keyword
https://read.qxmd.com/read/38497754/transformer-based-spatial-temporal-detection-of-apoptotic-cell-death-in-live-cell-imaging
#1
JOURNAL ARTICLE
Alain Pulfer, Diego Ulisse Pizzagalli, Paolo Armando Gagliardi, Lucien Hinderling, Paul Lopez, Romaniya Zayats, Pau Carrillo-Barberà, Paola Antonello, Miguel Palomino-Segura, Benjamin Grädel, Mariaclaudia Nicolai, Alessandro Giusti, Marcus Thelen, Luca Maria Gambardella, Thomas T Murooka, Olivier Pertz, Rolf Krause, Santiago Fernandez Gonzalez
Intravital microscopy has revolutionized live-cell imaging by allowing the study of spatial-temporal cell dynamics in living animals. However, the complexity of the data generated by this technology has limited the development of effective computational tools to identify and quantify cell processes. Amongst them, apoptosis is a crucial form of regulated cell death involved in tissue homeostasis and host defense. Live-cell imaging enabled the study of apoptosis at the cellular level, enhancing our understanding of its spatial-temporal regulation...
March 18, 2024: ELife
https://read.qxmd.com/read/38497405/nanoplatform-based-strategies-for-enhancing-the-lethality-of-current-antitumor-pdt
#2
REVIEW
Xin-Xin Lu, Chun Xue, Jian-Hui Dong, Yi-Zhou Zhang, Fan Gao
Photodynamic therapy (PDT) exhibits great application prospects in future clinical oncology due to its spatiotemporal controllability and good biosafety. However, the antitumor efficacy of PDT is seriously hindered by many factors, including tumor hypoxia, limited light penetration ability, and strong defense mechanisms of tumors. Considering that it is difficult to completely solve the first two problems, enhancing the lethality of antitumor PDT has become a good idea to extend its clinical application. Herein, we summarize the nanoplatform-involved strategies to effectively amplify the tumoricidal capability of current PDT and then discuss the present bottlenecks and prospects of the nanoplatform-based PDT sensitization strategies in tumor therapy...
March 18, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38496311/cecropin-a-investigation-of-a-host-defense-peptide-with-multifaceted-immunomodulatory-activity-in-a-chicken-hepatic-cell-culture
#3
JOURNAL ARTICLE
Rege Anna Márton, Csilla Sebők, Máté Mackei, Patrik Tráj, Júlia Vörösházi, Ágnes Kemény, Zsuzsanna Neogrády, Gábor Mátis
INTRODUCTION: Host defense peptides (HDPs) are increasingly referred to as promising candidates for the reduction of the use of conventional antibiotics, thereby combating antibiotic resistance. As HDPs have been described to exert various immunomodulatory effects, cecropin A (CecA) appears to be a potent agent to influence the host inflammatory response. METHODS: In the present study, a chicken primary hepatocyte-non-parenchymal cell co-culture was used to investigate the putative immunomodulatory effects of CecA alone and in inflammatory conditions evoked by polyinosinic-polycytidylic acid (Poly I:C)...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38494930/eacvp-an-esm-2-lm-framework-combined-cnn-and-cbam-attention-to-predict-anti-coronavirus-peptides
#4
JOURNAL ARTICLE
Shengli Zhang, Yuanyuan Jing, Yunyun Liang
BACKGROUND: The novel coronavirus pneumonia (COVID-19) outbreak in late 2019 killed millions worldwide. Coronaviruses cause diseases such as severe acute respiratory syndrome (SARS-Cov) and SARS-COV-2. Many peptides in the host defense system have antiviral activity. How to establish a set of efficient models to identify anti-coronavirus peptides is a meaningful study. METHODS: Given this, a new prediction model EACVP is proposed. This model uses the evolutionary scale language model (ESM-2 LM) to characterize peptide sequence information...
March 15, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38494143/tigar-reduces-neuronal-ferroptosis-by-inhibiting-succinate-dehydrogenase-activity-in-cerebral-ischemia
#5
JOURNAL ARTICLE
Xinxin Wang, Mei Li, Fan Wang, Guanghui Mao, Junchao Wu, Rong Han, Rui Sheng, Zhenghong Qin, Hong Ni
Ischemia Stroke (IS) is an acute neurological condition with high morbidity, disability, and mortality due to a severe reduction in local cerebral blood flow to the brain and blockage of oxygen and glucose supply. Oxidative stress induced by IS predisposes neurons to ferroptosis. TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits the intracellular glycolytic pathway to increase pentose phosphate pathway (PPP) flux, promotes NADPH production and thus generates reduced glutathione (GSH) to scavenge reactive oxygen species (ROS), and thus shows strong antioxidant effects to ameliorate cerebral ischemia/reperfusion injury...
March 15, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38493337/protecting-the-last-line-of-defense-analytical-approaches-for-sample-preparation-and-determination-of-the-reserve-group-of-antibiotics-in-the-environment
#6
REVIEW
Joanna Wilk, Sylwia Bajkacz
Drug resistance in microorganisms is a serious threat to life and health due to the limited number of antibiotics that show efficacy in treating infections and the difficulty in discovering new compounds with antibacterial activity. To address this issue, the World Health Organization created the AWaRe classification, a tool to support global and national antimicrobial stewardship programs. The AWaRe list categorizes antimicrobials into three groups - Access, Watch, and Reserve - according to their intended use...
March 17, 2024: Critical Reviews in Analytical Chemistry
https://read.qxmd.com/read/38488001/zmynd8-protects-breast-cancer-stem-cells-against-oxidative-stress-and-ferroptosis-through-activation-of-nrf2
#7
JOURNAL ARTICLE
Maowu Luo, Lei Bao, Yuanyuan Xue, Ming Zhu, Ashwani Kumar, Chao Xing, Jennifer E Wang, Yingfei Wang, Weibo Luo
Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrogenase-high (ALDHhi) BCSCs, leading to BCSC expansion and tumor initiation in mice. The underlying mechanism involved a two-fold posttranslational regulation of nuclear factor erythroid 2-related factor 2 (NRF2)...
January 23, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38483964/characterization-of-intestinal-o-glycome-in-reactive-oxygen-species-deficiency
#8
JOURNAL ARTICLE
Radka Saldova, Kristina A Thomsson, Hayden Wilkinson, Maitrayee Chatterjee, Ashish K Singh, Niclas G Karlsson, Ulla G Knaus
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation resulting from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Reactive oxygen species (ROS) generated by NADPH oxidases (NOX) provide antimicrobial defense, redox signaling and gut barrier maintenance. NADPH oxidase mutations have been identified in IBD patients, and mucus layer disruption, a critical aspect in IBD pathogenesis, was connected to NOX inactivation. To gain insight into ROS-dependent modification of epithelial glycosylation the colonic and ileal mucin O-glycome of mice with genetic NOX inactivation (Cyba mutant) was analyzed...
2024: PloS One
https://read.qxmd.com/read/38483863/therapeutic-potential-of-salidroside-in-preserving-rat-cochlea-organ-of-corti-from-gentamicin-induced-injury-through-modulation-of-nrf2-signaling-and-gsk3%C3%AE-nf-%C3%AE%C2%BAb-pathway
#9
JOURNAL ARTICLE
Yan Zhang, Shuyuan Yu, Xinyi Guo, Luoying Wang, Ling Yu, Ping Wang
Salidroside (SAL) is a phenol glycoside compound found in plants of the Rhodiola genus which has natural antioxidant and free radical scavenging properties. SAL are able to protect against manganese-induced ototoxicity. However, the molecular mechanism by which SAL reduces levels of reactive oxygen species (ROS) is unclear. Here, we established an in vitro gentamicin (GM) ototoxicity model to observe the protective effect of SAL on GM-induced hair cells (HC) damage. Cochlear explants of postnatal day 4 rats were obtained and randomly divided into six groups: two model groups (treatment with 0...
2024: PloS One
https://read.qxmd.com/read/38480500/eugenol-possesses-colitis-protective-effects-impacts-on-the-tlr4-myd88-nf-formula-see-text-b-pathway-intestinal-epithelial-barrier-and-macrophage-polarization
#10
JOURNAL ARTICLE
Jun-Jie Huang, Yue-Min Feng, Shu-Mei Zheng, Cheng-Long Yu, Rui-Gang Zhou, Ming-Jiang Liu, Ruo-Nan Bo, Jie Yu, Jin-Gui Li
Eugenol (EU) has been shown to ameliorate experimental colitis due to its anti-oxidant and anti-inflammatory bioactivities. In this study, DSS-induced acute colitis was established and applied to clarify the regulation efficacy of EU on intestinal barrier impairment and macrophage polarization imbalance along with the inflammatory response. Besides, the adjusting effect of EU on macrophages was further investigated in vitro. The results confirmed that EU intervention alleviated DSS-induced colitis through methods such as restraining weight loss and colonic shortening and decreasing DAI scores...
March 14, 2024: American Journal of Chinese Medicine
https://read.qxmd.com/read/38479233/microbial-regulation-of-plant-secondary-metabolites-impact-mechanisms-and-prospects
#11
REVIEW
Jiayan Lv, Shuangyu Yang, Wei Zhou, Zhongwang Liu, Jinfang Tan, Mi Wei
Plant secondary metabolites possess a wide range of pharmacological activities and play crucial biological roles. They serve as both a defense response during pathogen attack and a valuable drug resource. The role of microorganisms in the regulation of plant secondary metabolism has been widely recognized. The addition of specific microorganisms can increase the synthesis of secondary metabolites, and their beneficial effects depend on environmental factors and plant-related microorganisms. This article summarizes the impact and regulatory mechanisms of different microorganisms on the main secondary metabolic products of plants...
March 8, 2024: Microbiological Research
https://read.qxmd.com/read/38478518/cytokinin-oxidase-gene-ckx5-is-modulated-in-the-immunity-of-arabidopsis-to-botrytis-cinerea
#12
JOURNAL ARTICLE
Ruolin Wang, Beibei Li, Jiang Zhang, Ling Chang
In our previous work, cytokinin (CK) signaling and biosynthesis were found to be modulated during Arabidopsis defense against infection by the necrotrophic pathogen Botrytis cinerea. Notably, the expression level of CYTOKININ OXIDASE/DEHYDROGENASE 5 (CKX5) was significantly induced in B. cinerea-infected leaves and later in distant B. cinerea-untreated leaves of the same plant. To confirm and determine how CKX5 is involved in the response to B. cinerea infection, transcript levels of CKX family genes were analyzed in B...
2024: PloS One
https://read.qxmd.com/read/38477873/xiaoyu-hu-let-the-data-guide-you
#13
JOURNAL ARTICLE
Lucie Van Emmenis
Xiaoyu Hu is a professor and director of the Institute for Immunology at Tsinghua University. Her lab is interested in understanding the molecular mechanisms underlying the transcriptional, translational, and metabolic mechanisms of the key cell types involved in host defense and inflammatory responses: macrophages and intestinal epithelial cells (IECs). We recently spoke with Xiaoyu about her current work, the benefits of a multidisciplinary team, and how being part of journal editorial boards brings her intellectual stimulation and inspiration for her own lab...
April 1, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38475578/evaluation-of-virus-free-chrysanthemum-hangju-productivity-and-response-to-virus-reinfection-in-the-field-molecular-insights-into-virus-host-interactions
#14
JOURNAL ARTICLE
Xuejie Du, Xinqiao Zhan, Xueting Gu, Xinyi Liu, Bizeng Mao
The shoot apical meristem culture has been used widely to produce virus-free plantlets which have the advantages of strong disease resistance, high yield, and prosperous growth potential. However, this virus-free plant will be naturally reinfected in the field. The physiological and metabolic responses in the reinfected plant are still unknown. The flower of chrysanthemum 'Hangju' is a traditional medicine which is unique to China. In this study, we found that the virus-free 'Hangju' (VFH) was reinfected with chrysanthemum virus B/R in the field...
March 5, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38470902/an-nlp-based-novel-approach-for-assessing-national-influence-in-clause-dissemination-across-bilateral-investment-treaties
#15
JOURNAL ARTICLE
Shahadat Uddin, Haohui Lu, Wolfgang Alschner, Dori Patay, Nicholas Frank, Fabio S Gomes, Anne Marie Thow
International investment agreements (IIAs) promote foreign investment. However, they can undermine crucial health programs, creating a dilemma for governments between corporate and public health interests. For this reason, including clauses that safeguard health has become an essential practice in IIAs. According to the current literature, some countries have played a pivotal role in leading this inclusion, while others follow the former ones. However, the existing literature needs a unique approach that can quantify the influence strength of a country in disseminating clauses that explicitly mention health provisions to others...
2024: PloS One
https://read.qxmd.com/read/38470484/differential-effects-of-winter-cold-stress-on-soil-bacterial-communities-metabolites-and-physicochemical-properties-in-two-varieties-of-tetrastigma-hemsleyanum-diels-gilg-in-reclaimed-land
#16
JOURNAL ARTICLE
Xuqing Li, Xiaoxu Ren, Yao Su, Xiang Zhou, Yu Wang, Songlin Ruan, Jianli Yan, Bin Li, Kai Guo
Tetrastigma hemsleyanum Diels & Gilg (TDG) has been recently planted in reclaimed lands in Zhejiang Province, China, to increase reclaimed land use. Winter cold stress seriously limits the growth and development of TDG and has become the bottleneck limiting the TDG planting industry. To investigate the defense mechanisms of TDG toward winter cold stress when grown on reclaimed land, a combined analysis of soil bacterial communities, metabolites, and physicochemical properties was conducted in this study...
March 12, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38467975/endosomal-toll-like-receptors-as-therapeutic-targets-for-autoimmune-diseases
#17
JOURNAL ARTICLE
Kensuke Miyake, Takuma Shibata, Ryutaro Fukui, Yusuke Murakami, Ryota Sato, Ryosuke Hiranuma
Nucleic acid (NA)-sensing Toll-like receptors (TLRs) reside in the endosomal compartment of innate immune cells, such as macrophages and dendritic cells. NAs transported to the endosomal compartment are degraded by DNases and RNases. Degradation products, including single-stranded DNA, oligoRNA, and nucleosides, are recognized by TLR7, TLR8, and TLR9 to drive the defense responses against pathogens. NA degradation influences endosomal TLR responses by generating and degrading TLR ligands. TLR ligand accumulation because of impaired NA degradation causes constitutive TLR activation, leading to autoinflammatory and autoimmune diseases...
2024: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/38466325/imidacloprid-disrupts-larval-molting-regulation-and-nutrient-energy-metabolism-causing-developmental-delay-in-honey-bee-apis-mellifera
#18
JOURNAL ARTICLE
Zhi Li, Yuedi Wang, Qiqian Qin, Lanchun Chen, Xiaoqun Dang, Zhengang Ma, Zeyang Zhou
Imidacloprid is a global health threat that severely poisons the economically and ecologically important honeybee pollinator, Apis mellifera . However, its effects on developing bee larvae remain largely unexplored. Our pilot study showed that imidacloprid causes developmental delay in bee larvae, but the underlying toxicological mechanisms remain incompletely understood. In this study, we exposed bee larvae to imidacloprid at environmentally relevant concentrations of 0.7, 1.2, 3.1, and 377 ppb. There was a marked dose-dependent delay in larval development, characterized by reductions in body mass, width, and growth index...
March 11, 2024: ELife
https://read.qxmd.com/read/38464747/identification-and-transcriptomic-profiling-of-salinity-stress-response-genes-in-colored-wheat-mutant
#19
JOURNAL ARTICLE
Min Jeong Hong, Chan Seop Ko, Jin-Baek Kim, Dae Yeon Kim
BACKGROUND: Salinity is a major abiotic stress that prevents normal plant growth and development, ultimately reducing crop productivity. This study investigated the effects of salinity stress on two wheat lines: PL1 (wild type) and PL6 (mutant line generated through gamma irradiation of PL1). RESULTS: The salinity treatment was carried out with a solution consisting of a total volume of 200 mL containing 150 mM NaCl. Salinity stress negatively impacted germination and plant growth in both lines, but PL6 exhibited higher tolerance...
2024: PeerJ
https://read.qxmd.com/read/38462971/natural-compounds-for-oxidative-stress-and-neuroprotection-in-schizophrenia-composition-mechanisms-and-therapeutic-potential
#20
REVIEW
Anam N Khan, Rahul D Jawarkar, Magdi E A Zaki, Aamal A Al Mutairi
OBJECTIVE: An imbalance between the generation of reactive oxygen species (ROS) and the body's antioxidant defense mechanisms is believed to be a critical factor in the development of schizophrenia (SCZ) like neurological illnesses. Understanding the roles of ROS in the development of SCZ and the potential activity of natural antioxidants against SCZ could lead to more effective therapeutic options for the prevention and treatment of the illness. METHODS: SCZ is a mental disorder characterised by progressive impairments in working memory, attention, and executive functioning...
March 11, 2024: Nutritional Neuroscience
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