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https://www.readbyqxmd.com/read/29804276/applicability-of-t1-weighted-mri-in-the-assessment-of-forensic-age-based-on-the-epiphyseal-closure-of-the-humeral-head
#1
Oguzhan Ekizoglu, Ercan Inci, Suna Ors, Ismail Eralp Kacmaz, Can Doruk Basa, Ismail Ozgur Can, Elena F Kranioti
This work investigates the value of magnetic resonance imaging analysis of proximal epiphyseal fusion in research examining the growth and development of the humerus and its potential utility in establishing forensic age estimation. In this study, 428 proximal humeral epiphyses (patient age, 12-30 years) were evaluated with T1-weighted turbo spin echo (T1 TSE) sequences in coronal oblique orientation on shoulder MRI images. A scoring system was created following a combination of the Schmeling and Kellinghaus methods...
May 26, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29744586/a-systematic-review-and-meta-analysis-of-the-fully-formed-wisdom-tooth-as-a-radiological-marker-of-adulthood
#2
Mattias Haglund, Håkan Mörnstad
Assessment of third molar development on dental radiograms is one of the most commonly used methods of forensic age estimation. Despite widespread use and numerous studies, there is a paucity of aggregated data on how well a fully mature third molar identifies adulthood (> 18 years), the most important threshold in a medicolegal context. Therefore, a systematic review and meta-analysis was conducted. A total of 1229 studies were screened, and 82 studies were assessed for inclusion. Twenty-four studies, with a pooled cohort of 19,690 individuals, presented true positive (TP), true negative (TN), false positive (FP), and false negative (FN) outcomes, enabling meta-analysis...
May 10, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29713801/forensic-age-estimation-using-computed-tomography-of-the-medial-clavicular-epiphysis-a-systematic-review
#3
REVIEW
Coralie Hermetet, Pauline Saint-Martin, Arsène Gambier, Léo Ribier, Bénédicte Sautenet, Camille Rérolle
Medicolegal physicians are increasingly called upon to aid in determining the administrative age group affiliation of refugees with questionable unaccompanied minor claims. According to guidelines for forensic age assessment, age differentiation along the 18-year-old cut-off relies on clavicular ossification. The thin-slice computed tomography scan (TSCTs) of the medial clavicular epiphysis (MCE) is one of the methods contributing to this assessment, though it is not yet universally accepted. The aim of this systematic review was to identify scientific papers where age was assessed using TSCTs of the MCE and to observe whether this examination was reproducible and reliable in estimating a person's age relative to the 18-year-old threshold...
April 30, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29536244/forensic-age-assessment-by-3-0t-mri-of-the-knee-proposal-of-a-new-mri-classification-of-ossification-stages
#4
Volker Vieth, Ronald Schulz, Walter Heindel, Heidi Pfeiffer, Boris Buerke, Andreas Schmeling, Christian Ottow
PURPOSE: To explore the possibility of determining majority via a morphology-based examination of the epiphyseal-diaphyseal fusion by 3.0 T magnetic resonance imaging (MRI), a prospective cross-sectional study developing and applying a new stage classification was conducted. MATERIALS AND METHODS: 344 male and 350 female volunteers of German nationality between the ages of 12-24 years were scanned between May 2013 and June 2015. A 3.0 T MRI scanner was used, acquiring a T1-weighted (T1-w) turbo spin-echo sequence (TSE) and a T2-weighted (T2-w) TSE sequence with fat suppression by spectral pre-saturation with inversion recovery (SPIR)...
March 13, 2018: European Radiology
https://www.readbyqxmd.com/read/29477092/evaluation-of-three-statistical-prediction-models-for-forensic-age-prediction-based-on-dna-methylation
#5
Inge Smeers, Ronny Decorte, Wim Van de Voorde, Bram Bekaert
DNA methylation is a promising biomarker for forensic age prediction. A challenge that has emerged in recent studies is the fact that prediction errors become larger with increasing age due to interindividual differences in epigenetic ageing rates. This phenomenon of non-constant variance or heteroscedasticity violates an assumption of the often used method of ordinary least squares (OLS) regression. The aim of this study was to evaluate alternative statistical methods that do take heteroscedasticity into account in order to provide more accurate, age-dependent prediction intervals...
May 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29391552/reducing-acquisition-time-for-mri-based-forensic-age-estimation
#6
Bernhard Neumayer, Matthias Schloegl, Christian Payer, Thomas Widek, Sebastian Tschauner, Thomas Ehammer, Rudolf Stollberger, Martin Urschler
Radiology-based estimation of a living person's unknown age has recently attracted increasing attention due to large numbers of undocumented immigrants entering Europe. To avoid the application of X-ray-based imaging techniques, magnetic resonance imaging (MRI) has been suggested as an alternative imaging modality. Unfortunately, MRI requires prolonged acquisition times, which potentially represents an additional stressor for young refugees. To eliminate this shortcoming, we investigated the degree of reduction in acquisition time that still led to reliable age estimates...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29384743/forensic-age-estimation-based-on-development-of-third-molars-a-staging-technique-for-magnetic-resonance-imaging
#7
J De Tobel, I Phlypo, S Fieuws, C Politis, K L Verstraete, P W Thevissen
BACKGROUND: The development of third molars can be evaluated with medical imaging to estimate age in subadults. The appearance of third molars on magnetic resonance imaging (MRI) differs greatly from that on radiographs. Therefore a specific staging technique is necessary to classify third molar development on MRI and to apply it for age estimation. AIM: To develop a specific staging technique to register third molar development on MRI and to evaluate its performance for age estimation in subadults...
December 1, 2017: Journal of Forensic Odonto-stomatology
https://www.readbyqxmd.com/read/29384738/are-cervical-vertebrae-suitable-for-age-estimation
#8
B Gelbrich, M Fischer, A Stellzig-Eisenhauer, G Gelbrich
BACKGROUND: The ability of cervical vertebrae (CV) staging to contribute in forensic age estimation is being discussed controversially. The large variability of CV geometries in the end stage of development might be the reason for not reaching a performance competitive to hand or third molar methods. Here we study the geometry of adult CV and demonstrate that the description of their "typical" appearance is often not met. MATERIALS AND METHODS: Lateral cephalograms from clinical routine of 320 subjects aged 20 years or above (median 24 years, 52% female) were evaluated...
December 1, 2017: Journal of Forensic Odonto-stomatology
https://www.readbyqxmd.com/read/29353220/quantification-of-spheno-occipital-synchondrosis-fusion-in-a-contemporary-malaysian-population
#9
Salina Hisham, Ambika Flavel, Nurliza Abdullah, Mohamad Helmee Mohamad Noor, Daniel Franklin
Timing of fusion of the spheno-occipital synchondrosis (SOS) is correlated with age. Previous research, however, has demonstrated variation in the timing of closure among different global populations. The present study aims to quantify the timing of SOS fusion in Malaysian individuals as visualised in multi-detector computed tomography (CT) scans and to thereafter formulate age estimation models based on fusion status. Anonymised cranial CT scans of 336 males and 164 females, aged 5-25 years, were acquired from the National Institute of Forensic Medicine, Hospital Kuala Lumpur and Department of Diagnostic Imaging, Hospital Sultanah Aminah...
March 2018: Forensic Science International
https://www.readbyqxmd.com/read/29248958/reliability-of-the-greulich-and-pyle-method-for-chronological-age-estimation-and-age-majority-prediction-in-a-spanish-sample
#10
M Alcina, A Lucea, M Salicrú, D Turbón
Estimating the forensic age of living individuals is ever more important in forensic practice, due to the ongoing increase of migratory flows, amongst other causes. Using the Greulich and Pyle method on a sample of 1150 individuals of the Spanish population (n = 560, 0-18 years for girls, and n = 590, 0-19 years for boys), the mean difference between the bone and chronological ages was obtained: 0.01 years (- 0.81, + 0.92) for girls and 0.33 years (- 1.15, + 0.34) for boys. For a same class of age and sex, the inherent variability was also evaluated: [Formula: see text] (0...
December 16, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29195663/forensic-age-at-death-estimation-from-the-sternum-in-a-black-south-african-population
#11
Nicholas Bacci, Elsie Koketso Nchabeleng, Brendon Kurt Billings
Age-at-death estimation is a crucial component of any forensic anthropological analysis. Despite a variety of research in this field, uncertainties still exist when estimating adult age. The sternum is an under-considered element in terms of adult age estimation. Previous research on an Indian population suggested that this may be a usable region of the skeleton, although results were ambivalent. This study observed the fusion phases of 461 sterna from a black South African population in an attempt to match true age of an individual with the different phases of synostosis of the manubrio-sternal and the sterno-xiphoidal junctions...
January 2018: Forensic Science International
https://www.readbyqxmd.com/read/29162298/on-the-bayesian-approach-to-forensic-age-estimation-of-living-individuals
#12
Emanuele Sironi, Joëlle Vuille, Niels Morling, Franco Taroni
Forensic age estimation, a branch of forensic science, has received renewed attention lately mainly due to societal migration phenomena. And yet, the interpretation of age-related evidence is still largely neglected as a field, the literature being usually limited to technical discussions strictly pertaining to the statistical methodologies to be used in estimation process. This short communication aims to highlight the fundamental role of evidence evaluation and interpretation in forensic age estimation. We illustrate why the Bayesian approach represents the best choice in such a perspective...
December 2017: Forensic Science International
https://www.readbyqxmd.com/read/29129975/forensic-age-estimation-of-chinese-malaysian-adults-by-evaluating-occlusal-tooth-wear-using-modified-kim-s-index
#13
Chai Kit Lu, Margaret Chia Soo Yee, Spoorthi Banavar Ravi, Rohit Pandurangappa
Background and Objective: Evaluation of dental attrition is an easy and relatively accurate approach to estimating the age of an adult either ante- or postmortem for some specific population. Dental attrition represents a progressive physiological age change that can be measured using variety of indices to aid as an adjunct in forensic age estimation. Some of the previously proposed indices have their own practical limitations. This paper focuses on using modified Kim's criteria to score dental attrition to estimate the age of Chinese Malaysian adults and validate it...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28889331/magnetic-resonance-imaging-based-evaluation-of-ossification-of-the-medial-clavicular-epiphysis-in-forensic-age-assessment
#14
S Schmidt, C Ottow, H Pfeiffer, W Heindel, V Vieth, A Schmeling, R Schulz
Evaluation of the degree of ossification of the medial clavicular epiphysis plays a crucial role in determining with an adequate degree of probability whether legally relevant age boundaries after the age of 17 have been crossed. In view of the need to avoid unnecessary radiation exposure, establishing non-X-ray methods for investigating the clavicle has long been a key objective in forensic age assessment research. Based on magnetic resonance imaging examinations in a large sample of healthy subjects, the current study for the first time presents statistical measures which allow inferences to be drawn for forensic age assessment in both sexes...
September 9, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28874809/forensic-age-prediction-for-saliva-samples-using-methylation-sensitive-high-resolution-melting-exploratory-application-for-cigarette-butts
#15
Yuya Hamano, Sho Manabe, Chie Morimoto, Shuntaro Fujimoto, Keiji Tamaki
There is high demand for forensic age prediction in actual crime investigations. In this study, a novel age prediction model for saliva samples using methylation-sensitive high resolution melting (MS-HRM) was developed. The methylation profiles of ELOVL2 and EDARADD showed high correlations with age and were used to predict age with support vector regression. ELOVL2 was first reported as an age predictive marker for saliva samples. The prediction model showed high accuracy with a mean absolute deviation (MAD) from chronological age of 5...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28725932/dna-methylation-in-elovl2-and-c1orf132-correctly-predicted-chronological-age-of-individuals-from-three-disease-groups
#16
M Spólnicka, E Pośpiech, B Pepłońska, R Zbieć-Piekarska, Ż Makowska, A Pięta, J Karłowska-Pik, B Ziemkiewicz, M Wężyk, P Gasperowicz, T Bednarczuk, M Barcikowska, C Żekanowski, R Płoski, Wojciech Branicki
Improving accuracy of the available predictive DNA methods is important for their wider use in routine forensic work. Information on age in the process of identification of an unknown individual may provide important hints that can speed up the process of investigation. DNA methylation markers have been demonstrated to provide accurate age estimation in forensics, but there is growing evidence that DNA methylation can be modified by various factors including diseases. We analyzed DNA methylation profile in five markers from five different genes (ELOVL2, C1orf132, KLF14, FHL2, and TRIM59) used for forensic age prediction in three groups of individuals with diagnosed medical conditions...
January 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28707524/applicability-of-cameriere-s-and-drusini-%C3%AF-s-age-estimation-methods-to-a-sample-of-turkish-adults
#17
Boyacioglu Dogru Hatice, Avcu Nihal, Akkaya Nursel, Yilanci Humeyra Ozge, Dincer Goksuluk
OBJECTIVES: The aim of this study was to investigate the applicability of Drusini's and Cameriere's methods to a sample of Turkish people. METHODS: Panoramic images of 200 individuals were allocated into two groups as study and test groups and examined by two observers. Tooth coronal indexes (TCI), which is the ratio between coronal pulp cavity height and crown height, were calculated in the mandibular first and second premolars and molars. Pulp/tooth area ratios (ARs) were calculated in the maxillary and mandibular canine teeth...
October 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28706489/difference-in-striae-periodicity-of-heilongjiang-and-singaporean-chinese-teeth
#18
Sharon H X Tan, Yu Fan Sim, Chin-Ying S Hsu
Striae periodicity refers to the number of cross-striations between successive lines of Retzius in tooth enamel. A regular time dependency of striae periodicity, known as the circaseptan interval, has been proposed. Previous studies on striae periodicity have been carried out on both modern and early humans given its potential applications in forensic age estimations and anthropology. Nevertheless, research comparing striae periodicities across gender groups and populations in different geographical locations, particularly in Asia, is lacking...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28691915/forensic-individual-age-estimation-with-dna-from-initial-approaches-to-methylation-tests
#19
REVIEW
A Freire-Aradas, C Phillips, M V Lareu
Individual age estimation is a key factor in forensic science analysis that can provide very useful information applicable to criminal, legal, and anthropological investigations. Forensic age inference was initially based on morphological inspection or radiography and only later began to adopt molecular approaches. However, a lack of accuracy or technical problems hampered the introduction of these DNA-based methodologies in casework analysis. A turning point occurred when the epigenetic signature of DNA methylation was observed to gradually change during an individual´s lifespan...
July 2017: Forensic Science Review
https://www.readbyqxmd.com/read/28677057/forensic-age-estimation-by-magnetic-resonance-imaging-of-the-knee-the-definite-relevance-in-bony-fusion-of-the-distal-femoral-and-the-proximal-tibial-epiphyses-using-closest-to-bone-t1-tse-sequence
#20
Christian Ottow, Ronald Schulz, Heidi Pfeiffer, Walter Heindel, Andreas Schmeling, Volker Vieth
OBJECTIVES: To clarify the relevance of the bony fusion of the distal femoral and the proximal tibial epiphyses by means of magnetic resonance imaging (MRI), a prospective cross-sectional cohort study was performed with a special focus on a reliable determination of the 14th, 16th and 18th years of life. METHODS: We scanned 658 German volunteers in the age bracket 12-24 years using a 3.0 T MR-scanner and utilising a T1 turbo spin-echo sequence representing true bone anatomy...
December 2017: European Radiology
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