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https://www.readbyqxmd.com/read/27891497/mechanisms-involved-in-altered-bone-metabolism-in-diabetes-a-narrative-review
#1
REVIEW
Maryam Ghodsi, Bagher Larijani, Abbass Ali Keshtkar, Ensieh Nasli-Esfahani, Sudabeh Alatab, Mohammad Reza Mohajeri-Tehrani
Many studies have shown that change in metabolism caused by diabetes can influence the bone metabolism in a way that quality and strength of bone is decreased. A 6 times and 2 times increased risk of fracture is reported in patients with type 1 and type 2 diabetes, respectively. There are several mechanisms by which diabetes can affect the bone. The fact that some of these mechanisms are acting in opposite ways opens the door for debate on pathways by which diabetes affects the bones. On the other hand, bone is not a simple organ that only get influence from other organs, but it is an endocrine organ that by secreting the agents such as osteocalcin, adiponectin and visfatin which can affect the insulin sensitivity and metabolism...
2016: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/27887573/in-vitro-function-of-upstream-visfatin-polymorphisms-that-are-associated-with-adverse-cardiometabolic-parameters-in-obese-children
#2
Delicia Shu Qin Ooi, Siong Gim Ong, Chew Kiat Heng, Kah Yin Loke, Yung Seng Lee
BACKGROUND: Visfatin is an adipokine associated with glucose and lipid metabolism. We previously reported two visfatin upstream single nucleotide polymorphisms (SNPs), c.-3187G > A (rs11977021) and c.-1537C > T (rs61330082), which were in perfect linkage disequilibrium, in a Singaporean cohort of severely obese children and are associated with visfatin level and adverse cardiometabolic parameters. We aim to functionally characterize the effect of c.-3187G > A and c...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27884778/expression-of-adipokines-in-osteoarthritis-osteophytes-and-their-effect-on-osteoblasts
#3
Susann Junker, Klaus W Frommer, Grit Krumbholz, Lali Tsiklauri, Rüdiger Gerstberger, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Sabine Wenisch, Georg Schett, Ulf Müller-Ladner, Elena Neumann
OBJECTIVE: Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast activity, which is -in turn- regulated by the Wnt signaling pathway. Obesity is regarded a risk factor in OA, yet little is known about the interaction between adipose tissue-derived factors, the adipokines, and bone formation, although adipokines are associated with the pathogenesis of OA. Therefore, the effect of adipokines on bone and cartilage forming cells and osteophyte development was analyzed...
November 21, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27884396/effects-of-visfatin-on-the-apoptosis-of-intestinal-mucosal-cells-in-immunological-stressed-rats
#4
Ying Zhou, Huai-Rui Yuan, Lu Cui, Abdur Rahman Ansari, Ke Xiao, You Luo, Xin-Tong Wu, Liang Guo, Faheem Ahmed Khan, Zhi Yang, Hui Song
This study was undertaken to determine if visfatin is involved in the inflammation or apoptosis introduced by LPS in rats. Forty 8-week old Wistar rats were divided into four groups (n=10 in each group) and injected with saline, visfatin, LPS and visfatin+LPS co-stimulated via caudal vein. The duodenum, jejunum and ileum were harvested from all the rats. Compared to the saline treated group, visfatin significantly increased the number of TUNEL-positive apoptotic cells and the expression of caspase-3 protein in intestinal mucosa...
November 21, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27859020/systemic-inflammation-in-acute-intermittent-porphyria-a-case-control-study
#5
E Storjord, J A Dahl, A Landsem, H Fure, J K Ludviksen, S Goldbeck-Wood, B O Karlsen, K S Berg, T E Mollnes, E W Nielsen, O-L Brekke
This study aimed to examine whether acute intermittent porphyria (AIP) is associated with systemic inflammation and whether the inflammation correlates with disease activity. A case-control study with 50 AIP cases and healthy age-, sex- and place of residence matched controls was performed. Plasma cytokines, insulin and C-peptide were analyzed after an overnight fast using multiplex assay. Long pentraxin-3 (PTX3) and complement activation products (C3bc and TCC) were analyzed using ELISA. Urine porphobilinogen ratio (U-PBG, µmol/mmol creatinine), hematological and biochemical tests were performed using routine methods...
November 8, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27843797/does-endothelial-dysfunction-correlate-with-endocrinal-abnormalities-in-patients-with-polycystic-ovary-syndrome
#6
REVIEW
Rajani Dube
To study and critically analyze the published evidence on correlation of hormonal abnormalities and endothelial dysfunction (ED) in polycystic ovary syndrome (PCOS) through a systematic review. The databases including MEDLINE, PubMed, Up-To-Date, and Science Direct were searched using Medical subject handling terms and free text term keywords such as endocrine abnormalities in PCOS, ED assessment in PCOS, ED in combination with insulin resistance (IR), hyperandrogenism (HA), increased free testosterone, free androgen index (FAI), gonadotrophin levels, luteinizing hormone (LH), prolactin, estrogen, adipocytokines to search trials, and observational studies published from January 1987 to September 2015...
October 2016: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/27813052/effects-of-metformin-on-endocrine-and-metabolic-parameters-in-patients-with-polycystic-ovary-syndrome
#7
M Zahra, M Shah, A Ali, R Rahim
The present study was designed to evaluate the effects of metformin on metabolic and endocrine parameters in patients with polycystic ovary syndrome (PCOS). The study included 40 patients with PCOS. Patients were divided into 2 groups based on whether they will receive metformin (500 mg 3 times a day, n=20) or placebo (n=20) for 3 consecutive months. Serum concentrations of fasting blood glucose, insulin, HOMA-IR, INSL-3, visfatin, FSH, and LH were measured at baseline and after 3 months of therapy. The key endocrine and metabolic parameters significantly changed after metformin treatment...
November 3, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27812515/the-effect-of-onion-peel-extract-on-inflammatory-mediators-in-korean-overweight-and-obese-women
#8
Kyung-Ah Kim, Jung-Eun Yim
Quercetin, found abundantly in onion peel, has been known to have antioxidant and anti-obesity effects and improves endothelial function. The purpose of this study was to evaluate the effects of a quercetin-rich onion peel extract (OPE) on the inflammatory mediators in overweight and obese women. This study was a randomized double-blind, placebo-controlled study. Thirty-seven healthy overweight and obese women were randomly assigned to two groups, and one group was given a soft capsuled OPE (100 mg quercetin/day, n = 18) and the other group a same capsuled placebo (n = 19) for 12 weeks...
October 2016: Clinical Nutrition Research
https://www.readbyqxmd.com/read/27809453/long-term-study-of-the-association-of-adipokines-and-glucose-variability-with-diabetic-complications
#9
Jin Joo Cha, Hye Sook Min, Kitae Kim, Mi Jin Lee, Mi Hwa Lee, Jung Eun Kim, Hye Kyoung Song, Dae Ryong Cha, Young Sun Kang
Background/Aims: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. Methods: A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and visit-to-visit glucose variability were measured in diabetic patients...
November 4, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27792999/genetic-variant-in-visfatin-gene-promoter-contributes-to-reduced-risk-of-hepatocellular-carcinoma-in-a-chinese-population
#10
Zhitong Wu, Yifan Sun, Yiyong Huang, Shengbo Zhu, Yi Feng, Huifen Ye, Chunming Liu, Shifu Tang
Knowledge on the role of gene variants in the visfatin promoter region in the hepatitis B virus (HBV)-related liver diseases is limited. In this study, we genotyped two potentially functional single nucleotide polymorphisms (SNPs) in the visfatin promoter region, -1535C>T (rs61330082) and -3187G>A (rs11977021), in 120 HBV-related chronic hepatitis B (CHB) patients, 140 HBV-related liver cirrhosis (HBV-LC) patients, 243 HBV-related hepatocellular carcinoma (HBV-HCC) patients, and 224 asymptomatic HBV carriers...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27785570/association-of-serum-microrna-21-levels-with-visfatin-inflammation-and-acute-coronary-syndromes
#11
Faramarz Darabi, Mahmoud Aghaei, Ahmad Movahedian, Armin Elahifar, Ali Pourmoghadas, Nizal Sarrafzadegan
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression. It seems that microRNA-21 (miR-21) and Visfatin, a novel adipocytokine, play roles in inflammation and atherosclerosis. The aim of this study was to investigate the association of miR-21 with Visfatin, inflammation, atherosclerosis and acute coronary syndrome (ACS). Based on coronary angiography and electrocardiogram (ECG), 53 patients with ACS and 52 patients with stable CAD were enrolled in this study. We assayed serum miR-21, Visfatin, and routine chemistries using quantitative reverse transcriptase polymerase chain reaction (QRT-PCR), enzyme-linked immunosorbent assay (ELISA) and automated analyzer, respectively...
October 26, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27770715/circulating-visfatin-level-is-associated-with-hepatocellular-carcinoma-in-chronic-hepatitis-b-or-c-virus-infection
#12
I-Ting Tsai, Chao-Ping Wang, Teng-Hung Yu, Yung-Chuan Lu, Chih-Wen Lin, Li-Fen Lu, Cheng-Ching Wu, Fu-Mei Chung, Yau-Jiunn Lee, Wei-Chin Hung, Chia-Chang Hsu
Adipocytokines play an important role in adipose tissue homeostasis, especially in obesity-associated disorders such as non-alcoholic fatty liver and their complications including hepatocellular carcinoma (HCC). Although visfatin is an adipocytokine highly expressed in visceral fat that has been demonstrated to play a critical role in the progression of human malignancies, little is known about the role of visfatin in HCC associated with chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infection...
October 19, 2016: Cytokine
https://www.readbyqxmd.com/read/27765498/myokines-and-adipokines-involvement-in-the-crosstalk-between-skeletal-muscle-and-adipose-tissue
#13
Fengna Li, Yinghui Li, Yehui Duan, Chien-An A Hu, Yulong Tang, Yulong Yin
Skeletal muscle and adipose tissue are the two largest organs in the body. Skeletal muscle is an effector organ, and adipose tissue is an organ that stores energy; in addition, they are endocrine organs that secrete cytokines, namely myokines and adipokines, respectively. Myokines consist of myostatin, interleukin (IL)-8, IL-15, irisin, fibroblast growth factor 21, and myonectin; adipokines include leptin, adiponectin, resistin, chemerin, and visfatin. Furthermore, certain cytokines, such as IL-6 and tumor necrosis factor-α, are released by both skeletal muscle and adipose tissue and exhibit a bioactive effect; thus, they are called adipo-myokines...
October 13, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27746590/from-placenta-to-polycystic-ovarian-syndrome-the-role-of-adipokines
#14
REVIEW
Chiara Sartori, Pietro Lazzeroni, Silvia Merli, Viviana Dora Patianna, Francesca Viaroli, Francesca Cirillo, Sergio Amarri, Maria Elisabeth Street
Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulating insulin sensitivity and inflammation, and have significant effects on growth and reproductive function. The objective of this review was to analyze the functions known today of adiponectin, leptin, resistin, and visfatin from placenta throughout childhood and adolescence...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27738812/regularly-consuming-a-green-roasted-coffee-blend-reduces-the-risk-of-metabolic-syndrome
#15
Beatriz Sarriá, Sara Martínez-López, José Luis Sierra-Cinos, Luis García-Diz, Raquel Mateos, Laura Bravo-Clemente
PURPOSE: Preventive health effects of coffee could have a widespread impact on public health. Green coffee has more phenols than roasted, and thus is healthier, although with less acceptable organoleptic properties. Therefore, the effects of regularly consuming a green/roasted coffee blend (35/65) on the main components of MetS in humans were evaluated. METHODS: A crossover, randomized, controlled study was performed in 25 normocholesterolaemic and 27 hypercholesterolaemic men and women aged 18-45 years with BMI 18-25 kg/m(2)...
October 13, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27712122/the-relationship-between-circulating-visfatin-nicotinamide-phosphoribosyltransferase-obesity-inflammation-and-lipids-profile-in-elderly-population-determined-by-structural-equation-modeling
#16
Aleksander J Owczarek, Magdalena Olszanecka-Glinianowicz, Piotr Kocełak, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Monika Puzianowska-Kuźnicka, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chudek
BACKGROUND: The available literature suggests that circulating visfatin/Nicotinamide Phosphoribosyltransferase (NAMPT) level variability in humans is related to obesity, insulin resistance, inflammation, and lipid profile. The aim of the study was to assess the relationship between circulating visfatin/NAMPT, obesity, insulin resistance, inflammation, and lipid profile in a large population-based, elderly cohort, applying structural equation modeling. MATERIALS AND METHODS: The analysis included 2983 elderly participants of the PolSenior study with assessed total blood count, fasting concentrations of lipids, glucose, insulin, hs-CRP, interleukin-6, and visfatin/NAMPT (by ELISA), and calculated HOMA-IR...
December 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27684733/increased-serum-leptin-and-visfatin-levels-in-patients-with-diffuse-idiopathic-skeletal-hyperostosis-a-comparative-study
#17
S Tenti, P Palmitesta, N Giordano, M Galeazzi, A Fioravanti
No abstract text is available yet for this article.
August 16, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27667744/carboxylated-and-undercarboxylated-osteocalcin-in-metabolic-complications-of-human-obesity-and-prediabetes
#18
Urszula Razny, Danuta Fedak, Beata Kiec-Wilk, Joanna Goralska, Anna Gruca, Anna Zdzienicka, Malgorzata Kiec-Klimczak, Bogdan Solnica, Alicja Hubalewska-Dydejczyk, Malgorzata Malczewska-Malec
BACKGROUND: Carboxylated osteocalcin (Gla-OC) participates in bone remodeling, whereas the undercarboxylated form (Glu-OC) takes part in energy metabolism. This study was undertaken to compare the blood levels of Glu-OC and Gla-OC in non-obese, healthy obese as well as prediabetic volunteers and correlate it with the metabolic markers of insulin resistance and early markers of inflammation. METHODS: Non-obese (BMI <30 kg/m(2) , n = 34) and obese subjects (>30 BMI <40 kg/m(2) , n = 98), both sexes, aged 25-65 years were divided into: healthy control, normal weight subjects, healthy obese and obese with biochemical markers of prediabetes and subgroups with obesity and low or high Gla-OC or Glu-OC and considered for statistical analysis...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27629533/synovial-fluid-adipokines-are-associated-with-clinical-severity-in-knee-osteoarthritis-a-cross-sectional-study-in-female-patients-with-joint-effusion
#19
Joan Calvet, Cristóbal Orellana, Jordi Gratacós, Antoni Berenguer-Llergo, Assumpta Caixàs, Juan José Chillarón, Juan Pedro-Botet, María García-Manrique, Noemí Navarro, Marta Larrosa
BACKGROUND: Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patients with knee osteoarthritis with joint effusion. METHODS: Cross-sectional study with systematic inclusion of female patients with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, physical exercise, knee osteoarthritis symptoms duration, classical cardiovascular risk factors and different anthropometric measurements were collected...
September 15, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27609490/low-birth-weight-but-not-catch-up-growth-correlates-with-insulin-resistance-and-resistin-level-in-sga-infants-at-12-months
#20
Vasileios Giapros, Efthymia Vavva, Ekaterini Siomou, Georgios Kolios, Sofia Tsabouri, Vasileios Cholevas, Eleni Bairaktari, Meropi Tzoufi, Anna Challa
OBJECTIVE: To investigate the insulin resistance status in SGA infants at 12 months and its relationship with auxological and metabolic parameters. METHODS: One group of 45 SGA and one of 50 appropriate for gestational age infants were followed from birth to the end of the first year of life. At 12 months, skinfold thickness, waist circumference, and blood levels of glucose, insulin, adiponectin, leptin, resistin, visfatin, retinol-binding protein 4, IGFs, lipids profile were determined, and the HOMA-IR index was calculated...
September 9, 2016: Journal of Maternal-fetal & Neonatal Medicine
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