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https://www.readbyqxmd.com/read/29926900/breast-conserving-surgery-followed-by-whole-breast-irradiation-offers-survival-benefits-over-mastectomy-without-irradiation
#1
J de Boniface, J Frisell, L Bergkvist, Y Andersson
BACKGROUND: The prognostic equivalence between mastectomy and breast-conserving surgery (BCS) followed by radiotherapy was shown in pivotal trials conducted decades ago. Since then, detection and treatment of breast cancer have improved substantially and recent retrospective analyses point towards a survival benefit for less extensive breast surgery. Evidence for the association of such survival data with locoregional recurrence rates is largely lacking. METHODS: The Swedish Multicentre Cohort Study prospectively included clinically node-negative patients with breast cancer who had planned sentinel node biopsy between 2000 and 2004...
June 21, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29922596/comparison-of-local-recurrence-among-early-breast-cancer-patients-treated-with-electron-intraoperative-radiotherapy-vs-hypofractionated-photon-radiotherapy-an-observational-study
#2
Marina Guenzi, Elisabetta Bonzano, Renzo Corvò, Francesca Merolla, Alice Pastorino, Francesca Cavagnetto, Stefania Garelli, Carlo Alberto Cutolo, Daniele Friedman, Liliana Belgioia
Purpose: To evaluate local recurrence (LR) in women with early breast cancer (BC) who underwent intraoperative radiation therapy with electrons particles (IORT-E) or adjuvant hypofractionated external radiotherapy (HYPOFX). Materials and methods: We retrospectively analyzed 470 patients with early BC treated at our center from September 2009 to December 2012. 235 women were treated with breast-conserving surgery and immediate IORT-E (21 Gy/1 fraction) while 235 patients underwent wide excision followed by hypofractionated whole-breast irradiation...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29914426/effects-of-local-anesthetics-on-breast-cancer-cell-viability-and-migration
#3
Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P Dilger, Jun Lin
BACKGROUND: Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical studies have suggested that use of regional anesthesia leads to improved patient outcomes. Laboratory studies have reported that breast cancer cells are inhibited by some local anesthetics at millimolar concentration. Here, we present a comprehensive analysis of the effects of six common local anesthetics on two human breast cancer cell lines...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29910612/chitosan-gold-nanoparticles-induce-cell-death-in-hela-and-mcf-7-cells-through-reactive-oxygen-species-production
#4
Ana Carolina Martínez-Torres, Diana G Zarate-Triviño, Helen Yarimet Lorenzo-Anota, Andrea Ávila-Ávila, Carolina Rodríguez-Abrego, Cristina Rodríguez-Padilla
Background: Nanotechnology has gained important interest, especially in the development of new therapies; the application of gold nanoparticles (AuNPs) in the treatment and detection of diseases is a growing trend in this field. As cancer represents a serious health problem around the world, AuNPs are studied as potential drugs or drug carriers for anticancer agents. Recent studies show that AuNPs stabilized with chitosan (CH) possess interesting biological activities, including potential antitumor effects that could be selective to cancer cells...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29910501/severe-angioedema-of-laryngeal-inlet-in-a-woman-receiving-telmisartan-therapy-undergoing-breast-conservation-surgery
#5
Bikram Kishore Behera, Satyajeet Misra, Madhabananda Kar
No abstract text is available yet for this article.
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29903796/should-women-aged-70-74-be-invited-to-participate-in-screening-mammography-a-report-on-two-australian-community-juries
#6
Chris Degeling, Alexandra Barratt, Sanchia Aranda, Robin Bell, Jenny Doust, Nehmat Houssami, Jolyn Hersch, Ruben Sakowsky, Vikki Entwistle, Stacy M Carter
OBJECTIVE: To elicit informed views from Australian women aged 70-74 regarding the acceptability of ceasing to invite women their age to participate in government-funded mammography screening (BreastScreen). DESIGN: Two community juries held in 2017. SETTING: Greater Sydney, a metropolis of 4.5 million people in New South Wales, Australia. PARTICIPANTS: 34 women aged 70-74 with no personal history of breast cancer, recruited by random digit dialling and previously randomly recruited list-based samples...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29902386/hypofractionated-radiation-treatment-in-the-management-of-breast-cancer
#7
Apar Gupta, Nisha Ohri, Bruce G Haffty
The standard treatment for early-stage breast cancer is breast conservation therapy, consisting of breast conserving surgery followed by adjuvant radiation treatment (RT). Conventionally-fractionated whole breast irradiation (CF-WBI) has been the standard RT regimen, but recently shorter courses of hypofractionated whole breast irradiation (HF-WBI) have been advocated for patient convenience and reduction in healthcare costs and resources. Areas covered: This review covers the major randomized European and Canadian trials comparing HF-WBI to CF-WBI with long-term follow-up, as well as additional recently closed randomized trials that further seek to define the applicability of HF-WBI in clinical practice...
June 14, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29900127/omission-of-postoperative-radiotherapy-in-women-aged-65-years-or-older-with-tubular-carcinoma-of-the-breast-after-breast-conserving-surgery
#8
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Yong-Xiong Chen, Zhen-Yu He
Introduction: To investigate the temporal trends of postoperative radiotherapy (RT) administration and the effects of omitting postoperative RT on breast cancer-specific survival (BCSS) in women aged ≥65 years with tubular carcinoma (TC) of the breast who received breast-conserving surgery (BCS). Methods: We included women aged ≥ 65 years with non-metastatic TC of the breast who underwent BCS between 2000 and 2013 using the Surveillance, Epidemiology, and End Results database...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29891089/fully-automatic-and-robust-segmentation-of-the-clinical-target-volume-for-radiotherapy-of-breast-cancer-using-big-data-and-deep-learning
#9
Kuo Men, Tao Zhang, Xinyuan Chen, Bo Chen, Yu Tang, Shulian Wang, Yexiong Li, Jianrong Dai
PURPOSE: To train and evaluate a very deep dilated residual network (DD-ResNet) for fast and consistent auto-segmentation of the clinical target volume (CTV) for breast cancer (BC) radiotherapy with big data. METHODS: DD-ResNet was an end-to-end model enabling fast training and testing. We used big data comprising 800 patients who underwent breast-conserving therapy for evaluation. The CTV were validated by experienced radiation oncologists. We performed a fivefold cross-validation to test the performance of the model...
June 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29887731/the-payer-and-patient-cost-burden-of-open-breast-conserving-procedures-following-percutaneous-breast-biopsy
#10
Chloe C Kimball, Christine I Nichols, Joshua G Vose
Objectives: Percutaneous core-needle biopsy (PCNB) is the standard of care to biopsy and diagnose suspicious breast lesions. Dependent on histology, many patients require additional open procedures for definitive diagnosis and excision. This study estimated the payer and patient out-of-pocket (OOP) costs, and complication risk, among those requiring at least 1 open procedure following PCNB. Methods: This retrospective study used the Truven Commercial database (2009-2014)...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29881286/clinicopathologic-features-and-radiation-therapy-utilization-in-patients-with-male-breast-cancer-a-national-cancer-database-study
#11
REVIEW
Joshua Weir, Yan Daniel Zhao, Terence Herman, Özer Algan
Male breast cancer (MBC) accounts for approximately 1% of all breast cancers, limiting the data characterizing clinicopathologic features and treatment outcomes in patients with MBC. This paucity of data has led to most of our treatment guidance being extrapolated from patients with female breast cancer (FBC). From 1998 to 2012, data were captured using the National Cancer Database to identify patients with nonmetastatic MBC (n = 23 305) and FBC (n = 2 678 061). Tumor and clinicopathologic features were obtained and compared...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29880480/macrophages-promote-circulating-tumor-cell-mediated-local-recurrence-following-radiation-therapy-in-immunosuppressed-patients
#12
Marjan Rafat, Todd A Aguilera, Marta Vilalta, Laura L Bronsart, Luis A Soto, Rie von Eyben, Meghana A Golla, Yasaman Ahrari, Stavros Melemenidis, Anosheh Afghahi, Melissa J Jenkins, Allison W Kurian, Kathleen Horst, Amato J Giaccia, Edward E Graves
Although radiation therapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy (BCT). The relationship between RT and local recurrence is unknown. Here we tested the hypothesis that recurrence in some instances is due to the attraction of circulating tumor cells to irradiated tissues. To evaluate the effect of absolute lymphocyte count on local recurrence after RT in TNBC patients, we analyzed radiation effects on tumor and immune cell recruitment to tissues in an orthotopic breast cancer model...
June 7, 2018: Cancer Research
https://www.readbyqxmd.com/read/29869774/comparison-of-tumor-infiltrating-lymphocytes-of-breast-cancer-in-core-needle-biopsies-and-resected-specimens-a-retrospective-analysis
#13
Yoon Jin Cha, Sung Gwe Ahn, Soong June Bae, Chang Ik Yoon, Jayeong Seo, Woo Hee Jung, Eun Ju Son, Joon Jeong
PURPOSE: Neoadjuvant chemotherapy (NAC) is being increasingly used to treat locally advanced breast cancer and to conserve the breast. In triple-negative breast cancer and HER2-positive breast cancer, a high density of tumor-infiltrating lymphocytes (TILs) is an important predictor of NAC response. Thus far, it remains unclear whether the TIL scores in core needle biopsies (CNBs) are closely representative of those in the whole tumor section in resected specimens. This study aimed to evaluate the concordance between the TIL scores of CNBs and resected specimens of breast cancer...
June 5, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29861803/efficacy-of-pectoral-nerve-block-type-ii-for-breast-conserving-surgery-and-sentinel-lymph-node-biopsy-a-prospective-randomized-controlled-study
#14
Doo-Hwan Kim, Sooyoung Kim, Chan Sik Kim, Sukyung Lee, In-Gyu Lee, Hee Jeong Kim, Jong-Hyuk Lee, Sung-Moon Jeong, Kyu Taek Choi
Objectives: The pectoral nerve block type II (PECS II block) is widely used for postoperative analgesia after breast surgery. This study evaluated the analgesic efficacy of PECS II block in patients undergoing breast-conserving surgery (BCS) and sentinel lymph node biopsy (SNB). Methods: Patients were randomized to the control group ( n =40) and the PECS II group ( n =40). An ultrasound-guided PECS II block was performed after induction of anesthesia. The primary outcome measure was opioid consumption, and the secondary outcome was pain at the breast and axillary measured using the Numerical Rating Scale (NRS) 24 hours after surgery...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29860762/-clinical-characteristics-and-prognosis-of-patients-with-ipsilateral-breast-tumor-recurrence-after-breast-conservation-therapy
#15
G Y Sun, S L Wang, Y Tang, J Jin, Y W Song, Y P Liu, W H Wang, H Fang, S Y Chen, H Ren, X F Liu, Z H Yu, Y X Li
Objective: To analyze the clinical features and prognosis of the ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery. Methods: From 1999 to 2013, 63 women with IBTR after breast conserving surgery were retrospectively reviewed. All patients had adequate information on tumor location both at first presentation and at recurrence, with or without regional recurrence or distant metastasis. The histologic changes between true local recurrence and elsewhere recurrence groups were compared. The local recurrence, the overall survival after IBTR (IBTR-OS), the disease-free survival after IBTR (IBTR-DFS) were also compared...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29860761/-the-effect-of-axillary-lymph-node-status-on-the-prognosis-of-patients-with-local-regional-recurrence-after-breast-conserving-surgery
#16
Z Zhang, W Zhang, Z J Li, X M Wang, X C Cao, C H Xiao
Objective: To investigate the effect of axillary lymph node status in evaluating the prognosis of patients with local recurrence after breast-conserving surgery. Methods: The clinical data of 72 patients with local-regional recurrence who had undergone breast-conserving therapy in Tianjin Cancer Hospital from February 2001 to December 2009 were collected and retrospectively analyzed. These patients were divided into axillary lymph node positive group (23 cases) and negative group (49 cases), according to their axillary lymph node status...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29860760/-the-influence-of-molecular-classification-of-breast-cancer-on-the-safety-of-breast-conserving-surgery
#17
Y Li, L Mu, Y X Ruan, Y T Wang, D Zhang, H Zhou, X Wang
Objective: To analyze the relationship between the breast cancer molecular classification and the prognosis of patients underwent breast-conserving therapy and to discuss the safety of the breast conserving surgery from the choice of operation in terms of breast cancer molecular classification. Methods: Clinical data of 618 patients with breast-conserving therapy in Tianjin Medical University Cancer Institute and Hospital from August 2005 to August 2010 were analyzed retrospectively. According to the molecular classification when breast cancer was diagnosed, patients were subdivided into five groups, including Luminal A, Luminal B1, Luminal B2, HER-2-positive and Triple-negative...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29859789/hypofractionated-whole-breast-irradiation-in-women-less-than-50-years-old-treated-on-4-prospective-protocols
#18
Fauzia Shaikh, Jessica Chew, Tsivia Hochman, Juhi Purswani, Olivier Maisonet, Elecia Peat, Nelly Huppert, Benjamin T Cooper, Moses Tam, Judith D Goldberg, Carmen A Perez, Silvia C Formenti, Naamit K Gerber
PURPOSE: Hypofractionated whole-breast radiation therapy (RT) has proved to be equivalent to conventionally fractionated RT in multiple randomized trials. There is controversy regarding its use in younger women because of their underrepresentation in trials and the concern for late toxicity. We evaluated disease control and cosmetic outcomes in patients aged <50 years treated with hypofractionated RT in 4 prospective single-institutional trials. METHODS AND MATERIALS: From 2003 to 2015, 1313 patients were enrolled in 4 prospective protocols investigating the use of adjuvant hypofractionated RT after breast-conserving surgery with a daily or weekly concomitant boost...
April 19, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29857853/mri-based-quantification-of-residual-fibroglandular-tissue-of-the-breast-after-conservative-mastectomies
#19
Ramona Woitek, Georg Pfeiler, Alex Farr, Panagiotis Kapetas, Julia Furtner, Maria Bernathova, Veronika Schöpf, Paola Clauser, Maria A Marino, Katja Pinker, Pascal A Baltzer, Thomas H Helbich
PURPOSE: Skin-sparing and nipple-sparing mastectomies (SSM; NSM) remove the breast's fibroglandular tissue (FGT), thereby reducing breast cancer risk. The postoperative presence of residual FGT (RFGT) is associated with remaining cancer risk. This study evaluated the role of MRI in the quantitative assessment of RFGT and its impact on the estimation of the remaining breast cancer risk. METHODS: The postoperative MRI scans (following EUSOMA recommendations) of 58 patients who had undergone SSM or NSM between 2003 and 2013, as well as preoperative MRI scans that were available in 25 of these patients, were retrospectively evaluated for the presence and location of RFGT by three radiologists...
July 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29850375/linear-regression-model-to-identify-the-factors-associated-with-carbon-stock-in-chure-forest-of-nepal
#20
Ira Sharma, Sampurna Kakchapati
Use of woody plants for greenhouse gas mitigation has led to the demand for rapid cost-effective estimation of forest carbon stock and related factors. This study aims to assess the factors associated with carbon stock in Chure forest of Nepal. The data were obtained from Department of Forest Research and Survey (DFRS) of Nepal. A multiple linear regression model and then sum contrasts were used to observe the association between variables such as stem volume, diameter at breast height, altitude, districts, number of trees per plot, and ownership of the forest...
2018: Scientifica
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