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https://www.readbyqxmd.com/read/28511095/independent-validation-of-dna-based-approaches-for-age-prediction-in-blood
#1
Sohee Cho, Sang-Eun Jung, Sae Rom Hong, Eun Hee Lee, Ji Hyun Lee, Soong Deok Lee, Hwan Young Lee
Numerous molecular biomarkers have been proposed as predictors of chronological age. Among them, T-cell specific DNA rearrangement and DNA methylation markers have been introduced as forensic age predictors in blood because of their high prediction accuracy. These markers appear highly promising, but for better application to forensic casework sample analysis the proposed markers and genotyping methods must be tested further. In the current study, signal-joint T-cell receptor excision circles (sjTRECs) and DNA methylation markers located in the ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 genes were reanalyzed in 100 Korean blood samples to test their associations with chronological age, using the same analysis platform used in previous reports...
April 28, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28500091/forensic-age-estimation-using-the-medial-clavicular-epiphysis-a-study-review
#2
Mary B Buckley, Kevin R Clark
PURPOSE: To discuss current literature evaluating the medial clavicular epiphysis to assess an individual's age using various imaging modalities. METHODS: Four scholarly research databases were searched to find studies that examined living subjects. Several articles were included that used cadavers, and a textbook was used to detail the anatomy of the clavicle. Thirty-nine articles were analyzed. RESULTS: The literature indicated that several imaging modalities, including conventional radiography, computed tomography, magnetic resonance, and sonography, are being used to evaluate the medial clavicular epiphysis to estimate an individual's age in the forensic context...
May 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28486142/the-age-related-expression-decline-of-ercc1-and-xpf-for-forensic-age-estimation-a-preliminary-study
#3
Xiao-Dong Deng, Qin Gao, Wei Zhang, Bo Zhang, Ying Ma, Li-Xia Zhang, Cheer Muer, Ying Xie, Yun Liu
The age-related capacity decline of DNA damage repair in human peripheral blood has been demonstrated. Excision repair cross-complementation group1 (ERCC1) and Xeroderma pigmentosum complementation group F (XPF) were rate-limiting enzyme in nucleotide excision repair (NER) which was known as the most important DNA damage repair system. Consequently, we hypothesized that the expression and/or activity of ERCC1 and XPF may be associated with age. However, little was known about the quantitative relationship of ERCC1 and XPF expression levels with age...
May 3, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28482246/validation-of-third-molar-maturity-index-i3m-for-discrimination-of-juvenile-adult-status-in-south-indian-population
#4
Sudheer B Balla, Ivan Galic, Karunakar P, Stefano Vanin, Stefano De Luca, Roberto Cameriere
Deliberate falsification of age was considered to be one of the main reasons for forensic age estimation of the living individuals. This posed to be a challenging task during criminal and legal proceedings, and ultimate care must be taken not to classify juveniles as adults. Third molars are the only developing teeth during late adolescence and early adulthood. Our study was designed to analyze the usefulness of the third molar maturity index (I3M) specific cut-off value (I3M < 0.08) to discriminate adults (≥18 years) and juveniles (<18 years) in South Indian children...
May 3, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28439695/usefulness-of-telomere-length-in-dna-from-human-teeth-for-age-estimation
#5
Ana Belén Márquez-Ruiz, Lucas González-Herrera, Aurora Valenzuela
Age estimation is widely used to identify individuals in forensic medicine. However, the accuracy of the most commonly used procedures is markedly reduced in adulthood, and these methods cannot be applied in practice when morphological information is limited. Molecular methods for age estimation have been extensively developed in the last few years. The fact that telomeres shorten at each round of cell division has led to the hypothesis that telomere length can be used as a tool to predict age. The present study thus aimed to assess the correlation between telomere length measured in dental DNA and age, and the effect of sex and tooth type on telomere length; a further aim was to propose a statistical regression model to estimate the biological age based on telomere length...
April 24, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28407514/age-estimation-from-structural-changes-of-teeth-and-buccal-alveolar-bone-level
#6
K K Koh, J S Tan, P Nambiar, Norliza Ibrahim, Sunil Mutalik, Muhammad Khan Asif
Forensic odontology plays a vital role in the identification and age estimation of unknown deceased individuals. The purpose of this study is to estimate the chronological age from Cone-Beam Computed Tomography (CBCT) images by measuring the buccal alveolar bone level (ABL) to the cemento-enamel junction and to investigate the possibility of employing the age-related structural changes of teeth as studied by Gustafson. In addition, this study will determine the forensic reliability of employing CBCT images as a technique for dental age estimation...
April 1, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28254385/dna-methylation-based-forensic-age-prediction-using-artificial-neural-networks-and-next-generation-sequencing
#7
Athina Vidaki, David Ballard, Anastasia Aliferi, Thomas H Miller, Leon P Barron, Denise Syndercombe Court
The ability to estimate the age of the donor from recovered biological material at a crime scene can be of substantial value in forensic investigations. Aging can be complex and is associated with various molecular modifications in cells that accumulate over a person's lifetime including epigenetic patterns. The aim of this study was to use age-specific DNA methylation patterns to generate an accurate model for the prediction of chronological age using data from whole blood. In total, 45 age-associated CpG sites were selected based on their reported age coefficients in a previous extensive study and investigated using publicly available methylation data obtained from 1156 whole blood samples (aged 2-90 years) analysed with Illumina's genome-wide methylation platforms (27K/450K)...
May 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28123278/cementum-as-an-age-determinant-a-forensic-view
#8
Godishala Swamy Sugunakar Raju, Muddana Keerthi, Surapaneni Rateesh Kumar Nandan, Thokala Madhusudan Rao, Pavan G Kulkarni, Dorankula Shyam Prasad Reddy
CONTEXT: Forensic age estimation (FAE) defines an expertise in forensic medicine, which aims to define in the most accurate way to determine the unknown chronological age of the person involved in judicial or legal proceedings. Dental cementum is a vital tissue which demonstrates continuous apposition throughout the life of the tooth. This appositional changes of cementum helps in approximation of age inforensic investigations. AIMS: To correlate age by measuring the overlap or coronal migration of thecementum at thecementoenamel junction (CEJ) and the thickness of the cementum at the apical third of the root...
September 2016: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28032243/the-role-of-forensic-medicine-and-forensic-dentistry-in-estimating-the-chronological-age-of-living-individuals-in-hamburg-germany
#9
Hussam Mansour, Andreas Fuhrmann, Ioana Paradowski, Eilin Jopp van Well, Klaus Püschel
Age estimation represents one of the primary responsibilities of forensic medicine and forensic dentistry. It is an integral procedure aiming to estimate the chronological age of an individual, whose age is either unknown or doubtful, by means of assessing the stage of dental, skeletal, and physical development. The present publication reviews the methods and procedures used in estimating the age of young living individuals as well as the experiences of the Institute of Legal Medicine in Hamburg-Eppendorf, Germany, during the last 25 years...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27981359/evaluation-of-the-ossification-of-the-medial-clavicle-according-to-the-kellinghaus-substage-system-in-identifying-the-18-year-old-age-limit-in-the-estimation-of-forensic-age-is-it-necessary
#10
Murat Serdar Gurses, Nursel Turkmen Inanir, Esra Soylu, Gokhan Gokalp, Elif Kir, Recep Fedakar
The evaluation of the ossification of the medial clavicular epiphysis being part of an assigned expert approach according to standard plays an important role within civil and criminal proceedings in assessing whether a person has reached her/his 19th or 22nd year of age. Evaluation of the medial clavicular epiphysis with thin-section CT is one of the methods recommended by the Study Group on Forensic Age Diagnostics of the German Association of Forensic Medicine. In this retrospective study, we evaluated the thin-section CT (section thickness of 0...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27930820/a-bayesian-approach-to-age-at-death-estimation-from-osteoarthritis-of-the-shoulder-in-modern-north-americans
#11
Ashley L Brennaman, Kim R Love, Jonathan D Bethard, James T Pokines
Osteoarthritis (OA) is a marker of degeneration within the skeleton, frequently associated with age. This study quantifies the correlation between OA and age-at-death and investigates the utility of shoulder OA as a forensic age indicator using a modern North American sample of 206 individuals. Lipping, surface porosity, osteophyte formation, eburnation, and percentage of joint surface affected were recorded on an ordinal scale and summed to create composite scores that were assigned a specific phase. Spearman's correlation indicated a positive relationship between each composite score and age (right shoulder = 0...
May 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27924404/magnetic-resonance-imaging-of-the-distal-radial-epiphysis-a-new-criterion-of-maturity-for-determining-whether-the-age-of-18-has-been-completed
#12
M Timme, C Ottow, R Schulz, H Pfeiffer, W Heindel, V Vieth, A Schmeling, S Schmidt
To improve the accuracy of forensic age estimation where there is no legal basis for carrying out x-ray examinations, it would be useful to establish non-x-ray imaging techniques. The objective of this study was to provide reference data for the magnetic resonance imaging-based evaluation of the ossification stage of the distal radius. Furthermore, we tested a new criterion of the maturity of the distal radial epiphysis for determining whether an individual has completed the age of 18. We investigated 668 MRI scans of the distal radial epiphysis from 333 female and 335 male subjects ranging in age from 12 to 24...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27909868/dental-age-estimation-in-the-living-after-completion-of-third-molar-mineralization-new-data-for-gustafson-s-criteria
#13
M Timme, W H Timme, A Olze, C Ottow, S Ribbecke, H Pfeiffer, R Dettmeyer, A Schmeling
There is a need for dental age estimation methods after completion of the third molar mineralization. Degenerative dental characteristics appear to be suitable for forensic age diagnostics beyond the 18th year of life. In 2012, Olze et al. investigated the criteria studied by Gustafson using orthopantomograms. The objective of this study was to prove the applicability and reliability of this method with a large cohort and a wide age range, including older individuals. For this purpose, 2346 orthopantomograms of 1167 female and 1179 male Germans aged 15 to 70 years were reviewed...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27908672/forensic-age-estimation-in-anti-piracy-trials-in-seychelles-experiences-and-challenges-faced
#14
S A Gunawardena, U A Liyanage, J B Weeratna, N D N A Mendis, H J M Perera, R W Jayasekara, R Fernando
Forensic age estimation (FAE) was conducted using a multifactorial method on thirteen Somali detainees claiming juvenile status during the anti-piracy trials of the Seychelles Supreme Court in 2014/2015. A multidisciplinary team, comprising of four of the authors covering specialties in forensic medicine, forensic odontology and radiology, conducted the FAE using a five-stage protocol. Each detainee was interviewed with an interpreter and examined for disorders affecting dental/skeletal development and for assessment of genital development through Tanner staging...
November 14, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27885641/apophyseal-ossification-of-the-iliac-crest-in-forensic-age-estimation-computed-tomography-standards-for-modern-australian-subadults
#15
Nicolene Lottering, Clair L Alston-Knox, Donna M MacGregor, Maree T Izatt, Caroline A Grant, Clayton J Adam, Laura S Gregory
This study contrasts the ontogeny of the iliac crest apophysis using conventional radiography and multislice computed tomography (MSCT), providing probabilistic information for age estimation of modern Australian subadults. Retrospective abdominopelvic MSCT data acquired from 524 Australian individuals aged 7-25 and surveillance radiographs of adolescent idiopathic scoliosis patients included in the Paediatric Spine Research Group Progression Study (n = 531) were assessed. Ossification scoring of pseudo-radiographs and three-dimensional (3D) volume-rendered reconstructions using Risser (1958) quantitative descriptors indicate discrepancies in age estimates, stage allocation, and conflicting morphological progression...
November 25, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27885431/forensic-age-assessment-of-asylum-seekers-in-finland
#16
Mari Metsäniitty, Olli Varkkola, Janna Waltimo-Sirén, Helena Ranta
In Finland, forensic age assessment is strictly regulated by legislation. According to the Aliens Act (301/2004) and the amendment of the Act (549/2010), the police authorities, the frontier guard authorities, and the immigration authorities have the right to refer asylum seekers to the University of Helsinki, Department of Forensic Medicine, for age assessment. These assessments are especially performed to solve if the person is of major age, the cutoff being 18 completed years. The forensic age assessment is largely based on dental development, since the special permit of the Radiation and Nuclear Safety Authority (STUK) to the Department of Forensic Medicine of the University of Helsinki, allowing the use of ionizing radiation for non-medical purposes, includes dental and hand X-rays...
January 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27825336/dental-age-assessment-in-6-to-14-year-old-german-children-comparison-of-cameriere-and-demirjian-methods
#17
Thomas Gerhard Wolf, Benjamín Briseño-Marroquín, Angelika Callaway, Michael Patyna, Victor Thomas Müller, Ines Willershausen, Vicky Ehlers, Brita Willershausen
BACKGROUND: The aim of the study was to compare two frequently used dental age estimation methods for accuracy. METHODS: A total of 479 panoramic radiographs in age groups 6-14 years from a German population were evaluated. The dental age of 268 boys and 211 girls was assessed by means of the method of Demirjian (1973) and Cameriere (2006) and compared with their actual chronological age. RESULTS: Demirjan's method showed an overestimation of dental age compared to chronological age in all age groups for boys (mean difference -0...
November 8, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27770721/forensic-age-estimation-of-living-persons-from-the-knee-comparison-of-mri-with-radiographs
#18
Fei Fan, Kui Zhang, Zhao Peng, Jing-Hui Cui, Na Hu, Zhen-Hua Deng
To perform a study to clarify how strong the chronological age relates to ossification of the knee in Chinese on X-rays and the MRI when a similar four-stage grading system was used. 322 individuals with conventional radiographs and MRI were collected from routine medical investigations and evaluated retrospectively. Bland Altman plots were performed to reveal the agreement of grading of MRI and radiograph. Regression analysis was conducted to establish a mathematical model for age estimation. The ossification process of the knee occurs earlier in females than in males for about 1-2 years...
November 2016: Forensic Science International
https://www.readbyqxmd.com/read/27658782/systematic-procedure-for-identifying-the-five-main-ossification-stages-of-the-medial-clavicular-epiphysis-using-computed-tomography-a-practical-proposal-for-forensic-age-diagnostics
#19
REVIEW
Daniel Wittschieber, Ronald Schulz, Heidi Pfeiffer, Andreas Schmeling, Sven Schmidt
In forensic age estimations of living individuals, computed tomography of the clavicle is widely used for determining the age of majority. To this end, the degree of ossification of the medial clavicular epiphysis can be determined by means of two classification systems complementing each other: a 5-stage system and an additional 6-stage system that further sub-classifies the stages 2 and 3. In recent years, practical experience and new data revealed that difficulties and even wrong stage determinations may occur especially when following the short descriptions of the fundamental 5-stage system only...
January 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27650301/forensic-age-estimation-based-on-magnetic-resonance-imaging-of-third-molars-converting-2d-staging-into-3d-staging
#20
COMPARATIVE STUDY
Jannick De Tobel, Elke Hillewig, Koenraad Verstraete
BACKGROUND: Established methods to stage development of third molars for forensic age estimation are based on the evaluation of radiographs, which show a 2D projection. It has not been investigated whether these methods require any adjustments in order to apply them to stage third molars on magnetic resonance imaging (MRI), which shows 3D information. AIM: To prospectively study root stage assessment of third molars in age estimation using 3 Tesla MRI and to compare this with panoramic radiographs, in order to provide considerations for converting 2D staging into 3D staging and to determine the decisive root...
March 2017: Annals of Human Biology
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