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https://www.readbyqxmd.com/read/27864240/new-horizons-in-orthostatic-hypotension
#1
REVIEW
James Frith, Steve W Parry
BACKGROUND: orthostatic hypotension (OH) is a common disabling condition associated with increased morbidity and mortality. Much of the evidence available is derived from younger populations with chronic neurological disease leading to uncertainty for the diagnosis and management of older people. OBJECTIVE: to provide an overview of recent and emerging evidence for the diagnosis, management and prognosis of OH in older persons. METHODS: a narrative review of recent studies, emerging therapies and relevant regulatory updates...
November 17, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27662327/prevalence-and-prescribed-treatments-of-orthostatic-hypotension-in-institutionalized-patients-with-parkinson-s-disease
#2
Alaj Hommel, M J Faber, N J Weerkamp, J G van Dijk, B R Bloem, R T Koopmans
BACKGROUND: Orthostatic hypotension (OH) in Parkinson's disease (PD) is a common non-motor sign that can be hard to recognize and treat. OH prevalence and treatment in institutionalized PD-patients remains unknown. OBJECTIVE: The aim of this study was to explore the prevalence and prescribed treatments of OH in institutionalized patients with PD. METHOD: A cross-sectional study of nursing homes in the south-east of the Netherlands identified 64 residents with PD (inclusion criteria: MMSE >18)...
October 19, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27660674/therapeutic-alternatives-for-the-treatment-of-type-1-hepatorenal-syndrome-a-delphi-technique-based-consensus
#3
Juan P Arab, Juan C Claro, Juan P Arancibia, Jorge Contreras, Fernando Gómez, Cristian Muñoz, Leyla Nazal, Eric Roessler, Rodrigo Wolff, Marco Arrese, Carlos Benítez
AIM: To propose several alternatives treatment of type 1 hepatorenal syndrome (HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension. METHODS: A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature. Each expert was designated to review and answer a question. They generated draft statements for evaluation by all the experts. Additional input was obtained from medical community...
September 8, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27652229/the-drug-treatment-of-delayed-ejaculation
#4
REVIEW
Ibrahim A Abdel-Hamid, Moustafa A Elsaied, Taymour Mostafa
Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966 to February 2016, including PubMed MEDLINE, EMBASE, EBCSO Academic Search Complete, Cochrane Systematic Reviews Database, and Google Scholar using key words; delayed ejaculation, retarded ejaculation, inhibited ejaculation, drugs, treatment, or pharmacology...
August 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27639073/a-novel-sensitive-and-selective-method-of-uplc-ms-ms-for-rapid-simultaneous-determination-of-midodrine-and-its-active-metabolite-desglymidodrine-in-human-plasma-application-to-support-bioequivalence-study-in-healthy-human-volunteers
#5
Daxesh P Patel, Sneha Nair, Bhanubhai N Suhagia, Bhargav M Patel
A specific, rapid, sensitive and selective ultra-performance liquid chromatography - tandem mass spectrometry has been developed for the simultaneous determination of midodrine and desglymidodrine in human plasma. The analytes and its deuterated analogs were quantitatively extracted from 100μL of human plasma by solid phase extraction technique. Separation of analytes was achieved on the Waters Acquity UPLC BEH C18 (50×2.1mm, 1.7μm) column using acetonitrile-4.0mM ammonium formate, pH 2.5(90:10, v/v) as mobile phase...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27622998/rifaximin-and-midodrine-improve-clinical-outcome-in-refractory-ascites-including-renal-function-weight-loss-and-short-term-survival
#6
Amr S Hanafy, Ahmad M Hassaneen
BACKGROUNDS AND AIMS: The occurrence of refractory ascites in nearly 17% of patients with decompensated cirrhosis is an unresolved issue. Advanced liver disease, functional renal impairment, and vascular insensitivity to vasopressors are the main causes of its refractoriness. Therefore, the aim of this study was to evaluate the impact on diuresis, weight loss, and short-term survival if midodrine and rifaximin were added to the diuretic therapy (DT). MATERIALS AND METHODS: The study evaluated the eligibility of 650 patients with cirrhosis and refractory ascites who were selected during the period from November 2011 to May 2015...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27614145/midodrine-and-tolvaptan-in-patients-with-cirrhosis-and-refractory-or-recurrent-ascites-a-randomised-pilot-study
#7
Nitish Rai, Baljinder Singh, Akash Singh, Rajesh Vijayvergiya, Navneet Sharma, Ashish Bhalla, Virendra Singh
BACKGROUND: Splanchnic arterial vasodilatation and subsequent sodium and water retention play an important role in cirrhotic ascites. Midodrine and tolvaptan have been used separately in these patients. However, there are no reports on the use of combination of midodrine and tolvaptan in the control of ascites. The aim of this study was to evaluate the safety and efficacy of midodrine, tolvaptan and their combination in control of refractory or recurrent ascites in cirrhotics. METHODS: Fifty cirrhotic patients with refractory or recurrent ascites were randomised to receive midodrine (n=13), tolvaptan (n=12) or both (n=13) plus standard medical therapy (SMT) or SMT alone (n=12)...
September 10, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27417951/severe-hypertension-and-bradycardia-secondary-to-midodrine-overdose
#8
L Y Wong, A Wong, T Robertson, K Burns, M Roberts, G K Isbister
The objective of this case is to describe the pharmacokinetics and toxicity of midodrine in overdose. A 20 year old female ingested up to 350 mg midodrine while recovering in hospital from another overdose. She developed vomiting and severe hypertension (blood pressure [BP], 210/100 mmHg). Remarkable findings included a heart rate with a range of 43-60 beats/min, spontaneous respirations (20 breaths/min), and oxygen saturations of >95 % on FiO2 25 %, and a GS of 8. She was admitted to intensive care and had a normal non-contrast CT brain...
July 14, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27412743/-predictive-value-of-upright-blood-pressure-change-for-long-term-prognosis-of-children-with-postural-tachycardia-syndrome-treated-with-midodrine-hydrochloride
#9
H X Li, W J Deng, C Y Zhang, H F Jin, J B Du
OBJECTIVE: To explore the predictive value of upright blood pressure change for long-term prognosis of children with postural tachycardia syndrome (POTS) treated with midodrine hydrochloride. METHOD: A total of 90 children (male 41, female 49) were enrolled in this study. Their mean age was (11.8±2.7) years. They were diagnosed as POTS in Peking University First Hospital from 2005 to 2011. According to the upright change of blood pressure at the first visit, they were divided into two groups, effective group (n=55) and ineffective group(n=35)...
July 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27372462/clinical-benefit-of-midodrine-hydrochloride-in-symptomatic-orthostatic-hypotension-a-phase-4-double-blind-placebo-controlled-randomized-tilt-table-study
#10
William Smith, Hong Wan, David Much, Antoine G Robinson, Patrick Martin
OBJECTIVE: Midodrine hydrochloride is a short-acting pressor agent that raises blood pressure in the upright position in patients with orthostatic hypotension. The US Food and Drug Administration's Subpart H approval, under which midodrine was initially approved, requires post-marketing studies to confirm midodrine's clinical benefit in this indication. The purpose of this study was to evaluate the clinical benefit of midodrine with regard to symptom response. METHODS: This was a double-blind, placebo-controlled, randomized, crossover, multicenter study (NCT01518946)...
August 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27348915/-clinical-research-of-needle-pricking-therapy-for-functional-retrograde-ejaculatioin
#11
RANDOMIZED CONTROLLED TRIAL
Dong Cheng, Lei Hu, Feng Xian, Jian Zhong, Yuejuan Zhang, Gangwei Wang, Jiyuan Ma, Hao Xu
OBJECTIVE: To observe the clinical effects of needle-pricking therapy, a newly medical and minimally invasive technique, for functional retrograde ejaculation and to explore its mechanism. Methods Thirty-six patients with functional retrograde ejaculation were randomly divided into an observation group(19 cases) and a control group(17 cases) In the observation group,needle-pricking therapy was used at Guanyuan(CV 4) and bilateral sacral plexus nerve,lumbar 1 nerve and greater occipital nerve stimulating points,once a week...
February 2016: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/27271310/efficacy-of-servo-controlled-splanchnic-venous-compression-in-the-treatment-of-orthostatic-hypotension-a-randomized-comparison-with-midodrine
#12
Luis E Okamoto, André Diedrich, Franz J Baudenbacher, René Harder, Jonathan S Whitfield, Fahad Iqbal, Alfredo Gamboa, Cyndya A Shibao, Bonnie K Black, Satish R Raj, David Robertson, Italo Biaggioni
UNLABELLED: Splanchnic venous pooling is a major hemodynamic determinant of orthostatic hypotension, but is not specifically targeted by pressor agents, the mainstay of treatment. We developed an automated inflatable abdominal binder that provides sustained servo-controlled venous compression (40 mm Hg) and can be activated only on standing. We tested the efficacy of this device against placebo and compared it to midodrine in 19 autonomic failure patients randomized to receive either placebo, midodrine (2...
August 2016: Hypertension
https://www.readbyqxmd.com/read/27173783/midodrine-for-severe-orthostatic-hypotension
#13
(no author information available yet)
Midodrine (Bramox-Brancaster Pharma Limited) was authorised in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA) in March 2015 for "the treatment of severe orthostatic hypotension due to autonomic dysfunction in adults when corrective factors have been ruled out and other forms of treatment are inadequate".(1) Previously, midodrine had only been available in the UK as an unlicensed product used on a named-patient basis. It is the first drug to be licensed in the UK for the treatment of orthostatic hypotension...
May 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27169082/effect-of-alpha-1-adrenergic-agonist-midodrine-for-the-management-of-long-standing-neurogenic-shock-in-patient-with-cervical-spinal-cord-injury-a-case-report
#14
Taikwan Kim, Cheol Su Jwa
We report a rare case of a 71-year-old male patient who had suffered from long-lasting neurogenic shock for 13 weeks after cervical spinal cord injury (SCI) caused by a bicycle accident. The neurogenic shock was resolved dramatically 2 weeks after the administration of alpha-1-adrenergic agonist, midodrine hydrochloride. In usual cases, neurogenic shock tends to improve between 2 and 6 weeks after SCI; however, in a few cases, the shock lasts for several months. In our case, spinal shock lasted for 13 weeks and exhibited very sensitive decline of blood pressure for even a slight decrease of dopamine despite recovered bulbospongiosus reflex...
October 2015: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27138287/pathophysiology-and-treatment-of-orthostatic-hypotension-in-parkinsonian-disorders
#15
REVIEW
Dong In Sinn, Christopher H Gibbons
Orthostatic hypotension (OH) is defined as a sustained pathological reduction in blood pressure within 3 min after orthostatic stress such as tilt-table testing or active standing. Non-neurogenic OH is caused by either decreased cardiac output or impaired vasoconstriction without a primary autonomic disorder whereas neurogenic OH results from inadequate release of norepinephrine in the vasomotor sympathetic system. Once non-neurogenic causes of OH such as medications and cardiac problems are ruled out, neurogenic OH can be considered...
June 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27111626/effect-of-selective-prostaglandin-e2-ep2-receptor-agonist-cp-533-536-on-voiding-efficiency-in-rats-with-midodrine-induced-functional-urethral-obstruction
#16
Ryoko Kurihara, Katsunori Imazumi, Hajime Takamatsu, Kenichiro Ishizu, Taiji Yoshino, Noriyuki Masuda
OBJECTIVES: We investigated the effect of the selective prostaglandin E2 EP2 receptor agonist CP-533,536 on voiding efficiency in rats with midodrine-induced functional urethral obstruction. METHODS: The effect of CP-533,536 (0.03-0.3 mg/kg, intravenous [i.v.]) on urethral perfusion pressure (UPP) was investigated in anesthetized rats pre-treated with midodrine (1 mg/kg, i.v.), which forms an active metabolite that acts as an α1 -adrenoceptor agonist. The effect of CP-533,536 (0...
May 2016: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/27097354/effect-of-different-therapeutic-modalities-on-systemic-renal-and-hepatic-hemodynamics-and-short-term-outcomes-in-cirrhotic-patients-with-spontaneous-bacterial-peritonitis
#17
Tary A Salman, Ahmed M Edrees, Hala H El-Said, Osama L El-Abd, Gasser I El-Azab
BACKGROUND: Spontaneous bacterial peritonitis (SBP) is a major risk factor for hepatorenal syndrome. Albumin infusion has been shown to prevent renal impairment and reduce mortality in SBP. The study aimed to compare the effect of different therapeutic modalities on hemodynamics and short clinical outcomes in high-risk patients with SBP. METHODS: Two hundred cirrhotic patients with SBP and bilirubin greater than 4 mg[Fraction Slash]dl or creatinine more than 1 mg[Fraction Slash]dl were enrolled...
July 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27096702/diagnosing-and-treating-renal-disease-in-cirrhotic-patients
#18
Florence Wong
Renal dysfunction in cirrhosis is mostly related to the development of acute kidney injury (AKI), precipitated by either an acute disturbance of hemodynamics, or acute structural damage to the kidneys. The incidence of chronic renal failure is rising, due to increasing prevalence of conditions such as diabetes, viral hepatitis, which can be associated with renal damage. AKI is defined as a rise in serum creatinine of 0.3 mg/dL in <48 hours or by 50% from baseline within the past 3 months without setting a threshold for the final serum creatinine...
September 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27090347/novel-role-of-midodrine-in-pulmonary-hypertension-in-liver-transplant-candidates
#19
LETTER
Priyanka Rajaram, James Spivey, Micah Fisher
No abstract text is available yet for this article.
July 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27063094/drugs-with-potential-cardiac-adverse-effects-retrospective-study-in-a-large-cohort-of-parkinsonian-patients
#20
A Heranval, R Lefaucheur, D Fetter, A Rouillé, F Le Goff, D Maltête
INTRODUCTION/OBJECTIVE: Drugs with potential cardiac adverse effects are commonly prescribed in Parkinson's disease (PD). To describe demographic and clinical characteristics in a group of PD patients with cardiac events and to evaluate risk factors. PATIENTS AND METHODS: We sampled 506 consecutive PD patients (211 women/295 men), median age 68.3±10.6 years (range 36-95) and median disease duration 11.2±6.5 years (range 1-49). Medications with potential cardiac effects, i...
April 2016: Revue Neurologique
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