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https://www.readbyqxmd.com/read/29449099/cost-of-goods-sold-and-total-cost-of-delivery-for-oral-and-parenteral-vaccine-packaging-formats
#1
Jeff Sedita, Stefanie Perrella, Matt Morio, Michael Berbari, Jui-Shan Hsu, Eugene Saxon, Courtney Jarrahian, Annie Rein-Weston, Darin Zehrung
Despite limitations of glass packaging for vaccines, the industry has been slow to implement alternative formats. Polymer containers may address many of these limitations, such as breakage and delamination. However, the ability of polymer containers to achieve cost of goods sold (COGS) and total cost of delivery (TCOD) competitive with that of glass containers is unclear, especially for cost-sensitive low- and lower-middle-income countries. COGS and TCOD models for oral and parenteral vaccine packaging formats were developed based on information from subject matter experts, published literature, and Kenya's comprehensive multiyear plan for immunization...
February 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29444764/clinical-radiological-pathological-correlation-in-an-unusual-case-of-refractory-epilepsy-a-two-year-journey-of-whodunit
#2
Deepak Menon, Ramshekhar N Menon, Chandrasekharan Kesavadas, Anita Mahadevan, Ashalatha Radhakrishnan, Sudheeran Kannoth, Pradeep P Nair, Mathew Abraham, Bejoy Thomas, Sanjeev V Thomas
New-onset refractory focal epilepsy poses significant challenges to the clinician in the absence of specific diagnostic biomarkers. Differential diagnoses based on imaging may be expanded by a veritable spectrum of peri-ictal imaging findings that may mask the underlying substrate. We report a 13-year-old girl who presented with refractory focal seizures of left parieto-occipital origin with cytotoxic gyral oedema noted over the same region on imaging. Despite an initial negative autoantibody profile, the patient was treated with immunosuppression, followed by serial relapses requiring immune-modulation...
February 14, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29444331/validation-of-the-acr-eular-criteria-for-primary-sj%C3%A3-gren-s-syndrome-in-a-dutch-prospective-diagnostic-cohort
#3
Jolien F van Nimwegen, Martha S van Ginkel, Suzanne Arends, Erlin A Haacke, Bert van der Vegt, Nicole Sillevis Smitt-Kamminga, Fred K L Spijkervet, Frans G M Kroese, Alja J Stel, Elisabeth Brouwer, Arjan Vissink, Hendrika Bootsma
Objectives: To validate the ACR-EULAR classification criteria for primary SS (pSS), and compare them to the American-European Consensus Group (AECG) and ACR criteria in a Dutch prospective diagnostic cohort. Methods: Consecutive patients (n = 129) referred for suspicion of pSS underwent a multidisciplinary evaluation, including a labial and/or parotid gland biopsy. Patients with an incomplete work-up (n = 8) or associated systemic auto-immune disease (n = 7) were excluded...
February 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29439690/a-systematic-review-of-the-effects-of-acupuncture-on-xerostomia-and-hyposalivation
#4
Zainab Assy, Henk S Brand
BACKGROUND: Saliva is fundamental to our oral health and our well-being. Many factors can impair saliva secretion, such as adverse effects of prescribed medication, auto-immune diseases (for example Sjögren's syndrome) and radiotherapy for head and neck cancers. Several studies have suggested a positive effect of acupuncture on oral dryness. METHODS: Pubmed and Web of Science were electronically searched. Reference lists of the included studies and relevant reviews were manually searched...
February 13, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29432774/pstpip1-controls-immune-synapse-stability-in-human-t-cells
#5
W J M Janssen, V Grobarova, J Leleux, C H Jongeneel, M van Gijn, J M van Montfrans, M Boes
BACKGROUND: PSTPIP1 is a cytosolic adaptor protein involved with T-cell activation, differentiation, and migration. Upon cognate T-cell contact, PSTPIP1 is recruited to surface-expressed CD2, where it regulates f-actin remodeling. An immune synapse (IS) is thereby rapidly formed, consisting of TCR clusters surrounded by a ring of adhesion molecules including CD2. OBJECTIVE: From genetic screening of primary immunodeficiency patients, we identified two mutations in PSTPIP1, R228C and T274M which we further characterized in primary patient T-cells...
February 9, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29432186/adaptive-antibody-diversification-through-n-linked-glycosylation-of-the-immunoglobulin-variable-region
#6
Fleur S van de Bovenkamp, Ninotska I L Derksen, Pleuni Ooijevaar-de Heer, Karin A van Schie, Simone Kruithof, Magdalena A Berkowska, C Ellen van der Schoot, Hanna IJspeert, Mirjam van der Burg, Ann Gils, Lise Hafkenscheid, René E M Toes, Yoann Rombouts, Rosina Plomp, Manfred Wuhrer, S Marieke van Ham, Gestur Vidarsson, Theo Rispens
A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually defined in terms of amino acid composition. However, variable domains may also acquire N -linked glycans, a process conditional on the introduction of consensus amino acid motifs ( N -glycosylation sites) during somatic hypermutation. High levels of variable domain glycans have been associated with autoantibodies in rheumatoid arthritis, as well as certain follicular lymphomas...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29430979/an-effective-treatment-approach-of-dpp-iv-inhibitor-encapsulated-polymeric-nano-particles-conjugated-with-anti-cd-4-mab-for-type-1-diabetes
#7
Mahesh Thondawada, Ashish Devidas Wadhwani, Dhanabal S Palanisamy, Hanumant Singh Rathore, Ramesh C Gupta, Pavan Kumar Chintamaneni, Malay K Samanta, Anil Dubala, Sameer Varma, Praveen T Krishnamurthy, Kuppusamy Gowthamarajan
Nanotechnology based bio-medical approaches and surface modification techniques made it easier for targeting specific site and improving the treatment efficacy. The present study reports on targeted polymeric nanoparticles conjugated with antibody as a site-specific carrier system for effective treatment of Type 1 diabetes. Sitagliptin (SP) loaded Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NP) were prepared by nanoprecipitation cum solvent evaporation method and were characterized in terms of morphology, size, surface charge and entrapment efficiency...
February 12, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29427827/nailfold-capillaroscopy-in-systemic-lupus-erythematosus-a-systematic-review-and-critical-appraisal
#8
REVIEW
Maurizio Cutolo, Karin Melsens, Sara Wijnant, Francesca Ingegnoli, Kristof Thevissen, Filip De Keyser, Saskia Decuman, Ulf Müller-Ladner, Yves Piette, Valeria Riccieri, Nicola Ughi, Els Vandecasteele, Amber Vanhaecke, Vanessa Smith
Nailfold capillaroscopy is an easy, non-invasive technique to assess microvascular involvement in rheumatic diseases. Multiple studies describe capillaroscopic changes in systemic lupus erythematosus (SLE), including a wide range of non-specific findings. On behalf of the European League Against Rheumatism (EULAR) study group on microcirculation in rheumatic diseases, a systematic review was done to obtain all original research studies (in English) in which SLE patients had capillaroscopy. Forty such studies are identified...
February 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29423720/association-of-interferon-regulatory-factor-5-irf5-gene-polymorphisms-with-juvenile-idiopathic-arthritis
#9
Samira Esmaeili Reykande, Arezou Rezaei, Maryam Sadr, Mahsima Shabani, Farnaz Najmi Varzaneh, Vahid Ziaee, Nima Rezaei
Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play a fundamental role in its pathogenesis. In this study, we aimed to assess the association of IRF5 gene polymorphisms with susceptibility of JIA in Iranian population. Three IRF5 single-nucleotide polymorphisms (rs10954213 A/G, rs2004640 G/T, and rs3807306 G/T) were genotyped using TaqMan assays in 55 patients with JIA and 63 matched healthy individuals...
February 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29421431/introducing-autoimmunity-at-the-synapse-by-a-novel-animal-model-of-experimental-autoimmune-myasthenia-gravis
#10
REVIEW
Jianwen Wang, Yatao Xiao, Kejing Zhang, Benyan Luo, Chengyong Shen
The neuromuscular junction (NMJ) is a peripheral synapse between motor neurons and skeletal muscle fibers that controls muscle contraction. The NMJ is the target of various disorders including myasthenia gravis (MG), an autoimmune disease in which auto-antibodies (auto-Abs) attack the synapse, and thus cause muscle weakness in patients. There are multiple auto-Abs in the MG patient sera, but not all the Abs are proven to be pathogenic, which increases the difficulties in clinical diagnoses and treatments. To establish the causative roles of auto-Abs in MG pathogenesis, the experimental autoimmune MG (EAMG) induced by the active immunization of auto-antigens (auto-Ags) or the passive transfer of auto-Abs is required...
February 5, 2018: Neuroscience
https://www.readbyqxmd.com/read/29421274/autonomous-role-of-wiskott-aldrich-syndrome-platelet-deficiency-in-inducing-autoimmunity-and-inflammation
#11
Lucia Sereni, Maria Carmina Castiello, Francesco Marangoni, Achille Anselmo, Dario di Silvestre, Sara Motta, Elena Draghici, Stefano Mantero, Adrian J Thrasher, Silvia Giliani, Alessandro Aiuti, Pierluigi Mauri, Luigi D Notarangelo, Marita Bosticardo, Anna Villa
BACKGROUND: Wiskott-Aldrich Syndrome (WAS) is an X-linked immunodeficiency characterized by eczema, infections and susceptibility to develop autoimmunity and malignancies. Thrombocytopenia is a constant finding, but its pathogenesis remains elusive. OBJECTIVE: To dissect the basis of WAS platelet (PLT) defect we used a novel conditional mouse model (CoWas) lacking WASp only in the megakaryocytic lineage in presence of a normal immunological environment and in parallel we analysed samples obtained from WAS patients...
February 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29421152/smac-mimetic-induces-an-early-wave-of-gene-expression-via-nf-%C3%AE%C2%BAb-and-ap-1-and-a-second-wave-via-tnfr1-signaling
#12
Nadine Schmidt, Tinka Haydn, Ines Schneider, Hauke Busch, Melanie Boerries, Simone Fulda
Smac (second mitochondria-derived activator of caspases) mimetics are considered as promising cancer therapeutics, but little is yet known about how they alter gene expression. In this study, we used an unbiased genome-wide expression array to investigate gene regulation induced by the Smac mimetic BV6 in breast cancer cell lines. Here, we discover that tumor necrosis factor (TNF)α/TNF receptor 1 (TNFR1) auto-/paracrine signaling regulates Smac mimetic-stimulated changes in gene expression in a time-dependent manner...
February 5, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29414660/increased-circulating-cd4-cxcr5-foxp3-follicular-regulatory-t-cells-correlated-with-severity-of-systemic-lupus-erythematosus-patients
#13
Chen Liu, Dongwei Wang, Ying Song, Songsong Lu, Jingzhong Zhao, Hui Wang
As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR) could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain immune homeostasis. The unbalance of TFR and TFH cells could result in abnormal germinal center responses and contribute to pathogenesis of autoimmune diseases. However, the role of TFR cells in systemic lupus erythematosus (SLE) remains unclear. This study revealed a significant increase of CD4+CXCR5+FOXP3+ TFR cells in peripheral blood of SLE patients compared with healthy controls...
January 30, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29404726/the-enigmatic-neutrophil-what-we-do-not-know
#14
REVIEW
Paul Kubes
The neutrophil appears to be undergoing a renaissance of sorts. While it was for many years thought to be a killing machine brought into tissues to eradicate pathogens, it is now being implicated in many other processes, ranging from acute injury and repair, chronic inflammatory processes, cancer and auto-immunity. Not only is it an effector of the innate immune response, it appears to also potentially contribute to adaptive immunity, implicated in either contributing to the development of specific adaptive immune responses or perhaps even instructing and directing certain adaptive immune responses...
February 5, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29402130/behavioral-and-hematological-responses-of-broiler-chickens-administered-with-betaine-and-ascorbic-acid-during-hot-dry-season
#15
Ifeanyichukwu C Egbuniwe, Joseph O Ayo, Mohammed U Kawu, Aliyu Mohammed
Heat stress is a major problem in poultry production in tropical regions. Assessing the impact of thermally stressful environmental conditions on the welfare of broiler chickens is of great importance. Behavioral responses in a novel environment and hematology of broiler chickens administered with betaine and/or ascorbic acid (AA) during the hot-dry season were evaluated. Broiler chickens were randomly divided into four groups: Group I (control) was given sterile water, Group II was given betaine, Group III was given AA, and Group IV received betaine + AA orally and daily for 42 days...
February 5, 2018: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/29399328/jak-inhibitors-for-the-treatment-of-myeloproliferative-neoplasms-and-other-disorders
#16
REVIEW
William Vainchenker, Emilie Leroy, Laure Gilles, Caroline Marty, Isabelle Plo, Stefan N Constantinescu
JAK inhibitors have been developed following the discovery of the JAK2 V617F in 2005 as the driver mutation of the majority of non- BCR-ABL1 myeloproliferative neoplasms (MPNs). Subsequently, the search for JAK2 inhibitors continued with the discovery that the other driver mutations ( CALR and MPL ) also exhibited persistent JAK2 activation. Several type I ATP-competitive JAK inhibitors with different specificities were assessed in clinical trials and exhibited minimal hematologic toxicity. Interestingly, these JAK inhibitors display potent anti-inflammatory activity...
2018: F1000Research
https://www.readbyqxmd.com/read/29395885/-dermatological-features-of-auto-inflammatory-recurrent-fevers
#17
A Escudier, F-X Mauvais, P Bastard, C Boussard, A Jaoui, V Koskas, E Lecoq, A Michel, M-C Orcel, P-E Truelle, D Wohrer, M Piram
Auto-inflammatory diseases are characterized by unexplained and recurrent attacks of systemic inflammation often involving the skin, joints, or serosal membranes. They are due to a dysfunction or dysregulation of the innate immunity, which is the first line of defense against pathogens. Early recognition of these diseases by the clinician, especially by pediatricians encountering such pathologies in pediatric patients, is primordial to avoid complications. Skin manifestations, common in most auto-inflammatory diseases, are helpful for prompt diagnosis...
January 29, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29394145/the-journey-of-islet-cell-transplantation-and-future-development
#18
Anissa Gamble, Andrew R Pepper, Antonio Bruni, A M James Shapiro
Intraportal islet transplantation has proven to be efficacious in preventing severe hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes. Multiple islet infusions are often required to achieve and maintain insulin independence. Many challenges remain in clinical islet transplantation, including substantial islet cell loss early and late after islet infusion. Contributions to graft loss include the instant blood-mediated inflammatory reaction, potent host auto- and alloimmune responses, and beta cell toxicity from immunosuppressive agents...
February 2, 2018: Islets
https://www.readbyqxmd.com/read/29392770/the-good-the-not-so-bad-and-the-ugly-of-immune-homeostasis-in-melanoma
#19
REVIEW
Jessica da Gama Duarte, Katherine Woods, Miles C Andrews, Andreas Behren
Within the immune system multiple mechanisms balance the need for efficient pathogen recognition and destruction with the prevention of tissue damage by excessive, inappropriate or even self-targeting (auto)immune reactions. This immune homeostasis is a tightly regulated system which fails during tumor development, often due to the hijacking of its essential self-regulatory mechanisms by cancer cells. It is facilitated not only by tumor intrinsic properties, but also by the microbiome, host genetics and other factors...
February 2, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29390318/hymenolepis-nana-a-case-report-of-a-perfect-ibd-camouflage-warrior
#20
Juergen Hench, Gieri Cathomas, Matthias S Dettmer
RATIONALE: There is evidence that parasitic helminths can ameliorate colitis in animal models and humans. Although infections with Hymenolepis sp. are clinically benign, the immunomodulatory interactions between host and parasite are largely unknown. PATIENT CONCERNS: In this study we examined the intestinal mucosa of an adult asymptomatic patient harboring adult and larval dwarf tapeworms (Hymenolepis nana) who underwent surgery for an unrelated reason. INTERVENTIONS: Routine histology and immunohistochemistry were performed to characterize the host's response to the parasite...
December 2017: Medicine (Baltimore)
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