G Acero, K Manoutcharian, V Vasilevko, M E Munguia, T Govezensky, G Coronas, A Luz-Madrigal, D H Cribbs, G Gevorkian
N-truncated and N-modified forms of amyloid beta (Abeta) peptide are found in diffused and dense core plaques in Alzheimer's disease (AD) and Down's syndrome patients as well as transgenic mouse models of AD. Although the pathological significance of these shortened forms Abeta is not completely understood, previous studies have demonstrated that these peptides are significantly more resistant to degradation, aggregate more rapidly in vitro and exhibit similar or, in some cases, increased toxicity in hippocampal neuronal cultures compared to the full length peptides...
August 18, 2009: Journal of Neuroimmunology