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https://www.readbyqxmd.com/read/29450813/memory-rehabilitation-in-patients-with-epilepsy-a-systematic-review
#1
REVIEW
Samantha Joplin, Elizabeth Stewart, Michael Gascoigne, Suncica Lah
Memory failure is a common clinical concern of patients with epilepsy and is associated with significant functional impairments. Thus, memory rehabilitation is of critical clinical importance. In this article, we aimed to systematically evaluate the efficacy of memory rehabilitation in patients with epilepsy. The Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) was used to guide searches, extraction and reporting of data in this review. PsycINFO, Medline and PsychBITE searches yielded 95 studies...
February 15, 2018: Neuropsychology Review
https://www.readbyqxmd.com/read/29449490/dentate-gyrus-mossy-cells-control-spontaneous-convulsive-seizures-and-spatial-memory
#2
Anh D Bui, Theresa M Nguyen, Charles Limouse, Hannah K Kim, Gergely G Szabo, Sylwia Felong, Mattia Maroso, Ivan Soltesz
Temporal lobe epilepsy (TLE) is characterized by debilitating, recurring seizures and an increased risk for cognitive deficits. Mossy cells (MCs) are key neurons in the hippocampal excitatory circuit, and the partial loss of MCs is a major hallmark of TLE. We investigated how MCs contribute to spontaneous ictal activity and to spatial contextual memory in a mouse model of TLE with hippocampal sclerosis, using a combination of optogenetic, electrophysiological, and behavioral approaches. In chronically epileptic mice, real-time optogenetic modulation of MCs during spontaneous hippocampal seizures controlled the progression of activity from an electrographic to convulsive seizure...
February 16, 2018: Science
https://www.readbyqxmd.com/read/29420859/amygdala-stimulation-induced-apnea-is-attention-and-nasal-breathing-dependent
#3
William P Nobis, Stephen Schuele, Jessica W Templer, Guangyu Zhou, Gregory Lane, Joshua M Rosenow, Christina Zelano
OBJECTIVE: Evidence suggests disordered breathing is critically involved in Sudden unexplained death in epilepsy (SUDEP). To that end, evaluating structures that are activated by seizures and can activate brain regions that produce cardiorespiratory changes can further our understanding of the pathophysiology of SUDEP. Prior preclinical studies have shown that electrical stimulation of the human amygdala induces apnea, suggesting a role for the amygdala in controlling respiration. In this study, we aimed to both confirm these findings in a larger group of patients with intractable temporal lobe epilepsy (TLE) and also further explore the anatomical and cognitive properties of this effect...
February 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29414546/unique-and-shared-areas-of-cognitive-function-in-children-with-intractable-frontal-or-temporal-lobe-epilepsy
#4
Nicole Law, Elysa Widjaja, Mary Lou Smith
OBJECTIVE: Previous findings have been mixed in terms of identifying a distinct pattern of neuropsychological deficits in children with frontal lobe epilepsy (FLE) and in those with temporal lobe epilepsy (TLE). The current study investigated the neuropsychological similarities and differences across these two pediatric medically intractable localization-related epilepsies. METHOD: Thirty-eight children with FLE, 20 children with TLE, and 40 healthy children (HC) participated in this study...
January 25, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29376090/cognitive-impairment-in-epilepsy-the-role-of-reduced-network-flexibility
#5
Chris Tailby, Magdalena A Kowalczyk, Graeme D Jackson
Objective: The dominant model of cognitive impairment in focal epilepsy has emphasised structural bases for cognitive deficits. Current theories of cognition in the healthy brain emphasise the importance of the reweighting of brain network interactions in support of task performance. Here, we explore the hypothesis that cognitive deficits in epilepsy arise through abnormalities of dynamic functional network interactions. Method: We studied 19 healthy controls and 37 temporal lobe epilepsy (TLE) patients, using a behavioural measure of verbal fluency (the Controlled Oral Word Association Test) and an fMRI verbal fluency paradigm (Orthographic Lexical Retrieval)...
January 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29351584/the-roles-of-left-versus-right-anterior-temporal-lobes-in-semantic-memory-a-neuropsychological-comparison-of-postsurgical-temporal-lobe-epilepsy-patients
#6
Grace E Rice, Helen Caswell, Perry Moore, Paul Hoffman, Matthew A Lambon Ralph
The presence and degree of specialization between the anterior temporal lobes (ATLs) is a key issue in debates about the neural architecture of semantic memory. Here, we comprehensively assessed multiple aspects of semantic cognition in a large group of postsurgical temporal lobe epilepsy (TLE) patients with left versus right anterior temporal lobectomy (n = 40). Both subgroups showed deficits in expressive and receptive verbal semantic tasks, word and object recognition, naming and recognition of famous faces and perception of faces and emotions...
January 17, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29331847/longitudinal-hippocampal-and-extra-hippocampal-microstructural-and-macrostructural-changes-following-temporal-lobe-epilepsy-surgery
#7
Cameron A Elliott, Donald W Gross, B Matt Wheatley, Christian Beaulieu, Tejas Sankar
OBJECTIVES: 1) Characterize the evolution of microstructural changes in the contralateral, non-operated hippocampus-using longitudinal diffusion tensor imaging (DTI)-following surgery for temporal lobe epilepsy (TLE). 2) Characterize the downstream extra-hippocampal volumetric changes of the fornix and mammillary bodies after TLE surgery. 3) Examine the relationship between these measures and seizure/cognitive outcome. METHODS: Serial structural and DTI brain MRI scans were collected in 25 TLE patients pre- and post-surgery (anterior temporal lobectomy, ATL - 13; selective amygdalohippocampectomy, SelAH - 12) and in 12 healthy controls...
January 6, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29331082/mechanistic-target-of-rapamycin-complex-1-and-2-in-human-temporal-lobe-epilepsy
#8
Delia M Talos, Leah M Jacobs, Sarah Gourmaud, Carlos A Coto, Hongyu Sun, Kuei-Cheng Lim, Timothy H Lucas, Kathryn A Davis, Maria Martinez-Lage, Frances E Jensen
OBJECTIVE: Temporal lobe epilepsy (TLE) is a chronic epilepsy syndrome defined by seizures and progressive neurological disabilities, including cognitive impairments, anxiety and depression. Here, human TLE specimens were investigated focusing on the mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) and Complex 2 (mTORC2) activities in the brain, as both pathways may represent unique targets for treatment. METHODS: Surgically resected hippocampal and temporal lobe samples from therapy-resistant TLE patients were analyzed by Western blotting to quantify the expression of established mTORC1 and mTORC2 activity markers and upstream or downstream signaling pathways involving the two complexes...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29288503/neurodegenerative-processes-in-temporal-lobe-epilepsy-with-hippocampal-sclerosis-clinical-pathological-and-neuroimaging-evidence
#9
X Y Tai, B Bernhardt, M Thom, P Thompson, S Baxendale, M Koepp, N Bernasconi
Cognitive decline is increasingly described as a co-morbidity of temporal lobe epilepsy (TLE). Mechanisms underlying cognitive impairment are not fully understood despite examining clinical factors, such as seizure frequency, and cellular mechanisms of excitotoxicity. We review the neuropsychometry evidence for progressive cognitive decline and examine the pathology and neuroimaging evidence supporting a neurodegenerative process in hippocampal sclerosis (HS)-related TLE. Accelerated cognitive decline is described in groups of adult HS-related TLE patients...
December 30, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29287217/association-of-white-matter-diffusion-characteristics-and-cognitive-deficits-in-temporal-lobe-epilepsy
#10
Raúl Rodríguez-Cruces, Leticia Velázquez-Pérez, Ildefonso Rodríguez-Leyva, Ana Luisa Velasco, David Trejo-Martínez, Héctor Manuel Barragán-Campos, Vicente Camacho-Téllez, Luis Concha
OBJECTIVE: The purpose of this study was to evaluate the relation between cognitive performance and white matter (WM) integrity in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS). METHODS: We included 26 patients with TLE (10 right, 16 left onset) as well as 24 healthy controls matched for age, gender, and years of education. In addition to quantitative hippocampal volume and transverse relaxation (T2) evaluation, whole-brain WM was analyzed using fractional anisotropy (FA) maps, derived from the diffusion tensor model...
December 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29205291/interactive-effects-of-seizure-frequency-and-lateralization-on-intratemporal-effective-connectivity-in-temporal-lobe-epilepsy
#11
Chang-Hyun Park, Yun Seo Choi, Hyeon Jin Kim, Hwa-Kyung Chung, A-Reum Jung, Jeong Hyun Yoo, Hyang Woon Lee
OBJECTIVE: Patients with temporal lobe epilepsy (TLE) show brain connectivity changes in association with cognitive impairment. Seizure frequency and lateralization are 2 important clinical factors that characterize epileptic seizures. In this study, we sought to examine an interactive effect of the 2 seizure factors on intratemporal effective connectivity based on resting-state functional magnetic resonance imaging (rsfMRI) in patients with TLE. METHODS: For rsfMRI data acquired from 48 TLE patients and 45 healthy controls, we applied stochastic dynamical causal modeling to infer effective connectivity between 3 medial temporal lobe (MTL) regions, including the hippocampus (Hipp), parahippocampal gyrus (PHG), and amygdala (Amyg), ipsilateral to the seizure focus...
January 2018: Epilepsia
https://www.readbyqxmd.com/read/29186698/effect-of-atorvastatin-on-behavioral-alterations-and-neuroinflammation-during-epileptogenesis
#12
Clarissa Vasconcelos de Oliveira, Jéssica Grigoletto, Julia Marion Canzian, Marta Maria Medeiros Frescura Duarte, Thiago Duarte, Ana Flávia Furian, Mauro Schneider Oliveira
Temporal lobe epilepsy (TLE) is the most frequent and medically refractory type of epilepsy in humans. In addition to seizures, patients with TLE suffer from behavioral alterations and cognitive deficits. Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of potential targets for antiepileptogenic therapies. Clinical and experimental evidence suggests that inflammatory processes in the brain may critically contribute to epileptogenesis...
November 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29180982/resveratrol-for-easing-status-epilepticus-induced-brain-injury-inflammation-epileptogenesis-and-cognitive-and-memory-dysfunction-are-we-there-yet
#13
REVIEW
Olagide W Castro, Dinesh Upadhya, Maheedhar Kodali, Ashok K Shetty
Status epilepticus (SE) is a medical emergency exemplified by self-sustaining, unceasing seizures or swiftly recurring seizure events with no recovery between seizures. The early phase after SE event is associated with neurodegeneration, neuroinflammation, and abnormal neurogenesis in the hippocampus though the extent of these changes depends on the severity and duration of seizures. In many instances, over a period, the initial precipitating injury caused by SE leads to temporal lobe epilepsy (TLE), typified by spontaneous recurrent seizures, cognitive, memory and mood impairments associated with chronic inflammation, reduced neurogenesis, abnormal synaptic reorganization, and multiple molecular changes in the hippocampus...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29099058/diverse-effects-of-an-acetylcholinesterase-inhibitor-donepezil-on-hippocampal-neuronal-death-after-pilocarpine-induced-seizure
#14
Jeong Hyun Jeong, Bo Young Choi, A Ra Kho, Song Hee Lee, Dae Ki Hong, Sang Hwon Lee, Sang Yup Lee, Hong Ki Song, Hui Chul Choi, Sang Won Suh
Epileptic seizures are short episodes of abnormal brain electrical activity. Many survivors of severe epilepsy display delayed neuronal death and permanent cognitive impairment. Donepezil is an acetylcholinesterase inhibitor and is an effective treatment agent for Alzheimer's disease. However, the role of donepezil in seizure-induced hippocampal injury remains untested. Temporal lobe epilepsy (TLE) was induced by intraperitoneal injection of pilocarpine (25 mg/kg). Donepezil (2.5 mg/kg/day) was administered by gavage in three different settings: (1) pretreatment for three days before the seizure; (2) for one week immediately after the seizure; and (3) for three weeks from three weeks after the seizure...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29074125/status-epilepticus-triggers-long-lasting-activation-of-complement-c1q-c3-signaling-in-the-hippocampus-that-correlates-with-seizure-frequency-in-experimental-epilepsy
#15
Nicole D Schartz, Season K Wyatt-Johnson, Lauren R Price, Samantha A Colin, Amy L Brewster
Status epilepticus (SE) triggers a myriad of neurological alterations that include unprovoked seizures, temporal lobe epilepsy (TLE), and cognitive deficits. Although SE-induced loss of hippocampal dendritic structures and synaptic remodeling are often associated with this pathophysiology, the underlying mechanisms remain elusive. Recent evidence points to the classical complement pathway as a potential mechanism. Signaling through the complement protein C1q to C3, which is cleaved into smaller biologically active fragments including C3b and iC3b, contributes to the elimination of synaptic structures in the normal developing brain and in models of neurodegenerative disorders...
October 23, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29060837/transient-reduction-in-theta-power-caused-by-interictal-spikes-in-human-temporal-lobe-epilepsy
#16
Manling Ge, Jundan Guo, Yangyang Xing, Zhiguo Feng, Weide Lu, Xinxin Ma, Yuehua Geng, Xin Zhang
The inhibitory impacts of spikes on LFP theta rhythms(4-8Hz) are investigated around sporadic spikes(SSs) based on intracerebral EEG of 4 REM sleep patients with temporal lobe epilepsy(TLE) under the pre-surgical monitoring. Sequential interictal spikes in both genesis area and extended propagation pathway are collected, that, SSs genesis only in anterior hippocampus(aH)(possible propagation pathway in Entorhinal cortex(EC)), only in EC(possible propagation pathway in aH), and in both aH and EC synchronously...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29035369/epigenetic-suppression-of-hippocampal-calbindin-d28k-by-%C3%AE-fosb-drives-seizure-related-cognitive-deficits
#17
Jason C You, Kavitha Muralidharan, Jin W Park, Iraklis Petrof, Mark S Pyfer, Brian F Corbett, John J LaFrancois, Yi Zheng, Xiaohong Zhang, Carrie A Mohila, Daniel Yoshor, Robert A Rissman, Eric J Nestler, Helen E Scharfman, Jeannie Chin
The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognition, but its expression is markedly decreased in various neurological disorders associated with epileptiform activity and seizures. In Alzheimer's disease (AD) and epilepsy, both of which are accompanied by recurrent seizures, the severity of cognitive deficits reflects the degree of calbindin reduction in the hippocampal dentate gyrus (DG). However, despite the importance of calbindin in both neuronal physiology and pathology, the regulatory mechanisms that control its expression in the hippocampus are poorly understood...
November 2017: Nature Medicine
https://www.readbyqxmd.com/read/28991719/neuroimaging-and-cognitive-functions-in-temporal-lobe-epilepsy-a-review-of-the-literature
#18
REVIEW
Cettina Allone, Viviana Lo Buono, Francesco Corallo, Laura Rosa Pisani, Patrizia Pollicino, Placido Bramanti, Silvia Marino
Temporal lobe epilepsy (TLE) is the most common form of refractory focal epilepsy. Neuroimaging researches have demonstrated structural abnormalities in several cerebral regions. Cognitive impairment has been frequently described as a potential comorbidity of long-term TLE. This review investigated the state of research regarding neuropsychological impairment and neuroimaging studies in TLE patients. Studies were found on PubMed and Web of Sciences databases, 412 publications were selected: only 20 articles met search criteria...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28931428/personalized-predictive-modeling-for-patients-with-alzheimer-s-disease-using-an-extension-of-sullivan-s-life-table-model
#19
Eric Stallard, Bruce Kinosian, Yaakov Stern
BACKGROUND: Alzheimer's disease (AD) progression varies substantially among patients, hindering calculation of residual total life expectancy (TLE) and its decomposition into disability-free life expectancy (DFLE) and disabled life expectancy (DLE) for individual patients with AD. The objective of the present study was to assess the accuracy of a new synthesis of Sullivan's life table (SLT) and longitudinal Grade of Membership (L-GoM) models that estimates individualized TLEs, DFLEs, and DLEs for patients with AD...
September 20, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28863828/quantitative-and-qualitative-analysis-of-semantic-verbal-fluency-in-patients-with-temporal-lobe-epilepsy
#20
A G Jaimes-Bautista, M Rodríguez-Camacho, I E Martínez-Juárez, Y Rodríguez-Agudelo
INTRODUCTION: Patients with temporal lobe epilepsy (TLE) perform poorly on semantic verbal fluency (SVF) tasks. Completing these tasks successfully involves multiple cognitive processes simultaneously. Therefore, quantitative analysis of SVF (number of correct words in one minute), conducted in most studies, has been found to be insufficient to identify cognitive dysfunction underlying SVF difficulties in TLE. OBJECTIVES: To determine whether a sample of patients with TLE had SVF difficulties compared with a control group (CG), and to identify the cognitive components associated with SVF difficulties using quantitative and qualitative analysis...
August 29, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
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