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https://www.readbyqxmd.com/read/29031957/exercise-training-attenuates-experimental-autoimmune-encephalomyelitis-by-peripheral-immunomodulation-rather-than-direct-neuroprotection
#1
Ofira Einstein, Nina Fainstein, Olga Touloumi, Roza Lagoudaki, Ester Hanya, Nikolaos Grigoriadis, Abram Katz, Tamir Ben-Hur
BACKGROUND: Conflicting results exist on the effects of exercise training (ET) on Experimental Autoimmune Encephalomyelitis (EAE), nor is it known how exercise impacts on disease progression. OBJECTIVE: We examined whether ET ameliorates the development of EAE by modulating the systemic immune system or exerting direct neuroprotective effects on the CNS. METHODS: Healthy mice were subjected to 6weeks of motorized treadmill running. The Proteolipid protein (PLP)-induced transfer EAE model in mice was utilized...
October 11, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29030011/influence-of-pasteurella-multocida-toxin-on-the-differentiation-of-dendritic-cells-into-osteoclasts
#2
Sushmita Chakraborty, Bianca Kloos, Nina Roetz, Silke Schmidt, Tatjana Eigenbrod, Shigeki Kamitani, Katharina F Kubatzky
Dendritic cells (DC) are antigen-presenting cells that connect the innate and adaptive immune system to ensure an efficient immune response during the course of an infection. Recently, DC came into the spotlight as a potential source of osteoclast progenitors, especially under (auto)inflammatory conditions. The virulence factor Pasteurella multocida Toxin (PMT) causes atrophic rhinitis in pigs, a disease characterised by a severe reduction of nasal bone. Our group and others have shown the potential of PMT in mediating differentiation of monocytes/macrophages into bone-resorbing osteoclasts...
September 12, 2017: Immunobiology
https://www.readbyqxmd.com/read/29028829/sodium-excretion-is-higher-in-patients-with-rheumatoid-arthritis-than-in-matched-controls
#3
Sarah Marouen, Guilhem du Cailar, Rachel Audo, Cedric Lukas, Gaelle Vial, Anne Tournadre, Emmanuel Barrat, Jean Ribstein, Bernard Combe, Jacques Morel, Claire I Daien
OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion. RESULTS: Sodium excretion was greater for patients with early RA (2,849±1,350 vs...
2017: PloS One
https://www.readbyqxmd.com/read/29020090/saporin-conjugated-tetramers-identify-efficacious-anti-hiv-cd8-t-cell-specificities
#4
Ellen M Leitman, Christine D Palmer, Søren Buus, Fabian Chen, Lynn Riddell, Stuart Sims, Paul Klenerman, Asier Sáez-Cirión, Bruce D Walker, Paul R Hess, Marcus Altfeld, Philippa C Matthews, Philip J R Goulder
Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We here describe a novel application of cytotoxic saporin-conjugated tetramers to kill antigen-specific T-cells without significant off-target effects. The relative efficacy of distinct antiviral CD8+ T-cell specificity can be directly assessed via antigen-specific CD8+ T-cell depletion...
2017: PloS One
https://www.readbyqxmd.com/read/28993766/therapeutic-potential-of-shark-anti-icosl-vnar-domains-is-exemplified-in-a-murine-model-of-autoimmune-non-infectious-uveitis
#5
Marina Kovaleva, Katherine Johnson, John Steven, Caroline J Barelle, Andrew Porter
Induced costimulatory ligand (ICOSL) plays an important role in the activation of T cells through its interaction with the inducible costimulator, ICOS. Suppression of full T cell activation can be achieved by blocking this interaction and has been shown to be an effective means of ameliorating disease in models of autoimmunity and inflammation. In this study, we demonstrated the ability of a novel class of anti-ICOSL antigen-binding single domains derived from sharks (VNARs) to effectively reduce inflammation in a murine model of non-infectious uveitis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28990564/-mirnas-new-actors-in-the-physiopathology-of-multiple-sclerosis
#6
Ferdinand Jagot, Nathalie Davoust
Multiple sclerosis (MS) is an auto-immune demyelinating disorder characterized by a chronic neuro-inflammatory process associated with an infiltration of the central nervous system (CNS) by autoreactive lymphocytes. The etiology of the disease remains unclear but the recent discovery of a dysregulated miRNA network in both cells and extracellular fluids of MS patients has brought new insights on the pathophysiological mechanisms involved in this disorder. miRNAs can induce a T cell polarization towards a pathological Th17 or Th1 phenotype and a deleterious activation of microglia, the CNS-resident macrophages...
June 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28979622/-vitiligo-revealing-vogt-koyanagi-harada-disease
#7
Mohamed El Amraoui, Youssef Zemmez, Ahmed Bouhamidi, Rachid Frikh, Naoufal Hjira, Mohammed Boui
Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28978473/generation-of-ror%C3%AE-t-antigen-specific-t-regulatory-17-cells-from-foxp3-precursors-in-autoimmunity
#8
Byung-Seok Kim, Huiping Lu, Kenji Ichiyama, Xiang Chen, Yi-Bing Zhang, Nipun A Mistry, Kentaro Tanaka, Young-Hee Lee, Roza Nurieva, Li Zhang, Xuexian Yang, Yeonseok Chung, Wei Jin, Seon Hee Chang, Chen Dong
Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt(+) Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORγt(+) Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal RORγt(+) Treg cells in their transcriptomes, peripheral RORγt(+) Treg cells were derived from Foxp3(+) thymic Treg cells in an antigen-specific manner...
October 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28977749/chemical-approaches-to-modulating-complement-mediated-diseases
#9
Abishek Iyer, Weijun Xu, Robert C Reid, David P Fairlie
Numerous diseases are driven by chronic inflammation, placing major burdens on our health systems. Controlling inflammation is an important preventative and therapeutic goal. Over forty 'Complement' proteins are produced in blood or on cell surfaces through activation of the Complement protein network by infection or injury. These proteins complement immune cells and antibodies to identify, tag, destroy and eliminate pathogens and infected or damaged cells, and repair tissues. If the inflammatory stimulus is not removed by localized acute immune responses, Complement activation may be prolonged or misdirected to healthy cells, and chronic inflammation can lead to inflammatory or auto-immune diseases...
October 4, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28974092/poly-i-c-encapsulating-nanoparticles-enhance-innate-immune-responses-to-the-tuberculosis-vaccine-bacille-calmette-gu%C3%A3-rin-bcg-via-synergistic-activation-of-innate-immune-receptors
#10
Martin T Speth, Urska Repnik, Elisabeth Müller, Julia Spanier, Ulrich Kalinke, Alexandre Corthay, Gareth Griffiths
The attenuated live vaccine strain Bacille Calmette-Guérin (BCG) is currently the only available vaccine against tuberculosis (TB), but is largely ineffective against adult pulmonary TB, the most common disease form. This is in part due to BCG's ability to interfere with the host innate immune response, a feature that might be targeted to enhance the potency of this vaccine. Here, we investigated the ability of chitosan-based nanoparticles (pIC-NPs) containing polyinosinic-polycytidylic acid (poly(I:C)), an inducer of innate immunity via Toll-like receptor 3 (TLR3) to enhance the immunogenicity of BCG in mouse bone marrow-derived macrophages (BMDM) in vitro...
October 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28971103/towards-developing-a-vaccine-for-rheumatic-heart-disease
#11
REVIEW
Geethanjali Devadoss Gandhi, Navaneethakrishnan Krishnamoorthy, Ussama M Abdel Motal, Magdi Yacoub
Rheumatic heart disease (RHD) is the most serious manifestations of rheumatic fever, which is caused by group A Streptococcus (GAS or Streptococcus pyogenes) infection. RHD is an auto immune sequelae of GAS pharyngitis, rather than the direct bacterial infection of the heart, which leads to chronic heart valve damage. Although antibiotics like penicillin are effective against GAS infection, improper medical care such as poor patient compliance, overcrowding, poverty, and repeated exposure to GAS, leads to acute rheumatic fever and RHD...
March 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28971075/relationship-between-sleep-pain-and-inflammatory-markers-in-patients-with-rheumatoid-arthritis
#12
Majid Purabdollah, Sima Lakdizaji, Azad Rahmani
Introduction: Rheumatoid Arthritis (RA) is known as a progressive chronic auto-immune disease. Measurement of inflammatory markers are applied for follow up the activity of disease. So determining factors that effects these markers such as sleep and pain can help to prevent the severity of disease. The aim of study was to determine the relationship between sleep disorders, pain and inflammatory markers in patients with RA. Methods: Participants included 210 patients with RA referred to educational medical clinics of Imam Reza and Sina in Tabriz selected by convenience sampling...
September 2017: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28969235/super-refractory-status-epilepticus-a-therapeutic-challenge-in-paediatrics
#13
Shrikiran Aroor, Kanaparthi Shravan, Suneel C Mundkur, C Jayakrishnan, Sai Sripad Rao
A status epilepticus which persists for 24 hours or more after starting treatment with anaesthesia or has recurred inspite of general anaesthesia is known as Super-Refractory Status Epilepticus (SRSE). It includes cases where status epilepticus recurs on reduction or withdrawal of anaesthesia. SRSE, though infrequently seen, constitutes a medical emergency due to the associated high morbidity and mortality. No clear cut guidelines are available till date for the management of SRSE. Most of the published literature was case reports and expert opinion...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28969181/a-rare-cause-of-anaemia-in-hiv-aids
#14
Samarth Virmani, Rama Bhat, Raghavendra Rao, Ruchee Khanna, Lipisha Agarwal
Patients living with HIV are commonly diagnosed with anaemia which can have various aetiologies. However, one of the rare causes of anaemia in such patients is Auto Immune Haemolytic Anaemia (AIHA), which is difficult to diagnose due to the absence of reticulocytosis in HIV patients. Such patients can be treated with corticosteroids which can gradually be tapered off over a period of time. The following is a case of a 52-year-old male living with HIV who was diagnosed to have AIHA and was successfully treated with steroids...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28961019/damage-associated-molecular-patterns-and-their-role-as-initiators-of-inflammatory-and-auto-immune-signals-in-systemic-lupus-erythematosus
#15
Karen Álvarez, Gloria Vasquez
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released into the extracellular space under conditions of activation, cellular stress, or tissue damage. These molecules are recognized by pattern-recognition receptors (PRRs) and can induce inflammation and immune responses in the absence of infection. An increasing number of DAMPs have been linked to the pathogenesis of many auto-immune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriatic arthritis, and systemic sclerosis (SSc); as they promote the maturation/activation of different immune cells and pro-inflammatory cytokines production associated with these diseases...
September 29, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28960510/expression-of-cd-markers-in-immune-thrombocytopenic-purpura-prognostic-approaches
#16
REVIEW
Masumeh Maleki Behzad, Ali Amin Asnafi, Kaveh Jaseb, Mohammad Ali Jalali Far, Najmaldin Saki
Immune Thrombocytopenic Purpura (ITP) is a common autoimmune bleeding disorder characterized by a reduction in peripheral blood platelet counts. In this disease, autoantibodies (Auto-Abs) are produced against platelet GPIIb/GPIIIa by B cells, which require interaction with T cells. In this review, the importance of B and T lymphocytes in ITP prognosis has been studied. Relevant literature was identified by a PubMed search (1990-2016) of English-language papers using the terms B and T lymphocyte, platelet, CD markers and immune thrombocytopenic purpura...
September 28, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28959348/in-silico-perspectives-on-the-prediction-of-the-plp-s-epitopes-involved-in-multiple-sclerosis
#17
Zahra Zamanzadeh, Mitra Ataei, Seyed Massood Nabavi, Ghasem Ahangari, Mehdi Sadeghi, Mohammad Hosein Sanati
BACKGROUND: Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS). The main cause of the MS is yet to be revealed, but the most probable theory is based on the molecular mimicry that concludes some infections in the activation of T cells against brain auto-antigens that initiate the disease cascade. OBJECTIVES: The Purpose of this research is the prediction of the auto-antigen potency of the myelin proteolipid protein (PLP) in multiple sclerosis...
March 2017: Iranian journal of biotechnology
https://www.readbyqxmd.com/read/28952230/how-can-we-effectively-address-the-paraneoplastic-dermatomyositis-diagnosis-risk-factors-and-treatment-options
#18
Ioannis Zerdes, Maria Tolia, Michail Nikolaou, Nikolaos Tsoukalas, Louloudenia Velentza, Jiannis Hajiioannou, Michail Mitsis, George Kyrgias
PURPOSE: Dermatomyositis (DM) represents an auto-immune inflammatory myopathy. In this review, we analyzed the incidence of DM as a clinical manifestation highlighting the peculiar clinical and treatment characteristics of this disease when occurring in the context of different malignancies. METHODS: A systematic literature review was performed based on database search in PubMed/Medline and included English articles until December 2016. RESULTS: In up to 20% of cases DM appears as a paraneoplastic syndrome associated with multiple malignancies such as ovarian, breast, prostate, lung, nasopharyngeal and colorectal cancer, and non-Hodgkin lymphomas...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28950945/adhesion-gpcrs-in-regulating-immune-responses-and-inflammation
#19
Hsi-Hsien Lin, Cheng-Chih Hsiao, Caroline Pabst, Josée Hébert, Torsten Schöneberg, Jörg Hamann
The adhesion family comprises one of the five major clades of G protein-coupled receptors (GPCRs). Unlike conventional GPCRs, adhesion GPCRs (aGPCRs) have extended ectodomains with various protein folds that facilitate protein-protein interactions and, hence, putative cellular adhesive functions. Juxtaposed to the seven-pass transmembrane domain is a GPCR autoproteolysis-inducing domain that enables autoproteolytic cleavage of the receptor, resulting in a bipartite structure of many aGPCRs. aGPCRs are widely distributed and play critical roles in many developmental processes; yet, the underlying mechanisms of activation and signal transduction have emerged only recently...
2017: Advances in Immunology
https://www.readbyqxmd.com/read/28950389/design-and-evaluation-of-chronomodulated-drug-delivery-of-tramadol-hydrochloride
#20
Thota Alekya, Dudhipala Narendar, Donthi Mahipal, Narala Arjun, Banala Nagaraj
Rheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH dependent polymer of Eudragit S100...
September 26, 2017: Drug Research
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