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https://www.readbyqxmd.com/read/28324266/quality-of-life-in-patients-with-recurrent-breast-cancer-after-second-breast-conserving-therapy-in-comparison-with-mastectomy-the-german-experience
#1
Svenja Jendrian, Katharina Steffens, Barbara Schmalfeldt, Elena Laakmann, Corinna Bergelt, Isabell Witzel
BACKGROUND: Although some studies suggest that breast-conserving therapy (BCT) shows better psychosocial outcomes than mastectomy in patients with primary breast cancer, little is known about the outcomes of these surgical options in recurrent breast cancer. We investigated differences in overall survival and re-recurrence rates as well as psychosocial outcomes among patients who underwent BCT or mastectomy after the diagnosis of recurrent breast cancer in a single-center setting. METHODS: 124 of 186 eligible patients who underwent surgical treatment for breast cancer recurrence completed the questionnaires on quality of life (EORTC QLQ-C30 and -BR23), fear of progression (PA-F-KF), anxiety and depression (HADS), and body image (BIS)...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28315967/relationship-of-breast-mri-to-recurrence-rates-in-patients-undergoing-breast-conservation-treatment
#2
Maureen V Hill, Julia L Beeman, Khushboo Jhala, Stefan D Holubar, Kari M Rosenkranz, Richard J Barth
PURPOSE: The effect of pre-operative MRI on the in-breast tumor recurrence rate (IBTR) of patients undergoing breast-conservation treatment (BCT) remains uncertain. We began to routinely perform pre-operative MRI in 2006. Our goal was to determine the effect of pre-operative MRI on IBTR. METHODS: Retrospective review of a prospective database of all patients undergoing BCT (n = 1396) from 2000 to 2010. IBTR were calculated using Kaplan-Meier estimates. RESULTS: 664 (47...
March 18, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28302118/ybx1-gene-silencing-inhibits-migratory-and-invasive-potential-via-coro1c-in-breast-cancer-in-vitro
#3
Jia Pei Lim, Sukanya Shyamasundar, Jayantha Gunaratne, Olivia Jane Scully, Ken Matsumoto, Boon Huat Bay
BACKGROUND: Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies, including breast cancer. Despite reports of YB-1 and its association with distant spread of breast cancer, the intrinsic mechanism underlying this observation remains elusive. This study investigates the role of YB-1 in mediating metastasis in highly invasive breast cancer cell lines. METHODS: Silencing the YBX1 gene (which encodes the YB-1 protein) by small interfering RNA (siRNA) was performed in MDA-MB-231 and Hs578T breast cancer cell lines, followed by phenotypic assays including cell migration and invasion assays...
March 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28301555/risk-factors-for-delay-of-adjuvant-chemotherapy-in-non-metastatic-breast-cancer-patients-a-systematic-review-and-meta-analysis-involving-186982-patients
#4
Xiaofang He, Fen Ye, Bingcheng Zhao, Hailin Tang, Jin Wang, Xiangsheng Xiao, Xiaoming Xie
PURPOSE: Delay performance of adjuvant chemotherapy (AC) after surgery has been presented to affect survival of breast cancer patients adversely, but the risk factors for delay in initiation remain controversial. Therefore, we conducted this systematic review of the literature and meta-analysis aiming at identifying the risk factors for delay of adjuvant chemotherapy (DAC) in non-metastatic breast cancer patients. METHODS: The search was performed on PubMed, Embase, Chinese National Knowledge Infrastructure and Wanfang Database from inception up to July 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28301261/a-radiolabeled-fully-human-antibody-to-human-aspartyl-asparaginyl-%C3%AE-hydroxylase-is-a-promising-agent-for-imaging-and-therapy-of-metastatic-breast-cancer
#5
Ekaterina Revskaya, Zewei Jiang, Alfred Morgenstern, Frank Bruchertseifer, Muctarr Sesay, Susan Walker, Steven Fuller, Michael S Lebowitz, Claudia Gravekamp, Hossein A Ghanbari, Ekaterina Dadachova
There is a need for novel effective and safe therapies for metastatic breast cancer based on targeting tumor-specific molecular markers of cancer. Human aspartyl (asparaginyl) β-hydroxylase (HAAH) is a highly conserved enzyme that hydroxylates epidermal growth factor-like domains in transformation-associated proteins and is overexpressed in a variety of cancers, including breast cancer. A fully human monoclonal antibody (mAb) PAN-622 has been developed to HAAH. In this study, they describe the development of PAN-622 mAb as an agent for imaging and radioimmunotherapy of metastatic breast cancer...
March 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28299890/a-case-of-adenomyoepithelioma-of-the-breast-showing-strong-uptake-of-18-f-fluorodeoxyglucose-on-a-positron-emission-tomography
#6
Takaaki Oba, Kazuma Maeno, Mayu Ono, Asumi Iesato, Tokiko Ito, Toshiharu Kanai, Yasuhiro Mochizuki, Ken-Ichi Ito, Akihiko Yoshizawa, Fumiyoshi Takayama
An adenomyoepithelioma of the breast is a rare tumor characterized by biphasic proliferation of both epithelial and myoepithelial cells. This tumor is generally considered as a benign neoplasm, and there are few reports describing the imaging features of this tumor through (18) F-fluorodeoxyglucose positron emission tomography (FDG-PET). Here, we report a case of an adenomyoepithelioma that showed strong uptake of FDG on PET similar to that observed with a malignant tumor. A 73-year-old woman presented to our hospital with a 3...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28295903/feasibility-of-intraoperative-breast-mri-and-the-role-of-prone-versus-supine-positioning-in-surgical-planning-for-breast-conserving-surgery
#7
Melissa A Mallory, Yasuaki Sagara, Fatih Aydogan, Stephen DeSantis, Jagadeesan Jayender, Diana Caragacianu, Eva Gombos, Kirby G Vosburgh, Ferenc A Jolesz, Mehra Golshan
We assessed the feasibility of supine intraoperative MRI (iMRI) during breast-conserving surgery (BCS), enrolling 15 patients in our phase I trial between 2012 and 2014. Patients received diagnostic prone MRI, BCS, pre-excisional supine iMRI, and postexcisional supine iMRI. Feasibility was assessed based on safety, sterility, duration, and image-quality. Twelve patients completed the study; mean duration = 114 minutes; all images were adequate; no complications, safety, or sterility issues were encountered...
March 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28293119/intensity-modulated-radiation-therapy-for-breast-cancer-current-perspectives
#8
REVIEW
Milly Buwenge, Silvia Cammelli, Ilario Ammendolia, Giorgio Tolento, Alice Zamagni, Alessandra Arcelli, Gabriella Macchia, Francesco Deodato, Savino Cilla, Alessio G Morganti
BACKGROUND: Owing to highly conformed dose distribution, intensity modulated radiation therapy (IMRT) has the potential to improve treatment results of radiotherapy (RT). Postoperative RT is a standard adjuvant treatment in conservative treatment of breast cancer (BC). The aim of this review is to analyze available evidence from randomized controlled trials (RCTs) on IMRT in BC, particularly in terms of reduction of side effects. METHODS: A literature search of the bibliographic database PubMed, from January 1990 through November 2016, was performed...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28292995/-a-case-of-stage-iv-breast-cancer-with-long-term-survival-by-chemotherapy-developing-pulmonary-tumor-thrombotic-microangiopathy-during-the-treatment-course
#9
Kana Kobayashi, Akari Murakami, Saaya Komatsu, Kanako Nishiyama, Michiko Yamashita, Wakana Sugimori, Yoshiaki Kamei, Hiroaki Asai, Akiyoshi Ogimoto, Kazuo Honda, Yasutsugu Takada
Pulmonary tumor thrombotic microangiopathy(PTTM)caused by pulmonary artery microscopic tumor emboli and fibrocellular and/or fibromuscular proliferation leads to progressive pulmonary hypertension and respiratory failure.The prognosis is extremely poor and most patients die shortly after onset.We report a patient with Stage IV breast cancer and long-term survival who developed PTTM during chemotherapy treatment.A 63-year-old woman with multiple metastases in her cerebellum, bone, lung, and lymph node after left breast conserving surgery started to experience dyspnea and malaise 7 years after the surgery...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28292493/patient-preferences-for-minimally-invasive-and-open-locoregional-treatment-for-early-stage-breast-cancer
#10
Floortje M Knuttel, Maurice A A J van den Bosch, Danny A Young-Afat, Marleen J Emaus, Desirée H J G van den Bongard, Arjen J Witkamp, Helena M Verkooijen
BACKGROUND: Noninvasive or minimally invasive treatments are being developed as alternatives to surgery for patients with early-stage breast cancer. Patients' preferences with regard to these new treatments have not been investigated. OBJECTIVES: To assess preferences of patients with breast cancer and of healthy women regarding these new techniques, compared with conventional surgical treatments. METHODS: Six hypothetical breast cancer treatment-outcome scenarios were developed: three standard surgical scenarios (mastectomy, mastectomy with immediate implant-based reconstruction, and breast-conserving therapy [BCT]) and three minimally invasive or noninvasive scenarios (radiofrequency ablation, magnetic resonance-guided high-intensity focused ultrasound ablation, and single-dose ablative radiotherapy)...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28292293/batwing-versus-wise-pattern-mammoplasty-for-upper-pole-breast-tumours-a-detailed-comparison-of-cosmetic-outcome
#11
Tarek Hashem, Ahmed Farahat
BACKGROUND: The aim of this study is to compare the results of batwing mammoplasty and Wise pattern mammoplasty in the surgical management of upper pole breast tumours. METHODS: This is a retrospective observational study including 126 breast cancer patients who presented between 2009 and 2015 to the National Cancer Institute of Cairo University in Egypt. All patients were candidates for breast conservation, with upper pole tumours, which was defined as tumours between 3 and 9 o'clock...
March 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28289662/mucosa-associated-lymphoid-tissue-lymphoma-of-the-cecum-and-rectum-a-case-report
#12
Myung Jin Nam, Byung Chang Kim, Sung Chan Park, Chang Won Hong, Kyung Su Han, Dae Kyung Sohn, Weon Seo Park, Hee Jin Chang, Jae Hwan Oh
A colonic mucosa-associated lymphoid-tissue (MALT) lymphoma is relatively rare compared to lymphomas of the stomach or small intestine. We present a case of a MALT lymphoma in the cecum and rectum found during screening colonoscopy. A 54-year-old female, who had undergone right-breast-conserving surgery with axillary dissection due to an invasive ductal carcinoma and a left-breast excisional biopsy due to microcalcification following adjuvant chemoradiation therapy 3 years earlier, was found to have 3-mm-sized smooth elevated lesions in both the cecum and rectum...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28289080/microrna-applications-for-prostate-ovarian-and-breast-cancer-in-the-era-of-precision-medicine
#13
Bethany Smith, Priyanka Agarwal, Neil A Bhowmick
The high degree of conservation in microRNA from Caenorhabditis elegans to humans has enabled relatively rapid implementation of findings in model systems to the clinic. The convergence of the capacity for genomic screening being implemented in the prevailing precision medicine initiative and the capabilities of microRNA to address these changes holds significant promise. However, prostate, ovarian, and breast cancers are heterogeneous and face issues of evolving therapeutic resistance. Transforming growth factor-beta (TGF-ß) signaling axis plays an important role in the progression of each of these cancers, in part through microRNA regulation, and reciprocally, microRNA regulation of TGF-ß actions...
March 13, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28284519/breast-conserving-surgery-and-locoregional-control-after-neoadjuvant-chemotherapy
#14
REVIEW
M Teshome, H M Kuerer
The management of breast malignancy and the role of neoadjuvant systemic therapy has continued to evolve over the past 50 years. Survival equivalence with adjuvant systemic therapy is well accepted and demonstrated in several clinical trials. However, strong association with survival outcome and pathologic complete response emerged. Assessment of tumor response, as a surrogate for outcome, continues to be a driver for neoadjuvant therapy with increased applicability in the setting of sophisticated understanding and implications of breast tumor biology and molecular subtype...
February 12, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28282587/feasibility-of-magnetic-marker-localisation-for-non-palpable-breast-cancer
#15
B Schermers, J A van der Hage, C E Loo, M T F D Vrancken Peeters, H A O Winter-Warnars, F van Duijnhoven, B Ten Haken, S H Muller, T J M Ruers
OBJECTIVES: Accurate tumour localisation is essential for breast-conserving surgery of non-palpable tumours. Current localisation technologies are associated with disadvantages such as logistical challenges and migration issues (wire guided localisation) or legislative complexities and high administrative burden (radioactive localisation). We present MAgnetic MArker LOCalisation (MaMaLoc), a novel technology that aims to overcome these disadvantages using a magnetic marker and a magnetic detection probe...
March 7, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28281862/model-based-approach-for-quantitative-estimates-of-skin-heart-and-lung-toxicity-risk-for-left-side-photon-and-proton-irradiation-after-breast-conserving-surgery
#16
Francesco Tommasino, Marco Durante, Vittoria D'Avino, Raffaele Liuzzi, Manuel Conson, Paolo Farace, Giuseppe Palma, Marco Schwarz, Laura Cella, Roberto Pacelli
BACKGROUND: Proton beam therapy represents a promising modality for left-side breast cancer (BC) treatment, but concerns have been raised about skin toxicity and poor cosmesis. The aim of this study is to apply skin normal tissue complication probability (NTCP) model for intensity modulated proton therapy (IMPT) optimization in left-side BC. MATERIAL AND METHODS: Ten left-side BC patients undergoing photon irradiation after breast-conserving surgery were randomly selected from our clinical database...
March 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28279888/validation-of-the-electronic-version-of-the-breast-q-in-the-army-of-women-study
#17
Sarah Fuzesi, Stefan J Cano, Anne F Klassen, Dunya Atisha, Andrea L Pusic
Women undergoing surgery for primary breast cancer can choose between breast conserving therapy and mastectomy (with or without breast reconstruction). Patients often turn to outcomes data to help guide the decision-making process. The BREAST-Q is a validated breast surgery-specific patient-reported outcome measure that evaluates satisfaction, quality of life, and patient experience. It was originally developed for paper-and-pencil administration. However, the BREAST-Q has increasingly been administered electronically...
March 6, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28274254/the-use-of-randomisation-based-efficacy-estimators-in-non-inferiority-trials
#18
David Gillespie, Daniel Farewell, Peter Barrett-Lee, Angela Casbard, Anthony Barney Hawthorne, Chris Hurt, Nick Murray, Chris Probert, Rachel Stenson, Kerenza Hood
BACKGROUND: In a non-inferiority (NI) trial, analysis based on the intention-to-treat (ITT) principle is anti-conservative, so current guidelines recommend analysing on a per-protocol (PP) population in addition. However, PP analysis relies on the often implausible assumption of no confounders. Randomisation-based efficacy estimators (RBEEs) allow for treatment non-adherence while maintaining a comparison of randomised groups. Fischer et al. have developed an approach for estimating RBEEs in randomised trials with two active treatments, a common feature of NI trials...
March 9, 2017: Trials
https://www.readbyqxmd.com/read/28274211/redefining-radiotherapy-for-early-stage-breast-cancer-with-single-dose-ablative-treatment-a-study-protocol
#19
R K Charaghvandi, B van Asselen, M E P Philippens, H M Verkooijen, C H van Gils, P J van Diest, R M Pijnappel, M G G Hobbelink, A J Witkamp, T van Dalen, E van der Wall, T C van Heijst, R Koelemij, M van Vulpen, H J G D van den Bongard
BACKGROUND: A shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial breast irradiation (APBI) is an alternative for whole breast irradiation following breast-conserving surgery. MRI-guided single dose ablative APBI has the potential to offer a minimally burdening, non-invasive treatment that could replace current breast-conserving therapy. METHODS: The ABLATIVE study is a prospective, single arm, multicenter study evaluating preoperative, single dose, ablative radiation treatment in patients with early-stage breast cancer...
March 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28273552/surgeon-performed-continuous-intraoperative-ultrasound-guidance-decreases-re-excisions-and-mastectomy-rates-in-breast-cancer
#20
Guldeniz Karadeniz Cakmak, Ali U Emre, Oge Tascilar, Burak Bahadir, Selcuk Ozkan
BACKGROUND: Intraoperative ultrasound guided (IUG) breast conserving surgery (BCS) is being increasingly embraced by breast surgeons worldwide. We aimed to compare the efficacy of IUG-BCS for palpable and nonpalpable breast cancer with respect to margin status, re-excision rate, tissue sacrifice and cost-time analysis. METHODS: Intraoperative localization protocol includes intraoperative ultrasound prior to excision to localize the lesion and guide the initial resection...
March 2, 2017: Breast: Official Journal of the European Society of Mastology
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