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Peripheral nerve injury

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https://www.readbyqxmd.com/read/29351125/central-inhibition-of-granulocyte-macrophage-colony-stimulating-factor-is-analgesic-in-experimental-neuropathic-pain
#1
Louise S C Nicol, Peter Thornton, Jon P Hatcher, Colin P Glover, Carl I Webster, Matthew Burrell, Kessia Hammett, Clare A Jones, Matthew A Sleeman, Andrew Billinton, Iain Chessell
With less than 50% of patients responding to the current standard of care and poor efficacy and selectivity of current treatments, neuropathic pain continues to be an area of considerable unmet medical need. Biological therapeutics such as monoclonal antibodies (mAbs) provide better intrinsic selectivity; however, delivery to the central nervous system (CNS) remains a challenge. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is well described in inflammation-induced pain, and early-phase clinical trials evaluating its antagonism have exemplified its importance as a peripheral pain target...
January 16, 2018: Pain
https://www.readbyqxmd.com/read/29350602/a-novel-approach-to-32-channel-peripheral-nervous-system-myelin-imaging-in-vivo-with-single-axon-resolution
#2
Joey Grochmal, Wulin Teo, Hardeep Gambhir, Ranjan Kumar, Jo Anne Stratton, Raveena Dhaliwal, Craig Brideau, Jeff Biernaskie, Peter K Stys, Rajiv Midha
OBJECTIVE Intravital spectral imaging of the large, deeply situated nerves in the rat peripheral nervous system (PNS) has not been well described. Here, the authors have developed a highly stable platform for performing imaging of the tibial nerve in live rodents, thus allowing the capture of high-resolution, high-magnification spectral images requiring long acquisition times. By further exploiting the qualities of the topically applied myelin dye Nile red, this technique is capable of visualizing the detailed microenvironment of peripheral nerve demyelination injury and recovery, while allowing us to obtain images of exogenous Schwann cell myelination in a living animal...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29350067/soluble-neuregulin1-is-strongly-up-regulated-in-the-rat-model-of-charcot-marie-tooth-1a-disease
#3
Benedetta Elena Fornasari, Giulia Ronchi, Davide Pascal, Davide Visigalli, Giovanna Capodivento, Lucilla Nobbio, Isabelle Perroteau, Angelo Schenone, Stefano Geuna, Giovanna Gambarotta
Neuregulin1 (NRG1) is a growth factor playing a pivotal role in peripheral nerve development through the activation of the transmembrane co-receptors ErbB2-ErbB3. Soluble NRG1 isoforms, mainly secreted by Schwann cells, are strongly and transiently up-regulated after acute peripheral nerve injury, thus suggesting that they play a crucial role also in the response to nerve damage. Here we show that in the rat experimental model of the peripheral demyelinating neuropathy Charcot-Marie-Tooth 1A (CMT1A) the expression of the different NRG1 isoforms (soluble, type α and β, type a and b) is strongly up-regulated, as well as the expression of NRG1 co-receptors ErbB2-ErbB3, thus showing that CMT1A nerves have a gene expression pattern highly reminiscent of injured nerves...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29349574/pacific-ciguatoxin-induces-excitotoxicity-and-neurodegeneration-in-the-motor-cortex-via-caspase-3-activation-implication-for-irreversible-motor-deficit
#4
Pallavi Asthana, Ni Zhang, Gajendra Kumar, Virendra Bhagawan Chine, Kunal Kumar Singh, Yim Ling Mak, Leo Lai Chan, Paul Kwan Sing Lam, Chi Him Eddie Ma
Consumption of fish containing ciguatera toxins or ciguatoxins (CTXs) causes ciguatera fish poisoning (CFP). In some patients, CFP recurrence occurs even years after exposure related to CTXs accumulation. Pacific CTX-1 (P-CTX-1) is one of the most potent natural substances known that causes predominantly neurological symptoms in patients; however, the underlying pathogenies of CFP remain unknown. Using clinically relevant neurobehavioral tests and electromyography (EMG) to assess effects of P-CTX-1 during the 4 months after exposure, recurrent motor strength deficit occurred in mice exposed to P-CTX-1...
January 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29346771/rapid-turnover-of-cortical-ncam1-regulates-synaptic-reorganization-after-peripheral-nerve-injury
#5
Hyoung-Gon Ko, Jun-Hyeok Choi, Dong Ik Park, SukJae Joshua Kang, Chae-Seok Lim, Su-Eon Sim, Jaehoon Shim, Ji-Il Kim, Siyong Kim, Tae-Hyeok Choi, Sanghyun Ye, Jaehyun Lee, Pojeong Park, Somi Kim, Jeehaeh Do, Jihye Park, Md Ariful Islam, Hyun Jeong Kim, Christoph W Turck, Graham L Collingridge, Min Zhuo, Bong-Kiun Kaang
Peripheral nerve injury can induce pathological conditions that lead to persistent sensitized nociception. Although there is evidence that plastic changes in the cortex contribute to this process, the underlying molecular mechanisms are unclear. Here, we find that activation of the anterior cingulate cortex (ACC) induced by peripheral nerve injury increases the turnover of specific synaptic proteins in a persistent manner. We demonstrate that neural cell adhesion molecule 1 (NCAM1) is one of the molecules involved and show that it mediates spine reorganization and contributes to the behavioral sensitization...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346752/epitranscriptomic-m6a-regulation-of-axon-regeneration-in-the-adult-mammalian-nervous-system
#6
Yi-Lan Weng, Xu Wang, Ran An, Jessica Cassin, Caroline Vissers, Yuanyuan Liu, Yajing Liu, Tianlei Xu, Xinyuan Wang, Samuel Zheng Hao Wong, Jessica Joseph, Louis C Dore, Qiang Dong, Wei Zheng, Peng Jin, Hao Wu, Bin Shen, Xiaoxi Zhuang, Chuan He, Kai Liu, Hongjun Song, Guo-Li Ming
N6-methyladenosine (m6A) affects multiple aspects of mRNA metabolism and regulates developmental transitions by promoting mRNA decay. Little is known about the role of m6A in the adult mammalian nervous system. Here we report that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG). Single-base resolution m6A-CLIP mapping further reveals a dynamic m6A landscape in the adult DRG upon injury...
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29345353/hipop-mesenchymal-population-has-high-potential-for-repairing-injured-peripheral-nerves
#7
Yukako Yamauchi, Shousaku Itoh, Haruna Naruse, Yuki Itoh, Makoto Abe, Takumi Kagioka, Mikako Hayashi
Bone marrow stromal cells (BMSCs) are reportedly a heterogeneous population of mesenchymal stem cells (MSCs). Recently, we developed a simple strategy for the enrichment of MSCs with the capacity to differentiate into osteoblasts, chondrocytes, and adipocytes. On transplantation, the progenitor-enriched fractions can regenerate the bone with multiple lineages of donor origin and are thus called "highly purified osteoprogenitors" (HipOPs). Although our previous studies have demonstrated that HipOPs are enriched with MSCs and exhibit a higher potential to differentiate into osteoblasts, adipocytes, and chondrocytes than BMSCs, their potential to differentiate into neural cells has not been clarified...
January 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29343415/paradigms-for-restoration-of-somatosensory-feedback-via-stimulation-of-the-peripheral-nervous-system
#8
REVIEW
Cristian Pasluosta, Patrick Kiele, Thomas Stieglitz
The somatosensory system contributes substantially to the integration of multiple sensor modalities into perception. Tactile sensations, proprioception and even temperature perception are integrated to perceive embodiment of our limbs. Damage of somatosensory networks can severely affect the execution of daily life activities. Peripheral injuries are optimally corrected via direct interfacing of the peripheral nerves. Recent advances in implantable devices, stimulation paradigms, and biomimetic sensors enabled the restoration of natural sensations after amputation of the limb...
December 27, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29341457/different-effects-of-dexmedetomidine-and-midazolam-on-the-expression-of-nr2b-and-gabaa-%C3%AE-1-following-peripheral-nerve-injury-in-rats
#9
Jiayu Chen, Hanjun Li, Grewo Lim, Michael F McCabe, Wei Zhao, Yunli Yang, Weiqing Ma, Na Li
Neuropathic pain is a complex, chronic pain condition and the treatment is a major clinical challenge. Recent studies have shown that two FDA approved drugs dexmedetomidine (DEX) and midazolam (MZL), may be useful in treating neuropathic pain, but the mechanism is not fully dementated. Here, we investigated the effects and mechanisms of DEX and MZL treatment in the peripheral nerve injury model. Intramuscular injection with DEX and MZL attenuated the development of mechanical allodynia and thermal hyperalgesia in rats with chronic constriction injury (CCI)...
January 17, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29340845/dihydrotestosterone-treatment-accelerates-autograft-reversal-sciatic-nerve-regeneration-in-rats
#10
Xiaofan Yang, Pingping Xue, Ruozheng Wei, Xin Liu, Xiang Xu, Zhenyu Liu, Yanhua Chen, Zhenbing Chen
Neuroactive steroids such as progesterone, testosterone, and their derivatives have been widely studied for their neuroprotective roles in the nervous system. Autologous nerve transplantation is considered as the gold standard repair technique when primary suture is impossible; nevertheless, this method is far from ideal. In this study, we aimed to explore the impact of dihydrotestosterone (DHT), a 5α-reduced derivative of testosterone, on the recovery of peripheral nerve injury treated with autologous nerve transplantation...
January 16, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29335507/highly-conserved-molecular-pathways-including-wnt-signaling-promote-functional-recovery-from-spinal-cord-injury-in-lampreys
#11
Paige E Herman, Angelos Papatheodorou, Stephanie A Bryant, Courtney K M Waterbury, Joseph R Herdy, Anthony A Arcese, Joseph D Buxbaum, Jeramiah J Smith, Jennifer R Morgan, Ona Bloom
In mammals, spinal cord injury (SCI) leads to dramatic losses in neurons and synaptic connections, and consequently function. Unlike mammals, lampreys are vertebrates that undergo spontaneous regeneration and achieve functional recovery after SCI. Therefore our goal was to determine the complete transcriptional responses that occur after SCI in lampreys and to identify deeply conserved pathways that promote regeneration. We performed RNA-Seq on lamprey spinal cord and brain throughout the course of functional recovery...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331319/a-histopathological-and-biochemical-evaluation-of-oxidative-injury-in-the-sciatic-nerves-of-male-rats-exposed-to-a-continuous-900-megahertz-electromagnetic-field-throughout-all-periods-of-adolescence
#12
Gökçen Kerimoğlu, Canan Güney, Şafak Ersöz, Ersan Odacı
The effects on human health of the electromagnetic field (EMF) emitted by mobile phones, used by approximately 7 billion people worldwide, have become an important subject for scientific research. Studies have suggested that the EMF emitted by mobile phones can cause oxidative stress in different tissues and age groups. Young people in adolescence, a time period when risky behaviors and dependences increase, use mobile phones more than adults. The EMF emitted by mobile phones, which are generally carried in the pocket or in bags when not in use, will very probably affect the sciatic nerve...
January 10, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29331040/jun-gal-cd74-and-c1qb-as-potential-indicator-for-neuropathic-pain
#13
Ji-An Yang, Jun-Min He, Jing-Min Lu, Li-Juan Ji
Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sham operation model. Microarray and the spared nerve injury module were used to explore the molecular mechanism of neuropathic pain by injuries and the differentially expressed genes (DEGs) were identified out...
January 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29330414/partially-oxidized-polyvinyl-alcohol-conduitfor-peripheral-nerve-regeneration
#14
Elena Stocco, Silvia Barbon, Lucia Lora, Francesca Grandi, Leonardo Sartore, Cesare Tiengo, Lucia Petrelli, Daniele Dalzoppo, Pier Paolo Parnigotto, Veronica Macchi, Raffaele De Caro, Andrea Porzionato, Claudio Grandi
Surgical reconstruction of peripheral nerves injuries with wide substance-loss is still a challenge. Many studies focused on the development of artificial nerve conduits made of synthetic or biological materials but the ideal device has not yet been identified. Here, we manufactured a conduit for peripheral nerve regeneration using a novel biodegradable hydrogel we patented that is oxidized polyvinyl alcohol (OxPVA). Thus, its characteristics were compared with neat polyvinyl alcohol (PVA) and silk-fibroin (SF) conduits, through in vitro and in vivo analysis...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330037/sustained-delivery-of-glial-cell-derived-neurotrophic-factors-in-collagen-conduits-for-facial-nerve-regeneration
#15
Fukai Ma, Feng Xu, Ronggang Li, Yongtao Zheng, Fan Wang, Naili Wei, Junjie Zhong, Qisheng Tang, Tongming Zhu, Zhifu Wang, Jianhong Zhu
Facial nerve injury caused by traffic accidents or operations may reduce the quality of life in patients, and recovery following the injury presents unique clinical challenges. Glial cell-derived neurotrophic factor (GDNF) is important in nerve regeneration; however, soluble GDNF rapidly diffuses into body fluids, making it difficult to achieve therapeutic efficacy. In this work, we developed a rat tail derived collagen conduit to connect nerve defects in a simple and safe manner. GDNF was immobilized in the collagen conduits via chemical conjugation to enable controlled release of GDNF...
January 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29328516/ultrasonographic-demonstration-of-intraneural-neovascularization-after-penetrating-nerve-injury
#16
Zsuzsanna Arányi, Anita Csillik, Katalin Dévay, Maja Rosero
INTRODUCTION: Hypervascularization of nerves has been shown to be a pathological sign in some peripheral nerve disorders, but has not been investigated in nerve trauma. METHODS: An observational cohort study was performed of the intraneural blood flow of 30 patients (34 nerves) with penetrating nerve injuries, before or after nerve reconstruction. All patients underwent electrophysiological assessment, and B-mode and color Doppler ultrasonography. RESULTS: Intraneural hypervascularization proximal to the site of injury was found in all nerves, which was typically marked and had a longitudinal extension of several centimeters...
January 12, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29328458/chitosan-conduit-combined-with-hyaluronic-acid-prevent-sciatic-nerve-scar-in-a-rat-model-of-peripheral-nerve-crush-injury
#17
Runxin Li, Huawei Liu, Haitao Huang, Wenting Bi, Rongzeng Yan, Xinying Tan, Weisheng Wen, Chao Wang, Wenling Song, Yanhua Zhang, Feng Zhang, Min Hu
In the present study, the effects of hyaluronic acid (HA) combined with chitosan conduit on peripheral nerve scarring and regeneration were investigated in a rat model of peripheral nerve crush injury. A total of 60 Sprague-Dawley rats were randomly distributed into four groups (15 rats in each group), in which the nerve was either not treated (control group) or treated with chitosan conduit, hyaluronic acid, or chitosan conduit coupled with hyaluronic acid following clamp injury to the sciatic nerve. The surgical sites were evaluated by assessing the sciatic functional index, the degree of scar adhesions, the numbers of myelinated nerve fibers, the average diameter of myelinated nerve fibers and the myelin sheath thickness...
January 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327966/ocular-histomorphometry-of-free-living-common-kestrels-falco-tinnunculus
#18
Karin Werther, Cinthia Graziela Candioto, Rüdiger Korbel
We evaluated the histomorphometry of the eye structures (cornea, retina, choroid, and sclera) of 13 adult free-living common kestrels ( Falco tinnunculus). Birds included in the study were euthanatized because of severe trauma from a motor vehicle injury. The eyes were enucleated immediately after euthanasia, fixed in 10% buffered formalin, and decalcified. The right eyes were cut vertically (dorsoventrally) and the left eyes cut horizontally (temporonasally). Tissues were processed, stained with hematoxylin and eosin, and evaluated by an image analysis software...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29327509/proteomic-expression-profile-of-injured-rat-peripheral-nerves-revealed-biological-networks-and-processes-associated-with-nerve-regeneration
#19
D Vergara, A Romano, E Stanca, V La Pesa, A L Aloisi, S De Domenico, J Franck, I Cicalini, A M Giudetti, E Storelli, D Pieragostino, I Fournier, A Sannino, M Salzet, F Cerri, A Quattrini, M Maffia
Peripheral nerve regeneration is regulated through the coordinated spatio-temporal activation of multiple cellular pathways. In this work, an integrated proteomics and bioinformatics approach was employed to identify differentially expressed proteins at the injury-site of rat sciatic nerve at 20 days after damage. By a label-free liquid chromatography mass-spectrometry (LC-MS/MS) approach, we identified 201 differentially proteins that were assigned to specific canonical and disease and function pathways. These include proteins involved in cytoskeleton signaling and remodeling, acute phase response, and cellular metabolism...
January 12, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29327452/regenerative-effects-of-human-embryonic-stem-cell-derived-neural-crest-cells-for-treatment-of-peripheral-nerve-injury
#20
Iwan Jones, Liudmila N Novikova, Lev N Novikov, Monika Renardy, Andreas Ullrich, Mikael Wiberg, Leif Carlsson, Paul J Kingham
Surgical intervention is the current gold standard treatment following peripheral nerve injury. However, this approach has limitations and full recovery of both motor and sensory modalities often remains incomplete. The development of artificial nerve grafts that either complement or replace current surgical procedures is therefore of paramount importance. An essential component of artificial grafts are biodegradable conduits and transplanted cells that provide trophic support during the regenerative process...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
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