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https://www.readbyqxmd.com/read/28532856/implementation-of-a-referral-to-discharge-glycemic-control-initiative-for-reduction-of-surgical-site-infections-in-gynecologic-oncology-patients
#1
Laura Hopkins, Jennifer Brown-Broderick, James Hearn, Janine Malcolm, James Chan, Wendy Hicks-Boucher, Filomena De Sousa, Mark C Walker, Sylvain Gagné
OBJECTIVE(S): To evaluate the frequency of surgical site infections before and after implementation of a comprehensive, multidisciplinary perioperative glycemic control initiative. STUDY METHODS: As part of a CUSP (Comprehensive Unit-based Safety Program) initiative, between January 5 and December 18, 2015, we implemented comprehensive, multidisciplinary glycemic control initiative to reduce SSI rates in patients undergoing major pelvic surgery for a gynecologic malignancy ('Group II')...
May 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28529358/how-do-psychiatrists-in-india-construct-their-professional-identity-a-critical-literature-review
#2
Clement Bayetti, Sushrut Jadhav, Smita N Deshpande
Psychiatric practice in India is marked by an increasing gulf between largely urban-based mental health professionals and a majority rural population. Based on the premise that any engagement is a mutually constructed humane process, an understanding of the culture of psychiatry including social process of local knowledge acquisition by trainee psychiatrists is critical. This paper reviews existing literature on training of psychiatrists in India, the cultural construction of their professional identities and autobiographical reflections...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28523361/can-laparoscopic-surgery-prevent-incisional-hernia-in-patients-with-crohn-s-disease-a-comparison-study-of-750-patients-undergoing-open-and-laparoscopic-bowel-resection
#3
Tomas M Heimann, Santosh Swaminathan, Adrian J Greenstein, Alexander J Greenstein, Sergey Khaitov, Randolph M Steinhagen, Barry A Salky
BACKGROUND: Incisional hernia (IH) is a frequent occurrence following open surgery for Crohn's disease (CD). This study compares the IH rates of patients with CD undergoing open versus laparoscopic bowel resection. METHODS: Seven hundred and fifty patients with CD operated by the authors at the Mount Sinai Medical Center, New York, USA, were reviewed from a prospectively maintained surgical database. Five hundred patients with Crohn's disease undergoing open surgery were compared to 250 patients undergoing laparoscopic bowel resection...
May 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28521445/low-expression-levels-of-insulin-like-growth-factor-binding-protein-3-are-correlated-with-poor-prognosis-for-patients-with-hepatocellular-carcinoma
#4
Jinjin Yan, Xinzheng Yang, Lin Li, Pengtao Liu, Honghui Wu, Zhanao Liu, Qingyi Li, Guozhen Liao, Xinlong Wang
Insulin-like growth factor binding protein-3 (IGFBP-3) has previously been identified as a putative tumor suppressor gene. The present study investigated the clinical and prognostic significance of IGFBP-3 expression levels in patients with hepatocellular carcinoma (HCC). Immunohistochemistry (IHC) probing for IGFBP-3 was performed on paraffin-embedded tissue samples obtained from 120 patients with HCC, including tissue samples from 120 primary cancer sites and 50 matched adjacent non-malignant sites. Receiver-operator curve (ROC) analysis was used to determine the cut-off scores for the presence of IGFBP-3-positive tumor cells and to estimate the survival time of the patients...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28493599/spinal-cord-stimulator-implant-infection-rates-and-risk-factors-a-multicenter-retrospective-study
#5
Bryan C Hoelzer, Mark A Bendel, Timothy R Deer, Jason S Eldrige, David R Walega, Zhen Wang, Shrif Costandi, Gerges Azer, Wenchun Qu, Steven M Falowski, Stephanie A Neuman, Susan M Moeschler, Catherine Wassef, Christopher Kim, Tariq Niazi, Taher Saifullah, Brian Yee, Chong Kim, Christine L Oryhan, Joshua M Rosenow, Daniel T Warren, Imanuel Lerman, Ruben Mora, Salim M Hayek, Michael Hanes, Thomas Simopoulos, Sanjiv Sharma, Chris Gilligan, Warren Grace, Timothy Ade, Nagy A Mekhail, John P Hunter, Daniel Choi, Deborah Y Choi
OBJECTIVES: Spinal cord stimulation is an evidence-based treatment for a number of chronic pain conditions. While this therapy offers improvement in pain and function it is not without potential complications. These complications include device failure, migration, loss of therapeutic paresthesia, and infection. This article looked to establish a modern infection rate for spinal cord stimulators, assess the impact of known risk factors for surgical site infections and to determine the impact of certain preventative measures on the rate of infection...
May 11, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28483635/crystal-structure-of-tissue-factor-in-complex-with-antibody-10h10-reveals-the-signaling-epitope
#6
Alexey Teplyakov, Galina Obmolova, Thomas J Malia, Bingyuan Wu, Yonghong Zhao, Susann Taudte, G Mark Anderson, Gary L Gilliland
Tissue factor (TF) initiates the extrinsic pathway of blood coagulation through sequential binding and activation of coagulation factors VII (FVII) and X (FX). In addition, through activation of G-protein-coupled protease activated receptors (PARs) TF induces cell signaling that is related to cancer, angiogenesis and inflammation. Monoclonal antibodies (mAbs) proved to be a useful tool for studying the interplay between TF signaling and coagulation. MAb 10H10 is unique in that it blocks the signaling pathway and thus inhibits angiogenesis and tumor growth without interfering with coagulation...
May 5, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28476440/efficacy-and-safety-of-subcutaneous-rituximab-versus-intravenous-rituximab-for-first-line-treatment-of-follicular-lymphoma-sabrina-a-randomised-open-label-phase-3-trial
#7
Andrew Davies, Francesco Merli, Biljana Mihaljević, Santiago Mercadal, Noppadol Siritanaratkul, Philippe Solal-Céligny, Axel Boehnke, Claude Berge, Magali Genevray, Artem Zharkov, Mark Dixon, Michael Brewster, Martin Barrett, David MacDonald
BACKGROUND: Intravenous rituximab is the standard of care in B-cell non-Hodgkin lymphoma, and is administered over 1·5-6 h. A subcutaneous formulation could reduce patients' treatment burden and improve resource utilisation in health care. We aimed to show the pharmacokinetic non-inferiority of subcutaneous rituximab to intravenous rituximab in follicular lymphoma and to provide efficacy and safety data. METHODS: SABRINA is a two-stage, randomised, open-label phase 3 study at 113 centres in 30 countries...
May 2, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28462011/comparison-of-two-detailed-models-of-aedes-aegypti-population-dynamics
#8
Mathieu Legros, Marcelo Otero, Victoria Romeo Aznar, Hernan Solari, Fred Gould, Alun L Lloyd
The success of control programs for mosquito borne diseases can be enhanced by crucial information provided by models of the mosquito populations. Models, however, can differ in their structure, complexity and biological assumptions, and these differences impact their predictions. Unfortunately, it is typically difficult to determine why two complex models make different predictions because we lack structured side-by-side comparisons of models using comparable parameterization. Here we present a detailed comparison of two complex, spatially-explicit, stochastic models of the population dynamics of Aedes aegypti, the main vector of dengue, yellow fever, chikungunya and Zika viruses...
October 2016: Ecosphere
https://www.readbyqxmd.com/read/28455286/ultrasound-biomicroscopy-validation-of-a-murine-model-of-cardiac-hypertrophic-preconditioning-comparison-with-a-hemodynamic-assessment
#9
Jiayuan Huang, Jian Wu, Shijun Wang, Jieyun You, Yong Ye, Zhiwen Ding, Fenghua Yang, Xingxu Wang, Junjie Guo, Leilei Ma, Jie Yuan, Yunli Shen, Xiangdong Yang, Aijun Sun, Hong Jiang, Liping Bu, Peter H Backx, Junbo Ge, Yunzeng Zou
In mice, myocardial hypertrophic preconditioning (HP), which is produced by the removal of short-term transverse aortic constriction (TAC), was recently reported to render the heart resistant to hypertrophic responses induced by subsequent re-constriction (Re-TAC). However, there is no efficient non-invasive method for ensuring that the repeated aortic manipulations were successfully performed. We previously demonstrated that ultrasound biomicroscopy (UBM) is a non-invasive and effective approach for predicting TAC success...
April 28, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28453343/acute-isolated-flexor-tendon-laceration-associated-with-a-distal-radius-fracture
#10
J Ryan Hill, Ram K Alluri, Alidad Ghiassi
BACKGROUND: Subacute rupture of the flexor tendons secondary to distal radius fractures is well documented. Recently, accounts of flexor tendon rupture following open reduction internal fixation have been associated with volar plate fixation. However, discovery of an occult traumatic flexor tendon laceration during fixation of an acute distal radius fracture is not well described. This case indicates the importance of careful preoperative and intraoperative examination of the flexor tendons in the setting of comminuted distal radius fractures...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28435283/unlocking-the-black-box-of-practice-improvement-strategies-to-implement-surgical-safety-checklists-a-process-evaluation
#11
Brigid M Gillespie, Kyra Hamilton, Dianne Ball, Joanne Lavin, Therese Gardiner, Teresa K Withers, Andrea P Marshall
BACKGROUND: Compliance with surgical safety checklists (SSCs) has been associated with improvements in clinical processes such as antibiotic use, correct site marking, and overall safety processes. Yet, proper execution has been difficult to achieve. OBJECTIVES: The objective of this study was to undertake a process evaluation of four knowledge translation (KT) strategies used to implement the Pass the Baton (PTB) intervention which was designed to improve utilization of the SSC...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28424628/branchial-pathomorphology-of-southern-bluefin-tuna-thunnus-maccoyii-castelnau-1872-infected-by-helminth-and-copepodan-parasites
#12
Mark B Adams, Craig J Hayward, Barbara F Nowak
Three metazoan parasites, a monogenean Hexostoma thynni and two species of copepods Pseudocycnus appendiculatus and Euryphorus brachypterus are known to parasitize the gills of ranched southern bluefin tuna (SBT) and other tuna species. However, there is no detailed information describing the pathological response to infection by these parasites in this species. Wild southern bluefin tuna Thunnus maccoyii (approximately 3 years of age), captured and towed to a grow-out site in the waters immediately south of Port Lincoln, South Australia were subsequently sampled (n = 10) monthly from March until August 2004 during commercial harvest operations...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28422917/an-adapted-clavien-dindo-scoring-system-in-trauma-as-a-clinically-meaningful-non-mortality-endpoint
#13
David N Naumann, Laura E Vincent, Nicola Pearson, Alastair Beaven, Iain M Smith, Kieran Smith, Emma Toman, Helen R Dorrance, Keith Porter, Charles E Wade, Bryan A Cotton, John B Holcomb, Mark J Midwinter
BACKGROUND: There is no consensus on reporting non-mortality trauma complications in a graded manner. The Clavien-Dindo scale of complications was originally for elective surgery, and requires adaptation to provide meaningful data for trauma patients. In particular the original score does not account for those treated without surgery. We report an adapted Clavien-Dindo in trauma (ACDiT) scale and apply it to patients managed operatively and non-operatively. METHODS: A combined prospective and retrospective international multi-center observational study was undertaken to apply the ACDiT scale to 484 trauma patients at 3 university teaching hospitals (Birmingham, England (n=303); Houston, Texas (n=113); and Glasgow, Scotland (n=68))...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28422916/beware-of-the-interval-cholecystectomy
#14
James Ackerman, Ryan Abegglen, Mark Scaife, Andrew Peitzman, Matthew Rosengart, Wallis Marsh, Kurt Stahlfeld
BACKGROUND *: Despite limited data regarding the indications and effectiveness of percutaneous cholecystostomy (PC) in the treatment of acute cholecystitis (AC), usage has increased by over 500% since 1994. Many of these patients subsequently undergo interval cholecystectomy (IC), a procedure that has not been rigorously evaluated. This aim of this study was to quantify the morbidity and mortality associated with the IC. METHODS *: We included all consecutive adult patients (>18 years old) who underwent PC and IC from January 2008 to December 2013...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28420433/umbilical-cord-derived-mesenchymal-stem-cells-on-scaffolds-facilitate-collagen-degradation-via-upregulation-of-mmp-9-in-rat-uterine-scars
#15
Lu Xu, Lijun Ding, Lei Wang, Yun Cao, Hui Zhu, Jingjie Lu, Xin'an Li, Tianran Song, Yali Hu, Jianwu Dai
BACKGROUND: Severe injuries of the uterus may trigger uterine scar formation, ultimately leading to infertility or obstetrical complications. To date, few methods have adequately solved the problem of collagen deposition in uterine scars. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) have shown great promise in clinical applications. The objective of this study was to investigate the effect of a scaffold/UC-MSCs construct on collagen degradation and functional regeneration in rat uterine scars following full-thickness excision of uterine walls...
April 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28413653/a-novel-option-for-preoperative-endoscopic-marking-with-india-ink-in-totally-laparoscopic-distal-gastrectomy-for-gastric-cancer-a-useful-technique-considering-the-morphological-characteristics-of-the-stomach
#16
Takaya Tokuhara, Eiji Nakata, Toshiyuki Tenjo, Isao Kawai, Syunpei Satoi, Keisuke Inoue, Mariko Araki, Hirofumi Ueda, Chihiro Higashi
In totally laparoscopic distal gastrectomy (TLDG) for gastric cancer, accurately determining the proximal resection line may be difficult. This is because identifying the lesion intracorporeally is impossible, due to the lack of tactile sense, and, in addition, unlike the intestine, the most proximal site of the lesion is often different from the main site due to the distorted shape of the stomach. The aim of this study was to introduce a novel method of preoperative endoscopic marking with India ink, taking into consideration the morphological characteristics of the stomach...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28412973/genome-wide-dna-methylation-measurements-in-prostate-tissues-uncovers-novel-prostate-cancer-diagnostic-biomarkers-and-transcription-factor-binding-patterns
#17
Marie K Kirby, Ryne C Ramaker, Brian S Roberts, Brittany N Lasseigne, David S Gunther, Todd C Burwell, Nicholas S Davis, Zulfiqar G Gulzar, Devin M Absher, Sara J Cooper, James D Brooks, Richard M Myers
BACKGROUND: Current diagnostic tools for prostate cancer lack specificity and sensitivity for detecting very early lesions. DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids such as urine and blood plasma that could serve as a non-invasive diagnostic biomarker for prostate cancer. METHODS: We measured genome-wide DNA methylation patterns in 73 clinically annotated fresh-frozen prostate cancers and 63 benign-adjacent prostate tissues using the Illumina Infinium HumanMethylation450 BeadChip array...
April 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28409262/radioguided-occult-lesion-localization-for-locally-recurrent-thyroid-carcinoma
#18
Mehmet Ali Gulcelik, Niyazi Karaman, Lutfi Dogan, Ilgın Sahiner, Gokhan Giray Akgul, Yavuz Selim Kahraman, Gulin Ucmak Vural
The aim of this study was to present our experiences with patients operated on for the recurrence of papillary thyroid cancer with the combined use of preoperative ultrasonographic mapping and radioguided occult lesion localization (ROLL). Twenty patients who had already undergone total thyroidectomy and central/lateral neck dissection for papillary thyroid carcinoma were reoperated on due to locoregional metastasis. The patients with proven recurrences and high Tg wash-out levels in cytopathologic aspirates were operated on...
April 13, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28408327/morbidity-and-mortality-after-surgery-for-nonmalignant-colorectal-polyps
#19
Anne F Peery, Nicholas J Shaheen, Katherine S Cools, Todd H Baron, Mark Koruda, Joseph A Galanko, Ian S Grimm
BACKGROUND & AIMS: Despite evidence that most non-malignant colorectal polyps can be managed endoscopically, a substantial proportion of patients with a non-malignant colorectal polyp are still sent to surgery. Risks associated with this surgery are not well characterized. We aimed to describe 30-day post-operative morbidity and mortality and to explore risk factors for adverse events in patients undergoing surgical resection for non-malignant colorectal polyps. METHODS: We analyzed data collected prospectively as part of the National Surgical Quality Improvement Program...
April 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28405284/role-of-breeding-and-natal-movements-in-lifetime-dispersal-of-a-forest-dwelling-rodent
#20
Vesa Selonen, Ralf Wistbacka
The lifetime movements of an individual determine the gene flow and invasion potential of the species. However, sex dependence of dispersal and selective pressures driving dispersal have gained much more attention than dispersal at different life and age stages. Natal dispersal is more common than dispersal between breeding attempts, but breeding dispersal may be promoted by resource availability and competition. Here, we utilize mark-recapture data on the nest-box population of Siberian flying squirrels to analyze lifetime dispersal patterns...
April 2017: Ecology and Evolution
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