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https://www.readbyqxmd.com/read/27890949/p16-immunostaining-as-a-predictor-of-anal-and-cervical-dysplasia-in-women-attending-a-sexually-transmitted-infection-clinic
#1
Deepika Pandhi, Kavita Bisherwal, Archana Singal, Kiran Guleria, Kiran Mishra
BACKGROUND: Carcinogenesis caused by human papillomavirus (HPV) leads to over-expression of p16 protein. p16 may act as a marker of HPV integration with host genome and serve as a surrogate marker of HPV oncogenesis. MATERIALS AND METHODS: A single center study of 75 women (35 HIV-positive and 40 HIV-negative women) was conducted. Anal and cervical specimens were obtained for cytology and p16 immunostaining. RESULTS: The sensitivity of p16 to diagnose anal and cervical dysplasia was 50% and 58...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27879973/application-of-the-immunoscore-as-prognostic-tool-for-hepatocellular-carcinoma
#2
EDITORIAL
Annacarmen Petrizzo, Luigi Buonaguro
To date, the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) tumor, nodes, metastasis (TNM) classification represents the standard system for evaluation of prognosis in solid tumors. However, the clinical outcome can be significantly different in patients with the same TNM stage. Therefore, many efforts have been made aiming to define new prognostic parameters. Indeed, analyses conducted in large cohorts of colorectal cancer patients emphasized the prognostic value of tumor-infiltrating lymphocytes, leading to the development of a prognostic score referred to as "Immunoscore"...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27835889/immunoscore-encompassing-cd3-and-cd8-t-cell-densities-in-distant-metastasis-is-a-robust-prognostic-marker-for-advanced-colorectal-cancer
#3
Yoonjin Kwak, Jiwon Koh, Duck-Woo Kim, Sung-Bum Kang, Woo Ho Kim, Hye Seung Lee
BACKGROUND: The immunoscore (IS), an index based on the density of CD3+ and CD8+ tumor-infiltrating lymphocytes (TILs) in the tumor center (CT) and invasive margin (IM), has gained considerable attention as a prognostic marker. Tumor-associated macrophages (TAMs) have also been reported to have prognostic value. However, its clinical significance has not been fully clarified in patients with advanced CRC who present with distant metastases. METHODS: The density of CD3+, CD4+, CD8+, FOXP3+, CD68+, and CD163+ immune cells within CRC tissue procured from three sites-the primary CT, IM, and distant metastasis (DM)-was determined using immunohistochemistry and digital image analyzer (n=196)...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27816392/assessing-pdl-1-and-pd-1-in-non-small-cell-lung-cancer-a-novel-immunoscore-approach
#4
Erna-Elise Paulsen, Thomas K Kilvaer, Mehrdad Rakaee Khanehkenari, Samer Al-Saad, Sigurd M Hald, Sigve Andersen, Elin Richardsen, Nora Ness, Lill-Tove Busund, Roy M Bremnes, Tom Donnem
INTRODUCTION: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or its ligand, PD-L1, have gained momentum in the treatment of non-small cell lung cancer (NSCLC). However, their prognostic significance remains controversial. The present study evaluated the expression of PD-L1 and PD-1 and their potential role in an Immunoscore, supplementing the TNM classification of NSCLC. MATERIALS AND METHODS: Tissue microarrays constructed from tumor tissue samples from 2 cohorts of a total of 536 patients (University Hospital of North Norway, n = 285; Nordland Hospital, n = 251) with primary resected stage I to IIIA NSCLC...
October 5, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27708229/prognostic-effect-of-intratumoral-neutrophils-across-histological-subtypes-of-non-small-cell-lung-cancer
#5
Mehrdad Rakaee, Lill-Tove Busund, Erna-Elise Paulsen, Elin Richardsen, Samer Al-Saad, Sigve Andersen, Tom Donnem, Roy M Bremnes, Thomas K Kilvaer
Recent data indicate that tumor-associated neutrophils (TANs) serve a dual role in tumor progression and regression. CD66b is a neutrophil marker and has been associated with patient outcome in various cancers. However, its clinical impact in non-small cell lung cancer (NSCLC) remains controversial. 536 NSCLC patients, of which 172 harbored lymph node metastases, were included in this study. Tissue microarrays were constructed and multiplexed immunohistochemistry of CD66b, CD34 and pan-keratin was performed to evaluate the localization and quantity of CD66b+ TANs...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27660711/biomarkers-immune-monitoring-technology-primer-immunoscore%C3%A2-colon
#6
Fabienne Hermitte
No abstract text is available yet for this article.
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27650038/immunoscore-and-immunoprofiling-in-cancer-an-update-from-the-melanoma-and-immunotherapy-bridge-2015
#7
J Galon, B A Fox, C B Bifulco, G Masucci, T Rau, G Botti, F M Marincola, G Ciliberto, F Pages, P A Ascierto, M Capone
The fifth "Melanoma Bridge Meeting" took place in Naples, December 1-5th, 2015. The main topics discussed at this meeting were: Molecular and Immuno advances, Immunotherapies and Combination Therapies, Tumor Microenvironment and Biomarkers and Immunoscore. The natural history of cancer involves interactions between the tumor and the immune system of the host. The immune infiltration at the tumor site may be indicative of host response. Significant correlations were shown between the levels of immune cell infiltration in tumors and patient's clinical outcome...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27605872/immunotherapy-in-human-colorectal-cancer-challenges-and-prospective
#8
REVIEW
Xuan Sun, Jian Suo, Jun Yan
Human colorectal cancer (CRC) is the third most commonly diagnosed malignancies and the prognosis for patients with recurrent or metastatic disease is extremely poor. Although new chemotherapeutic regimen improves survival rates, therapy with better efficacy and less adverse effects is drastically needed. Immunotherapy has been investigated in human CRC for decades with limited success. However, recent developments of immunotherapy, particularly immune checkpoint inhibitor therapy, have achieved promising clinical benefits in many types of cancer and revived the hope for utilizing such therapy in human CRC...
July 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27599599/clinical-correlates-of-leiomyoma-estrogen-and-progesterone-receptors-among-nigerian-women
#9
Ibraheem O Awowole, Olufemiwa N Makinde, Olusegun O Badejoko, Ganiyat O Omoniyi-Esan, Aramide M Tijani, Kayode O Ajenifuja, Olabisi M Loto
OBJECTIVE: To compare the expression of estrogen receptor α (ERα) and progesterone receptor (PR) in myometrium and leiomyomata tissue, and to correlate their expression with symptoms of uterine leiomyomata. METHODS: In a cross-sectional study, intraoperative biopsy samples of leiomyomata and adjacent myometrial specimens were obtained from premenopausal women with uterine leiomyomata treated at a center in Nigeria between September 2013 and August 2014. Immunohistochemistry for ERα and PR expression was performed on the samples...
December 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27583028/strategies-to-modulate-the-immune-system-in-breast-cancer-checkpoint-inhibitors-and-beyond
#10
REVIEW
Cristina Migali, Monica Milano, Dario Trapani, Carmen Criscitiello, Angela Esposito, Marzia Locatelli, Ida Minchella, Giuseppe Curigliano
Is breast cancer (BC) immunogenic? Many data suggest that it is. Many observations demonstrated the prognostic role of tumor-infiltrating lymphocytes (TILs) in triple negative (TN) and human epidermal growth factor receptor 2 (HER-2)-positive BC. TNBCs are poorly differentiated tumors with high genetic instability and very high heterogeneity. This heterogeneity enhances the 'danger signals' and select clone variants that could be more antigenic or, in other words, that could more strongly stimulate a host immune antitumor response...
September 2016: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/27485137/analyses-of-pretherapy-peripheral-immunoscore-and-response-to-vaccine-therapy
#11
Benedetto Farsaci, Renee N Donahue, Italia Grenga, Lauren M Lepone, Peter S Kim, Brendan Dempsey, Janet C Siebert, Nuhad K Ibrahim, Ravi A Madan, Christopher R Heery, James L Gulley, Jeffrey Schlom
Tumor immunoscore analyses, especially for primary colorectal cancer and melanoma lesions, provide valuable prognostic information. Metastatic lesions of many carcinoma types, however, are often not easily accessible. We hypothesized that immune cells in peripheral blood may differ among individual patients with metastatic disease, which, in turn, may influence their response to immunotherapy. We thus analyzed immune cell subsets within peripheral blood mononuclear cells to determine if a "peripheral immunoscore" could have any prognostic significance for patients before receiving immunotherapy...
September 2, 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27384673/downregulation-of-the-neonatal-fc-receptor-expression-in-non-small-cell-lung-cancer-tissue-is-associated-with-a-poor-prognosis
#12
Emilie Dalloneau, Nadine Baroukh, Konstantinos Mavridis, Agnès Maillet, Fabien Gueugnon, Yves Courty, Agnès Petit, Thomas Kryza, Maguy Del Rio, Serge Guyetant, Diana Carolina Cadena Castaneda, Christine Dhommée, Christophe Arnoult, Andreas Scorilas, Valérie Gouilleux-Gruart, Nathalie Heuzé-Vourc'h
Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are required to indicate the prognosis, in particular within a specific stage, and help with the management of patients.Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-cancerous and NSCLC lung tissues and evaluated its prognostic value in overall survival for patient with NSCLC...
June 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27296405/-changes-in-the-cd8-density-of-tumor-infiltrating-lymphocytes-after-neoadjuvant-radiochemotherapy-in-patients-with-rectal-adenocarcinom
#13
D Buka, J Dvořák, V Sitorová, J Hátlová, I Richter, I Sirák
BACKGROUND: The goal of this study is to examine the effect of neoadjuvant radiochemotherapy on the density of CD8(+) tumor infiltrating lymphocytes (TILs) in endoscopical biopsies and resection specimens from patients with rectal adenocarcinoma before and after therapy. PATIENTS AND METHODS: In total, 53 patients with locally advanced rectal cancer were studied. RESULTS: The median density of CD8(+) TILs in pretreatment biopsies was 12 (1- 232) and that in surgical specimens after radiochemotherapy was 18 (1- 319)...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27141369/comparison-of-the-prognostic-value-of-measures-of-the-tumor-inflammatory-cell-infiltrate-and-tumor-associated-stroma-in-patients-with-primary-operable-colorectal-cancer
#14
J H Park, D C McMillan, J Edwards, P G Horgan, C S D Roxburgh
The aim of the present study was to compare the clinical utility of two measures of the inflammatory cell infiltrate - a H&E-based assessment of the generalized inflammatory cell infiltrate (the Klintrup-Mäkinen (KM) grade), and an immunohistochemistry-based assessment of combined CD3(+) and CD8(+) T-cell density (the "Immunoscore"), in conjunction with assessment of the tumor stroma percentage (TSP) in patients undergoing resection of stage I-III colorectal cancer (CRC). Two hundred and forty-six patients were identified from a prospectively maintained database of CRC resections in a single surgical unit...
March 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27136108/the-relationship-between-apoptotic-activity-and-prognostic-factors-in-neuroblastomas
#15
Sümeyye Ekmekci, Nur Olgun, Erdener Özer
OBJECTIVE: Prognostic parameters in determining risk groups for treatment in neuroblastoma are cellular differentiation, mitosis karyorrhexis index (MKI), N-myc amplification and age. However, additional prognosticators are still needed because patients can show unpredictable biological behavior. We aimed to study the prognostic significance of apoptotic activity in neuroblastomas. MATERIAL AND METHOD: Thirty-five primary neuroblastoma were evaluated. The data including stage, treatment protocol, metastatic disease, survival, N-myc status, age and prognostic categorization were obtained from the clinical records...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27121213/rational-bases-for-the-use-of-the-immunoscore-in-routine-clinical-settings-as-a-prognostic-and-predictive-biomarker-in-cancer-patients
#16
REVIEW
Amos Kirilovsky, Florence Marliot, Carine El Sissy, Nacilla Haicheur, Jérôme Galon, Franck Pagès
The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) tumor, nodes, metastasis (TNM) classification system based on tumor features is used for prognosis estimation and treatment recommendations in most cancers. However, the clinical outcome can vary significantly among patients within the same tumor stage and TNM classification does not predict response to therapy. Therefore, many efforts have been focused on the identification of new markers. Multiple tumor cell-based approaches have been proposed but very few have been translated into the clinic...
August 2016: International Immunology
https://www.readbyqxmd.com/read/27114170/distribution-of-superoxide-dismutase-1-and-glutathione-peroxidase-1-in-the-cyclic-canine-endometrium
#17
Celso Santos, Maria Dos Anjos Pires, Dario Santos, Rita Payan-Carreira
Superoxide dismutase (SOD) and glutathione peroxidase (GPx) are two important antioxidant enzymes involved in tissue homeostasis by protecting cells and tissues from an accumulation of reactive oxygen species. Information concerning antioxidant enzymes in the canine uterus is almost inexistent. This work intends to establish the pattern of distribution of SOD1 and GPx1 immunoreaction in canine endometrium throughout the estrous cycle, using 46 endometrium samples of healthy dogs representing different cycle stages (anestrus-10, proestrus-10, estrus-10, early diestrus-7, and diestrus-9)...
August 2016: Theriogenology
https://www.readbyqxmd.com/read/27073723/assessment-of-kallikrein-related-peptidase-5-klk5-protein-expression-in-tumor-tissue-of-advanced-ovarian-cancer-patients-by-immunohistochemistry-and-elisa-correlation-with-clinical-outcome
#18
Julia Dorn, Alexandra Yassouridis, Axel Walch, Eleftherios P Diamandis, Manfred Schmitt, Marion Kiechle, Ping Wang, Enken Drecoll, Barbara Schmalfeldt, Daniela Loessner, Matthias Kotzsch, Viktor Magdolen
Members of the human kallikrein-related peptidase (KLK) family, including KLK5, have been reported to play an important role in ovarian cancer progression. In the present study, we assessed KLK5 protein expression in ovarian cancer tissues by immunohistochemistry (IHC) and ELISA, and analyzed its association with clinicopathologic parameters and disease outcome in 95 patients with advanced ovarian cancer FIGO stage III/IV. KLK5 immunoexpression was evaluated in ovarian cancer tissue microarrays by IHC using a manual semiquantitative scoring system...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/26982367/integrative-analyses-of-colorectal-cancer-show-immunoscore-is-a-stronger-predictor-of-patient-survival-than-microsatellite-instability
#19
COMPARATIVE STUDY
Bernhard Mlecnik, Gabriela Bindea, Helen K Angell, Pauline Maby, Mihaela Angelova, David Tougeron, Sarah E Church, Lucie Lafontaine, Maria Fischer, Tessa Fredriksen, Maristella Sasso, Amélie M Bilocq, Amos Kirilovsky, Anna C Obenauf, Mohamad Hamieh, Anne Berger, Patrick Bruneval, Jean-Jacques Tuech, Jean-Christophe Sabourin, Florence Le Pessot, Jacques Mauillon, Arash Rafii, Pierre Laurent-Puig, Michael R Speicher, Zlatko Trajanoski, Pierre Michel, Richard Sesboüe, Thierry Frebourg, Franck Pagès, Viia Valge-Archer, Jean-Baptiste Latouche, Jérôme Galon
Microsatellite instability in colorectal cancer predicts favorable outcomes. However, the mechanistic relationship between microsatellite instability, tumor-infiltrating immune cells, Immunoscore, and their impact on patient survival remains to be elucidated. We found significant differences in mutational patterns, chromosomal instability, and gene expression that correlated with patient microsatellite instability status. A prominent immune gene expression was observed in microsatellite-instable (MSI) tumors, as well as in a subgroup of microsatellite-stable (MSS) tumors...
March 15, 2016: Immunity
https://www.readbyqxmd.com/read/26968206/intratumoral-cd3-and-cd8-t-cell-densities-associated-with-relapse-free-survival-in-hcc
#20
Andrew Gabrielson, Yunan Wu, Hongkun Wang, Jiji Jiang, Bhaskar Kallakury, Zoran Gatalica, Sandeep Reddy, David Kleiner, Thomas Fishbein, Lynt Johnson, Eddie Island, Rohit Satoskar, Filip Banovac, Reena Jha, Jaydeep Kachhela, Perry Feng, Tiger Zhang, Anteneh Tesfaye, Petra Prins, Christopher Loffredo, John Marshall, Louis Weiner, Michael Atkins, Aiwu Ruth He
Immune cells that infiltrate a tumor may be a prognostic factor for patients who have had surgically resected hepatocellular carcinoma (HCC). The density of intratumoral total (CD3(+)) and cytotoxic (CD8(+)) T lymphocytes was measured in the tumor interior and in the invasive margin of 65 stage I to IV HCC tissue specimens from a single cohort. Immune cell density in the interior and margin was converted to a binary score (0, low; 1, high), which was correlated with tumor recurrence and relapse-free survival (RFS)...
May 2016: Cancer Immunology Research
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