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https://www.readbyqxmd.com/read/29245041/stability-of-postmortem-methemoglobin-artifactual-changes-caused-by-storage-conditions
#1
Vincent Varlet, Elenore Ryser, Marc Augsburger, Cristian Palmiere
Hemoglobin is the protein in red blood cells that carries and distributes oxygen to the body. Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin (MetHb), a form of hemoglobin (Hb), is produced from either inadequate MetHb reductase activity or too much MetHb production or by exposure to oxidizing agents. This could lead to anoxia and death if it is not treated. However, this parameter has not been investigated as a valid post-mortem indicator because random MetHb levels have been observed in various studies: MetHb increases can be observed due to autoxidation during storage, and MetHb decreases can be observed due to MetHb reductase or microbial activity in post-mortem samples...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29244156/percutaneous-increase-of-mitral-leaflet-coaptation-length-after-mitral-valve-repair-results-from-a-preclinical-study
#2
Piergiorgio Tozzi, Giuseppe Siniscalchi, Enrico Ferrari, Matthias Kirsch, Daniel Hayoz
OBJECTIVES: The failure of mitral repairs can be the result of inadequate leaflet coaptation length (CL< 8 mm at the A2-P2 level). A new annuloplasty ring conceived by the authors enables post-surgical CL increase using percutaneous balloon catheter technology. We conducted preclinical studies to assess the in vivo feasibility of the procedure and the safety of the postimplant deformable mitral ring. METHODS: The new annuloplasty ring allows the percutaneous and progressive displacement of each of the 3 anatomical regions of the posterior mitral annulus towards the anterior...
December 13, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29243077/pulmonary-embolus-as-cause-of-death-in-an-adolescent-demonstration-on-postmortem-ct
#3
Mary P Harty, H Theodore Harcke, Sharon W Gould, Adrienne Sukula-Perlman
Computed tomography (CT) is widely accepted in adult forensic death investigations (determination of cause and manner of death) but is only beginning to play a larger role in the cause of death determination in infants and children. We present a case of an adolescent with nephrotic syndrome who sustained cardiac arrest and died in the emergency department. A postmortem CT was requested by the state Office of the Medical Examiner as part of the medicolegal death investigation. Postmortem CT showed a saddle pulmonary embolus that was confirmed on conventional autopsy, demonstrating a natural manner of death...
December 14, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29242411/a-retrospective-study-of-331-deaths-in-children-with-severe-hand-foot-and-mouth-disease-in-guangxi-china
#4
Zhi-Yong Yang, Xiu-Qi Chen, Dan Sun, Dan Wei
OBJECTIVE: To analyze the clinical features of children with hand foot and mouth disease (HFMD) who died. METHODS: 331 deaths due to HFMD were included in this retrospective study; 15 autopsies were performed. RESULTS: Most cases were seen in children aged below 3 years, and with enterovirus 71 infection (91%). The mean (SD) duration of HFMD from onset to death was 3.7(2.9) days. The mean (SD) age of fast progressors (from onset to death less than 4 days) was 17...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29242004/point-of-care-devices-using-disease-biomarkers-to-diagnose-neurodegenerative-disorders
#5
REVIEW
Ting-Yen Wei, Yun Fu, Kuo-Hsuan Chang, Kun-Ju Lin, Yu-Jen Lu, Chao-Min Cheng
Neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases are highly prevalent and immensely destructive to the health and well-being of individuals and their families across the globe. Neurodegenerative diseases are characterized by the gradual loss of neural tissue in the central nervous system. Clearly, early diagnosis of the onset of neurodegeneration is vital and beneficial. Current diagnostic methods rely heavily on symptoms or autopsy results, thus overlooking early diagnosis, the only opportunity for amelioration...
December 11, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29241093/quantitative-analysis-of-drugs-in-hair-by-uhplc-high-resolution-mass-spectrometry
#6
Robert Kronstrand, Malin Forsman, Markus Roman
Liquid chromatographic methods coupled to high resolution mass spectrometry are increasingly used to identify compounds in various matrices including hair but there are few recommendations regarding the parameters and their criteria to identify a compound. In this study we present a method for the identification and quantification of a range of drugs and discuss the parameters used to identify a compound with high resolution mass spectrometry. Drugs were extracted from hair by incubation in a buffer:solvent mixture at 37°C during 18h...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29240237/non-isolated-diaphragmatic-hernia-in-simpson-golabi-behmel-syndrome
#7
Karen Chong, Maha Saleh, Marie Injeyan, Ioana Miron, Katherine Fong, Patrick Shannon
OBJECTIVE: Congenital diaphragmatic hernia (CDH) is associated with Simpson-Golabi-Behmel syndrome (SGBS), but few cases diagnosed prenatally have been reported. The aim of this series is to highlight the association of non-isolated CDH with SGBS type I on prenatal ultrasound and emphasize the importance of genetic testing, fetal autopsy and family history in confirming this diagnosis. METHOD: Retrospective review of three cases of SGBS type I in a single tertiary care centre...
December 14, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29239466/rupture-of-the-myocardium-in-autopsied-mi-hearts
#8
Valesca Bizinoto Monteiro, Bianca Gonçalves Silva Torquato, Guilherme Ribeiro Juliano, Bárbara Cecílio da Fonseca, Flávia Aparecida de Oliveira, Daniel Ferreira da Cunha, Camila Lourencini Cavellani, Luciano Alves Matias da Silveira, Mara Lúcia da Fonseca Ferraz, Vicente de Paula Antunes Teixeira, Edson Luiz Fernandes
Although myocardial rupture occurs in only 2% to 4% of cases of acute myocardial infarction (AMI), there is a high mortality rate due to acute cardiogenic shock. We present the anatomopathological findings of three cases of myocardial rupture in autopsied hearts in the last 30 years, with a diagnosis of cardiac rupture in acute myocardial infarction. In these 30 years the percentage of AMI with myocardial rupture was 0.2%. Risk factors for post-AMI myocardial rupture include older age, atherosclerosis, diabetes mellitus and systemic arterial hypertension...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29237689/technical-advances-for-the-clinical-genomic-evaluation-of-sudden-cardiac-death-verification-of-next-generation-sequencing-panels-for-hereditary-cardiovascular-conditions-using-formalin-fixed-paraffin-embedded-tissues-and-dried-blood-spots
#9
Linnea M Baudhuin, Charles Leduc, Laura J Train, Rajeswari Avula, Michelle L Kluge, Katrina E Kotzer, Peter T Lin, Michael J Ackerman, Joseph J Maleszewski
BACKGROUND: Postmortem genetic testing for heritable cardiovascular (CV) disorders is often lacking because ideal specimens (ie, whole blood) are not retained routinely at autopsy. Formalin-fixed paraffin-embedded tissue (FFPET) is ubiquitously collected at autopsy, but DNA quality hampers its use with traditional sequencing methods. Targeted next-generation sequencing may offer the ability to circumvent such limitations, but a method has not been previously described. The primary aim of this study was to develop and evaluate the use of FFPET for heritable CV disorders via next-generation sequencing...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29236880/urban-violence-is-the-biggest-cause-of-fatal-work-related-accidents-in-brazil
#10
Ricardo Cordeiro, Verônica Gronau Luz, Élida Azevedo Hennington, Ana Cláudia Alves Martins, Luís Fernando Tófoli
OBJECTIVE: To quantify the occurrence of deaths directly associated with urban violence among fatal work-related accidents. METHODS: Verbal autopsies were performed with the relatives and coworkers of residents of Campinas, state of São Paulo, Brazil, who died from external causes in 2015. We have also analyzed police reports and reports of the Legal Medical Institute related to these deaths. RESULTS: We have identified 82 fatal work-related accidents in Campinas in 2015, of which 25 were murders, 35 were traffic accidents not directly related to work activities, and three were suicides at work...
December 11, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29236741/social-determinants-of-adult-mortality-from-non-communicable-diseases-in-northern-ethiopia-2009-2015-evidence-from-health-and-demographic-surveillance-site
#11
Semaw Ferede Abera, Alemseged Aregay Gebru, Hans Konrad Biesalski, Gebisa Ejeta, Andreas Wienke, Veronika Scherbaum, Eva Johanna Kantelhardt
INTRODUCTION: In developing countries, mortality and disability from non-communicable diseases (NCDs) is rising considerably. The effect of social determinants of NCDs-attributed mortality, from the context of developing countries, is poorly understood. This study examines the burden and socio-economic determinants of adult mortality attributed to NCDs in eastern Tigray, Ethiopia. METHODS: We followed 45,982 adults implementing a community based dynamic cohort design recording mortality events from September 2009 to April 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29236126/-structural-damage-after-shoulder-dislocation-and-development-of-surgical-treatment-from-a-historical-perspective
#12
REVIEW
P Habermeyer, P Magosch
In the nineteenth century there was a high incidence of habitual shoulder instability caused by epileptic seizures and accompanied by therapeutic dilettantism, which led to socioeconomic problems in the working population. In the preradiography era the pathomechanism of shoulder dislocation was only known on the basis of cadaver studies and autopsy findings. The underlying structural disorders of habitual shoulder instability in the Bismarck era were published by Malgaigne, Broca and Hartmann. In1898 the first surgical reconstructive stabilization procedure for habitual shoulder dislocation was performed by Wilhelm Müller in Rostock...
December 13, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29235141/pseudomesotheliomatous-carcinoma-of-the-pleura-an-autopsy-case-of-metastasis-from-a-g-csf-producing-anaplastic-carcinoma-of-the-pancreas
#13
Yui Hattori, Kazuhiro Sentani, Takuya Hattori, Naohide Oue, Wataru Yasui
Pseudomesotheliomatous carcinoma is a malignant tumor that extends along the pleura mimicking malignant mesothelioma. An 81-year-old male patient presented to our hospital with epigastralgia, and abdominal computed tomography (CT) showed a 36-mm tumor in the pancreatic tail. The laboratory data revealed a high leukocyte count (>44 000/μL). Chest CT showed left pleural thickening with pleural effusion. The cancer showed a poor response to chemotherapy, and the patient died of respiratory failure at 5 months after the onset of disease...
December 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29232706/biventricular-differences-in-%C3%AE-adrenergic-receptor-signaling-following-burn-injury
#14
Ashley N Guillory, Robert P Clayton, Anesh Prasai, Amina El Ayadi, David N Herndon, Celeste C Finnerty
Burn injury detrimentally affects the myocardium, primarily due to over-activation of β-adrenergic receptors (β-AR). Autopsy reports from our institution reveal that patients often suffer from right ventricle (RV) failure. Since burn injury affects β-AR signaling in the left ventricle (LV), we proposed that β-AR signaling may also be altered in the RV. A rodent model with a scald burn of 60% of the total body surface area was used to test this hypothesis. Ventricles were isolated 7 days post-burn. We examined the expression of β-ARs via Western blotting and the mRNA expression of downstream signaling proteins via qRT-PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29232618/pediatric-medicolegal-autopsy-in-france-a-forensic-histopathological-approach
#15
Clémence Delteil, Lucile Tuchtan, Julia Torrents, Caroline Capuani, Marie-Dominique Piercecchi-Marti
The aim of postmortem medicolegal examination in pediatric death is primarily to establish the circumstances and causes of death and to exclude child abuse. In France, pediatric death is systematically documented by medicolegal or medical autopsy. In case of medicolegal autopsy, the complementary examinations, requested and financed by justice, are rarely limited to a histopathological examination. However in medical autopsies other tools are available to the pathologist as toxicology, biochemistry and molecular biology...
December 5, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29231840/autopsy-learning-module-a-tool-for-assessing-self-reflection-and-practice-improvement-competency
#16
Mohammad Saud Khan, William Barnett, Amira Gohara, Jacob Torrison, Christian Coletta, Ragheb Assaly
No abstract text is available yet for this article.
December 11, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/29231013/-diagnostic-value-of-postmortem-ct-angiography-in-coronary-atherosclerosis
#17
H Qian, Y Shao, Z D Li, D H Zou, Z Q Qin, L Wan, Y J Chen
OBJECTIVES: To explore the application value of postmortem computed tomography (CT) angiography on diagnosis of coronary atherosclerotic stenosis degree. METHODS: Based on the previous experimental results, the postmortem CT angiography device of human isolated heart was improved. Different coronary atherosclerotic stenosis degree of sudden death cases was selected. Before the cardiac anatomy, hearts were removed out completely and CT angiography was performed immediately...
April 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29230996/-research-progress-of-the-correlation-between-caveolin-and-unexpected-sudden-cardiac-death
#18
REVIEW
F Y Wu, L L Gai, X P Kong, B Hao, E W Huang, H Shi, L H Sheng, L Quan, S P Liu, B Luo
Due to the negative autopsy and without cardiac structural abnormalities, unexpected sudden cardiac death (USCD) is always a tough issue for forensic pathological expertise. USCD may be associated with parts of fatal arrhythmic diseases. These arrhythmic diseases may be caused by disorders of cardiac ion channels or channel-related proteins. Caveolin can combine with multiple myocardial ion channel proteins through its scaffolding regions and plays an important role in maintaining the depolarization and repolarization of cardiac action potential...
June 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29229509/diagnosis-of-congenital-abnormalities-with-post-mortem-ultrasound-in-perinatal-death
#19
L Tuchtan, E Lesieur, C Bartoli, C Delteil, L Sarda-Quarello, J Torrents, S Sigaudy, M-D Piercecchi, G Gorincour
PURPOSE: To determine the sensitivity and specificity of post-mortem ultrasound in the diagnosis of major congenital abnormalities of fetuses using conventional autopsy as the standard of reference. MATERIAL AND METHODS: All fetuses coming from terminations of pregnancy or intrauterine fetal deaths in a single institution were included. A total of 75 fetuses were included during the study period. The results of post-mortem ultrasound examinations were compared to those of conventional autopsy that served as standard of reference...
December 8, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29228513/an-analysis-of-the-morbidity-and-mortality-of-diabetes-mellitus-in-a-forensic-context
#20
Chong Zhou, Roger W Byard
To investigate the spectrum of diseases seen in diabetes mellitus in a forensic context, all autopsy reports of diabetic individuals who presented to Forensic Science, South Australia (FSSA), over a 5-year period from 2005 to 2009 were studied. The leading cause of death was cardiovascular disease (55.0%), followed by unnatural deaths (15.4%) and infections (9.4%). In type 1 diabetics, principal causes of death included cardiovascular disease (44.7%), acute metabolic complications (18.7%), unnatural deaths (17...
December 11, 2017: Journal of Forensic Sciences
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