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https://www.readbyqxmd.com/read/28212884/desipramine-decreases-expression-of-human-and-murine-indoleamine-2-3-dioxygenases
#1
Alexandra K Brooks, Tiffany M Janda, Marcus A Lawson, Jennifer L Rytych, Robin A Smith, Cecilia Ocampo-Solis, Robert H McCusker
Abundant evidence connects depression symptomology with immune system activation, stress and subsequently elevated levels of kynurenine. Anti-depressants, such as the tricyclic norepinephrine/serotonin reuptake inhibitor desipramine (Desip), were developed under the premise that increasing extracellular neurotransmitter level was the sole mechanism by which they alleviate depressive symptomologies. However, evidence suggests that anti-depressants have additional actions that contribute to their therapeutic potential...
February 14, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28205097/identifying-and-characterising-ppe7-rv0354c-high-activity-binding-peptides-and-their-role-in-inhibiting-cell-invasion
#2
Diana P Díaz, Marisol Ocampo, Yahson Varela, Hernando Curtidor, Manuel A Patarroyo, Manuel E Patarroyo
This study was aimed at characterising the PPE7 protein from the PE/PPE protein family. The presence and transcription of the rv0354c gene in the Mycobacterium tuberculosis complex was determined and the subcellular localisation of the PPE7 protein on mycobacterial membrane was confirmed by immunoelectron microscope. Two peptides were identified as having high binding activity (HABPs) and were tested in vitro regarding the invasion of Mycobacterium tuberculosis H37Rv. HABP 39224 inhibited invasion in A549 epithelial cells and U937 macrophages by more than 50%, whilst HABP 39225 inhibited invasion by 40% in U937 cells...
February 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28203198/surgical-management-of-a-patient-with-anterior-megalophthalmos-lens-subluxation-and-a-high-risk-of-retinal-detachment
#3
María Carmen Guixeres Esteve, Augusto Octavio Pardo Saiz, Lucía Martínez-Costa, Samuel González-Ocampo Dorta, Pedro Sanz Solana
The early development of lens opacities and lens subluxation are the most common causes of vision loss in patients with anterior megalophthalmos (AM). Cataract surgery in such patients is challenging, however, because of anatomical abnormalities. Intraocular lens dislocation is the most common postoperative complication. Patients with AM also seem to be affected by a type of vitreoretinopathy that predisposes them to retinal detachment. We here present the case of a 36-year-old man with bilateral AM misdiagnosed as simple megalocornea...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28199193/epigenetic-and-risk-factors-of-testicular-germ-cell-tumors-a-brief-review
#4
Daniel Adrian Landero-Huerta, Rosa Maria Vigueras-Villasenor, Emiy Yokoyama-Rebollar, Elena Arechaga-Ocampo, Julio Cesar Rojas-Castaneda, Francisco Jimenez-Trejo, Margarita Chavez-Saldana
Testicular germ cell cancer (TGCT) is the most common malignancy among young adult males, which has become important due to its increased incidence and mortality in the population worldwide. The etiology is multifactorial. Recent studies have shown some associations between the development of isolated TGCT and certain risk factors, such as exposure to endocrine disruptors, cryptorchidism, and family history of cancer, in order to identify the key pieces in carcinogenesis. Some of the most important findings in recent years is the association of different genes, such as c-KIT/KITLG, expression of the miR-371-373 cluster and protein expression as c-KIT and POU5F1 in the development of this neoplasia, and the identification of new molecular markers as TGFBR3 gene, identifying aberrant methylation patterns in promoter regions of several genes, expression of miR-1297 which regulates PTEN and protein expression as DMTR1...
March 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28193503/clinical-translation-of-a-psma-inhibitor-for-99m-tc-based-spect
#5
Guillermina Ferro-Flores, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Emmanuel Orocio-Rodríguez, Jenny Davanzo, Francisco O García-Pérez
BACKGROUND: Prostate-specific membrane antigen (PSMA) is highly over-expressed in advanced prostate cancers. (68)Ga-labeled PSMA inhibitors (iPSMA) are currently used for prostate cancer detection by PET imaging. The availability of simple, efficient and reproducible radiolabeling procedures is essential for developing new SPECT radiopharmaceuticals for clinical translation. The aim of this research was to prepare (99m)Tc-EDDA/HYNIC-Lys(Nal)-Urea-Glu ((99m)Tc-EDDA/HYNIC-iPSMA) obtained from lyophilized kit formulations and evaluate the in vitro and in vivo radiopharmaceutical binding to prostate cancer cells over-expressing PSMA, as well as the (99m)Tc-EDDA/HYNIC-iPSMA normal biodistribution in humans and the preliminary uptake in patients with prostate cancer...
February 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28162862/maltodextrin-ascorbic-acid-stimulates-wound-closure-by-increasing-collagen-turnover-and-tgf-%C3%AE-1-expression-in%C3%A2-vitro-and-changing-the-stage-of-inflammation-from-chronic-to-acute-in%C3%A2-vivo
#6
Rosa M Salgado, Otilia Cruz-Castañeda, Francisco Elizondo-Vázquez, Lucia Pat, Anabel De la Garza, Saúl Cano-Colín, Leticia Baena-Ocampo, Edgar Krötzsch
It has been reported that carbohydrates confer physicochemical properties to the wound environment that improves tissue repair. We evaluated in vitro and in vivo wound healing during maltodextrin/ascorbic acid treatment. In a fibroblast monolayer scratch assay, we demonstrated that maltodextrin/ascorbic acid stimulated monolayer repair by increasing collagen turnover coordinately with TGF-β1 expression (rising TGF-β1 and MMP-1 expression, as well as gelatinase activity, while TIMP-1 was diminished), similar to in vivo trends...
February 1, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28157509/mnase-sensitive-complexes-in-yeast-nucleosomes-and-non-histone-barriers
#7
Răzvan V Chereji, Josefina Ocampo, David J Clark
Micrococcal nuclease (MNase) is commonly used to map nucleosomes genome-wide, but nucleosome maps are affected by the degree of digestion. It has been proposed that many yeast promoters are not nucleosome-free but instead occupied by easily digested, unstable, "fragile" nucleosomes. We analyzed the histone content of all MNase-sensitive complexes by MNase-ChIP-seq and sonication-ChIP-seq. We find that yeast promoters are predominantly bound by non-histone protein complexes, with little evidence for fragile nucleosomes...
February 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28129541/interspecies-chimerism-with-mammalian-pluripotent-stem-cells
#8
Jun Wu, Aida Platero-Luengo, Masahiro Sakurai, Atsushi Sugawara, Maria Antonia Gil, Takayoshi Yamauchi, Keiichiro Suzuki, Yanina Soledad Bogliotti, Cristina Cuello, Mariana Morales Valencia, Daiji Okumura, Jingping Luo, Marcela Vilariño, Inmaculada Parrilla, Delia Alba Soto, Cristina A Martinez, Tomoaki Hishida, Sonia Sánchez-Bautista, M Llanos Martinez-Martinez, Huili Wang, Alicia Nohalez, Emi Aizawa, Paloma Martinez-Redondo, Alejandro Ocampo, Pradeep Reddy, Jordi Roca, Elizabeth A Maga, Concepcion Rodriguez Esteban, W Travis Berggren, Estrella Nuñez Delicado, Jeronimo Lajara, Isabel Guillen, Pedro Guillen, Josep M Campistol, Emilio A Martinez, Pablo Juan Ross, Juan Carlos Izpisua Belmonte
Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several tissues of gene-edited organogenesis-disabled mice. Besides gaining insights into species evolution, embryogenesis, and human disease, interspecies blastocyst complementation might allow human organ generation in animals whose organ size, anatomy, and physiology are closer to humans...
January 26, 2017: Cell
https://www.readbyqxmd.com/read/28129473/pseudo-pitting-of-the-nail-in-psoriasis
#9
Nilton Di Chiacchio, Josette André, Eckart Haneke, Nilton Gioia Di Chiacchio, Leandro Fonseca Noriega, Jorge Ocampo-Garza
Psoriasis is a chronic and recurrent inflammatory skin disease with a worldwide prevalence of approximately 1 to 3% causing significant distress and morbidity in the affected patients.(1,2,3) Skin manifestations are the most characteristic findings of psoriasis, however, nail psoriasis is often overlooked despite its common occurrence.(1,2) Nail involvement occurs in 61% of cases of cutaneous psoriasis and with a lifetime incidence among patients with psoriatic arthritis between 80% and 90%. About 1-5% of patients manifest with nail changes only...
January 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28113153/landscapes-of-the-digital-baroque
#10
Gary Singh
Alvaro Ocampo traversed many landscapes to arrive at his current space in the digital art landscape. Eventually, the artist then made his way to the digital world, where he is no longer subjected to the tyranny of the one-off. He believes digital art is the new version of traditional etching in the way that it eliminates the idea of the one original piece of art.
May 2016: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28110349/organochlorine-pesticides-in-gonad-brain-and-blood-of-mice-in-two-agricultural-areas-of-sinaloa
#11
Ernestina Perez-Gonzalez, Ulises-Giovanni Osuna-Martinez, Maria-Nancy Herrera-Moreno, Guadalupe-Durga Rodriguez-Meza, Hector-A Gonzalez-Ocampo, Marcos Bucio-Pacheco
The adverse effect of pesticides on non-target wildlife and human health is a primary concern in the world, but in Mexico, we do not know which wildlife species are at the greatest risk. The aim of this study was to determine organochlorine pesticides in mice of two agricultural fields in Sinaloa, Culiacan and Guasave. Procedures of extraction, analysis, and quantification were followed according to the modified EPA 8081b method. In three mouse tissues (gonad, brain, and blood), γBHC and decachlorobiphenyl with a frequency higher than 50% and endosulfan sulfate with 43% were observed...
January 21, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28101901/cyto-genotoxicity-and-oxidative-stress-in-common-carp-cyprinus-carpio-exposed-to-a-mixture-of-ibuprofen-and-diclofenac
#12
Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván, Marcela Galar-Martínez, Esmeralda Michelle Sánchez-Ocampo, Nely SanJuan-Reyes, Mariana Ortíz-Reynoso, Octavio Dublán-García
Thirty million people worldwide consume each day nonsteroidal anti-inflammatory drugs (NSAIDs), a heterogeneous group of pharmaceuticals used for its analgesic, antipyretic, and anti-inflammatory properties. Recent studies report high NSAID concentrations in wastewater treatment plant effluents, in surface, ground, and drinking water, and in sediments. NSAIDs are also known to induce toxicity on aquatic organisms. However, toxicity in natural ecosystems is not usually the result of exposure to a single substance but to a mixture of toxic agents, yet only a few studies have evaluated the toxicity of mixtures...
January 19, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28087028/nodular-hidradenoma-dermoscopic-presentation
#13
Juan Carlos Robles-Mendez, Sylvia Aide Martínez-Cabriales, Alejandra Villarreal-Martínez, Ana Sofía Ayala-Cortés, Ivette Miranda-Maldonado, Osvaldo Vázquez-Martínez, Jorge Ocampo-Candiani
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28087026/dermoscopy-of-pigmented-fungiform-papillae-of-the-tongue
#14
Juan-Carlos Robles-Méndez, Ana-Sofía Ayala-Cortés, Alejandra Villarreal-Martínez, Jorge Ocampo-Candiani
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28063203/simultaneous-au-iii-extraction-and-in-situ-formation-of-polymeric-membrane-supported-gold-nanoparticles-a-sustainable-process-with-application-in-catalysis
#15
Lucia Mora-Tamez, Vicente Esquivel-Peña, Ana Lilia Ocampo, Eduardo Rodríguez de San Miguel, Daniel Grande, Josefina de Gyves
A polymeric membrane-supported catalyst with immobilized gold nanoparticles (AuNPs) was prepared through the extraction and in-situ reduction of gold(III) salts in a one-step strategy. Polymeric inclusion membranes (PIMs) and polymeric nanoporous membranes (PNMs) were tested as different membrane support systems. Transport experiments indicated that PIMs composed of cellulose triacetate, 2-nitrophenyloctyl ether, and an aliphatic tertiary amine (Adogen® 364 or Alamine® 336) were the most efficient supports for Au(III) extraction...
January 7, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28054924/a-mixed-methods-study-to-assess-interrater-reliability-and-nurse-perception-of-the-braden-scale-in-a-tertiary-acute-care-setting
#16
Chester H Ho, Amanda Cheung, Danielle Southern, Wrechelle Ocampo, Jaime Kaufman, David B Hogan, Barry Baylis, John M Conly, Henry T Stelfox, William A Ghali
Research regarding the reliability of the Braden Scale and nurses' perspectives on the instrument for predicting pressure ulcer (PU) risk in acute care settings is limited. A mixed-methods study was conducted in a tertiary acute care facility to examine interrater reliability (IRR) of the Braden Scale and its subscales, and a qualitative survey using semi-structured interviews was conducted among nurses caring for patients in acute care units to gain nurse perspective regarding scale usability. Data were extracted from a previous retrospective, randomized, controlled trial involving adult patients with compromised mobility receiving care in a tertiary acute care hospital in Canada...
December 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/28042246/acute-pancreatitis-patient-registry-to-examine-novel-therapies-in-clinical-experience-apprentice-an-international-multicenter-consortium-for-the-study-of-acute-pancreatitis
#17
Georgios I Papachristou, Jorge D Machicado, Tyler Stevens, Mahesh Kumar Goenka, Miguel Ferreira, Silvia C Gutierrez, Vikesh K Singh, Ayesha Kamal, Jose A Gonzalez-Gonzalez, Mario Pelaez-Luna, Aiste Gulla, Narcis O Zarnescu, Konstantinos Triantafyllou, Sorin T Barbu, Jeffrey Easler, Carlos Ocampo, Gabriele Capurso, Livia Archibugi, Gregory A Cote, Louis Lambiase, Rakesh Kochhar, Tiffany Chua, Subhash Ch Tiwari, Haq Nawaz, Walter G Park, Enrique de-Madaria, Peter J Lee, Bechien U Wu, Phil J Greer, Mohannad Dugum, Efstratios Koutroumpakis, Venkata Akshintala, Amir Gougol
BACKGROUND: We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and to develop a platform for future randomized clinical trials. METHODS: The AP patient registry to examine novel therapies in clinical experience (APPRENTICE) was formed in July 2014. Detailed web-based questionnaires were then developed to prospectively capture information on demographics, etiology, pancreatitis history, comorbidities, risk factors, severity biomarkers, severity indices, health-care utilization, management strategies, and outcomes of AP patients...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28035758/genotypic-tropism-testing-of-proviral-dna-to-guide-maraviroc-initiation-in-aviraemic-subjects-48-week-analysis-of-results-from-the-protest-study
#18
E Poveda, J Hernández-Quero, M J Pérez-Elías, M A Ribas, O J Martínez-Madrid, J Flores, J Navarro, F Gutiérrez, M García-Deltoro, A Imaz, A Ocampo, A Artero, F Blanco, E Bernal, J Pasquau, C Mínguez-Gallego, N Pérez, A Aiestaran, F García, R Paredes
OBJECTIVES: Maraviroc (MVC) is a suitable drug for aviraemic subjects on antiretroviral treatment (ART) developing toxicity. Its prescription requires prior tropism testing. It is unknown if proviral DNA genotypic tropism testing is reliable for guiding MVC initiation in aviraemic subjects, so this study was carried out to address this issue. METHODS: PROTEST was a phase 4, prospective, single-arm clinical trial carried out in 24 HIV care centres in Spain. MVC-naïve HIV-1-infected patients with HIV-1 RNA < 50 copies/mL on stable ART during the previous 6 months who required an ART change because of toxicity and who had R5 HIV, as determined by proviral DNA genotypic tropism testing, initiated MVC with two nucleoside reverse transcriptase inhibitors (NRTIs) and were followed for 48 weeks...
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27992975/-three-cases-of-de-novo-multiple-myeloma-after-kidney-transplantation
#19
John Fredy Nieto-Ríos, Mónica Zuluaga, Lina María Serna, Arbey Aristizábal, Catalina Ocampo-Kohn, Kenny Mauricio Gálvez, Adriana Alejandra Flórez, Gustavo Zuluaga
Light chain-associated kidney compromise is frequent in patients with monoclonal gammopathies; it affects the glomeruli or the tubules, and its most common cause is multiple myeloma. It may develop after a kidney transplant due to recurrence of a preexisting multiple myeloma or it can be a de novo disease manifesting as graft dysfunction and proteinuria. A kidney biopsy is always necessary to confirm the diagnosis.We describe three cases of kidney graft dysfunction due to multiple myeloma in patients without presence of the disease before the transplant...
December 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27986845/unique-photosynthetic-phenotypes-in-portulaca-portulacaceae-c3-c4-intermediates-and-nad-me-c4-species-with-pilosoid-type-kranz-anatomy
#20
Elena V Voznesenskaya, Nuria K Koteyeva, Gerald E Edwards, Gilberto Ocampo
Portulacaceae is a family that has considerable diversity in photosynthetic phenotypes. It is one of 19 families of terrestrial plants where species having C4 photosynthesis have been found. Most species in Portulaca are in the alternate-leaved (AL) lineage, which includes one clade (Cryptopetala) with taxa lacking C4 photosynthesis and three clades having C4 species (Oleracea, Umbraticola and Pilosa). All three species in the Cryptopetala clade lack Kranz anatomy, the leaves have C3-like carbon isotope composition and they have low levels of C4 cycle enzymes...
January 2017: Journal of Experimental Botany
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