chih Wu, DeMarc A Hickson, Masoor Kamalesh, Yi Wang
BACKGROUND: Heart failure (HF) is a significant source of morbidity and mortality among African Americans. Ambient air pollution, including from traffic, is associated with HF, but the mechanisms remain unknown. The objectives of this study were to estimate the cross-sectional associations between residential distance to major roadways with markers of cardiac structure: left ventricular (LV) mass index, LV end-diastolic diameter, LV end-systolic diameter, and LV hypertrophy among African Americans...
March 8, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28260753/molecular-characterization-of-methicillin-resistance-staphylococcus-aureus-mrsa-from-different-tertiary-care-hospitals-in-bangladesh
#10
S Roy, T K Barman, M A Hossain, S K Paul, N Haque, S Ahmed, S A Nasreen, M S Hossain, S R Sarkar, N Kubayashi, N Laskar
Infections caused by Staphylococcus aureus were treated by methicillin, but about 95% of S. aureus has been resistance to methicillin, both in the community and hospitals and are increasing day by day. MRSA produces altered penicillin binding protein, PBP2a, due to the expression of mecA gene. Some strains of both the MRSA and MSSA carry PVL gene. This cross sectional observational study was conducted to detect the molecular-characterization of methicillin resistant Staphylococcus aureus (MRSA) and carried out in the Department of Microbiology, Mymensingh Medical College from July 2014 to December 2015...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28221128/epidemiology-of-nontuberculous-mycobacterial-lung-disease-and-tuberculosis-hawaii-usa
#11
Jennifer Adjemian, Timothy B Frankland, Yihe G Daida, Jennifer R Honda, Kenneth N Olivier, Adrian Zelazny, Stacey Honda, D Rebecca Prevots
Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) and tuberculosis (TB). To better understand NTM infection and TB risk patterns in Hawaii, USA, we evaluated data on a cohort of patients in Hawaii for 2005-2013. Period prevalence of NTMPD was highest among Japanese, Chinese, and Vietnamese patients (>300/100,000 persons) and lowest among Native Hawaiians and Other Pacific Islanders (50/100,000)...
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28221103/disseminated-nontuberculous-mycobacteria-in-hiv-infected-patients-oregon-usa-2007-2012
#12
Cara D Varley, Jennifer H Ku, Emily Henkle, Sean D Schafer, Kevin L Winthrop
We determined disseminated nontuberculous mycobacteria incidence in the HIV-infected population of Oregon, USA, during 2007-2012 by using statewide laboratory surveillance. We identified 37 disseminated nontuberculous mycobacteria cases among 7,349 patients with median annual incidence of 110/100,000 HIV person-years and the highest incidence in those with CD4 counts <50 cells/mm(3) (5,300/100,000 person-years).
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28050669/usa300-a-strain-of-community-associated-methicillin-resistant-staphylococcus-aureus-crossing-belgium-s-borders-outbreak-of-skin-and-soft-tissue-infections-in-a-hospital-in-belgium
#13
K Kaïret, E Ho, D Van Kerkhoven, J Boes, S Van Calenbergh, L Pattyn, P Lemay
OBJECTIVE: to investigate an outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 in a hospital setting, and the effect of infection control measures. DESIGN: outbreak investigation and retrospective chart review. SETTING: local inpatient and outpatient clinic. PATIENTS: all patients with a history of skin and soft tissue infections with culture-confirmed methicillin-resistant Staphylococcus aureus USA 300 infection from September, 2014, through June, 2015...
May 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28045313/parental-knowledge-and-practices-regarding-their-children-s-oral-health-in-kuwait
#14
L Alyahya
AIM: The purpose of this study is to assess the knowledge and practices of parents toward their children's oral health in Kuwait. MATERIALS AND METHODS: Study Design: A cross-sectional study was conducted among 300 parents who visited five dental specialty centers in Kuwait. Data were collected through a self-administered questionnaire. STATISTICS: The statistical analysis was performed using SPSS software (version 21; Inc., Chicago IL, USA)...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28043157/complete-nucleotide-sequence-analysis-of-the-oncogene-meq-from-serotype-1-marek-s-disease-virus-isolates-from-india
#15
P Suresh, J Johnson Rajeswar, K Sukumar, T J Harikrishnan, P Srinivasan
1. A study was undertaken to characterise the oncogene Meq at the molecular level for three serotype 1 Marek's disease virus (MDV) field isolates from vaccinated poultry flocks which had encountered a Marek's disease outbreak in the southern part of India. The isolates were named Ind/TN/11/01, Ind/KA/12/02 and Ind/TN/12/03. The oncogene Meq was amplified by PCR and sequenced. 2. The isolates were shown to have a homology for the Meq gene of 99.1-99.8% with various isolates from China and 98.5-99.2% with isolates from Europe and the USA...
April 2017: British Poultry Science
https://www.readbyqxmd.com/read/28028914/a-systematic-review-of-pregnancy-exposure-registries-examination-of-protocol-specified-pregnancy-outcomes-target-sample-size-and-comparator-selection
#16
Kate Gelperin, Hoda Hammad, Kira Leishear, Steven T Bird, Lockwood Taylor, Christian Hampp, Leyla Sahin
PURPOSE: Our study sought to systematically evaluate protocol-specified study methodology in prospective pregnancy exposure registries including pre-specified pregnancy outcomes, power calculations for sample size, and comparator group selection. METHODS: U.S. pregnancy exposure registries designed to evaluate safety of drugs or biologics were identified from www.clinicaltrials.gov, the FDA's Office of Women's Health website, and the FDA's list of postmarketing studies...
December 27, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28000041/continuous-blood-pressure-monitoring-via-non-invasive-radial-artery-applanation-tonometry-and-invasive-arterial-catheter-demonstrates-good-agreement-in-patients-undergoing-colon-carcinoma-surgery
#17
Jing Sun, Hanjian Chen, Jun Zheng, Bin Mao, Shengmei Zhu, Jingyi Feng
PURPOSE: Radial artery applanation tonometry (RAAT) has been developed and utilized for continuous arterial pressure monitoring. However, evidence is lacking to clinically verify the RAAT technology and identify appropriate patient groups before routine clinical use. This study aims to evaluate the RAAT technology by comparing systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP) values in patients undergoing colon carcinoma surgery. METHODS: Blood Pressure (BP) values obtained via RAAT (TL-300, Tensys Medical Inc...
December 20, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27990844/artificial-heart-pumps-bridging-the-gap-between-science-technology-and-personalized-medicine-by-relational-medicine
#18
Federica Raia, Mario C Deng
In the US population of 300 million, 3 million have heart failure with reduced ejection fraction and 300,000 have advanced heart failure. Long-term mechanical circulatory support will, within the next decade, be recommended to 30,000 patients annually in the USA, 3000 undergo heart transplantation annually. What do these advances mean for persons suffering from advanced heart failure and their loved ones/caregivers? In this perspective article, we discuss - by exemplifying a case report of a 27-year-old man receiving a Total Artificial Heart - a practice concept of modern medicine that fully incorporates the patient's personhood perspective which we have termed Relational Medicine™...
January 2017: Future Cardiology
https://www.readbyqxmd.com/read/27932005/estimating-community-level-costs-of-preterm-birth
#19
E S Hall, J M Greenberg
OBJECTIVES: To develop generalizable methods for estimating the economic impact of preterm birth at the community level on initial hospital expenditures, educational attainment and lost earnings as well as to estimate potential savings associated with reductions in preterm birth. STUDY DESIGN: The retrospective, population-based analysis used vital statistics and population demographics from Hamilton County, Ohio, USA, in 2012. METHODS: We adjusted previously reported, mean initial hospital cost estimates (stratified by each week of gestation) to 2012 dollars using national cost-to-charge ratios...
December 2016: Public Health
https://www.readbyqxmd.com/read/27923385/field-effectiveness-of-microbial-larvicides-on-mosquito-larvae-in-malaria-areas-of-botswana-and-zimbabwe
#20
Mulamuli Mpofu, Piet Becker, Kaka Mudambo, Christiaan de Jager
BACKGROUND: The successful control of malaria vectors requires the control of both the larval and adult stages. The adult control methods through indoor residual spraying (IRS) and use of long-lasting insecticidal nets (LLINs) continue to be widely used with some high measure of success. Larval control methods are also being used by a number of National Malaria Control Programmes (NMCPs) with limited understanding of its contribution. Larval control might be needed in some areas to move from malaria control to elimination...
December 6, 2016: Malaria Journal
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