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https://www.readbyqxmd.com/read/29224246/circadian-peak-dopaminergic-activity-response-at-the-biological-clock-pacemaker-suprachiasmatic-nucleus-area-mediates-the-metabolic-responsiveness-to-a-high-fat-diet
#1
Shuqin Luo, Yahong Zhang, Michael Ezrokhi, Yang Li, Tsung-Huang Tsai, Anthony H Cincotta
Among vertebrate species of the major vertebrate classes in the wild, a seasonal rhythm of whole body fuel metabolism, oscillating from lean to obese condition, is a common biological phenomenon. This annual cycle is driven in part by annual changes in the circadian dopaminergic signaling at the suprachiasmatic nuclei (SCN), with diminution of circadian peak dopaminergic activity at the SCN facilitating development of the seasonal obese insulin resistant condition. The present study investigated whether such an ancient circadian dopamine-SCN activity system for expression of the seasonal obese, insulin resistant phenotype may be operative in animals made obese, insulin resistant by high fat feeding and if so whether reinstatement of the circadian dopaminergic peak at the SCN would be sufficient to reverse the adverse metabolic impact of the high fat diet without alteration of caloric intake...
December 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29219403/quantum-critical-behavior-of-one-dimensional-soft-bosons-in-the-continuum
#2
Stefano Rossotti, Martina Teruzzi, Davide Pini, Davide Emilio Galli, Gianluca Bertaina
We consider a zero-temperature one-dimensional system of bosons interacting via the soft-shoulder potential in the continuum, typical of dressed Rydberg gases. We employ quantum Monte Carlo simulations, which allow for the exact calculation of imaginary-time correlations, and a stochastic analytic continuation method, to extract the dynamical structure factor. At finite densities, in the weakly interacting homogeneous regime, a rotonic spectrum marks the tendency to clustering. With strong interactions, we indeed observe cluster liquid phases emerging, characterized by the spectrum of a composite harmonic chain...
November 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29207475/function-of-micrornas-in-the-osteogenic-differentiation-and-therapeutic-application-of-adipose-derived-stem-cells-ascs
#3
REVIEW
Walter M Hodges, Frederick O'Brien, Sadanand Fulzele, Mark W Hamrick
Traumatic wounds with segmental bone defects represent substantial reconstructive challenges. Autologous bone grafting is considered the gold standard for surgical treatment in many cases, but donor site morbidity and associated post-operative complications remain a concern. Advances in regenerative techniques utilizing mesenchymal stem cell populations from bone and adipose tissue have opened the door to improving bone repair in the limbs, spine, and craniofacial skeleton. The widespread availability, ease of extraction, and lack of immunogenicity have made adipose-derived stem cells (ASCs) particularly attractive as a stem cell source for regenerative strategies...
December 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29198786/the-integrated-contaminant-elution-and-tracer-test-toolkit-icet3-for-improved-characterization-of-mass-transfer-attenuation-and-mass-removal
#4
Mark L Brusseau, Zhilin Guo
It is evident based on historical data that groundwater contaminant plumes persist at many sites, requiring costly long-term management. High-resolution site-characterization methods are needed to support accurate risk assessments and to select, design, and operate effective remediation operations. Most subsurface characterization methods are generally limited in their ability to provide unambiguous, real-time delineation of specific processes affecting mass-transfer, transformation, and mass removal, and accurate estimation of associated rates...
November 23, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29195912/procedure-specific-trends-in-surgical-outcomes
#5
Jason B Liu, Julia R Berian, Yaoming Liu, Mark E Cohen, Clifford Y Ko, Bruce L Hall
BACKGROUND: Quality improvement efforts have generally focused on hospital benchmarking, and processes and outcomes shared among all operations. However, quality improvement could be inconsistent across different types of operations. The objective of this study was to identify operations needing additional concerted quality improvement efforts by examining their outcomes trends. STUDY DESIGN: Ten procedures (colectomy, esophagectomy, hepatectomy, hysterectomy, pancreatectomy, proctectomy, total hip arthroplasty, total knee arthroplasty, thyroidectomy, and ventral hernia repair) commonly accrued into the American College of Surgeons NSQIP between 2008 and 2015 were included...
November 7, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29194906/radical-gastric-cancer-surgery-results-in-widespread-upregulation-of-pro-tumourigenic-intraperitoneal-cytokines
#6
Andrew J Long, Paul R Burton, Michael J De Veer, Geraldine J Ooi, Cheryl P Laurie, Peter D Nottle, Matthew J Watt, Wendy A Brown
BACKGROUND: Radical surgical resection is the mainstay of curative treatment for oesophagogastric malignancy. However, survival and recurrence rates remain poor. Theoretical data suggests that the inflammatory response to surgery can promote tumour recurrence. The local and systemic inflammatory response to radical oesophagogastric cancer surgery has not been fully characterized. We aimed to measure this response, particularly factors associated with tumour implantation. METHODS: Consecutive patients undergoing radical junctional or gastric cancer resection over 12 months were recruited...
November 30, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29186712/reproductive-hormones-and-their-receptors-may-affect-lung-cancer
#7
Mengmeng Dou, Keyan Zhu, Zhirui Fan, Yuxuan Zhang, Xiufang Chen, Xueliang Zhou, Xianfei Ding, Lifeng Li, Zhaosen Gu, Maofeng Guo, Ming Yan, Xiaoming Deng, Peihong Shen, Shuling Wang
BACKGROUND/AIMS: In contrast to men, women have experienced a rapid increase in lung cancer mortality. Numerous studies have found that the sex differences in lung cancer are due to reproductive hormones. Experiments in female mice with and without ovariectomy were performed to explore the possible mechanism by which sex hormones (and their receptors) influence lung cancer. METHODS: Twenty-four female C57BL/6 mice aged 56-62 days were randomly divided into the ovariectomized group and the control group...
November 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29183925/cohort-profile-the-truenth-global-registry-an-international-registry-to-monitor-and-improve-localised-prostate-cancer-health-outcomes
#8
Sue M Evans, Jeremy L Millar, Caroline M Moore, John D Lewis, Hartwig Huland, Fanny Sampurno, Sarah E Connor, Paul Villanti, Mark S Litwin
PURPOSE: Globally, prostate cancer treatment and outcomes for men vary according to where they live, their race and the care they receive. The TrueNTH Global Registry project was established as an international registry monitoring care provided to men with localised prostate cancer (CaP). PARTICIPANTS: Sites with existing CaP databases in Movember fundraising countries were invited to participate in the international registry. In total, 25 Local Data Centres (LDCs) representing 113 participating sites across 13 countries have nominated to contribute to the project...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29174848/-back-loss-cover-in-orthopedic-surgery-by-helical-lumbar-perforator-flaps-about-6-cases
#9
L Ruffenach, E Robert, C Dissaux, C Bruant-Rodier, F Bodin
INTRODUCTION: The existence of voluminous paralumbar perforators allows a simplification of the coverage of the lumbar region. MATERIALS AND METHODS: The authors present a series about lumbar loss substance following orthopedic surgery, from 2012 to 2017. Coverage was provided by a fascio-cutaneous lumbar perforator flap. RESULTS: Six patients were operated with mean age of 62.3 years, with an average follow-up of 16 months (up 6 to 41 months)...
November 23, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29174717/comparison-of-cytof-assays-across-sites-results-of-a-six-center-pilot-study
#10
Michael D Leipold, Gerlinde Obermoser, Craig Fenwick, Katja Kleinstuber, Narges Rashidi, John P McNevin, Allison N Nau, Lisa E Wagar, Virginie Rozot, Mark M Davis, Stephen DeRosa, Giuseppe Pantaleo, Thomas J Scriba, Bruce D Walker, Lars R Olsen, Holden T Maecker
For more than five years, high-dimensional mass cytometry has been employed to study immunology. However, these studies have typically been performed in one laboratory on one or few instruments. We present the results of a six-center study using healthy control human peripheral blood mononuclear cells (PBMCs) and commercially available reagents to test the intra-site and inter-site variation of mass cytometers and operators. We used prestained controls generated by the primary center as a reference to compare against samples stained at each individual center...
November 22, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29166785/elevated-radiation-exposure-associated-with-above-surface-flat-detector-mini-c-arm-use
#11
Dennis P Martin, Talia Chapman, Christopher Williamson, Brian Tinsley, Asif M Ilyas, Mark L Wang
BACKGROUND: This study aims to test the hypothesis that: (1) radiation exposure is increased with the intended use of Flat Surface Image Intensifier (FSII) units above the operative surface compared with the traditional below-table configuration; (2) this differential increases in a dose-dependent manner; and (3) radiation exposure varies with body part and proximity to the radiation source. METHODS: A surgeon mannequin was seated at a radiolucent hand table, positioned for volar distal radius plating...
November 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29164625/mechanisms-and-mitochondrial-redox-signaling-in-photobiomodulation
#12
Michael R Hamblin
Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria, and more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO thus restoring electron transport and increasing mitochondrial membrane potential...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29141868/geographic-clonal-tracking-in-macaques-provides-insights-into-hspc-migration-and-differentiation
#13
Chuanfeng Wu, Diego A Espinoza, Samson J Koelle, E Lake Potter, Rong Lu, Brian Li, Di Yang, Xing Fan, Robert E Donahue, Mario Roederer, Cynthia E Dunbar
The geographic distribution of hematopoiesis at a clonal level is of interest in understanding how hematopoietic stem and progenitor cells (HSPCs) and their progeny interact with bone marrow (BM) niches during regeneration. We tagged rhesus macaque autologous HSPCs with genetic barcodes, allowing clonal tracking over time and space after transplantation. We found marked geographic segregation of CD34(+) HSPCs for at least 6 mo posttransplantation, followed by very gradual clonal mixing at different BM sites over subsequent months to years...
November 15, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29135883/an-analysis-of-the-incidence-and-outcomes-of-major-vs-minor-neurological-decline-after-complex-adult-spinal-deformity-surgery-a-sub-analysis-of-scoli-risk-1-study
#14
So Kato, Michael G Fehlings, Stephen J Lewis, Lawrence G Lenke, Christopher I Shaffrey, Kenneth M C Cheung, Leah Carreon, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Khaled M Kebaish, Christopher P Ames, Yong Qiu, Yukihiro Matsuyama, Benny T Dahl, Hossein Mehdian, Ferran Pellisé, Sigurd H Berven
STUDY DESIGN: A sub-analysis from a prospective, multicenter, international cohort study in 15 sites (Scoli-RISK-1). OBJECTIVE: To report detailed information regarding the severity of neurological decline related to complex adult spine deformity (ASD) surgery and to examine outcomes based on severity. SUMMARY OF BACKGROUND DATA: The basis of post-operative neurological decline after ASD surgeries can occur due to nerve root(s) or spinal cord dysfunction...
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29134168/anatomical-region-segmentation-for-objective-surgical-skill-assessment-with-operating-room-motion-data
#15
Yangming Li, Randall A Bly, R Alex Harbison, Ian M Humphreys, Mark E Whipple, Blake Hannaford, Kris S Moe
Background  Most existing objective surgical motion analysis schemes are limited to structured surgical tasks or recognition of motion patterns for certain categories of surgeries. Analyzing instrument motion data with respect to anatomical structures can break the limit, and an anatomical region segmentation algorithm is required for the analysis. Methods  An atlas was generated by manually segmenting the skull base into nine regions, including left/right anterior/posterior ethmoid sinuses, frontal sinus, left and right maxillary sinuses, nasal airway, and sphenoid sinus...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29124706/role-of-ultraviolet-disinfection-in-the-prevention-of-surgical-site-infections
#16
Sarah Simmons, Charles Dale, James Holt, Katie Velasquez, Mark Stibich
The role of the environment in surgical site infections is surprisingly understudied. UV disinfection holds promise for reducing the level of contamination in operating rooms and thereby lowering the risk of infection for patients. Issues such as the frequency, amount and locations for UV disinfection to have an impact on the risk of surgical site infection are recently emerging in the literature. As technologies and knowledge improve, UV disinfection will have a role to play in operating rooms in the future...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29109059/loop-f-of-the-gabaa-receptor-alpha-subunit-governs-gaba-potency
#17
Adrienn Pálvölgyi, Krisztina Móricz, Ágnes Pataki, Balázs Mihalik, Gábor Gigler, Katalin Megyeri, Szabolcs Udvari, István Gacsályi, Ferenc A Antoni
Gamma-amino butyric acid (GABA) is an abundant neurotransmitter in the CNS. GABAergic interneurons orchestrate pyramidal neurons in the cerebral cortex, and thus control learning and memory. Ionotropic receptors for GABA (GABAAR) are heteropentameric complexes of α, β and γ integral membrane-protein subunits forming Cl(-) -channels operated by GABA, which are vital for brain function and are important drug targets. However, knowledge on how GABAAR bind GABA is controversial. Structural biology versus functional modelling combined with site-directed mutagenesis suggest markedly different roles for loop F of the extracellular domain of the α-subunit when complexed with GABA...
November 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29101908/using-drone-mounted-cameras-for-on-site-body-documentation-3d-mapping-and-active-survey
#18
Petra Urbanová, Mikoláš Jurda, Tomáš Vojtíšek, Jan Krajsa
Recent advances in unmanned aerial technology have substantially lowered the cost associated with aerial imagery. As a result, forensic practitioners are today presented with easy low-cost access to aerial photographs at remote locations. The present paper aims to explore boundaries in which the low-end drone technology can operate as professional crime scene equipment, and to test the prospects of aerial 3D modeling in the forensic context. The study was based on recent forensic cases of falls from height admitted for postmortem examinations...
October 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29089281/influence-of-biologic-subtype-of-inflammatory-breast-cancer-on-response-to-neoadjuvant-therapy-and-cancer-outcomes
#19
Tina J Hieken, Brittany L Murphy, Judy C Boughey, Amy C Degnim, Katrina N Glazebrook, Tanya L Hoskin
BACKGROUND: Few data exist on the influence of tumor biologic subtype on treatment response and outcomes for inflammatory breast cancer (IBC). We examined a contemporary cohort of IBC patients treated with current targeted systemic therapies, selected on the basis of tumor biologic subtype, to evaluate pathologic treatment response and cancer outcomes across biologic subtypes. PATIENTS AND METHODS: We studied 57 clinical stage T4dM0 IBC patients operated on at our institution from October 2008 to July 2015...
October 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29081268/transitioning-from-a-single-site-pilot-project-to-a-state-wide-regional-telehealth-service-the-experience-from-the-victorian-stroke-telemedicine-programme
#20
Kathleen L Bagot, Dominique A Cadilhac, Joosup Kim, Michelle Vu, Mark Savage, Les Bolitho, Glenn Howlett, Justin Rabl, Helen M Dewey, Peter J Hand, Sonia Denisenko, Geoffrey A Donnan, Christopher F Bladin
Scaling of projects from inception to establishment within the healthcare system is rarely formally reported. The Victorian Stroke Telemedicine (VST) programme provided a very useful opportunity to describe how rural hospitals in Victoria were able to access a network of Melbourne-based neurologists via telemedicine. The VST programme was initially piloted at one site in 2010 and has gradually expanded as a state-wide regional service operating with 16 hospitals in 2017. The aim of this paper is to summarise the factors that facilitated the state-wide transition of the VST programme...
December 2017: Journal of Telemedicine and Telecare
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