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https://www.readbyqxmd.com/read/29471387/heavy-cannabis-use-associated-with-reduction-in-activated-and-inflammatory-immune-cell-frequencies-in-antiretroviral-therapy-treated-human-immunodeficiency-virus-infected-individuals
#1
Jennifer A Manuzak, Toni M Gott, Jay S Kirkwood, Ernesto Coronado, Tiffany Hensley-McBain, Charlene Miller, Ryan K Cheu, Ann C Collier, Nicholas T Funderburg, Jeffery N Martin, Michael C Wu, Nina Isoherranen, Peter W Hunt, Nichole R Klatt
Background: Cannabis is a widely used drug in the United States, and the frequency of cannabis use in the human immunodeficiency virus (HIV)-infected population is disproportionately high. Previous human and macaque studies suggest that cannabis may have an impact on plasma viral load; however, the relationship between cannabis use and HIV-associated systemic inflammation and immune activation has not been well defined. Methods: The impact of cannabis use on peripheral immune cell frequency, activation, and function was assessed in 198 HIV-infected, antiretroviral-treated individuals by flow cytometry...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471226/examining-effects-of-medical-cannabis-narratives-on-beliefs-attitudes-and-intentions-related-to-recreational-cannabis-a-web-based-randomized-experiment
#2
Sharon R Sznitman, Nehama Lewis
BACKGROUND: This experimental study tests effects of exposure to video narratives about successful symptom relief with Medical Cannabis (MC) on attitudes, beliefs, and intentions related to recreational cannabis use. METHODS: Patient video testimonials were modeled after those found in extant media coverage. Israeli participants (N = 396) recruited through an online survey company were randomly assigned to view a narrative or a non-narrative video containing equivalent information about MC...
January 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29471225/location-location-location-assessing-the-spatial-patterning-between-marijuana-licenses-alcohol-outlets-and-neighborhood-characteristics-within-washington-state
#3
Loni Philip Tabb, Christina Fillmore, Steven Melly
BACKGROUND: The availability of marijuana products is becoming increasingly prevalent across the United States (US), many states are allowing for the production, processing, and retailing of these products for medical and/or recreational use. The purpose of this study is to: (1) examine the spatial patterning of marijuana licenses, and (2) examine the impact of alcohol outlets in addition to other neighborhood characteristics on marijuana licenses within the state of Washington. METHODS: This cross-sectional observational study examined 1458 census tracts in Washington state from 2017, using marijuana and alcohol data from the Washington State Liquor and Cannabis Board as well as neighborhood characteristics data from the American Community Survey 2011-2015 5-year estimates...
February 13, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29470605/considering-the-context-social-factors-in-responses-to-drugs-in-humans
#4
REVIEW
Harriet de Wit, Michael Sayette
BACKGROUND: Drugs are typically used in social settings. Here, we consider two factors that may contribute to this observation: (i) the presence of other people may enhance the positive mood effects of a drug, and conversely, (ii) drugs may enhance the value of social stimuli. METHODS: We review evidence from controlled laboratory studies with human volunteers, which investigated either of these interactions between social factors and responses to drugs. We examine the bidirectional effects of social stimuli and single doses of alcohol, stimulants, opioids, and cannabis...
February 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29469245/antipsychotic-prescriptions-among-adults-with-major-depressive-disorder-in-office-based-outpatient-settings-national-trends-from-2006-to-2015
#5
Taeho Greg Rhee, Somaia Mohamed, Robert A Rosenheck
OBJECTIVE: A recent moderately long-term study found an antipsychotic to be more effective than an antidepressant as the next-step treatment of unresponsive major depressive disorder (MDD). It is thus timely to examine recent trends in the pharmacoepidemiology of antipsychotic treatment of MDD. METHODS: Data from the 2006-2015 National Ambulatory Medical Care Survey, nationally representative samples of office-based outpatient visits in adults with MDD (ICD-9-CM codes 296...
February 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29468760/it-is-premature-to-expand-access-to-medicinal-cannabis-in-hopes-of-solving-the-us-opioid-crisis
#6
EDITORIAL
Wayne Hall, Robert West, John Marsden, Keith Humphreys, Jo Neale, Nancy Petry
No abstract text is available yet for this article.
February 22, 2018: Addiction
https://www.readbyqxmd.com/read/29467679/the-endocannabinoid-system-across-postnatal-development-in-transmembrane-domain-neuregulin-1-mutant-mice
#7
Rose Chesworth, Leonora E Long, Cynthia Shannon Weickert, Tim Karl
The use of cannabis is a well-established component risk factor for schizophrenia, particularly in adolescent individuals with genetic predisposition for the disorder. Alterations to the endocannabinoid system have been found in the prefrontal cortex of patients with schizophrenia. Thus, we assessed whether molecular alterations exist in the endocannabinoid signalling pathway during brain development in a mouse model for the schizophrenia risk gene neuregulin 1 ( Nrg1 ). We analysed transcripts encoding key molecules of the endocannabinoid system in heterozygous transmembrane domain Nrg1 mutant mice ( Nrg1 TM HET), which is known to have increased sensitivity to cannabis exposure...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29467073/the-consumption-of-new-psychoactive-substances-and-methamphetamine
#8
Elena Gomes de Matos, Tessa-Virginia Hannemann, Josefine Atzendorf, Ludwig Kraus, Daniela Piontek
BACKGROUND: The abuse of new psychoactive substances (NPS) and methamphetamine has severe adverse effects. Here we provide the first report of regional patterns in NPS and methamphetamine consumption in Germany, on the basis of epidemiologic data from six federal states (Bavaria, Hamburg, Hesse, North Rhine-Westphalia, Saxony, and Thuringia). METHODS: Data were derived from the 2015 Epidemiological Survey of Substance Abuse (Epidemiologischer Suchtsurvey) and supplemented with additional cases from the federal states that were studied...
January 26, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29466945/diversity-and-evolution-of-the-repetitive-genomic-content-in-cannabis-sativa
#9
Rahul Pisupati, Daniela Vergara, Nolan C Kane
BACKGROUND: The repetitive content of the genome, once considered to be "junk DNA", is in fact an essential component of genomic architecture and evolution. In this study, we used the genomes of three varieties of Cannabis sativa, three varieties of Humulus lupulus and one genotype of Morus notabilis to explore their repetitive content using a graph-based clustering method, designed to explore and compare repeat content in genomes that have not been fully assembled. RESULTS: The repetitive content in the C...
February 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29466823/analytical-and-pharmacological-challenges-in-cannabis-research
#10
Jürg Gertsch
No abstract text is available yet for this article.
March 2018: Planta Medica
https://www.readbyqxmd.com/read/29466093/efficacy-of-a-web-based-tailored-intervention-to-reduce-cannabis-use-among-young-people-attending-adult-education-centers-in-quebec
#11
José Côté, Sébastien Tessier, Hélène Gagnon, Nicole April, Geneviève Rouleau, Miguel Chagnon
BACKGROUND: Cannabis use is common among young adults. Web-based interventions are an increasingly popular way to reach this population. The aim of this study was to evaluate the efficacy of a Web-based tailored intervention, developed on theoretical and empirical grounds, to reduce cannabis use among young people by promoting a more positive intention to abstain. METHODS: An experimental design was employed to evaluate the efficacy of the intervention in reducing cannabis use (primary outcome) by bolstering intention (secondary outcome) to abstain from use...
February 21, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29465739/analysis-of-trends-in-the-prevalence-of-cannabis-use-in-canada-1985-to-2015
#12
Michelle Rotermann, Ryan Macdonald
BACKGROUND: The Canadian federal government has committed to legalize, regulate, and restrict non-medical cannabis use by adults in 2018. To prepare for monitoring the health, social and economic impacts of this policy change, a greater understanding of the long-term trends in the prevalence of cannabis use in Canada is needed. DATA AND METHODS: Nine national surveys of the household population collected information about cannabis use during the period from 1985 through 2015...
February 21, 2018: Health Reports
https://www.readbyqxmd.com/read/29464872/time-dependent-effect-of-phytocannabinoid-treatments-in-fat-cells
#13
S Ramlugon, R-A Levendal, C L Frost
The objectives of this paper is to investigate, demonstrate, and compare the mechanism of action of phytocannabinoids as antidiabetic and anti-obesity agents in preadipocytes and adipocytes, relative to rosiglitazone and metformin. Briefly, cannabis extract, Δ9 -tetrahydrocannabinol and cannabidiol (in very low dosages) were shown to promote glucose uptake higher or to equivalent levels, reduce fat accumulation, and reverse the insulin-resistant state of 3T3-L1 cells more effectively, relative to rosiglitazone and metformin...
February 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29464794/in-consideration-of-cannabis
#14
Amanda Reiman
No abstract text is available yet for this article.
February 21, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29464313/nuclear-chloroplast-and-mitochondrial-data-of-a-us-cannabis-dna-database
#15
Rachel Houston, Matthew Birck, Bobby LaRue, Sheree Hughes-Stamm, David Gangitano
As Cannabis sativa (marijuana) is a controlled substance in many parts of the world, the ability to track biogeographical origin of cannabis could provide law enforcement with investigative leads regarding its trade and distribution. Population substructure and inbreeding may cause cannabis plants to become more genetically related. This genetic relatedness can be helpful for intelligence purposes. Analysis of autosomal, chloroplast, and mitochondrial DNA allows for not only prediction of biogeographical origin of a plant but also discrimination between individual plants...
February 20, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29463913/impact-of-co-administration-of-oxycodone-and-smoked-cannabis-on-analgesia-and-abuse-liability
#16
Ziva D Cooper, Gillinder Bedi, Divya Ramesh, Rebecca Balter, Sandra D Comer, Margaret Haney
Cannabinoids combined with opioids produce synergistic antinociceptive effects, decreasing the lowest effective antinociceptive opioid dose (i.e., opioid-sparing effects) in laboratory animals. Although pain patients report greater analgesia when cannabis is used with opioids, no placebo-controlled studies have assessed the direct effects of opioids combined with cannabis in humans or the impact of the combination on abuse liability. This double-blind, placebo-controlled, within-subject study determined if cannabis enhances the analgesic effects of low dose oxycodone using a validated experimental model of pain and its effects on abuse liability...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29462320/air-quality-inside-police-drug-safes-and-drug-storage-areas
#17
Gregory S Doran, Ralph Deans, Carlo De Filippis, Chris Kostakis, Julia A Howitt
Storage of drug-based evidence inside sealed safes may allow chemical vapors to accumulate, creating concerns of drug exposure by inhalation, or the possibility of cross-contamination of drug evidence. Air samples were taken from inside eight drug safes and one small storage room at nine city and country police stations, as well as a large centralized drug evidence storage vault, in New South Wales (NSW), Australia. Sorbent tubes containing charcoal were used to determine whether any drug residues could be detected in the air, and to identify the types of chemicals present...
February 15, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29461948/case-251-nontraumatic-drug-associated-rhabdomyolysis-of-head-and-neck-muscles
#18
Alexandre Debelmas, Déborah Benchetrit, Damien Galanaud, Roman H Khonsari
History A 21-year-old man with a history of abuse of multiple drugs and mild cognitive impairment who initially underwent treatment for excited delirium developed respiratory arrest shortly after admission and was successfully resuscitated. Unenhanced computed tomography (CT) of the head and neck and contrast material-enhanced CT of the chest, abdomen, pelvis, and complete spine were performed shortly after the initial treatment. Head and neck magnetic resonance (MR) imaging was performed 24 hours after admission...
March 2018: Radiology
https://www.readbyqxmd.com/read/29461932/clinical-outcomes-from-a-10-week-follow-up-psychoeducational-programme-for-dual-diagnosis
#19
J Chilton, D Crone, P J Tyson
BACKGROUND: Dual diagnosis covers a broad spectrum of mental health and substance misuse conditions occurring concurrently (NICE, 2016). Its manifestation is complex and as such, the disorder is recognized as influencing adherence to prescribed medication, service engagement and has a worse prognosis than substance use and mental health conditions occurring independently. AIMS: To determine the effectiveness of psycho-educational group therapy on a sample of dual diagnosis patients...
February 20, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29461346/medical-cannabis-for-the-treatment-of-fibromyalgia
#20
George Habib, Suheil Artul
BACKGROUND: Fibromyalgia is a chronic pain syndrome, characterized by chronic musculoskeletal pain, fatigue, and mood disturbances. There are nearly no data on the effect of medical cannabis (MC) treatment on patients with fibromyalgia. METHODS: Data were obtained from the registries of 2 hospitals in Israel (Laniado Hospital and Nazareth Hospital) on patients with a diagnosis of fibromyalgia who were treated with MC. After obtaining patient consent, demographic, clinical, and laboratory parameters were documented...
February 14, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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