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https://www.readbyqxmd.com/read/28635510/the-effects-on-obesity-related-peptides-of-laparoscopic-gastric-band-applications-in-morbidly-obese-patients
#1
Pinar Cigdem Arica, Seval Aydin, Ulgen Zengin, Ahmet Kocael, Anil Orhan, Kagan Zengin, Remise Gelisgen, Mustafa Taskin, Hafize Uzun
BACKGROUND: The aim of this study was to examine the relationship between weight loss and resistin, apelin, chemerin, and visfatin after laparoscopic adjustable gastric banding (LAGB). METHODS: The study group consisted of 19 patients who were operated on for morbid obesity (BMI: 48.7 ± 6.6 kg/m(2)), and 22 healthy, normal-weight (BMI: 22.9 ± 2.5 kg/m(2)) subjects formed the control group. We obtained blood samples from the study subjects at three different times: before undergoing surgery and at one month and 6 months after surgery...
February 10, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28619118/serum-levels-of-leptin-and-high-molecular-weight-adiponectin-are-inversely-associated-with-radiographic-spinal-progression-in-patients-with-ankylosing-spondylitis-results-from-the-enradas-trial
#2
Agnes Hartl, Joachim Sieper, Uta Syrbe, Joachim Listing, Kay-Geert Hermann, Martin Rudwaleit, Denis Poddubnyy
BACKGROUND: Previous research indicates a role of adipokines in inflammation and osteogenesis. Hence adipokines might also have a pathophysiological role in inflammation and new bone formation in patients with ankylosing spondylitis (AS). The aim of this study was to investigate the role of adipokine serum levels as predictors of radiographic spinal progression in patients with AS. METHODS: A total of 120 patients with definite AS who completed a 2-year follow up in the ENRADAS trial were included in the current study...
June 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28604943/adipokine-profile-in-patients-with-anorexia-nervosa
#3
Agnieszka Baranowska-Bik, Bogusława Baranowska, Lidia Martyńska, Anna Litwiniuk, Małgorzata Kalisz, Jan Kochanowski, Wojciech Bik
INTRODUCTION: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissue-derived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. MATERIAL AND METHODS: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls...
June 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28585201/the-pathogenesis-of-obesity-associated-adipose-tissue-inflammation
#4
Atilla Engin
Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive fatty acid release may worsen adipose tissue inflammation and contributes to insulin resistance. In this case, several novel and highly active molecules are released abundantly by adipocytes like leptin, resistin, adiponectin or visfatin, as well as some more classical cytokines. Most likely cytokines that are released by inflammatory cells infiltrating obese adipose tissue are such as tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1) (CCL-2) and IL-1...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28562326/the-association-between-obesity-related-adipokines-and-risk-of-breast-cancer-a-systematic-review-and-meta-analysis
#5
Yu Gui, Qingwen Pan, Xianchun Chen, Shuman Xu, Xiangdong Luo, Li Chen
The risk of breast cancer is significantly increased among obese women as the deleterious adipokines can be over secreted and beneficial adipokines can be hyposecreted. We aim to evaluate the association between obesity-associated adipokines and breast cancer. We searched PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature (CBM) databases for studies reporting association of obesity related adipokines with breast cancer published before Sept. 15, 2015. Initially, 26783 publications were identified, and later, 119 articles were selected for further meta-analysis...
May 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28553078/effects-of-metformin-extended-release-compared-to-immediate-release-formula-on-glycemic-control-and-glycemic-variability-in-patients-with-type-2-diabetes
#6
Giuseppe Derosa, Angela D'Angelo, Davide Romano, Pamela Maffioli
PURPOSE: The purpose of this study is to evaluate, in a randomized clinical trial, the effects of metformin immediate release (IR) compared with metformin extended release (XR) on the gastrointestinal tolerability and glycemic control. MATERIALS AND METHODS: We enrolled 253 Caucasian patients with type 2 diabetes not well controlled by diet (glycated hemoglobin [HbA1c] >7.0% and <8.5%). Patients were randomized to metformin IR or metformin XR for a period of 6 months at the maximum tolerated dose...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28552966/even-and-odd-chain-saturated-fatty-acids-in-serum-phospholipids-are-differentially-associated-with-adipokines
#7
Kayo Kurotani, Masao Sato, Kazuki Yasuda, Kentaro Kashima, Shoji Tanaka, Takuya Hayashi, Bungo Shirouchi, Shamima Akter, Ikuko Kashino, Hitomi Hayabuchi, Tetsuya Mizoue
BACKGROUND: Saturated fatty acids are generally thought to have detrimental effects on health. However, a recent study showed that even- and odd-chain saturated fatty acids had opposite associations with type 2 diabetes. Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism. OBJECTIVE: We examined the associations of saturated fatty acids in serum phospholipids with circulating levels of adipokines among a Japanese population...
2017: PloS One
https://www.readbyqxmd.com/read/28535646/-the-research-advances-in-the-relationship-between-visfatin-and-cancer
#8
W Y Tian, Y M Wang, Y F Zhang, F X Xue
Visfatin is a cytokine secreted by visceral adipose tissue, which plays an important role in obesity, diabetes, insulin resistance, atherosclerosis and polycystic ovarian syndrome. Additionally, visfatin is also involved in the metabolic syndrome-associated malignancies such as breast, colon, gastric and endometrial cancers. Visfatin inhibitor might be a potential antitumor therapeutic strategy for inhibiting the growth of many cancers.
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28507632/visfatin-versus-flow-mediated-dilatation-as-a-marker-of-endothelial-dysfunction-in-pediatric-renal-transplant-recipients
#9
Fatina Fadel, Hafez M Bazraa, Safaa M Abdelrahman, Mohamed Gamal Shouman, Marwa Khaled Sayed, Doaa Mohamed Salah, Aliaa Ahmed Wahby, Heba F Elgebaly
BACKGROUND: Renal transplantation (RTx) is the treatment of choice for paediatric end-stage renal disease (ESRD). A major cause of morbidity and mortality after RTx is cardiovascular disease. Independent predictors of cardiovascular events were shown to constitute an endothelial dysfunction (ED). This study aims to evaluate Visfatin serum level in comparison to brachial artery flow-mediated dilatation (FMD) as a marker of endothelial dysfunction in paediatric RTx recipients. METHODS: Visfatin serum level has been evaluated in 30 patients on regular hemodialysis (HD), 36 patients post-RTx and 30 controls as a measure for ED, and has been compared to brachial artery FMD...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28485496/curcumin-a-naturally-occurring-modulator-of-adipokines-in-diabetes
#10
Jafar Hajavi, Amir Abbas Momtazi, Thomas P Johnston, Maciej Banach, Muhammed Majeed, Amirhossein Sahebkar
Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokines, and adipokines. Disturbed regulation of adipokines, which include adiponectin, leptin, resistin, and visfatin, are implicated in the development of insulin resistance and Type 2 Diabetes. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects that curcumin treatment exerts on adipokines...
May 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28482725/umbilical-cord-blood-and-maternal-visfatin-pbef-nampt-concentrations-in-preterm-birth-with-and-without-preterm-premature-rupture-of-membranes
#11
Tereza Pavlová, Filip Zlámal, Zbyněk Šplíchal, Josef Tomandl, Zuzana Hodická, Pavel Ventruba, Julie Bienertová-Vašků
OBJECTIVES: The aim of the study is to investigate differences in visfatin concentrations between mothers with term and preterm birth (PTB) and between mothers who delivered within 7 days and after more than 7 days following admission for PTB/preterm premature rupture of membranes (PPROM). METHODS: Maternal peripheral blood and cord blood was collected from 56 mothers with PTB (31 with PPROM) and 71 mothers with term delivery (3 with PPROM). RESULTS: Maternal visfatin concentration was significantly higher for given gestational age in PTBs compared to term deliveries (p = 0...
May 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28478800/hif-1%C3%AE-mediates-visfatin-induced-ctgf-expression-in-vascular-endothelial-cells
#12
W Wu, J Li, M Zhao, X Liu
Visfatin is an adipokine that functions as a mediator of endothelial dysfunction and cardiovascular diseases. Connective tissue growth factor (CTGF) is a key factor in vascular remodeling and atherosclerosis. However, the association between visfatin and CTGF is unclear. Therefore the study was to test the hypothesis that visfatin could modulate the expression of CTGF in vascular endothelial cells. In our study, cultured endothelial cell line EA.Hy926 cells were treated with different concentrations of visfatin for different times...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28442350/extracellular-nampt-visfatin-induces-proliferation-through-erk1-2-and-akt-and-inhibits-apoptosis-in-breast-cancer-cells
#13
Zafar Gholinejad, Nejat Kheiripour, Mitra Nourbakhsh, Davod Ilbeigi, Kiarash Behroozfar, Zahra Hesari, Abolfazl Golestani, Mohammad Shabani, Nahid Einollahi
BACKGROUND: Visfatin is a novel adipokine and proinflammatory cytokine which is implicated in breast cancer progression. The exact proliferative and anti-apoptotic mechanisms of visfatin are still under debate. In this study, the effect of extracellular visfatin on proliferation and apoptosis of breast cancer cells were investigated considering key regulatory molecules in these procedures. METHODS: BrdU (Bromodeoxyuridine) experiment was used to assess cell proliferation in response to visfatin treatment...
April 23, 2017: Peptides
https://www.readbyqxmd.com/read/28420006/increased-visfatin-expression-is-associated-with-nuclear-factor-kappa-%C3%AE-in-obese-ovalbumin-sensitized-male-wistar-rats-trachea
#14
Mohammad Reza Aslani, Rana Keyhanmanesh, Mohammad Reza Alipour
OBJECTIVE: To investigate the effects of diet-induced obesity on the expression of nuclear factor-kappa β and visfatin messenger RNA in male Wistar rats' tracheae after sensitization with ovalbumin (OVA). MATERIALS AND METHODS: Twenty (20) male Wistar rats were divided into four groups (n=5 for each group), that included a control fed normal diet (ND), and fed normal diet OVA-sensitized (S+ND), high-fat diet (HFD) only, (diet induced obesity) and high-fat diet OVA-sensitized (S+HFD)...
April 16, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28416270/plasma-levels-and-leucocyte-rna-expression-of-adipokines-in-young-patients-with-coronary-artery-disease-in-metabolic-syndrome-and-healthy-controls
#15
Aleš Smékal, Jan Václavík, David Stejskal, Klára Benešová, Jiří Jarkovský, Gabriela Svobodová, Radmila Richterová, Marek Švesták, Miloš Táborský
OBJECTIVES: Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic syndrome and healthy individuals. DESIGN AND METHODS: Sixty-five patients with premature CAD (men 18-45years old and women 18-55years old) formed the study group...
April 14, 2017: Cytokine
https://www.readbyqxmd.com/read/28406695/visfatin-is-actively-secreted-in-vitro-from-u-937-macrophages-but-only-passively-released-from-3t3-l1-adipocytes-and-hepg2-hepatocytes
#16
P Svoboda, E KříŽová, K Čeňková, K Vápenková, J Zídková, V Zídek, V Škop
Visfatin is a multi-functional molecule that can act intracellularly and extracellularly as an adipokine, cytokine and enzyme. One of the main questions concerning visfatin is the mechanism of its secretion; whether, how and from which cells visfatin is released. The objective of this in vitro study was to observe the active secretion of visfatin from 3T3-L1 preadipocytes and adipocytes, HepG2 hepatocytes, U-937, THP-1 and HL-60 monocytes and macrophages. The amount of visfatin in media and cell lysate was always related to the intracellular enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), to exclude the passive release of visfatin...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28402255/chemotherapy-and-plasma-adipokines-level-in-patients-with-colorectal-cancer
#17
Grzegorz Słomian, Elżbieta Świętochowska, Grzegorz Nowak, Krystyna Pawlas, Aleksandra Żelazko, Przemysław Nowak
Adipokines are molecules produced and secreted by adipose tissue and are linked to multiple malignancies. Adipokines can suppress or promote particular cell behaviors in different types of cancer. The aim of this study was to investigate the impact of chemotherapy on select adipokines in patients with colorectal cancer (CRC). Blood samples were collected from 42 patients with pathologically documented advanced CRC, who required palliative chemotherapy. Leptin, adiponectin, resistin and visfatin levels were measured by ELISA before and 3 months after the administration of chemotherapy...
April 12, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28399156/presence-of-il-17-in-synovial-fluid-identifies-a-potential-inflammatory-osteoarthritic-phenotype
#18
Sarah J B Snelling, Sylvette Bas, Gabor J Puskas, Stephanie G Dakin, Domizio Suva, Axel Finckh, Cem Gabay, Pierre Hoffmeyer, Andrew J Carr, Anne Lübbeke
PURPOSE: Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients suffer pain and their joints are characterized by articular cartilage loss and osteophyte formation. Risk factors for OA include age and obesity with inflammation identified as a key mediator of disease pathogenesis. Interleukin-17A (IL-17) is a pro-inflammatory cytokine that has been implicated in inflammatory diseases such as rheumatoid arthritis. IL-17 can upregulate expression of inflammatory cytokines and adipocytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28389056/effects-of-adipokines-and-obesity-on-uterine-contractility
#19
REVIEW
Henri Azaïs, Audrey Leroy, Louise Ghesquiere, Philippe Deruelle, Sandy Hanssens
Obesity is a major public health problem. The prevalence of obesity has significantly increased in developed countries, particularly in France with an overall increase of 76% over the last 15 years. In pregnant women, obesity is associated with alterations in the quality of labor, such as delayed onset of labor, a higher rate of prolonged pregnancies, prolonged labor, and higher oxytocin requirements. There is also an increased prevalence of Cesarean sections, particularly during the active phase of labor, and perinatal complications (postpartum hemorrhage)...
January 13, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28348585/the-determinants-of-leptin-levels-in-diabetic-and-nondiabetic-saudi-males
#20
Mona Hmoud Al Sheikh
Objective. This study aimed to identify the main determinants of serum leptin levels. Methods. A sample of 113 Saudi adult males (55 diabetic and 58 nondiabetic) was selected according to the inclusion and exclusion criteria identified below. Blood samples were taken from participants after fasting for 12 hours. For diabetic patients, the insulin dose was given 12 hours before. In general, the study instrument consisted of blood biochemical tests. Metabolic parameters, glycosylated hemoglobin (HbA1c), low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, and triglyceride (TG), and adipokines, leptin, adiponectin, visfatin, and resistin, were measured...
2017: International Journal of Endocrinology
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