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https://www.readbyqxmd.com/read/29454974/proof-of-patient-information-analysis-of-201-judicial-decisions
#1
E Dugleux, H Rached, C Rouge-Maillart
INTRODUCTION: The ruling by the French Court of Cassation dated February 25, 1997 obliged doctors to provide proof of the information given to patients, reversing more than half a century of case law. In October 1997, it was specified that such evidence could be provided by "all means", including presumption. No hierarchy in respect of means of proof has been defined by case law or legislation. The present study analyzed judicial decisions with a view to determining the means of proof liable to carry the most weight in a suit for failure to provide due patient information...
February 15, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29453255/endophyte-mediated-modulation-of-defense-responsive-genes-and-systemic-resistance-in-withania-somnifera-l-dunal-under-alternaria-alternata-stress
#2
Aradhana Mishra, Satyendra Pratap Singh, Sahil Mahfooz, Surendra Pratap Singh, Arpita Bhattacharya, Nishtha Mishra, C S Nautiyal
Endophytes have been explored to perform an important role in plant health. However, their effects on the host physiological function and disease management remains elusive. The present study was aimed to assess the potential of endophytes singly as well as in combination on various physiological parameters and systemic defense mechanism against Alternaria alternata in Withania somnifera (L.) Dunal. Seed priming with endophytic Bacillus amyloliquefaciens and Pseudomonas fluorescens individually and in combination demonstrated enhanced vigor index and germination rate...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29451507/-appropriateness-in-cardiology-a-statement-of-the-anmco-veneto-region
#3
Guerrino Zuin, Gianfranco Frigo, Loris Roncon, Aldo Bonso, Emanuele Carbonieri, Fabio Chirillo, Fabio De Conti, Pietro Delise, Alessandro Desideri, Daniele D'Este, Loredano Milani, Roberto Valle, Claudio Bilato
Inappropriate tests are responsible for longer waiting lists, higher economical costs for the National Health System and major clinical risks due to radiation exposure from prescription abuse of diagnostic testing. Clinical inappropriateness frequently derives from poor knowledge of guidelines, "defensive medicine" approach and/or repeat requests of patients and family members. About one third of non-invasive imaging tests are considered inappropriate.In order to define the most appropriate instruments for the follow-up of the most common cardiovascular diseases with the highest risk of inappropriateness, all the cardiologists of the Veneto Region (Italy), along with the local chapters of the main national cardiology societies and general practitioners have been involved by the Regional Section of the Italian Association of Hospital Cardiologists (ANMCO) in several scientific meetings on the following topics: hypertension, chronic ischemic heart disease, valvular heart disease, heart failure, and atrial fibrillation...
January 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29447398/secular-trends-in-the-physical-fitness-of-united-states-army-infantry-units-and-infantry-soldiers-1976-2015
#4
Joseph J Knapik, Jan E Redmond, Tyson L Grier, Marilyn A Sharp
Introduction: The purpose of this investigation was to examine changes over time in the physical fitness of the United States (US) Army infantry. A systematic review was conducted to identify and analyze articles and databases that reported on physical characteristics (height, weight, and body mass index) and/or Army Physical Fitness Test (APFT) scores of male infantrymen or men in infantry units. Materials and Methods: The National Library of Medicine's PubMed and the Defense Technical Information Center were searched using specific keywords...
February 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29444867/evolutionary-stability-of-antibiotic-protection-in-a-defensive-symbiosis
#5
Tobias Engl, Johannes Kroiss, Marco Kai, Taras Y Nechitaylo, Aleš Svatoš, Martin Kaltenpoth
The increasing resistance of human pathogens severely limits the efficacy of antibiotics in medicine, yet many animals, including solitary beewolf wasps, successfully engage in defensive alliances with antibiotic-producing bacteria for millions of years. Here, we report on the in situ production of 49 derivatives belonging to three antibiotic compound classes (45 piericidin derivatives, 3 streptochlorin derivatives, and nigericin) by the symbionts of 25 beewolf host species and subspecies, spanning 68 million years of evolution...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29439264/innate-immunity-of-the-lung-from-basic-mechanisms-to-translational-medicine
#6
Dominik Hartl, Rabindra Tirouvanziam, Julie Laval, Catherine M Greene, David Habiel, Lokesh Sharma, Ali Önder Yildirim, Charles S Dela Cruz, Cory M Hogaboam
The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment...
February 13, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29435938/transgene-like-animal-models-using-intronic-micrornas
#7
Shi-Lung Lin, Shin-Ju E Chang, Shao-Yao Ying
Transgenic animal models are valuable tools for testing gene functions and drug mechanisms in vivo. They are also the best similitude for a human body for etiological and pathological research of diseases. All pharmaceutically developed medicines must be proven to be safe and effective in animals before approval by the Food and Drug Administration (FDA) to be used in clinical trials. To this end, the transgenic animal models of diseases serve as the front line of drug evaluation. However, there is currently no transgenic animal model for microRNA (miRNA)-related research...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29431139/the-attitudes-towards-defensive-medicine-among-physicians-of-obstetrics-and-gynaecology-in-china-a-questionnaire-survey-in-a-national-congress
#8
Lan Zhu, Lei Li, Jinghe Lang
OBJECTIVE: The study aimed to determine prevalence, patterns and risk factors of defensive medicine by obstetricians and gynaecologists across China. DESIGN: This is a questionnaire survey by written and on-line interview for participants. PARTICIPANTS: Among 1804 registered physicians participating at the 2017 Congress of Chinese Obstetricians and Gynecologists Association in Chengdu City, Sichuan Province, China, from 17 to 20 August 2017, 1486 participants (82...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29425644/ligustilide-attenuates-vascular-inflammation-and-activates-nrf2-ho-1-induction-and-no-synthesis-in-huvecs
#9
Eun Sik Choi, Jung Joo Yoon, Byung Hyuk Han, Da Hye Jeong, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee
BACKGROUND: Ligustilide is a bioactive phthalide derivative isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root) which are both medicinal herbs used to treat circulatory disorders. Vascular endothelium is a central spot in developing cardiovascular diseases and chronic vascular inflammation might result in atherosclerosis development. PURPOSE: We previously found out that a traditional herbal formula, Samul-Tang (Si-Wu-Tang, containing Cnidii Rhizoma and Angelicae Gigantis Radix), attenuated vascular inflammation in human umbilical vein endothelial cells (HUVECs)...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29415032/mechanical-and-phytochemical-protection-mechanisms-of-calligonum-comosum-in-arid-deserts
#10
Sameh Soliman, Mohammad G Mohammad, Ali A El-Keblawy, Hany Omar, Mohamed Abouleish, Mohamed Madkour, Attiat Elnaggar, Racha M Hosni
Unlike animals, plants are sessile organisms, lacking circulating antibodies and specialized immune cells and are exposed to various harsh environmental conditions that make them at risk of being attacked by different pathogens and herbivores. Plants produce chemo-signals to respond to the surroundings and be able to distinguish between harmless and harmful signals. In this study, the production of phytochemicals as plant signaling mechanisms and their defensive roles in disease resistance and repelling herbivores are examined in Calligonum comosum...
2018: PloS One
https://www.readbyqxmd.com/read/29414657/mechanisms-of-action-involved-in-ozone-therapy-in-skin-diseases
#11
REVIEW
Jinrong Zeng, Jianyun Lu
Ozone-therapy initially applied in medicine by an empirical approach, has now reached a new stage where most of the biological mechanisms of ozone action have been clarified, that refers to antimicrobial effects, immunoregulation, antioxidant defenses and epigenetic modification. Current ozone medical preparation in dermatology mainly classified as ozone hydrotherapy, ozonated oil externally used and ozone autohemotherapy (OAHT). Admittedly, ozone is widely used in various fields against gram-negative and gram-positive bacteria, viruses, and fungi...
January 29, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29410385/functional-magnetic-resonance-imaging-evaluation-of-auricular-percutaneous-electrical-neural-field-stimulation-for-fibromyalgia-protocol-for-a-feasibility-study
#12
Melat Gebre, Anna Woodbury, Vitaly Napadow, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Roman Sniecinski, Bruce Crosson
BACKGROUND: Fibromyalgia is a chronic pain state that includes widespread musculoskeletal pain, fatigue, psychiatric symptoms, cognitive and sleep disturbances, and multiple somatic symptoms. Current therapies are often insufficient or come with significant risks, and while there is an increasing demand for non-pharmacologic and especially non-opioid pain management such as that offered through complementary and alternative medicine therapies, there is currently insufficient evidence to recommend these therapies...
February 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29405180/-on-the-occasion-of-the-200th-birthday-anniversary-of-d-e-min
#13
Yu I Pigolkin
This article is dedicated to the memory of the outstanding Russian forensic doctor and literary figure professor D.E. Min on the occasion of his 200th birthday anniversary. The assignment of D.E. Min to the position of the head of Department of the State Medical Practice at the Emperor's Moscow University coincided with the large-scale judiciary reform carried out in the country at that time which envisaged, among other innovations, the practice of questioning of an expert in the court room. The new developments in the practical expert activities required the revision of the former approaches to the education and training of forensic medical experts...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29397088/management-of-acute-cough-by-zataria-multiflora-boiss-as-an-alternative-treatment
#14
REVIEW
Mohaddese Mahboubi
Cough, as a defensive reflux mechanism, removes foreign objects and secretions from bronchi and bronchioles of airways. Zataria multiflora is a popular plant for treatment of cough in Iranian traditional medicine. The aim of this review was to evaluate the potency of Z. multiflora as an alternative treatment in management of acute cough and its possible mechanisms of action. Here the authors compiled information about Z. multiflora in the treatment of cough from all accessible resources and books. The results of this investigation showed that there were five clinical studies that evaluated the efficacy of Z...
January 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29394523/leaf-blade-structure-of-verbesina-macrophylla-cass-f-s-blake-asteraceae-ontogeny-duct-secretion-mechanism-and-essential-oil-composition
#15
Laís de Almeida Bezerra, Pedro Antonio Oliveira Mangabeira, Rosilene Aparecida de Oliveira, Larissa Corrêa do Bomfim Costa, Maura Da Cunha
BACKGROUND: Secretory structures are common in Asteraceae, where they exhibit a high degree of morphological diversity. The species Verbesina macrophylla, popularly known as assa-peixe, is native to Brazil where it is widely used for medicinal purposes. Despite its potential medical importance there have been no studies of the anatomy of this species, especially regarding its secretory structures, or of its secreted compounds. This study aimed to study the anatomy of leaves of V. macrophylla with an emphasis on its secretory structures and secreted secondary metabolites...
February 2, 2018: Plant Biology
https://www.readbyqxmd.com/read/29381864/stress-responses-of-aquatic-plants-to-silver-nanoparticles
#16
Lin Yuan, Curtis Richardson, Mengchi Ho, C Wesley Willis, Benjamin P Colman, Mark R Wiesner
Silver nanoparticles (AgNPs) are increasingly used in consumer products, biotechnology and medicine, and are released into aquatic ecosystems through wastewater discharge. This study investigated the phytotoxicity of AgNPs to aquatic plants, Egeria densa and Juncus effusus by measuring physiologic and enzymatic responses to AgNP exposure under three release scenarios: two chronic (8.7 mg, weekly) exposures to either zero-valent AgNPs or sulfidized silver nanoparticles; and a pulsed (450 mg, one-time) exposure to zero-valent AgNPs...
January 30, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29380708/technology-of-rna-interference-in-advanced-medicine
#17
Fatemeh Abedini, Mohammad Ebrahimi, Hossein Hosseinkhani
RNA interference (RNAi) and related pathways involving small interfering RNAs (siRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs) regulate processes such as anti-viral defense, genome surveillance, heterochromatin formation, and gene expression in animals, plants, and fungi. Studies on RNAi have revealed a two-step mechanism: (i) Degradation of dsRNA into small interfering RNAs (siRNAs), 21 to 25 nucleotides long, by an RNase III-like activity. (ii) The siRNAs join an RNase complex, RISC (RNA-induced silencing complex), which acts on the mRNA and degrades it...
January 29, 2018: MicroRNA
https://www.readbyqxmd.com/read/29360768/pharmacokinetic-study-of-bioactive-flavonoids-in-the-traditional-japanese-medicine-keigairengyoto-exerting-antibacterial-effects-against-staphylococcus-aureus
#18
Takashi Matsumoto, Atsushi Kaneko, Junichi Koseki, Yosuke Matsubara, Setsuya Aiba, Kenshi Yamasaki
Recent studies have demonstrated that flavonoid glucuronides can be deconjugated to the active form aglycone by β-glucuronidase-expressing macrophages. Keigairengyoto (KRT) is a flavonoid-rich traditional Japanese medicine reported to enhance bacterial clearance through immune modulation. Our aims are to examine the pharmacokinetics of KRT flavonoids and to identify active flavonoids contributing to the adjuvant effects of KRT. KRT was evaluated at pharmacokinetic analysis to quantify absorbed flavonoids, and cutaneous infection assay induced in mice by inoculation of Staphylococcus aureus...
January 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29353203/the-water-extract-of-tutsan-hypericum-androsaemum-l-red-berries-exerts-antidepressive-like-effects-and-in-vivo-antioxidant-activity-in-a-mouse-model-of-post-stroke-depression
#19
Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Antoni Sureda, Giovanni Caprioli, Romilde Iannarelli, Arold Jorel Tsetegho Sokeng, Nady Braidy, Sedigheh Khanjani, Akbar Hajizadeh Moghaddam, Atanas G Atanasov, Maria Daglia, Filippo Maggi
Hypericum androsaemum L., commonly known as 'tutsan' or 'shrubby St. John's Wort', is a member of the Hypericum genus found growing spontaneously in the Mediterranean area and is cultivated extensively as an ornamental plant due to the showy color variation in its fresh berry-like capsules, which turn from red to shiny black as they ripen. Tutsan has also been used in Portuguese and Spanish folk medicine to treat depression. In this study, we assessed the beneficial role of the water extract of H. androsaemum red berries (WE) in an experimental animal model of post-stroke depression...
January 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29344683/the-root-transcriptome-of-achyranthes-bidentata-and-the-identification-of-the-genes-involved-in-the-replanting-benefit
#20
Yan Hui Yang, Ming Jie Li, Yan Jie Yi, Rui Fang Li, Cheng Dong, Zhong Yi Zhang
The transcriptome profiling in replanting roots revealed that expression pattern changes of key genes promoted important metabolism pathways, antioxidant and pathogen defense systems, adjusted phytohormone signaling and inhibited lignin biosynthesis. The yield of the medicinal plant Achyranthes bidentata could be significantly increased when replanted into a field cultivated previously for the same crop, but the biological basis of this so-called "replanting benefit" is unknown. Here, the RNA-seq technique was used to identify candidate genes responsible for the benefit...
January 17, 2018: Plant Cell Reports
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