keyword
https://read.qxmd.com/read/38528172/efficacy-and-safety-of-cryoablation-compared-with-cooled-radiofrequency-ablation-of-genicular-nerves-in-advanced-osteoarthritis-of-the-knee-a-study-protocol-of-single-centric-assessor-blinded-randomized-parallel-group-non-inferiority-study
#21
JOURNAL ARTICLE
Gautam Das, Amol Singam, Vivek Chakole, Sushpa Das, Vikas Sharma
PURPOSE: In patients with symptomatic osteoarthritis knee (OAK), cryoneurolysis (CRYO) and cooled radiofrequency ablation (C-RFA) are reported to be effective and safe; however, they have not been compared directly. The objective of this study is to compare CRYO and C-RFA of the genicular nerve (GN) in terms of efficacy and safety profile in patients with Kellgren and Lawrence (KL) grade ≥ 3 OAK. METHODS: This single-centric, assessor-blinded, randomized, parallel-group, non-inferiority study will include 80 patients with KL grade ≥ 3 OAK...
March 25, 2024: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/38528161/preoperative-fatty-infiltration-of-paraspinal-muscles-assessed-by-mri-is-associated-with-less-improvement-of-leg-pain-2%C3%A2-years-after-surgery-for-lumbar-spinal-stenosis
#22
JOURNAL ARTICLE
Hasan Banitalebi, Erland Hermansen, Christian Hellum, Ansgar Espeland, Kjersti Storheim, Tor Åge Myklebust, Kari Indrekvam, Helena Brisby, Clemens Weber, Masoud Anvar, Jørn Aaen, Anne Negård
PURPOSE: Fatty infiltration (FI) of the paraspinal muscles may associate with pain and surgical complications in patients with lumbar spinal stenosis (LSS). We evaluated the prognostic influence of MRI-assessed paraspinal muscles' FI on pain or disability 2 years after surgery for LSS. METHODS: A muscle fat index (MFI) was calculated (by dividing signal intensity of psoas to multifidus and erector spinae) on preoperative axial T2-weighted MRI of patients with LSS...
March 25, 2024: European Spine Journal
https://read.qxmd.com/read/38527988/magnetic-resonance-imaging-combined-with-histological-evaluation-of-repair-process-using-the-microfracture-technique-in-an-association-of-osteocartilaginous-and-meniscal-surgically-induced-lesions-of-the-knee-in-vivo-experiment-on-a-rabbit-model
#23
JOURNAL ARTICLE
Jenel Marian Pătraşcu, Sorin Florescu, Silviu Brad, Bogdan Corneliu Andor, Iosif Ilia, Ştefan Iulian Stănciugelu, Romeo Teodor Cristina
The present research study aimed to assess magnetic resonance imaging (MRI) changes and histological findings in the therapeutic effects of microfractures in the treatment of complex animal knee lesions resulting from osteochondral and meniscal defects resulting from non-total meniscectomies. The anterior cruciate ligament lesions are also proven to facilitate the development of osteoarthritis in the knee and worsen the prognosis. Surgery was performed on the right knee joint of 22 male rabbits in order to partially remove the anterior horn of the internal meniscus and to induce an osteochondral defect at the level of the internal femoral condyle...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38526619/the-influence-of-depression-on-clinical-outcomes-of-total-shoulder-arthroplasty-a-systematic-review
#24
REVIEW
Victoria E Bindi, Keegan M Hones, Bradley S Schoch, Hailey L Hampton, Thomas W Wright, Joseph J King, Kevin A Hao
PURPOSE: Much of the current literature on total shoulder arthroplasty (TSA) has assessed the impact of preoperative medical comorbidities on postoperative clinical outcomes. The literature concerning the impact of psychological disorders such as depression on TSA has increased in popularity in recent years, but there lacks a thorough review of the influence of depression on postoperative pain and functional outcomes. METHODS: We queried PubMed/MEDLINE and identified six clinical studies that evaluated the influence of a psychiatric diagnosis of depression on patient outcomes after TSA...
March 25, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38525999/polyacrylamide-gel-versus-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis-a-randomised-controlled-study
#25
JOURNAL ARTICLE
Henning Bliddal, Jannie Beier, Andreas Hartkopp, Philip G Conaghan, Marius Henriksen
OBJECTIVES: To assess non-inferiority of intra-articular injectable polyacrylamide hydrogel (iPAAG) to hyaluronic acid (HA) on symptomatic benefit in individuals with knee osteoarthritis (OA). METHODS: This randomised, controlled, multi-centre trial recruited adults with symptomatic and radiographic knee OA from 3 clinical rheumatology sites in Denmark; two private clinics and one public hospital department. Participants were randomised 1:1 to receive a single intra-articular 6 mL injection of either HA or iPAAG on an outpatient basis...
March 19, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38525952/postinjection-protocols-following-platelet-rich-plasma-administration-for-knee-osteoarthritis-a-systematic-review
#26
JOURNAL ARTICLE
Oscar Paul Levine, Koushik Kondapi, Vehniah Kristin Tjong, Chetan Gohal
OBJECTIVE: Platelet-rich plasma (PRP) use in treating orthopedic conditions has increased, yet evidence of its clinical efficacy is inconsistent and limited by heterogeneity in osteoarthritis (OA) severity, PRP preparations and protocols, and clinical outcome measurement. This review aims to characterize the variations in postinjection protocols in studies assessing the clinical efficacy of PRP for knee OA. LITERATURE SURVEY: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
March 25, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
https://read.qxmd.com/read/38525551/increasing-burden-of-osteoarthritis-in-china-trends-and-projections-from-the-global-burden-of-disease-study-2019
#27
JOURNAL ARTICLE
Shugang Hu, Yongwei Li, Xinyi Zhang, Tariq Alkhatatbeh, Wei Wang
BACKGROUND This study aimed to evaluate the epidemiology of osteoarthritis in China in a comprehensive and reliable way, to project its future epidemiological patterns, and to mitigate its health hazards. MATERIAL AND METHODS Data were extracted and analyzed from the Global Burden of Diseases Study 2019. Trends in osteoarthritis epidemiology were explored using joinpoint regression analysis. Additionally, we analyzed dynamic trends using the sociodemographic index (SDI) of China. To assess and predict the epidemiology of osteoarthritis from 2020 to 2039, we used both the Bayesian age-period-cohort model and Nordpred model...
March 13, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38525288/degenerative-meniscus-tears-treated-nonoperatively-with-platelet-rich-plasma-yield-variable-clinical-and-imaging-outcomes-a-systematic-review
#28
REVIEW
Varun Gopinatth, Anjay K Batra, Jorge Chahla, Matthew V Smith, Matthew J Matava, Robert H Brophy, Derrick M Knapik
PURPOSE: To perform a systematic review on clinical and radiologic outcomes for meniscus tears treated nonoperatively with platelet-rich plasma (PRP). METHODS: A literature search was performed according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using keywords and Boolean operators in SCOPUS, PubMed, Medline, and the Cochrane Central Register for Controlled Trials in April 2023. Inclusion criteria were limited to Level I to IV human studies reporting on outcomes of meniscus tears treated nonoperatively with PRP...
April 2024: Arthroscopy, sports medicine, and rehabilitation
https://read.qxmd.com/read/38524702/minimally-invasive-tibiotalocalcaneal-arthrodesis-with-blocked-retrograde-intramedullary-nail-report-of-three-cases
#29
JOURNAL ARTICLE
Fernando Delmonte Moreira, Jorge Eduardo de Schoucair Jambeiro, Antero Tavares Cordeiro, José Augusto Oliveira, Felipe Fernandes Leão, Alex Guedes
Ankle osteoarthritis (AOA) is associated with pain and variable functional limitation, demanding clinical treatment and possible surgical indication when conservative measures are ineffective - arthrodesis has been the procedure of choice, because it reduces pain, restores joint alignment and makes the segment stable, preserving gait. The present study reports 3 cases (3 ankles) of male patients between 49 and 63 years old, with secondary AOA, preoperative American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS AHS) of 27 to 39 points, treated by minimally invasive tibiotalocalcaneal arthrodesis using blocked retrograde intramedullary nail...
February 2024: Revista Brasileira de Ortopedia
https://read.qxmd.com/read/38524622/elucidating-cyathula-officinals-mechanism-in-osteoarthritis-treatment-network-pharmacology-and-empirical-evidence-on-anti-inflammatory-actions
#30
JOURNAL ARTICLE
Zhicheng Yao, Fengping Gan, Yuqing Zeng, Litong Ren, Yirong Zeng
In this study, we explored the therapeutic potential of Cyathula Officinals (CNX) in Knee Osteoarthritis (KOA) treatment. Utilizing network pharmacology and in vitro experiments, we identified active ingredients, action targets and pathways in CNX. Our analysis, integrating databases like TCMSP, SwissTarget Prediction, Genecards, CTD, STRING, and DAVID, highlighted 396 action targets and 283 disease targets, pinpointing 64 intersection genes linked to KOA. The significant involvement of the MAPK and NF-κB pathways in CNX's anti-inflammatory action was validated through qPCR, which might underlie CNX's efficacy in inhibiting chondrocyte apoptosis and IL-6 expression...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524363/no-significant-clinical-differences-between-native-or-reduced-posterior-tibial-slope-in-kinematically-aligned-total-knee-replacement-with-posterior-cruciate-retaining
#31
JOURNAL ARTICLE
Giorgio Cacciola, Fortunato Giustra, Francesco Bosco, Daniele Vezza, Francesco Pirato, Lorenzo Braconi, Salvatore Risitano, Marcello Capella, Alessandro Massè, Luigi Sabatini
AIMS & OBJECTIVES: Total knee arthroplasty (TKA) is a common surgical procedure for end-stage knee osteoarthritis. However, conventional alignment techniques may lead to postoperative dissatisfaction in up to 20% of cases. Kinematic alignment (KA) has emerged as a new philosophy to restore the native joint line and achieve more natural kinematics. Preserving the posterior tibial slope (PTS) and posterior cruciate ligament (PCL) is crucial to maintaining the pre-arthritic joint line and improving knee kinematics...
August 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38524267/can-we-achieve-pain-stratification-in-musculoskeletal-conditions-implications-for-clinical-practice
#32
REVIEW
Nidhi Sofat, Andrew Lambarth
In the last few years there has been an increased appreciation that pain perception in rheumatic and musculoskeletal diseases (RMDs) has several mechanisms which include nociceptive, inflammatory, nociplastic and neuropathic components. Studies in specific patient groups have also demonstrated that the pain experienced by people with specific diagnoses can present with distinctive components over time. For example, the pain observed in rheumatoid arthritis has been widely accepted to be caused by the activation of nociceptors, potentiated by the release of inflammatory mediators, including prostaglandins, leukotrienes and cytokine networks in the joint environment...
2024: Front Pain Res (Lausanne)
https://read.qxmd.com/read/38524044/naturopathic-interventions-for-reduction-of-perceived-pain-in-patients-suffering-from-arthritis-a-systematic-review-and-meta-analysis
#33
REVIEW
Himel Mondal, Satyalakshmi Komarraju, Sathyanath D, Shrikanth Muralidharan
Arthritis affects millions of lives with its pervasive effects on physical health and quality of life. Addressing the complexities of managing symptoms such as swelling, inflammation, and pain requires prolonged treatment. Naturopathy is a treatment method that enhances the body's innate ability to restore optimal health through a holistic approach including natural products and lifestyle modifications. This systematic review addresses the intersection of naturopathy and arthritis treatment to provide current evidence about its potential benefits...
February 2024: Curēus
https://read.qxmd.com/read/38524005/navigating-the-therapeutic-landscape-a-comprehensive-review-of-platelet-rich-plasma-and-bone-marrow-aspirate-concentrate-in-knee-osteoarthritis
#34
REVIEW
Prashanth Balusani, Sandeep Shrivastava, Aditya Pundkar, Prathamesh Kale
This comprehensive review provides an in-depth analysis of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) as potential treatments for knee osteoarthritis. It explores their mechanisms of action, clinical efficacy, safety considerations, and the importance of personalised treatment approaches. The review highlights promising findings regarding the ability of PRP and BMAC to alleviate symptoms, improve joint function, and potentially slow disease progression. It emphasises the need for further research into long-term outcomes, direct comparative studies, protocol standardisation, biomarker identification, and cost-effectiveness assessments to enhance clinical practice...
February 2024: Curēus
https://read.qxmd.com/read/38523709/multimorbidity-in-atherosclerotic-cardiovascular-disease-and-its-associations-with-adverse-cardiovascular-events-and-healthcare-costs-a-real-world-evidence-study
#35
JOURNAL ARTICLE
Dingwei Dai, Joaquim Fernandes, Xiaowu Sun, Laura Lupton, Vaughn W Payne, Alexandra Berk
Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality and disability in the United States and worldwide. Objective: To assess the multimorbidity burden and its associations with adverse cardiovascular events (ACE) and healthcare costs among patients with ASCVD. Methods: This is a retrospective observational cohort study using Aetna claims database. Patients with ASCVD were identified during the study period (1/1/2018-10/31/2021). The earliest ASCVD diagnosis date was identified as the index date...
2024: Journal of health economics and outcomes research
https://read.qxmd.com/read/38523481/clinical-outcomes-of-different-management-techniques-for-medial-meniscal-type-3-ramp-lesions-in-anterior-cruciate-ligament-reconstruction-a-comparative-analysis-between-all-inside-repair-suture-hook-repair-and-lesions-left-in-situ
#36
JOURNAL ARTICLE
Adrien Saint-Etienne, Rayane Benhenneda, Thais Dutra Vieira, Jean-Marie Fayard, Mathieu Thaunat
BACKGROUND: There is ongoing debate about the best way to manage ramp lesions at the time of anterior cruciate ligament (ACL) reconstruction (ACLR). Type 3 lesions are not visible by the transnotch approach without superior debridement, making the management debate even more problematic. PURPOSE/HYPOTHESIS: The purpose of this study was to evaluate the rate of secondary surgical interventions according to the management method of a type 3 ramp lesion concomitant with primary ACLR...
March 25, 2024: American Journal of Sports Medicine
https://read.qxmd.com/read/38523473/influence-of-concomitant-meniscal-allograft-transplantation-on-midterm-outcomes-after-osteochondral-allograft-transplantation-a-comparative-matched-pair-analysis
#37
JOURNAL ARTICLE
Martin Husen, Allen S Wang, Bruce A Levy, Daniël B F Saris, Michael J Stuart, Aaron J Krych
BACKGROUND: Osteochondral allograft transplantation (OCAT) is an accepted knee joint-preserving treatment strategy for focal osteochondral lesions that is often conducted in combination with meniscal allograft transplantation (MAT). Despite its frequent and simultaneous utilization, there remains a lack in the literature reporting on outcomes and failure rates after concomitant procedures. PURPOSE: To determine (1) the midterm clinical success rate after OCAT+MAT in comparison with a matched-pair cohort undergoing isolated OCAT, (2) whether patient-specific and procedural variables influence the risk of failure, and (3) patient-reported outcome measures over time...
March 25, 2024: American Journal of Sports Medicine
https://read.qxmd.com/read/38523250/gait-alterations-associated-with-worsening-knee-pain-and-physical-function-a-machine-learning-approach-with-wearable-sensors-in-the-multicenter-osteoarthritis-study
#38
JOURNAL ARTICLE
Kathryn L Bacon, David T Felson, S Reza Jafarzadeh, Vijaya B Kolachalama, Jeffrey M Hausdorff, Eran Gazit, Joshua J Stefanik, Patrick Corrigan, Neil A Segal, Cora E Lewis, Michael C Nevitt, Deepak Kumar
OBJECTIVES: The objective of this study is to identify gait alterations related to worsening knee pain, and to worsening physical function, using machine learning approaches applied to wearable-sensor derived data from a large observational cohort. METHODS: Participants in the Multicenter Osteoarthritis Study (MOST) completed a 20-meter walk test wearing inertial sensors on their lower back and ankles. Parameters describing spatiotemporal features of gait were extracted from this data...
March 24, 2024: Arthritis Care & Research
https://read.qxmd.com/read/38522778/patient-reported-outcomes-following-total-shoulder-arthroplasty-and-hemiarthroplasty-an-analysis-of-data-from-the-national-joint-registry
#39
JOURNAL ARTICLE
Andrew R Davies, Sanjeeve Sabharwal, Alexander D Liddle, Bernarda Zamora-Talaya, Amar Rangan, Peter Reilly
INTRODUCTION: Total shoulder arthroplasty (TSA) and hemiarthroplasty (HA) are used in the management of end stage glenohumeral arthritis. Improvement in shoulder function and resolution of symptoms are high priorities for patients. The aim of this study was to compare patient-reported outcome measures (PROMs) following TSA and HA. METHOD: Records from the National Joint Registry of England, Wales, Northern Ireland and the Isle of Man were linked to the PROMs dataset...
March 22, 2024: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/38522777/mid-term-follow-up-of-the-nexel-total-elbow-arthroplasty
#40
JOURNAL ARTICLE
Adil Shahzad Ahmed, Thomas Clifton, Kushalappa Subbiah, Milos Spasojevic, Allan Young, Benjamin Cass, Andréanne Marmen, Raymond Yu, Codey Burton, Margaret M Smith, Jeffery Hughes
INTRODUCTION: Aseptic loosening is one of the most common complications of total elbow arthroplasty (TEA). Modern implants, such as the Nexel, have been designed in an attempt to decrease loosening. The present study aims to report implant survivorship, radiographic assessment of loosening and lucency, and patient-reported outcome measures (PROMs) in patients treated with the Nexel TEA at mid-term follow-up. METHODS: Consecutive series of adult patients underwent TEA using the Nexel by a single surgeon via standardized technique...
March 22, 2024: Journal of Shoulder and Elbow Surgery
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