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https://www.readbyqxmd.com/read/27891075/bace1-rnai-restores-the-composition-of-phosphatidylethanolamine-derivates-related-to-memory-improvement-in-aged-3xtg-ad-mice
#1
Javier G Villamil-Ortiz, Alvaro Barrera-Ocampo, Diego Piedrahita, Claudia M Velásquez-Rodríguez, Julian D Arias-Londoño, Gloria P Cardona-Gómez
β-amyloid (Aβ) is produced by the β-secretase 1 (BACE1)-mediated enzymatic cleavage of the amyloid precursor protein through the amyloidogenic pathway, making BACE1 a therapeutic target against Alzheimer's disease (AD). Alterations in lipid metabolism are a risk factor for AD by an unknown mechanism. The objective of this study was to determine the effect of RNA interference against BACE1 (shBACEmiR) on the phospholipid profile in hippocampal CA1 area in aged 3xTg-AD mice after 6 and 12 months of treatment compared to aged PS1KI mice...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27890086/multiple-isoforms-for-the-catalytic-subunit-of-pka-in-the-basal-fungal-lineage-mucor-circinelloides
#2
Lucas Fernández Núñez, Josefina Ocampo, Alexandra M Gottlieb, Silvia Rossi, Silvia Moreno
Protein kinase A (PKA) activity is involved in dimorphism of the basal fungal lineage Mucor. From the recently sequenced genome of Mucor circinelloides we could predict ten catalytic subunits of PKA. From sequence alignment and structural prediction we conclude that the catalytic core of the isoforms is conserved, and the difference between them resides in their amino termini. This high number of isoforms is maintained in the subdivision Mucoromycotina. Each paralogue, when compared to the ones form other fungi is more homologous to one of its orthologs than to its paralogs...
December 2016: Fungal Biology
https://www.readbyqxmd.com/read/27861482/-bloom-syndrome-clinical-manifestations-and-cromosomal-study-in-a-mexican-child
#3
Gloria María Rosales-Solis, César Adrián Martínez-Longoria, Guillermo Antonio Guerrero-González, Jorge Ocampo-Garza, Jorge Ocampo-Candiani
Bloom syndrome is an extremely rare inherited disorder. We present a case of Bloom syndrome with a chromosomal study in a Mexican five-year-old patient who presented growth retardation, narrow facies with poikiloderma, café-au-lait, macules and photosensitivity.
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27861472/-rheumatoid-arthritis-ra-disease-activity-predicts-function-of-abcb1-p-gp-and-abcg2-bcrp1-drug-efflux-transporters
#4
Virginia Pascual-Ramos, Yemil Atisha-Fregoso, Guadalupe Lima, Hilda Fragoso-Loyo, Juan Jákez-Ocampo, Irazú Contreras-Yáñez, Luis Llorente
BACKGROUND: P-gp and BCRP1 are transporter proteins that may confer drug resistance. OBJECTIVE: To compare P-gp and BCRP1 function in rheumatoid arthritis patients with active and inactive disease and to define their relation with disease activity. METHODS: We included 17 active patients paired (age, gender, disease duration) to 17 inactive patients. All had baseline evaluations and 27 had additional six-month follow-up. P-gp and BCRP1 functional activity was measured in peripheral mononuclear cells by flow cytometry...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27856906/the-formation-of-peak-rings-in-large-impact-craters
#5
Joanna V Morgan, Sean P S Gulick, Timothy Bralower, Elise Chenot, Gail Christeson, Philippe Claeys, Charles Cockell, Gareth S Collins, Marco J L Coolen, Ludovic Ferrière, Catalina Gebhardt, Kazuhisa Goto, Heather Jones, David A Kring, Erwan Le Ber, Johanna Lofi, Xiao Long, Christopher Lowery, Claire Mellett, Rubén Ocampo-Torres, Gordon R Osinski, Ligia Perez-Cruz, Annemarie Pickersgill, Michael Poelchau, Auriol Rae, Cornelia Rasmussen, Mario Rebolledo-Vieyra, Ulrich Riller, Honami Sato, Douglas R Schmitt, Jan Smit, Sonia Tikoo, Naotaka Tomioka, Jaime Urrutia-Fucugauchi, Michael Whalen, Axel Wittmann, Kosei E Yamaguchi, William Zylberman
Large impacts provide a mechanism for resurfacing planets through mixing near-surface rocks with deeper material. Central peaks are formed from the dynamic uplift of rocks during crater formation. As crater size increases, central peaks transition to peak rings. Without samples, debate surrounds the mechanics of peak-ring formation and their depth of origin. Chicxulub is the only known impact structure on Earth with an unequivocal peak ring, but it is buried and only accessible through drilling. Expedition 364 sampled the Chicxulub peak ring, which we found was formed from uplifted, fractured, shocked, felsic basement rocks...
November 18, 2016: Science
https://www.readbyqxmd.com/read/27851595/1961-rhabdomyolysis-after-robotic-radical-cystectomy
#6
John Denny, Achillina Rianto, Andres Ocampo, Sagar Mungekar, Julia Denny, Alex Kahan, Vasiliy Sim
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850459/821-familial-impact-and-coping-in-parents-of-children-with-hypoplastic-left-heart-syndrome
#7
Agustin Cabrera, Elena Ocampo, Valeria Munguia
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849853/211-infections-in-pediatric-single-ventricle-patients-associated-with-increased-morbidity-and-mortality
#8
Erin Kritz, Claire Bocchini, Yunfei Wang, Paul Checchia, Elena Ocampo
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27830470/the-influence-of-masked-stimuli-on-response-selection-evidence-from-a-semantic-categorization-task
#9
Brenda Ocampo
Unconscious visual stimuli can be processed by human observers and influence their behaviour. A striking example is a phenomenon known as "free-choice priming," where masked "prime" stimuli-of which participants are unaware-modulate which of two response alternatives they are likely to choose. Recent efforts to uncover the mechanisms underlying this intriguing effect have revealed that free-choice priming can emerge even in the absence of automatized stimulus-response (S-R) associations between masked primes and specific motor responses, indicating that free choices can be influenced by a masked prime's meaning (Ocampo, 2015)...
November 9, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27818812/cns-vasculitis-associated-with-waldenstr%C3%A3-m-macroglobulinemia
#10
Tanawan Riangwiwat, Chris Y Wu, Alberto S Santos-Ocampo, Randal J Liu, Aaron M McMurtray, Beau K Nakamoto
Waldenström macroglobulinemia (WM) is an indolent B cell lymphoproliferative disorder with monoclonal IgM secretion. We present a patient with WM who presented with multifocal acute cortical ischemic strokes and was found to have central nervous system (CNS) vasculitis. Workup was negative for cryoglobulins and hyperviscosity syndrome. Immunosuppression with intravenous steroids and cyclophosphamide stabilized the patient's mental status and neurologic deficits. On followup over 7 years, patient gained independence from walking aids and experienced no recurrences of CNS vasculitis...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27818270/consolidation-of-spatial-memory-in-the-rat-findings-using-zeta-inhibitory-peptide
#11
Jena B Hales, Amber C Ocampo, Nicola J Broadbent, Robert E Clark
Whether or not spatial memories reorganize in the rodent brain is an unanswered question that carries the importance of whether the rodent provides a suitable animal model of human retrograde amnesia. The finding of equally impaired recent and remote spatial memory could reflect the continued importance of the hippocampus for spatial memory or a performance deficit (for example, hippocampal lesions may impair the rat's ability to use distal spatial cues to navigate to a specific point in space). In the current study, we tested recent and remote spatial memory in rats following hippocampal ZIP (zeta-pseudosubstrate inhibitory peptide) infusion to inhibit PKMzeta...
December 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27799150/rapid-movement-and-transcriptional-re-localization-of-human-cohesin-on-dna
#12
Iain F Davidson, Daniela Goetz, Maciej P Zaczek, Maxim I Molodtsov, Pim J Huis In 't Veld, Florian Weissmann, Gabriele Litos, David A Cisneros, Maria Ocampo-Hafalla, Rene Ladurner, Frank Uhlmann, Alipasha Vaziri, Jan-Michael Peters
The spatial organization, correct expression, repair, and segregation of eukaryotic genomes depend on cohesin, ring-shaped protein complexes that are thought to function by entrapping DNA It has been proposed that cohesin is recruited to specific genomic locations from distal loading sites by an unknown mechanism, which depends on transcription, and it has been speculated that cohesin movements along DNA could create three-dimensional genomic organization by loop extrusion. However, whether cohesin can translocate along DNA is unknown...
October 31, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27797305/cutaneous-lupus-the-pimple-that-never-went-away
#13
Vanessa Ocampo, Shariq Haider
A 28-year-old woman presented with an erythematous rash involving the nose, nasolabial folds, and philtrum that appeared after she had manipulated a painful vesicular lesion at the base of her nose that she believed to be a pimple. The patient received cloxacillin for presumed erysipelas and had a..
October 20, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27792697/-cutaneous-manifestations-in-inflammatory-bowel-disease
#14
Sonia Chavez-Álvarez, Minerva Gómez-Flores, Jorge Ocampo-Candiani
Inflammatory bowel disease (IBD), mainly chronic unspecific ulcerative colitis and Crohn's disease have increased in incidence in the last decades. These have multiple extraintestinal manifestations, with those of the skin appearing after the intestinal clinical presentation. These are classified as: granulomatous dermatosis, reactive dermatosis, and those secondary to treatment of IBD, and other dermatosis. This article presents the pathogenesis, clinical approach, treatment and expected evolution of these manifestations...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27788608/boron-s-journey-advances-in-the-study-and-application-of-pharmacokinetics
#15
Ana L Ocampo-Néstor, José G Trujillo-Ferrara, Antonio Abad-García, Cynthia Reyes-López, Simonetta Geninatti-Crich, Marvin A Soriano-Ursúa
Boron-containing compounds (BCCs) are attractive chemical entities in drug development. Some of these compounds have been used in the treatment of human disease, and studies on their pharmacodynamics suggest that they employ multiple forms of activity. However, less is known about the pharmacokinetic profile of these molecules. Areas covered: The herein compiled reported data is presented in accordance with the classical 'ADME' system for identifying the scope of BCCs in the respective fields. Our analysis suggests that these compounds have several distinct ways to move within the human body, and that the specific structural features of each molecule account for its distinct pharmacokinetic profile...
October 28, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27769924/evolution-of-electric-communication-signals-in-the-south-american-ghost-knifefishes-gymnotiformes-apteronotidae-a-phylogenetic-comparative-study-using-a-sequence-based-phylogeny
#16
Adam R Smith, Melissa R Proffitt, Winnie W Ho, Claire B Mullaney, Javier A Maldonado-Ocampo, Nathan R Lovejoy, José A Alves-Gomes, G Troy Smith
The electric communication signals of weakly electric ghost knifefishes (Gymnotiformes: Apteronotidae) provide a valuable model system for understanding the evolution and physiology of behavior. Apteronotids produce continuous wave-type electric organ discharges (EODs) that are used for electrolocation and communication. The frequency and waveform of EODs, as well as the structure of transient EOD modulations (chirps), vary substantially across species. Understanding how these signals have evolved, however, has been hampered by the lack of a well-supported phylogeny for this family...
October 18, 2016: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/27769537/why-join-the-ibero-latin-american-college-of-dermatology
#17
J Ocampo-Candiani
No abstract text is available yet for this article.
October 18, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27759796/-trends-and-inequalities-in-risk-behaviors-among-adolescents-a-comparison-of-birth-cohorts-in-pelotas-rio-grande-do-sul-state-brazil
#18
Leidy Johanna Ocampo Arroyave, María Clara Restrepo-Méndez, Bernardo Lessa Horta, Ana Maria Baptista Menezes, Denise Petrucci Gigante, Helen Gonçalves
This study focuses on trends and inequalities in health risk behaviors among adolescents. A cross-sectional study compared two birth cohorts in the city of Pelotas, Rio Grande do Sul State, Brazil. The sample included 1,281 adolescents from the 1982 cohort and 4,106 from the 1993 cohort, followed in 2001 and 2011, respectively. The study recorded alcohol intake, illegal drug use, smoking, sexual initiation < 16 years, lack of condom use, and multiple sex partners. Total prevalence rates were calculated for each cohort, stratified by gender and per capita income, besides absolute and relative measures of inequality...
October 10, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27752974/hydrogels-based-on-poly-ethylene-glycol-as-scaffolds-for-tissue-engineering-application-biocompatibility-assessment-and-effect-of-the-sterilization-process
#19
Alondra Escudero-Castellanos, Blanca E Ocampo-García, Ma Victoria Domínguez-García, Jaime Flores-Estrada, Miriam V Flores-Merino
Hydrogels are suitable materials to promote cell proliferation and tissue support because of their hydrophilic nature, porous structure and sticky properties. However, hydrogel synthesis involves the addition of additives that can increase the risk of inducing cytotoxicity. Sterilization is a critical process for hydrogel clinical use as a proper scaffold for tissue engineering. In this study, poly(ethylene glycol) (PEG), poly(ethylene glycol)-chitosan (PEG-CH) and multi-arm PEG hydrogels were synthesized by free radical polymerization and sterilized by gamma irradiation or disinfected using 70 % ethanol...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27741335/adalimumab-treatment-in-women-with-moderate-to-severe-hidradenitis-suppurativa-from-the-placebo-controlled-portion-of-a-phase-2-randomized-double-blind-study
#20
Alice Gottlieb, Alan Menter, April Armstrong, Christopher Ocampo, Yihua Gu, Henrique D Teixeira
BACKGROUND: Hidradenitis Suppurativa (HS), also known as acne inversa, is a painful, chronic, debilitating, inflammatory skin disease and has shown response to anti-TNF-α therapy. Efficacy and safety of the anti-TNF-α agent, adalimumab, was assessed in a post hoc analysis of women from the first 16 weeks of a phase 2 study of men and women with HS. METHODS: Patients with moderate-to-severe HS in at least 2 body areas, unresponsive or intolerant to oral antibiotics for treatment of their HS, and with no previous anti-TNF-a or systemic non-biologic treatment, were randomized 1:1:1 to 40 mg adalimumab-weekly or every-other-week, or placebo...
October 1, 2016: Journal of Drugs in Dermatology: JDD
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