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https://www.readbyqxmd.com/read/29790425/hypoxic-preconditioning-reduces-propofol-induced-neuroapoptosis-via-regulation-of-bcl-2-and-bax-and-downregulation-of-activated-caspase-3-in-the-hippocampus-of-neonatal-rats
#1
Jing Lv, Yubing Liang, Youbing Tu, Jing Chen, Yubo Xie
OBJECTIVE:  Evidence has shown that propofol may cause widespread apoptotic neurodegeneration. Hypoxic preconditioning (HPC) was previously demonstrated to provide neuroprotection and brain recovery from either acute or chronic neurodegeneration in several cellular and animal models. Therefore, the present study was designed to investigate the protective effects of hypoxic preconditioning on apoptosis caused by propofol in neonatal rats. METHODS: Propofol (100 mg/kg) was given to 7-day-old (P7) Sprague Dawley pups...
May 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29786661/suspended-carbon-nanotubes-for-humidity-sensing
#2
Shivaram Arunachalam, Anubha A Gupta, Ricardo Izquierdo, Frederic Nabki
A room temperature microfabrication technique using SU8, an epoxy-based highly functional photoresist as a sacrificial layer, is developed to obtain suspended aligned carbon nanotube beams. The humidity-sensing characteristics of aligned suspended single-walled carbon nanotube films are studied. A comparative study between suspended and non-suspended architectures is done by recording the resistance change in the nanotubes under humidity. For the tests, the humidity was varied from 15% to 98% RH. A comparative study between suspended and non-suspended devices shows that the response and recovery times of the suspended devices was found to be almost 3 times shorter than the non-suspended devices...
May 22, 2018: Sensors
https://www.readbyqxmd.com/read/29784346/speciation-of-organic-inorganic-mercury-and-total-mercury-in-blood-samples-using-vortex-assisted-dispersive-liquid-liquid-microextraction-based-on-the-freezing-of-deep-eutectic-solvent-followed-by-gfaas
#3
Reza Akramipour, Mohammad Reza Golpayegani, Simin Gheini, Nazir Fattahi
In this research, a new vortex assisted dispersive liquid-liquid microextraction based on the freezing of deep eutectic solvent (VADLLME-FDES) has been developed for the determination of organic mercury (R-Hg) and inorganic mercury (Hg2+ ) in blood samples prior to their analysis by graphite furnace atomic absorption spectrometry (GFAAS). In this method, a green solvent consisting of 1-octyl-3-methylimidazolium chloride and 1-undecanol was used as an extraction solvent, yielding the advantages of material stability, low density, and a suitable freezing point near room temperature...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783184/postoperative-outcomes-in-patients-with-a-do-not-resuscitate-dnr-order-undergoing-elective-procedures
#4
Ethan Y Brovman, Elisa C Walsh, Brittany N Burton, Christine E Kuo, Charlotta Lindvall, Rodney A Gabriel, Richard D Urman
STUDY OBJECTIVE: Do-not-resuscitate (DNR) status has been shown to be an independent risk factor for mortality in the post-operative period. Patients with DNR orders often undergo elective surgeries to alleviate symptoms and improve quality of life, but there are limited data on outcomes for informed decision making. DESIGN: Retrospective cohort study. SETTING: A multi-institutional setting including operating room, postoperative recovery area, inpatient wards, and the intensive care unit...
May 18, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29778455/planning-post-discharge-destination-for-gastrointestinal-surgery-patients-room-for-improvement
#5
Courtney J Balentine, Kelly Kenzik, Daniel I Chu, Melanie S Morris, Sara J Knight, Cynthia J Brown, Smita Bhatia
BACKGROUND: We compared short-term recovery for patients discharged to inpatient rehabilitation versus skilled nursing facilities after gastrointestinal surgery. MATERIALS & METHODS: We conducted a propensity-matched cohort study of 12,939 adults discharged to inpatient rehabilitation or skilled nursing facilities after colectomy, pancreatectomy or hepatectomy at hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program from 2011 to 2014...
May 16, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29777884/neurosurgical-management-of-self-inflicted-cranial-crossbow-injury
#6
Charles G Kulwin, Andrew DeNardo, Saad Khairi, Troy Payner
BACKGROUND: While gun-related penetrating traumatic brain injuries make up the majority of cranial missile injuries, low-velocity penetrating injuries present significant clinical difficulties that cannot necessarily be identically managed. Bow hunting is an increasingly popular pastime, and a crossbow allows a unique mechanism to cause a self-inflicted cranial injury with a large, low-velocity projectile. Historically, arrow removal is described in an operating room setting, which provides limited knowledge of the location of vascular injury in the setting of post-removal hemorrhage, and may represent an inefficient use of operating room availability...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29774192/efficacy-of-the-all-in-one-therapeutic-strategy-for-severe-traumatic-brain-injury-preliminary-outcome-and-limitation
#7
Young-Soo Park, Yohei Kogeichi, Yoichi Shida, Hiroyuki Nakase
Objective: Despite recent advances in medicine, no significant improvement has been achieved in therapeutic outcomes for severe traumatic brain injury (TBI). In the treatment of severe multiple traumas, accurate judgment and prompt action corresponding to rapid pathophysiological changes are required. Therefore, we developed the "All-in-One" therapeutic strategy for severe TBI. In this report, we present the therapeutic concept and discuss its efficacy and limitations. Methods: From April 2007 to December 2015, 439 patients diagnosed as having traumatic intracranial injuries were treated at our institution...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29770180/factors-impacting-arthroscopic-rotator-cuff-repair-operational-throughput-time-at-an-ambulatory-care-center
#8
Emily J Curry, Catherine Logan, Kaytelin Suslavich, Kaitlyn Whitlock, Eric Berkson, Elizabeth Matzkin
Identifying patient factors influencing operational throughput time is becoming more imperative due to an increasing focus on value and cost savings in healthcare. The primary objective of this study was to determine patient factors influencing throughput time for primary rotator cuff repairs. Demographic information, medical history and operative reports of 318 patients from one ambulatory care center were retrospectively reviewed. Operating room set up, incision to closure and recovery room time were collected from anesthesia records...
March 29, 2018: Orthopedic Reviews
https://www.readbyqxmd.com/read/29766127/grey-s-anatomy-effect-television-portrayal-of-patients-with-trauma-may-cultivate-unrealistic-patient-and-family-expectations-after-injury
#9
Rosemarie O Serrone, Jordan A Weinberg, Pamela W Goslar, Erin P Wilkinson, Terrell M Thompson, Jonathan L Dameworth, Shawna R Dempsey, Scott R Petersen
Background: Expectations of the healthcare experience may be influenced by television dramas set in the hospital workplace. It is our perception that the fictional television portrayal of hospitalization after injury in such dramas is misrepresentative. The purpose of this study was to compare trauma outcomes on television dramas versus reality. Methods: We screened 269 episodes of Grey's Anatomy , a popular medical drama. A television (TV) registry was constructed by collecting data for each fictional trauma portrayed in the television series...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29762685/urine-multi-drug-screening-with-gc-ms-or-lc-ms-ms-using-salle-hybrid-ppt-spe
#10
Junhui Lee, Jiwon Park, Ahra Go, Heesung Moon, Sujin Kim, Sohee Jung, Wonjoon Jeong, Heesun Chung
To intoxicated patients in the emergency room, toxicological analysis can be considerably helpful for identifying the involved toxicants. In order to develop a urine multi-drug screening (UmDS) method, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS-MS) were used to determine targeted and unknown toxicants in urine. A GC-MS method in scan mode was validated for selectivity, limit of detection (LOD) and recovery. An LC-MS-MS multiple reaction monitoring (MRM) method was validated for lower LOD, recovery and matrix effect...
May 14, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29760359/a-simple-and-economical-method-of-gas-chromatography-mass-spectrometry-to-determine-the-presence-of-6-pesticides-in-human-plasma-and-its-clinical-application-in-patients-with-acute-poisoning
#11
Guiyan Yuan, Rui Zhang, Xuwang Chen, Benjie Wang, Ruichen Guo
An economical, rapid, and sensitive method of gas chromatography-mass spectrometry (GC-MS) was developed and validated to determine the presence of six pesticides (dichlorvos, acetochlor, atrazine, chlorpyrifos, α-endosulfan, and β-endosulfan) in human plasma. The pesticides were extracted with acetonitrile and concentrated using anhydrous sodium sulfate. Then, the target compounds were analyzed and quantified with GC-MS using borneol as an internal standard. Separation was performed on a HP-5MS capillary column (30 m × 0...
2018: Bioscience Trends
https://www.readbyqxmd.com/read/29756747/common-controversies-surrounding-anesthesia-for-procedures-in-the-interventional-pulmonology-suite
#12
Srikantha L Rao, Niraja Rajan
The number of anesthetics for both simple diagnostic and complex therapeutic procedures being performed in non-operating room locations (NORA) in dedicated Interventional Pulmonology Suites have been increasing in the past few years. Anesthesiologists must be familiar with the demands necessitated by the procedures performed by the interventionists and tailor the anesthetic to create a still field while carefully considering the patient's altered pharmacokinetics and reduced cardiopulmonary function and choose a technique that allows prompt recovery and early discharge in these patients, many of whom are elderly and frail...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29756162/retrospective-analysis-of-mepivacaine-prilocaine-and-chloroprocaine-for-low-dose-spinal-anaesthesia-in-outpatient-perianal-procedures
#13
Volker Gebhardt, Kevin Kiefer, Dieter Bussen, Christel Weiss, Marc D Schmittner
PURPOSE: Perianal procedures are carried out in an outpatient setting regularly. The purpose of this retrospective analysis was to investigate the impact of different local anaesthetics (LA) for spinal anaesthesia (SPA) on operating room (OR) efficiency (perioperative process times, turnaround times) and postoperative recovery. This study aims on the determination of the optimal LA for low-dose SPA in the specific setting of a high-volume day-surgery centre. METHODS: Anaesthesia records of all patients undergoing perianal outpatient surgery under saddle-block SPA at the Mannheim University Medical Centre from 2008 until 2017 were analysed...
May 13, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29753934/recovery-of-cytomegalovirus-dna-from-newborn-saliva-samples-by-different-methods
#14
Oran Goshen, David M Goldfarb, Laura Book, Peter Tilley, Soren Gantt
BACKGROUND: Polymerase chain reaction (PCR) testing of saliva swabs has been shown to be an attractive method to screen for congenital cytomegalovirus (CMV) infection. However, few data are available regarding the impact of pre-analytic methods on CMV DNA recovery from saliva samples under various conditions. OBJECTIVES: The purpose of this study was to evaluate the impact of various transport media and transport conditions on the recovery of CMV DNA from spiked and clinical saliva samples from newborns using PCR testing...
May 5, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29752218/elevated-international-normalized-ratio-is-not-associated-with-increased-perioperative-morbidity-in-podiatric-limb-salvage-surgery-a-retrospective-analysis
#15
Nalini Vadivelu, Alice M Kai, Feng Dai, Hosni Mikhael, Rima Aouad, Peter Blume
The risk of hemorrhage always exists in anticoagulated patients with an elevated international normalized ratio (INR), a risk that must be measured against the necessity for surgical procedures. The objective of the present retrospective medical record study was to assess the safety with which limb salvage procedures can be conducted in patients with an INR >1.4. The medical records of 231 patients who had undergone limb salvage procedures by 1 surgeon at the Yale New Haven Health System from November 2008 through July 2014 were reviewed...
May 8, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29751949/platelet-storage-lesions-what-more-do-we-know-now
#16
REVIEW
Monica Suet Ying Ng, John-Paul Tung, John Francis Fraser
Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate availability and safety are limited by the development of platelet storage lesions (PSLs) and risk of bacterial contamination. Platelet storage lesions are a series of biochemical, structural, and functional changes that occur from blood collection to transfusion. Understanding of PSLs is key for devising interventions that prolong PC shelf life to improve PC access and wastage...
April 17, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29743427/detection-of-trimethylamine-based-on-a-manganese-tetraphenylporphyrin-optical-waveguide-sensing-element
#17
Jiaming Wang, Patima Nizamidin, Yuan Zhang, Nuerguli Kari, Abliz Yimit
The sensitive detection of trimethylamine has been accomplished by using a homogeneous optical waveguide sensor system. Also the sensor can be easily fabricated by using tetraphenylporphyrin manganese (MnTPP) as sensitive materials to detect different volatile organic compounds (VOC). NMR (1 H-NMR), field-emission scanning electron microscopy (FESEM), and X-ray photoelectron spectroscopy (XPS), infrared (IR), and ultraviolet-visible (UV-vis) instrumental means were used to characterize its structure. Gas-sensing measurements indicated that the sensing element has shown good selectivity, high sensitivity and a low detection limit level of 0...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29741158/flexible-n-type-thermoelectric-composite-films-with-enhanced-performance-through-interface-engineering-and-post-treatment
#18
Hyeunhwan An, Dale Karas, Byung-Wook Kim, Sarah Trabia, Jaeyun Moon
Flexible thermoelectric (TE) materials, which are devices that convert thermal gradients to electrical energy, have attracted interest for practical energy-harvesting/recovery applications. However, as compared with p-type materials, the progress on the development of n-type TE flexible materials has been slow due to difficulties involved in n-type doping techniques. This study used high mobility carbon nanotubes (CNTs) to a uniformly mixed hybrid-composite, resulting in an enhanced power factor by increasing electrical conductivity...
July 6, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29737152/fully-stretchable-and-humidity-resistant-quantum-dot-gas-sensors
#19
Zhilong Song, Zhao Huang, Jingyao Liu, Zhixiang Hu, Jianbing Zhang, Guangzu Zhang, Fei Yi, Shenglin Jiang, Jiabiao Lian, Jia Yan, Jianfeng Zang, Huan Liu
Stretchable gas sensors that accommodate the shape and motion characteristics of human body are indispensable to a wearable or attachable smart sensing system. However, these gas sensors usually have poor response and recovery kinetics when operated at room temperature, especially suffer from humidity interference and mechanical robustness issues. Here, we demonstrate the first fully stretchable gas sensors which are operated at room temperature with enhanced stability against humidity. We created a crumpled quantum dot (QD) sensing layer on elastomeric substrate with flexible graphene as electrodes...
May 8, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29736802/management-of-aortic-injury-during-minimally-invasive-lateral-lumbar-interbody-fusion
#20
REVIEW
Michael M Safaee, Devin Zarkowsky, Charles M Eichler, Murat Pekmezci, Aaron J Clark
PURPOSE: Minimally invasive lateral approaches to the lumbar spine allow for interbody fusion with good visualization of the disk space, minimal blood loss, and decreased length of stay. Major neurologic, vascular, and visceral complications are rare with this approach; however, the steps in management for severe vascular injuries are not well defined. We present a case report of aortic injury during lateral interbody fusion and discuss the use of endovascular repair. METHODS: This study is a case report of an intraoperative aortic injury...
May 7, 2018: European Spine Journal
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