Hanan S Elsarraj, Yan Hong, Kelli E Valdez, Whitney Michaels, Marcus Hook, William P Smith, Jeremy Chien, Jason I Herschkowitz, Melissa A Troester, Moriah Beck, Marc Inciardi, Jason Gatewood, Lisa May, Therese Cusick, Marilee McGinness, Lawrence Ricci, Fang Fan, Ossama Tawfik, Jeffrey R Marks, Jennifer R Knapp, Hung-Wen Yeh, Patricia Thomas, D R Carrasco, Timothy A Fields, Andrew K Godwin, Fariba Behbod
INTRODUCTION: There are an estimated 60,000 new cases of ductal carcinoma in situ (DCIS) each year. A lack of understanding in DCIS pathobiology has led to overtreatment of more than half of patients. We profiled the temporal molecular changes during DCIS transition to invasive ductal carcinoma (IDC) using in vivo DCIS progression models. These studies identified B cell lymphoma-9 (BCL9) as a potential molecular driver of early invasion. BCL9 is a newly found co-activator of Wnt-stimulated β-catenin-mediated transcription...
September 17, 2015: Breast Cancer Research: BCR