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https://www.readbyqxmd.com/read/28445292/prognostic-value-of-immunoscore-to-identify-mortality-outcomes-in-adults-with-hbv-related-primary-hepatocellular-carcinoma
#1
Qinwei Yao, Xuli Bao, Ran Xue, Hui Liu, Haixia Liu, Juan Li, Jinling Dong, Zhonghui Duan, Meixin Ren, Juan Zhao, Qi Song, Hongwei Yu, Yueke Zhu, Jun Lu, Qinghua Meng
This study aimed to determine if the immunoscore (IS) staging system would be a potential prognostic factor in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) in China.IS was performed in a consecutive cohort of HBV-HCC patients (n= 92). CD3+, CD8+, and CD45RO+ T cells were quantified by immunohistochemical analyses. The patients were stratified into 5 IS groups: I0, I1, I2, I3, I4 for every 2 cell phenotypes (IS1 (CD8/CD45RO, IS2 (CD3/CD8), and IS3 (CD3/CD45RO), respectively. ImagePro Plus software was used in the calculation of the paraffin-embedded tumor sections...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28439929/the-roles-of-autophagy-and-hypoxia-in-human-inflammatory-periapical-lesions
#2
H Y Huang, W C Wang, P Y Lin, C P Huang, C Y Chen, Y K Chen
AIM: To determine the expressions of hypoxia-related [hypoxia-inducible transcription factors (HIF)-1α, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), and phospho-adenosine monophosphate activated protein kinase (pAMPK)] and autophagy-related [microtubule-associated protein 1 light chain 3 (LC3), beclin-1 (BECN-1), autophagy-related gene (Atg)5-12, and p62] proteins in human inflammatory periapical lesions. METHODOLOGY: Fifteen samples of radicular cysts (RCs) and 21 periapical granulomas (PGs), combined with 17 healthy dental pulp tissues were examined...
April 25, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28427085/tumour-invasiveness-the-local-and-systemic-environment-and-the-basis-of-staging-systems-in-colorectal-cancer
#3
J H Park, H van Wyk, C S D Roxburgh, P G Horgan, J Edwards, D C McMillan
BACKGROUND: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer. METHODS: The tumour microenvironment was examined using measures of the inflammatory infiltrate (Klintrup-Makinen (KM) grade and Immunoscore), tumour stroma percentage (TSP) and tumour budding. The systemic inflammatory environment was examined using modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR)...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28422766/an-immunoscore-using-pd-l1-cd68-and-tumor-infiltrating-lymphocytes-tils-to-predict-response-to-neoadjuvant-chemotherapy-in-invasive-breast-cancer
#4
Lauren E McLemore, Murali Janakiram, Joseph Albanese, Nella Shapiro, Yungtai Lo, Xingxing Zang, Susan Fineberg
Response to neoadjuvant chemotherapy (NAC) in invasive breast cancer (IBC) is partly regulated by the immune microenvironment. We evaluated immune checkpoint PD-L1 expression, presence of CD68+ cells of macrophage/monocytic lineage and stromal tumor-infiltrating lymphocytes (TILs) in prechemotherapy biopsies and correlated with NAC response. We studied 76 cases of IBC. Prechemotherapy biopsies with >30% TILs were considered lymphocyte-rich IBC. We performed immunohistochemistry for PD-L1 and CD68. Prechemotherapy cores showing >1% PD-L1+ immune or tumor cells were considered positive...
April 18, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28412781/molecular-testing-to-optimize-and-personalize-decision-making-in-the-management-of-colorectal-cancer
#5
REVIEW
Marwan Al-Hajeili, Anthony F Shields, Jimmy J Hwang, Raymond C Wadlow, John L Marshall
Recent improvements in our understanding of the biology of colorectal cancer have led to the identification of several important prognostic and predictive markers of disease-associated risk and treatment response for the individual patient. Proper utilization of these biomarkers can enable physicians to tailor therapeutic strategies to maximize the likelihood of response and minimize treatment toxicity. In the management of colorectal cancer, tremendous progress has been made in the development of strategies for immune checkpoint inhibition; in refinement of agents and approaches used in targeted therapy; and in techniques for molecular subtyping of tumor samples that have identified patient subgroups with clinically relevant cellular differences potentially affecting clinical management and treatment outcome...
April 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28355940/immunohistochemical-analysis-of-egfr-and-hyaluronan-in-tongue-cancer-and-the-development-of-regional-recurrence-in-patients-initially-diagnosed-n0
#6
Eva Lindell Jonsson, Karin Nylander, Lars Hallén, Göran Laurell
OBJECTIVE: To investigate whether the extent of expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) in squamous cell carcinoma of the mobile tongue can predict the risk of cervical metastasis and survival. STUDY DESIGN: Retrospective histopathologic study. METHODS: Surgical specimens from 64 patients who had undergone surgery for squamous cell carcinoma of the mobile tongue were assessed using immunohistochemistry to investigate the expression of HA and EGFR in the primary tumours, and the data were then correlated to cervical metastasis and survival...
March 30, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28347886/immunohistochemical-expression-of-epithelial-cell-adhesion-molecule-epcam-in-mucoepidermoid-carcinoma-compared-to-normal-salivary-gland-tissues
#7
Noura M Kamal, Hend M Salem, Heba M Dahmoush
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor which displays biological, histological and clinical diversity thus representing a challenge for its diagnosis and management. Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein identified as a tumor specific antigen due to its frequent overexpression in the majority of epithelial carcinomas and its correlation with prognosis. It is considered to be a promising biomarker used as a therapeutic target already in ongoing clinical trials...
July 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28325116/stem-cell-markers-describe-a-transition-from-somatic-to-pluripotent-cell-states-in-a-rat-model-of-endometriosis
#8
Essam Rashad Othman, Fatma Yassine Meligy, Ayat Abdel-Rahman Sayed, Mohamed Ahmed El-Mokhtar, Abeer Mohamed Refaiy
OBJECTIVE: To study Thy1 as a fibroblast marker, SSEA1 as a marker of intermediate pluripotency, and Oct4 as a marker of established pluripotency in rat model of endometriosis. DESIGN: In vivo animal study. MATERIALS AND METHODS: Endometriosis was induced in 20 albino female rats through autologous transplantation of one uterine horn to mesentery of intestine. Other 20 rats had their horn removed without transplantation (controls). Rats were sacrificed 4 weeks after induction surgery...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28161000/-focus-on-the-immunoscore-and-its-potential-clinical-implications
#9
Carine El Sissy, Florence Marliot, Nacilla Haicheur, Amos Kirilovsky, Dragos Scripcariu, Christine Lagorce-Pagès, Jérôme Galon, Franck Pagès
The role of the immune response at the tumor site is now recognized as crucial in the clinical course of patients with cancer. The importance of the immune cell type, their functional orientation, their density and location within the tumor's regions (tumor/invasion margin) has recently been shown and were grouped together under the term "immune contexture". A strong infiltration by cytotoxic and memory T cells in a Th1-polarized tumor microenvironment appears to have a major prognosis impact. A test called Immunoscore taking into account these various parameters has been suggested to measure in a simple, reproducible and robust manner the intra- and peritumoral immune response...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28116480/inclusion-of-blimp-1-effector-regulatory-t-cells-improves-the-immunoscore-in-a-cohort-of-new-zealand-colorectal-cancer-patients-a-pilot-study
#10
Kirsten A Ward-Hartstonge, John L McCall, Timothy R McCulloch, Ann-Kristin Kamps, Adam Girardin, Erika Cretney, Fran M Munro, Roslyn A Kemp
Analysis of tumour-infiltrating T cells in colorectal cancer can predict disease-free survival. The Immunoscore, obtained by quantifying tumour-infiltrating CD3(+) and CD8(+) T cells, may improve current staging. Effector regulatory T cells are a potently suppressive subset in mice and, while present in human colorectal cancer, their role in patient outcome is unknown. Immunofluorescence was used to analyse immune cell infiltrates in patients with early (stage II) colorectal cancer with (n = 13) and without (n = 19) recurrent disease...
April 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28098570/preferential-localization-of-met-expression-at-the-invasion-front-and-in-spreading-cells-through-air-spaces-in-non-small-cell-lung-carcinomas
#11
Camille Lapère, Alexis B Cortot, Valérie Grégoire, Vincent Cockenpot, David Tulasne, Marie-Christine Copin
The involvement of the HGF/MET pathway in acquisition of an invasive phenotype in non-small cell lung carcinomas (NSCLCs) suggests that MET inhibitors might prove effective against these cancers, but clinical trials have yielded conflicting results. The aim of our study was to evaluate how intratumoral heterogeneity (ITH) of MET staining affects the determination of MET status for therapeutic purposes. We analyzed 64 NSCLC samples, including 33 adenocarcinomas (ADCs) and 31 squamous cell carcinomas (SCCs). We used immunohistochemistry to detect MET and phospho-MET on whole slides and determined the MET SP44 immunoscore and the H-score...
March 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28089104/immunoscore-predicts-gastric-cancer-postsurgical-outcome
#12
Mai Wang
No abstract text is available yet for this article.
January 6, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28059608/near-future-of-tumor-immunology-anticipating-resistance-mechanisms-to-immunotherapies-a-big-challenge-for-clinical-trials
#13
João Paulo Portela Catani, Rachel P Riechelmann, Sandy Adjemian, Bryan E Strauss
The success of immunotherapies brings hope for the future of cancer treatment. Even so, we are faced with a new challenge, that of understanding which patients will respond initially and, possibly, develop resistance. The examination of the immune profile, especially approaches related to the immunoscore, may foretell which tumors will have a positive initial response. Ideally, the mutation load would also be analyzed, helping to reveal tumor associated antigens that are predictive of an effective cytolytic attack...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28002059/immunoscore-signature-a-prognostic-and-predictive-tool-in-gastric-cancer
#14
Yuming Jiang, Qi Zhang, Yanfeng Hu, Tuanjie Li, Jiang Yu, Liying Zhao, Gengtai Ye, Haijun Deng, Tingyu Mou, Shirong Cai, Zhiwei Zhou, Hao Liu, Guihua Chen, Guoxin Li, Xiaolong Qi
OBJECTIVE: We postulated that the ImmunoScore (IS) could markedly improve the prediction of postsurgical survival and chemotherapeutic benefits in gastric cancer (GC). SUMMARY BACKGROUND DATA: A prediction model for GC patients was developed using data from 879 consecutive patients. METHODS: The expression of 27 immune features was detected in 251 specimens by using immunohistochemistry, and a 5-feature-based ISGC was then constructed using the LASSO Cox regression model...
December 20, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27890949/p16-immunostaining-as-a-predictor-of-anal-and-cervical-dysplasia-in-women-attending-a-sexually-transmitted-infection-clinic
#15
Deepika Pandhi, Kavita Bisherwal, Archana Singal, Kiran Guleria, Kiran Mishra
BACKGROUND: Carcinogenesis caused by human papillomavirus (HPV) leads to over-expression of p16 protein. p16 may act as a marker of HPV integration with host genome and serve as a surrogate marker of HPV oncogenesis. MATERIALS AND METHODS: A single center study of 75 women (35 HIV-positive and 40 HIV-negative women) was conducted. Anal and cervical specimens were obtained for cytology and p16 immunostaining. RESULTS: The sensitivity of p16 to diagnose anal and cervical dysplasia was 50% and 58...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27879973/application-of-the-immunoscore-as-prognostic-tool-for-hepatocellular-carcinoma
#16
EDITORIAL
Annacarmen Petrizzo, Luigi Buonaguro
To date, the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) tumor, nodes, metastasis (TNM) classification represents the standard system for evaluation of prognosis in solid tumors. However, the clinical outcome can be significantly different in patients with the same TNM stage. Therefore, many efforts have been made aiming to define new prognostic parameters. Indeed, analyses conducted in large cohorts of colorectal cancer patients emphasized the prognostic value of tumor-infiltrating lymphocytes, leading to the development of a prognostic score referred to as "Immunoscore"...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27835889/immunoscore-encompassing-cd3-and-cd8-t-cell-densities-in-distant-metastasis-is-a-robust-prognostic-marker-for-advanced-colorectal-cancer
#17
Yoonjin Kwak, Jiwon Koh, Duck-Woo Kim, Sung-Bum Kang, Woo Ho Kim, Hye Seung Lee
BACKGROUND: The immunoscore (IS), an index based on the density of CD3+ and CD8+ tumor-infiltrating lymphocytes (TILs) in the tumor center (CT) and invasive margin (IM), has gained considerable attention as a prognostic marker. Tumor-associated macrophages (TAMs) have also been reported to have prognostic value. However, its clinical significance has not been fully clarified in patients with advanced CRC who present with distant metastases. METHODS: The density of CD3+, CD4+, CD8+, FOXP3+, CD68+, and CD163+ immune cells within CRC tissue procured from three sites-the primary CT, IM, and distant metastasis (DM)-was determined using immunohistochemistry and digital image analyzer (n=196)...
December 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27816392/assessing-pdl-1-and-pd-1-in-non-small-cell-lung-cancer-a-novel-immunoscore-approach
#18
Erna-Elise Paulsen, Thomas K Kilvaer, Mehrdad Rakaee Khanehkenari, Samer Al-Saad, Sigurd M Hald, Sigve Andersen, Elin Richardsen, Nora Ness, Lill-Tove Busund, Roy M Bremnes, Tom Donnem
INTRODUCTION: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or its ligand, PD-L1, have gained momentum in the treatment of non-small cell lung cancer (NSCLC). However, their prognostic significance remains controversial. The present study evaluated the expression of PD-L1 and PD-1 and their potential role in an Immunoscore, supplementing the TNM classification of NSCLC. MATERIALS AND METHODS: Tissue microarrays constructed from tumor tissue samples from 2 cohorts of a total of 536 patients (University Hospital of North Norway, n = 285; Nordland Hospital, n = 251) with primary resected stage I to IIIA NSCLC...
March 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27708229/prognostic-effect-of-intratumoral-neutrophils-across-histological-subtypes-of-non-small-cell-lung-cancer
#19
Mehrdad Rakaee, Lill-Tove Busund, Erna-Elise Paulsen, Elin Richardsen, Samer Al-Saad, Sigve Andersen, Tom Donnem, Roy M Bremnes, Thomas K Kilvaer
Recent data indicate that tumor-associated neutrophils (TANs) serve a dual role in tumor progression and regression. CD66b is a neutrophil marker and has been associated with patient outcome in various cancers. However, its clinical impact in non-small cell lung cancer (NSCLC) remains controversial. 536 NSCLC patients, of which 172 harbored lymph node metastases, were included in this study. Tissue microarrays were constructed and multiplexed immunohistochemistry of CD66b, CD34 and pan-keratin was performed to evaluate the localization and quantity of CD66b+ TANs...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27660711/biomarkers-immune-monitoring-technology-primer-immunoscore%C3%A2-colon
#20
Fabienne Hermitte
No abstract text is available yet for this article.
2016: Journal for Immunotherapy of Cancer
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