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https://www.readbyqxmd.com/read/29784867/patient-beliefs-and-attitudes-to-taking-statins-systematic-review-of-qualitative-studies
#1
Angela Ju, Camilla S Hanson, Emily Banks, Rosemary Korda, Jonathan C Craig, Tim Usherwood, Peter MacDonald, Allison Tong
BACKGROUND: Statins are effective in preventing cardiovascular disease (CVD) events and are recommended for at-risk individuals but estimated adherence rates are low. AIM: To describe patients' perspectives, experiences, and attitudes towards taking statins. DESIGN AND SETTING: Systematic review of qualitative studies reporting perspectives of patients on statins. METHOD: PsycINFO, CINAHL, Embase, MEDLINE, and PhD dissertations from inception to 6 October 2016 were searched for qualitative studies on adult patients' perspectives on statins...
May 21, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29778317/appropriate-use-of-noninvasive-ischemia-testing-to-guide-revascularization-decision-making-following-acute-st-elevation-myocardial-infarction-in-latin-american-countries-results-from-an-expert-panel-meeting-of-the-international-atomic-energy-agency
#2
I Berrocal, A Peix, F Mut, L J Shaw, G Karthikeyan, E Estrada Lobato, D Paez
Across Latin American and Caribbean countries, cardiovascular disease and especially ischemic heart disease is currently the main cause of death both in men and in women. For most Latin American and Caribbean countries, public and community health efforts aim to define care strategies which are both clinically and cost effective and promote primary and secondary prevention, resulting in improved patient outcomes. The optimal approach to deal with acute events such as ST-elevation myocardial infarction (STEMI) is a matter of controversy; however, there is an expanding role for assessing residual ischemic burden in STEMI patients following primary percutaneous coronary intervention...
May 16, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29739326/the-impact-of-nontraditional-lipid-profiles-on-left-ventricular-geometric-abnormalities-in-general-chinese-population
#3
Haoyu Wang, Zhao Li, Xiaofan Guo, Yintao Chen, Ye Chang, Shuang Chen, Yingxian Sun
BACKGROUND: Despite current interest in the unfavorable impact of nontraditional lipid profiles on cardiovascular disease, information regarding its relations to abnormal left ventricular (LV) geometry has not been systemically elucidated. This study sought to understand predictive implication of nontraditional lipid profiles in specific LV geometric patterns in the general population of rural China. METHODS: Analyses were based upon a cross-sectional study of 10,756 participants (mean age 53...
May 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29738378/promotion-of-home-based-exercise-training-as-secondary-prevention-of-coronary-heart-disease-a-pilot-web-based-intervention
#4
Anna Torri, Claudia Panzarino, Anna Scaglione, Maddalena Modica, Bruno Bordoni, Raffaella Redaelli, Renata De Maria, Maurizio Ferratini
BACKGROUND: Although cardiac rehabilitation (CR) is cost-effective in improving the health of patients with coronary heart disease (CHD), less than half of eligible CHD patients attend a CR program. Innovative web-based technologies might improve CR delivery and utilization. We assessed the feasibility and impact on functional capacity and secondary prevention targets of a long-term web-monitored exercise-based CR maintenance program. METHODS: Low- to moderate-risk CHD patients were recruited at discharge from inpatient CR after a coronary event or revascularization...
April 30, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29731350/the-cost-effectiveness-of-pcsk9-inhibitors-the-australian-healthcare-perspective
#5
Radya Kumar, Andrew Tonkin, Danny Liew, Ella Zomer
BACKGROUND: For patients in whom statins are not tolerated or effective as monotherapy, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid lowering therapies that may reduce low-density lipoprotein cholesterol (LDL-C) levels by up to 50% and lower cardiovascular events. While an important treatment option, the cost-effectiveness of PCSK9i in Australia remains unknown. This study aimed to determine the cost-effectiveness of PCSK9i compared to placebo in the prevention of atherosclerotic cardiovascular disease (CVD)...
April 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29700068/advances-in-transcriptomics-investigating-cardiovascular-disease-at-unprecedented-resolution
#6
REVIEW
Robert C Wirka, Milos Pjanic, Thomas Quertermous
Whole-genome transcriptional profiling has become a standard genomic approach to investigate biological processes. RNA sequencing (RNAseq) in particular has witnessed myriad applications in genetics and various biomedical fields. RNAseq involves a relatively simple experimental protocol of RNA extraction and cDNA library preparation and, because of decreasing next-generation sequencing cost and lower computational burden for data processing, has obtained a central role in the modern biology. The recent application of RNAseq methodology to single-cell transcriptional profiling has enabled the more precise characterization of cell lineage and cell state genetic profiles...
April 27, 2018: Circulation Research
https://www.readbyqxmd.com/read/29686026/favorable-modifiable-cardiovascular-risk-profile-is-associated-with-lower-healthcare-costs-among-cancer-patients-the-2012-2013-medical-expenditure-panel-survey
#7
Jai Singh, Javier Valero-Elizondo, Joseph A Salami, Haider J Warraich, Oluseye Ogunmoroti, Erica S Spatz, Nihar Desai, Jamal S Rana, Salim S Virani, Ron Blankstein, Michael J Blaha, Khurram Nasir
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) and cancer are among the leading causes of economic burden, morbidity, and mortality in the United States. We aimed to quantify the overall impact of cardiovascular modifiable risk factor (CRF) profile on healthcare expenditures among those with and without ASCVD and/or cancer. METHODS AND RESULTS: The 2012-2013 Medical Expenditure Panel Survey, a nationally representative adult sample (≥40 years), was utilized for the study...
April 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29683095/azilsartan-and-chlorthalidone-new-powerful-fixed-dose-antihypertensive-combination
#8
Vasiliki Katsi, Eleni Athanasiadi, Costas Tsioufis, Dimitris Tousoulis
Arterial hypertension is a disease that still affects a major part of the population worldwide, and leads to fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. From the CDC statistical analysis, as regarding to United States, 1 of every 3 adults has high blood pressure, and οnly about half (54%) of them have it under control. Furthermore, all that leads to a nation cost about $46 billion each year. Efforts to find new ways to regulate arterial hypertension are therefore imperative...
April 20, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29670383/the-economic-and-clinical-burden-of-early-versus-late-initiation-of-celecoxib-among-patients-with-osteoarthritis
#9
Ahmed Shelbaya, Caitlyn T Solem, Chris Walker, Yin Wan, Courtney Johnson, Joseph C Cappelleri
Objective: This study aimed to evaluate the characteristics associated with early versus late initiation of celecoxib treatment after osteoarthritis (OA) diagnosis and whether economic and safety outcomes differ between patients with early versus late initiation of celecoxib. Methods: Adults (≥18 years) with a confirmed OA diagnosis (International Classification of Diseases, 9th Edition, Clinical Modifications code: 715.XX), ≥12 months of continuous pre- and post-index enrollment, and ≥1 post-index claim for celecoxib were included from the MarketScan® Commercial Claims and Encounter Database (2009-2013)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29667178/cost-utility-analysis-of-bariatric-surgery
#10
O Borisenko, V Lukyanov, A R Ahmed
BACKGROUND: The objective of the study was to evaluate the cost-utility of bariatric surgery in England. METHODS: A state-transition Markov model was developed to compare the costs and outcomes of two treatment approaches for patients with morbid obesity: bariatric surgery, including gastric bypass, sleeve gastrectomy and adjustable gastric banding; and non-surgical usual care. Parameters of the effectiveness of surgery and complications were informed by data from the UK National Bariatric Surgery Registry, the Scandinavian Obesity Registry and the Swedish Obese Subjects study...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29622506/cost-effectiveness-of-a-fixed-dose-combination-polypill-in-secondary-prevention-of-cardiovascular-diseases-in-india-within-trial-cost-effectiveness-analysis-of-the-umpire-trial
#11
Kavita Singh, Catriona Crossan, Tracey-Lea Laba, Ambuj Roy, Alison Hayes, Abdul Salam, Stephen Jan, Joanne Lord, Nikhil Tandon, Anthony Rodgers, Anushka Patel, Simon Thom, Dorairaj Prabhakaran
BACKGROUND: The Use of Multidrug Pill In Reducing cardiovascular Events (UMPIRE) trial, showed that access to a cardiovascular polypill (aspirin, statin and two blood pressure lowering drugs) significantly improved adherence, lowered systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDLc) in patients with or at high risk of cardiovascular disease (CVD). We aimed to analyze the within-trial cost-effectiveness of the polypill strategy versus usual care in India. METHODS: Relative effectiveness and costs of polypill versus usual care groups in UMPIRE were estimated from the health sector perspective...
March 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29573034/appropriate-utilization-of-cardiac-magnetic-resonance-for-the-assessment-of-heart-failure-and-potential-associated-cost-savings
#12
Nishchay Kaushal, Harindra C Wijeysundera, Kim A Connelly, Idan Roifman
BACKGROUND: The rapid growth in cardiac imaging utilization has led to the development of appropriate use criteria (AUC) in an effort to control costs. Recently, cardiac MRI has developed into a valuable modality in the evaluation of cardiac disease. However, there are no studies examining the appropriate use of cardiac MRI in clinical practice. PURPOSE: To determine the appropriate utilization of cardiac MRI in a large quaternary care institution and to compare percentages of appropriate utilization pre- and postpublication of the AUC document...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29567495/characterizing-exposure-to-household-air-pollution-within-the-prospective-urban-rural-epidemiology-pure-study
#13
Raphael E Arku, Aaron Birch, Matthew Shupler, Salim Yusuf, Perry Hystad, Michael Brauer
BACKGROUND: Household air pollution (HAP) from combustion of solid fuels is an important contributor to disease burden in low- and middle-income countries (LIC, and MIC). However, current HAP disease burden estimates are based on integrated exposure response curves that are not currently informed by quantitative HAP studies in LIC and MIC. While there is adequate evidence supporting causal relationships between HAP and respiratory disease, large cohort studies specifically examining relationships between quantitative measures of HAP exposure with cardiovascular disease are lacking...
May 2018: Environment International
https://www.readbyqxmd.com/read/29566843/the-importance-of-model-structure-in-the-cost-effectiveness-analysis-of-primary-care-interventions-for-the-management-of-hypertension
#14
Maria Cristina Peñaloza-Ramos, Sue Jowett, Andrew John Sutton, Richard J McManus, Pelham Barton
BACKGROUND: Management of hypertension can lead to significant reductions in blood pressure, thereby reducing the risk of cardiovascular disease. Modeling the course of cardiovascular disease is not without complications, and uncertainty surrounding the structure of a model will almost always arise once a choice of a model structure is defined. OBJECTIVES: To provide a practical illustration of the impact on the results of cost-effectiveness of changing or adapting model structures in a previously published cost-utility analysis of a primary care intervention for the management of hypertension Targets and Self-Management for the Control of Blood Pressure in Stroke and at Risk Groups (TASMIN-SR)...
March 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29553570/skeletal-muscle-neurovascular-coupling-oxidative-capacity-and-microvascular-function-with-one-stop-shop-near-infrared-spectroscopy
#15
Ryan Rosenberry, Susie Chung, Michael D Nelson
Exercise represents a major hemodynamic stress that demands a highly coordinated neurovascular response in order to match oxygen delivery to metabolic demand. Reactive hyperemia (in response to a brief period of tissue ischemia) is an independent predictor of cardiovascular events and provides important insight into vascular health and vasodilatory capacity. Skeletal muscle oxidative capacity is equally important in health and disease, as it determines the energy supply for myocellular processes. Here, we describe a simple, non-invasive approach using near-infrared spectroscopy to assess each of these major clinical endpoints (reactive hyperemia, neurovascular coupling, and muscle oxidative capacity) during a single clinic or laboratory visit...
February 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29519347/10-year-resource-utilization-and-costs-for-cardiovascular-care
#16
Leslee J Shaw, Abhinav Goyal, Christina Mehta, Joe Xie, Lawrence Phillips, Anita Kelkar, Joseph Knapper, Daniel S Berman, Khurram Nasir, Emir Veledar, Michael J Blaha, Roger Blumenthal, James K Min, Reza Fazel, Peter W F Wilson, Matthew J Budoff
BACKGROUND: Cardiovascular disease (CVD) imparts a heavy economic burden on the U.S. health care system. Evidence regarding the long-term costs after comprehensive CVD screening is limited. OBJECTIVES: This study calculated 10-year health care costs for 6,814 asymptomatic participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a registry sponsored by the National Heart, Lung, and Blood Institute, National Institutes of Health. METHODS: Cumulative 10-year costs for CVD medications, office visits, diagnostic procedures, coronary revascularization, and hospitalizations were calculated from detailed follow-up data...
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29485954/differences-in-all-cause-health-care-utilization-and-costs-in-a-type-2-diabetes-mellitus-population-with-and-without-a-history-of-cardiovascular-disease
#17
Sandhya Mehta, Sabyasachi Ghosh, Stephen Sander, Effie Kuti, William K Mountford
BACKGROUND: Multiple studies have reported that type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases (CVD), and presence of T2DM and CVD increases risk of death. There is growing interest in examining the effects of antidiabetic treatments on the reduction of cardiovascular events in T2DM adults with a history of CVD and thus at higher risk of cardiovascular events. OBJECTIVE: To estimate the incremental all-cause health care utilization and costs among adults with T2DM and a history of CVD compared with adults without a history of CVD, using a national linked electronic medical records (EMR) and claims database...
March 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29480076/the-cost-of-cardiovascular-disease-related-death-in-patients-with-type-2-diabetes-mellitus
#18
Sharash Shetty, Dana Stafkey-Mailey, Binglin Yue, Anna D Coutinho, Weijia Wang, Angelo Del Parigi, Stephen D Sander, Craig I Coleman
OBJECTIVES: To assess the magnitude of difference in all-cause healthcare resource utilization (HCRU) and costs between patients with type 2 diabetes mellitus (T2DM) who died from a cardiovascular disease (CVD)-related cause in the year preceding death vs. those who did not die during this same period. METHODS: A large US administrative claims database was used to identify patients with T2DM who died of a CVD-related cause from July 2012 to April 2015. These patients were matched 1:1 to patients with T2DM who did not die, using direct matching methods...
March 29, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29449442/design-and-rationale-of-the-ripcord-2-trial-does-routine-pressure-wire-assessment-influence-management-strategy-at-coronary-angiography-for-diagnosis-of-chest-pain-a-randomized-controlled-trial-to-compare-routine-pressure-wire-assessment-with-conventional-angiography
#19
REVIEW
Mostafa Elguindy, Rod Stables, Zoe Nicholas, Ian Kemp, Nick Curzen
BACKGROUND: Investigation of anginal chest pain has traditionally involved either assessment of the coronary anatomy by angiography or noninvasive testing for reversible ischemia. Invasive pressure wire assessment at the time of angiography offers information on both anatomy and physiology. Fractional flow reserve-guided percutaneous coronary intervention is associated with lower resource utilization and improved clinical outcome compared with angiographic guidance alone. However, the value of routine fractional flow reserve of all major coronary vessels at the time of diagnostic angiography has not been established in a randomized trial despite persuasive observational data...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29443835/venous-thromboembolism-incidence-after-craniofacial-surgery
#20
Wilson I Omesiete, James A Walker, Jack C Yu
INTRODUCTION: Current protocols for venous thromboembolism (VTE) prophylaxis after craniofacial surgery (CFS) vary widely with substantial disagreements in both indications and managements. An evidence-based approach to this issue requires the following: the incidence of postoperative VTE, comorbidities associated with coagulopathy, risk reduction after VTE prophylaxis, and complications attributable to prophylaxis. This study addresses the first two. DESIGN: Retrospective cross-sectional study...
May 2018: Annals of Plastic Surgery
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