keyword
MENU ▼
Read by QxMD icon Read
search

Prostate cancer, bipolar

keyword
https://www.readbyqxmd.com/read/27749326/the-role-of-testosterone-in-the-treatment-of-castration-resistant-prostate-cancer
#1
Michael W Drazer, Walter M Stadler
Most men with metastatic prostate cancer who are treated with androgen deprivation therapy will eventually develop castration-resistant disease. In this review, we examine the molecular mechanisms that constitute castration resistance and how these processes may be exploited using testosterone-based therapies. We detail how the utilization of superphysiologic doses of testosterone at regular intervals, followed by a rapid clearance of testosterone through continued chemical castration, also known as bipolar androgen therapy, offers an especially promising therapeutic approach...
September 2016: Cancer Journal
https://www.readbyqxmd.com/read/27544575/prospective-randomized-trial-comparing-titanium-clips-to-bipolar-coagulation-in-sealing-lymphatic-vessels-during-pelvic-lymph-node-dissection-at-the-time-of-robot-assisted-radical-prostatectomy
#2
Pietro Grande, Giovanni Battista Di Pierro, Livio Mordasini, Matteo Ferrari, Christoph Würnschimmel, Hansjörg Danuser, Agostino Mattei
: Lymphocele is the most common complication after pelvic lymph node dissection (PLND). Over the years, various techniques have been introduced to prevent lymphocele, but no final conclusion can be drawn regarding the superiority of one technique over another. In this prospective study, 220 patients undergoing robot-assisted radical prostatectomy between 2012 and 2015 were randomized to receive titanium clips (group A, n=110) or bipolar coagulation (group B, n=110) to seal lymphatic vessels at the level of the femoral canal during extended PLND (ePLND)...
August 17, 2016: European Urology
https://www.readbyqxmd.com/read/27473672/growth-inhibition-by-testosterone-in-an-androgen-receptor-splice-variant-driven-prostate-cancer-model
#3
Daisuke Nakata, Kazuhide Nakayama, Tsuneo Masaki, Akira Tanaka, Masami Kusaka, Tatsuya Watanabe
BACKGROUND: Castration resistance creates a significant problem in the treatment of prostate cancer. Constitutively active splice variants of androgen receptor (AR) have emerged as drivers for resistance to androgen deprivation therapy, including the next-generation androgen-AR axis inhibitors abiraterone and enzalutamide. In this study, we describe the characteristics of a novel castration-resistant prostate cancer (CRPC) model, designated JDCaP-hr (hormone refractory). METHODS: JDCaP-hr was established from an androgen-dependent JDCaP xenograft model after surgical castration...
December 2016: Prostate
https://www.readbyqxmd.com/read/27338150/bipolar-androgen-therapy-for-men-with-androgen-ablation-na%C3%A3-ve-prostate-cancer-results-from-the-phase-ii-batman-study
#4
Michael T Schweizer, Hao Wang, Brandon Luber, Rosa Nadal, Avery Spitz, D Marc Rosen, Haiyi Cao, Emmanuel S Antonarakis, Mario A Eisenberger, Michael A Carducci, Channing Paller, Samuel R Denmeade
BACKGROUND: We have previously documented a paradoxical anti-tumor effect when castration-resistant prostate cancer patients were treated with intermittent, high-dose testosterone (i.e., Bipolar Androgen Therapy; BAT). Because, an adaptive increase in androgen receptor expression following chronic androgen deprivation therapy (ADT) may underlie this effect, we tested whether men with hormone-sensitive (HS) prostate cancer (PC) would also respond to BAT if given following a 6-month ADT lead-in...
September 2016: Prostate
https://www.readbyqxmd.com/read/27271795/characterization-of-fibroblast-free-cwr-r1ca-castration-recurrent-prostate-cancer-cell-line
#5
Mojgan Shourideh, Adam DePriest, James L Mohler, Elizabeth M Wilson, Shahriar Koochekpour
BACKGROUND: The previously established CWR-R1 cell line has been used as an in vitro model representing castration-recurrent prostate cancer. Microscopic observation of subconfluent cells demonstrated two distinct cellular morphologies: polygonal closely aggregated epithelial cells surrounded by bipolar fibroblastic cells with long processes. This study sought to establish and characterize a fibroblast-free derivative of the CWR-R1 cell line. METHODS: The CWR-R1ca cell line was established from CWR-R1 cells by removing fibroblasts using multiple cycles of short-term trypsinization, cloning, and pooling single-cell colonies...
September 2016: Prostate
https://www.readbyqxmd.com/read/27166396/testosterone-in-androgen-receptor-signaling-and-dna-repair-enemy-or-frenemy
#6
Melvin Lee Kiang Chua, Robert G Bristow
Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy. Clin Cancer Res; 22(13); 3124-6. ©2016 AACRSee related article by Hedayati et al...
July 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26954621/phase-i-and-ii-therapies-targeting-the-androgen-receptor-for-the-treatment-of-castration-resistant-prostate-cancer
#7
Athanasios Dellis, Athanasios G Papatsoris
INTRODUCTION: Prostate cancer is the most common cancer in elderly males. Regardless of the initial hormonal treatment in metastatic disease, a significant proportion of patients develop castration resistant prostate cancer (CRPC). A better understanding of the molecular mechanisms behind castration resistance has led to the approval of oral medications such as abiraterone acetate and enzalutamide. Relevant research is accelerated with numerous agents being tested for the management of CRPC...
June 2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/26872373/darpp-32-from-neurotransmission-to-cancer
#8
REVIEW
Abbes Belkhiri, Shoumin Zhu, Wael El-Rifai
Dopamine and cAMP-regulated phosphoprotein Mr 32,000 (DARPP-32), also known as phosphoprotein phosphatase-1 regulatory subunit 1B (PPP1R1B), was initially discovered as a substrate of dopamine-activated protein kinase A (PKA) in the neostriatum in the brain. While phosphorylation at Thr-34 by PKA converts DARPP-32 into a potent inhibitor of protein phosphatase 1 (PP1), phosphorylation at Thr-75 transforms DARPP-32 into an inhibitor of PKA. Through regulation of DARPP-32 phosphorylation and modulation of protein phosphatase and kinase activities, DARPP-32 plays a critical role in mediating the biochemical, electrophysiological, and behavioral effects controlled by dopamine and other neurotransmitters in response to drugs of abuse and psychostimulants...
April 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/26793880/-the-mechanisms-of-prostate-cancer-progression-through-androgen-receptor
#9
Yusuke Goto, Shinichi Sakamoto, Tomohiko Ichikawa
Androgen receptor(AR) has a critical role in prostate cancer(PCa) progression and targeting AR axis signaling by androgen deprivation therapy is a standard treatment for advanced PCa. Recently, the role of AR even in castration-resistant PCa(CRPC) is well recognized and emerging evidence suggests survival advantages of treatment by targeting AR in CRPC. This review outlines AR functions that contribute to PCa progression, AR structural alterations and AR activation via intracrine, co-factors, and kinase pathways in CRPC...
January 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/26622483/bipolar-button-electrode-plasma-vaporization-of-the-prostate-an-effective-option-for-patients-with-post-brachytherapy-retention
#10
Yiwei Lin, Ben Liu, Liping Xie
Urinary retention is a common urinary complication following brachytherapy for prostate cancer. When conservative therapy has failed, surgical intervention, such as transurethral resection of the prostate (TURP), is performed. In the present case, it was found that conventional bipolar TURP was an inappropriate choice of therapy, since the electrical loop could easily rupture and discharge sparks when encountering the seeds intraoperatively; however, bipolar button-electrode plasma vaporization of the prostate was proven to be a much safer technique...
October 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26567111/tumor-associated-endo180-requires-stromal-derived-lox-to-promote-metastatic-prostate-cancer-cell-migration-on-human-ecm-surfaces
#11
Matthew P Caley, Helen King, Neel Shah, Kai Wang, Mercedes Rodriguez-Teja, Julian H Gronau, Jonathan Waxman, Justin Sturge
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can adopt different migratory modes in response to their microenvironment. Here we present a model that uses human stromal cell-derived matrices to demonstrate that plasticity in tumor cell movement is controlled by the tumor-associated collagen receptor Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) and the crosslinking of collagen fibers by stromal-derived lysyl oxidase (LOX)...
February 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/26487340/does-the-presence-of-a-major-psychiatric-disorder-affect-tolerance-and-outcomes-in-men-with-prostate-cancer-receiving-radiation-therapy
#12
Joseph J Safdieh, David Schwartz, Justin Rineer, Joseph P Weiner, Andrew Wong, David Schreiber
Prior studies have suggested that men with prostate cancer and psychiatric disorders (+Psy) have worse outcomes compared with those without (-Psy), particularly due to delayed diagnosis or reduced access to definitive treatment. In the current study, the toxicity and outcomes of men who were primarily diagnosed through prostate-specific antigen screening and who underwent definitive treatment with external beam radiation was investigated. The charts of 469 men diagnosed with prostate cancer from 2003 to 2010 were reviewed...
October 20, 2015: American Journal of Men's Health
https://www.readbyqxmd.com/read/26282355/re-effect-of-bipolar-androgen-therapy-for-asymptomatic-men-with-castration-resistant-prostate-cancer-results-from-a-pilot-clinical-study
#13
COMMENT
Nathan Wilken, Jason M Scovell, Ranjith Ramasamy
No abstract text is available yet for this article.
September 2015: European Urology
https://www.readbyqxmd.com/read/25814159/from-bench-to-bedside-bipolar-androgen-therapy-in-a-pilot-clinical-study
#14
COMMENT
Qing Zhang, Phillip J Gray
Prostate cancer remains a leading cause of cancer death in Europe and the United States and is an emerging problem in Asia despite significant improvements in available treatments over the last few decades. Androgen deprivation therapy (ADT) has been the core treatment of advance-staged disease since the discovery of prostate cancer's androgen dependence in 1941 by Huggins et al. [1] Options for initial medical treatment include gonadotropin-releasing hormone analogues such as leuprolide (LHRH agonist) and degarelix (LHRH antagonist) and androgen receptor (AR) binding agents such as bicalutamide...
September 2015: Asian Journal of Andrology
https://www.readbyqxmd.com/read/25568070/effect-of-bipolar-androgen-therapy-for-asymptomatic-men-with-castration-resistant-prostate-cancer-results-from-a-pilot-clinical-study
#15
Michael T Schweizer, Emmanuel S Antonarakis, Hao Wang, A Seun Ajiboye, Avery Spitz, Haiyi Cao, Jun Luo, Michael C Haffner, Srinivasan Yegnasubramanian, Michael A Carducci, Mario A Eisenberger, John T Isaacs, Samuel R Denmeade
Targeting androgen receptor (AR) axis signaling by disrupting androgen-AR interactions remains the primary treatment for metastatic prostate cancer. Unfortunately, all men develop resistance to primary castrating therapy and secondary androgen deprivation therapies (ADTs). Resistance develops in part because castration-resistant prostate cancer (CRPC) cells adaptively up-regulate AR levels through overexpression, amplification, and expression of ligand-independent variants in response to chronic exposure to a low-testosterone environment...
January 7, 2015: Science Translational Medicine
https://www.readbyqxmd.com/read/25457383/visual-electrochemiluminescence-detection-of-cancer-biomarkers-on-a-closed-bipolar-electrode-array-chip
#16
Mei-Sheng Wu, Zhen Liu, Hai-Wei Shi, Hong-Yuan Chen, Jing-Juan Xu
This paper describes a novel electrochemiluminescence (ECL) imaging platform for simultaneous detection of cancer biomarkers based on a closed bipolar electrode (BPE) array. It consists of two separated channel arrays: detection channel array and sensing channel array, which are connected by a group of parallel ITO BPEs on a glass substrate. Besides, two parallel ITO strips are fabricated at the two sides of BPE array and employed as driving electrodes. After Au films are electrochemically deposited on the cathodes of the BPE array, nanobioprobes including biorecognition elements (aptamer or antibody) and a novel electrochemical tag, which is synthesized by doping thionine in silica nanoparticles (Th@SiO2 NPs), are introduced into the cathodes by immunoreaction or DNA hybridization...
January 6, 2015: Analytical Chemistry
https://www.readbyqxmd.com/read/25335499/the-association-between-prostate-cancer-and-mood-disorders-a-nationwide-population-based-study-in-taiwan
#17
Pan-Ming Chen, San-Chi Chen, Chia-Jen Liu, Man-Hsin Hung, Chia-Fen Tsai, Yu-Wen Hu, Mu-Hong Chen, Cheng-Che Shen, Tung-Ping Su, Chiu-Mei Yeh, Ti Lu, Tzeng-Ji Chen, Li-Yu Hu
BACKGROUND: This study identified possible risk factors for newly diagnosed mood disorders, including depressive and bipolar disorders, in prostate cancer patients. METHODS: From 2000 to 2006, two cohorts were evaluated on the occurrence of mood disorder diagnosis and treatment. For the first cohort, data of patients diagnosed with prostate cancer was obtained from the Taiwan National Health Insurance (NHI) Research Database. As the second cohort, a cancer-free comparison group was matched for age, comorbidities, geographic region, and socioeconomic status...
March 2015: International Psychogeriatrics
https://www.readbyqxmd.com/read/25334706/neck-swelling-and-prostate-cancer-can-they-be-related
#18
Muhammad Khawar, Minh Phan, Tauseef Ali
SESSION TITLE: Cancer Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Prostate adenocarcinoma commonly metastasizes to the axial skeleton, lungs, and liver. Isolated metastasis to the thyroid gland is rare. We describe a patient with a sudden onset of neck swelling accompanied by clinical features of Superior Vena Cava Syndrome (SVCS), who later was found to have thyroid metastasis from prostate adenocarcinoma...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25213126/rapid-in-vivo-apparent-diffusion-coefficient-mapping-of-hyperpolarized-13-c-metabolites
#19
Bertram L Koelsch, Galen D Reed, Kayvan R Keshari, Myriam M Chaumeil, Robert Bok, Sabrina M Ronen, Daniel B Vigneron, John Kurhanewicz, Peder E Z Larson
PURPOSE: Hyperpolarized (13) C magnetic resonance allows for the study of real-time metabolism in vivo, including significant hyperpolarized (13) C lactate production in many tumors. Other studies have shown that aggressive and highly metastatic tumors rapidly transport lactate out of cells. Thus, the ability to not only measure the production of hyperpolarized (13) C lactate but also understand its compartmentalization using diffusion-weighted MR will provide unique information for improved tumor characterization...
September 2015: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/25134941/the-role-of-the-bipolar-plasmakinetic-turp-over-100-g-prostate-in-the-elderly-patients
#20
Enis Rauf Coskuner, Tayyar Alp Ozkan, Sefik Koprulu, Ozdal Dillioglugil, Ibrahim Cevik
BACKGROUND AND PURPOSE: Bipolar plasma kinetic (BP) transurethral resection of prostate (TURP) has been proved to be a safe and effective treatment for benign prostatic enlargement (BPE). However, the role of bipolar TURP on large prostates over 100 g compared with open suprapubic prostatectomy (SP) in elderly patients (>65 years) has not ever been studied before. PATIENTS AND METHODS: A retrospective analysis of patients' medical records between 2007 and 2012 was performed...
November 2014: International Urology and Nephrology
keyword
keyword
41554
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"