keyword
MENU ▼
Read by QxMD icon Read
search

Defensive medicine

keyword
https://www.readbyqxmd.com/read/28079933/co-expression-of-peppermint-geranyl-diphosphate-synthase-small-subunit-enhances-monoterpene-production-in-transgenic-tobacco-plants
#1
Jun-Lin Yin, Woon-Seng Wong, In-Cheol Jang, Nam-Hai Chua
Monoterpenes are important for plant survival and useful to humans. In addition to their function in plant defense, monoterpenes are also used as flavors, fragrances and medicines. Several metabolic engineering strategies have been explored to produce monoterpene in tobacco but only trace amounts of monoterpenes have been detected. We investigated the effects of Solanum lycopersicum 1-deoxy-d-xylulose-5-phosphate synthase (SlDXS), Arabidopsis thaliana geranyl diphosphate synthase 1 (AtGPS) and Mentha × piperita geranyl diphosphate synthase small subunit (MpGPS...
February 2017: New Phytologist
https://www.readbyqxmd.com/read/28078741/effect-of-an-art-brut-therapy-program-called-go-beyond-the-schizophrenia-gbts-on-prison-inmates-with-schizophrenia-in-mainland-china-a-randomized-longitudinal-and-controlled-trial
#2
Hong-Zhong Qiu, Zeng-Jie Ye, Mu-Zi Liang, Yue-Qun Huang, Wei Liu, Zhi-Dong Lu
: Creative arts therapies are proven to promote an interconnection between body and mind, but there are major obstacles for providing therapeutic services in prisons due to inmates' inherent mistrust for verbal disclosure and rigid self-defenses, especially among inmates with schizophrenia. Thus, we developed a structured and quantitative art brut therapy program called go beyond the schizophrenia to actually measure the benefits of art therapy on prison inmates in mainland China. Upon completion of the program, the intervention group reported a decrease in anxiety, depression, anger, and negative psychiatric symptoms and showed better compliance with rules, socialization with peers, compliance with medications, and regular sleeping patterns after 16 weekly sessions of go beyond the schizophrenia...
January 12, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28066109/cerebroprotective-activity-of-pentapetes-phoenicea-on-global-cerebral-ischemia-in-rats
#3
Koneru Naga Sravanthi, Nadendla Rama Rao
OBJECTIVES: The study was performed to evaluate the cerebroprotective activity of methanolic extract (ME) of Pentapetes phoenicea - a folk medicine used as anti-inflammatory and in central nervous system ailments. It has high phenolic and flavonoid contents including rutin. MATERIALS AND METHODS: Global cerebral ischemia was induced in male albino Wistar rats by temporary bilateral carotid artery occlusion (BCAO) for 30 min, followed by 4 h reperfusion. Groups of rats were pretreated for 10 days with 100, 200, and 400 mg/kg of ME of P...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28060984/-saints-in-medicine-during-the-great-wars-of-the-twentieth-century
#4
María Agustina Martini, Bárbara C Finn, Julio E Bruetman, Pablo Young
In the political and social context of World War periods and unstoppable technological advances, health professionals in the early twentieth century tried to orientate the practice of medicine towards a modern anthropological concept close to the biomedical perspective, which defends the dignity of a person. Threatened by the risks represented by collectivism and the meanness of the prevailing repressive governments, a personal struggle for the defense of life aroused, which was socially expressed by the advent of bioethics, psychoanalytic theories and the concept that environment has an important role in people’s health and welfare...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28051966/operational-perspective-of-lessons-learned-from-the-ebola-crisis
#5
Zygmunt F Dembek, Jerry L Mothershead, Tesema Chekol, David B Myers, Ronald G Meris, Dana Meranus, Aiguo Wu
Given its potential to quickly spread internationally and initially uncontrollable nature, the 2014 to 2015 Ebola outbreak has implications for global biosecurity. The Defense Threat Reduction Agency's Technical Reachback provided near real-time analysis and recommendations as outbreak-relevant events unfolded. Our review of often-conflicting or incomplete information was required to answer policy decision makers about the expanding Ebola epidemic, and enable the formulation of best-possible U.S. Department of Defense and Government response...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28050797/debates-about-conflict-of-interest-in-medicine-deconstructing-a-divided-discourse
#6
Serena Purdy, Miles Little, Christopher Mayes, Wendy Lipworth
The pharmaceutical industry plays an increasingly dominant role in healthcare, raising concerns about "conflicts of interest" (COI) on the part of the medical professionals who interact with the industry. However, there is considerable disagreement over the extent to which COI is a problem and how it should be managed. Participants in debates about COI have become entrenched in their views, which is both unproductive and deeply confusing for the majority of medical professionals trying to work in an increasingly commercialized environment...
January 3, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28049396/oxidative-stress-and-antioxidant-potential-of-one-hundred-medicinal-plants
#7
Waseem Hassan, Hamsa Noreen, Shakila Rehman, Shehnaz Gul, Mohammad Amjad Kamal, Jean Paul Kamdem, Bakht Zaman, Joao B T da Rocha
Reactive species are produced in biological system because of redox reactions. The imbalance in pro-oxidant and antioxidant homeostasis leads to the production of toxic reactive oxygen and nitrogen species like hydrogen peroxide, organic peroxides, hydroxyl radicals, superoxide anion and nitric oxide. Inactivation of metabolic enzymes, oxidation of biomolecules and cellular damage are some of the prominent characteristics of reactive species. Similarly, oxidative stress has been associated with more than one hundred (100) pathologies such as atherosclerosis, diabetes, cardiovascular diseases, pancreatic and liver diseases, joint disorders, cardiac fibrosis, acute respiratory distress syndrome, neurological diseases (amyotrophic lateral sclerosis, Huntington's disorder, Parkinson's disease and Alzheimer's disease), ageing and cancer etc...
January 2, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28043593/new-approaches-in-drug-treatment-for-tuberculosis-inhalation-using-liposomes-only-a-future-vision-or-soon-in-clinical-practice
#8
Lars-Olof Larsson
A major change of therapy in respiratory medicine has been the transition from oral or parenteral to inhalation therapy, for example, in asthma. Inhalation of anti-infectious drugs has however not a key-role in the treatment of pulmonary infections such as tuberculosis (TB). The inhalation therapy provides several benefits; the target is reached directly with evasion of first-pass metabolism, thereby resulting in reduced systemic side effects. Furthermore, the drug is delivered to an extensive surface area that is rich in lymphoid tissue...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042926/the-potential-impact-of-gut-microbiota-on-your-health-current-status-and-future-challenges
#9
Stitaya Sirisinha
Our health and probably also our behaviors and mood depend not only on what we eat or what we do (lifestyle behaviors), but also on what we host. It is well established for decades that all vertebrates including humans are colonized by a wide array of bacteria, fungi, eukaryotic parasites and viruses, and that, at steady state (homeostasis), this community of microbes establishes a friendly mutual relationship with the host. The term microbiota was originally meant to represent an ecological community of commensals and potentially pathogenic microbes that live within our bodies, but it is now used interchangeably with the term microbiome which was initially meant to represent a collective genome of the microbiota...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28039833/accumulation-efficiency-genotoxicity-and-antioxidant-defense-mechanisms-in-medicinal-plant-acalypha-indica-l-under-lead-stress
#10
Perumal Venkatachalam, Narayanan Jayalakshmi, Natesan Geetha, Shivendra V Sahi, Nilesh C Sharma, Eldon R Rene, Santosh K Sarkar, Paulo J C Favas
The present study was designed to assess the physiological and biochemical changes in roots and shoots of the herb Acalypha indica grown under hydroponic conditions during exposure to lead (Pb) (100-500 mg L(-1)) for 1-12 d. The accumulation of Pb by A. indica plants was found to be 121.6 and 17.5 mg g(-1) dry weight (DW) in roots and shoots, respectively, when exposed to a Pb concentration of 500 mg L(-1). The presence of Pb ions in stem, root and leaf tissues was confirmed by scanning electron microscope (SEM) and Energy-dispersive X-ray spectroscopy (EDX) analyses...
December 20, 2016: Chemosphere
https://www.readbyqxmd.com/read/28035418/realgar-transforming-solution-displays-anticancer-potential-against-human-hepatocellular-carcinoma-hepg2-cells-by-inducing-ros
#11
Peng Song, Peng Chen, Dong Wang, Zhengrong Wu, Qiyu Gao, Aixia Wang, Ruilan Zhu, Yajun Wang, Xin Wang, Longhe Zhao, Ziyun Duan, Shuqian Zhu, Peng Cui, Yang Li, Hongyu Li
Realgar (As4S4), as a mineral drug containing arsenic compound, has been employed in clinical therapy of cancer for its good therapeutic reputation in Chinese traditional medicine. However, large dose of realgar and long period of treatment are necessary for achieving the effective blood medicine concentration due to its low bioavailability resulted from poor solubility. In this study, we obtained realgar transforming solution (RTS) using intrinsic biotransformation in microorganism, and investigated underlying mechanisms of RTS for HepG2 cells...
December 30, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/28027824/protective-effect-of-chamomile-matricaria-recutita-l-decoction-extract-against-alcohol-induced-injury-in-rat-gastric-mucosa
#12
Mohamed-Amine Jabri, Nadhem Aissani, Haifa Tounsi, Mohsen Sakly, Lamjed Marzouki, Hichem Sebai
BACKGROUND: Matricaria recutita L. (Asteraceae), German chamomile, has been widely used in the traditional Tunisian medicine because of having the powerful health benefits. the current study was conducted to determine the protective effect of chamomile (Matricaria recutita L.) decoction extract (CDE) in ethanol-induced ulcer and oxidative stress on gastric mucosa in rat. METHODS: Adult male wistar rats were used and divided into seven groups: Control, EtOH, EtOH+various doses of CDE (25, 50 and 100mg/kg, b...
December 21, 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28027167/meeting-the-needs-of-the-nation-for-radiation-protection-summary-of-the-52nd-annual-meeting-of-the-national-council-on-radiation-protection-and-measurements
#13
Richard E Toohey
The 52nd Annual Meeting of the National Council on Radiation Protection and Measurements (NCRP) was held in Bethesda, MD, 11-12 April 2016, on the topic of "Meeting National Needs for Radiation Protection." This meeting was an outgrowth of the NCRP initiative "Where are the Radiation Professionals?" (WARP), which addresses looming shortages in professional personnel trained in the radiological disciplines, including but not limited to health physics, radiological engineering, radiobiology, radiochemistry, radioecology, radiation emergency response; and the medical disciplines of diagnostic and interventional radiology, radiation oncology, nuclear medicine, and medical physics...
February 2017: Health Physics
https://www.readbyqxmd.com/read/28017773/antileishmanial-activity-of-verbascoside-selective-arginase-inhibition-of-intracellular-amastigotes-of-leishmania-leishmania-amazonensis-with-resistance-induced-by-lps-plus-ifn-%C3%AE
#14
Claudia do Carmo Maquiaveli, Arina Lázaro Rochetti, Heidge Fukumasu, Paulo Cezar Vieira, Edson Roberto da Silva
Verbascoside is the main component of the traditional medicinal plants that were used against protozoa parasites that cause malaria and leishmaniasis. Previously, we have described verbascoside inhibition of Leishmania amazonensis arginase as well as its antileishmanial action against extracellular promastigotes. In this study, we have assessed arginase parasite inhibition in intracellular amastigotes. In addition, we verified whether verbascoside can influence the host defense against the parasite by measuring gene expression of cytokines IL-1b, IL-10, IL-18, TNF-α and murine macrophage arginase as well as nitric oxide synthase enzymes...
December 23, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28012441/ugonin-u-stimulates-nlrp3-inflammasome-activation-and-enhances-inflammasome-mediated-pathogen-clearance
#15
Chun-Yu Chen, Chuan-Hui Yang, Yung-Fong Tsai, Chih-Chuang Liaw, Wen-Yi Chang, Tsong-Long Hwang
The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome contains Nod-like receptors, a subclass of pattern recognition receptors, suggesting that this complex has a prominent role in host defenses. Various structurally diverse stimulators activate the NLRP3 inflammasome through different signaling pathways. We previously reported that ugonin U (UgU), a natural flavonoid isolated from Helminthostachys zeylanica (L) Hook, directly stimulates phospholipase C (PLC) and triggers superoxide release in human neutrophils...
December 18, 2016: Redox Biology
https://www.readbyqxmd.com/read/28011434/facile-and-green-synthesis-of-phytochemicals-capped-platinum-nanoparticles-and-in-vitro-their-superior-antibacterial-activity
#16
Kamran Tahir, Sadia Nazir, Aftab Ahmad, Baoshan Li, Arif Ullah Khan, Zia Ul Haq Khan, Faheem Ullah Khan, Qudrat Ullah Khan, Abrar Khan, Aziz Ur Rahman
The increase in the severe infectious diseases and resistance of the majority of the bacterial pathogens to the available drug is a serious problem now a day. In order to overcome this problem it is necessary to develop new therapeutic agents which are non-toxic and more effective to inhibit these microbial pathogens. For this purpose the plant extract of highly active medicinal plant, Taraxacum laevigatum was used for the synthesis of platinum nanoparticles (PtNPs) to enhance its bio-activities. The surface plasmon resonance peak appeared at 283nm clearly represent the formation of PtNPs...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28011159/the-impact-of-state-tort-reforms-on-imaging-utilization
#17
Suhui Li, Avi Dors, Darwyyn Deyo, Danny R Hughes
PURPOSE: Defensive medicine, broadly defined as medical practices that protect physicians from malpractice lawsuits without providing benefits to patients, can lead to wasteful use of health care resources and higher cost. Although physicians cite malpractice liability as an important factor driving their decisions to order imaging tests, little research has been done to examine the systematic impact of liability pressure on overall imaging. The authors examined the extent to which radiography use is influenced by malpractice liability pressure among office-based physicians...
December 20, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28004651/autophagy-a-brief-overview-in-perspective-of-dermatology
#18
REVIEW
Rahul Nagar
Autophagy, literally meaning "self-eating," is an intracellular catabolic process of delivering cytosol and/or its specific content to the lysosomes for degradation.The resulting macromolecular constituents are recycled and utilized again by the cells. Basal level autophagy plays an important role in cellular homeostasis through the elimination of the old or damaged organelles, as well as aggregated intracellular proteins. Autophagy refers to sequestration of intact organelles along with a portion of cytosol, into a double-or multi-membrane structure known as phagophore, which elongates, and after closure, forms a vesicular structure known as the autophagosome...
December 20, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28001177/uromodulin-a-new-biomarker-of-fetal-renal-function
#19
Thais Emanuelle Faria Botelho, Alamanda Kfoury Pereira, Patrícia Gonçalves Teixeira, Eura Martins Lage, Gabriel Costa Osanan, Ana Cristina Simões E Silva
INTRODUCTION: Obstructive uropathies are main diseases affecting the fetus. Early diagnosis allows to establish the appropriate therapy to minimize the risk of damage to kidney function at birth. Biochemical markers have been used to predict the prognosis of renal function in fetuses. Uromodulin, also known by Tamm-Horsfall protein (THP) is exclusively produced in the kidneys and in normal conditions is the protein excreted in larger amounts in human urine. It plays important roles in kidneys and urinary tract...
December 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/27999408/cyclodextrins-as-emerging-therapeutic-tools-in-the-treatment-of-cholesterol-associated-vascular-and-neurodegenerative-diseases
#20
REVIEW
Caroline Coisne, Sébastien Tilloy, Eric Monflier, Daniel Wils, Laurence Fenart, Fabien Gosselet
Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism. Therefore, innovative pharmacological approaches aiming at counteracting cholesterol imbalance display promising therapeutic potential. However, these approaches need to take into account the existence of biological barriers such as intestinal and blood-brain barriers which participate in the organ homeostasis and are major defense systems against xenobiotics...
December 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
41527
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"