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https://www.readbyqxmd.com/read/29666617/perspectives-of-phage-eukaryotic-cell-interactions-to-control-epstein-barr-virus-infections
#1
Andrzej Górski, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Natalia Bagińska, Jan Borysowski
Recently, leading medical journals emphasized the importance of further studies on the potential application of bacterial viruses (phages) for the treatment of antibiotics-resistant infections outlining the present status of the therapy and perspectives for the future. Furthermore, a leading scientific journal pointed to the recent progress in research on phage interactions with eukaryotic cells (especially cells of the immune system) and potential implications of their results for our broader understanding of the role of phages - not only as "bacteria eaters" - but also as an important part of our body defense protecting against external and internal pathogenic invaders (as suggested previously)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29652553/mahonia-oiwakensis-extract-and-its-bioactive-compounds-exert-anti-inflammatory-activities-and-vegf-production-through-m2-macrophagic-polarization-and-stat6-activation
#2
Yea-Chen Liu, Yu-Ying Hsiao, Kuo-Lung Ku, Hui-Fen Liao, Wei-Chun Chao
Macrophages play an indispensable role in the host immune defense. Macrophages can undergo polarization into classically (M1) and alternatively (M2) activated macrophages. M1 macrophages activate immune and inflammatory response, while M2 macrophages are involved in tissue remodeling. Mahonia oiwakensis (Mo) is a herbal medicine in Asia used for its anti-inflammatory and analgesic properties; however, the mechanism is unclear. This study analyzed the effect of Mo extracts and its effects on the polarization of both macrophage RAW264...
April 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29642950/melliferous-insects-and-the-uses-assigned-to-their-products-in-the-northern-yungas-of-salta-argentina
#3
Fabio Fernando Flores, Norma Inés Hilgert, Liliana Concepción Lupo
BACKGROUND: The order Hymenoptera comprises melliferous insects (bees, wasps and bumblebees); among them, stingless bees comprise a diverse group of eusocial insects present in tropical and subtropical areas. Of a total of approximately 500 species, 400 are found in the Neotropics. On the continent of America, before the introduction of Apis mellifera, these insects represented the main source of honey and wax. In Argentina, ethnobiological investigations had been carried out on this group of insects, principally in the Atlantic Forest and Chaco regions...
April 11, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29628876/korean-red-ginseng-pretreatment-protects-against-long-term-sensorimotor-deficits-after-ischemic-stroke-likely-through-nrf2
#4
Lei Liu, Mary K Vollmer, Victoria M Fernandez, Yasmin Dweik, Hocheol Kim, Sylvain Doré
Endogenous neuroprotective mechanisms by which the brain protects itself against noxious stimuli and recovers from ischemic damage are key targets of stroke research, ultimately facilitating functional recovery. Transcriptional factor Nrf2, enriched in astrocytes, is a master regulator of endogenous defense systems against oxidative stress and inflammation. Korean Red Ginseng (Ginseng), one most widely used herbal medicine, has exhibited promising potentials in neuroprotection. Our study aimed to determine whether the standardized Ginseng extract pretreatment could attenuate acute sensorimotor deficits and improve long-term functional recovery after ischemic stroke though Nrf2 pathway and whether reactive astrogliosis is associated with such effect...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29618427/amelioration-of-methylmercury-induced-neural-damage-by-essential-oil-of-selinum-vaginatum-edgew-c-b-clarke
#5
Kalaivani Thiagarajan, Naisarg Gamit, Saurabh Mandal, Dhanoop Manikoth Ayyathan, Rajasekaran Chandrasekaran
Methylmercury (MeHg), an organometallic contaminant is a well spotted cause for a series of disorders, especially in the central nervous system. As there is no proper treatment, Selinum vaginatum (Edgew) C. B. Clarke, a traditional medicinal plant, is taken in the present study for assessing its neuroprotective effect against MeHg induced toxicity using rat brain mitochondrial fractions. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide dye (MTT) assay indicated that there was a reduction in the mitochondrial viability in MeHg treated sample and IC50 value recorded was 2...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29615016/using-differential-item-functioning-to-evaluate-potential-bias-in-a-high-stakes-postgraduate-knowledge-based-assessment
#6
David Hope, Karen Adamson, I C McManus, Liliana Chis, Andrew Elder
BACKGROUND: Fairness is a critical component of defensible assessment. Candidates should perform according to ability without influence from background characteristics such as ethnicity or sex. However, performance differs by candidate background in many assessment environments. Many potential causes of such differences exist, and examinations must be routinely analysed to ensure they do not present inappropriate progression barriers for any candidate group. By analysing the individual questions of an examination through techniques such as Differential Item Functioning (DIF), we can test whether a subset of unfair questions explains group-level differences...
April 3, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29604592/quercus-dilatata-lindl-ex-royle-ameliorates-bpa-induced-hepatotoxicity-in-sprague-dawley-rats
#7
Syeda Tayyaba Batool Kazmi, Muhammad Majid, Sonia Maryam, Aymen Rahat, Madiha Ahmed, Muhammad Rashid Khan, Ihsan Ul Haq
Quercus dilatata Lindl. ex Royle was evaluated for in vitro polyphenol content and antioxidant potential as well as in vivo protective role against bisphenol A (BPA) induced hepatotoxicity. The distilled water-acetone (QDDAE) and methanol-ethyl acetate (QDMEtE) extracts were standardized and administered in high (300 mg/kg body weight (BW) and low (150 mg/kg BW) doses to Sprague Dawley rats, injected with BPA (25 mg/kg BW). Silymarin (50 mg/kg BW) was used as positive control. Subsequently, blood and liver homogenates were collected after four weeks of treatment, and the defensive effects of both extracts against oxidative damage and genotoxicity were assessed via hematological and biochemical investigations, determination of endogenous expression of enzymes as well as levels of free radicals and comet assay...
March 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29603614/better-decision-making-in-drug-development-through-adoption-of-formal-prior-elicitation
#8
Nigel Dallow, Nicky Best, Timothy H Montague
With the continued increase in the use of Bayesian methods in drug development, there is a need for statisticians to have tools to develop robust and defensible informative prior distributions. Whilst relevant empirical data should, where possible, provide the basis for such priors, it is often the case that limitations in data and/or our understanding may preclude direct construction of a data-based prior. Formal expert elicitation methods are a key technique that can be used to determine priors in these situations...
March 30, 2018: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/29595675/a-12-year-analysis-of-closed-medical-malpractice-claims-of-the-taiwan-civil-court-a-retrospective-study
#9
Chi-Yuan Hwang, Chien-Hung Wu, Fu-Cheng Cheng, Yung-Lin Yen, Kuan-Han Wu
Malpractices lawsuits cause increased physician stress and decreased career satisfaction, which might result in defensive medicine for avoiding litigation. It is, consequently, important to learn experiences from previous malpractice claims. The aim of this study was to examine the epidemiologic factors related to medical malpractice claims, identify specialties at high risk of such claims, and determine clinical which errors tend to lead to medical malpractice lawsuits, by analyzing closed malpractice claims in the civil courts of Taiwan...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29584636/response-of-plant-secondary-metabolites-to-environmental-factors
#10
REVIEW
Li Yang, Kui-Shan Wen, Xiao Ruan, Ying-Xian Zhao, Feng Wei, Qiang Wang
Plant secondary metabolites (SMs) are not only a useful array of natural products but also an important part of plant defense system against pathogenic attacks and environmental stresses. With remarkable biological activities, plant SMs are increasingly used as medicine ingredients and food additives for therapeutic, aromatic and culinary purposes. Various genetic, ontogenic, morphogenetic and environmental factors can influence the biosynthesis and accumulation of SMs. According to the literature reports, for example, SMs accumulation is strongly dependent on a variety of environmental factors such as light, temperature, soil water, soil fertility and salinity, and for most plants, a change in an individual factor may alter the content of SMs even if other factors remain constant...
March 27, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29581741/extract-of-rhus-verniciflua-stokes-protects-against-renal-ischemia-reperfusion-injury-by-enhancing-nrf2-mediated-induction-of-antioxidant-enzymes
#11
Du Ri Choi, Ji Heun Jeong, Kwang-Sik Yu, Nam-Seob Lee, Young-Gil Jeong, Do Kyung Kim, Chun Soo Na, Dae Seung Na, Won Min Hwang, Seung-Yun Han
Ischemia-reperfusion injury (IRI) may cause acute kidney disease (AKD) by mediating the oxidative stress-induced apoptosis of parenchymal cells. The extract of Rhus verniciflua Stokes (RVS) is used as a traditional herbal medicine as it exhibits anti-oxidant, anti-apoptotic and anti-inflammatory properties. Therefore, the current study investigated the therapeutic effect and the underlying mechanism of RVS on IRI-induced AKD in vivo and in vitro . The current study assessed the effects of RVS on a mouse model of renal IRI and in hypoxic human renal tubular epithelial HK-2 cells...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29580916/influences-on-intentions-to-place-long-acting-reversible-contraceptives-a-pilot-study-comparing-by-provider-specialty-in-ohio
#12
Charee Thompson, Jane Broecker, Maggie Dade, Kelly Nottingham
STUDY OBJECTIVE: According to the American Academy of Pediatrics (AAP), pediatricians are to counsel and provide LARCs as first-line-of-defense contraceptives because they are the most effective. We wanted to explore positive influences on LARC placement for pediatricians, particularly when compared to providers in other specialties who care for women. DESIGN: Survey methods with data analyzed using analyses of variance and general linear models in statistical software SPSS 24...
March 23, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29577583/conscientious-objection-in-reproductive-health-ancient-prerogative-or-harmful-practice
#13
John M Thorp
As the ethics of Medicine arose from philosophical seeds of thought around 500 BC, the Oath of Hippocrates called upon individual physician conscience to place patient well-being first and "do no harm". In the centuries since, this profound statement of ethics has been embraced and molded by Judaism, Islam, Hinduism, and Christianity. It remains pertinent to the vastly different and effective medical practice of the modern world such that many medical schools around the world still incorporate it into the graduation of future physicians...
March 26, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29557933/perspectives-on-patient-safety-and-medical-malpractice-a-comparison-of-medical-and-legal-systems-in-italy-and-the-united-states
#14
Alessandro di Luca, Giuseppe Vetrugno, Vincenzo Lorenzo Pascali, Antonio Oliva, Al Ozonoff
OBJECTIVES: Italy is experiencing a crisis of malpractice litigation with important repercussions on the insurance industry (e.g., lower profits), physicians (e.g., defensive medicine), and the courts (e.g., work backlog, lengthy proceedings). We searched for common ground between legal systems in Italy and the United States and considered the implications for international collaborations in patient safety. METHODS: We examined the judicial frameworks of medical malpractice litigation in two countries with different legal foundations: the United States (a public-private system governed by common law) and Italy (a publicly financed healthcare system governed by civil law)...
March 19, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29557214/current-understanding-and-future-perspectives-of-the-roles-of-sirtuins-in-the-reprogramming-and-differentiation-of-pluripotent-stem-cells
#15
Yi-Chao Hsu, Yu-Ting Wu, Chia-Ling Tsai, Yau-Huei Wei
In mammalian cells, there are seven members of the sirtuin protein family (SIRT1-7). SIRT1, SIRT6, and SIRT7 catalyze posttranslational modification of proteins in the nucleus, SIRT3, SIRT4, and SIRT5 are in the mitochondria and SIRT2 is in the cytosol. SIRT1 can deacetylate the transcription factor SOX2 and regulate induced pluripotent stem cells (iPSCs) reprogramming through the miR-34a-SIRT1-p53 axis. SIRT2 can regulate the function of pluripotent stem cells through GSK3β. SIRT3 can positively regulate PPAR gamma coactivator 1-alpha (PGC-1α) expression during the differentiation of stem cells...
March 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29553009/the-compleat-physician-and-experimentation-in-medicines-everard-maynwaring-c-1629-1713-and-the-restoration-debate-on-medical-practice-in-london
#16
Jonathan Barry
Restoration London saw a wave of publications by physicians advocating that the 'compleat physician' should be one who experimented and produced his own medicines. Only thus, they argued, could the medical hierarchy be restored and medical authority re-established on a defensible basis. This article seeks to explain the context for this unusual approach, and why it failed to attract mainstream physicians by the end of the century, by considering the sixty-year career of one of its leading advocates, Everard Maynwaring (c...
April 2018: Medical History
https://www.readbyqxmd.com/read/29547914/medical-attrition-from-commanders-training-in-the-israeli-defense-forces-idf-a-cross-sectional-study-on-23-841-soldiers
#17
Oren Schwartz, Boris Kanevsky, M A J Sergey Kutikov, Cara H Olsen, Israel Dudkiewicz
Introduction: Attrition from training is associated with substantial financial and personnel loss. There is a plethora of medical literature and research of attrition rates related to initial/phase 1 training (basic combat training); however, the analysis of second phase training (commanders training, consisting of schools that qualify junior commanders and officers for infantry and non-infantry combat units) is limited. The purpose of this study is to perform a comprehensive survey regarding to medical attrition from commanders training in the IDF (Israeli Defense Forces) in order to present the commanders of the IDF a detailed situation report that will serve as an evidence-based platform for future policy planning and implementation...
March 14, 2018: Military Medicine
https://www.readbyqxmd.com/read/29536927/medical-errors-malpractice-and-defensive-medicine-an-ill-fated-triad
#18
Leonard Berlin
For the first 180 years following the founding of the US, physicians occasionally were sued for medical malpractice. Allegations of negligence were errors of commission - i.e. the physician made a mistake by doing something wrong, usually mistreatment of a fracture or dislocation, a complication or death following a surgical procedure, prescribing the wrong medication, and after the discovery of the X-ray by Roentgen in 1895, causing radiation burns. In the mid twentieth century malpractice allegations slowly changed from errors of commission to errors of omission - i...
September 26, 2017: Diagnosis
https://www.readbyqxmd.com/read/29534408/-chinese-expert-consensus-on-tetanus-immunization
#19
(no author information available yet)
Tetanus is an acute specific infection caused by obligate anaerobes, which is still a serious public health problem. Tetanus bacterium is an obligate anaerobic bacterium, widely distributed in nature, which can exist in dust, soil, human or animal excrement. The bacteria invade the body primarily through the skin or mucosal wounds, and most commonly in trauma and burn patients, unclean newborns, and unsafe surgical instruments. Exotoxin produced by tetanus bacteria can cause temporary changes in the central nervous system, manifested as systemic skeletal muscle persistence and paroxysmal spasm, severe cases of laryngospasm, asphyxia, lung infections and organ failure, which is a very serious and potentially fatal disease...
March 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29526534/ivc-filter-malpractice-litigation-damned-if-you-do-damned-if-you-don-t
#20
John Phair, John Denesopolis, Evan C Lipsitz, Larry Scher
OBJECTIVE: To analyze malpractice litigation trends and to better understand the causes and outcomes of suits involving inferior vena cava filters (IVCF) to prevent future litigation and improve physician education. METHODS: Jury verdict reviews from the WESTLAW database from January 1st 2000 to December 31st 2015 were reviewed. The search term "inferior vena cava filter" was used to compile data on the demographics of the defendant, plaintiff, allegation, complication, and verdict...
March 8, 2018: Annals of Vascular Surgery
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