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https://www.readbyqxmd.com/read/29220642/substance-use-patterns-associated-with-recent-exposure-to-fentanyl-among-people-who-inject-drugs-in-vancouver-canada-a-cross-sectional-urine-toxicology-screening-study
#1
Kanna Hayashi, M-J Milloy, Mark Lysyshyn, Kora DeBeck, Ekaterina Nosova, Evan Wood, Thomas Kerr
INTRODUCTION: Vancouver, Canada is experiencing an opioid overdose crisis where fentanyl, a potent, synthetic opioid contaminating the illicit drug supply, has been detected in the majority of fatal overdose cases. Despite its growing presence throughout North America, few studies have characterized exposure to fentanyl among people who use illicit drugs (PWUD). We sought to identify the prevalence and correlates of fentanyl exposure among PWUD in Vancouver. METHODS: Data were derived from cohort studies of PWUD in Vancouver...
December 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29220602/an-observational-study-of-treatment-seeking-users-of-natural-opiates-from-india
#2
Arpit Parmar, Vaibhav Patil, Siddharth Sarkar, Ravindra Rao
BACKGROUND: The type of opioid used influences the severity and complications experienced. Natural opiates (opium and poppy husk) use is a socio-culturally accepted phenomenon reported in India. However, studies on their profile, quality of life, and addiction severity are limited. OBJECTIVES: The objective of this cross-sectional, observational study was to assess the socio-demographic profile, clinical profile, addiction severity, and quality of life of treatment-seeking natural opiate users...
December 8, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29218823/perspectives-of-cannabis-use-in-the-life-experience-of-men-with-schizophrenia
#3
Chris Wagstaff, Hermine Graham, Derek Farrell, Michael Larkin, Lloyd Tatham
Substance use amongst people with schizophrenia is well-established: up to 50% report using illicit substances. The occurrence of both conditions can also induce people to disengage from mental health services. The research question sought to understand, from the perspective of both service users and clinicians, cannabis use within the experience of people with schizophrenia. The transcripts of the seven participants and the two focus groups were analysed using interpretative phenomenological analysis. Service Users and Clinicians were recruited from Assertive outreach community-based teams...
December 8, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29218748/adolescent-non-drinkers-who-are-they-social-relations-school-performance-lifestyle-factors-and-health-behaviours
#4
Peter Larm, Cecilia Åslund, Jonas Raninen, Kent W Nilsson
INTRODUCTION AND AIMS: Traditionally, non-drinking adults or young adults have been associated with health deficits rather than health benefits. However, as the proportion of Swedish non-drinking adolescents has doubled since 2000, their health profiles are of interest. The aim of the present study is to examine whether social relations, school characteristics, lifestyle factors or health behaviours distinguish adolescent non-drinkers from adolescent drinkers, and if their health profiles have changed from 2004 to 2012...
December 7, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29218644/cardiovascular-complications-of-marijuana-and-related-substances-a-review
#5
REVIEW
Amitoj Singh, Sajeev Saluja, Akshat Kumar, Sahil Agrawal, Munveer Thind, Sudip Nanda, Jamshid Shirani
The recreational use of cannabis has sharply increased in recent years in parallel with its legalization and decriminalization in several countries. Commonly, the traditional cannabis has been replaced by potent synthetic cannabinoids and cannabimimetics in various forms. Despite overwhelming public perception of the safety of these substances, an increasing number of serious cardiovascular adverse events have been reported in temporal relation to recreational cannabis use. These have included sudden cardiac death, vascular (coronary, cerebral and peripheral) events, arrhythmias and stress cardiomyopathy among others...
December 7, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/29216571/negative-affectivity-as-a-mechanism-underlying-perceived-distress-tolerance-and-cannabis-use-problems-barriers-to-cessation-and-self-efficacy-for-quitting-among-urban-cannabis-users
#6
Kara Manning, Daniel J Paulus, Julianna B D Hogan, Julia D Buckner, Samantha G Farris, Michael J Zvolensky
Cannabis use rates continue to rise in the United States and currently cannabis is among the most widely used substances in the world. Cannabis use is associated with several mental health problems, low educational attainment, low income, and underemployment. The current study explored the tendency to experience negative affect (negative affectivity) as a factor accounting for the association between perceived distress tolerance and problems related to the use of cannabis. Participants included 203 urban adult daily cannabis users (29...
November 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29213247/mediating-effects-of-global-negative-effect-expectancies-on-the-association-between-problematic-cannabis-use-and-social-anxiety
#7
Maria Di Blasi, Paola Cavani, Laura Pavia, Crispino Tosto, Sabina La Grutta, Rosa Lo Baido, Cecilia Giordano, Adriano Schimmenti
The relationship between social anxiety (SA) and cannabis use among adolescents and young adults is a highly debated topic. In this cross-sectional study, we tested whether cannabis use expectancies mediated the association between SA and cannabis use severity in a sample of 343 young adults (74.3% male) who used cannabis. They completed self-report measures for the screening of problematic cannabis use (Cannabis Use Problems Identification Test) and SA symptoms (Social Interaction Anxiety Scale and Social Phobia Scale)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29211540/advertising-restrictions-on-cannabis-products-for-nonmedical-use-necessary-but-not-sufficient
#8
Jonathan P Caulkins
No abstract text is available yet for this article.
January 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29210141/extending-addiction-s-conflict-of-interest-policy-to-cover-the-emerging-cannabis-industry
#9
EDITORIAL
Keith Humphreys, Shane Darke, John Marsden, Robert West
No abstract text is available yet for this article.
December 5, 2017: Addiction
https://www.readbyqxmd.com/read/29209235/the-endless-trip-among-the-nps-users-psychopathology-and-psychopharmacology-in-the-hallucinogen-persisting-perception-disorder-a-systematic-review
#10
REVIEW
Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery, Fabrizio Schifano
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxymethamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases of HPPD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29207512/molecular-investigation-of-the-stem-snap-point-in-textile-hemp
#11
Marc Behr, Sylvain Legay, Jean-Francois Hausman, Stanley Lutts, Gea Guerriero
Fibre crops are important natural resources, as they sustainably provide bast fibres, an economically-valuable raw material used in the textile and biocomposite sectors. Among fibre crops, textile hemp (Cannabis sativa L.) is appreciated for its long and strong gelatinous bast fibres. The stem of fibre crops is a useful system for cell wall-oriented studies, because it shows a strong tissue polarity with a lignified inner core and a cellulosic hypolignified cortex, as well as a basipetal lignification gradient...
December 4, 2017: Genes
https://www.readbyqxmd.com/read/29207008/cannabis-use-and-hypomania-in-young-people-a-prospective-analysis
#12
Steven Marwaha, Catherine Winsper, Paul Bebbington, Daniel Smith
Background: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways. Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22-23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years...
November 28, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29206230/decisional-balance-and-processes-of-change-in-community-recruited-with-moderate-high-versus-mild-severity-of-cannabis-dependence
#13
Francisca López-Torrecillas, Eva María López-Quirantes, Antonio Maldonado, Natalia Albein-Urios, Mª Del Mar Rueda, Antonio Verdejo-Garcia
Decisional Balance and Processes of Change are generally addressed in motivational interventions for the treatment of cannabis use disorders. However, specific aspects of these multifaceted constructs, with greater relevance for severe cannabis users, need to be ascertained to enable better interventions. This study aimed to compare the different facets of decisional balance and processes of change between mild and severe cannabis users in a community-based sample of young undergraduates. Thirty-one severe cannabis users and 31 mild cannabis users, indicated with the Severity of Dependence Scale, were assessed using the Decisional Balance Questionnaire (DBQ) and the Processes of Change Questionnaire (PCQ)...
2017: PloS One
https://www.readbyqxmd.com/read/29204742/target-and-tissue-selectivity-prediction-by-integrated-mechanistic-pharmacokinetic-target-binding-and-quantitative-structure-activity-modeling
#14
Anna H C Vlot, Wilhelmus E A de Witte, Meindert Danhof, Piet H van der Graaf, Gerard J P van Westen, Elizabeth C M de Lange
Selectivity is an important attribute of effective and safe drugs, and prediction of in vivo target and tissue selectivity would likely improve drug development success rates. However, a lack of understanding of the underlying (pharmacological) mechanisms and availability of directly applicable predictive methods complicates the prediction of selectivity. We explore the value of combining physiologically based pharmacokinetic (PBPK) modeling with quantitative structure-activity relationship (QSAR) modeling to predict the influence of the target dissociation constant (K D) and the target dissociation rate constant on target and tissue selectivity...
December 4, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29203575/chronic-%C3%AE-9-thc-in-rhesus-monkeys-effects-on-cognitive-performance-and-dopamine-d2-d3-receptor-availability
#15
William S John, Thomas J Martin, Kiran K Solingapuram Sai, Susan H Nader, H D Gage, Akiva Mintz, Michael A Nader
Cannabis-related impairments to cognitive function may represent novel therapeutic targets for cannabis-use disorder, although the nature, persistence, and reversibility of those deficits remain unclear. Adult male rhesus monkeys (N=6) responded in the mornings on tasks designed to assess different cognitive domains using CANTAB touchscreens followed by responding maintained under a fixed-ratio (FR) 10 schedule of food presentation in different operant chambers. First, the acute effects of Δ9-tetrahydrocannabinol (THC; 0...
December 4, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29202510/extraction-method-and-analysis-of-cannabinoids-in-cannabis-olive-oil-preparations
#16
Antonella Casiraghi, Gabriella Roda, Eleonora Casagni, Cecilia Cristina, Umberto Maria Musazzi, Silvia Franzè, Paolo Rocco, Claudia Giuliani, Gelsomina Fico, Paola Minghetti, Veniero Gambaro
Recently, an increasing number of pharmacists had to supply medicinal products based on Cannabis sativa L. (Cannabaceae), prescribed by physicians to individual patients. Cannabis olive oil preparation is the first choice as a concentrated extract of cannabinoids, even though standardized operative conditions for obtaining it are still not available. In this work, the impact of temperature and extraction time on the concentration of active principles was studied to harmonize the different compounding methods, optimize the extraction process, and reduce the variability among preparations...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29201592/understanding-rates-of-marijuana-use-and-consequences-among-adolescents-in-a-changing-legal-landscape
#17
REVIEW
Elizabeth J D'Amico, Joan S Tucker, Eric R Pedersen, Regina A Shih
Purpose of Review: There is not one answer to address whether marijuana use has increased, decreased, or stayed the same given changes in state legalization of medical and non-medical marijuana in the USA. Recent Findings: Evidence suggests some health benefits for medical marijuana; however, initiation of marijuana use is a risk factor for developing problem cannabis use. Though use rates have remained stable over recent years, about one in three 10th graders report marijuana use, most adolescents do not view the drug as harmful, and over 650,000 youth aged 12 to 17 struggle with cannabis use disorder...
2017: Current Addiction Reports
https://www.readbyqxmd.com/read/29201551/investigation-of-the-comt-val158met-variant-association-with-age-of-onset-of-psychosis-adjusting-for-cannabis-use
#18
Rohit J Lodhi, Yabing Wang, David Rossolatos, Georgina MacIntyre, Alexandra Bowker, Candice Crocker, Hongyan Ren, Aleksandra Dimitrijevic, Darren A Bugbee, Alexandra Loverock, Brett Majeau, Sudhakar Sivapalan, Virginia M Newton, Philip Tibbo, Scot E Purdon, Katherine J Aitchison
Objective: COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. Methods: One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29200213/-the-medical-use-of-cannabis
#19
A Cura Della Redazione
No abstract text is available yet for this article.
October 2017: Assistenza Infermieristica e Ricerca: AIR
https://www.readbyqxmd.com/read/29199899/alcohol-and-drug-use-pain-and-psychiatric-symptoms-among-adults-seeking-outpatient-psychiatric-treatment-latent-class-patterns-and-relationship-to-health-status
#20
Danielle E Ramo, Amber L Bahorik, Kevin L Delucchi, Cynthia I Campbell, Derek D Satre
BACKGROUND: Substance use, psychiatric problems, and pain frequently co-occur, yet clinical profiles of treatment-seeking patients are poorly understood. To inform service and treatment planning, substance use and symptom patterns were examined in an outpatient psychiatry clinic, along with the relationship of these patterns to demographic characteristics and physical health. METHODS: Patients (N = 405; age M = 38; 69% White; 60% female) presenting for intake in a psychiatry outpatient clinic completed a computerized assessment of psychiatric problems, drinking, and drug use...
December 4, 2017: Journal of Psychoactive Drugs
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