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https://www.readbyqxmd.com/read/29450203/real-life-experience-of-ceritinib-in-crizotinib-pretreated-alk-advanced-non-small-cell-lung-cancer-patients
#1
Jacques Cadranel, Alexis B Cortot, Hervé Lena, Bertrand Mennecier, Pascal Do, Eric Dansin, Julien Mazieres, Christos Chouaid, Maurice Perol, Fabrice Barlesi, Gilles Robinet, Sylvie Friard, Luc Thiberville, Clarisse Audigier-Valette, Alain Vergnenegre, Virginie Westeel, Khemaies Slimane, Alexandru Buturuga, Denis Moro-Sibilot, Benjamin Besse
Here we report our experience of ceritinib in crizotinib-pretreated patients with anaplastic lymphoma kinase ( ALK ) positive ( ALK + ) non-small cell lung cancer (NSCLC) in a French temporary authorisation for use (TAU) study. The French TAU study included crizotinib-pretreated patients with advanced ALK + or ROS proto-oncogene 1 positive ( ROS1 + ) tumours. Patients received oral ceritinib (750 mg·day -1 as a starting dose) and best tumour response (as evaluated by the investigator) and safety were reported every 3 months...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29446978/supratentorial-extension-of-large-cerebellar-pilocytic-astrocytoma-in-adult
#2
Saraj Kumar Singh, Himanshu Agarwal
A Neuroimage of a cerebellar pilocytic astrocytoma with supratentorial extension in a 26 year old male illustraiting how slow growing brain tumours expand respecting dural but not neural barriers.
February 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29445035/comparative-dynamics-of-microglial-and-glioma-cell-motility-at-the-infiltrative-margin-of-brain-tumours
#3
Joseph Juliano, Orlando Gil, Andrea Hawkins-Daarud, Sonal Noticewala, Russell C Rockne, Jill Gallaher, Susan Christine Massey, Peter A Sims, Alexander R A Anderson, Kristin R Swanson, Peter Canoll
Microglia are a major cellular component of gliomas, and abundant in the centre of the tumour and at the infiltrative margins. While glioma is a notoriously infiltrative disease, the dynamics of microglia and glioma migratory patterns have not been well characterized. To investigate the migratory behaviour of microglia and glioma cells at the infiltrative edge, we performed two-colour time-lapse fluorescence microscopy of brain slices generated from a platelet-derived growth factor-B (PDGFB)-driven rat model of glioma, in which glioma cells and microglia were each labelled with one of two different fluorescent markers...
February 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29441571/arterial-and-microvascular-supply-of-cerebral-hemispheres-in-the-nude-mouse-revealed-using-corrosion-casting-and-scanning-electron-microscopy
#4
Simone Sangiorgi, Alessandro De Benedictis, Marcella Reguzzoni, Andrea Trezza, Silvia Cossu, Carlo Efisio Marras, Silvio Bellocchi, Alessandro Manelli, Marina Protasoni
Morphological analyses of cerebral vascularization are not only important for the characterization of the anatomical and physiological relationships between vascular and nervous tissue, but also required to understand structural modifications that occur in many pathological conditions affecting the brain. The aim of this study was to generate a three-dimensional vascular map of the cerebral hemispheres in the nude mouse brain, a widely used animal model for studying tumour biology. We used the corrosion casting (CC) technique to isolate blood vessels from 30 nude mouse brains...
February 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29438386/doxycycline-inhibits-experimental-cerebral-malaria-by-reducing-inflammatory-immune-reactions-and-tissue-degrading-mediators
#5
Kim E Schmidt, Janina M Kuepper, Beatrix Schumak, Judith Alferink, Andrea Hofmann, Shanshan W Howland, Laurent Rénia, Andreas Limmer, Sabine Specht, Achim Hoerauf
Malaria ranks among the most important infectious diseases worldwide and affects mostly people living in tropical countries. Mechanisms involved in disease progression are still not fully understood and specific treatments that might interfere with cerebral malaria (CM) are limited. Here we show that administration of doxycycline (DOX) prevented experimental CM (ECM) in Plasmodium berghei ANKA (PbA)-infected C57BL/6 wildtype (WT) mice in an IL-10-independent manner. DOX-treated mice showed an intact blood-brain barrier (BBB) and attenuated brain inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29436665/microrna-375-inhibits-glioma-cell-proliferation-and-migration-by-downregulating-rwdd3-in%C3%A2-vitro
#6
Chen-Xing Ji, Yang-Hua Fan, Fan Xu, Shi-Gang Lv, Min-Hua Ye, Miao-Jing Wu, Xin-Gen Zhu, Lei Wu
Derived from brain glial cells, gliomas are currently the most common primary tumours in the central nervous system and are characterised by a high recurrence rate and poor prognosis. RWDD3 (RWD domain-containing sumoylation enhancer, also termed RSUME), which can be induced by cellular stress, such as CoCl2, heat shock and hypoxia, may play a crucial role in tumour angiogenesis, growth and metastasis. MicroRNAs (miRNAs) have been demonstrated to act as negative regulators of post-transcriptional gene expression and are involved in tumour growth and metastasis...
February 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29435827/hydrocephalus-in-children-under-the-age-of-five-from-diagnosis-to-short-medium-long-term-progression-a-retrospective-review-of-142-children
#7
Océane Perdaens, Guus Koerts, Marie-Cécile Nassogne
The aim of this study is to evaluate the clinical history and prognosis of children with early-onset hydrocephalus. The retrospective study's inclusion criteria were hydrocephalus diagnosis before the age of 5 years, independent of aetiology, and birth details, January 1, 2000 to December 31, 2014. Overall, 142 children were entered into the study, divided into 11 aetiological groups: premature-birth post-intraventricular haemorrhage (16%), brain tumours (16%), spina bifida (15%), aqueductal stenosis (8%), post-meningitis (8%), post-haemorrhage (8%), Dandy-Walker malformation (6%), unknown origin (6%), arachnoid cyst (5%), miscellaneous obstruction (4%), and various causes (8%)...
February 12, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29435413/the-e3-ubiquitin-ligase-murf2-attenuates-lps-induced-macrophage-activation-by-inhibiting-production-of-inflammatory-cytokines-and-migration
#8
Hongjun Bian, Shanshan Gao, Di Zhang, Qi Zhao, Feifei Li, Xiao Li, Shuohuan Sun, Shouyang Song, Tao Li, Qiang Zhu, Wanhua Ren, Chengyong Qin, Jianni Qi
Muscle RING-finger (MuRF) proteins are E3 ubiquitin ligases that are expressed in striated muscle. MuRF2 is an important member of this family, but whether it is expressed in tissues other than striated muscle has not been thoroughly elucidated to date. In this study, we determined that MuRF2 is also expressed in other vital organs, including liver, lung, brain, spleen and kidney. Moreover, we show that the level of MuRF2 expression is significantly decreased in hepatic mononuclear cells of mice with lipopolysaccharide (LPS)/d-galactosamine-induced hepatitis and negatively correlated with the serum levels of alanine aminotransferase and aspartate aminotransferase in these mice...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29434677/the-constitutively-active-pkg-ii-mutant-effectively-inhibits-gastric-cancer-development-via-a-blockade-of-egf-egfr-associated-signalling-cascades
#9
Yan Wu, Miaomiao Yuan, Wenbin Su, Miaolin Zhu, Xiaoyuan Yao, Ying Wang, Hai Qian, Lu Jiang, Yan Tao, Min Wu, Ji Pang, Yongchang Chen
Type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) is a membrane-anchored enzyme expressed mainly in the intestinal mucosa and the brain, and is associated with various physiological or pathological processes. Upregulation of PKG II is known to induce apoptosis and inhibit proliferation and metastasis of cancer cells. The inhibitory effect of PKG II has been shown to be dependent on the inhibition of the activation of epidermal growth factor receptor (EGFR) and blockade of EGFR downstream signal transduction in vitro...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29433564/high-dose-thiotepa-related-neurotoxicity-and-the-role-of-tramadol-in-children
#10
Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet, Christelle Dufour
BACKGROUND: Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to high-dose thiotepa and to identify potential contributing factors that could exacerbate the occurrence of this neurotoxicity. METHODS: From May 1987 to March 2011, children with solid tumours treated with high-dose thiotepa were retrospectively identified...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29428932/metabolite-levels-in-paediatric-brain-tumours-correlate-with-histological-features
#11
Eleni Orphanidou-Vlachou, Sarah E Kohe, Marie-Anne Brundler, Lesley MacPherson, Yu Sun, Nigel Davies, Martin Wilson, Xiaoyan Pan, Theodoros N Arvanitis, Richard G Grundy, Andrew C Peet
AIMS: Metabolite levels can be measured non-invasively using in vivo 1H magnetic resonance spectroscopy (MRS). These tumour metabolite profiles are highly characteristic for tumour type in childhood brain tumours; however, the relationship between metabolite values and conventional histopathological characteristics has not yet been fully established. This study systematically tests the relationship between metabolite levels detected by MRS and specific histological features in a range of paediatric brain tumours...
February 10, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29423615/defining-spasticity-a-new-approach-considering-current-movement-disorders-terminology-and-botulinum-toxin-therapy
#12
Dirk Dressler, Roongroj Bhidayasiri, Saeed Bohlega, Pedro Chana, Hsin Fen Chien, Tae Mo Chung, Carlo Colosimo, Markus Ebke, Klemens Fedoroff, Bernd Frank, Ryuji Kaji, Petr Kanovsky, Serdar Koçer, Federico Micheli, Olga Orlova, Sebastian Paus, Zvezdan Pirtosek, Maja Relja, Raymond L Rosales, José Alberto Sagástegui-Rodríguez, Paul W Schoenle, Gholam Ali Shahidi, Sofia Timerbaeva, Uwe Walter, Fereshte Adib Saberi
Spasticity is a symptom occurring in many neurological conditions including stroke, multiple sclerosis, hypoxic brain damage, traumatic brain injury, tumours and heredodegenerative diseases. It affects large numbers of patients and may cause major disability. So far, spasticity has merely been described as part of the upper motor neurone syndrome or defined in a narrowed neurophysiological sense. This consensus organised by IAB-Interdisciplinary Working Group Movement Disorders wants to provide a brief and practical new definition of spasticity-for the first time-based on its various forms of muscle hyperactivity as described in the current movement disorders terminology...
February 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29421583/icariside-ii-attenuates-myocardial-fibrosis-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-and-the-tgf-%C3%AE-1-smad2-signalling-pathway-in-spontaneously-hypertensive-rats
#13
Shu Fu, Ye-Li Li, Yu-Ting Wu, Yun Yue, Zhi-Qiang Qian, Dan-Li Yang
Studies have demonstrated that icariin plays important roles in preventing hypertension and improving myocardial hypertrophy, inflammatory and infiltration. Icariside (ICS II) is the main metabolite of icariin, which has anti-inflammatory and anti-oxidant activities and protects against ischaemic brain injury. Whether ICS II improves myocardial fibrosis in spontaneously hypertensive rats (SHRs) and the related mechanism remain unknown. Some studies have suggested that TGF-β and the nuclear factor κB signalling pathway play a key role in the progression of myocardial fibrosis...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29420713/symptoms-in-primary-care-with-time-to-diagnosis-of-brain-tumours
#14
Mio Ozawa, Paul M Brennan, Karolis Zienius, Kathreena M Kurian, William Hollingworth, David Weller, Willie Hamilton, Robin Grant, Yoav Ben-Shlomo
Background: Brain tumours often present with varied, non-specific features with other diagnoses usually being more likely. Objective: To examine how different symptoms and patient demographics predict variations in time to brain tumour diagnosis. Methods: We conducted a secondary analysis of brain tumour cases from National Audit of Cancer Diagnosis in Primary Care. We grouped neurological symptoms into six domains (headache, behavioural/cognitive change, focal neurology, 'fits, faints or falls', non-specific neurological, and other/non-specific) and calculated times for patient presentation, GP referral, specialist consultation and total pathway interval...
February 6, 2018: Family Practice
https://www.readbyqxmd.com/read/29420678/cerebral-pneumography-and-the-20th-century-localization-of-brain-tumours
#15
Bart Lutters, Peter J Koehler
No abstract text is available yet for this article.
February 6, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29419328/brain-focused-ultrasound-what-s-the-fus-all-about-a-review-of-current-and-emerging-neurological-applications
#16
Laure Bretsztajn, Wladyslaw Gedroyc
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) allows for precise non-invasive thermal ablation of target tissues for a wide range of clinical applications. It is an innovative and rapidly expanding technology which has already established itself as an effective and safe incisionless alternative in the treatment of various soft tissue tumours, with many more research studies underway to extend its therapeutic envelope. The non-invasiveness of the procedure makes FUS particularly attractive in functional neurosurgery, where existing treatment options are not suitable for all patients...
February 8, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29411466/writing-fluency-in-patients-with-low-grade-glioma-before-and-after-surgery
#17
Malin Antonsson, Charlotte Johansson, Lena Hartelius, Ingrid Henriksson, Francesca Longoni, Åsa Wengelin
BACKGROUND: Low-grade glioma (LGG) is a type of brain tumour often situated in or near areas involved in language, sensory or motor functions. Depending on localization and tumour characteristics, language or cognitive impairments due to tumour growth and/or surgical resection are obvious risks. One task that may be at risk is writing, both because it requires intact language and memory function and because it is a very complex and cognitively demanding task. The most commonly reported language deficit in LGG patients is oral lexical-retrieval difficulties, and poor lexical retrieval would be expected to affect writing fluency...
February 7, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29411111/functional-morphology-of-the-blood-brain-barrier-in-health-and-disease
#18
REVIEW
Stefan Liebner, Rick M Dijkhuizen, Yvonne Reiss, Karl H Plate, Dritan Agalliu, Gabriela Constantin
The adult quiescent blood-brain barrier (BBB), a structure organised by endothelial cells through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular unit, is highly regulated but fragile at the same time. In the past decade, there has been considerable progress in understanding not only the molecular pathways involved in BBB development, but also BBB breakdown in neurological diseases. Specifically, the Wnt/β-catenin, retinoic acid and sonic hedgehog pathways moved into the focus of BBB research...
February 6, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29407575/anti-inflammatory-effects-of-anisalcohol-on-lipopolysaccharide-stimulated-bv2-microglia-via-selective-modulation-of-microglia-polarization-and-down-regulation-of-nf-%C3%AE%C2%BAb-p65-and-jnk-activation
#19
Bin Xiang, Chun Xiao, Ting Shen, Xiufang Li
Inflammation plays a pivotal role in the pathogenesis of ischemic stroke. The inhibition of inflammation appears to be a potential therapeutic strategy for neuro-inflammatory injury after ischemic stroke. In response to cerebral ischemia, resident microglia and infiltrated macrophages from the damaged blood-brain barrier are activated. Microglia activation appears to be a double-edged sword. Activated microglia migrate to the damaged neuron, change their phenotype to M1 or M2, and become involved in nerve damage and repair...
January 29, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29404703/the-role-of-computed-tomography-in-the-screening-of-patients-presenting-with-symptoms-of-an-intracranial-tumour
#20
Sharri Junadi Mortensen, Shima Naebi Bjerrum, Stine Frost Hedegaard, Anna Tietze, Hanne Gottrup, Gorm von Oettingen
BACKGROUND: To improve the quality of care for brain cancer patients, the Danish Ministry of Health has set standards for the diagnosis and treatment. When a patient is suspected of having a malignant tumour involving the brain, it is required that a magnetic resonance imaging of the cerebrum (MRI-C) be obtained within seven calendar days of referral from a primary care provider. This standard has the potential to consume MR imaging time that might otherwise be used for evaluation or treatment monitoring of other patients...
February 5, 2018: Acta Neurochirurgica
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