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https://www.readbyqxmd.com/read/28447577/prognostic-value-of-adamts13-in-patients-with-severe-sepsis-and-septic-shock
#1
M Feroz Azfar, M Faisal Khan, S Shahid Habib, Z Al Aseri, A Mohammad Zubaidi, D Ocampo Aguila, M Owais Suriya, Hameed Ullah
PURPOSE: ADAMTS13 level was evaluated as a predictor of mortality in patients with severe sepsis and septic shock, and compared with Acute Physiology and Chronic Health Evaluation II (APACHE II) scores. METHODS: This prospective observational study was conducted in the Medical and Surgical Intensive Care Units of King Khalid University Hospital. Detailed clinical evaluations were performed on 84 patients (56.08±18.18 years of age) with severe sepsis and septic shock...
April 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28437889/safety-of-sucrose-esters-from-physalis-peruviana-l-in-a-28-day-repeated-dose-study-in-mice
#2
Yanet C Ocampo, Daneiva C Caro, David E Rivera, Luis A Franco
Although extracts and consumed foods from Physalis species contain sucrose esters from their glandular trichomes, there is no experimental data available on their toxicological effects. As peruvioses A and B isolated from Physalis peruviana L. calyces have proved to be effective anti-inflammatory and immunomodulatory compounds, this work aimed to investigate their sub-acute toxicity study and genotoxicity. For this, CD-1(ICR) mice were treated intraperitoneally with peruvioses at doses of 2.5, 5, and 10mg/kg/day for 28 consecutive days, to simulate therapeutic and over-therapeutic dosage levels...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28434897/epidemiology-of-polyomavirus-bk-bkv-and-the-emergent-african-variant-in-kidney-and-bone-marrow-transplant-recipients-in-the-fundacion-valle-del-lili-in-cali-colombia
#3
Luz Ángela Ocampo, Fernando Rosso, Robinson Pacheco, Adriana Villegas
To describe the epidemiology of BKV and to assess the presence of the African variant in bone marrow and kidney transplant patients who have suspected BKV reactivation. A descriptive study was conducted, using institutional records, at the Fundación Valle del Lili, Cali-Colombia. The overall prevalence of BKV during the study period was 51%. The African variant was identified in 49.4% of samples that were positive for BKV. 50.6% of the samples were found to have the wild strain of BKV. Among BKV positive patients, 57% were kidney transplant recipients and 43% were bone marrow transplant recipients...
April 6, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28432878/in-vitro-susceptibility-of-methicillin-resistant-staphylococcus-aureus-isolates-from-skin-and-soft-tissue-infections-to-vancomycin-daptomycin-linezolid-and-tedizolid
#4
Johanna Marcela Vanegas Múnera, Ana María Ocampo Ríos, Daniela Montoya Urrego, Judy Natalia Jiménez Quiceno
INTRODUCTION: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a study to determine in vitro susceptibility to vancomycin, daptomycin, linezolid, and tedizolid in MRSA clinical isolates from adult patients with skin and soft tissue infections. MATERIAL AND METHODS: Methicillin-resistant S...
April 19, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28416182/dynamical-tuning-for-mpc-using-population-games-a-water-supply-network-application
#5
Julian Barreiro-Gomez, Carlos Ocampo-Martinez, Nicanor Quijano
Model predictive control (MPC) is a suitable strategy for the control of large-scale systems that have multiple design requirements, e.g., multiple physical and operational constraints. Besides, an MPC controller is able to deal with multiple control objectives considering them within the cost function, which implies to determine a proper prioritization for each of the objectives. Furthermore, when the system has time-varying parameters and/or disturbances, the appropriate prioritization might vary along the time as well...
April 15, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28409184/comparison-of-affect-changes-during-the-ovulatory-phase-in-women-with-and-without-hormonal-contraceptives
#6
Ana Ocampo Rebollar, Francisco J Menéndez Balaña, Montserrat Conde Pastor
Studies about affect changes during the menstrual cycle and the role of hormones in these changes have yielded contradictory results. Often research has focused on the pre-menstrual phase, with few studies paying specific attention to the affect changes around ovulation. In this research thirty women completed a daily questionnaire measuring the positive and negative affect during their menstrual cycle. These women were divided in two groups: hormonally-contracepting and naturally-cycling. The Positive and Negative Affect Schedule was used to measure the affect...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28407282/vector-competence-and-innate-immune-responses-to-dengue-virus-infection-in-selected-laboratory-and-field-collected-stegomyia-aegypti-%C3%A2-aedes-aegypti
#7
I M Serrato, P A Caicedo, Y Orobio, C Lowenberger, C B Ocampo
Control of dengue virus (DenV) transmission, primarily based on strategies to reduce populations of the principle vector Stegomya aegypti (= Aedes aegypti) (Diptera: Culicidae), is difficult to sustain over time. Other potential strategies aim to manipulate characteristics such as vector competence (VC), the innate capacity of the vector to transmit the virus. Previous studies have identified genetic factors, including differential expression of apoptosis-related genes, associated with the refractory and susceptible phenotypes in selected strains of S...
April 13, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28403791/multimeric-system-of-rgd-grafted-pmma-nanoparticles-as-a-targeted-drug-delivery-system-for-paclitaxel
#8
Gibbens-Bandala Brenda Vianey, Ocampo-García Blanca Eli, Ferro-Flores Guillermina, Morales-Avila Enrique, Ancira-Cortez Alejandra, Jaimes-Aguirre Laura
BACKGROUND: Polymer-based nanoparticles as drug-delivery systems offer new therapeutic opportunities. Among them, ligand-mediated targeting, which increases selectivity and efficacy, allows controllable drug delivery. The aim of the this research was to prepare and characterize poly(methyl methacrylate) (PMMA) nanoparticles grafted with the -Arginine, Glycine, Aspartic Acid (RGD)- peptide sequence as a promising smart drug delivery system for Paclitaxel (PTX), directed at the sites of integrin receptor overexpression...
April 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28403528/superficial-black-onychomycosis-due-to-neoscytalidium-dimidiatum
#9
N Di Chiacchio, L F Noriega, N Gioia Di Chiacchio, J Ocampo-Garza
Onychomycosis is the most common onychopathy observed in adults and the elderly, and it is a frequent reason for medical visits.(1) Its prevalence ranges from 2.0-26.9%, depending on the population and geographic region.(1,2) Non-dermatophyte molds are responsible for 1.5-17.6% of onychomycosis cases, with higher prevalence in tropical and subtropical countries. This article is protected by copyright. All rights reserved.
April 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28399696/molecular-strategies-to-increase-the-levels-of-heterologous-transcripts-in-komagataella-phaffii-for-protein-production
#10
Luiza Cesca Piva, Maritza Ocampo Bentacur, Viviane Castelo Branco Reis, Janice Lisboa De Marco, Lidia Maria Pepe de Moraes, Fernando Araripe Gonçalves Torres
Komagataella phaffii (formerly Pichia pastoris) is a well-known fungal system for heterologous protein production in the context of modern biotechnology. To obtain higher protein titers in this system many researchers have sought to optimize gene expression by increasing the levels of transcription of the heterologous gene. This has been typically achieved by manipulating promoter sequences or by generating clones bearing multiple copies of the desired gene. The aim of this work is to describe how these different molecular strategies have been applied in K...
February 22, 2017: Bioengineered
https://www.readbyqxmd.com/read/28399326/unfulfilled-promise-of-data-driven-approaches-response-to-peterson-et%C3%A2-al
#11
Stuart L Pimm, Grant Harris, Clinton N Jenkins, Natalia Ocampo-Peñuela, Binbin V Li
No abstract text is available yet for this article.
April 11, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28395295/comprehending-comprehension-selected-possibilities-for-clinical-practice-within-a-multidimensional-model
#12
Geraldine P Wallach, Alaine Ocampo
Purpose: In this discussion as part of a response to Catts and Kamhi's "Prologue: Reading Comprehension Is Not a Single Activity" (2017), the authors provide selected examples from 4th-, 5th-, and 6th-grade texts to demonstrate, in agreement with Catts and Kamhi, that reading comprehension is a multifaceted and complex ability. The authors were asked to provide readers with evidence-based practices that lend support to applications of a multidimensional model of comprehension. Method: We present examples from the reading comprehension literature that support the notion that reading is a complex set of abilities that include a reader's ability, especially background knowledge; the type of text the reader is being asked to comprehend; and the task or technique used in assessment or intervention paradigms...
April 20, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28357370/attenuation-of-polyglutamine-induced-toxicity-by-enhancement-of-mitochondrial-oxphos-in-yeast-and-fly-models-of-aging
#13
Andrea L Ruetenik, Alejandro Ocampo, Kai Ruan, Yi Zhu, Chong Li, R Grace Zhai, Antoni Barrientos
Defects in mitochondrial biogenesis and function are common in many neurodegenerative disorders, including Huntington's disease (HD). We have previously shown that in yeast models of HD, enhancement of mitochondrial biogenesis through overexpression of Hap4, the catalytic subunit of the transcriptional complex that regulates mitochondrial gene expression, alleviates the growth arrest induced by expanded polyglutamine (polyQ) tract peptides in rapidly dividing cells. However, the mechanism through which HAP4 overexpression exerts this protection remains unclear...
July 26, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28345453/tumor-suppressor-mir-29c-regulates-radioresistance-in-lung-cancer-cells
#14
Elena Arechaga-Ocampo, Cesar Lopez-Camarillo, Nicolas Villegas-Sepulveda, Claudia H Gonzalez-De la Rosa, Isidro X Perez-Añorve, Reynalda Roldan-Perez, Ali Flores-Perez, Omar Peña-Curiel, Oscar Angeles-Zaragoza, Rosalva Rangel Corona, Juan A Gonzalez-Barrios, Raul Bonilla-Moreno, Oscar Del Moral-Hernandez, Luis A Herrera, Alejandro Garcia-Carranca
Radiotherapy is an important treatment option for non-small cell lung carcinoma patients. Despite the appropriate use of radiotherapy, radioresistance is a biological behavior of cancer cells that limits the efficacy of this treatment. Deregulation of microRNAs contributes to the molecular mechanism underlying resistance to radiotherapy in cancer cells. Although the functional roles of microRNAs have been well described in lung cancer, their functional roles in radioresistance are largely unclear. In this study, we established a non-small cell lung carcinoma Calu-1 radioresistant cell line by continuous exposure to therapeutic doses of ionizing radiation as a model to investigate radioresistance-associated microRNAs...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28332321/pigmented-onychomatricoma-four-cases
#15
Jorge Ocampo-Garza, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio
Onychomatricoma (OM) presenting as a longitudinal melanonychia is a very uncommon clinical presentation with very few cases in the literature. Our aim in this article is to report four cases of pigmented OM, and describe their clinical and dermoscopic findings and the importance of the differential diagnoses, especially with melanoma.
March 23, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28322830/antidiabetic-antidyslipidemic-and-toxicity-profile-of-env-2-a-potent-pyrazole-derivative-against-diabetes-and-related-diseases
#16
Eduardo Hernández-Vázquez, Hugo Ocampo-Montalban, Litzia Cerón-Romero, Miguel Cruz, Jaime Gómez-Zamudio, Guadalupe Hiriart-Valencia, Rafael Villalobos-Molina, Angelica Flores-Flores, Samuel Estrada-Soto
Diabetes is a major health problem and a predisposition factor for further degenerative complications and, therefore, novel therapies are urgently needed. Currently, cannabinoid receptor 1 (CB1 receptor) antagonists have been considered as promissory entities for metabolic disorders treatment. Accordingly, the purpose of this work was the evaluation of the sub-acute antidiabetic, anti-hyperglycemic, antidyslipidemic and toxicological profile of ENV-2, a potent hypoglycemic and antioxidant CB1 receptor antagonist...
May 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28301623/subungual-melanoma-in-situ-treated-with-imiquimod-5-cream-after-conservative-surgery-recurrence
#17
Jorge Ocampo-Garza, Nilton Gioia Di Chiacchio, Eckart Haneke, Francisco le Voci, Francisco Macedo Paschoal
<p>Subungual melanoma is a rare variant of acral lentiginous melanoma that often has a poor prognosis compared with other types of melanoma. The aim of the present study is to report a case of a patient with recurrence of subungual melanoma treated with imiquimod 5%, which presented a total regression of the lesion and no recurrence for 4 years.</p> <p><em>J Drugs Dermatol. 2017;16(3):268-270.</em></p>.
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300998/psychological-assistance-provided-to-patients-diagnosed-with-depression-in-primary-care
#18
Cibele Cunha Lima da Motta, Carmen Leontina Ojeda Ocampo Moré, Carlos Henrique Sancineto da Silva Nunes
The scope of this research was to understand the assistance provided by psychologists to patients diagnosed with depression in the municipal health care network. In this study, the phenomenon is examined from its broader perspective, taking the psychosocial dimensions of health into account. A group of 22 psychologists participated in this study of a qualitative nature. Data collection began with participant in-field observation of the institutional context followed by semi-structured interviews. Grounded theory methodology was used to analyze information, thereby facilitating its integration and categorization...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28298071/protective-effect-of-dracontium-dubium-against-bothrops-asper-venom
#19
Daneiva Caro, Yanet Ocampo, Jenny Castro, Lia Barrios, Rubén Salas, Luis A Franco
In Colombia, Bothrops asper is responsible for 70-90% of ophidians accidents reported annually. Envenoming occurs mainly in rural areas where both antivenom and health centers are scarce. Thus, patients are frequently treated by local healers that employ medicinal herbs; including several species belonging to Dracontium genus. In this work, we evaluated the neutralizing activity of Dracontium dubium Kunth against the lethal, inflammatory, coagulant and hemolytic effects produced by B. asper venom. Mice treated with D...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28295446/a-recombinant-cystatin-from-ascaris-lumbricoides-attenuates-inflammation-of-dss-induced-colitis
#20
S Coronado, L Barrios, J Zakzuk, R Regino, V Ahumada, L Franco, Y Ocampo, L Caraballo
Helminthiasis may ameliorate inflammatory diseases, such as inflammatory bowel disease and asthma. Information about immunomodulators from Ascaris lumbricoides is scarce, but could be important considering the co-evolutionary relationships between helminths and humans. We evaluated the immunomodulatory effects of a recombinant cystatin from A. lumbricoides on an acute model of dextran sodium sulphate (DSS)-induced colitis in mice. From an A. lumbricoides cDNA library, we obtained a recombinant cystatin (rAl-CPI)...
March 10, 2017: Parasite Immunology
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