keyword
https://read.qxmd.com/read/38269428/perioperative-and-complication-related-outcomes-for-robotic-assisted-versus-open-radical-cystectomy-a-comparative-nsqip-analysis
#21
JOURNAL ARTICLE
Rishabh Kumar Simhal, Daniel P Simon, Kerith R Wang, Yash B Shah, Brandon Havranek, James Ryan Mark, Thenappan Chandrasekar, Mihir S Shah, Costas D Lallas
Radical cystectomy (RC) is standard of care for muscle-invasive bladder cancer, but it comes with significant perioperative risk. Currently, both open radical cystectomies (ORC) and RARC are frequently performed. Using newly available data from the American College of Surgeons National Surgical Quality Improvement Project (NSQIP), we aim to compare 30-day outcomes between patients who received ORC or RARC, representing one of the largest, most recent multi-institutional studies comparing these operative approaches...
January 25, 2024: Journal of Endourology
https://read.qxmd.com/read/38266378/remote-paediatric-ear-examination-comparing-video-otoscopy-and-still-otoscopy-clinician-rated-outcomes
#22
JOURNAL ARTICLE
Mark E Quick, Christopher G Brennan-Jones, Jafri Kuthubutheen
OBJECTIVE: Telemedicine, particularly real time video-otoscopy in rural and remote Australia holds great potential in assessing and managing otology conditions. There is good evidence of store and forward images for assessment, however limited evidence exists for the use of real-time video-otoscopy. The objective of this study was to assess the validity of using real time video-otoscopy, compared to standard store and forward still image otoscopy, in a paediatric population. METHOD: Fifty-two paediatric tympanic membranes in 27 patients were examined and photographed by a telehealth facilitator with prior otoscope training...
January 17, 2024: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38245897/development-and-validation-of-the-phoenix-criteria-for-pediatric-sepsis-and-septic-shock
#23
JOURNAL ARTICLE
L Nelson Sanchez-Pinto, Tellen D Bennett, Peter E DeWitt, Seth Russell, Margaret N Rebull, Blake Martin, Samuel Akech, David J Albers, Elizabeth R Alpern, Fran Balamuth, Melania Bembea, Mohammod Jobayer Chisti, Idris Evans, Christopher M Horvat, Juan Camilo Jaramillo-Bustamante, Niranjan Kissoon, Kusum Menon, Halden F Scott, Scott L Weiss, Matthew O Wiens, Jerry J Zimmerman, Andrew C Argent, Lauren R Sorce, Luregn J Schlapbach, R Scott Watson, Paolo Biban, Enitan Carrol, Kathleen Chiotos, Claudio Flauzino De Oliveira, Mark W Hall, David Inwald, Paul Ishimine, Michael Levin, Rakesh Lodha, Simon Nadel, Satoshi Nakagawa, Mark J Peters, Adrienne G Randolph, Suchitra Ranjit, Daniela Carla Souza, Pierre Tissieres, James L Wynn
IMPORTANCE: The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis and septic shock using measures of organ dysfunction through a data-driven approach. OBJECTIVE: To derive and validate novel criteria for pediatric sepsis and septic shock across differently resourced settings. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, international, retrospective cohort study in 10 health systems in the US, Colombia, Bangladesh, China, and Kenya, 3 of which were used as external validation sites...
February 27, 2024: JAMA
https://read.qxmd.com/read/38213222/histopathological-tracing-of-hpv-genotypes-6-and-11-in-pediatric-patients-in-medical-city-with-chronic-palatine-and-pharyngeal-tonsillitis
#24
JOURNAL ARTICLE
Azzam M Abbas, Ahmed M Rasheed, Shamil A Hilal, Saad H Mohammed-Ali, Shakir H M Al-Alwany, Athraa Y Al-Hijazi, Khalil I Abid-Mohammed
BACKGROUND: HPVs are considered to have high-oncogenic risk. These genotypes have been proven to have a causal link to cancers, in pediatric and youth patients, with high rates of HPV presence in the tonsillar tissues. OBJECTIVE: A prospective case-control research for determining HPV 6/11 genotypes in tonsillar specimens of children who underwent operations in the otolaryngology departments of the Medical City Complex, Baghdad, Iraq, for their non-oncologic palatine and pharyngeal tonsillar hypertrophies...
January 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38206875/piloting-delivery-of-pfspz-vaccines-for-malaria-through-a-cryogenic-vaccine-cold-chain-to-travel-and-military-medicine-clinics
#25
JOURNAL ARTICLE
Eric R James, L W Preston Church, Stephen L Hoffman, Brian D Robertson, Patrick W Hickey, C O L David J Schwartz, P O Patrick T Logan, Theresa D Asare, Macie L Jones, L T C Jeannie L Bay, Austin K Roschel, Jacqueline L Pfeiffer, Rebecca W Acosta, Ethan Schiavi, Alberto M Acosta, Mark Noble, Thomas Henkel, Cebrina Young
BACKGROUND: PfSPZ vaccines comprising Plasmodium falciparum (Pf) sporozoites (SPZ) have demonstrated > 90% protection against variant Pf malaria infections for at least 12 weeks; they are the only vaccines with the level of efficacy necessary to protect travellers. PfSPZ are eukaryotic cells stabilized by cryopreservation and distributed using a cryogenic (below -150°C) cold chain. The Ebola vaccine and mRNA vaccines against SARS-CoV-2 pioneered uptake of vaccines requiring non-standard ultra-low temperature cold chains...
January 11, 2024: Journal of Travel Medicine
https://read.qxmd.com/read/38203067/detection-and-control-framework-for-unpiloted-ground-support-equipment-within-the-aircraft-stand
#26
JOURNAL ARTICLE
Tianxiong Zhang, Zhiqiang Zhang, Xinping Zhu
The rapid advancement in Unpiloted Robotic Vehicle technology has significantly influenced ground support operations at airports, marking a critical shift towards future development. This study presents a novel Unpiloted Ground Support Equipment (GSE) detection and control framework, comprising virtual channel delineation, boundary line detection, object detection, and navigation and docking control, to facilitate automated aircraft docking within the aircraft stand. Firstly, we developed a bespoke virtual channel layout for Unpiloted GSE, aligning with operational regulations and accommodating a wide spectrum of aircraft types...
December 29, 2023: Sensors
https://read.qxmd.com/read/38198626/surgical-delay-of-thoracodorsal-artery-perforator-flaps-for-total-autologous-breast-reconstruction
#27
JOURNAL ARTICLE
Mark A Maier, Ryan D Hoffman, Anthony M Kordahi, Joshua Levine, Hugo St Hilaire, Robert J Allen
BACKGROUND: When abdomen-based free flap reconstruction is contraindicated, the muscle-sparing thoracodorsal artery perforator (TDAP) flap may be considered for total autologous breast reconstruction. The TDAP flap is often limited by volume and is prone to distal flap necrosis. We aim to demonstrate our experience combining the delay phenomenon with TDAP flaps for total autologous breast reconstruction. METHODS: Patients presenting for autologous breast reconstruction between April 2021 and August 2023 were recruited for surgically delayed TDAP flap reconstruction when abdominally based free flap reconstruction was contraindicated because of previous abdominal surgery or poor perforator anatomy...
February 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38157233/digital-phenotyping-for-mood-disorders-methodology-oriented-pilot-feasibility-study
#28
JOURNAL ARTICLE
Scott Breitinger, Manuel Gardea-Resendez, Carsten Langholm, Ashley Xiong, Joseph Laivell, Cynthia Stoppel, Laura Harper, Rama Volety, Alex Walker, Ryan D'Mello, Andrew Jin Soo Byun, Peter Zandi, Fernando S Goes, Mark Frye, John Torous
BACKGROUND: In the burgeoning area of clinical digital phenotyping research, there is a dearth of literature that details methodology, including the key challenges and dilemmas in developing and implementing a successful architecture for technological infrastructure, patient engagement, longitudinal study participation, and successful reporting and analysis of diverse passive and active digital data streams. OBJECTIVE: This article provides a narrative rationale for our study design in the context of the current evidence base and best practices, with an emphasis on our initial lessons learned from the implementation challenges and successes of this digital phenotyping study...
December 29, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/38147633/statistical-analysis-of-radioactivity-lamprecht-uranium-mine-in-texas
#29
JOURNAL ARTICLE
Mark C Harvey, Nancy L Glenn Griesinger
The former Lamprecht uranium mine facility in Texas ceased operations well before the new millennium. However, decommissioning activities were never completed by the licensee. Consequently, a legal proceeding was authorized between state and licensee representatives. Meanwhile, state funds were used to hire an independent contractor to perform radiological surveys and assess the magnitude of residual radioactivity across the terrain at the site. The purpose of this study was to apply advanced spatial statistical methods to the survey data measured by contractors at the Lamprecht site to precisely predict remaining radioactive hotspot locations post soil remediation activities...
February 1, 2024: Health Physics
https://read.qxmd.com/read/38139265/control-of-ccr5-cell-surface-targeting-by-the-praf2-gatekeeper
#30
JOURNAL ARTICLE
Elisa Da Silva, Mark G H Scott, Hervé Enslen, Stefano Marullo
The cell-surface targeting of neo-synthesized G protein-coupled receptors (GPCRs) involves the recruitment of receptors into COPII vesicles budding at endoplasmic reticulum exit sites (ERESs). This process is regulated for some GPCRs by escort proteins, which facilitate their export, or by gatekeepers that retain the receptors in the ER. PRAF2, an ER-resident four trans- membrane domain protein with cytoplasmic extremities, operates as a gatekeeper for the GB1 protomer of the heterodimeric GABAB receptor, interacting with a tandem di-leucine/RXR retention motif in the carboxyterminal tail of GB1...
December 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38123998/protein-biomarkers-and-alternatively-methylated-cell-free-dna-detect-early-stage-pancreatic-cancer
#31
JOURNAL ARTICLE
Roni Ben-Ami, Qiao-Li Wang, Jinming Zhang, Julianna G Supplee, Johannes F Fahrmann, Roni Lehmann-Werman, Lauren K Brais, Jonathan Nowak, Chen Yuan, Maureen Loftus, Ana Babic, Ehsan Irajizad, Tal Davidi, Aviad Zick, Ayala Hubert, Daniel Neiman, Sheina Piyanzin, Ofer Gal-Rosenberg, Amit Horn, Ruth Shemer, Benjamin Glaser, Natalia Boos, Kunal Jajoo, Linda Lee, Thomas E Clancy, Douglas A Rubinson, Kimmie Ng, John A Chabot, Fay Kastrinos, Michael Kluger, Andrew J Aguirre, Pasi A Jänne, Nabeel Bardeesy, Ben Stanger, Mark H O'Hara, Jacob Till, Anirban Maitra, Erica L Carpenter, Andrea J Bullock, Jeanine Genkinger, Samir M Hanash, Cloud P Paweletz, Yuval Dor, Brian M Wolpin
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when curative treatments can be employed. DESIGN: To assess circulating marker discrimination in training, testing and validation patient cohorts (total n=426 patients), plasma markers were measured among PDAC cases and patients with chronic pancreatitis, colorectal cancer (CRC), and healthy controls...
December 13, 2023: Gut
https://read.qxmd.com/read/38091606/plasma-growth-hormone-pulses-induce-male-biased-pulsatile-chromatin-opening-and-epigenetic-regulation-in-adult-mouse-liver
#32
JOURNAL ARTICLE
Andy Rampersaud, Jeannette Connerney, David J Waxman
Sex differences in plasma growth hormone (GH) profiles, pulsatile in males and persistent in females, regulate sex differences in hepatic STAT5 activation linked to sex differences in gene expression and liver disease susceptibility, but little is understood about the fundamental underlying, GH pattern-dependent regulatory mechanisms. Here, DNase-I hypersensitivity site (DHS) analysis of liver chromatin accessibility in a cohort of 18 individual male mice established that the endogenous male rhythm of plasma GH pulse-stimulated liver STAT5 activation induces dynamic, repeated cycles of chromatin opening and closing at several thousand liver DHS and comprises a novel mechanism conferring male bias to liver chromatin accessibility...
December 13, 2023: ELife
https://read.qxmd.com/read/38084658/evaluating-flow-distribution-in-a-multiaquifer-recharge-well-using-an-in-situ-flowmeter
#33
JOURNAL ARTICLE
Meredith B Martinez, Mark A Widdowson
Quantifying the flow rate distribution in a multiple-screen recharge well is relevant to understanding groundwater flow and solute transport behavior in managed aquifer recharge (MAR) operations. In this study, an impeller flowmeter was deployed to measure flow rate distribution in a multiple-screen MAR well under both recharge and pumping conditions screened in the multiple-strata of the Virginia Coastal Plain aquifer system. Preferential flow distribution in the well was observed through the uppermost screens during recharge while flow distribution was more evenly distributed along all screens under pumping conditions...
December 12, 2023: Ground Water
https://read.qxmd.com/read/38082806/individualized-ultrasound-guided-intervention-phantom-development-fabrication-and-proof-of-concept
#34
JOURNAL ARTICLE
Theodore T Pierce, Mark P Ottensmeyer, Avik Som, Laura J Brattain, Joshua S Werblin, Patrick D Sutphin, Scott Schoen, Matthew R Johnson, Lars Gjesteby, Brian A Telfer, Anthony E Samir
Commercial ultrasound vascular phantoms lack the anatomic diversity required for robust pre-clinical interventional device testing. We fabricated individualized phantoms to test an artificial intelligence enabled ultrasound-guided surgical robotic system (AI-GUIDE) which allows novices to cannulate deep vessels. After segmenting vessels on computed tomography scans, vessel cores, bony anatomy, and a mold tailored to the skin contour were 3D-printed. Vessel cores were coated in silicone, surrounded in tissue-mimicking gel tailored for ultrasound and needle insertion, and dissolved with water...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38082764/cervical-vagus-nerve-stimulation-disrupts-gastric-slow-wave-activity-in-rats
#35
JOURNAL ARTICLE
Omkar N Athavale, Leo K Cheng, Recep Avci, Alys R Clark, Peng Du
Cervical vagus nerve stimulation (cVNS) is a promising neuromodulation therapy for treating symptoms of disease in peripheral organs. The rat is a common animal model for studying and trialing new applications of cVNS therapy, but the stomach and its activity in rats is less well characterized than other animals, such as pigs. We sought to investigate the effects of acute, in vivo cVNS on gastric bioelectrical activity as an intermediate step to computational modeling of the effects of cVNS on gastric smooth muscle electromechanical coupling...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38058404/patterns-of-failure-for-recurrent-head-and-neck-squamous-cell-carcinoma-treated-with-salvage-surgery-and-postoperative-imrt-reirradiation
#36
JOURNAL ARTICLE
Abdallah S R Mohamed, Geoffrey V Martin, Sweet Ping Ng, Vinita Takiar, Beth M Beadle, Mark Zafereo, Adam S Garden, Steven J Frank, C David Fuller, G Brandon Gunn, William H Morrison, David I Rosenthal, Jay Reddy, Amy Moreno, Anna Lee, Jack Phan
PURPOSE/OBJECTIVES: The purpose of this study was to evaluate patterns of locoregional recurrence (LRR) after surgical salvage and adjuvant reirradiation with IMRT for recurrent head and neck squamous cell cancer (HNSCC). MATERIALS/METHODS: Patterns of LRR for 61 patients treated consecutively between 2003 and 2014 who received post-operative IMRT reirradiation to ≥ 60 Gy for recurrent HNSCC were determined by 2 methods: 1) physician classification via visual comparison of post-radiotherapy imaging to reirradiation plans; and 2) using deformable image registration (DIR)...
January 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38049147/isothermal-amplification-based-detection-of-single-base-rna-n6-methyladenosine
#37
JOURNAL ARTICLE
Ke Zhong, You Wu, Jiangli Zhou, Xianyuan Yang, Cheng Yi, Lichen Ge, Zigang Li, Weiling He, Jie Cao, Guanmin Jiang, Hongsheng Wang, Jiexin Li
N6-methyladenosine (m6 A) has recently gained much attention due to its diverse biological functions. Currently, the commonly used detection methods for locus-specific m6 A marks are complicated to operate, it is difficult to quantify the methylation level, and they have high false-positive levels. Here, we report a new method for locus-specific m6 A detection based on the methylate-sensitive endonuclease activity of MazF and the simultaneous amplification and testing (SAT) method, termed "m6 A-MazF-SAT". Mechanically, MazF fails to cleave the A (m6 A) CA motif; therefore, the undigested template can be SAT-amplified using specific probes targeting the upstream and downstream of sites of interest...
December 4, 2023: Analytical Chemistry
https://read.qxmd.com/read/38025690/zooplankton-biodiversity-and-temporal-dynamics-2005-2015-in-a-coastal-station-in-western-portugal-northeastern-atlantic-ocean
#38
JOURNAL ARTICLE
Antonina Dos Santos, Raquel Marques, Rita F T Pires
Long-term monitoring of zooplankton assemblages provides essential knowledge to assess key factors impacting marine ecosystems. Despite the importance of this type of data, monitoring stations worldwide are spatially and temporally limited due to the difficulty of maintaining them. In the northeastern Atlantic area, Cascais-Watch is one monitoring site operating since 2005, despite some constraints throughout the years, and has allowed the collection of important data on the zooplankton communities of the area...
2023: PeerJ
https://read.qxmd.com/read/38025608/osteocutaneous-radial-forearm-flap-harvest-technique-and-prophylactic-volar-locked-plating
#39
JOURNAL ARTICLE
Anthony E Capito, Brian K Hansen, Mark W Schmitt, Jadon H Beck, Brian A Cripe, Peter J Apel
BACKGROUND: The osteocutaneous radial forearm (OCRF) flap is a variation of the traditional radial forearm flap with incorporation of an anterolateral segment of corticocancellous bone of the radius, periosteum, and overlying skin. The OCRF flap is indicated in traumatic injuries or extirpation defects with segmental bone loss and is well suited to foot and ankle reconstruction due to its thin pliable skin. METHODS: In this single-center case series, a retrospective review was conducted to identify patients who underwent OCRF free flap for foot and ankle reconstruction that required harvest of more than 50% of the cross-sectional area of the radius with prophylactic volar locked plating of the donor site...
November 2023: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38020602/use-of-magnetic-source-imaging-to-assess-recovery-after-severe-traumatic-brain-injury-an-meg-pilot-study
#40
JOURNAL ARTICLE
Anand Karthik Sarma, Gautam Popli, Anthony Anzalone, Nicholas Contillo, Cassandra Cornell, Andrew M Nunn, Jared A Rowland, Dwayne W Godwin, Laura A Flashman, Daniel Couture, Jennifer R Stapleton-Kotloski
RATIONALE: Severe TBI (sTBI) is a devastating neurological injury that comprises a significant global trauma burden. Early comprehensive neurocritical care and rehabilitation improve outcomes for such patients, although better diagnostic and prognostic tools are necessary to guide personalized treatment plans. METHODS: In this study, we explored the feasibility of conducting resting state magnetoencephalography (MEG) in a case series of sTBI patients acutely after injury (~7 days), and then about 1...
2023: Frontiers in Neurology
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