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https://www.readbyqxmd.com/read/29045928/factors-associated-with-alcohol-consumption-among-medical-cannabis-patients-with-chronic-pain
#1
Alan K Davis, Maureen A Walton, Kipling M Bohnert, Carrie Bourque, Mark A Ilgen
INTRODUCTION: Chronic pain is the most common reason for medical cannabis certification. Data regarding alcohol use and risky drinking among medical cannabis patients with pain is largely unknown. Therefore, we examined the prevalence and correlates of alcohol use and risky drinking in this population. METHODS: Participants completed surveys regarding demographics, pain-related variables, anxiety, cannabis use, and past six-month alcohol consumption. Alcohol use groups were defined using the AUDIT-C [i...
October 12, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29045919/altered-attentional-control-strategies-but-spared-executive-functioning-in-chronic-cannabis-users
#2
Amy T Nusbaum, Paul Whitney, Carrie Cuttler, Alexander Spradlin, John M Hinson, Ryan J McLaughlin
BACKGROUND: Cannabis use has increased rapidly in recent decades. The increase in cannabis use makes it important to understand the potential influence of chronic use on attentional control and other executive functions (EFs). Because cannabis is often used to reduce stress, and because stress can constrain attentional control and EFs, the primary goal of this study was to determine the joint effect of acute stress and chronic cannabis use on specific EFs. METHODS: Thirty-nine cannabis users and 40 non-users were assigned to either a stress or no stress version of the Maastricht Acute Stress Test...
October 12, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29045307/prevalence-of-antipsychotic-treated-patients-in-a-cohort-of-adult-addicted-patients
#3
Hélène Peyrière, Caroline Diot, Erika Nogue, Marie Verschave, Morgan Laure, Marie-Christine Picot, Pierre Petit, Hélène Donnadieu-Rigole, Yves Leglise
PURPOSE: The objective of this cross-sectional study was to describe and estimate the prevalence of antipsychotics (AP) in a cohort of addicted patients, and to compare the profiles of addictive patients receiving AP or not. METHODS: We included all adult patients seen at the addiction care center of Montpellier University Hospital, between January 1, 2015, and March 31, 2015. Demographic, clinical, and therapeutic data were collected from the patients' medical records...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045302/neurosteroid-levels-in-patients-with-bipolar-disorder-and-a-history-of-cannabis-use-disorders
#4
Brittany L Mason, Erin Van Enkevort, Francesca Filbey, Christine E Marx, John Park, Alyson Nakamura, Prabha Sunderajan, E Sherwood Brown
PURPOSE/BACKGROUND: In animal models, levels of the neurosteroid pregnenolone increase after tetrahydrocannabinol (THC) administration and pregnenolone appears to attenuate the brain effects of THC. Given these interactions between pregnenolone and THC, we evaluated baseline neurosteroid levels in participants with a history of a cannabis use disorders (CUDs). METHODS/PROCEDURES: Bipolar depressed participants were enrolled in a randomized placebo-controlled clinical trial to evaluate the efficacy of add-on pregnenolone for depression and before receiving pregnenolone or placebo...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045249/inhaled-loxapine-for-agitation-in-intoxicated-patients-a-case-series
#5
Carlos Roncero, Elena Ros-Cucurull, Raúl Felipe Palma-Álvarez, Alfonso Carlos Abad, Christian Fadeuilhe, Miquel Casas, Lara Grau-López
OBJECTIVES: Episodes of agitation are frequent in intoxicated patients who have a substance use disorder, a psychiatric disorder or both (dual diagnosis). For managing the agitation, it is necessary to act promptly in a safe environment and addressing any underlying etiology. Inhaled loxapine improves symptoms of agitation in adults with psychiatric disorders (eg, schizophrenia) within 10 minutes of administration. Recently, some reports have documented the usefulness of loxapine in dual diagnoses patients with agitation...
October 18, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29044778/the-impact-diverging-public-opinion-on-cannabis-and-tobacco-regulation-has-on-constructive-engagement-between-advocates
#6
Deborah Arnott
No abstract text is available yet for this article.
October 16, 2017: Addiction
https://www.readbyqxmd.com/read/29044015/-argentina-enacts-first-law-on-medical-use-of-the-cannabis-plant-history-and-perspectives
#7
Eduardo L De Vito
In the last few years, great expectations have risen in the society concerning the eventual therapeutic usefulness of compounds derived from the cannabis plant. It is well known that these compounds are being used in treating certain health conditions, either through medical prescription or self-administration. Extreme opinions range from believing that it is a harmful and dangerous drug to sustaining that it is a panacea. However, the sheer existence of an endocannabinoid system in the brain compels us to study its dimensions and derivations thoroughly...
2017: Medicina
https://www.readbyqxmd.com/read/29039260/medicinal-cannabis-bedrolite-substitution-therapy-in-inpatients-with-a-psychotic-disorder-and-a-comorbid-cannabis-use-disorder-a-case-series
#8
Regi Schipper, Mathilde Dekker, Lieuwe de Haan, Wim van den Brink
Cannabis use disorders are frequently comorbid in patients with a psychotic disorder and are associated with worse outcomes. To date there are no proven effective strategies to achieve cannabis abstinence in this population. An alternative for abstinence might be harm reduction, i.e. replacing the use of street cannabis with high tetrahydrocannabinol and low cannabidiol levels by medicinal cannabis variants with relatively low tetrahydrocannabinol and relatively high cannabidiol levels, thereby reducing the psychosis inducing effects of cannabis and enhancing the antipsychotic effects of cannabis...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29038721/gender-differences-in-substance-use-patterns-and-disorders-among-an-iranian-patient-sample-receiving-methadone-maintenance-treatment
#9
Amir Ghaderi, Maryam Motmaen, Iraj Abdi, Morad Rasouli-Azad
BACKGROUND: The current prevalence rate of substance abuse and dependence, represents an increasing trend of substance abuse and dependence among women, and the results of epidemiology studies indicate that substance use patterns are different between men and women. This study aimed to determine gender differences in substance use patterns and disorders among the patients undergoing methadone maintenance treatment. METHODS: This cross-sectional study was conducted throughout a specified time bracket ranging from September 2012 through March 2013 in Methadone Maintenance Treatment (MMT) clinics of Mashhad, Iran...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29038326/health-canada-to-warn-young-people-of-cannabis-risks-in-campaign
#10
Roger Collier
No abstract text is available yet for this article.
October 16, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29035279/cannabis-in-fat-high-hopes-to-treat-obesity
#11
Melody N Hawkins, Tamas L Horvath
Cannabinoid receptor type-1 (CB1s) is known to have a substantial impact on the regulation of energy metabolism via central and peripheral mechanisms. In this issue of the JCI, Ruiz de Azua and colleagues provide important insights into the regulation of adipocyte physiology by CB1. Mice with adipocyte-specific deletion of the CB1-encoding gene had an overall improved metabolic profile in addition to reduced body weight and total adiposity. These changes were associated with an increase in sympathetic tone of the adipose tissue and expansion of activated macrophages, both of which occurred prior to changes in body weight, lending support to a causal relationship between loss of CB1 in adipocytes and systemic metabolic changes...
October 16, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29034533/efficacy-tolerability-and-safety-of-cannabis-based-medicines-for-chronic-pain-management-an-overview-of-systematic-reviews
#12
REVIEW
W Häuser, F Petzke, M-A Fitzcharles
Medicinal cannabis has already entered mainstream medicine in some countries. This systematic review (SR) aimed at evaluating the efficacy, acceptability and safety of cannabis-based medicines for chronic pain management. Qualitative systematic review of SRs of randomized controlled trials with cannabis-based medicines for chronic pain management. The Cochrane databases of SRs, Database of Abstracts of Reviews of Effects and PubMed were searched for SR published in the period January 2009 to January 2017. Assessment of the methodological quality of SR was performed by the AMSTAR checklist...
October 15, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29034118/toward-a-patient-registry-for-cannabis-use-an-exploratory-study-of-patient-use-in-an-outpatient-health-care-clinic-in-oregon
#13
Kim A Hoffman, Javier Ponce Terashima, Dennis McCarty, John Muench
No abstract text is available yet for this article.
September 2017: World Medical & Health Policy
https://www.readbyqxmd.com/read/29031837/impaired-contrast-sensitivity-at-low-spatial-frequency-in-cannabis-users-with-early-onset
#14
Laurence Lalanne, Eglantine Ferrand-Devouge, Sebastien Kirchherr, Lucie Rauch, Estelle Koning, Claude Speeg, Vincent Laprevote, Anne Giersch
The regular use of cannabis generates pronounced cognitive disorders, especially in users who begin before the age of 15-16. However, less is known about the impact of regular cannabis on visual function, especially in the case of early onset. Cannabinoid receptors (CB1) are expressed in areas of the visual system, like the thalamus and primary cortex, which might originate sensory disorders. Hence, we measured contrast sensitivity (CS) in three groups, i.e. cannabis users with late onset of cannabis use (after 16 years old), cannabis users with early onset"...
October 11, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29031478/patterns-of-facial-trauma-before-and-after-legalization-of-marijuana-in-denver-colorado-a-joint-study-between-two-denver-hospitals
#15
Mofiyinfolu Sokoya, Justin Eagles, Tyler Okland, Dylan Coughlin, Hannah Dauber, Christopher Greenlee, Andrew A Winkler
INTRODUCTION: The effect of marijuana on human health has been studied extensively. Marijuana intoxication has been shown to affect performance, attention span, and reaction time. The public health relationship between trauma and cannabis use has also been studied, with mixed conclusions. In this report, the effect of marijuana legalization on many aspects of facial trauma at two hospitals in Denver, Colorado is examined. METHODS: A retrospective review of the electronic medical records was undertaken...
October 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29030980/beneficial-effect-of-alcohol-withdrawal-on-gut-permeability-and-microbial-translocation-in-patients-with-alcohol-use-disorder
#16
Hélène Donnadieu-Rigole, Nathalie Pansu, Thibault Mura, Stéphanie Pelletier, Régis Alarcon, Lucie Gamon, Pascal Perney, Florence Apparailly, Jean-Philippe Lavigne, Catherine Dunyach-Remy
BACKGROUND: The human intestinal microbiota exerts beneficial or harmful effects in several disorders. Many factors, including alcohol consumption, may influence its composition and trigger bacterial translocation. Excessive alcohol consumption increases gut permeability and translocation of endotoxin into peripheral circulation. Although plasma endotoxin concentrations have been measured often, quantitative changes following alcohol withdrawal have never been described in subjects with alcohol use disorder (AUD)...
October 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29030807/trends-in-cannabis-use-disorder-among-pregnant-women-in-the-u-s-1993-2014
#17
Yuyan Shi, Sheng Zhong
No abstract text is available yet for this article.
October 13, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29028562/common-and-differential-factors-associated-with-abstinence-and-poly-drug-use-among-australian-adolescents
#18
Simone Pettigrew, Michelle Jongenelis, David Lawrence, Wavne Rikkers
BACKGROUND: Social norms relating to youth substance use are changing. In Australia, alcohol use among adolescents has fallen dramatically and tobacco and cannabis use have also reduced, albeit more moderately. The aim of the present study was to identify (i) factors associated with compliance with recommendations for zero intake of alcohol, tobacco, and cannabis and (ii) factors associated with poly drug use (intake of all three substances). METHODS: As part of the Young Minds Matter Study, a self-report survey was administered to 1661 Australian adolescents aged 15-17 years...
October 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29028489/assessment-of-types-of-synthetic-cannabinoids-in-narcotic-cases-assessed-by-the-council-of-forensic-medicine-between-2011-2015-ankara-turkey
#19
Ersin Göl, İsmet Çok
Synthetic cannabinoids mimic the effects of cannabis and are the largest and fastest growing class of newly appearing designer drugs. Reports have revealed that various types of synthetic cannabinoids are mixed with herbal substances. The present study investigated the herbal substance cases involving synthetic cannabinoids in Ankara and nearby cities in Turkey. Data were collected from the reports of synthetic cannabinoids that were analyzed between January 01, 2011 and December 31, 2015 in the Ankara Narcotic Department of the Council of Forensic Medicine at the request of the judicial authorities...
October 4, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29025134/cannabis-dampens-the-effects-of-music-in-brain-regions-sensitive-to-reward-and-emotion
#20
Tom P Freeman, Rebecca A Pope, Matthew B Wall, James A Bisby, Maartje Luijten, Chandni Hindocha, Claire Mokrysz, Will Lawn, Abigail Moss, Michael A P Bloomfield, Celia J A Morgan, David J Nutt, H Valerie Curran
Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here we investigate the effects of cannabis on listening to music - a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol (CBD), which may offset cannabis-related harms. Methods: Across three sessions, sixteen cannabis users inhaled cannabis with CBD, cannabis without CBD, and placebo...
September 2, 2017: International Journal of Neuropsychopharmacology
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