keyword
https://read.qxmd.com/read/38531522/chitosan-thermogelation-and-cascade-mineralization-via-sequential-caco-3-incorporations-for-wound-care
#1
JOURNAL ARTICLE
Chengkun Liu, Menghan Li, Zhiyuan Liu, Zhuang Shi, Xiaoqiang Wang, Fang Huang
Physically crosslinked hydrogels have shown great potential as excellent and eco-friendly matrices for wound management. Herein, we demonstrate the development of a thermosensitive chitosan hydrogel system using CaCO3 as a gelling agent, followed by CaCO3 mineralization to fine-tune its properties. The chitosan hydrogel effectively gelled at 37 °C and above after an incubation period of at least 2 h, facilitated by the CaCO3 -mediated slow deprotonation of primary amine groups on chitosan polymers...
March 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38516476/thromboelastometric-analysis-of-the-correlation-between-burn-induced-coagulopathy-and-severity-of-burn-injury
#2
JOURNAL ARTICLE
Hiroyuki Koami, Yuichiro Sakamoto, Ayaka Matsuoka, Kota Shinada
Background In this study, we aimed to analyze the association between the burn index (BI) and burn-induced coagulopathy. Methods Adult burn patients transported to our emergency department who underwent rotational thromboelastometry (ROTEM) between April 1, 2013, and December 31, 2021, were enrolled in this study. The patients were categorized into two groups based on burn severity. Severe burns were defined as BI scores of > 15. Patient demographics, clinical variables of burns, standard laboratory test data, ROTEM data, and clinical outcomes of both groups were evaluated...
February 2024: Curēus
https://read.qxmd.com/read/38473772/research-into-new-molecular-mechanisms-in-thrombotic-diseases-paves-the-way-for-innovative-therapeutic-approaches
#3
REVIEW
Sara Sacchetti, Chiara Puricelli, Marco Mennuni, Valentina Zanotti, Luca Giacomini, Mara Giordano, Umberto Dianzani, Giuseppe Patti, Roberta Rolla
Thrombosis is a multifaceted process involving various molecular components, including the coagulation cascade, platelet activation, platelet-endothelial interaction, anticoagulant signaling pathways, inflammatory mediators, genetic factors and the involvement of various cells such as endothelial cells, platelets and leukocytes. A comprehensive understanding of the molecular signaling pathways and cell interactions that play a role in thrombosis is essential for the development of precise therapeutic strategies for the treatment and prevention of thrombotic diseases...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38456992/mining-phase-separation-related-diagnostic-biomarkers-for-endometriosis-through-wgcna-and-multiple-machine-learning-techniques-a-retrospective-and-nomogram-study
#4
JOURNAL ARTICLE
Qiuyi Liang, Shengmei Yang, Meiyi Mai, Xiurong Chen, Xiao Zhu
OBJECTIVE: The objective of this study was to investigate the role of phase separation-related genes in the development of endometriosis (EMs) and to identify potential characteristic genes associated with the condition. METHODS: We used GEO database data, including 74 non-endometriosis and 74 varying-degree EMs patients. Our approach involved identifying significant gene modules, exploring gene intersections, identifying core genes, and screening for potential EMs biomarkers using weighted gene co-expression network analysis (WGCNA) and various machine learning approaches...
March 8, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38430983/characterization-of-lncrna-and-mrna-profiles-in-ciliary-body-in-experimental-myopia
#5
JOURNAL ARTICLE
Shanshan Wu, Jiawen Hao, Dadong Guo, Zhongyu Ma, Qiuxin Wu, Ming Zhang, Hongsheng Bi
Currently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the development of myopia based on RNA sequencing...
February 29, 2024: Experimental Eye Research
https://read.qxmd.com/read/38426281/hemostasis-and-endothelial-functionality-the-double-face-of-coagulation-factors
#6
JOURNAL ARTICLE
Cristina Olgasi, Simone Assanelli, Alessia Cucci, Antonia Follenzi
Hemostasis is a sophisticated sequence of events aimed to repair vessel injury. This process occurs in combination with angiogenesis, which leads to new blood vessel formation helping in the wound repair and facilitating tissue healing. The fine mechanisms that regulate hemostasis and angiogenesis are well described, but for long time, coagulation factors (CFs) have been considered merely players in the coagulation cascade. However, several experimental evidences highlight the crucial functions of these CFs in regulating endothelial functionality, especially in the angiogenic process...
February 29, 2024: Haematologica
https://read.qxmd.com/read/38404937/factor-v-variants-in-bleeding-and-thrombosis
#7
JOURNAL ARTICLE
Adarsh K Mohapatra, Alice M Todaro, Elisabetta Castoldi
A state-of-the-art lecture titled "Factor V variants in bleeding and thrombosis" was presented at the International Society on Thrombosis and Haemostasis (ISTH) congress in 2023. Blood coagulation is a finely regulated cascade of enzymatic reactions culminating in thrombin formation and fibrin deposition at the site of injury. Factor V (FV) plays a central role in this process, as its activated form is an essential procoagulant cofactor in prothrombin activation. However, other molecular forms of FV act as anticoagulant cofactors of activated protein C and tissue factor pathway inhibitor α, respectively, thereby contributing to the regulation of coagulation...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38404266/-new-perspective-of-anticoagulation-in-intensive-care-unit-basic-and-clinical-advances-in-coagulation-factor-xii-and-xi-inhibitors
#8
REVIEW
Ruihua Wang, Zhiyun Yang, Shaolin Ma, Feng Zhu
Anticoagulation therapy stands as a key treatment for thrombotic diseases. The consequential bleeding risk tied to existing anticoagulation methods significantly impacts patient prognosis. In the intensive care unit (ICU), patients often necessitate organ support, leading to the inevitable placement of artificial devices in blood vessels, thereby requiring anticoagulation treatment to avert clot formation that might impede organ support. Nevertheless, these patients commonly encounter a heightened risk of bleeding...
January 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38400575/therapeutic-effects-and-molecular-mechanisms-of-natural-products-in-thrombosis
#9
REVIEW
Ming-Hao Yuan, Wen-Xiao Zhong, Yu-Lu Wang, Yu-Shi Liu, Jia-Wen Song, Yu-Rou Guo, Bin Zeng, Yi-Ping Guo, Li Guo
Thrombotic disorders, such as myocardial infarction and stroke, are the leading cause of death in the global population and have become a health problem worldwide. Drug therapy is one of the main antithrombotic strategies, but antithrombotic drugs are not completely safe, especially the risk of bleeding at therapeutic doses. Recently, natural products have received widespread interest due to their significant efficacy and high safety, and an increasing number of studies have demonstrated their antithrombotic activity...
February 23, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38399804/african-swine-fever-virus-i267l-is-a-hemorrhage-related-gene-based-on-transcriptome-analysis
#10
JOURNAL ARTICLE
Yuan Wen, Xianghan Duan, Jingjing Ren, Jing Zhang, Guiquan Guan, Yi Ru, Dan Li, Haixue Zheng
African swine fever (ASF) is an acute and severe disease transmitted among domestic pigs and wild boars. This disease is notorious for its high mortality rate and has caused great losses to the world's pig industry in the past few years. After infection, pigs can develop symptoms such as high fever, inflammation, and acute hemorrhage, finally leading to death. African swine fever virus (ASFV) is the causal agent of ASF; it is a large DNA virus with 150-200 genes. Elucidating the functions of each gene could provide insightful information for developing prevention and control methods...
February 17, 2024: Microorganisms
https://read.qxmd.com/read/38381277/kinin-kallikrein-system-new-perspectives-in-heart-failure
#11
REVIEW
Keivan Mohammadi, Davood Shafie, Newsha Ghomashi, Ali Abdolizadeh, Majid Sadeghpour
Heart failure (HF) is a pervasive clinical challenge characterized by compromised cardiac function and reduced quality of life. The kinin-kallikrein system (KSS), a multifaceted peptide cascade, has garnered substantial attention due to its potential role in HF. Through activation of B1 and/or B2 receptors and downstream signaling, kinins modulate various physiological processes, including inflammation, coagulation, pain, blood pressure control, and vascular permeability. Notably, aberrations in KKS components have been linked to HF risk...
February 21, 2024: Heart Failure Reviews
https://read.qxmd.com/read/38371826/new-pathophysiological-insights-from-serum-proteome-profiling-in-equine-atypical-myopathy
#12
JOURNAL ARTICLE
Caroline-J Kruse, Marc Dieu, Benoît Renaud, Anne-Christine François, David Stern, Catherine Demazy, Sophie Burteau, François Boemer, Tatiana Art, Patricia Renard, Dominique-M Votion
Equine atypical myopathy (AM) is a severe environmental intoxication linked to the ingestion of protoxins contained in seeds and seedlings of the sycamore maple ( Acer pseudoplatanus ) in Europe. The toxic metabolites cause a frequently fatal rhabdomyolysis syndrome in grazing horses. Since these toxic metabolites can also be present in cograzing horses, it is still unclear as to why, in a similar environmental context, some horses show signs of AM, whereas others remain clinically healthy. Label-free proteomic analyses on the serum of 26 diseased AM, 23 cograzers, and 11 control horses were performed to provide insights into biological processes and pathways...
February 13, 2024: ACS Omega
https://read.qxmd.com/read/38371524/identification-of-novel-biomarkers-and-immune-infiltration-characteristics-of-ischemic-stroke-based-on-comprehensive-bioinformatic-analysis-and-machine-learning
#13
JOURNAL ARTICLE
Shiyu Hu, Jingjing Cai, Sizhan Chen, Yang Wang, Lijie Ren
BACKGROUND: Ischemic stroke (IS) is one of most common causes of disability in adults worldwide. However, there is still a lack of effective and reliable diagnostic markers and therapeutic targets in IS. Furthermore, immune cell dysfunction plays an important role in the pathogenesis of IS. Hence, in-depth research on immune-related targets in progressive IS is urgently needed. METHODS: Expression profile data from patients with IS were downloaded from the Gene Expression Omnibus (GEO) database...
March 2024: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38325533/integrated-gene-co-expression-network-analysis-and-experimental-validation-revealed-potential-targets-of-human-urine-extract-cda-ii-in-treating-chronic-myeloid-leukemia
#14
JOURNAL ARTICLE
Lei Jiang, Haoyuan Hong, Shulin Xiang, Han Li, Jianyu Ji, Mei Lan, Bin Luo
BACKGROUND: Cell differentiation agent II (CDA-II) exhibits potent anti-proliferative and apoptosis-inducing properties against a variety of cancer cells. However, its mechanism of action in chronic myeloid leukemia (CML) remains unclear. METHODS: Cell counting Kit 8 (CCK-8) and flow cytometry were used to investigate the effects of CDA-II on the biological characteristics of K562 cells. Gene (mRNA and lncRNA) expression profiles were analyzed by bioinformatics to screen differentially expressed genes and to perform enrichment analysis...
February 5, 2024: Genomics
https://read.qxmd.com/read/38306010/factor%C3%A2-xi-inhibitors-a-new-horizon-in-anticoagulation-therapy
#15
REVIEW
João Presume, Jorge Ferreira, Regina Ribeiras
Anticoagulation therapy has undergone significant evolution, marked by the emergence of direct oral anticoagulants with distinct advantages. Despite these advancements, challenges persist in managing residual thrombotic and bleeding risks, particularly among vulnerable populations. The pursuit of alternative drugs has honed in on factor XI/XIa inhibitors. This comprehensive review delves into several key aspects regarding this new target: (i) the role of factor XI in the coagulation cascade; (ii) the genetic evidence and pathophysiologic rationale supporting factor XI inhibition as a therapeutic target; (iii) an exploration of the various types of factor XI/XIa inhibitors currently under investigation; (iv) potential applications of these medications, spanning thromboprophylaxis after orthopedic surgery, stroke prevention in atrial fibrillation, secondary prevention after acute coronary syndrome, non-cardioembolic stroke, thromboprophylaxis after foreign material implantation, end-stage renal disease, and patients with cancer; and (v) an overview of ongoing studies, recent findings, and the future trajectory of research into these drugs...
February 2, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38288779/functional-hemostatic-hydrogels-design-based-on-procoagulant-principles
#16
REVIEW
Boxiang Zhang, Min Wang, Heng Tian, Hang Cai, Siyu Wu, Simin Jiao, Jie Zhao, Yan Li, Huidong Zhou, Wenlai Guo, Wenrui Qu
Uncontrolled hemorrhage results in various complications and is currently the leading cause of death in the general population. Traditional hemostatic methods have drawbacks that may lead to ineffective hemostasis and even the risk of secondary injury. Therefore, there is an urgent need for more effective hemostatic techniques. Polymeric hemostatic materials, particularly hydrogels, are ideal due to their biocompatibility, flexibility, absorption, and versatility. Functional hemostatic hydrogels can enhance hemostasis by creating physical circumstances conducive to hemostasis or by directly interfering with the physiological processes of hemostasis...
January 30, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38257286/design-synthesis-and-evaluation-of-new-hybrid-derivatives-of-5-6-dihydro-4-h-pyrrolo-3-2-1-ij-quinolin-2-1-h-one-as-potential-dual-inhibitors-of-blood-coagulation-factors-xa-and-xia
#17
JOURNAL ARTICLE
Anna A Skoptsova, Athina Geronikaki, Nadezhda P Novichikhina, Alexey V Sulimov, Ivan S Ilin, Vladimir B Sulimov, Georgii A Bykov, Nadezhda A Podoplelova, Oleg V Pyankov, Khidmet S Shikhaliev
Cardiovascular diseases caused by blood coagulation system disorders are one of the leading causes of morbidity and mortality in the world. Research shows that blood clotting factors are involved in these thrombotic processes. Among them, factor Xa occupies a key position in the blood coagulation cascade. Another coagulation factor, XIa, is also a promising target because its inhibition can suppress thrombosis with a limited contribution to normal hemostasis. In this regard, the development of dual inhibitors as new generation anticoagulants is an urgent problem...
January 11, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38244305/advances-and-challenges-in-the-purification-of-recombinant-coagulation-factors-a-review
#18
REVIEW
Linling Yu, Dongmei Yang, Mengyao Chu, Yan Sun
Hemostasis is a complex process for the cessation of bleeding from an injured blood vessel, involving the interplay of 12 coagulation factors in the coagulation cascade with activated blood platelets and the vessel wall. Hence, the coagulation factors are important to control hemorrhage. However, the low abundance of many coagulation factors in human plasma proteins limited their production in therapeutic drugs and their clinical applications. With the development of modern biotechnology, commercially manufactured recombinant coagulation factors became available as hemostatic therapeutics, emerging a huge potential in pharmaceutical manufacturing market...
January 16, 2024: Journal of Chromatography. A
https://read.qxmd.com/read/38241814/new-anticoagulant-protein-from-medicinal-leech
#19
JOURNAL ARTICLE
Valentin A Manuvera, Daria D Kharlampieva, Pavel A Bobrovsky, Ekaterina N Grafskaia, Ksenia A Brovina, Vassili N Lazarev
The saliva of the medicinal leech contains various anticoagulants. Some of them, such as hirudin, are well known. However, it is reasonable to believe that not all anticoagulant proteins from medicinal leech saliva have been identified. We previously performed a comprehensive study of the transcriptome, genome, and proteome of leech salivary gland cells, which led to the discovery of several previously unknown hypothetical proteins that may have anticoagulant properties. Subsequently, we obtained a series of recombinant proteins and investigated their impact on coagulation in in vitro assays...
January 12, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38173173/-when-where-and-how-of-sars-cov-2-infection-affects-the-human-cardiovascular-system-a-narrative-review
#20
REVIEW
Nicholas G Kounis, Christos Gogos, Cesare de Gregorio, Ming-Yow Hung, Sophia N Kounis, Efthymios P Tsounis, Stelios F Assimakopoulos, Soheila Pourmasumi, Virginia Mplani, George Servos, Periklis Dousdampanis, Panagiotis Plotas, Marina A Michalaki, Grigorios Tsigkas, Gerasimos Grammatikopoulos, Dimitrios Velissaris, Ioanna Koniar
Coronavirus disease 2019 (COVID-19) is caused by the novel severe acute respiratory coronavirus-2 (SARS-CoV-2). Several explanations for the development of cardiovascular complications during and after acute COVID-19 infection have been hypothesized. The COVID-19 pandemic, caused by SARS-CoV-2, has emerged as one of the deadliest pandemics in modern history. The myocardial injury in COVID-19 patients has been associated with coronary spasm, microthrombi formation, plaque rupture, hypoxic injury, or cytokine storm, which have the same pathophysiology as the three clinical variants of Kounis syndrome...
January 3, 2024: Balkan Medical Journal
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