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https://www.readbyqxmd.com/read/29779294/a-tricky-sticky-eye
#1
Tim Staunton Smith
No abstract text is available yet for this article.
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29779188/vitreomacular-interface-abnormalities-in-patients-with-diabetic-macular-oedema-and-their-implications-on-the-response-to-anti-vegf-therapy
#2
Michael Mikhail, Stephen Stewart, Felicia Seow, Ruth Hogg, Noemi Lois
PURPOSE: To determine whether the presence of vitreomacular interface abnormalities (VMIA) in patients with diabetic macular oedema (DMO) modifies the response to ranibizumab. METHODS: Medical records and spectral-domain optical coherence tomography (SD-OCT) scans of consecutive patients with centre-involving DMO initiating therapy with ranibizumab between December 2013 and March 2014 at the Belfast Health and Social Care Trust were reviewed. Patients were identified through an electronic database...
May 19, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29779048/increased-il-27-il-27r-expression-in-association-with-the-immunopathology-of-murine-ocular-toxoplasmosis
#3
Xinxin Tong, Shengjie Chen, Huanqin Zheng, Shiguang Huang, Fangli Lu
Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (IL-27R) consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. Human and mouse mast cells (MCs) express the IL-27R. To explore the expressions of IL-27/IL-27R subunits (WSX-1 and gp130) during acute ocular toxoplasmosis (OT), we established mouse model by intraocular injection of 500 Toxoplasma gondii RH strain tachyzoites. Histopathological changes were analyzed, MCs were counted by toluidine blue staining, and tryptase+ /IL-27+ MCs were examined by immunofluorescence double-staining in the eyes and cervical lymph nodes (CLNs) of T...
May 19, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29778926/a-computational-approach-to-estimate-postmortem-interval-using-opacity-development-of-eye-for-human-subjects
#4
İsmail Cantürk, Lale Özyılmaz
This paper presents an approach to postmortem interval (PMI) estimation, which is a very debated and complicated area of forensic science. Most of the reported methods to determine PMI in the literature are not practical because of the need for skilled persons and significant amounts of time, and give unsatisfactory results. Additionally, the error margin of PMI estimation increases proportionally with elapsed time after death. It is crucial to develop practical PMI estimation methods for forensic science. In this study, a computational system is developed to determine the PMI of human subjects by investigating postmortem opacity development of the eye...
May 17, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29778917/favorite-odor-induces-negative-dream-emotion-during-rapid-eye-movement-sleep
#5
Satomi Okabe, Kazuhiko Fukuda, Hiroko Mochizuki-Kawai, Kazuo Yamada
OBJECTIVE: As connections between nightmares and various psychiatric disorders have been reported, the clinical significance of studying dream emotionality is now growing in importance. Because the olfactory bulb connects directly to the amygdala odor presentation may be a crucial tool to study dream emotions. Previous studies have demonstrated that presentation of positive/negative odors during rapid eye movement (REM) sleep affects various aspects of dreaming. Although olfactory perception can be influenced by personal experiences, the role of individual preferences in the effects of olfactory stimuli on dreaming has not yet been clarified...
April 19, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29778898/examining-the-diagnostic-accuracy-of-static-postural-stability-measures-in-differentiating-among-knee-osteoarthritis-patients-with-mild-and-moderate-to-severe-radiographic-signs
#6
Nahid Pirayeh, Mohammad-Jafar Shaterzadeh-Yazdi, Hossein Negahban, Mohammad Mehravar, Neda Mostafaee, Amal Saki-Malehi
BACKGROUND: Clinicians need a reliable and accurate tools that can best identify and classify balance impairments between mild and moderate to severe grades of knee osteoarthritis (OA). RESEARCH QUESTION: This study was designed to investigate the accuracy of postural measurements to discriminate between these two groups of knee OA. METHODS: A total of 130 patients with knee OA based on the Kellgren-Lawrence (KL) grading scale were categorized into 65 patients with mild (a KL grade≤ 2) and 65 patient with moderate to severe (a KL grade≥3) radiographic sign...
May 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29778824/-gel-in-core-carbosomes-as-novel-ophthalmic-vehicles-with-enhanced-corneal-permeation-and-residence
#7
Mona A Moustafa, Wessam M El-Refaie, Yosra S R Elnaggar, Ossama Y Abdallah
Carbopol is a good bio-adhesive polymer that increases the residence time in the eye. However, the effect of blinking and lacrimation still reduce the amount of polymer and the incorporated drug available for bioadhesion. Gel-core liposomes are advanced systems offering benefits making it a good tool for improved ocular drug delivery and residence time. Incorporation of carbopol in gel-core liposomes and their potential in ocular delivery have not so far been investigated. Fluconazole (FLZ) was selected as a challenging important ocular antifungal suffering from poor corneal permeation and short residence time...
May 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29778783/intra-vitreal-%C3%AE-b-crystallin-fused-to-elastin-like-polypeptide-provides-neuroprotection-in-a-mouse-model-of-age-related-macular-degeneration
#8
Parameswaran G Sreekumar, Zhe Li, Wan Wang, Christine Spee, David R Hinton, Ram Kannan, J Andrew MacKay
Age-related macular degeneration (AMD) is the leading cause of severe and irreversible central vision loss, and the primary site of AMD pathology is the retinal pigment epithelium (RPE). Geographic atrophy (GA) is an advanced form of AMD characterized by extensive RPE cell loss, subsequent degeneration of photoreceptors, and thinning of retina. This report describes the protective potential of a peptide derived from the αB crystallin protein using a sodium iodate (NaIO3 ) induced mouse model of GA. Systemic NaIO3 challenge causes degeneration of the RPE and neighboring photoreceptors, which have similarities to retinas of GA patients...
May 17, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29778454/influence-of-the-beam-profile-crosslinking-setting-on-changes-in-corneal-topography-and-tomography-in-progressive-keratoconus-preliminary-results
#9
Robert Herber, Kathleen S Kunert, Věra Veliká, Eberhard Spoerl, Lutz E Pillunat, Frederik Raiskup
PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems. SETTING: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany. DESIGN: Retrospective case series. METHODS: Eyes from patients with progressive keratoconus were included...
May 16, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29778281/role-of-the-water-drinking-test-in-medically-treated-primary-open-angle-glaucoma-patients
#10
H Salcedo, D Arciniega, M Mayorga, L Wu
PURPOSE: The water-drinking test (WDT) has recently re-emerged as a possible way to determine the competency of the trabecular meshwork. We performed a prospective interventional study to test the hypothesis that the WDT could be useful in assessing fluctuations in patients undergoing treatment for primary open angle glaucoma (POAG). METHODS: We included 122 patients; 62 on medical treatment for POAG (n=123 eyes) and 60 controls (n=120 eyes). The study group had been on intraocular pressures (IOP) lowering treatment continuously for at least 3months with stable IOP...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29778134/central-serous-chorioretinopathy-in-african-americans-at-wilmer-eye-institute
#11
Pooja H Mehta, Jay Chhablani, Jiangxia Wang, Catherine B Meyerle
OBJECTIVE: To evaluate the frequency of central serous chorioretinopathy (CSC) in African Americans/blacks within an academic center in a predominantly African American city, as the current belief is that CSC is rare in this population. METHODS: A retrospective review of all patients' charts diagnosed with CSC at Wilmer Eye Institute/Johns Hopkins University from August 2009-August 2015 was conducted via an electronic health record search (EPIC). The charts were categorized by self-reported race and gender...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29778118/erratum
#12
(no author information available yet)
METHODS: …The systems were the Paracel/Vibex Xtra, comprising riboflavin 0.25% solution containing TRIS and ethylenediaminetetraacetic acid and an isotonic solution of riboflavin 0.25%, (Group 1) and the CXLO system (Group 2)…. RESULTS: The mean riboflavin fluorescence intensity grades in Group 2 (4 eyes) were 3.8, 4.8, and 4.8 at 10, 15, and 20 minutes, respectively. The mean grades in Group 1 (3 eyes) were 2.0, 2.3, and 2.0, respectively. The riboflavin distribution was uniform in Group 2 but not in Group 1...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29778108/rotation-of-a-toric-intraocular-lens-from-neodymium-yag-laser-posterior-capsulotomy
#13
Clemens Kaindlstorfer, Mario Kneifl, Peter Reinelt, Ulrich Schönherr
A 77-year-old man had cataract surgery in the left eye in March 2017. A toric intraocular lens (IOL) was implanted because of astigmatism. The postoperative meridian of the IOL was located nearly exactly in the planned meridian, which was controlled 1 week later with ray-tracing aberrometry (iTrace) and the smartphone application Axis Assistant. The referring ophthalmologist proceeded directly with a neodymium:YAG (Nd:YAG) laser posterior capsulotomy in his own office, after which the meridian of the implanted toric IOL was rotated more than 115 degrees...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29778107/photorefractive-intrastromal-corneal-crosslinking-for-treatment-of-myopic-refractive-error-findings-from-12-month-prospective-study-using-an-epithelium-off-protocol
#14
Matthias Elling, Inga Kersten-Gomez, H Burkhard Dick
PURPOSE: To assess the long-term effectiveness and safety of photorefractive intrastromal corneal crosslinking (CXL) in patients with low myopia. SETTING: Ruhr University Eye Hospital, Bochum, Germany. DESIGN: Prospective case series. METHODS: Healthy eyes with myopia were treated with photorefractive intrastromal CXL using the Mosaic System. Riboflavin 0.1% solution (VibeX Rapid) was topically administered, followed by 365 nm ultraviolet-A (30 mW/cm2 ) irradiance...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29778070/high-intensity-binge-drinking-is-associated-with-alterations-in-spontaneous-neural-oscillations-in-young-adults
#15
Rifqi O Affan, Siyuan Huang, Stephen M Cruz, Lee A Holcomb, Edward Nguyen, Ksenija Marinkovic
Heavy episodic alcohol consumption (also termed binge drinking) contributes to a wide range of health and cognitive deficits, but the associated brain-based indices are poorly understood. The current study used electroencephalography (EEG) to examine spontaneous neural oscillations in young adults as a function of quantity, frequency, and the pattern of their alcohol consumption. Sixty-one young adults (23.4 ± 3.4 years of age) were assigned to binge drinking (BD) and light drinking (LD) groups that were equated on gender, race/ethnic identity, age, educational background, and family history of alcoholism...
January 8, 2018: Alcohol
https://www.readbyqxmd.com/read/29777984/lc-ms-analysis-to-determine-the-biodistribution-of-a-polymer-coated-ilomastat-ocular-implant
#16
Abeer H A Mohamed-Ahmed, Alastair Lockwood, Hala Fadda, Shivam Madaan, Peng T Khaw, Steve Brocchini, Kersti Karu
Ilomastat is a matrix metalloproteinase inhibitor (MMPi) that has shown the potential to inhibit scarring (fibrosis) by mediating healing after injury or surgery. A long lasting ocular implantable pharmaceutical formulation of ilomastat is being developed to mediate the healing process to prevent scarring after glaucoma filtration surgery. The ilomastat implant was coated with water permeable and biocompatible phosphoryl choline polymer (PC1059) displayed extended slow release of ilomastat in vitro and in vivo...
May 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29777883/atypical-presentation-of-giant-aneurysm-in-a-pediatric-patient-with-duane-syndrome
#17
Chao-Hung Kuo, Lynn B McGrath, Joseph A Carnevale, Neena I Marupudi, Jeffery G Ojemann, Richard G Ellenbogen, Anthony C Wang
BACKGROUND: Duane syndrome is a congenital eye movement disorder characterized by congenital malformation of the abducens nucleus. Thrombogenic conditions during development may lead to vascular anomalies in Duane syndrome, however, the presence of a giant aneurysm in this patient population is a rarely documented phenomenon. CASE DESCRIPTION: We reported a case of a large cerebral aneurysm in a pediatric patient with Duane syndrome, and performed a review of the literatures to identify other potential cases and associations...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777869/subconjunctival-dendrimer-drug-therapy-for-the-treatment-of-dry-eye-in-rabbits-with-induced-autoimmune-dacryoadenitis
#18
Hui Lin, Ying Liu, Siva P Kambhampati, Chih-Chien Hsu, Rangaramanujam M Kannan, Samuel C Yiu
PURPOSE: To investigate the efficacy of a single subconjunctival injection of dendrimer-dexamethasone to treat dry eye in a rabbit model of induced autoimmune dacryoadenitis (AID). METHOD: Dendrimer biodistribution after subconjuntival injection in AID animals was evaluated using Cy5-labelled dendrimer (D-Cy5) and confocal microscopy. Diseased animals were treated with free dexamethasone (Free-Dex), dendrimer-dexamethasone (D-Dex), or saline via a single subconjunctival injection...
May 16, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29777856/ocular-irritation-and-cyclosporine-a-distribution-in-the-eye-tissues-after-administration-of-solid-lipid-microparticles-in-the-rabbit-model
#19
Eliza Wolska, Małgorzata Sznitowska, Juliusz Chorążewicz, Oliwia Szerkus, Aleksandra Radwańska, Michał J Markuszewski, Roman Kaliszan, Krystyna Raczyńska
The aim of this study was to investigate the in vivo effect of Solid Lipid Microparticles (SLM), proposed for topical ocular administration of cyclosporine, on the rabbit eye. SLM carrier is an aqueous dispersion of lipid microparticles (20% w/w) with a size up to 15 μm. Cyclosporine was dissolved in the formulation in the concentration of 0.5 or 2.0% (w/w). Ocular tolerance of microsphere dispersion was assessed in rabbit model by the Draize eye test (SLM was compared with emulsion and oily solution), and cyclosporine distribution in ocular tissues was evaluated after multiple application of tested formulations (SLM dispersions, emulsions and oily solution) for 7 days...
May 16, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29777757/stem-cell-based-retina-models
#20
Kevin Achberger, Jasmin C Haderspeck, Alexander Kleger, Stefan Liebau
From the early days of cell biological research, the eye-especially the retina-has evoked broad interest among scientists. The retina has since been thoroughly investigated and numerous models have been exploited to shed light on its development, morphology, and function. Apart from various animal models and human clinical and anatomical research, stem cell-based models of animal and human cells of origin have entered the field, especially during the last decade. Despite the observation that the retina of different species comprises endogenous stem cells, most stem cell-related research in the human retina is now based on pluripotent stem cell models...
May 16, 2018: Advanced Drug Delivery Reviews
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