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https://www.readbyqxmd.com/read/29627514/combined-effects-of-photobiomodulation-and-alendronate-on-viability-of-osteoporotic-bone-marrow-derived-mesenchymal-stem-cells
#1
Somaye Fallahnezhad, Abdollah Amini, Behnam Hajihossainlou, Sufan Chien, Sara Dadras, Fatemehalsadat Rezaei, Mohammad Bayat
Osteoporotic bone marrow mesenchymal stem cells (BMMSCs) are involved in the pathogenesis of osteoporosis (OP). Photobiomodulation (PBM) has positive effects on healthy BMMSCs. The goal of current experiment was to evaluate the combined influence of photobiomodulation PBM and alendronate (ALN) incubation on ovariectomized induced osteoporosis(OVX)- BMMSC viability in vitro. 15 female adult Wistar rats were distributed into the 2 groups: (1) 3 healthy (sham)control rats, (2) 12 OVX- rats. All OVX rats underwent ovariectomy...
March 22, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29617830/detecting-signatures-of-positive-selection-along-defined-branches-of-a-population-tree-using-lsd
#2
Pablo Librado, Ludovic Orlando
Identifying the genomic basis underlying local adaptation is paramount to evolutionary biology, and bears many applications in the fields of conservation biology, crop and animal breeding, as well as personalized medicine. While many approaches have been developed to detect signatures of positive selection within single populations and population pairs, the increasing wealth of high-throughput sequencing data requires improved methods capable of handling multiple, and ideally large number of, populations in a single analysis...
March 29, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29616052/the-role-of-programmed-cell-death-regulator-lsd1-in-nematode-induced-syncytium-formation
#3
Mateusz Matuszkiewicz, Miroslaw Sobczak, Javier Cabrera, Carolina Escobar, Stanislaw Karpiński, Marcin Filipecki
Cyst-forming plant-parasitic nematodes are common pests of many crops. They inject secretions into host cells to induce the developmental and metabolic reprogramming that leads to the formation of a syncytium, which is the sole food source for growing nematodes. As in other host-parasite models, avirulence leads to rapid and local programmed cell death (PCD) known as the hypersensitive response (HR), whereas in the case of virulence, PCD is still observed but is limited to only some cells. Several regulators of PCD were analyzed to understand the role of PCD in compatible plant-nematode interactions...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29567512/the-effects-of-one-night-of-partial-sleep-deprivation-on-executive-functions-in-individuals-reporting-chronic-insomnia-and-good-sleepers
#4
Andrea Ballesio, Silvia Cerolini, Fabio Ferlazzo, Nicola Cellini, Caterina Lombardo
BACKGROUND AND OBJECTIVES: The aim of the present study was to investigate the effects of a partial sleep deprivation night on executive functions in participants reporting chronic insomnia and good sleepers using a Task Switching paradigm. METHODS: Sixteen participants reporting symptoms of chronic insomnia and sixteen good sleepers were tested after a night of habitual sleep and after a night of partial sleep deprivation (5 h of sleep allowed). The Switch Cost (SC) and the Backward Inhibition (BI) were computed as measures of switching attention and response inhibition, respectively...
February 15, 2018: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29560311/altered-network-hub-connectivity-after-acute-lsd-administration
#5
Felix Müller, Patrick C Dolder, André Schmidt, Matthias E Liechti, Stefan Borgwardt
LSD is an ambiguous substance, said to mimic psychosis and to improve mental health in people suffering from anxiety and depression. Little is known about the neuronal correlates of altered states of consciousness induced by this substance. Limited previous studies indicated profound changes in functional connectivity of resting state networks after the administration of LSD. The current investigation attempts to replicate and extend those findings in an independent sample. In a double-blind, randomized, cross-over study, 100 μg LSD and placebo were orally administered to 20 healthy participants...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29555857/role-of-the-5-ht-2a-receptor-in-self-and-other-initiated-social-interaction-in-lsd-induced-states-a-pharmacological-fmri-study
#6
Katrin H Preller, Leonhard Schilbach, Thomas Pokorny, Jan Flemming, Erich Seifritz, Franz X Vollenweider
Distortions of self-experience are critical symptoms of psychiatric disorders and have detrimental effects on social interactions. In light of the immense need for improved and targeted interventions for social impairments, it is important to better understand the neurochemical substrates of social interaction abilities. We therefore investigated the pharmacological and neural correlates of self- and other-initiated social interaction. In a double-blind, randomized, counterbalanced, cross-over study 24 healthy human participants (18 males and 6 females) received either 1) placebo+placebo 2) placebo+lysergic acid diethylamide (LSD) (100 μg p...
March 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29549713/synesthetic-hallucinations-induced-by-psychedelic-drugs-in-a-congenitally-blind-man
#7
Sara Dell'Erba, David J Brown, Michael J Proulx
This case report offers rare insights into crossmodal responses to psychedelic drug use in a congenitally blind (CB) individual as a form of synthetic synesthesia. BP's personal experience provides us with a unique report on the psychological and sensory alterations induced by hallucinogenic drugs, including an account of the absence of visual hallucinations, and a compelling look at the relationship between LSD induced synesthesia and crossmodal correspondences. The hallucinatory experiences reported by BP are of particular interest in light of the observation that rates of psychosis within the CB population are extremely low...
March 14, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29544984/secondary-caries-formation-with-a-two-species-biofilm-artificial-mouth
#8
Stefanie Amend, Roland Frankenberger, Susanne Lücker, Eugen Domann, Norbert Krämer
OBJECTIVES: The present study aimed to establish Lactobacillus casei in a completely automated Streptococcus mutans-based artificial mouth model and to investigate secondary caries inhibiting properties of glass ionomer cements / resin composite groups in vitro. METHODS: Sixty extracted, caries-free human third molars were used for preparation of standardized class-V-cavities. Specimens were restored with a resin-modified (Photac Fil; PF) as well as a conventional glass ionomer cement (Ketac Molar; KM) and one resin composite bonded with and without conduction of etch-and-rinse technique (Prime&Bond NT, Ceram X mono; C+ERT, C)...
March 12, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29540625/dietary-exposure-risk-assessment-of-flonicamid-and-its-effect-on-constituents-after-application-in-lonicerae-japonicae-flos
#9
Jiaxin Li, Yujie Wang, Jian Xue, Pengsi Wang, Shangmei Shi
To investigate the dietary exposure risk of flonicamid application on Lonicerae Japonicae Flos and the effect of flonicamid on constituents of Lonicerae Japonicae Flos, field experiments were conducted in Fengqiu, Henan province, and flonicamid residue in samples collected was detected by gas chromatography equipped with electron capture detector (GC-ECD). And chlorogenic acid and luteoloside were determined by HPLC. Dietary exposure risk assessment was conducted through comparing the estimated daily intake (EDI) which was calculated by using the consumed residual level along with the acceptable daily intake (ADI)...
March 14, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29526213/simultaneous-and-individual-quantitative-estimation-of-salmonella-shigella-and-listeria-monocytogenes-on-inoculated-roma-tomatoes-lycopersicon-esculentum-var-pyriforme-and-serrano-peppers-capsicum-annuum-using-an-mpn-technique
#10
E Cabrera-Díaz, L Martínez-Chávez, J Sánchez-Camarena, J A Muñiz-Flores, A Castillo, P Gutiérrez-González, S M Arvizu-Medrano, D G González-Aguilar, N E Martínez-Gonzáles
Simultaneous and individual enumeration of Salmonella, Shigella and Listeria monocytogenes was compared on inoculated Roma tomatoes and Serrano peppers using an Most Probable Number (MPN) technique. Samples consisting of tomatoes (4 units) or peppers (8 units) were individually inoculated with a cocktail of three strains of Salmonella, Shigella or L. monocytogenes, or by simultaneous inoculation of three strains of each pathogen, at low (1.2-1.7 log CFU/sample) and high (2.2-2.7 log CFU/sample) inocula. Samples were analyzed by an MPN technique using universal pre-enrichment (UP) broth at 35 °C for 24 ± 2 h...
August 2018: Food Microbiology
https://www.readbyqxmd.com/read/29514388/iroot-fm-exerts-an-antibacterial-effect-on-porphyromonas-endodontalis-and-improves-the-properties-of-stem-cells-from-the-apical-papilla
#11
J Bi, Y Liu, X M Liu, L M Jiang, X Chen
AIM: To investigate the antibacterial activity of a novel intracanal medicament, iRoot FM, against Porphyromonas endodontalis (P. endodontalis) and its effects on the proliferation and osteo-/odontogenic differentiation of stem cells from apical papilla (SCAP). METHODOLOGY: The agar diffusion test was used to compare the antimicrobial efficacy of iRoot FM with two traditional intracanal medicaments, calcium hydroxide [Ca(OH)2 ] and triple antibiotic paste (TAP)...
March 7, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29511490/chronic-intermittent-hypobaric-hypoxia-attenuates-monocrotaline-induced-pulmonary-arterial-hypertension-via-modulating-inflammation-and-suppressing-nf-%C3%AE%C2%BAb-p38-pathway
#12
Lei Gao, Jun Liu, Yongmei Hao, Zengren Zhao, Huilian Tan, Jie Zhang, Ning Meng, Qinghou Zheng, Zhen Wang, Yi Zhang
Objectives: Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the effect of chronic intermittent hypobaric hypoxia (CIHH) on pulmonary inflammation and remodeling in monocrotaline (MCT) induced PAH in rats. Materials and Methods: An in vivo model of PAH induced by MCT was employed...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29506311/the-beneficial-effects-of-trimetazidine-on-reperfusion-induced-arrhythmia-in-diabetic-rats
#13
Fatemeh Ramezani-Aliakbari, Mohammad Badavi, Mahin Dianat, Seyed Ali Mard, Akram Ahangarpour
Trimetazidine (TMZ), as an anti-ischemic drug, plays a critical role in protecting against cardiovascular complications induced by diabetes. This study was therefore aimed to evaluate the protective effects of TMZ on reperfusion-induced arrhythmias in the diabetic rats. Male Sprague-Dawley rats (250±20 g) were randomly assigned to four (n=8): control rats (C), alloxan induced diabetic rats (D), diabetic rats treated with TMZ (10 mg/kg, D+T10), diabetic rats treated with TMZ (30 mg/kg, D+T30). TMZ was treated orally once daily for 8 weeks...
March 5, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29505173/the-effectiveness-of-various-irrigation-protocols-on-organic-tissue-removal-from-simulated-internal-resorption-defects
#14
Ö I Ulusoy, I G Savur, T Alaçam, B Çelik
AIM: To evaluate the effectiveness of NaOCl, NaOCl-EDTA, and NaOCl+HEBP activated by ultrasonics and XP-endo Finisher on organic tissue removal from simulated internal root resorption cavities. METHODOLOGY: The root canals of 144 single-rooted teeth were instrumented. The teeth were split longitudinally and semicircular cavities were prepared in the canals on each half of the roots. Samples obtained from ground bovine muscle tissue were weighed and adapted into the semicircular cavities...
March 5, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29503202/overcoming-limitations-inherent-in-sulfamidase-to-improve-mucopolysaccharidosis-iiia-gene-therapy
#15
Yonghong Chen, Shujuan Zheng, Luis Tecedor, Beverly L Davidson
Sulfamidase (SGSH) deficiency causes mucopolysaccharidosis type IIIA (MPS IIIA), a lysosomal storage disease (LSD) that affects the CNS. In earlier work in LSD mice and dog models, we exploited the utility of adeno-associated viruses (AAVs) to transduce brain ventricular lining cells (ependyma) for secretion of lysosomal hydrolases into the cerebrospinal fluid (CSF), with subsequent distribution of enzyme throughout the brain resulting in improved cognition and extending lifespan. A critical feature of this approach is efficient secretion of the expressed enzyme from transduced cells, for delivery by CSF to nontransduced cells...
January 31, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29497949/pulmonary-functions-and-sleep-related-breathing-disorders-in-lipid-storage-disease
#16
Züleyha Bingöl, Hacer Durmuş Tekce, Gülseren Sağcan, Piraye Serdaroğlu, Esen Kıyan
PURPOSE: Pulmonary function abnormalities and sleep-related breathing disorders (SRBD) are frequent in subjects with several neuromuscular diseases but there is no data about lipid storage diseases (LSD). Therefore, we aimed to evaluate pulmonary functions and SRBD in adults with LSD. METHODS: Pulmonary functions (forced expiratory volume (FEV1 ), forced vital capacity (FVC), supine FVC, upright-supine FVC% change, maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), peak cough flow (PCF)), arterial blood gases, and polysomnographic data of all subjects were evaluated...
March 1, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29479887/niemann-pick-disease-type-c1-gene-expression-in-pbmcs-is-associated-with-interleukin-10-serum-concentration-a-case-control-study
#17
Fatemeh Zali, Maryam Teimouri, Parisa Shabani, Akram Vatannejad, Mahdi Najafi, Hossein Shateri, Mostafa Asadnia, Mahmood Doosti
BACKGROUND: Recent studies showed that atherosclerosis is a lysosomal storage disease (LSD) and Niemann-Pick disease type C1 (NPC1) is the most important protein of the lysosomal membrane that is involved in the removal of FC from lysosomes. Whereas several in vitro and in vivo studies have described the crosstalk between lysosomal cholesterol accumulation and increased inflammation, there is no study addressing the correlation between NPC1 gene expression and an anti-inflammatory cytokine, interleukin 10 (IL-10) serum concentration in atherosclerotic patients...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29478824/an-unexpected-player-in-gaucher-disease-the-multiple-roles-of-complement-in-disease-development
#18
REVIEW
Manoj K Pandey, Gregory A Grabowski, Jörg Köhl
The complement system is well appreciated for its role as an important effector of innate immunity that is activated by the classical, lectin or alternative pathway. C5a is one important mediator of the system that is generated in response to canonical and non-canonical C5 cleavage by circulating or cell-derived proteases. In addition to its function as a chemoattractant for neutrophils and other myeloid effectors, C5a and its sister molecule C3a have concerted roles in cell homeostasis and surveillance. Through activation of their cognate G protein coupled receptors, C3a and C5a regulate multiple intracellular pathways within the mitochondria and the lysosomal compartments that harbor multiple enzymes critical for protein, carbohydrate and lipid metabolism...
February 22, 2018: Seminars in Immunology
https://www.readbyqxmd.com/read/29476779/psychedelics-where-we-are-now-why-we-got-here-what-we-must-do
#19
REVIEW
Sean J Belouin, Jack E Henningfield
The purpose of this commentary is to provide an introduction to this special issue of Neuropharmacology with a historical perspective of psychedelic drug research, their use in psychiatric disorders, research-restricting regulatory controls, and their recent emergence as potential breakthrough therapies for several brain-related disorders. It begins with the discovery of lysergic acid diethylamide (LSD) and its promising development as a treatment for several types of mental illnesses during the 1940s. This was followed by its abuse and stigmatization in the 1960s that ultimately led to the placement of LSD and other psychedelic drugs into the most restrictively regulated drug schedule of the United States Controlled Substances Act (Schedule I) in 1970 and its international counterparts...
February 21, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29469525/-comparison-of-three-different-methods-for-isolating-rna-from-oncomelania-hupensis
#20
Xu Shu-Jun, Wang Kang, Zhang Min-Hong, Chen Wen-Jie, Guan Guo-Yu, Liu Man-Man, Xu Lei, Sun En-Tao
OBJECTIVE: To compare the effects of three kinds of Oncomelania hupensis RNA extraction methods, namely a modified SDS method, TRIzol reagent method, and CTAB method, so as to obtain an economical and efficient method for RNA extraction from O. hupensis . METHODS: The modified SDS method, TRIzol reagent method and CTAB method were applied to extract the RNA from O. hupensis . A nucleic acid protein analyzer was used to measure the concentration and purity of RNA...
May 22, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
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