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https://www.readbyqxmd.com/read/28730896/cannabinoid-hyperemesis-syndrome-potential-mechanisms-for-the-benefit-of-capsaicin-and-hot-water-hydrotherapy-in-treatment
#1
John R Richards, Jeff M Lapoint, Guillermo Burillo-Putze
INTRODUCTION: Cannabinoid hyperemesis syndrome is a clinical disorder that has become more prevalent with increasing use of cannabis and synthetic cannabinoids, and which is difficult to treat. Standard antiemetics commonly fail to alleviate the severe nausea and vomiting characteristic of the syndrome. Curiously, cannabinoid hyperemesis syndrome patients often report dramatic relief of symptoms with hot showers and baths, and topical capsaicin. OBJECTIVES: In this review, we detail the pharmacokinetics and pharmacodynamics of capsaicin and explore possible mechanisms for its beneficial effect, including activation of transient receptor potential vanilloid 1 and neurohumoral regulation...
July 21, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28729356/influence-of-childhood-trauma-on-diagnosis-and-substance-use-in-first-episode-psychosis
#2
S Tomassi, S Tosato, V Mondelli, C Faravelli, A Lasalvia, G Fioravanti, C Bonetto, A Fioritti, C Cremonese, R Lo Parrino, K De Santi, A Meneghelli, S Torresani, G De Girolamo, E Semrov, M Pratelli, D Cristofalo, M Ruggeri
BackgroundChildhood trauma has been significantly associated with first-episode psychosis, affective dysfunction and substance use.AimsTo test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use.MethodThe sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d. = 9.7).ResultsSevere sexual abuse was significantly associated with a diagnosis of affective psychosis (χ(2) = 4...
July 20, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28729196/legalization-of-cannabis-considerations-for-intervening-with-adolescent-consumers
#3
Denise D Walker
Eight states and the District of Columbia have legalized the recreational use of cannabis for adults and more are expected to follow suit. After alcohol, cannabis is the most commonly used drug by adolescents. Consumption of this drug during this developmental period poses unique risks. Therefore, attention must be paid both to how legalization affects adolescents and how tailored interventions can effectively address their needs for assistance. This commentary offers considerations for how legalization might be crafted so as to benefit adolescents...
July 17, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28728633/drinking-status-between-ages-50-and-55-for-men-from-the-san-diego-prospective-study-who-developed-dsm-iv-alcohol-abuse-or-dependence-in-prior-follow-ups
#4
Priscila Dib Gonçalves, Marc A Schuckit, Tom L Smith
OBJECTIVE: Although alcohol use disorders (AUDs) are prevalent among older individuals, few studies have examined the course and predictors of AUDs from their onset into the person's 50s. This study describes the AUD course from ages 50 to 55 in participants who developed AUDs according to criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), during the San Diego Prospective Study (SDPS). METHOD: Among the 397 university students in the SDPS who were followed about every 5 years from age 20 (before AUD onset), 165 developed AUDs, 156 of whom were interviewed at age 55...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28726525/working-memory-capacity-and-addiction-treatment-outcomes-in-adolescents
#5
Jon M Houck, Sarah W Feldstein Ewing
BACKGROUND: Brief addiction treatments including motivational interviewing (MI) have shown promise with adolescents, but the factors that influence treatment efficacy in this population remain unknown. One candidate is working memory, the ability to hold a fact or thought in mind. This is relevant, as in therapy, a client must maintain and manipulate ideas while working with a clinician. Working memory depends upon brain structures and functions that change markedly during neurodevelopment and that can be negatively impacted by substance use...
July 20, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28723278/a-case-of-cannabinoid-hyperemesis-syndrome-with-heliobacter-pylori-and-pre-eclampsia-during-pregnancy
#6
Madeline Manning Meurer, Kalyan Chakrala, Dinesh Gowda, Charles Burns, Randall Kelly, Natalia Schlabritz-Loutsevitch
The condition termed cannabinoid hyperemesis syndrome (CHS) was characterized a decade ago by Allen et al. and includes cyclic episodes of nausea and vomiting and the learned behavior of hot bathing in individuals with chronic cannabis abuse. During pregnancy, the differential diagnosis of this syndrome is challenging since it can be masked by typical symptoms of early pregnancy or by hyperemesis gravidarum, a complication of early pregnancy associated with excessive nausea and vomiting. We herein describe the case of a 21-year-old primigravida patient diagnosed with hyperemesis gravidarum at 6 weeks of gestation and with pre-eclampsia at 35 weeks...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28718398/comparative-study-of-nmr-spectral-profiling-for-the-characterization-and-authentication-of-cannabis
#7
Xinyi Wang, Peter de Harrington, Steven Baugh
For the authentication of botanical materials, it is difficult to obtain representative reference materials because botanicals vary significantly with respect to cultivation conditions. Chemical profiling of plant extracts or spectral fingerprinting can differentiate botanicals and group them by their chemical profiles. NMR spectroscopy yields a powerful and useful method for profiling plant extracts. Both 500 MHz (1)H and (1)H-(1)H correlation NMR spectroscopy coupled with pattern recognition were used to discriminate among Cannabis samples...
July 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28717382/neurological-soft-signs-in-tunisian-patients-with-first-episode-psychosis-and-relation-with-cannabis-use
#8
Ahmed Mhalla, Bochra Ben Mohamed, Christoph U Correll, Badii Amamou, Anouar Mechri, Lotfi Gaha
BACKGROUND: Neurological soft signs (NSS) are minor non-localizing neurological abnormalities that are conceptualized as neurodevelopmental markers that mediate the biological risk for psychosis. We aimed to explore the relationship between NSS and cannabis use, an environmental risk factor of psychosis. METHODS: This was a cross-sectional study in consecutively admitted patients hospitalized for first-episode psychosis. NSS were assessed by the NSS scale (23 items exploring motor coordination, motor integrative function, sensory integration, involuntary movements or posture, quality of lateralization)...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28716846/why-support-a-separate-medical-access-framework-for-cannabis
#9
Elizabeth A Cairns, Melanie E M Kelly
No abstract text is available yet for this article.
July 17, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28715777/regular-cannabis-and-alcohol-use-is-associated-with-resting-state-time-course-power-spectra-in-incarcerated-adolescents
#10
Sandra Thijssen, Barnaly Rashid, Shruti Gopal, Prashanth Nyalakanti, Vince D Calhoun, Kent A Kiehl
Cannabis and alcohol are believed to have widespread effects on the brain. Although adolescents are at increased risk for substance use, the adolescent brain may also be particularly vulnerable to the effects of drug exposure due to its rapid maturation. Here, we examined the association between cannabis and alcohol use duration and resting-state functional connectivity in a large sample of male juvenile delinquents. The present sample was drawn from the Southwest Advanced Neuroimaging Cohort, Youth sample, and from a youth detention facility in Wisconsin...
July 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28715729/consistent-association-between-hypnotics-sedatives-and-non-traffic-injuries-results-from-a-national-household-survey
#11
María Del Mar Martín-Rodríguez, José Pulido, Eladio Jiménez-Mejías, Juan Hoyos, Pablo Lardelli-Claret, Gregorio Barrio
AIM: To quantify the relationship between patterns of psychostimulants, hypnotics/sedatives and alcohol consumption and the frequency of unintentional non-traffic injuries (UNTIs) requiring medical assistant in Spain. METHODS: We carried out a cross sectional study using a randomized pooled sample from two household surveys on psychoactive drugs use (n=51,649 subjects aged 15-64 years). We estimated the magnitude of the association between the use of psychostimulants and hypnotics/sedatives in the last 12 months as well as alcohol consumption in the last 30days with the occurrence of UNTIs in the last 12 months (falls, knocks/bumps and cuts) by building several logistic regression models, which took into account the effect of sociodemographic characteristics and the use of other psychoactive drugs (including cannabis)...
July 14, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28711814/problem-alcohol-use-and-healthcare-utilization-among-persons-with-cannabis-use-disorder-in-the-united-states
#12
William S John, Li-Tzy Wu
BACKGROUND: The emergency department (ED) and hospital settings represent crucial opportunities for engaging treatment for cannabis use disorder (CUD). Thus, there is a need to identify factors associated with healthcare utilization among persons with CUD to improve screening and intervention approaches. Problematic alcohol use may be a salient risk factor. METHODS: Using data from the 2005-2013 National Surveys on Drug Use and Health, we determined factors, including different patterns of alcohol use, associated with past-year ED admission and inpatient hospitalization among persons aged 12 years or older meeting criteria for CUD in the past year (N=16,757)...
June 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28711812/bullying-involvement-and-adolescent-substance-use-a-multilevel-investigation-of-individual-and-neighbourhood-risk-factors
#13
Laura J Lambe, Wendy M Craig
BACKGROUND: Youth involved with school bullying are vulnerable to many negative outcomes, including substance use. Research has yet to examine how this vulnerability operates in the context of other individual and neighbourhood differences. The current study aimed to fill this gap by using multilevel modeling to investigate both the individual and neighbourhood risk factors associated with frequent drunkenness and frequent cannabis use among adolescents. METHODS: Data from the 2010 Canadian Health Behaviours in School-Aged Children (HBSC) survey were analyzed...
June 29, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28711226/-pain-cannabis-psychosis-a-logical-sequence
#14
Montserrat Perelló Alonso, Paul Ivanov
No abstract text is available yet for this article.
July 12, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28707583/cannabis-an-overview-of-its-adverse-acute-and-chronic-effects-and-their-implications
#15
Talitha C Ford, Amie C Hayley, Luke A Downey, Andrew C Parrott
In many communities, cannabis is perceived as a low-risk drug, leading to political lobbying to decriminalise its use. However, acute and chronic cannabis use has been shown to be harmful to several aspects of psychological and physical health, such as mood states, psychiatric outcomes, neurocognition, driving and general health. Furthermore, cannabis is highly addictive, and the adverse effects of withdrawal can lead to regular use. These in turn have adverse implications for public safety and health expenditure...
July 12, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/28705601/cannabis-use-attitudes-and-legal-status-in-the-u-s-a-review
#16
REVIEW
Hannah Carliner, Qiana L Brown, Aaron L Sarvet, Deborah S Hasin
Cannabis is widely used among adolescents and adults. In the U.S., marijuana laws have been changing, and Americans increasingly favor legalizing cannabis for medical and recreational uses. While some can use cannabis without harm, others experience adverse consequences. The objective of this review is to summarize information on the legal status of cannabis, perceptions regarding cannabis, prevalence and time trends in use and related adverse consequences, and evidence on the relationship of state medical (MML) and recreational (RML) marijuana laws to use and attitudes...
July 10, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28705600/poor-medication-adherence-and-risk-of-relapse-associated-with-continued-cannabis-use-in-patients-with-first-episode-psychosis-a-prospective-analysis
#17
Tabea Schoeler, Natalia Petros, Marta Di Forti, Ewa Klamerus, Enrico Foglia, Robin Murray, Sagnik Bhattacharyya
BACKGROUND: Cannabis use following the onset of first-episode psychosis has been linked to both increased risk of relapse and non-adherence with antipsychotic medication. Whether poor outcome associated with cannabis use is mediated through an adverse effect of cannabis on medication adherence is unclear. METHODS: In a prospective analysis of data acquired from four different adult inpatient and outpatient units of the South London and Maudsley Mental Health National Health Service Foundation Trust in London, UK, 245 patients were followed up for 2 years from the onset of first-episode psychosis...
July 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28705599/psychosis-relapse-medication-non-adherence-and-cannabis
#18
John A Engh, Jørgen G Bramness
No abstract text is available yet for this article.
July 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28704769/characterizing-marijuana-concentrate-users-a-web-based-survey
#19
Raminta Daniulaityte, Francois R Lamy, Monica Barratt, Ramzi W Nahhas, Silvia S Martins, Edward W Boyer, Amit Sheth, Robert G Carlson
AIMS: The study seeks to characterize marijuana concentrate users, describe reasons and patterns of use, perceived risk, and identify predictors of daily/near daily use. METHODS: An anonymous web-based survey was conducted (April-June 2016) with 673 US-based cannabis users recruited via the Bluelight.org web-forum and included questions about marijuana concentrate use, other drugs, and socio-demographics. Multivariable logistic regression analyses were conducted to identify characteristics associated with greater odds of lifetime and daily use of marijuana concentrates...
June 29, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28704167/-i-feel-like-i-ve-hit-the-bottom-and-have-no-idea-what-to-do-supportive-social-networking-on-reddit-for-individuals-with-a-desire-to-quit-cannabis-use
#20
Shaina J Sowles, Melissa J Krauss, Lewam Gebremedhn, Patricia A Cavazos-Rehg
BACKGROUND: Online communities can provide social support to those in need and can foster personal empowerment for individuals experiencing distress. This study examines the content of a Reddit community dedicated to the support of people trying to quit using cannabis, in order to develop an understanding of the type of social networking occurring on this subreddit (e.g. community). METHODS: A total of 100 Reddit posts and their replies (i.e. comments) were collected from the subreddit on June 12, 2015...
July 13, 2017: Substance Abuse
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