keyword
MENU ▼
Read by QxMD icon Read
search

Brain tumour

keyword
https://www.readbyqxmd.com/read/29053791/pharmacological-targeting-of-apelin-impairs-glioblastoma-growth
#1
Elizabeth Harford-Wright, Gwennan Andre-Gregoire, Kathryn A Jacobs, Lucas Treps, Sophie Le Gonidec, Heloise M Leclair, Sara Gonzalez-Diest, Quentin Roux, François Guillonneau, Delphine Loussouarn, Lisa Oliver, François M Vallette, Fabienne Foufelle, Philippe Valet, Anthony P Davenport, Robert C Glen, Nicolas Bidere, Julie Gavard
Glioblastoma are highly aggressive brain tumours that are associated with an extremely poor prognosis. Within these tumours exists a subpopulation of highly plastic self-renewing cancer cells that retain the ability to expand ex vivo as tumourspheres, induce tumour growth in mice, and have been implicated in radio- and chemo-resistance. Although their identity and fate are regulated by external cues emanating from endothelial cells, the nature of such signals remains unknown. Here, we used a mass spectrometry proteomic approach to characterize the factors released by brain endothelial cells...
October 3, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050331/a-glo10-score-for-the-prediction-of-prognosis-in-high-grade-gliomas
#2
Feng Chen, Peng Peng, Yi Zhou, Zhen-Yu Yang, Hai-Quan Zhang, Xiang-Sheng Ao, Da-Quan Zhou, Chun-Xiang Xiang
Gliomas are the most common lethal brain tumours and remain great heterogeneity in terms of histopathology and clinical outcomes. Among them, glioblastomas are the most aggressive tumours that lead to a median of less than one-year survival in patients. Despite the little improvement of in diagnosis and treatments for last decades, there is an urgent need for prognostic markers to distinguish high- and low-risk patients before treatment.Here, we generated a list of genes associated with glioblastoma progressions and then performed a comprehensive statistical modelling strategy to derive a 10-gene (GLO10) score from genome wide expression profiles of a large glioblastoma cohort (n=844)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045397/glucose-feeds-the-tca-cycle-via-circulating-lactate
#3
Sheng Hui, Jonathan M Ghergurovich, Raphael J Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen White, Joshua D Rabinowitz
Mammalian tissues are fuelled by circulating nutrients, including glucose, amino acids, and various intermediary metabolites. Under aerobic conditions, glucose is generally assumed to be burned fully by tissues via the tricarboxylic acid cycle (TCA cycle) to carbon dioxide. Alternatively, glucose can be catabolized anaerobically via glycolysis to lactate, which is itself also a potential nutrient for tissues and tumours. The quantitative relevance of circulating lactate or other metabolic intermediates as fuels remains unclear...
October 18, 2017: Nature
https://www.readbyqxmd.com/read/29044888/nuclear-magnetic-relaxation-dispersion-of-murine-tissue-for-development-of-t1-r1-dispersion-contrast-imaging
#4
Yonathan T Araya, Francisco Martínez-Santiesteban, William B Handler, Chad T Harris, Blaine A Chronik, Timothy J Scholl
This study quantified the spin-lattice relaxation rate (R1 ) dispersion of murine tissues from 0.24 mT to 3 T. A combination of ex vivo and in vivo spin-lattice relaxation rate measurements were acquired for murine tissue. Selected brain, liver, kidney, muscle, and fat tissues were excised and R1 dispersion profiles were acquired from 0.24 mT to 1.0 T at 37 °C, using a fast field-cycling MR (FFC-MR) relaxometer. In vivo R1 dispersion profiles of mice were acquired from 1.26 T to 1.74 T at 37 °C, using FFC-MRI on a 1...
October 18, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29044454/the-role-of-telovelar-approach-in-fourth-ventricular-surgery-a-new-perspective
#5
Ehab Eissa
OBJECTIVE: Evaluation the efficiency of the telovelar approach for 4th ventricular lesions through identifying and preserving neurovascular structures. METHODS: Forty cases of fourth ventricular tumours using the telovelar approach Results: It provides adequate exposure in all cases. The brainstem and posterior inferior cerebellar artery (PICA) were early identified and preserved in all cases. Potential tumour attachment was observed at the floor of the fourth ventricle in twenty two (55%) cases, 5 of them were brain stem glioma...
August 31, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29044166/minimal-methylation-classifier-mimic-a-novel-method-for-derivation-and-rapid-diagnostic-detection-of-disease-associated-dna-methylation-signatures
#6
E C Schwalbe, D Hicks, G Rafiee, M Bashton, H Gohlke, A Enshaei, S Potluri, J Matthiesen, M Mather, P Taleongpong, R Chaston, A Silmon, A Curtis, J C Lindsey, S Crosier, A J Smith, T Goschzik, F Doz, S Rutkowski, B Lannering, T Pietsch, S Bailey, D Williamson, S C Clifford
Rapid and reliable detection of disease-associated DNA methylation patterns has major potential to advance molecular diagnostics and underpin research investigations. We describe the development and validation of minimal methylation classifier (MIMIC), combining CpG signature design from genome-wide datasets, multiplex-PCR and detection by single-base extension and MALDI-TOF mass spectrometry, in a novel method to assess multi-locus DNA methylation profiles within routine clinically-applicable assays. We illustrate the application of MIMIC to successfully identify the methylation-dependent diagnostic molecular subgroups of medulloblastoma (the most common malignant childhood brain tumour), using scant/low-quality samples remaining from the most recently completed pan-European medulloblastoma clinical trial, refractory to analysis by conventional genome-wide DNA methylation analysis...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043108/mysterious-inhibitory-cell-regulator-investigated-and-found-likely-to-be-secretogranin-ii-related
#7
John E Hart, Iain J Clarke, Gail P Risbridger, Ben Ferneyhough, Mónica Vega-Hernández
In the context of a hunt for a postulated hormone that is tissue-mass inhibiting and reproductively associated, there is described probable relatedness to a granin protein. A 7-8 kDa polypeptide candidate (gels/MS) appeared in a bioassay-guided fractionation campaign involving sheep plasma. An N-terminal sequence of 14 amino acids was obtained for the polypeptide by Edman degradation. Bioinformatics and molecular biology failed to illuminate any ovine or non-ovine protein which might relate to this sequence...
2017: PeerJ
https://www.readbyqxmd.com/read/29039591/dabrafenib-in-patients-with-recurrent-braf-v600e-mutated-malignant-glioma-and-leptomeningeal-disease
#8
Michael C Burger, Michael W Ronellenfitsch, Nadja I Lorenz, Marlies Wagner, Martin Voss, David Capper, Theophilos Tzaridis, Ulrich Herrlinger, Joachim P Steinbach, Gabriele Stoffels, Karl-Josef Langen, Christian Brandts, Christian Senft, Patrick N Harter, Oliver Bähr
BRAF V600E mutations occur frequently in malignant melanoma, but are rare in most malignant glioma subtypes. Besides, more benign brain tumors such as ganglioglioma, dysembryoblastic neuroepithelial tumours and supratentorial pilocytic astrocytomas, only pleomorphic xanthoastrocytomas (50-78%) and epitheloid glioblastoma (50%) regularly exhibit BRAF mutations. In the present study, we report on three patients with recurrent malignant gliomas harbouring a BRAF V600E mutation. All patients presented with markedly disseminated leptomeningeal disease at recurrence and had progressed after radiotherapy and alkylating chemotherapy...
October 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29035352/erratum-usp11-regulates-pml-stability-to-control-notch-induced-malignancy-in-brain-tumours
#9
Hsin-Chieh Wu, Yu-Ching Lin, Cheng-Hsin Liu, Hsiang-Ching Chung, Ya-Ting Wang, Ya-Wen Lin, Hsin-I Ma, Pang-Hsien Tu, Sean E Lawler, Ruey-Hwa Chen
This corrects the article DOI: 10.1038/ncomms4214.
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29030990/novel-nanohydrogel-of-hyaluronic-acid-loaded-with-quercetin-alone-and-in-combination-with-temozolomide-as-new-therapeutic-tool-cd44-targeted-based-of-glioblastoma-multiforme
#10
M Barbarisi, R V Iaffaioli, E Armenia, L Schiavo, G De Sena, S Tafuto, A Barbarisi, V Quagliariello
Glioblastoma multiforme is the most common and aggressive primary brain cancer with only ∼3% of patients surviving more than 3 years from diagnosis. Several mechanisms are involved in drug and radiation resistance to anticancer treatments and among them one of the most important factors is the tumour microenvironment status, characterised by cancer cell hypersecretion of interleukins and cytokines. The aim of our research was the synthesis of a nanocarrier of quercetin combined with temozolomide, to enhance the specificity and efficacy of this anticancer drug commonly used in glioblastoma treatment...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29026624/first-case-of-human-peritoneal-cysticercosis-mimicking-peritoneal-carcinosis-necessity-of-laparoscopy-and-histologic-assessment-for-the-correct-diagnosis
#11
Martina Rudelius, Klaus Brehm, Martin Poelcher, Christoph Spinner, Andreas Rosenwald, Clarissa Prazeres da Costa
Introduction. Correct diagnosis of peritoneal infectious disease can be extremely difficult due to non-specific clinical features. Thus, careful assessment with thorough histopathological work-up is essential. Here, we report the first case of human peritoneal cysticercosis mimicking peritoneal carcinosis. Case presentation. The patient presented with recurring ascites and a tumour in the Douglas cavity accompanied by elevated tumour markers. There were no signs of systemic infection. On laparoscopy, the tumour was resected completely...
June 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026176/primary-astrocytic-tumours-and-paired-recurrences-have-similar-biological-features-in-idh1-tp53-and-tertp-mutation-and-mgmt-atrx-loss
#12
Xia Li, Jie Wei, Yixiong Liu, Peifeng Li, Linni Fan, Yingmei Wang, Mingyang Li, Danhui Zhao, Zhou Yu, Jing Ye, Ying Guo, Qingguo Yan, Shuangping Guo, Zhe Wang
Astrocytic tumours are the most common type of primary malignant brain tumour. Most astrocytic tumours will recur at some point after surgery. Currently, the combination of radiotherapy and chemotherapy does not prevent the recurrence of astrocytic tumours. In this study, we investigated the consistency in isocitrate dehydrogenase 1 (IDH1), tumour protein p53 (TP53) and telomerase reverse transcriptase promoter (TERTp) mutations during astrocytic tumour recurrence. We also evaluated the protein loss of O-6-methylguanine-DNA methyltransferase (MGMT) and alpha-thalassemia/mental retardation, X-linked (ATRX) during disease recurrence...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024558/overweight-obesity-and-adiposity-in-survivors-of-childhood-brain-tumours-a-systematic-review-and-meta-analysis
#13
REVIEW
K-W Wang, A Fleming, D L Johnston, S M Zelcer, S R Rassekh, S Ladhani, A Socha, J Shinuda, S Jaber, S Burrow, S K Singh, L Banfield, R J de Souza, L Thabane, M C Samaan
Survivors of childhood brain tumours (SCBT) have increased cardiometabolic risks, but the determinants of these risks are unclear. This systematic review aims to compare the prevalence of overweight and obesity as well as adiposity measures between SCBT and non-cancer controls. The PubMed, EMBASE, MEDLINE, CINAHL and the Cochrane Library databases were searched. The primary outcomes were the prevalence of overweight and obesity based on body mass index. The secondary outcomes were adiposity measures including percent fat mass, waist-to-hip and waist-to-height ratios...
October 11, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29020502/persistence-of-dna-adducts-hypermutation-and-acquisition-of-cellular-resistance-to-alkylating-agents-in-glioblastoma
#14
R J Head, M F Fay, L Cosgrove, K Y C Fung, D Rundle-Thiele, J H Martin
Glioblastoma is a lethal form of brain tumour usually treated by surgical resection followed by radiotherapy and an alkylating chemotherapeutic agent. Key to the success of this multimodal approach is maintaining apoptotic sensitivity of tumour cells to the alkylating agent. This initial treatment likely establishes conditions contributing to development of drug resistance as alkylating agents form the O(6)-methylguanine adduct. This activates the mismatch repair (MMR) process inducing apoptosis and mutagenesis...
October 11, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28993028/the-case-for-dna-methylation-based-molecular-profiling-to-improve-diagnostic-accuracy-for-central-nervous-system-embryonal-tumors-not-otherwise-specified-in-adults
#15
Gail C Halliday, Reimar C Junckerstorff, Jacqueline M Bentel, Andrew Miles, David T W Jones, Volker Hovestadt, David Capper, Raelene Endersby, Catherine H Cole, Tom van Hagen, Nicholas G Gottardo
Central nervous system primitive neuro-ectodermal tumors (CNS-PNETs), have recently been re-classified in the most recent 2016 WHO Classification into a standby catch all category, "CNS Embryonal Tumor, not otherwise specified" (CNS embryonal tumor, NOS) based on epigenetic, biologic and histopathologic criteria. CNS embryonal tumors (NOS) are a rare, histologically and molecularly heterogeneous group of tumors that predominantly affect children, and occasionally adults. Diagnosis of this entity continues to be challenging and the ramifications of misdiagnosis of this aggressive class of brain tumors are significant...
October 6, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28992727/neuroendoscopic-and-histopathological-correlation-in-13-cases-of-cystic-fluid-filled-brain-tumours
#16
Oh Jimenez-Vazquez, Norma Nagore
Neuroendoscopical images of fluid-filled cavity walls within encephalic tumours in thirteen adult patients were correlated with histopathology results of samples harvested during surgery. Extensive vascular proliferation, with mesh-like formations in a 3D pattern, as well as onionskin appearance, were observed in malignant tumours, as opposed to normal or slightly increased vascular pattern, observed in benign neoplasms. Medical facilities lacking sufficient technical resources where limited pathologist experience is expected, and can be associated with intraoperative histological misdiagnosis...
October 9, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28989676/rapid-determination-of-medulloblastoma-subgroup-affiliation-with-mass-spectrometry-using-a-handheld-picosecond-infrared-laser-desorption-probe
#17
Michael Woolman, Isabelle Ferry, Claudia M Kuzan-Fischer, Megan Wu, Jing Zou, Taira Kiyota, Semra Isik, Delaram Dara, Ahmed Aman, Sunit Das, Michael D Taylor, James T Rutka, Howard J Ginsberg, Arash Zarrine-Afsar
Medulloblastoma (MB), the most prevalent malignant childhood brain tumour, consists of at least 4 distinct subgroups each of which possesses a unique survival rate and response to treatment. To rapidly determine MB subgroup affiliation in a manner that would be actionable during surgery, we subjected murine xenograft tumours of two MB subgroups (SHH and Group 3) to Mass Spectrometry (MS) profiling using a handheld Picosecond InfraRed Laser (PIRL) desorption probe and interface developed by our group. This platform provides real time MS profiles of tissue based on laser desorbed lipids and small molecules with only 5-10 seconds of sampling...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28988669/-meningeal-metastasis-of-uterine-leiomyosarcoma-case-report-and-literature-review
#18
Pablo Sosa, Gabriela Cuadra, Raul Hidalgo
Brain metastases are the most commonly seen intracranial lesions in adults. What is more, meningiomas are the most common primary intracranial tumours after gliomas and their imaging characteristics are well known in both CT and MRI scans. However, there are lesions that can mimic meningiomas in imaging studies, including metastases of extracranial tumours, confronting us with a diagnostic and therapeutic challenge. We present the case of a patient with meningeal metastasis of a uterine leiomyosarcoma that was not known at the time of the surgical intervention...
October 4, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28988668/-neurophysiological-monitoring-options-in-brain-tumour-resections-consensus-statement-from-the-spanish-society-of-neurosurgery-s-senec-neuro-oncology-working-group-and-the-spanish-society-of-clinical-neurophysiology-senfc
#19
Cristian de Quintana-Schmidt, Estela Lladó-Carbo, Victoria Eugenia Cortés-Doñate
Brain tumours located in or in proximity to eloquent areas are a significant neurosurgical challenge. Performing this kind of surgery with neurophysiological monitoring to improve resections with reduced permanent focal neurological deficit has become widely accepted in the literature. However, how to conduct this monitoring, the exact definition of an eloquent area and whether to perform this surgery with the patient awake or asleep are still subject to rigorous scientific debate. Members of the Neuro-oncology Working Group (GTNO) of the Spanish Society of Neurosurgery (SENEC) and members of the Spanish Society of Clinical Neurophysiology (SENFC) have published a consensus statement to explain the different neurophysiological monitoring options currently available in awake and asleep patients to obtain better surgical resection without neurological deficits...
October 5, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28987827/surgical-management-of-giant-intracranial-meningioma-operative-nuances-challenges-and-outcome
#20
Vinayak Narayan, Shyamal C Bir, Nasser Mohammed, Amey R Savardekar, Devi Prasad Patra, Anil Nanda
INTRODUCTION: The giant intracranial meningioma [GIM] constitutes a different spectrum of brain tumors which invade the vital neurovascular structures and makes the primary mode of treatment, surgery, a technically challenging one. The surgery of GIM is unique due to its large size, prominent vascularity, entangling and limited visualisation of various neurovascular structures and severe cerebral edema. The study reports the authors surgical experience of 80 GIM cases, the operative challenges and surgical outcome...
October 5, 2017: World Neurosurgery
keyword
keyword
41553
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"