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USA 300

Nina Repina, Tatiana Brodskaya, Vera Nevzorova, Margarita Моkshinа, Evgeniy Аbramov
OBJECTIVE: In conditions of existing immigration flows, the special relevance has researches concerning cardiovascular risk stratification among of different ethnic origin patients living outside the traditional habitats. DESIGN AND METHOD: 180 residents of Sakhalin region with arterial hypertension (AG) I-III degree, I-II stage, 88 Korean ethnicity patients, migrants of 2-3-rd generation, 92 Slavic ethnicity patients (58,2 ± 0,93 years old) were examined. The common risk factors and left ventricle (LV) structural-functional characteristics (Echocardiograph Aсuson X-300 HP, USA) were analyzed...
September 2016: Journal of Hypertension
Ying Zhang, Yisong Chen, Keqin Hua
STUDY OBJECTIVE: To describe our technique of robotic assisted reconstruction of cervix and vagina by SIS (small intestinal sub-mucosa, SIS) graft and fusion of hemi-uterus. DESIGN: Step-by-step explanation of the procedure using video. SETTING: Congenital complete vaginal and cervical atresia is rare. Some patient has urinary system abnormality. No standardized surgical treatment guideline was available and the performance is varying for each patient...
October 1, 2016: Journal of Minimally Invasive Gynecology
Raphael B Stricker, Lorraine Johnson
Lyme disease caused by the spirochete Borrelia burgdorferi has become a major worldwide epidemic. Recent studies based on Big Data registries show that >300,000 people are diagnosed with Lyme disease each year in the USA, and up to two-thirds of individuals infected with B. burgdorferi will fail conventional 30-year-old antibiotic therapy for Lyme disease. In addition, animal and human evidence suggests that sexual transmission of the Lyme spirochete may occur. Improved companion diagnostic tests for Lyme disease need to be implemented, and novel treatment approaches are urgently needed to combat the epidemic...
2016: Infection and Drug Resistance
Robert P Schwartz, Sharon M Kelly, Shannon Gwin Mitchell, Jan Gryczynski, Kevin E O'Grady, Devang Gandhi, Yngvild Olsen, Jerome H Jaffe
BACKGROUND AND AIMS: Methadone patients who discontinue treatment are at high risk of relapse, yet a substantial proportion discontinue treatment within the first year. We investigated whether a patient-centered approach to methadone treatment improved participant outcomes at 12-months following admission, compared with methadone treatment-as-usual. DESIGN: Two-arm open-label randomized trial. SETTING: Two methadone treatment programs (MTPs) in Baltimore, Maryland, USA...
September 23, 2016: Addiction
Monica Gandhi, David V Glidden, Kenneth Mayer, Mauro Schechter, Susan Buchbinder, Beatriz Grinsztejn, Sybil Hosek, Martin Casapia, Juan Guanira, Linda-Gail Bekker, Alexander Louie, Howard Horng, Leslie Z Benet, Albert Liu, Robert M Grant
BACKGROUND: As pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine for the prevention of HIV infection is rolled out internationally, strategies to maintain effectiveness and to minimise adverse effects merit consideration. In this study, we aimed to assess reductions in renal function and predictors of renal toxicity in a large open-label study of PrEP. METHODS: As part of the iPrEx open-label extension (OLE) study, men who have sex with men or transgender women aged 18-70 years who were HIV negative and had participated in three previous PrEP trials from Brazil, Ecuador, Peru, South Africa, Thailand, and the USA were enrolled into an open-label PrEP study...
August 31, 2016: Lancet HIV
Nina Repina, Tatiana Brodskaya, Vera Nevzorova, Margarita Моkshinа, Evgeniy Аbramov
OBJECTIVE: In conditions of existing immigration flows, the special relevance has researches concerning cardiovascular risk stratification among of different ethnic origin patients living outside the traditional habitats. DESIGN AND METHOD: 180 residents of Sakhalin region with arterial hypertension (AG) I-III degree, I-II stage, 88 Korean ethnicity patients, migrants of 2-3-rd generation, 92 Slavic ethnicity patients (58,2 ± 0,93 years old) were examined. The common risk factors and left ventricle (LV) structural-functional characteristics (Echocardiograph Aсuson X-300 HP, USA) were analyzed...
September 2016: Journal of Hypertension
J Strouse
Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a mutation in the sixth amino acid of the β-globin gene (HBB). It is the most common serious genetic diseases in childhood, affecting approximately 1 in 2500 births and 100 000 individuals in the USA, in addition to 300 000 new cases globally each year. Central nervous system injury is the most debilitating frequent complication of SCD and includes stroke, silent cerebral infarct (SCI), and cognitive impairment. Among children with sickle cell anemia (HbSS), 11% had a stroke by age 18 years before the implementation of transcranial Doppler screening...
2016: Handbook of Clinical Neurology
L N Yelland, B J Gajewski, J Colombo, R A Gibson, M Makrides, S E Carlson
The DHA to Optimize Mother Infant Outcome (DOMInO) and Kansas DHA Outcomes Study (KUDOS) were randomized controlled trials that supplemented mothers with 800 and 600mg DHA/day, respectively, or a placebo during pregnancy. DOMInO was conducted in Australia and KUDOS in the United States. Both trials found an unanticipated and statistically significant reduction in early preterm birth (ePTB; i.e., birth before 34 weeks gestation). However, in each trial, the number of ePTBs were small. We used a novel Bayesian approach to estimate statistically derived low, moderate or high risk for ePTB, and to test for differences between the DHA and placebo groups...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Deepti Rathee, Piyush Arora, Manoj Meena, Rohit Sarin, Pitambar Chakraborty, Anand Jaiswal, Mukesh Goyal
INTRODUCTION: Tuberculosis (TB) is one of the leading causes of death and disease worldwide. Tobacco smoking has been linked as a risk factor for TB. This study was aimed to affirm the strength of association between smoking and pulmonary TB. MATERIALS AND METHODS: Pulmonary TB patients aged between 18 and 65 years were enrolled and followed-up until treatment completion. Two consecutive sputum smears were examined from each patient for the presence of acid-fast bacilli (AFB) using Ziehl-Neelsen technique...
September 2016: Lung India: Official Organ of Indian Chest Society
Victoria Sanchez, Marco D Carpenter, Nicole L Yohn, Julie A Blendy
RATIONALE: Prescription opioid abuse and transition to heroin use are growing problems in the USA. However, the long-term consequences of adolescent prescription opioid abuse on subsequent drug use and affective-like behavior are unknown. OBJECTIVES: This study aims to determine if adolescent exposure to oxycodone alters the rewarding effects of morphine, anxiety-like behavior, and reward-related gene expression later in adulthood. METHODS: Adolescent male C57Bl/6 mice were exposed to oxycodone (3 mg/kg/day) via osmotic minipumps for 28 days...
September 13, 2016: Psychopharmacology
B Lawrenz, F Beligotti, N Engelmann, D Gates, H M Fatemi
STUDY QUESTION: Does hormonal stimulation with corifollitropin alpha (CFA) only, mimicking a step down protocol, result in lower incidence of progesterone elevation on the day of hCGtrigger as compared to sustained stimulation with recombinant FSH (rFSH)? SUMMARY ANSWER: The current findings support the concept that sustained FSH stimulus contributes to premature progesterone elevation in stimulated IVF cycles. WHAT IS KNOWN ALREADY: Serum progesterone rise during the follicular phase of ovarian stimulation for IVF treatment seems to be related to a poorer reproductive outcome...
September 12, 2016: Human Reproduction
Jiaxing Wang, Jinhua Li, Geyong Guo, Qiaojie Wang, Jin Tang, Yaochao Zhao, Hui Qin, Tuerhongjiang Wahafu, Hao Shen, Xuanyong Liu, Xianlong Zhang
Titanium implants are widely used clinically, but postoperative implant infection remains a potential severe complication. The purpose of this study was to investigate the antibacterial activity of nano-silver(Ag)-functionalized Ti surfaces against epidemic Staphylococcus from the perspective of the regulation of biofilm-related genes and based on a bacteria-cell co-culture study. To achieve this goal, two representative epidemic Staphylococcus strains, Staphylococcus epidermidis (S. epidermidis, RP62A) and Staphylococcus aureus (S...
2016: Scientific Reports
Paolo Strati, Mark Lanasa, Timothy G Call, Jose F Leis, Danielle M Brander, Betsy R LaPlant, Adam M Pettinger, Wei Ding, Sameer A Parikh, Curtis A Hanson, Asher A Chanan-Khan, Deborah A Bowen, Michael Conte, Neil E Kay, Tait D Shanafelt
BACKGROUND: Although several consolidation strategies to prolong treatment-free survival (TFS) in chronic lymphocytic leukaemia have been investigated, most have proven either ineffective or toxic. Ofatumumab is a human type I anti-CD20 antibody approved by the US Food and Drug Administration as maintenance treatment of patients with recurrent or progressive chronic lymphocytic leukaemia who are in complete or partial response after at least two lines of treatment; higher efficacy might be observed if used as consolidation strategy than without consolidation in previously untreated patients...
September 2016: Lancet Haematology
Kevin N Sheth, Jordan J Elm, Bradley J Molyneaux, Holly Hinson, Lauren A Beslow, Gordon K Sze, Ann-Christin Ostwaldt, Gregory J Del Zoppo, J Marc Simard, Sven Jacobson, W Taylor Kimberly
BACKGROUND: Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival. We assessed whether intravenous glyburide (RP-1127; glibenclamide) would safely reduce brain swelling, decrease the need for decompressive craniectomy, and improve clinical outcomes in patients presenting with a large hemispheric infarction. METHODS: For this double-blind, randomised, placebo-controlled phase 2 trial, we enrolled patients (aged 18-80 years) with a clinical diagnosis of large anterior circulation hemispheric infarction for less than 10 h and baseline diffusion-weighted MRI image lesion volume of 82-300 cm(3) on MRI at 18 hospitals in the USA...
October 2016: Lancet Neurology
Lara A Carlson, Michael A Lawrence, Kaylee LeCavalier, Alexander J Koch
The purpose of this study was to examine the impact of anaerobic training on salivary lymphocytes (s-LYMPH), and further determine whether these responses differ between cool vs. thermoneutral environments. Nine lightly clothed (∼0.3 clo) volunteers (7/2 women/men: age 21 ± 1 y; height 168.7 ± 7.3 cm; weight 66.4 ± 8.4 kg; body fat 20.6 ± 7.6%) completed speed, agility, and quickness (SAQ) sessions in both warm (18.9°C, Biddeford, Maine, USA) and cool (10.4°C, Thorsmörk, Iceland) temperatures. SAQ sessions consisted of three trials of 20 m sprints, 40 m sprints, t-tests, and box drills, and two 300-yd shuttle runs in both conditions...
August 16, 2016: Journal of Strength and Conditioning Research
Meenakshi Wadhwani, Sanjay K Mishra, Dewang Angmo, Thirumurthy Velpandian, Ramanjit Sihota, Ankita Kotnala, Shibal Bhartiya, Tanuj Dada
PURPOSE: Comparative evaluation of pharmaceutical characteristics of three marketed generic vs branded travoprost formulations. MATERIALS AND METHODS: Three generic travoprost formulations and one branded (Travatan without benzalkonium chloride) formulation (10 vials each), obtained from authorized agents from the respective companies and having the same batch number, were used. These formulations were coded and labels were removed. At a standardized room temperature of 25°C, the drop size, pH, relative viscosity, and total drops per vial were determined for Travatan (Alcon, Fort Worth, TX, USA) and all the generic formulations...
May 2016: Journal of Current Glaucoma Practice
Rita Banzi, Paolo Camaioni, Mauro Tettamanti, Vittorio Bertele', Ugo Lucca
BACKGROUND: The age gap between participants in trials and patients who could benefit from the drugs studied has been widely documented across different clinical areas. Patients with dementia included in clinical research are systematically younger than those in the general population. We examined the age gap between participants in recent clinical trials testing interventions for Alzheimer's disease and epidemiological data. METHODS: We systematically searched literature databases (MedLine, EMBASE, the Cochrane Library) and ClinicalTrials...
2016: Alzheimer's Research & Therapy
Nenad Petrovic
Since early seventies of the twentieth century, through seminal work of Judah Folkman, angiogenesis, the process of new blood vessel sprouting from the existing vasculature, was recognized as a necessary part of wound healing, development of placenta, tissue growth and regeneration as well as cancer progression. This process is induced by low tissue oxygenation and it is a crucial prerequisite for rapid tissue growth, providing proper oxygen supply and removal of toxic metabolites. Suppression of angiogenesis as a way of slowing down tumor progression continues to be one of the most important areas of cancer research...
April 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Emily Ca Stone, Caicun Zhou
China is home to a third of the world's smokers and, correspondingly, to a third of the world's cases of lung cancer. Beginning in the mid-1990s, a generation or so later than in many western countries, the Chinese government commenced measures to control tobacco, limiting advertising, banning smoking in many public venues and increasing taxation. At the time of this review, there are signs that these policies are having some effect, but hundreds of millions of Chinese continue to smoke and rates of diagnosis of lung cancer continue to rise...
August 3, 2016: Journal of Thoracic Oncology
Joyce L Ross
Hypercholesterolemia is a major concern in the USA, with studies identifying children as young as 2years old with early-stage atherosclerosis. Genetics play a major role in the dyslipidemia of children, but other factors, such as diet and lack of physical activity, confound the problem. Familial hypercholesterolemia (FH) is a genetic condition that causes lifelong elevations in low-density lipoprotein cholesterol (LDL-C). The heterozygous form of the disease affects around 1 in 200 people, and the homozygous form of the disease affects around 1 in 160,000-300,000 people...
August 2, 2016: Journal of Pediatric Nursing
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