Shan Zeng, Adrian M Seifert, Jennifer Q Zhang, Teresa S Kim, Timothy G Bowler, Michael J Cavnar, Benjamin D Medina, Gerardo A Vitiello, Ferdinand Rossi, Jennifer K Loo, Nesteene J Param, Ronald P DeMatteo
Gastrointestinal stromal tumor (GIST) is the most common sarcoma, often resulting from a KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutation. The lineage transcription factor ETV1 is expressed similarly in GISTs regardless of malignant potential. Although the related transcription factor ETV4 has been associated with metastasis and tumor progression in other cancers, its role in GIST is unknown. In this study, we found that ETV4 levels were high in a subset of human GISTs and correlated with high mitotic rate...
December 26, 2017: Oncotarget