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https://www.readbyqxmd.com/read/29321993/sansoninto-a-traditional-herbal-medicine-ameliorates-behavioral-abnormalities-and-down-regulation-of-early-growth-response-1-expression-in-mice-exposed-to-social-isolation-stress
#1
Hironori Fujiwara, Ryohei Tsushima, Ryo Okada, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
Social isolation (SI) mice exhibit behavioral abnormalities such as impairments of sociability- and attention-like behaviors, offering an animal model of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD). This study aimed to identify the effects of Sansoninto (SST; suān zǎo rén tāng) on the psychiatric symptoms related to ADHD using SI mice. Four-week-old mice were socially isolated during the experimental period, and SST administration (800 or 2400 mg/kg, p.o.) was started at 2 weeks after starting SI...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29317682/piperonylic-acid-stimulates-keratinocyte-growth-and-survival-by-activating-epidermal-growth-factor-receptor-egfr
#2
Dohyun Lee, Jinsun Lim, Kyung-Chul Woo, Kyong-Tai Kim
Epidermal growth factor (EGF) stimulates cell growth, proliferation, and survival. The biological benefits of EGF have been utilized in medical uses for improving wound healing as well as in today's skin cosmetics. EGF has been found in urine, saliva, milk, and plasma, but its efficient isolation remains a difficult task. With technical advances, recombinant protein purification technique has been used for EGF production. However, the recombinant EGF is still expensive and keeping it with stable activity is difficult to be used widely...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305012/regulation-of-gene-transcription-following-stimulation-of-transient-receptor-potential-trp-channels
#3
Gerald Thiel, Andrea Lesch, Sandra Rubil, Tobias M Backes, Oliver G Rössler
Transient receptor potential (TRP) channels belong to a heterogeneous superfamily of cation channels that are involved in the regulation of numerous biological functions, including regulation of Ca2+ and glucose homeostasis, tumorigenesis, temperature, and pain sensation. To understand the functions of TRP channels, their associated intracellular signaling pathways and molecular targets have to be identified on the cellular level. Stimulation of TRP channels frequently induces an influx of Ca2+ ions into the cells and the subsequent activation of protein kinases...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29288726/phenylethanolamine-n-methyltransferase-gene-expression-in-pc12-cells-exposed-to-intermittent-hypoxia
#4
Sandhya Khurana, Siyuan Peng, Erika McDonald, William Yates, Krishnan Venkataraman, T C Tai
Epidemiological studies show a strong correlation between Obstructive Sleep Apnea (OSA) and cardiovascular disorders. OSA patients experience intermittent hypoxia (IH), characterized by brief, but recurring episodes of cessation in breathing. These patients have higher levels of circulating catecholamines and an increased incidence of hypertension; however the mechanisms defining this association are not clearly established. Genetic linkage studies have associated the phenylethanolamine N-methyltransferase (PNMT) gene to the development of hypertension...
December 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29282485/identification-of-a-novel-lncrna-induced-by-the-nephrotoxin-ochratoxin-a-and-expressed-in-human-renal-tumor-tissue
#5
Mirjana Polovic, Sandro Dittmar, Isabell Hennemeier, Hans-Ulrich Humpf, Barbara Seliger, Paolo Fornara, Gerit Theil, Patrick Azinovic, Alexander Nolze, Marcel Köhn, Gerald Schwerdt, Michael Gekle
Long non-coding RNAs represent a fraction of the transcriptome that is being increasingly recognized. For most of them no function has been allocated so far. Here, we describe the nature and function of a novel non-protein-coding transcript, named WISP1-AS1, discovered in human renal proximal tubule cells exposed to the carcinogenic nephrotoxin ochratoxin A. WISP1-AS1 overlaps parts of the fourth intron and fifth exon of the Wnt1-inducible signaling pathway protein 1 (WISP1) gene. The transcript is 2922 nucleotides long, transcribed in antisense direction and predominantly localized in the nucleus...
December 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29259250/snail-collaborates-with-egr-1-and-sp-1-to-directly-activate-transcription-of-mmp-9-and-zeb1
#6
Wen-Sheng Wu, Ren-In You, Chuan-Chu Cheng, Ming-Che Lee, Teng-Yi Lin, Chi-Tan Hu
The Snail transcription factor plays as a master regulator of epithelial mesenchymal transition (EMT), one of the steps of tumor metastasis. Snail enhances expressions of a lot of mesenchymal genes including the matrix degradation enzyme matrix metalloproteinases 9 (MMP9) and the EMT transcription factor zinc finger E-box binding homeobox 1 (ZEB1), however, the underlying mechanisms are not clarified. Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222058/differential-expression-of-the-immediate-early-genes-c-fos-arc-egr-1-and-npas4-during-long-term-memory-formation-in-the-context-preexposure-facilitation-effect-cpfe
#7
Nicholas A Heroux, Brittany F Osborne, Lauren A Miller, Malak Kawan, Katelyn N Buban, Jeffrey B Rosen, Mark E Stanton
No abstract text is available yet for this article.
December 5, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29216821/molecular-targets-and-signaling-pathways-regulated-by-nuclear-translocation-of-syndecan-1
#8
Tünde Szatmári, Filip Mundt, Ashish Kumar-Singh, Lena Möbus, Rita Ötvös, Anders Hjerpe, Katalin Dobra
BACKGROUND: The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell cycle regulation in a broad spectrum of malignancies. Syndecan-1, however, also translocates to the cell nucleus, where it might regulate various molecular functions. RESULTS: We used a fibrosarcoma model to dissect the functions of syndecan-1 related to the nucleus and separate them from functions related to the cell-surface. Nuclear translocation of syndecan-1 hampered the proliferation of fibrosarcoma cells compared to the mutant lacking nuclear localization signal...
December 8, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/29212876/egr-1-mediates-leptin-induced-ppar%C3%AE-reduction-and-proliferation-of-pulmonary-artery-smooth-muscle-cells
#9
Xinming Xie, Shaojun Li, Yanting Zhu, Lu Liu, Rui Ke, Jian Wang, Xin Yan, Lan Yang, Li Gao, Weijin Zang, Manxiang Li
Loss of peroxisome proliferator-activated receptor γ (PPARγ) has been found to contribute to pulmonary artery smooth muscle cell (PASMC) proliferation and pulmonary arterial remodeling therefore the development of pulmonary hypertension (PH). Yet, the molecular mechanisms underlying PPARγ reduction in PASMC remain poorly understood. Here, we demonstrated that leptin dose- and time-dependently inducued PPARγ down-regulation and proliferation of primary cultured rat PASMC, this was accompanied with the activation of extracellular regulated kinase1/2 (ERK1/2) signaling pathway and subsequent induction of early growth response-1 (Egr-1) expression...
December 6, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29207655/egr-1-regulates-rta-transcription-through-a-cooperative-involvement-of-transcriptional-regulators
#10
Roni Sarkar, Subhash C Verma
Kaposi's sarcoma associated herpesvirus (KSHV) regulates the host cellular environment to establish life-long persistent infection by manipulating cellular signaling pathways, with approximately 1- 5% of cells undergoing lytic reactivation during the course of infection. Egr-1 (Early Growth Response Factor-1) is one such cellular transcription factor, which gets phosphorylated during the lytic phase of viral life cycle to perpetrate its function. This study demonstrates the mechanism of how Egr-1 mediates transcription of the immediate early gene, RTA (Replication and transcription activator), which is the lytic switch gene of KSHV...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29189019/across-sex-and-age-learning-and-memory-and-patterns-of-avian-hippocampal-gene-expression
#11
Saritha Kosarussavadi, Zachary T Pennington, Jeremy Covell, Aaron P Blaisdell, Barney A Schlinger
Age-related decrements in cognitive ability have been proposed to stem from deteriorating function of the hippocampus. Many birds are long lived, especially for their relatively small body mass and elevated metabolism, making them a unique model of resilience to aging. Nevertheless, little is known about avian age-related changes in cognition and hippocampal physiology. We studied spatial cognition and hippocampal expression of the age-related gene, Apolipoprotein D (ApoD), and the immediate early gene Egr-1 in zebra finches at various developmental time points...
December 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29133030/20-s-protopanaxadiol-ppd-alleviates-scopolamine-induced-memory-impairment-via-regulation-of-cholinergic-and-antioxidant-systems-and-expression-of-egr-1-c-fos-and-c-jun-in-mice
#12
Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu
20(S)-protopanaxadiol (PPD) possesses various biological properties, including anti-inflammatory, antitumor and anti-fatigue properties. Recent studies found that PPD functioned as a neurotrophic agent to ameliorate the sensory deficit caused by glutamate-induced excitotoxicity through its antioxidant effects and exhibited strong antidepressant-like effects in vivo. The objective of the present study was first to investigate the effect of PPD in scopolamine (SCOP)-induced memory deficit in mice and the potential mechanisms involved...
November 10, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29129814/zinc-deficiency-promotes-cystitis-related-bladder-pain-by-enhancing-function-and-expression-of-cav3-2-in-mice
#13
Tomoka Ozaki, Junki Matsuoka, Maho Tsubota, Shiori Tomita, Fumiko Sekiguchi, Takeshi Minami, Atsufumi Kawabata
Cav3.2 T-type Ca(2+) channel activity is suppressed by zinc that binds to the extracellular histidine-191 of Cav3.2, and enhanced by H2S that interacts with zinc. Cav3.2 in nociceptors is upregulated in an activity-dependent manner. The enhanced Cav3.2 activity by H2S formed by the upregulated cystathionine-γ-lyase (CSE) is involved in the cyclophosphamide (CPA)-induced cystitis-related bladder pain in mice. We thus asked if zinc deficiency affects the cystitis-related bladder pain in mice by altering Cav3...
November 10, 2017: Toxicology
https://www.readbyqxmd.com/read/29129138/the-role-of-zn-complex-in-binding-of-transcription-factors-to-operator-dna-mouse%C3%A2-egr-1-from-the-cys2his2-family
#14
Y N Chirgadze, E A Boshkova, R V Polozov, V S Sivozhelezov, A V Dzyabchenko, M B Kuzminsky, V A Stepanenko, V V Ivanov
The mouse factor Zif268, known also as early growth response protein EGR-1, is a classical representative for the Cys2His2 transcription factor family. It is required for binding the RNA polymerase with operator dsDNA to initialize the transcription process. We have shown that only in this family of total six Zn-finger protein families the Zn complex plays a significant role in the protein-DNA binding. Electrostatic feature of this complex in the binding of factor Zif268 from Mus musculus with operator DNA has been considered...
November 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29117505/changes-in-behavior-and-brain-immediate-early-gene-expression-in-male-threespined-sticklebacks-as-they-become-fathers
#15
Molly Kent, Alison M Bell
Motherhood is a period of intense behavioral and brain activity. However, we know less about the neural and molecular mechanisms associated with the demands of fatherhood. Here, we report the results of two experiments designed to track changes in behavior and brain activation associated with fatherhood in male threespined stickleback fish (Gasterosteus aculeatus), a species in which fathers are the sole providers of parental care. In experiment 1, we tested whether males' behavioral reactions to different social stimuli depends on parental status, i...
November 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29106686/the-identification-of-pivotal-transcriptional-factors-mediating-cell-responses-to-drugs-with-drug-induced-liver-injury-liabilities
#16
Falgun Shah, Alex Medvedev, Anne Mai Wassermann, Marian Brodney, Liying Zhang, Sergei Makarov, Robert V Stanton
Drug-induced liver injury (DILI) is a leading cause of drug attrition during drug development and a common reason for drug withdrawal from the market. The poor predictability of conventional animal-based approaches (Olson et al. 2000) necessitates the development of alternative testing approaches. Body of evidence associates DILI with the induction of stress-response genes in the liver cells (Yuan and Kaplowitz 2013). Here, we set out to identify signal transduction pathways predominantly involved in the regulation of gene transcription by DILI drugs...
November 2, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29066839/calcineurin-p-erk-egr-1-pathway-is-involved-in-fear-memory-impairment-after-isoflurane-exposure-in-mice
#17
Xiaoxuan Yang, Guohui Li, Qingsheng Xue, Yan Luo, Sensen Wang, Yimeng Xia, Lei Zhuang, Buwei Yu
Isoflurane exposure adversely influences subsequent fear memory formation in mice. Calcineurin (CaN), a phosphatase, prevents the establishment of emotional memory by dephosphorylating substrates and inhibiting the expression of learning and memory related genes. We investigated whether isoflurane impairment of fear memory formation was associated with altered CaN activity and downstream phosphorylated-extracellular signal-regulated kinases (p-ERK) and early growth response gene-1 (Egr-1) expression in hippocampus and amygdala...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29031547/forebrain-activation-during-social-exposure-in-wild-type-guppies
#18
María J Cabrera-Álvarez, William T Swaney, Simon M Reader
The neural mechanisms regulating social behaviour have received extensive attention in recent years, with much focus on 'complex' forms of sociality. Comparatively little research has addressed fundamental social behaviour, such as grouping, which impacts multiple determinants of fitness, such as foraging and avoiding predation. We are interested in the degree to which brain areas that regulate other forms of sociality are also involved in grouping behaviour, and so we investigated shoal-elicited activation of the brain in the guppy (Poecilia reticulata)...
December 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28991232/the-extracellular-matrix-protein-mindin-attenuates-colon-cancer-progression-by-blocking-angiogenesis-via-egr-1-mediated-regulation
#19
L-F Wang, Y-S Liu, B Yang, P Li, X-S Cheng, C-X Xiao, J-J Liu, S Li, J-L Ren, B Guleng
Mindin, a secreted, highly conserved extracellular matrix (ECM) protein, exerts a broad spectrum of effects on the innate immune system. However, its function in colorectal cancer (CRC) progression is not well established, and its upstream regulation mechanisms remain unclear. Contrary to previous reports, this study used two different enzyme-linked immunosorbent assay (ELISA) kits to show that the serum level of mindin was significantly decreased in CRC patients and that this decreased level is more significantly associated with the early stages of the disease...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28987007/honey-bee-foraging-induces-upregulation-of-early-growth-response-protein-1-hormone-receptor-38-and-candidate-downstream-genes-of-the-ecdysteroid-signalling-pathway
#20
A S Singh, A Shah, A Brockmann
In honey bees, continuous foraging at an artificial feeder induced a sustained upregulation of the immediate early genes early growth response protein 1 (Egr-1) and hormone receptor 38 (Hr38). This gene expression response was accompanied by an upregulation of several Egr-1 candidate downstream genes: ecdysone receptor (EcR), dopamine/ecdysteroid receptor (DopEcR), dopamine decarboxylase and dopamine receptor 2. Hr38, EcR and DopEcR are components of the ecdysteroid signalling pathway, which is highly probably involved in learning and memory processes in honey bees and other insects...
October 7, 2017: Insect Molecular Biology
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