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Clinical Osteoarthritis

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https://www.readbyqxmd.com/read/29352686/interobserver-and-intraobserver-reliability-of-computed-tomography-based-three-dimensional-preoperative-planning-for-primary-total-knee-arthroplasty
#1
Michiaki Miura, Shigeo Hagiwara, Junichi Nakamura, Yasushi Wako, Yuya Kawarai, Seiji Ohtori
BACKGROUND: Preoperative planning is an important factor for total knee arthroplasty (TKA). The aim of this study is to document the interobserver and intraobserver reliability of computed tomography (CT)-based 3-dimensional (3D) preoperative planning for primary TKA. METHODS: Twenty knees (10 with osteoarthritis and 10 with rheumatoid arthritis) were studied independently by 6 orthopedic surgeons using a CT-based 3D planning system. The measurements were made twice at more than 3-week intervals without any knowledge of their own previous measurements or those of the others...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29351933/vanadium-allergy-following-total-knee-arthroplasty
#2
Fidel Peat, Ross Coomber, Adnan Rana, Alastair Vince
Allergic reactions to metals following joint arthroplasty represent a rare and poorly understood phenomenon. Much is still unknown regarding the natural history of this complication, and how it can best be prevented and managed. We present a case of a 68-year-old woman who underwent a left total knee arthroplasty for treatment of osteoarthritis. After an initial uneventful postoperative course, she developed a troublesome erythematous rash both around the incision site and over her trunk. Blood testing revealed no evidence of infection and clinically her prosthesis was functioning well...
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29351749/meta-analysis-of-serum-c-reactive-protein-and-cartilage-oligomeric-matrix-protein-levels-as-biomarkers-for-clinical-knee-osteoarthritis
#3
Junfeng Zhang
BACKGROUND: The roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP, COMP, and the incidence/progression of KOA. METHODS: A systematic search was conducted on PubMed and Embase until September, 2016 for all the relevant studies. The pooled mean difference (MD) with its 95% confidence interval (95% CI) based on fixed effects model or random effects model was calculated to assess the potential role of CRP and COMP in the incidence or progression of KOA...
January 19, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29351654/what-is-the-role-of-imaging-in-the-clinical-diagnosis-of-osteoarthritis-and-disease-management
#4
Xia Wang, Win Min Oo, James M Linklater
While OA is predominantly diagnosed on the basis of clinical criteria, imaging may aid with differential diagnosis in clinically suspected cases. While plain radiographs are traditionally the first choice of imaging modality, MRI and US also have a valuable role in assessing multiple pathologic features of OA, although each has particular advantages and disadvantages. Although modern imaging modalities provide the capability to detect a wide range of osseous and soft tissue (cartilage, menisci, ligaments, synovitis, effusion) OA-related structural damage, this extra information has not yet favourably influenced the clinical decision-making and management process...
January 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29351562/clinical-and-ultrasonographic-features-associated-to-response-to-intraarticular-corticosteroid-injection-a-one-year-follow-up-prospective-cohort-study-in-knee-osteoarthritis-patient-with-joint-effusion
#5
Joan Calvet, Cristóbal Orellana, Carlos Galisteo, María García-Manrique, Noemí Navarro, Assumpta Caixàs, Marta Larrosa, Jordi Gratacós
OBJECTIVES: Intraarticular injection is used for pain relief in knee osteoarthritis (OA), but there is not a well defined profile of patient who could get more benefit from it. The purpose of this study was to evaluate the frequency of pain relief at one year after corticosteroids intraarticular injection and to identify clinical factors associated to response in patients with knee osteoarthritis with joint effusion. METHODS: One-year prospective cohort study of patients with knee OA with joint effusion confirmed by ultrasound...
2018: PloS One
https://www.readbyqxmd.com/read/29350331/motion-deficit-in-nodal-interphalangeal-joint-osteoarthritis-by-digital-goniometer-in-housewives
#6
L Ventura-Ríos, M Hayes-Salinas, D Ferrusquia-Toriz, R I Cariño-Escobar, E Cruz-Arenas, J Gutiérrez-Martínez, L González-Ramírez, C Hernández-Díaz
Range of motion (ROM) measured objectively in nodal hand osteoarthritis (NHOA) is missing. Evaluation of collateral ligaments by ultrasound (US) is unknown in NHOA also. To compare ROM in interphalangeal joints in housewives with nodal OA, with a control group by a digital system using angle to voltage (Multielgon). The second objective was to assess correlation between collateral radial and ulnar ligaments thickness and ROM. For this cross-sectional observational study, we assessed 60 hands with symptomatic NHOA and 30 hands of healthy housewives matched for age...
January 19, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29349935/pitfalls-in-the-measurement-of-muscle-mass-a-need-for-a-reference-standard
#7
Fanny Buckinx, Francesco Landi, Matteo Cesari, Roger A Fielding, Marjolein Visser, Klaus Engelke, Stefania Maggi, Elaine Dennison, Nasser M Al-Daghri, Sophie Allepaerts, Jurgen Bauer, Ivan Bautmans, Maria Luisa Brandi, Olivier Bruyère, Tommy Cederholm, Francesca Cerreta, Antonio Cherubini, Cyrus Cooper, Alphonso Cruz-Jentoft, Eugene McCloskey, Bess Dawson-Hughes, Jean-Marc Kaufman, Andrea Laslop, Jean Petermans, Jean-Yves Reginster, René Rizzoli, Sian Robinson, Yves Rolland, Ricardo Rueda, Bruno Vellas, John A Kanis
BACKGROUND: All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard. METHODS: Literature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia...
January 19, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29348998/meniscal-repair-with-fibrin-clot-augmentation
#8
Jorge Chahla, Nicholas I Kennedy, Andrew G Geeslin, Gilbert Moatshe, Mark E Cinque, Nicholas N DePhillipo, Robert F LaPrade
Meniscal injuries and meniscal loss are associated with changes in knee kinematics and loading, ultimately leading to poor functional outcomes and increased risk of progression to osteoarthritis. Biomechanical studies have shown restored knee function, and clinical studies have reported improved outcomes and decreased risk of osteoarthritis after meniscal repair. This has led orthopaedic surgeons to try and save the meniscus by repair whenever possible, as shown by increasing incidence of meniscal repair surgeries...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29346158/biomechanical-response-to-osteoarthritis-pain-treatment-may-impair-long-term-efficacy
#9
Katherine A Boyer
Pain has an important physiologic role and acts with and/or stimulates motor system adaptations to protect tissue from threats of damage. While clinically beneficial, removing the protective pain response may have negative consequence in osteoarthritis, a mechanically-mediated disease. We hypothesize motor system adaptations to joint pain and its treatment may impact osteoarthritis progression thereby limiting efficacy of pain therapies.
January 15, 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29345504/development-of-the-hoosglobal-to-assess-patient-reported-outcomes-in-patients-undergoing-hip-preservation-procedures
#10
Cale A Jacobs, Michael R Peabody, Stephen T Duncan, Ryan D Muchow, Ryan M Nunley, John C Clohisy, Paul E Beaule, Young Jo Kim, Michael B Millis, David A Podeszwa, Perry L Schoenecker, Rafael J Sierra, Ernest L Sink, Daniel J Sucato, Robert T Trousdale, Ira Zaltz
BACKGROUND: The creation of a single patient-reported outcome (PRO) platform validated across hip preservation, osteoarthritis (OA), and total hip arthroplasty (THA) populations may reduce barriers and streamline the routine collection of PROs in clinical practice. As such, the purpose of this study was to determine if augmenting the Hip disability and Osteoarthritis Outcome Score-Joint Replacement (HOOS, JR) with additional HOOS questions would result in a PRO platform that could be used across a wider spectrum of hip patient populations...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29343282/investigation-of-perioperative-safety-and-clinical-results-of-one-stage-bilateral-total-knee-arthroplasty-in-selected-low-risk-patients
#11
Hirotaka Mutsuzaki, Arata Watanabe, Tetsuya Komatsuzaki, Tomonori Kinugasa, Kotaro Ikeda
BACKGROUND: An increased perioperative complication rate has been a concern with one-stage bilateral total knee arthroplasty (TKA). The purpose of this study was to retrospectively investigate the perioperative safety and clinical results of one-stage bilateral TKA in selected low-risk patients. METHODS: Sixty-seven patients who received one-stage bilateral TKAs for osteoarthritis who were American Society of Anesthesiology (ASA) class 1 or 2 were included in this study...
January 17, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29343266/identification-of-pain-categories-associated-with-change-in-pain-in-patients-receiving-placebo-data-from-two-phase-3-randomized-clinical-trials-in-symptomatic-knee-osteoarthritis
#12
Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A Karsdal, Marc C Hochberg
BACKGROUND: Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial change in pain in patients receiving placebo, and more data describing clinical characteristics and pain categories particularly associated with this phenomenon is needed. The purpose of this post-hoc analysis was to investigate clinical characteristics and pain categories and their association with radiographic progression and placebo pain reduction (PPR) in OA patients as measured the Western Ontario and McMasters Arthritis (WOMAC)...
January 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29343182/fibronectin-enhances-cartilage-repair-by-activating-progenitor-cells-through-integrin-%C3%A9-5%C3%AE-1-receptor
#13
Tianqi Tao, Yang Li, Chang Gui, Yong Ma, Yingbin Ge, Hanhao Dai, Kaibin Zhang, Jing Du, Yang Guo, Yiqiu Jiang, Jianchao Gui
This study aimed to determine the effect of fibronectin (FN) on cartilage regeneration through the activation of chondrogenic progenitor cells (CPCs). Cells were isolated from the knee cartilage of mice and cultured in the presence of various concentrations of FN. Proliferation, migration and chondrogenic differentiation assays were performed in vitro. In some experiments, CPCs were pre-incubated with anti-integrin ɑ5β1 antibody for 60 min prior to FN treatment to block the integrin ɑ5β1 receptor. Soluble FN was mixed with Pluronic F-127 and injected into the joint cavity in an early-stage osteoarthritis (OA) model...
January 18, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29340746/similar-clinical-outcomes-following-collagen-or-polyurethane-meniscal-scaffold-implantation-a-systematic-review
#14
REVIEW
Darby A Houck, Matthew J Kraeutler, John W Belk, Eric C McCarty, Jonathan T Bravman
PURPOSE: The purpose of this systematic review is to evaluate the current literature in an effort to assess specific clinical outcomes following meniscal scaffold implantation using the two available scaffolds: Collagen Meniscal Implant (CMI) and the Actifit polyurethane meniscal scaffold. METHODS: A systematic review was performed by searching PubMed, Embase, and Cochrane Library to find studies evaluating clinical outcomes of patients undergoing meniscal scaffold implantation...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29338705/frailty-as-a-predictor-of-hospital-length-of-stay-after-elective-total-joint-replacements-in-elderly-patients
#15
Han Ting Wang, Josée Fafard, Stéphane Ahern, Pascal-André Vendittoli, Paul Hebert
BACKGROUND: Total joint replacement procedures are increasing in number because of population aging and osteoarthritis development. Defined as a lack of physiological reserves and the inability to adequately respond to external stressors, frailty may be more common than expected in older patients with degenerative arthritis awaiting total joint replacements. The aim of the present study was to assess associations between frailty and adverse outcomes, frailty prevalence among elderly patients awaiting elective TJR, and agreement between 2 frailty screening instruments...
January 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29335849/differential-expression-of-adipokines-in-knee-osteoarthritis-patients-with-and-without-metabolic-syndrome
#16
Ning Dong, Yu-Hang Gao, Bo Liu, Cheng-Wu Zhao, Chen Yang, Shu-Qiang Li, Jian-Guo Liu, Xin Qi
PURPOSE: The purpose of this study was to compare adipokines levels in plasma and synovial fluid (SF) between knee osteoarthritis (OA) patients with and without metabolic syndrome (MetS), and to evaluate the associations between adipokines levels and clinical severity of knee osteoarthritis. METHODS: Eighty female patients with knee osteoarthritis were enrolled in the study. These patients were divided into two groups: patients with and without MetS. Clinical severity was evaluated according to visual analogue scale (VAS) pain scores and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores...
January 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29334782/outcomes-of-bilateral-vs-unilateral-ankle-arthrodesis
#17
Yuji Maenohara, Akira Taniguchi, Kiyonori Tomiwa, Daisuke Tsuboyama, Hiroaki Kurokawa, Tsukasa Kumai, Sakae Tanaka, Yasuhito Tanaka
BACKGROUND: While ankle arthrodesis is a common treatment for severe ankle osteoarthritis, performing bilateral ankle arthrodesis is controversial because of associated problems, such as severe gait abnormality and bilateral loss of talocrural joint motion. Furthermore, few reports exist regarding the detailed outcomes of bilateral ankle arthrodesis. Therefore, we aimed to compare the outcomes of bilateral ankle arthrodesis with those of unilateral ankle arthrodesis, using both subjective and objective assessments...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29332754/conservative-management-of-thumb-carpometacarpal-osteoarthritis-an-italian-survey-of-current-clinical-practice
#18
Jorge Hugo Villafañe, Kristin Valdes, Virginia O'Brien, Monica Seves, Raquel Cantero-Téllez, Pedro Berjano
OBJECTIVE: The purpose of this study was to elucidate expert opinion on the conservative treatment of thumb carpometacarpal (CMC) joint osteoarthritis (OA). METHODS: A 21-item survey to determine the practice patterns of Italian hand therapists who treat arthritis of the CMC joint was developed and distributed through a professional online survey service to assure confidentiality and anonymity. RESULTS: Of the respondents, 80.8% were physical therapists; the remaining 19...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332174/a-friend-in-knee-ccn3-may-inhibit-osteoarthritis-progression
#19
Alex Peidl
Osteoarthritis (OA) is a major clinical problem among the ageing population, yet no disease-modifying treatments currently exist. This issue arises, in part, due to the complex processes occurring in the microenvironment of articular cartilage that lead to osteoarthritic changes. Gaining a better understanding of these processes is crucial in developing a viable therapy for OA. A recent report in Journal of Bone Mineral Metabolism by Janune et al. (J Bone Miner Metab 35:582-597, 2016) suggests a novel role for CCN3 in maintaining the differentiated phenotype of articular cartilage...
January 13, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29331994/acl-and-meniscal-injuries-increase-the-risk-of-primary-total-knee-replacement-for-osteoarthritis-a-matched-case-control-study-using-the-clinical-practice-research-datalink-cprd
#20
Tanvir Khan, Abtin Alvand, Daniel Prieto-Alhambra, David J Culliford, Andrew Judge, William F Jackson, Brigitte E Scammell, Nigel K Arden, Andrew James Price
OBJECTIVES: The aim of this study was to investigate whether ACL injury (ACLi) or meniscal injury increases the risk of end-stage osteoarthritis (OA) resulting in total knee replacement (TKR). METHODS: A matched case-control study of all TKRs performed in the UK between January 1990 and July 2011 and recorded in the Clinical Practice Research Datalink (CPRD) was undertaken. The CPRD contains longitudinal data on approximately 3.6 million patients. Two controls were selected for each case of TKR, matched on age, sex and general practitioner location as a proxy for socioeconomic status...
January 13, 2018: British Journal of Sports Medicine
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