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https://www.readbyqxmd.com/read/29048330/calibration-and-analysis-of-a-multimodal-micro-ct-and-structured-light-imaging-system-for-the-evaluation-of-excised-breast-tissue
#1
David Martin McClatchy Iii, Elizabeth J Rizzo, Jeff Meganck, Josh Kempner, Jared Vicory, Wendy A Wells, Keith D Paulsen, Brian W Pogue
A multimodal micro-computed tomography (CT) and multi-spectral structured light imaging (SLI) system is introduced and systematically analyzed to test its feasibility to aid in margin delineation during breast conserving surgery (BCS). Phantom analysis of the micro-CT yielded a signal-to-noise ratio (SNR) of 34, a contrast of 1.64, and a minimum detectable resolution of 240 m for a 1.2 min scan. The SLI system, spanning wavelengths 490 nm to 800 nm and spatial frequencies up to 1.37 mm-1, was evaluated with aqueous tissue simulating phantoms having variations in particle size distribution, scatter density, and blood volume fraction...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29033401/construction-of-c35-gene-bait-recombinants-and-t47d-cell-cdna-library
#2
Kun Yin, Chao Xu, Gui-Hua Zhao, Ye Liu, Ting Xiao, Song Zhu, Ge Yan
C35 is a novel tumor biomarker associated with metastasis progression. To investigate the interaction factors of C35 in its high expressed breast cancer cell lines, we constructed bait recombinant plasmids of C35 gene and T47D cell cDNA library for yeast two-hybrid screening. Full length C35 sequences were subcloned using RT-PCR from cDNA template extracted from T47D cells. Based on functional domain analysis, the full-length C351-348bp was also truncated into two fragments C351-153bp and C35154-348bp to avoid auto-activation...
October 16, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29033142/discussion-of-re-excision-rates-after-breast-conserving-surgery-following-the-2014-sso-astro-guidelines
#3
Alicia Heelan Gladden
No abstract text is available yet for this article.
September 30, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29032999/a-prospective-phase-i-comparison-of-toxicity-and-cosmesis-outcomes-of-single-fraction-iort-and-hypofractionated-radiotherapy-with-iort-boost-in-early-stage-breast-cancer
#4
Tanuja Bhandari, Wesley Babaran, Afshin Forouzannia, Venita Williams, Jay Harness, Michele Carpenter, Maher Gobran, Rajesh Khanijou, Brittany Wagman, Robert Ash, Lawrence D Wagman
PURPOSE: Radiation therapy is proven to reduce local recurrence in patients with early-stage breast cancer. To reduce toxicity, treatment time, and improve accuracy, intraoperative radiation therapy was used as definitive treatment or as a boost. The study's objective was to compare the short-term toxicity and cosmesis of single-fraction (SF) IORT and hypofractionated radiotherapy with IORT boost (HfB) given as definitive treatment. METHODS AND MATERIALS: Between March 2011 and December 2013, 57 patients aged 45-91 years and 24 patients aged 43-83 years (total n = 81) with Stage 0-II were treated with SF or HfB (Mobetron, IntraOp Medical, Sunnyvale, CA)...
October 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29031423/the-state-of-surgical-axillary-management-and-adjuvant-radiotherapy-for-early-stage-invasive-breast-cancer-in-the-modern-era
#5
Justin M Mann, Xian Wu, Paul Christos, Himanshu Nagar
BACKGROUND: For clinical T1-2N0 breast cancer, sentinel lymph node biopsy (SLNB) has been shown in American College of Surgeons Oncology Group (ACOSOG) Z0011 to be sufficient for women with 1 to 2 positive sentinel lymph nodes with no added benefit for completion axillary lymph node dissection (ALND). Z0011 specified whole breast radiotherapy (RT) using standard tangential fields; however, later analysis showed variation in field design. We assessed nationwide practice patterns and examined factors associated with patients undergoing completion ALND and subsequent radiation field design...
September 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29030916/identification-and-characterization-of-a-metastatic-suppressor-brms1l-as-a-target-gene-of-p53
#6
Ryota Koyama, Miyuki Tamura, Takafumi Nakagaki, Tomoko Ohashi, Masashi Idogawa, Hiromu Suzuki, Takashi Tokino, Yasushi Sasaki
The tumor suppressor p53 and its family members, p63 and p73, play a pivotal role in the cell fate determination in response to diverse upstream signals. As transcription factors, p53 family proteins regulate a number of genes that are involved in cell-cycle arrest, apoptosis, senescence, and maintenance of genomic stability. Recent studies revealed that p53 family proteins are important for the regulation of cell invasion and migration. Microarray analysis showed that breast cancer metastasis-suppressor 1- like (BRMS1L) is upregulated by p53 family proteins, specifically p53, TAp63γ, and TAp73β...
October 13, 2017: Cancer Science
https://www.readbyqxmd.com/read/29030030/oncological-safety-of-nipple-sparing-prophylactic-mastectomy-a-review-of-the-literature-on-3716-cases
#7
T Muller, A Baratte, C Bruant-Rodier, F Bodin, C Mathelin
INTRODUCTION: The objective of our study was to evaluate the risk of cancer after prophylactic nipple-sparing mastectomy (PNSM). MATERIAL AND METHODS: The PubMed database was consulted using the following key-words: "nipple-sparing mastectomy", "prophylactic", "locoregional recurrence", "oncological risk". Articles published between January 1995 and December 2016 were searched. RESULTS: Out of the 270 articles found, 19 were included. Overall, 15 studies were retrospective, 2 prospective, 2 prospective and retrospective and 3 were multicentric...
October 10, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29029503/slingshot-1l-a-cofilin-phosphatase-induces-primary-breast-cancer-metastasis
#8
Chen Chen, Yusufu Maimaiti, Shen Zhijun, Liu Zeming, Guo Yawen, Yu Pan, Huang Tao
Slingshot (SSH) is a member of the conserved family of cofilin phosphatases that plays a critical role in cell membrane protrusion and migration by transforming inactive phosphorylated cofilin to an active form. SSH-like protein 1 (SSH-1L) expression is detected in various types of tumors; insulin induces the phosphatases activity of SSH-1L in a phosphoinositide 3-kinase-dependent manner. However, little is known about the expression and role of SSH-1L in breast cancer. Here, we analyzed 295 human breast cancer tissue specimens for SSH-1L expression by immunohistochemistry...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29019894/randomized-controlled-trial-of-late-course-concurrent-versus-sequential-chemoradiotherapy-after-mastectomy-and-axillary-surgery-in-locally-advanced-breast-cancer
#9
RANDOMIZED CONTROLLED TRIAL
Ying Lu, Haixin Huang, Hui Yang, Dagui Chen
BACKGROUND: Concurrent chemoradiotherapy could increase the local control rate in patients with high recurrence risk after breast-conserving surgery, but the effect of concurrent chemoradiotherapy after mastectomy and axillary dissection is not clear. The aim of the study was to compare the effects of late-course concurrent chemoradiotherapy (CCRT) versus sequential therapy (SCRT) after mastectomy and axillary surgery in locally advanced breast cancer. METHODS: This was a randomized controlled trial of 155 patients with stage pT3-4p N1-3c M0 or pAnyT pN2-3c M0 breast cancer undergoing 5-fluorouracil+epirubicin+cyclophosphamide followed by docetaxel (FEC-D) chemotherapy after mastectomy and axillary dissection...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29017170/impact-of-typhoon-haiyan-on-a-philippine-tarsier-population
#10
Sharon Gursky, Cristina Salibay, Nanda Grow, Lori Fields
Over the last 2 decades the Philippine tarsier (Carlito syrichta aka Tarsius syrichta) has had its conservation status revised from Endangered to Data Deficient to Near Threatened. The last status change was based on a study of the species' population density, which suggested that a single natural catastrophe could potentially wipe out the Philippine tarsier. In 2013 typhoon Haiyan hit Bohol, one of the island strongholds for this species. In this study we compare the density of the Bohol tarsier population within the Philippine Tarsier and Wildlife Sanctuary before and after the typhoon...
October 11, 2017: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/29017163/ptis-and-pt1a-ipsilateral-breast-tumor-recurrence-is-associated-with-good-prognosis-after-salvage-surgery
#11
Makoto Ishitobi, Reiko Fukui, Yoko Hashimoto, Nobuyoshi Kittaka, Takahiro Nakayama, Yasuhiro Tamaki
OBJECTIVES: Patients with ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery have a poor prognosis. There is little information regarding the prognostic impact of the tumor size in patients with IBTR. METHODS: A total of 143 patients who had histologically confirmed IBTR without distant metastases and who underwent salvage surgery between 1989 and 2013 in our hospital were included. Distant disease-free survival (DDFS) was calculated according to the invasive tumor size of IBTR...
October 11, 2017: Oncology
https://www.readbyqxmd.com/read/28991362/axillary-tumour-burden-in-women-with-a-fine-needle-aspiration-core-biopsy-proven-positive-node-on-ultrasonography-compared-to-women-with-a-positive-sentinel-node
#12
P Lloyd, E Theophilidou, R G Newcombe, L Pugh, A Goyal
BACKGROUND: The sensitivity of axillary ultrasonography (AUS) has increased in recent years, enabling detection of even low-volume axillary nodal metastases. The aim here was to evaluate the axillary tumour burden in women with a fine-needle aspiration/core biopsy-proven positive node on AUS and in those with a positive sentinel node biopsy (SNB). METHODS: This retrospective cohort study included all patients with early breast cancer who had AUS and axillary lymph node dissection (ALND) between 2011 and 2014...
October 9, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28990314/female-breast-cancer-management-and-survival-the-experience-of-major-public-hospitals-in-south-australia-over-3-decades-trends-by-age-and-in-the-elderly
#13
David Roder, Gelareh Farshid, Jim Kollias, Bogda Koczwara, Christos Karapetis, Jacqui Adams, Rohit Joshi, Dorothy Keefe, Caroline Miller, Kate Powell, Kellie Fusco, Marion Eckert, Elizabeth Buckley, Kerri Beckmann, Timothy Price
BACKGROUND: Clinical registry data from major South Australian public hospitals were used to investigate trends in invasive breast-cancer treatment and survival by age. METHODS: Disease-specific survival was calculated for the 1980 to 2013 diagnostic period using Kaplan-Meier product-limit estimates, with a censoring of live cases on December 31, 2014. Cox proportional hazards regression was used to examine differences in survival by age and tumour characteristic...
October 8, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28990127/patterns-of-axillary-evaluation-in-older-patients-with-breast-cancer-and-associations-with-adjuvant-therapy-receipt
#14
Laura S Dominici, Helmneh M Sineshaw, Ahmedin Jemal, Chun Chieh Lin, Tari A King, Rachel A Freedman
PURPOSE: Although axillary lymph node status has traditionally been a key factor in informing adjuvant breast cancer therapy recommendations, this information may be less relevant as our focus shifts more towards tumor biology, particularly in older patients where comorbidity influences treatment decisions and nodal staging and/or surgery may not improve outcomes. We examined patterns of axillary surgery and associations between axillary surgery and receipt of adjuvant treatment in older breast cancer patients...
October 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28989927/metastatic-uterine-cancer-looking-as-cervical-fibroid-in-recurrent-breast-cancer-woman-a-case-report
#15
So Young Seo, Jin Yong Shin, Yong Il Ji
Metastasis to the female genital tract from extragenital primary cancer is uncommon. In this case, a 46-year-old woman was diagnosed with invasive lobular carcinoma of the left breast in 2011. She had left breast conserving surgery, chemotherapy, radiation, and hormonal therapy (gosereline and tamoxifen). However, she developed menorrhagia after interruption of hormonal therapy and incidentally, the ultrasonogram of her pelvis showed a solid, large mass in the cervix. It looked like leiomyoma. Because of massive vaginal bleeding requiring multiple blood transfusions, she underwent total hysterectomy with bilateral salpingo-oophorectomy...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28989237/lipofilling-effects-after-breast-cancer-surgery-in-post-radiation-patients-an-analysis-of-results-and-algorithm-proposal
#16
Manuel Debald, Thomas Pech, Christina Kaiser, Mignon-Denise Keyver-Paik, Gisela Walgenbach-Bruenagel, Joerg C Kalff, Walther Kuhn, Klaus J Walgenbach
BACKGROUND: Lipofilling or autologous fat transfer is an established technique in plastic surgery. Herein, we describe the lipofilling effects after implant-based breast reconstruction in post-radiation patients and propose an algorithm for indication of lipofilling. METHODS: Forty patients with a history of breast cancer were included in this retrospective analysis. Patients had undergone either breast conserving therapy or mastectomy. Twenty-six patients underwent additional radiation therapy...
2017: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28987679/impact-of-mri-on-high-grade-ductal-carcinoma-insitu-hg-dcis-management-are-we-using-the-full-scope-of-mri
#17
Mohamad Hajaj, Ahmed Karim, Sana Pascaline, Lubna Noor, Shivali Patel, Mahmoud Dakka
INTRODUCTION: Preoperative assessment of pure Ductal Carcinoma Insitu (DCIS) is essential in the surgical planning. The role of Magnetic resonance imaging (MRI) has long been debated. The impact of MRI on the management of High Grade (HG) DCIS was assessed, whether it accurately captures the true size of this entity in comparison to conventional imaging, and, if MRI use would reduce the number of re-excision surgery. METHOD: Ninety-one consecutive patients with HG DCIS, who were identified from a prospectively collected data at Kettering General Hospital between April 2011 and December 2015...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987136/radiation-therapy-and-early-breast-cancer-current-controversies
#18
REVIEW
John Boyages
Radiation therapy (RT) is an important component of breast cancer treatment. RT reduces local recurrence and breast cancer mortality after breast conservation for all patients and for node-positive patients after a mastectomy. Short courses of RT over 3-4 weeks are generally as effective as longer courses. A patient subgroup where RT can be avoided after conservative surgery has not been consistently identified. A radiation boost reduces the risk of a recurrence in the breast but may be omitted for older patients with good prognosis tumours with clear margins...
August 4, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28985889/discussion-of-radioactive-seed-localization-for-breast-conservation-surgery-low-positive-margin-rate-with-no-learning-curve
#19
Richard Gray
No abstract text is available yet for this article.
September 30, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28984579/follow-up-of-patients-undergoing-oncoplastic-surgery-more-palpable-masses-and-benign-biopsies
#20
Yoav Amitai, Orit Golan, Yoav Barnea, Joseph Klausner, Tehillah S Menes
BACKGROUND: Oncoplastic reconstruction is increasingly used in the management of women undergoing breast conserving surgery. We examined the findings on breast exam and imaging of patients who underwent breast conservation with or without oncoplastic reconstruction. OBJECTIVE: We hypothesized that patients undergoing immediate breast reconstruction would present with more palpable and imaging abnormalities compared to lumpectomy alone and undergo therefore more biopsies...
October 3, 2017: Breast Disease
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