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https://www.readbyqxmd.com/read/29145097/lc-esi-ms-ms-determination-of-defactinib-a-novel-fak-inhibitor-in-mice-plasma-and-its-application-to-a-pharmacokinetic-study-in-mice
#1
Gurulingappa Hallur, Natarajan Tamizharasan, Suresh P Sulochana, Neeraj Kumar Saini, Mohd Zainuddin, Ramesh Mullangi
A sensitive, specific, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of defactinib in mice plasma using (13)C3,(15)N-tofacitinib as an internal standard (I.S.). Sample preparation was accomplished through a liquid-liquid extraction process. Baseline chromatographic resolution of defactinib and the I.S. was achieved on an Atlantis dC18 column using an isocratic mobile phase comprising 0.2% formic acid in water and acetonitrile (25:75, v/v) delivered at a flow rate of 0...
November 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29144552/simultaneous-determination-of-tilianin-and-its-metabolites-in-mice-using-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry-and-its-application-to-a-pharmacokinetic-study
#2
Liping Wang, Qingwei Chen, Lijun Zhu, Xuejun Zeng, Qiang Li, Ming Hu, Xinchun Wang, Zhongqiu Liu
Tilianin is an active flavonoid glycoside found in many medical plants. Data are lacking regarding its pharmacokinetics and disposition in vivo. The objective of this study was to develop a sensitive, reliable, and validated ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) method to simultaneously quantify tilianin and its main metabolites and to determine its pharmacokinetics in wild-type and breast cancer resistance protein knockout (Bcrp1-/-) FVB mice. Chromatographic separation was accomplished on a C18 column by utilizing acetonitrile and 0...
November 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29143972/determination-of-tubuloside-b-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study-in-rats
#3
Shenbao Yang, Ruiying Qu, Peilu Sun, Shan Xiong, Siyi Yan, Zhipeng Deng
Tubuloside B, a novel neuroprotective phenylethanoid, is a major active constituent of Cistanche tubulosa and Cistanche deserticola. A specific and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of tubuloside B in rat plasma. Sample preparation was conducted through a protein-precipitation extraction with methanol using tubuloside A as internal standard (IS). Chromatographic separation was achieved by using a Capcell Pak C18 column (2...
November 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29143900/an-innovative-mobile-health-system-to-improve-and-standardize-antenatal-care-among-underserved-communities-a-feasibility-study-in-an-italian-hosting-center-for-asylum-seekers
#4
Lucia Borsari, Giovanna Stancanelli, Laura Guarenti, Teresa Grandi, Serena Leotta, Lucia Barcellini, Paola Borella, Anne Caroline Benski
Innovative migrant-friendly tools are needed to assist health personnel manage the high number of pregnancies within reception centers. This study tests functionality and acceptability of a new mHealth system in providing antenatal care amongst migrants. The study, carried out between 2014 and 2016, involved 150 pregnant women residing in the largest European migrant reception center in Sicily. A ticket tracking system assessed the system's functionality and a questionnaire assessed women's acceptability. The system facilitated the collection of clinical data, enabling the creation of electronic patient records and identifying 10% of pregnancies as high-risk...
November 16, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29142283/a-mobile-device-based-imaging-spectrometer-for-environmental-monitoring-by-attaching-a-lightweight-small-module-to-a-commercial-digital-camera
#5
Fuhong Cai, Wen Lu, Wuxiong Shi, Sailing He
Spatially-explicit data are essential for remote sensing of ecological phenomena. Lately, recent innovations in mobile device platforms have led to an upsurge in on-site rapid detection. For instance, CMOS chips in smart phones and digital cameras serve as excellent sensors for scientific research. In this paper, a mobile device-based imaging spectrometer module (weighing about 99 g) is developed and equipped on a Single Lens Reflex camera. Utilizing this lightweight module, as well as commonly used photographic equipment, we demonstrate its utility through a series of on-site multispectral imaging, including ocean (or lake) water-color sensing and plant reflectance measurement...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141447/what-is-offered-on-mobile-applications-in-spanish-about-diabetes-mellitus
#6
Paul Jesús Tejada-Llacsa, Stalin Yance-Contreras, Leidy Machuca-Felipa, Carlos A Cordova-Cassia
No abstract text is available yet for this article.
November 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29140618/utah-regional-differences-in-respirator-use-and-fit-testing-among-pesticide-applicators
#7
Michael L Pate, F Richard Beard, Kelsey Hall
The purpose of this study was to determine regional differences within Utah in response to piloting a mobile respirator training and fit assessment program for pesticide applicators. The objectives were to describe worker perceptions of respirator use and training experiences. Pilot trainings were offered in two southern counties and two northern counties of Utah. A total of 141 individuals completed the post-training questionnaire regarding use and fit testing experience with respirators as well as perceptions of the benefits to protecting respiratory health...
January 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29140434/managing-public-health-data-mobile-applications-and-mass-vaccination-campaigns
#8
Melissa W McClung, Sarah A Gumm, Megan E Bisek, Amber L Miller, Bryan C Knepper, Arthur J Davidson
In response to data collection challenges during mass immunization events, Denver Public Health developed a mobile application to support efficient public health immunization and prophylaxis activities. The Handheld Automated Notification for Drugs and Immunizations (HANDI) system has been used since 2012 to capture influenza vaccination data during Denver Health's annual employee influenza campaign. HANDI has supported timely and efficient administration and reporting of influenza vaccinations through standardized data capture and database entry...
November 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29139070/mobile-health-application-and-e-health-literacy-opportunities-and-concerns-for-cancer-patients-and-caregivers
#9
Hyunmin Kim, Joy V Goldsmith, Soham Sengupta, Asos Mahmood, M Paige Powell, Jay Bhatt, Cyril F Chang, Soumitra S Bhuyan
Health literacy is critical for cancer patients as they must understand complex procedures or treatment options. Caregivers' health literacy also plays a crucial role in caring for cancer patients. Low health literacy is associated with low adherence to medications, poor health status, and increased health care costs. There is a growing interest in the use of mobile health applications (apps) to improve health literacy. Mobile health apps can empower underserved cancer patients and their caregivers by providing features or functionalities to enhance interactive patient-provider communication and to understand medical information more readily...
November 14, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29138051/sarcopenia-in-peripheral-arterial-disease-prevalence-and-impact-on-functional-status
#10
Odessa Addison, Steven J Prior, Rishi Kundi, Monica C Serra, Leslie I Katzel, Andrew W Gardner, Alice S Ryan
OBJECTIVES: To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD) and to compare to a subset of the group to age, race, sex, and body mass index (BMI)-matched non-PAD control counterparts. We also sought to compare the functional status of those with PAD with and without sarcopenia. DESIGN: Cohort study. SETTING: A Veterans Affairs medical center. PARTICIPANTS: Sedentary, community dwelling men age 50+ years with a confirmed diagnosis of PAD (N=108; 44% black; BMI 27...
November 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29138050/a-systematic-review-on-the-effect-of-serious-games-and-wearable-technology-used-in-rehabilitation-of-patients-with-traumatic-bone-and-soft-tissue-injuries
#11
REVIEW
Henriëtte A W Meijer, Maurits Graafland, J Carel Goslings, Marlies P Schijven
OBJECTIVE: To determine the effects on functional outcomes and treatment adherence of wearable technology and serious games (i.e., interactive computer applications with specific purposes useful in the 'real world') currently applied in physical rehabilitation of patients after traumatic bone and soft tissue injuries. DATA SOURCES: PubMed, Embase, the Cochrane Library and CINAHL were searched without publication date restrictions for the terms 'wearable', 'serious game', 'videogame' or 'mobile application', and 'rehabilitation', 'exercise therapy' or 'physiotherapy'...
November 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29137798/experimental-study-on-viscosity-reduction-for-residual-oil-by-ultrasonic
#12
Xintong Huang, Cuihong Zhou, Quanyu Suo, Lanting Zhang, Shihan Wang
Because of characteristics of large density, high viscosity and poor mobility, the processing and transportation of residual oil are difficult and challenging, viscosity reduction of residual oil is of great significance. In this paper, the effects of different placement forms of ultrasonic transducers on the sound pressure distribution of ultrasonic inside a cubic container have been simulated, the characteristics of oil bath heating and ultrasonic viscosity reduction were compared, viscosity reduction rule of residual oil was experimentally analyzed by utilizing Response Surface Method under conditions of changing ultrasonic exposure time, power and action mode, the mechanism of viscosity reduction was studied by applying Fourier transform infrared spectrometer, the viscosity retentivity experiment was carried out at last...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137502/innovative-product-development-partnership-reduced-neonatal-mortality-in-nepal-through-improved-umbilical-cord-care
#13
Peter Oyloe, Leela Khanal, Stephen Hodgins, Sabita T Pradhan, Penny Dawson
Approximately 40 percent of all newborn deaths in Nepal are attributable to neonatal infections. A randomized controlled trial conducted in Nepal in the period 2002-05 on the application of a solution of the disinfectant chlorhexidine to umbilical cord stumps of newborns showed a reduced risk of infections and death. In response to these results, the Government of Nepal and various partners mobilized to deliver this simple, low-cost intervention on a national scale. We describe the design, development, and maturation of a partnership among the government, technical assistance agencies, and a local pharmaceutical company to create a suitable, commercially available gel product to reduce newborn infections...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29136872/a-novel-hybrid-flow-platform-for-on-line-simultaneous-dynamic-fractionation-and-evaluation-of-mercury-lability-in-environmental-solids
#14
Yanlin Zhang, Manuel Miró, Spas D Kolev
A method for the automatic simultaneous assessment of mobility and lability of mercury in environmental solid samples has been developed for the first time. It has been implemented in a hybrid flow system integrating flow-through dynamic sequential extraction and on-line chemical digestion prior to atomic fluorescence detection. The method allows the determination of trace concentrations of labile mercury (HgL) and non-labile mercury (HgNL) in different bioaccessible phases of environmental solid samples thus providing expeditious data not only for Hg exposome studies but also for the selection of suitable environmental remediation techniques...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136817/rapid-quantification-of-persulfate-in-aqueous-systems-using-a-modified-hplc-unit
#15
Abbas Baalbaki, Nagham Zein Eddine, Saly Jaber, Maya Amasha, Antoine Ghauch
Existing analytical techniques used for the quantification of persulfate (PS) in water mostly rely on polarography, reductometry or spectrophotometry. Although acceptable to a certain extent, these methods did not satisfy environmental chemists seeking rapid, reproducible and accurate quantification of PS upon the application of ISCO and AOPs technologies. Accordingly, a novel flow injection/spectroscopy analytical technique is developed via the use of an HPLC coupled to bypass capillary columns and a DAD detector...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136580/advancing-the-large-scale-ccs-database-for-metabolomics-and-lipidomics-at-the-machine-learning-era
#16
REVIEW
Zhiwei Zhou, Jia Tu, Zheng-Jiang Zhu
Metabolomics and lipidomics aim to comprehensively measure the dynamic changes of all metabolites and lipids that are present in biological systems. The use of ion mobility-mass spectrometry (IM-MS) for metabolomics and lipidomics has facilitated the separation and the identification of metabolites and lipids in complex biological samples. The collision cross-section (CCS) value derived from IM-MS is a valuable physiochemical property for the unambiguous identification of metabolites and lipids. However, CCS values obtained from experimental measurement and computational modeling are limited available, which significantly restricts the application of IM-MS...
November 11, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29132854/price-discrepancies-among-mobile-medication-applications-for-common-dermatologic-prescriptions-observational-cost-analysis
#17
Hershel E Dobkin, Matthew Zirwas
No abstract text is available yet for this article.
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29131732/yoga-and-healthcare-in-the-united-kingdom
#18
Heather Mason, Nicole Schnackenberg, Robin Monro
The emergence of yoga therapy in the United Kingdom began about 45 years ago with the emergence of yoga therapy organizations that offered both treatment and training. The integration of yoga into the National Health Service (NHS) is gradually happening Because: (a) yoga research supports its efficacy as a cost-effective, preventive and complementary treatment for a host of non-communicable diseases; and (b) the escalating economic burden of long-term conditions is overwhelming the NHS. The NHS is actively developing 'sustainability and transformation plans' that include yoga...
November 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/29131174/tunable-graphene-plasmonic-y-branch-switch-in-the-terahertz-region-using-hexagonal-boron-nitride-with-electric-and-magnetic-biasing
#19
Ali Farmani, Mahdi Yavarian, Abbas Alighanbari, Mehdi Miri, Mohammad H Sheikhi
A tunable graphene plasmonic Y-branch switch at THz wavelengths is proposed. The effects of magnetic and electric biasing are studied to harness the transmission of the transverse electric and magnetic guided mode resonances. In the structure, hexagonal boron nitride is utilized as a substrate for graphene. The application of hexagonal boron nitride, with the advantages of high mobility and ultralow ohmic loss, introduces a promising alternative substrate for graphene. Analytical and numerical results show that, by slight variation of the doping level in graphene through magnetic and electric biasing, the characteristics of the propagation of the guided mode resonances can be manipulated...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29130960/piwi-proteins-and-piwi-interacting-rna-emerging-roles-in-cancer
#20
Yi-Neng Han, Yuan Li, Sheng-Qiang Xia, Yuan-Yuan Zhang, Jun-Hua Zheng, Wei Li
P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control...
November 3, 2017: Cellular Physiology and Biochemistry
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