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https://www.readbyqxmd.com/read/28344376/verification-measurements-of-the-irmm-1027-and-the-iaea-large-sized-dried-lsd-spikes
#1
R Jakopič, Y Aregbe, S Richter, E Zuleger, S Mialle, S D Balsley, U Repinc, J Hiess
In the frame of the accountancy measurements of the fissile materials, reliable determinations of the plutonium and uranium content in spent nuclear fuel are required to comply with international safeguards agreements. Large-sized dried (LSD) spikes of enriched (235)U and (239)Pu for isotope dilution mass spectrometry (IDMS) analysis are routinely applied in reprocessing plants for this purpose. A correct characterisation of these elements is a pre-requirement for achieving high accuracy in IDMS analyses. This paper will present the results of external verification measurements of such LSD spikes performed by the European Commission and the International Atomic Energy Agency...
2017: Journal of Radioanalytical and Nuclear Chemistry
https://www.readbyqxmd.com/read/28342178/return-of-the-lysergamides-part-iii-analytical-characterization-of-n-6-ethyl-6-norlysergic-acid-diethylamide-eth-lad-and-1-propionyl-eth-lad-1p-eth-lad
#2
Simon D Brandt, Pierce V Kavanagh, Folker Westphal, Simon P Elliott, Jason Wallach, Alexander Stratford, David E Nichols, Adam L Halberstadt
The psychoactive properties of lysergic acid diethylamide (LSD) have fascinated scientists across disciplines and the exploration of other analogs and derivatives has been motivated by deepening the understanding of ligand-receptor interactions at the molecular level as well as by the search for new therapeutics. Several LSD congeners have appeared on the new psychoactive substances (NPS) market in the form of blotters or powders. Examples include 1-propionyl-LSD (1P-LSD), AL-LAD and LSZ. The absence of analytical data for novel compounds is a frequent challenge encountered in clinical and toxicological investigations...
March 24, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28339841/nutritive-value-and-the-maximum-inclusion-level-of-pennycress-meal-for-broiler-chickens
#3
R A Alhotan, R L Wang, R A Holser, G M Pesti
Two experiments were conducted to evaluate the nutritive value and maximum safe level (MSL) of pennycress meal (PM) for broiler chicks. In experiment 1, a total of 480 chicks was fed either mash or crumbled diets containing zero, 5, 10, or 15% PM for 18 d (8 diets; 6 replications per diet). In experiment 2, a total of 660 chicks was fed mash diets containing zero, 3, 6, 9, 12, or 15% of either PM or canola meal (CM; a comparative reference) for 14 d (11 diets; 6 replications per diet). Analytical results show that PM is a good source of protein (∼31% CP) and it is very comparable to CM (∼36% CP)...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28338860/calculation-of-skin-dose-due-to-beta-contamination-using-the-new-quantity-of-the-icrp-116-the-local-skin-dose
#4
L Bourgois, S Ménard, N Comte
Values of the new protection quantity 'Local Skin Dose' LSD, introduced by the International Commission on Radiological Protection (ICRP) Publication 116, were calculated for 134 β- or β+ emitting radionuclides, using the Monte Carlo code MCNP6. Two types of source geometry are considered: a point source and disc-type surface contamination (the source is placed in contact with the skin). This new protection quantity is compared with the operational quantity H'(0.07,0°), leading us to conclude that, in accordance with the rules of the ICRP, the operational quantity over-estimates the protection quantity to a reasonable extent, except in very rare cases for very low average beta energies...
March 1, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28334745/disease-correction-by-aav-mediated-gene-therapy-in-a-new-mouse-model-of-mucopolysaccharidosis-type-iiid
#5
Carles Roca, Sandra Motas, Sara Marcó, Albert Ribera, Víctor Sánchez, Xavier Sánchez, Joan Bertolin, Xavier León, Jennifer Pérez, Miguel Garcia, Pilar Villacampa, Jesús Ruberte, Anna Pujol, Virginia Haurigot, Fatima Bosch
Gene therapy is a promising therapeutic alternative for Lysosomal Storage Disorders (LSD), as it is not necessary to correct the genetic defect in all cells of an organ to achieve therapeutically significant levels of enzyme in body fluids, from which non-transduced cells can uptake the protein correcting their enzymatic deficiency. Animal models are instrumental in the development of new treatments for LSD. Here we report the generation of the first mouse model of the LSD Muccopolysaccharidosis Type IIID (MPSIIID), also known as Sanfilippo syndrome type D...
February 17, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28329723/analysis-of-synthetic-phenethylamine-street-drugs-using-direct-sample-analysis-coupled-to-accurate-mass-time-of-flight-mass-spectrometry
#6
Maura K McGonigal, Joshua A Wilhide, Philip B Smith, Noelle M Elliott, Frank L Dorman
Serious health complications and fatal overdoses have brought phenethylamine, otherwise known as 2C, drug abuse to the public's attention. These compounds are 2C-X series analogs of mescaline. The name "2C" results from the two carbons in the ethyl chain. The substituents on these emerging drugs are constantly changed in order to avoid listing as controlled substances. These synthetic drugs are marketed as having affects similar to LSD and MDMA and are typically consumed sublingually via blotter paper. Twenty-six commercially available standards were analyzed using a direct sample analysis technique coupled to accurate mass time of flight mass spectrometry...
March 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28316947/analysis-of-the-mechanical-behavior-and-surface-rugosity-of-different-dental-die-materials
#7
Ciro T Niekawa, Simone Kreve, Gisseli Bertozzi A'vila, Gilmar Gil Godoy, J R Eduardo Vieira da Silva, Sergio Candido Dias
AIM: This work evaluated the mechanical and surface behavior of different die materials. The studied materials are polyurethane resin Exakto-Form (Bredent), Gypsum type IV, Fuji Rock EP (Gc), and Durone (Dentsply). MATERIALS AND METHODS: Two metallic matrices molded in polyvinyl siloxane provided 30 cylindrical test specimens for the diametral compression test and 30 hemispherical test specimens for the surface rugosity test. The cylindrical test specimens were submitted to tests of diametral compression strength using a DL2000 universal assay machine, with a load cell of 2000 Kgf and constant speed of 1 mm/min connected to the software...
January 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28316167/-influences-of-high-voltage-electrical-burns-on-microcirculation-perfusion-on-serosal-surface-of-small-intestine-of-rats-and-the-interventional-effects-of-pentoxifylline
#8
Q F Zhang, S J Xu, L M Liang, J K Feng, Y F Xu, L L Tu
Objective: To investigate influences of high-voltage electrical burns on microcirculation perfusion on serosal surface of small intestine of rats and the interventional effects of pentoxifylline (PTX). Methods: Totally 180 SD rats were divided into sham injury group, simple electrical burn group, and treatment group according to the random number table, with 60 rats in each group. The electrical current was applied to the outside proximal part of left forelimb of rats and exited from the outside proximal part of right hind limb of rats...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28304074/relative-frequency-and-estimated-minimal-frequency-of-lysosomal-storage-diseases-in-brazil-report-from-a-reference-laboratory
#9
Roberto Giugliani, Andressa Federhen, Kristiane Michelin-Tirelli, Mariluce Riegel, Maira Burin
Lysosomal storage diseases (LSDs) comprise a heterogeneous group of more than 50 genetic conditions of inborn errors of metabolism (IEM) caused by a defect in lysosomal function. Although there are screening tests for some of these conditions, diagnosis usually depends on specific enzyme assays, which are only available in a few laboratories around the world. A pioneer facility for the diagnosis of IEM and LSDs was established in the South of Brazil in 1982 and has served as a reference service since then. Over the past 34 years, samples from 72,797 patients were referred for investigation of IEM, and 3,211 were confirmed as having an LSD (4...
March 16, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28302345/newborn-screening-for-six-lysosomal-storage-disorders-in-a-cohort-of-mexican-patients-three-year-findings-from-a-screening-program-in-a-closed-mexican-health-system
#10
Juana Inés Navarrete-Martínez, Ana Elena Limón-Rojas, Maria de Jesús Gaytán-García, Jesús Reyna-Figueroa, Guillermo Wakida-Kusunoki, Ma Del Rocío Delgado-Calvillo, Consuelo Cantú-Reyna, Héctor Cruz-Camino, David Eduardo Cervantes-Barragán
OBJECTIVE: To evaluate the results of a lysosomal newborn screening (NBS) program in a cohort of 20,018 Mexican patients over the course of 3years in a closed Mexican Health System (Petróleos Mexicanos [PEMEX] Health Services). STUDY DESIGN: Using dried blood spots (DBS), we performed a multiplex tandem mass spectrometry enzymatic assay for six lysosomal storage disorders (LSDs) including Pompe disease, Fabry disease, Gaucher disease, mucopolysaccharidosis type I (MPS-I), Niemann-Pick type A/B, and Krabbe disease...
March 9, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28298989/effects-of-different-intra-canal-medicaments-on-the-push-out-bond-strength-of-endodontic-sealers
#11
Sahar Shakouie, Shahriar Shahi, Mohammad Samiei, Amin-Salem Milani, Mohammad-Frough Reyhani, Sara Paksefat, Mahsa Eskandarinekhad, Negin Ghasemi
BACKGROUND: One of the essential properties of the root canal sealers is the adhesion to root canal dentin and their higher bond strength decreases the microleakage. The aim of the present study was to compare the effect of Different Intracanal medicaments on the push out bond strength of AH26 and MTA Fillapex sealers. MATERIAL AND METHODS: A total of 104 one-rooted extracted human teeth were divided into 4 (n=26) experimental groups. After the cleaning and shaping, the root canals were filled with Ca(OH)2, triantibiotic paste (TAP), Metapex or 2% chlorhexidine gel for two weeks...
March 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28287414/an-optically-pumped-magnetometer-working-in-the-light-shift-dispersed-mz-mode
#12
Volkmar Schultze, Bastian Schillig, Rob IJsselsteijn, Theo Scholtes, Stefan Woetzel, Ronny Stolz
We present an optically pumped magnetometer working in a new operational mode-the light-shift dispersed Mz (LSD-Mz) mode. It is realized combining various features; (1) high power off-resonant optical pumping; (2) Mz configuration, where pumping light and magnetic field of interest are oriented parallel to each other; (3) use of small alkali metal vapor cells of identical properties in integrated array structures, where two such cells are pumped by circularly polarized light of opposite helicity; and (4) subtraction of the Mz signals of these two cells...
March 10, 2017: Sensors
https://www.readbyqxmd.com/read/28284627/lumpy-skin-disease-outbreaks-in-greece-during-2015-16-implementation-of-emergency-immunization-and-genetic-differentiation-between-field-isolates-and-vaccine-virus-strains
#13
Eirini I Agianniotaki, Konstantia E Tasioudi, Serafeim C Chaintoutis, Peristera Iliadou, Olga Mangana-Vougiouka, Aikaterini Kirtzalidou, Thomas Alexandropoulos, Achilleas Sachpatzidis, Evangelia Plevraki, Chrysostomos I Dovas, Eleni Chondrokouki
The objective of this study is to present epizootiological data from the lumpy skin disease (LSD) outbreaks in Greece during 2015-16, following the implementation of emergency vaccination and total stamping-out, along with laboratory data regarding the genetic differentiation between field isolates and live attenuated vaccine virus strains. Descriptive geographical chronology analysis was conducted to present the progressive shift of the outbreaks westwards, and at the same time, the absence of further outbreaks in previously affected regional units where high vaccination coverage was achieved...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28282939/oral-health-status-of-patients-with-lysosomal-storage-diseases-in-poland
#14
Damian Drążewski, Małgorzata Grzymisławska, Katarzyna Korybalska, Natasza Czepulis, Marian Grzymisławski, Janusz Witowski, Anna Surdacka
Patients with lysosomal storage diseases (LSDs) suffer from physical and mental disabilities, which together with poor access to professional care may lead to impaired oral health. This cross-sectional case-control study characterized the status of oral health in patients with LSDs in Poland. Thirty-six children and young adults with various forms of LSDs were examined. The data were compared with those from age- and sex-matched healthy controls. Exemplary cases were presented to highlight typical problems in oral care associated with LSDs...
March 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28282557/the-effect-of-combined-photobiomodulation-and-metformin-on-open-skin-wound-healing-in-a-non-genetic-model-of-type-ii-diabetes
#15
Mohammadali Asghari, Ali Kanonisabet, Mandanad Safakhah, Zahra Azimzadeh, Ataroalsadat Mostafavinia, Soudabeh Taheri, Abdollah Amini, Seyed Kamran Ghorishi, Reza JalaliFiroozkohi, Sahar Bayat, Mohammad Bayat
This study intended to examine the combined influences of photobiomodulation (PBM) and metformin on the microbial flora and biomechanical parameters of wounds in a non-genetic model of type II diabetes mellitus (TII DM). We induced a non-genetic model of TII DM in 20 rats by feeding them a 10% fructose solution for 2weeks followed by an injection of streptozotocin (STZ, 40mg/kg). After 21days from the injection of STZ, we induced one full-thickness skin wound in each of the diabetic rats. We randomly divided the rats into four groups: i) placebo; ii) pulsed wave laser (890nm, 80Hz, 0...
March 6, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28268791/the-letter-and-shape-drawing-lsd-test-an-efficient-and-systematised-approach-to-testing-of-visuospatial-function
#16
Michael Tenorio, Olugbenga A Williams, Maeve Leonard, Debbie White, Frank McKenna, Colum P Dunne, David Meagher, Chris Exton
The automation and systemisation of the next generation of cognitive assessment approaches have the potential to change how clinicians assess and interact with patients. This may be especially pertinent in the case of delirium, as current methods often rely on the subjective opinion of clinicians and specialists, with potential for the condition to be overlooked or misdiagnosed. Currently, one of the most commonly used tests, is the clock-drawing test, which has relatively wide appeal as a cognitive screening instrument due to its clinical utility and psychometric properties...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267586/maternal-carbamazepine-alters-fetal-neuroendocrine-cytokines-axis
#17
R G Ahmed
This study detected the effects of maternal carbamazepine (CBZ) on the fetal neuroendocrine-cytokines axis. 25 or 50mg/kg of CBZ was intraperitoneally administrated to pregnant rats from gestation day (GD) 1 to 20. In dams and their fetuses, there was an elevation in the values of serum thyrotropin (TSH) which was accompanied by a decrease in the values of serum thyroxine (T4) and triiodothyronine (T3) at GD 20 due to both maternal administrations of CBZ compared to the control group. Also, both administrations had undesirable impacts on the maternal body weight gain, fetal body weight, survival of dams and fetuses, food consumption, and litter weight as compared to the corresponding control group...
March 3, 2017: Toxicology
https://www.readbyqxmd.com/read/28266544/misrouting-of-v-atpase-subunit-v0a1-dysregulates-lysosomal-acidification-in-a-neurodegenerative-lysosomal-storage-disease-model
#18
Maria B Bagh, Shiyong Peng, Goutam Chandra, Zhongjian Zhang, Satya P Singh, Nagarajan Pattabiraman, Aiyi Liu, Anil B Mukherjee
Defective lysosomal acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurodegenerative diseases like Alzheimer's and Parkinson's. Despite its fundamental importance, the mechanism(s) underlying this defect remains unclear. The v-ATPase, a multisubunit protein complex composed of cytosolic V1-sector and lysosomal membrane-anchored V0-sector, regulates lysosomal acidification. Mutations in the CLN1 gene, encoding PPT1, cause a devastating neurodegenerative LSD, INCL...
March 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28260358/-relationship-between-visual-field-index-and-visual-field-morphological-stages-of-glaucoma-and-their-diagnostic-value
#19
X R Hou, J Y Qin, Z Q Ren
Objective: To investigate the rationality of visual field morphological stages of glaucoma, its relationship with visual field index and their diagnostic value. Methods: Retrospective series case study. Two hundred and seventy-four glaucoma patients and 100 normal control received visual field examination by Humphrey perimeter using standard automatic perimetry (SAP) program from March 2014 to September 2014. Glaucoma patients were graded into four stages according to characteristic morphological damage of visual field, distribution of mean defect (MD) and visual field index (VFI) of each stage were plotted and receiver operation characteristic curve (ROC) was used to explore its correlation with MD and VFI...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28249783/diet-driven-microbiota-dysbiosis-is-associated-with-vagal-remodeling-and-obesity
#20
Tanusree Sen, Carolina R Cawthon, Benjamin Thomas Ihde, Andras Hajnal, Patricia M DiLorenzo, Claire B de La Serre, Krzysztof Czaja
Obesity is one of the major health issues in the United States. Consumption of diets rich in energy, notably from fats and sugars (high-fat/high-sugar diet: HF/HSD) is linked to the development of obesity and a popular dietary approach for weight loss is to reduce fat intake. Obesity research traditionally uses low and high fat diets and there has been limited investigation of the potential detrimental effects of a low-fat/high-sugar diet (LF/HSD) on body fat accumulation and health. Therefore, in the present study, we investigated the effects of HF/HSD and LF/HSD on microbiota composition, gut inflammation, gut-brain vagal communication and body fat accumulation...
February 26, 2017: Physiology & Behavior
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