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https://www.readbyqxmd.com/read/28214433/anxiety-and-cannabis-related-problem-severity-among-dually-diagnosed-outpatients-the-impact-of-false-safety-behaviors
#1
Julia D Buckner, Michael J Zvolensky, Anthony H Ecker, Emily R Jeffries, Austin W Lemke, Kimberlye E Dean, Michael S Businelle, Matthew W Gallagher
Cannabis use disorder (CUD) co-occurs with anxiety disorders at high rates. Little is known about the mechanisms linking CUD and anxiety disorders. One theoretically-driven perspective is that individuals with anxiety disorders may be more apt to use FSBs (i.e., behaviors that may be effective in decreasing anxiety in the short-term, but can maintain and even exacerbate anxiety in the long-term), which can perpetuate cannabis use despite cannabis-related problems. The present study tested whether FSB use explained the relation of anxiety symptom severity with cannabis quantity and related problems among 77 adults with CUD and comorbid anxiety disorders seeking outpatient CUD treatment...
February 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28213124/reciprocal-relationships-between-substance-use-and-disorders-and-suicidal-ideation-and-suicide-attempts-in-the-collaborative-study-of-the-genetics-of-alcoholism
#2
Arpana Agrawal, Rebecca Tillman, Richard A Grucza, Elliot C Nelson, Vivia V McCutcheon, Lauren Few, Kenneth R Conner, Michael T Lynskey, Danielle M Dick, Howard J Edenberg, Victor M Hesselbrock, John R Kramer, Samuel Kuperman, John I Nurnberger, Marc A Schuckit, Bernice Porjesz, Kathleen K Bucholz
BACKGROUND: Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders...
February 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28212939/cannabis-exacerbates-depressive-symptoms-in-rat-model-induced-by-reserpine
#3
Yasser A Khadrawy, Hussein G Sawie, Omar M E Abdel-Salam, Eman N Hosny
Cannabis sativa is one of the most widely recreational drugs and its use is more prevalent among depressed patients. Some studies reported that Cannabis has antidepressant effects while others showed increased depressive symptoms in Cannabis users. Therefore, the present study aims to investigate the effect of Cannabis extract on the depressive-like rats. Twenty four rats were divided into: control, rat model of depression induced by reserpine and depressive-like rats treated with Cannabis sativa extract (10mg/kg expressed as Δ9-tetrahydrocannabinol)...
February 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28212173/prediction-of-conversion-to-psychosis-in-individuals-with-an-at-risk-mental-state-a-brief-update-on-recent-developments
#4
Anita Riecher-Rössler, Erich Studerus
PURPOSE OF REVIEW: So far, only little more than one-third of individuals classified as being at-risk for psychosis have been shown to actually convert to frank psychosis during follow-up. There have therefore been enormous efforts to improve the accuracy of predicting this transition. We reviewed the most recent studies in the field with the aim to clarify whether accuracy of prediction has been improved by the different research endeavors and what could be done to further improve it, and/or what alternative goals research should pursue...
February 15, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28212013/high-time-to-assess-the-environmental-impacts-of-cannabis-cultivation
#5
K Ashworth, W Vizuete
No abstract text is available yet for this article.
February 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28210835/a-10-year-review-of-cannabis-exposure-in-children-under-3-years-of-age-do-we-need-a-more-global-approach
#6
Isabelle Claudet, Mathilde Le Breton, Camille Bréhin, Nicolas Franchitto
: Pediatricians working in an emergency environment are confronted with children admitted to emergency departments for intoxication on a daily basis. We carried out a retrospective cohort study of children admitted to a pediatric emergency department due to unintentional cannabis exposure over a 10-year period from 2004 to 2014. Twenty-nine children under the age of 3 were admitted with a positive cannabis urine test. Eighty-seven percent of intoxications occurred at the family home. Resin was the main form of ingested cannabis (69%)...
February 16, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28209284/recognizing-and-regulating-cannabis-as-a-temptation-good
#7
Jonathan P Caulkins
The U.S. appears to be on a path toward legalizing cannabis on the alcohol model, which is to say allowing for-profit corporations to produce, sell, and promote its use. Even after national legalization, it will take decades to observe the full effects on industry structure and behavior, or on use and misuse. However, we should not be surprised if after markets have matured and consumption patterns stabilized, legalization increases acute cannabis intoxication in the U.S. by 40 billion hours per year. This increase in use will be the most important cannabis-specific effect of legalization...
February 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28207408/evaluation-of-cannabinoids-concentration-and-stability-in-standardized-preparations-of-cannabis-tea-and-cannabis-oil-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#8
Roberta Pacifici, Emilia Marchei, Francesco Salvatore, Luca Guandalini, Francesco Paolo Busardò, Simona Pichini
BACKGROUND: Cannabis has been used since ancient times to relieve neuropathic pain, to lower intraocular pressure, to increase appetite and finally to decrease nausea and vomiting. The combination of the psychoactive cannabis alkaloid Δ9-tetrahydrocannabinol (THC) with the non-psychotropic alkaloids cannabidiol (CBD) and cannabinol (CBN) demonstrated a higher activity than THC alone. The Italian National Institute of Health sought to establish conditions and indications on how to correctly use nationally produced cannabis to guarantee therapeutic continuity in individuals treated with medical cannabis...
February 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28204792/problematic-use-of-prescription-opioids-and-medicinal-cannabis-among-patients-suffering-from-chronic-pain
#9
Daniel Feingold, Itay Goor-Aryeh, Silviu Bril, Yael Delayahu, Shaul Lev-Ran
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28202406/cannabis-cultivation-methodological-issues-for-obtaining-medical-grade-product
#10
REVIEW
Suman Chandra, Hemant Lata, Mahmoud A ElSohly, Larry A Walker, David Potter
As studies continue to reveal favorable findings for the use of cannabidiol in the management of childhood epilepsy syndromes and other disorders, best practices for the large-scale production of Cannabis are needed for timely product development and research purposes. The processes of two institutions with extensive experience in producing large-scale cannabidiol chemotype Cannabis crops-GW Pharmaceuticals and the University of Mississippi-are described, including breeding, indoor and outdoor growing, harvesting, and extraction methods...
February 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28197175/can-cannabinoids-be-a-potential-therapeutic-tool-in-amyotrophic-lateral-sclerosis
#11
REVIEW
Sabrina Giacoppo, Emanuela Mazzon
Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28196995/injection-drug-use-among-children-and-adolescents-in-india-ringing-the-alarm-bells
#12
Anju Dhawan, Raman Deep Pattanayak, Anita Chopra, Vinod Kumar Tikoo, Rajesh Kumar
INTRODUCTION: Injection drug use (IDU) is intricately linked to preventive aspects for human immunodeficiency virus from a public health perspective. No large-scale data are yet available for injectable drug use among children and adolescents in India, apart from few anecdotal reports. AIMS AND METHODS: The present paper reports on the profile and substance use pattern of 509 child IDU users, among a total sample of over 4000 children using substances across 100 sites from 27 states and 2 UTs in India...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28195831/psychometric-properties-of-the-turkish-versions-of-the-cannabis-use-problems-identi%C3%AF-cation-test-cupit-and-the-adult-cannabis-problems-questionnaire-cpq
#13
Cuneyt Evren, Hanife Yilmaz Cengel, Muge Bozkurt, Bilge Evren, Gokhan Umut, Ruken Agachanli
Cannabis and synthetic cannabinoids are widely used illicit substances in Turkey. The Cannabis Use Problems Identification Test (CUPIT) is a brief self-report screening instrument for detection of problematic cannabis use, whereas the Cannabis Problems Questionnaire (CPQ) is a measure for cannabis treatment outcome. The aim of this study was to evaluate the psychometric properties of the CUPIT and CPQ among Turkish male outpatients with cannabis (n = 52) and synthetic cannabinoid (n = 45) use disorder. Participants were evaluated with the CUPIT, the CPQ, and the Cannabis Withdrawal Scale (CWS)...
January 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28194818/data-on-cannabis-use-now-that-legalization-is-gaining-momentum
#14
Jan C van Ours
No abstract text is available yet for this article.
February 13, 2017: Addiction
https://www.readbyqxmd.com/read/28193575/applying-sewage-epidemiology-approach-to-estimate-illicit-drug-consumption-in-a-tropical-context-bias-related-to-sewage-temperature-and-ph
#15
Damien A Devault, Yves Lévi, Sara Karolak
Illicit drug consumption can be estimated from drug target residue (DTR) in wastewater, with the reliability of results being partly linked to DTR stability in the sewage network. However, wastewater temperature and pH drive the stability of molecules and, in this context, tropical conditions must be studied to specify the impact of residence time in the sewage network on DTR degradation. Warmth enhances biotic and abiotic processes such as degradation, leading to a decrease in oxygen content, and consequently, early diagenesis conditions in wastewater...
February 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28192758/ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-simple-and-simultaneous-quantification-of-cannabinoids
#16
Rohitash Jamwal, Ariel R Topletz, Bharat Ramratnam, Fatemeh Akhlaghi
Cannabis is used widely in the United States, both recreationally and for medical purposes. Current methods for analysis of cannabinoids in human biological specimens rely on complex extraction process and lengthy analysis time. We established a rapid and simple assay for quantification of Δ(9)-tetrahydrocannabinol (THC), cannabidiol (CBD), 11-hydroxy Δ(9)-tetrahydrocannabinol (11-OH THC) and 11-nor-9-carboxy-Δ(9)-tetrahydrocannbinol (THCCOOH) in human plasma by U-HPLC-MS/MS usingΔ9-tetrahydrocannabinol-D3 (THC-D3) as the internal standard...
February 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28192643/associations-between-substance-use-disorders-and-suicide-or-suicide-attempts-in-people-with-mental-illness-a-danish-nationwide-prospective-register-based-study-of-patients-diagnosed-with-schizophrenia-bipolar-disorder-unipolar-depression-or-personality-disorder
#17
Marie L D Østergaard, Merete Nordentoft, Carsten Hjorthøj
AIM: To estimate and test associations between substance use disorders (SUDs) and both completed suicides and suicide attempts in a population with severe mental illness. DESIGN: Register-based cohort study with adjusted Cox regression of substance use disorders as time-varying covariates. SETTING: Denmark. PARTICIPANTS: People born in Denmark since 1955 with a diagnosis of schizophrenia (n = 35,625), bipolar disorder (n = 9,279), depression (n = 72,530), or personality disorder (n = 63,958)...
February 13, 2017: Addiction
https://www.readbyqxmd.com/read/28191917/newborn-birth-weight-of-pregnant-women-on-methadone-or-buprenorphine-maintenance-treatment-a-national-contingency-management-approach-trial
#18
Einat Peles, Anat Sason, Shaul Schreiber, Miriam Adelson
BACKGROUND AND OBJECTIVES: Methadone maintenance treatment (MMT) is the gold standard for pregnant women with opioid use disorders. Still, low birth-weights were reported, in particular of mothers who became pregnant before admission to MMT. We studied whether an escalating incentive contingency-management approach may contribute to better newborn birth-weights. METHODS: A nationwide controlled randomized trial among all Israeli methadone/buprenorphine maintenance treatment (MBMT), newly or already in treatment pregnant women was performed...
February 13, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28191338/accelerated-burn-wound-closure-in-mice-with-a-new-formula-based-on-traditional-medicine
#19
Mehrnaz Mehrabani, Seyyed Mohsen Seyyedkazemi, Mohammad Hadi Nematollahi, Elham Jafari, Mitra Mehrabani, Mohammad Mehdipour, Zahra Sheikhshoaee, Ali Mandegary
BACKGROUND: A combination of the oils of sesame, hemp, wild pistachio, and walnut has been used for treatment of skin disorders, including wound burns, in some parts of Kerman, Iran. Evaluation of this remedy in the form of a pharmaceutical formulation in animal models can pave the way for its future application in wound burn healing in humans. OBJECTIVES: This experimental study investigated the healing potential of a new formula (NF) based on folk medicine from Iran for the treatment of third degree burns in mice...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28190698/therapeutic-effects-of-cannabinoids-in-animal-models-of-seizures-epilepsy-epileptogenesis-and-epilepsy-related-neuroprotection
#20
REVIEW
Evan C Rosenberg, Pabitra H Patra, Benjamin J Whalley
The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. In particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, prompting a particularly active area of preclinical research into the therapeutic potential of plant cannabinoids in epilepsy. Since that time, a large body of literature has accumulated describing the effects of several of the >100 individual plant cannabinoids in preclinical models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection...
February 9, 2017: Epilepsy & Behavior: E&B
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