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https://www.readbyqxmd.com/read/29342104/synthesis-anti-proliferative-activity-evaluation-and-3d-qsar-study-of-naphthoquinone-derivatives-as-potential-anti-colorectal-cancer-agents
#1
Julio Acuña, Jhoan Piermattey, Daneiva Caro, Sven Bannwitz, Luis Barrios, Jairo López, Yanet Ocampo, Ricardo Vivas-Reyes, Fabio Aristizábal, Ricardo Gaitán, Klaus Müller, Luis Franco
Colorectal cancer (CRC) is a disease with high incidence and mortality, constituting the fourth most common cause of death from cancer worldwide. Naphthoquinones are attractive compounds due to their biological and structural properties. In this work, 36 naphthoquinone derivatives were synthesized and their activity evaluated against HT-29 cells. Overall, high to moderate anti-proliferative activity was observed in most members of the series, with 15 compounds classified as active (1.73 < IC50 < 18.11 μM)...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29339183/evolution-of-the-growth-hormone-prolactin-prolactin-2-and-somatolactin-family
#2
Daniel Ocampo Daza, Dan Larhammar
Growth hormone (GH), prolactin (PRL), prolactin 2 (PRL2) and somatolactin (SL) belong to the same hormone family and have a wide repertoire of effects including development, osmoregulation, metabolism and stimulation of growth. Both the hormone and the receptor family have been proposed to have expanded by gene duplications in early vertebrate evolution. A key question is how hormone-receptor preferences have arisen among the duplicates. The first step to address this is to determine the time window for these duplications...
January 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29333822/labial-adhesions-experience-in-a-children-s-hospital
#3
Anahí Rubinstein, Gisel Rahman, Paula Risso, Dolores Ocampo
Labial adhesions are defined as the complete or partial fusion of the pudendal cleft due to the agglutination of the labia minora in the midline. They most commonly occur between 3 months and 6 years of life. Between January 1st, 2002 and December 31st, 2015, 425 girls diagnosed with labial adhesions and seen at the Unit of Pediatric and Adolescent Gynecology of Hospital de Niños de La Plata, Argentina, were analyzed. Their average age was 2.7 years (standard deviation: 2.6 years). The most common presentation of labial adhesions was that involving more than 75% of the total length of the labia (p < 0...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29319775/primary-hiperoxaluria-diagnosed-after-kidney-transplantation-report-of-2-cases-and-literature-review
#4
John Fredy Nieto Rios, Monica Zuluaga, Lina Maria Serna Higuita, Adriana Florez, Diana Carolina Bello-Marquez, Arbey Aristizábal, Catalina Ocampo Kohn, Gustavo Adolfo Zuluaga
Primary hyperoxaluria (PH) is a very rare genetic disorder; it is characterized by total or partial deficiency of the enzymes related to the metabolism of glyoxylate, with an overproduction of calcium oxalate that is deposited in different organs, mainly the kidney, leading to recurrent lithiasis, nephrocalcinosis and end stage renal disease (ESRD). In patients with ESRD that receive kidney transplantation alone, the disease has a relapse of 100%, with graft loss in a high percentage of patients in the first 5 years of transplantation...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29312833/geo-referencing-bird-window-collisions-for-targeted-mitigation
#5
R Scott Winton, Natalia Ocampo-Peñuela, Nicolette Cagle
Bird collisions with windows are an important conservation concern. Efficient mitigation efforts should prioritize retrofitting sections of glass exhibiting the highest mortality of birds. Most collision studies, however, record location meta-data at a spatial scale too coarse (i.e., compass direction of facing façade) to be useful for large buildings with complex geometries. Through spatial analysis of three seasons of survey data at a large building at a university campus, we found that GPS data were able to identify collision hotspots while compass directions could not...
2018: PeerJ
https://www.readbyqxmd.com/read/29305184/bactericidal-effect-of-silver-nanoparticles-against-the-propagation-of-clavibacter-michiganensis-infection-in-lycopersicon-esculentum-mill
#6
Raymundo Rene Rivas-Cáceres, Jose LuisStephano-Hornedo, Lugo Jorge, Vaca Rocio, Pedro Del Aguila, Gustavo Yañez-Ocampo, Martha Elena Mora-Herrera, Luis Miguel Camacho Díaz, Moisés Cipriano-Salazar, Peter Adeniyi Alaba
This study explored the use of silver nanoparticle as a bactericidal against the propagation of Clavibacter michiganensis onto tomatoes (Lycopersicon esculentum Mill). In Mexico, tomato production covers about 73% of the total vegetable production but it is affected by outbreak of bacteria canker caused by Clavibacter michiganensis subspecies michiganensis (Cmm). Silver ions are possess inhibitor properties, bactericides and high specter antimicrobials. In this study, 6 groups of culture were prepared using 6 different petri dishes where silver nanoparticles of varying concentrations (120, 84, 48, 24, 12 and 0 μg) were added...
January 2, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29299634/synthesis-and-evaluation-of-a-molecularly-imprinted-polymer-for-the-determination-of-metronidazole-in-water-samples
#7
L Díaz de León-Martínez, M Rodríguez-Aguilar, R Ocampo-Pérez, J M Gutiérrez-Hernández, F Díaz-Barriga, L Batres-Esquivel, R Flores-Ramírez
A molecularly imprinted polymer was developed and evaluated for selective determination of metronidazole (MNZ) in wastewater. This was achieved by using sodium methacrylate as monomer, toluene as porogen, ethylene glycol dimethacrylate as crosslinker, azobisisobutyronitrile as initiator and metronidazole as template molecule to generate the selectivity of the polymer for the compound, as well as non-imprinted polymers were synthesized. Two different polymerization approaches were used, bulk and emulsion and the polymers obtained by emulsion presented higher retention percentages the MIP 2-M presented the higher retention (83%)...
January 3, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29286011/prevalence-of-zoonotic-and-non-zoonotic-genotypes-of-giardia-intestinalis-in-cats-a-systematic-review-and-meta-analysis
#8
Sebastián Ramírez-Ocampo, Juan David Cotte-Alzate, Ángel A Escobedo, Alfonso J Rodríguez-Morales
There are no meta-analyses specifically describing the prevalence of zoonotic and non-zoonotic genotypes of Giardia intestinalis in cats, which would be useful in defining the importance of cats as a source of zoonotic transmission. We performed a systematic review of the literature in three databases (PubMed, Scopus and SciELO) to assess the proportion of cats that were infected with specific G. intestinalis genotypes. A meta-analysis using a random effects model was performed to calculate the pooled prevalence and 95% confidence intervals (95%CI)...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29283418/chrysin-induces-antidiabetic-antidyslipidemic-and-anti-inflammatory-effects-in-athymic-nude-diabetic-mice
#9
Juan José Ramírez-Espinosa, Johann Saldaña-Ríos, Sara García-Jiménez, Rafael Villalobos-Molina, Gabriela Ávila-Villarreal, Angélica Nallelhy Rodríguez-Ocampo, Germán Bernal-Fernández, Samuel Estrada-Soto
Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment...
December 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29276571/draft-genome-sequence-of-dethiosulfovibrio-salsuginis-dsm-21565t-an-anaerobic-slightly-halophilic-bacterium-isolated-from-a-colombian-saline-spring
#10
Carolina Díaz-Cárdenas, Gina López, José David Alzate-Ocampo, Laura N González, Nicole Shapiro, Tanja Woyke, Nikos C Kyrpides, Silvia Restrepo, Sandra Baena
A bacterium belonging to the phylum Synergistetes, genus Dethiosulfovibrio was isolated in 2007 from a saline spring in Colombia. Dethiosulfovibrio salsuginis USBA 82T (DSM 21565T= KCTC 5659T) is a mesophilic, strictly anaerobic, slightly halophilic, Gram negative bacterium with a diderm cell envelope. The strain ferments peptides, amino acids and a few organic acids. Here we present the description of the complete genome sequencing and annotation of the type species Dethiosulfovibrio salsuginis USBA 82T. The genome consisted of 2...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29249106/-ige-sensitization-and-sociodemographic-conditions-as-determinant-factors-in-asthma-severity
#11
Rodrigo Gaviria, Jaime Ocampo, Julián Londoño, Víctor Calvo, Ricardo Cardona, Jorge Sánchez
BACKGROUND: In Latin America there are few data about the factors that influence the control and severity of asthma. OBJECTIVE: To describe the association between IgE sensitization to intra-home allergens and housing conditions in the severity of asthma. METHODS: Sensitization to aero-allergens was evaluated by skin prick test and socio-demographic data by a questionnaire in a population between 6 and 14 years of age with diagnosis of asthma...
October 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29239927/an-adult-patient-with-a-novel-mutation-in-nlrp3-gene-associated-with-cryopyrin-associated-periodic-syndrome-mimicking-adult-onset-still-disease
#12
Vanessa Ocampo, Maria-Clara Ortiz-Sierra, Andrés F Echeverri, Iván Posso-Osorio, Juan-Pablo Suso, Gabriel J Tobón
No abstract text is available yet for this article.
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29236830/the-charming-physician-el-m%C3%A3-dico-encantador-neurological-conditions-in-a-short-story-by-silvina-ocampo
#13
Guillermo Delgado-García, Carolina Rodríguez-Návarez, Bruno Estañol
The Argentinian author Silvina Ocampo (1903-1993) left us a vast body of works which are considered outstanding in many ways. In 1960, she published a short story, entitled "El médico encantador" (The Charming Physician), in the renowned literary magazine Sur. The central character of this piece is a family doctor named Albino Morgan, who had a secret truth: in any house he visited, all variety of disease also entered. He brought with him the viruses he disseminated. The narrator of this short story-one of his patients-describes four of Morgan's diseases...
November 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29230580/in-vivo-studies-of-the-effectiveness-of-novel-n-halomethylated-and-non-halomethylated-quaternary-ammonium-salts-in-the-topical-treatment-of-cutaneous-leishmaniasis
#14
Maritza Fernandez, Javier Murillo, Luz Amalia Ríos-Vásquez, Rogelio Ocampo-Cardona, David L Cedeño, Marjorie A Jones, Iván D Velez, Sara M Robledo
The physicochemical properties of four N-halomethylated and one non-halomethylated ammonium salts, with proven in vitro antileishmanial activity, were determined according to pharmaceutical standard procedures. The effectiveness and toxicity of these compounds were assessed in hamsters infected with Leishmania (Viannia) braziliensis and compared to that showed by meglumine antimoniate. Animals were followed during 90 days after the completion of treatment. Therapeutic response was determined according to the reduction of size of skin lesions...
December 11, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29226521/the-ontogeny-of-the-female-reproductive-system-in-the-parasitic-castrator-pea-crab-calyptraeotheres-garthi-implications-for-its-mating-system
#15
Emiliano H Ocampo, Tomás A Luppi, Eduardo D Spivak, Sebastian Klaus
The knowledge of the mating system of pea crabs is still fragmentary as it remains dubious whether females copulate in the juvenile and free-living 'hard' or in the obligatory symbiotic stages (adult stage 'V' or intermediate stages II to IV). To discriminate between these two possibilities, we analysed the female seminal receptacles, vagina and opercula, and the sperm content in different stages of the pea crab Calyptraeotheres garthi. Our histology and scanning electron microscopy results revealed that in the hard stage the seminal receptacle is simple without secretory epithelia, and vagina and opercula are not controlled by musculature...
December 11, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29220543/skin-cancer-prevention-campaign-in-childhood-survey-based-on-3-676-children-in-brazil
#16
Paulo Ricardo Criado, Jorge Ocampo-Garza, Anne Lise Dias, Walter Belda Junior, Nilton Di Chiachio, Aparecida Machado de Moraes, Meire Brasil Parada, Fátima de Oliveira Rabay, Octavio Moraes Junior, Renato Sau Rios, Cristiana Silveira da Silva, Francisco C S Ferreira, Samuel Henrique Mandeulbaum, Cidia Vasconcellos
BACKGROUND AND OBJECTIVES: Primary skin cancer prevention campaigns are essential and more effective among children, not only because of the importance of sun exposure effects during this period, but also because at this age is when individuals are developing behaviors. The Brazilian Society of Dermatology - Regional State of Sao Paulo developed and conducted, the program named "The Sun, Friend of Childhood", a school health education and disease prevention project for children and parents...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29214545/daily-activity-patterns-and-thermal-tolerance-of-three-sympatric-dung-beetle-species-scarabaeidae-scarabaeinae-eucraniini-from-the-monte-desert-argentina
#17
V C Giménez Gómez, S B Lomáscolo, G A Zurita, F Ocampo
Tolerance to extreme temperatures, thermal limits, and the mechanisms of thermoregulation are related to internal functions of insects and partly define their ecological niche. We study the association between daily activity of dung beetles from the Monte Desert in Argentina and their tolerance to high temperatures. Results indicate that for all three sympatric species studied, Eucranium belenae Ocampo, Anomiopsoides cavifrons (Burmeister), and Anomiopsoides fedemariai Ocampo, daily activity is associated to ground temperature...
December 6, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/29214164/outcome-of-critically-ill-patients-with-testicular-cancer
#18
Silvio A Ñamendys-Silva, Mireya Barragán-Dessavre, Andoreni R Bautista-Ocampo, Francisco J García-Guillén, Bertha M Córdova-Sánchez, Edgar Constantino-Hérnandez, Paulina Correa-García, Octavio González-Chon, Angel Herrera-Gómez
Purpose: To evaluate the clinical characteristics and outcomes of critically ill patients with testicular cancer (TC) admitted to an oncological intensive care unit (ICU). Methods: This was a prospective observational study. There were no interventions. Results: During the study period, 1,402 patients with TC were admitted to the Department of Oncology, and 60 patients (4.3%) were admitted to the ICU. The most common histologic type was nonseminomatous germ cell tumors (55/91...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29190817/screening-for-precancerous-anal-lesions-with-p16-ki67-immunostaining-in-hiv-infected-msm
#19
Sergio Serrano-Villar, Beatriz Hernández-Novoa, Amparo de Benito, Jorge Del Romero, Antonio Ocampo, José Ramón Blanco, Mar Masiá, Elena Sendagorta, Gonzalo Sanz, Santiago Moreno, José A Pérez-Molina
BACKGROUND: Screening of anal cancer in HIV-infected MSM with anal cytology results in high rates of false positive results and elevated burden of high-resolution anoscopies. High-risk HPV up-regulates p16 and Ki67 expression in epithelial cells. We assessed the usefulness of P16/Ki-67 immunostaining cytology for the diagnosis of precancerous anal lesions. METHODOLOGY: Cross-sectional multicenter study. Concomitant anal liquid cytology with p16/Ki-67 immunostaining and HRA with biopsy of acetowhite lugol-negative lesions was performed in HIV-infected MSM...
2017: PloS One
https://www.readbyqxmd.com/read/29186239/cutaneous-mucormycosis
#20
Ana Daniela Castrejón-Pérez, Esperanza C Welsh, Ivett Miranda, Jorge Ocampo-Candiani, Oliverio Welsh
Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described...
May 2017: Anais Brasileiros de Dermatologia
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