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https://www.readbyqxmd.com/read/28725932/dna-methylation-in-elovl2-and-c1orf132-correctly-predicted-chronological-age-of-individuals-from-three-disease-groups
#1
M Spólnicka, E Pośpiech, B Pepłońska, R Zbieć-Piekarska, Ż Makowska, A Pięta, J Karłowska-Pik, B Ziemkiewicz, M Wężyk, P Gasperowicz, T Bednarczuk, M Barcikowska, C Żekanowski, R Płoski, Wojciech Branicki
Improving accuracy of the available predictive DNA methods is important for their wider use in routine forensic work. Information on age in the process of identification of an unknown individual may provide important hints that can speed up the process of investigation. DNA methylation markers have been demonstrated to provide accurate age estimation in forensics, but there is growing evidence that DNA methylation can be modified by various factors including diseases. We analyzed DNA methylation profile in five markers from five different genes (ELOVL2, C1orf132, KLF14, FHL2, and TRIM59) used for forensic age prediction in three groups of individuals with diagnosed medical conditions...
July 19, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28707524/applicability-of-cameriere-s-and-drusini-s-age-estimation-methods-to-a-sample-of-turkish-adults
#2
Hatice Boyacioglu Dogru, Nihal Avcu, Nursel Akkaya, Humeyra Ozge Yilanci, Dincer Goksuluk
OBJECTIVES: The aim of this study was to investigate the applicability of Drusini's and Cameriere's methods to a sample of Turkish people. METHODS: Panoramic images of 200 individuals were allocated into two groups as study and test groups and examined by two observers. Tooth coronal indexes (TCI), which is the ratio between coronal pulp cavity height and crown height, were calculated in the mandibular first and second premolars and molars. Pulp/tooth area ratios (ARs) were calculated in the maxillary and mandibular canine teeth...
July 14, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28706489/difference-in-striae-periodicity-of-heilongjiang-and-singaporean-chinese-teeth
#3
Sharon H X Tan, Yu Fan Sim, Chin-Ying S Hsu
Striae periodicity refers to the number of cross-striations between successive lines of Retzius in tooth enamel. A regular time dependency of striae periodicity, known as the circaseptan interval, has been proposed. Previous studies on striae periodicity have been carried out on both modern and early humans given its potential applications in forensic age estimations and anthropology. Nevertheless, research comparing striae periodicities across gender groups and populations in different geographical locations, particularly in Asia, is lacking...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28691915/forensic-individual-age-estimation-with-dna-from-initial-approaches-to-methylation-tests
#4
REVIEW
A Freire-Aradas, C Phillips, M V Lareu
Individual age estimation is a key factor in forensic science analysis that can provide very useful information applicable to criminal, legal, and anthropological investigations. Forensic age inference was initially based on morphological inspection or radiography and only later began to adopt molecular approaches. However, a lack of accuracy or technical problems hampered the introduction of these DNA-based methodologies in casework analysis. A turning point occurred when the epigenetic signature of DNA methylation was observed to gradually change during an individual´s lifespan...
July 2017: Forensic Science Review
https://www.readbyqxmd.com/read/28677057/forensic-age-estimation-by-magnetic-resonance-imaging-of-the-knee-the-definite-relevance-in-bony-fusion-of-the-distal-femoral-and-the-proximal-tibial-epiphyses-using-closest-to-bone-t1-tse-sequence
#5
Christian Ottow, Ronald Schulz, Heidi Pfeiffer, Walter Heindel, Andreas Schmeling, Volker Vieth
OBJECTIVES: To clarify the relevance of the bony fusion of the distal femoral and the proximal tibial epiphyses by means of magnetic resonance imaging (MRI), a prospective cross-sectional cohort study was performed with a special focus on a reliable determination of the 14th, 16th and 18th years of life. METHODS: We scanned 658 German volunteers in the age bracket 12-24 years using a 3.0 T MR-scanner and utilising a T1 turbo spin-echo sequence representing true bone anatomy...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28634678/the-iliac-crest-in-forensic-age-estimation-evaluation-of-three-methods-in-pelvis-x-rays
#6
Viola Bartolini, Vilma Pinchi, Barbara Gualco, Stefano Vanin, Giusto Chiaracane, Giovanni D'Elia, Gian-Aristide Norelli, Martina Focardi
Age assessment in children and young adults is a relevant forensic issue. It is requested not only in evaluating criminal responsibility in youths without proper identification documents, often in relation to age thresholds, but also for release of a residency permit, and asylum seekers of minors. The analysis of the Risser sign and the iliac crest ossification process has been proposed as a useful tool for forensic age estimation. We evaluated the applicability of three different age estimation methods on a sample of 497 pelvic radiographs of Italian individuals between 10 and 25 years of age...
June 20, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28577061/chronology-of-mineralization-of-the-permanent-mandibular-second-molar-teeth-and-forensic-age-estimation
#7
Pedro Fins, Maria Lurdes Pereira, Américo Afonso, Daniel Pérez-Mongiovi, Inês Morais Caldas
Forensic age estimation frequently relies upon the chronology of mineralization of the third molar teeth. However, even when present, third molar teeth cannot always be used for estimating age in people who are classified as minors. Seconds molars develop earlier and in a more predictable way, and therefore are often more reliable for age estimation in this age group. This study aims to contribute to forensic age estimation using an age threshold of 14-years, studying the stages of development of permanent mandibular second molar teeth mineralization...
June 3, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28550762/forensic-age-estimation-by-morphometric-analysis-of-the-manubrium-from-3d-mr-images
#8
Naira P Martínez Vera, Johannes Höller, Thomas Widek, Bernhard Neumayer, Thomas Ehammer, Martin Urschler
Forensic age estimation research based on skeletal structures focuses on patterns of growth and development using different bones. In this work, our aim was to study growth-related evolution of the manubrium in living adolescents and young adults using magnetic resonance imaging (MRI), which is an image acquisition modality that does not involve ionizing radiation. In a first step, individual manubrium and subject features were correlated with age, which confirmed a statistically significant change of manubrium volume (Mvol:p<0...
May 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28511095/independent-validation-of-dna-based-approaches-for-age-prediction-in-blood
#9
Sohee Cho, Sang-Eun Jung, Sae Rom Hong, Eun Hee Lee, Ji Hyun Lee, Soong Deok Lee, Hwan Young Lee
Numerous molecular biomarkers have been proposed as predictors of chronological age. Among them, T-cell specific DNA rearrangement and DNA methylation markers have been introduced as forensic age predictors in blood because of their high prediction accuracy. These markers appear highly promising, but for better application to forensic casework sample analysis the proposed markers and genotyping methods must be tested further. In the current study, signal-joint T-cell receptor excision circles (sjTRECs) and DNA methylation markers located in the ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 genes were reanalyzed in 100 Korean blood samples to test their associations with chronological age, using the same analysis platform used in previous reports...
July 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28500091/forensic-age-estimation-using-the-medial-clavicular-epiphysis-a-study-review
#10
Mary B Buckley, Kevin R Clark
PURPOSE: To discuss current literature evaluating the medial clavicular epiphysis to assess an individual's age using various imaging modalities. METHODS: Four scholarly research databases were searched to find studies that examined living subjects. Several articles were included that used cadavers, and a textbook was used to detail the anatomy of the clavicle. Thirty-nine articles were analyzed. RESULTS: The literature indicated that several imaging modalities, including conventional radiography, computed tomography, magnetic resonance, and sonography, are being used to evaluate the medial clavicular epiphysis to estimate an individual's age in the forensic context...
May 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28486142/the-age-related-expression-decline-of-ercc1-and-xpf-for-forensic-age-estimation-a-preliminary-study
#11
Xiao-Dong Deng, Qin Gao, Wei Zhang, Bo Zhang, Ying Ma, Li-Xia Zhang, Cheer Muer, Ying Xie, Yun Liu
The age-related capacity decline of DNA damage repair in human peripheral blood has been demonstrated. Excision repair cross-complementation group1 (ERCC1) and Xeroderma pigmentosum complementation group F (XPF) were rate-limiting enzyme in nucleotide excision repair (NER) which was known as the most important DNA damage repair system. Consequently, we hypothesized that the expression and/or activity of ERCC1 and XPF may be associated with age. However, little was known about the quantitative relationship of ERCC1 and XPF expression levels with age...
July 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28482246/validation-of-third-molar-maturity-index-i3m-for-discrimination-of-juvenile-adult-status-in-south-indian-population
#12
Sudheer B Balla, Ivan Galic, Karunakar P, Stefano Vanin, Stefano De Luca, Roberto Cameriere
Deliberate falsification of age was considered to be one of the main reasons for forensic age estimation of the living individuals. This posed to be a challenging task during criminal and legal proceedings, and ultimate care must be taken not to classify juveniles as adults. Third molars are the only developing teeth during late adolescence and early adulthood. Our study was designed to analyze the usefulness of the third molar maturity index (I3M) specific cut-off value (I3M < 0.08) to discriminate adults (≥18 years) and juveniles (<18 years) in South Indian children...
July 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28439695/usefulness-of-telomere-length-in-dna-from-human-teeth-for-age-estimation
#13
Ana Belén Márquez-Ruiz, Lucas González-Herrera, Aurora Valenzuela
Age estimation is widely used to identify individuals in forensic medicine. However, the accuracy of the most commonly used procedures is markedly reduced in adulthood, and these methods cannot be applied in practice when morphological information is limited. Molecular methods for age estimation have been extensively developed in the last few years. The fact that telomeres shorten at each round of cell division has led to the hypothesis that telomere length can be used as a tool to predict age. The present study thus aimed to assess the correlation between telomere length measured in dental DNA and age, and the effect of sex and tooth type on telomere length; a further aim was to propose a statistical regression model to estimate the biological age based on telomere length...
April 24, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28407514/age-estimation-from-structural-changes-of-teeth-and-buccal-alveolar-bone-level
#14
K K Koh, J S Tan, P Nambiar, Norliza Ibrahim, Sunil Mutalik, Muhammad Khan Asif
Forensic odontology plays a vital role in the identification and age estimation of unknown deceased individuals. The purpose of this study is to estimate the chronological age from Cone-Beam Computed Tomography (CBCT) images by measuring the buccal alveolar bone level (ABL) to the cemento-enamel junction and to investigate the possibility of employing the age-related structural changes of teeth as studied by Gustafson. In addition, this study will determine the forensic reliability of employing CBCT images as a technique for dental age estimation...
May 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28254385/dna-methylation-based-forensic-age-prediction-using-artificial-neural-networks-and-next-generation-sequencing
#15
Athina Vidaki, David Ballard, Anastasia Aliferi, Thomas H Miller, Leon P Barron, Denise Syndercombe Court
The ability to estimate the age of the donor from recovered biological material at a crime scene can be of substantial value in forensic investigations. Aging can be complex and is associated with various molecular modifications in cells that accumulate over a person's lifetime including epigenetic patterns. The aim of this study was to use age-specific DNA methylation patterns to generate an accurate model for the prediction of chronological age using data from whole blood. In total, 45 age-associated CpG sites were selected based on their reported age coefficients in a previous extensive study and investigated using publicly available methylation data obtained from 1156 whole blood samples (aged 2-90 years) analysed with Illumina's genome-wide methylation platforms (27K/450K)...
May 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28123278/cementum-as-an-age-determinant-a-forensic-view
#16
Godishala Swamy Sugunakar Raju, Muddana Keerthi, Surapaneni Rateesh Kumar Nandan, Thokala Madhusudan Rao, Pavan G Kulkarni, Dorankula Shyam Prasad Reddy
CONTEXT: Forensic age estimation (FAE) defines an expertise in forensic medicine, which aims to define in the most accurate way to determine the unknown chronological age of the person involved in judicial or legal proceedings. Dental cementum is a vital tissue which demonstrates continuous apposition throughout the life of the tooth. This appositional changes of cementum helps in approximation of age inforensic investigations. AIMS: To correlate age by measuring the overlap or coronal migration of thecementum at thecementoenamel junction (CEJ) and the thickness of the cementum at the apical third of the root...
September 2016: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28032243/the-role-of-forensic-medicine-and-forensic-dentistry-in-estimating-the-chronological-age-of-living-individuals-in-hamburg-germany
#17
Hussam Mansour, Andreas Fuhrmann, Ioana Paradowski, Eilin Jopp van Well, Klaus Püschel
Age estimation represents one of the primary responsibilities of forensic medicine and forensic dentistry. It is an integral procedure aiming to estimate the chronological age of an individual, whose age is either unknown or doubtful, by means of assessing the stage of dental, skeletal, and physical development. The present publication reviews the methods and procedures used in estimating the age of young living individuals as well as the experiences of the Institute of Legal Medicine in Hamburg-Eppendorf, Germany, during the last 25 years...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27981359/evaluation-of-the-ossification-of-the-medial-clavicle-according-to-the-kellinghaus-substage-system-in-identifying-the-18-year-old-age-limit-in-the-estimation-of-forensic-age-is-it-necessary
#18
Murat Serdar Gurses, Nursel Turkmen Inanir, Esra Soylu, Gokhan Gokalp, Elif Kir, Recep Fedakar
The evaluation of the ossification of the medial clavicular epiphysis being part of an assigned expert approach according to standard plays an important role within civil and criminal proceedings in assessing whether a person has reached her/his 19th or 22nd year of age. Evaluation of the medial clavicular epiphysis with thin-section CT is one of the methods recommended by the Study Group on Forensic Age Diagnostics of the German Association of Forensic Medicine. In this retrospective study, we evaluated the thin-section CT (section thickness of 0...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27930820/a-bayesian-approach-to-age-at-death-estimation-from-osteoarthritis-of-the-shoulder-in-modern-north-americans
#19
Ashley L Brennaman, Kim R Love, Jonathan D Bethard, James T Pokines
Osteoarthritis (OA) is a marker of degeneration within the skeleton, frequently associated with age. This study quantifies the correlation between OA and age-at-death and investigates the utility of shoulder OA as a forensic age indicator using a modern North American sample of 206 individuals. Lipping, surface porosity, osteophyte formation, eburnation, and percentage of joint surface affected were recorded on an ordinal scale and summed to create composite scores that were assigned a specific phase. Spearman's correlation indicated a positive relationship between each composite score and age (right shoulder = 0...
May 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27924404/magnetic-resonance-imaging-of-the-distal-radial-epiphysis-a-new-criterion-of-maturity-for-determining-whether-the-age-of-18-has-been-completed
#20
M Timme, C Ottow, R Schulz, H Pfeiffer, W Heindel, V Vieth, A Schmeling, S Schmidt
To improve the accuracy of forensic age estimation where there is no legal basis for carrying out x-ray examinations, it would be useful to establish non-x-ray imaging techniques. The objective of this study was to provide reference data for the magnetic resonance imaging-based evaluation of the ossification stage of the distal radius. Furthermore, we tested a new criterion of the maturity of the distal radial epiphysis for determining whether an individual has completed the age of 18. We investigated 668 MRI scans of the distal radial epiphysis from 333 female and 335 male subjects ranging in age from 12 to 24...
March 2017: International Journal of Legal Medicine
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