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https://www.readbyqxmd.com/read/29656401/daily-patterns-of-marijuana-and-alcohol-co-use-among-individuals-with-alcohol-and-cannabis-use-disorders
#1
Jane Metrik, Rachel L Gunn, Kristina M Jackson, Alexander W Sokolovsky, Brian Borsari
BACKGROUND: The study aims were to examine daily associations between marijuana and alcohol use and the extent to which the association differs as a function of cannabis use disorder (CUD) and/or alcohol use disorder (AUD) diagnosis. METHODS: Timeline Followback interview data collected in a study of veterans (N=127) recruited from a Veterans Affairs hospital who reported at least one day of co-use of marijuana and alcohol in the past 180 days (22,860 observations)...
April 15, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29656267/a-naturalistic-examination-of-the-perceived-effects-of-cannabis-on-negative-affect
#2
Carrie Cuttler, Alexander Spradlin, Ryan J McLaughlin
BACKGROUND: Cannabis is commonly used to alleviate symptoms of negative affect. However, a paucity of research has examined the acute effects of cannabis on negative affect in everyday life. The current study provides a naturalistic account of perceived changes in symptoms of depression, anxiety, and stress as a function of dose and concentration of Δ9 tetrahydrocannabinol (THC) and cannabidiol (CBD). METHOD: Data from the app StrainprintTM (which provides medical cannabis users a means of tracking changes in symptoms as a function of different doses and chemotypes of cannabis) were analyzed using multilevel modeling...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29655919/endocannabinoid-system-in-systemic-lupus-erythematosus-first-evidence-for-a-deranged-2-arachidonoylglycerol-metabolism
#3
Luca Navarini, Tiziana Bisogno, Pamela Mozetic, Fabiana Piscitelli, Domenico Paolo Emanuele Margiotta, Fabio Basta, Antonella Afeltra, Mauro Maccarrone
The endocannabinoid (eCB) system plays a key role in many physiological and pathological conditions and its dysregulation has been described in several rheumatological and autoimmune diseases. Yet, its possible alteration in systemic lupus erythematosus (SLE) has never been investigated. Here, we aimed filling this gap in plasma and peripheral blood mononuclear cells (PBMCs) of patients with SLE and age- and sex- matched healthy subjects (HS). Liquid chromatography-mass spectrometry quantitation of eCB levels highlighted that plasma levels of 2-arachidonoylglycerol (2-AG) were significantly increased in SLE patients compared to HS (p = 0...
April 12, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29655375/association-between-traumatic-stress-load-psychopathology-and-cognition-in-the-philadelphia-neurodevelopmental-cohort
#4
Ran Barzilay, Monica E Calkins, Tyler M Moore, Daniel H Wolf, Theodore D Satterthwaite, J Cobb Scott, Jason D Jones, Tami D Benton, Ruben C Gur, Raquel E Gur
BACKGROUND: Traumatic stressors during childhood and adolescence are associated with psychopathology, mostly studied in the context of post-traumatic stress disorder (PTSD) and depression. We investigated broader associations of traumatic stress exposure with psychopathology and cognition in a youth community sample. METHODS: The Philadelphia Neurodevelopmental Cohort (N = 9498) is an investigation of clinical and neurobehavioral phenotypes in a diverse (56% Caucasian, 33% African American, 11% other) US youth community population (aged 8-21)...
April 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29653439/medical-cannabis-an-oxymoron-physicians-perceptions-of-medical-cannabis
#5
Yuval Zolotov, Simon Vulfsons, Dana Zarhin, Sharon Sznitman
BACKGROUND: Medical cannabis policies are changing in many places around the world, and physicians play a major role in the implementation of these policies. The aim of this study was to gain a deeper understanding of physicians' views on medical cannabis and its possible integration into their clinic, as well as to identify potential underlying factors that influence these perceptions. METHODS: Qualitative narrative analysis of in-depth interviews with twenty-four Israeli physicians from three specialties (pain medicine, oncology and family medicine)...
April 10, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29653350/relevance-of-treated-cocaine-users-retrospective-memory-of-first-cocaine-use
#6
Emily Karsinti, Kristel Piani, El Hedi Zerdazi, Uwe Maskos, Philippe Faure, Lucia Romo, Frank Bellivier, Georges Brousse, Jean Pierre Lépine, Vanessa Bloch, Florence Vorspan
Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29651709/-cannabinoid-therapy-in-practice
#7
REVIEW
T Rasche, D Emmert, C Stieber, M Mücke, R Conrad
BACKGROUND: In recent years, the media and scientists have shown increased interest in cannabis-based drugs. OBJECTIVES: Background information about cannabis-based drugs and their mechanism of action as well as discussion of possible applications as supportive therapy or in palliative medicine, respectively, are presented. MATERIALS AND METHODS: The recent literature was examined and evaluated. RESULTS: In many medical fields, we do not have sufficient evidence for the efficacy of cannabinoids...
April 12, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29648861/an-assessment-of-concurrent-cannabidiol-and-%C3%AE-%C3%A2-tetrahydrocannabinol-administration-in-place-aversion-and-taste-avoidance-conditioning
#8
Briana J Hempel, Matthew M Clasen, Katharine H Nelson, Claudia J Woloshchuk, Anthony L Riley
Rising interest in medical marijuana has prompted research into its phytocannabinoid constituents, particularly Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD). Coadministration of CBD with THC has been shown to modulate a number of THC's effects, including its negative stimulus properties (e.g., anxiety, paranoia, psychosis) in a clinical setting. The present series of experiments extended these analyses by examining the ability of CBD to impact the aversive effects of THC as assessed in a combined taste and place conditioning procedure...
April 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29648844/acceptability-of-nonabstinent-treatment-outcome-goals-among-addiction-treatment-providers-in-ukraine
#9
Alan K Davis, Tetiana Nickelsen, Robert A Zucker, Erin E Bonar, Maureen A Walton
We examined whether acceptability of nonabstinence treatment outcome goals varied as a function of a patient's severity of diagnosis (ICD-10 harmful use vs. dependence syndrome; World Health Organization, 1992), finality of outcome goal (intermediate vs. final), and type of substance (e.g., tobacco, alcohol, cannabis), among addiction treatment providers in Ukraine. We surveyed 44% of Ukrainian treatment providers (n = 446/1023; Mage = 40.4, SD = 8.6; Male = 67%; MYears Of Experience = 10.2, SD = 7.2). For tobacco use, most respondents (78%-93%) rated nonabstinence as acceptable, regardless of diagnostic severity or finality of outcome goal (i...
April 12, 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29642998/burden-of-arrhythmia-in-recreational-marijuana-users
#10
Rupak Desai, Upenkumar Patel, Abhishek Deshmukh, Rajesh Sachdeva, Gautam Kumar
Marijuana or Cannabis is extensively used as a recreational substance globally. Case reports have reported cardiac arrhythmias immediately following recreational marijuana use. However, the burden of arrhythmias in hospitalized marijuana users have not been evaluated through prospective or cross-sectional studies. Therefore, we planned to measure temporal trends of the frequency of arrhythmias in hospitalized marijuana users using National Inpatient Sample (NIS) database in the United States.
March 27, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29642878/the-problem-of-suicide-among-amerindians-in-camopi-trois-sauts-french-guiana-2008-2015
#11
Rémi Pacot, Basma Garmit, Marianne Pradem, Mathieu Nacher, Paul Brousse
BACKGROUND: Suicide within the Amerindian community of Camopi (1741 inhabitants) in French Guiana has been an increasing problem widely reported in the media leading the French Government to mandate a parliamentary mission to investigate the matter. The purpose of the study was to describe this phenomenon and identify factors associated with suicide attempts. METHODS: A retrospective observational study was conducted from the health centers' medical records. All suicide attempts and suicides committed between 2008 and 2015 by Amerindians living in Camopi and Trois Sauts were compiled...
April 11, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29642759/cannabis-use-and-knowledge-among-medical-students-at-the-university-of-the-free-state-bloemfontein-south-africa
#12
Roshini Jain, Ch Chiech Chang, Mpho A Koto, Alden N Geldenhuys, Richard J Nichol, Gina Joubert
OBJECTIVE: The study aimed to investigate the prevalence of cannabis use among undergraduate medical students of the University of the Free State (UFS), and the extent of their knowledge about the substance. METHOD: This cross-sectional study included five year groups of undergraduate medical students. A self-administered, anonymous questionnaire was used. RESULTS: Of the 643 medical students, 541 (84.1%) completed the questionnaire. In total, 161 (30...
April 11, 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29642723/impulsivity-traits-and-addiction-related-behaviors-in-youth
#13
Kristine Rømer Thomsen, Mette Buhl Callesen, Morten Hesse, Timo Lehmann Kvamme, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Valerie Voon
Background and aims Impulsivity is a risk factor for addictive behaviors. The UPPS-P impulsivity model has been associated with substance addiction and gambling disorder, but its role in other non-substance addiction-related behaviors is less understood. We sought to examine associations between UPPS-P impulsivity traits and indicators of multiple substance and non-substance addiction-related behaviors in youth with varying involvement in these behaviors. Methods Participants (N = 109, aged 16-26 years, 69% males) were selected from a national survey based on their level of externalizing problems to achieve a broad distribution of involvement in addiction-related behaviors...
April 12, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29630019/transfer-of-inhaled-cannabis-into-human-breast-milk
#14
Teresa Baker, Palika Datta, Kathleen Rewers-Felkins, Heather Thompson, Raja R Kallem, Thomas W Hale
OBJECTIVE: To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. METHODS: In this pilot pharmacokinetic study, breast milk samples were collected from mothers who regularly consumed cannabis, were 2-5 months postpartum, and exclusively breastfeeding their infants. Women were anonymously recruited for the study. After discontinuing cannabis for at least 24 hours, they were directed to obtain a baseline breast milk sample, then smoke a preweighed, analyzed, standardized strain of cannabis from one preselected dispensary, and collect breast milk samples at specific time points: 20 minutes and 1, 2, and 4 hours...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29628270/associations-between-adolescent-cannabis-use-and-brain-structure-in-psychosis
#15
Hila Abush, Subroto Ghose, Erin A Van Enkevort, Brett A Clementz, Godfrey D Pearlson, John A Sweeney, Matcheri S Keshavan, Carol A Tamminga, Elena I Ivleva
Associations between cannabis use and psychotic disorders suggest that cannabis may be a contributory risk factor in the neurobiology of psychosis. In this study, we examined brain structure characteristics, total and regional gray matter density (GMD), using Voxel Based Morphometry, in psychotic individuals, stratified by history of cannabis use (total n = 109). We also contrasted GMD estimates in individual diagnostic groups (schizophrenia/bipolar I disorder) with and without history of adolescent cannabis use (ACU)...
March 28, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29627821/global-scientific-production-on-illicit-drug-addiction-a-two-decade-analysis
#16
Malahat Khalili, Afarin Rahimi-Movaghar, Behrang Shadloo, Ramin Mojtabai, Karl Mann, Masoumeh Amin-Esmaeili
AIMS: Addiction science has made great progress in the past decades. We conducted a scientometric study in order to quantify the number of publications and the growth rate globally, regionally, and at country levels. METHODS: In October 2015, we searched the Scopus database using the general keywords of addiction or drug-use disorders combined with specific terms regarding 4 groups of illicit drugs - cannabis, opioids, cocaine, and other stimulants or hallucinogens...
April 6, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29627728/implementation-of-a-generic-liquid-chromatographic-method-development-workflow-application-to-the-analysis-of-phytocannabinoids-and-cannabis-sativa-extracts
#17
Szabolcs Fekete, Vida Sadat-Noorbakhsh, Cedric Schelling, Imre Molnár, Davy Guillarme, Serge Rudaz, Jean-Luc Veuthey
A generic liquid chromatographic method development workflow was developed and successfully applied to the analysis of phytocannabinoids and Cannabis sativa extracts. Our method development procedure consists in four steps: At the end, this method development workflow was performed in less than 4 days and minimizes the costs of the method development in liquid chromatography.
March 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29626744/opioids-in-oral-fluid-of-spanish-drivers
#18
Francisco Herrera-Gómez, Mercedes García-Mingo, Mónica Colás, Juan Carlos González-Luque, F Javier Álvarez
BACKGROUND: Driving under the influence of certain drugs is not allowed, and roadside drug testing is being considered an important tool for deterring driving under the influence of them. This study aimed to assess the presence and concentration of opioids, as well as their combined use with other drugs (laboratory confirmation after the on-road screening) in Spanish drivers between 2011 and 2016. METHODS: In Spain, mandatory roadside breath alcohol and oral fluid drug testing (screening) are carried out by the Traffic Police using Dräger Alcotest® 6810 device, and Dräger DrugTest® 5000, DrugWipe® , or Alere™ DDS® 2 Mobile Test System...
March 29, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29626630/reefer-madness-or-much-ado-about-nothing-cannabis-legalization-outcomes-among-young-adults-in-the-united-states
#19
Jamie E Parnes, Joey K Smith, Bradley T Conner
In 2012, Colorado became one of the first two U.S. States to legalize cannabis for recreational use for adults 21 and older. Given that cannabis use holds potential physical and mental health risks, particularly among adolescent users, concerns have grown regarding changes in use following this change in policy. Studies examining medical cannabis legalization have found inconsistent changes in cannabis use and prevalence of dependence following medical implementation. However, recreational legalization holds potential unique changes, such as increased availability and social acceptance, as well as decreased price and perceived harm of use...
April 4, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29625706/pharmaceutical-cognitive-doping-in-students-a-chimeric-way-to-get-a-head
#20
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the pressing demands for memorization, top-level performance, and peer competition create an environment favorable for pharmaceutical cognitive doping behavior. We aimed to describe recent practices and the benefit/risk ratio of such behavior and to discuss the issues at stake. The prevalence of pharmaceutical cognitive doping among students has been reported from 1.3% to 33% across studies, with variations depending on country and definition of pharmaceutical cognitive doping. The therapeutic classes most frequently cited as being diverted for doping purposes are psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
March 6, 2018: Thérapie
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