keyword
https://read.qxmd.com/read/37881572/low-dopamine-d2-receptor-expression-drives-gene-networks-related-to-gaba-camp-growth-and-neuroinflammation-in-striatal-indirect-pathway-neurons
#21
JOURNAL ARTICLE
Lucia Guerri, Lauren K Dobbs, Daniel A da Silva E Silva, Allen Meyers, Aaron Ge, Lea Lecaj, Caroline Djakuduel, Damien Islek, Dionisio Hipolito, Abdiel Badillo Martinez, Pei-Hong Shen, Cheryl A Marietta, Susanna P Garamszegi, Enrico Capobianco, Zhijie Jiang, Melanie Schwandt, Deborah C Mash, Veronica A Alvarez, David Goldman
BACKGROUND: A salient effect of addictive drugs is to hijack the dopamine reward system, an evolutionarily conserved driver of goal-directed behavior and learning. Reduced dopamine type 2 receptor availability in the striatum is an important pathophysiological mechanism for addiction that is both consequential and causal for other molecular, cellular, and neuronal network differences etiologic for this disorder. Here, we sought to identify gene expression changes attributable to innate low expression of the Drd2 gene in the striatum and specific to striatal indirect medium spiny neurons (iMSNs)...
October 2023: Biol Psychiatry Glob Open Sci
https://read.qxmd.com/read/37878798/recommendation-for%C3%A2-long-term-management-of%C3%A2-adult-attention-deficit-hyperactivity-disorder-in%C3%A2-military-populations-veterans-and%C3%A2-dependents-a-narrative-review
#22
JOURNAL ARTICLE
Derek J Baughman, Crista M Watson, Jonathan W Beich, May N Joresa Herboso, Liana K Cuttie, Ari-Beth C Marlyne
INTRODUCTION: In addition to the higher burden of mental health disease in the military, there is a compounding antecedent association between behavioral health comorbidities and the treatment of attention-deficit/hyperactivity disorder (ADHD) in this population. Despite the low prevalence of new-onset ADHD in adults globally, the rate of stimulant (i.e., amphetamines) prescription is increasing. Stimulants can exacerbate mental health disease (often masquerading as ADHD symptomatology), precluding optimal treatment of the underlying etiology and imposing unnecessary dangerous side effects...
October 25, 2023: Military Medicine
https://read.qxmd.com/read/37791997/matrix-metalloproteinase-9-a-magic-drug-target-in-neuropsychiatry
#23
REVIEW
Krzysztof T Kaczmarek, Karolina Protokowicz, Leszek Kaczmarek
Neuropsychiatric conditions represent a major medical and societal challenge. The etiology of these conditions is very complex and combines genetic and environmental factors. The latter, for example, excessive maternal or early postnatal inflammation, as well as various forms of psychotrauma, often act as triggers leading to mental illness after a prolonged latent period (sometimes years). Matrix metalloproteinase-9 (MMP-9) is an extracellularly and extrasynaptic operating protease that is markedly activated in response to the aforementioned environmental insults...
October 4, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/37736438/mirtazapine-a-one-stop-strategy-for-treatment-of-opioid-withdrawal-symptoms
#24
REVIEW
Elisha Lalani, Raakhi Menon, Mariam A Mufti, Cecil Kumfa, Mukaila Raji
Public health efforts to reduce the opioid overdose epidemic and treat opioid use disorder (OUD) have met with challenges associated with current non-standardized approaches to managing opioid withdrawal symptoms, such as itching, jitteriness, anxiety, depression, craving, vomiting, diarrhea, insomnia, and anorexia. These symptoms pose substantial obstacles to the safe initiation of medications for OUD, maintenance of long-term sobriety, and prevention of relapse. In clinical practice, multiple medications (polypharmacy) are prescribed to manage these withdrawal symptoms, including ondansetron and promethazine for vomiting and nausea, loperamide and Lomotil for diarrhea, hydroxyzine and doxepin for pruritus, benzodiazepines, the Z-drugs, and melatonin for insomnia, and benzos, tricyclic antidepressants (TCAs), and various serotonergic agents for anxiety...
August 2023: Curēus
https://read.qxmd.com/read/37680452/editorial-deepening-our-understanding-of-the-etiology-of-gaming-disorder-and-gambling-disorder
#25
EDITORIAL
Jiang Long, Chang Qi, Natacha Carragher
No abstract text is available yet for this article.
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37614061/impulsivity-and-reactive-proactive-aggression-as-mechanisms-of-alcohol-related-sexual-intimate-partner-violence-perpetration-among-romantic-partners
#26
JOURNAL ARTICLE
Daniel W Oesterle, Christopher I Eckhardt, Dominic J Parrott
Background: Sexual intimate partner violence (S-IPV) commonly occurs within the contexts of committed romantic relationshops. Prior research has demonstrated the existence of a robust link between alcohol use and S-IPV. Despite this, few research studies have explored the etiological underpinnings of alcohol-related S-IPV perpetration, specifically. The present study examines the role of several key factors (i.e., problematic drinking, negative and positive urgency, proactive and reactive aggression) on S-IPV perpetration...
August 23, 2023: Substance Use & Misuse
https://read.qxmd.com/read/37610629/the-role-of-bdnf-and-npy-levels-effects-of-behavioral-systems-and-emotion-regulation-on-internet-addiction-in-adolescents
#27
JOURNAL ARTICLE
Esra Demirci, Neslihan Tastepe, Sevgi Ozmen, Eser Kilic
Internet addiction (IA), one of the behavioral addictions, is also related to impulsivity. Although studies on its etiology and risks continue, the number of studies is limited. In this study, we aimed to assess the roles of behavioral systems, emotional regulation (ER), and impulsivity in the development of IA in adolescents and also to assess the relationship between all these clinical parameters and brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY). Forty-two adolescents with IA and 30 healthy controls (ages 12 -17) were included in the study...
August 23, 2023: Psychiatric Quarterly
https://read.qxmd.com/read/37556044/cebranopadol-for-the-treatment-of-chronic-pain
#28
REVIEW
Amber N Edinoff, Chelsi J Flanagan, Logan T Roberts, Ross M Dies, Saurabh Kataria, Eric D Jackson, Audrey J DeWitt, Danielle M Wenger, Elyse M Cornett, Adam M Kaye, Alan D Kaye
PURPOSE OF REVIEW: Regardless of the etiology, if pain persists chronically, it can detrimentally impact multiple aspects of a patient's well-being. Both physical and psychological effects are significant in many chronic pain patients. In this regard, psychological consequences can alter a patient's quality of life, functionality, and social functioning. Opioids have been the long-established gold standard for acute pain treatment in settings such as the postoperative period. An alternative to opioids in pain management has been highly sought after...
August 9, 2023: Current Pain and Headache Reports
https://read.qxmd.com/read/37551861/-don-t-you-understand-that-we-are-punishing-you-for-your-own-good-attitudes-of-women-with-substance-use-disorder-to-punitive-and-therapeutic-methods-in-closed-communities
#29
JOURNAL ARTICLE
Tomer Einat, Oshrat Ben Shoshan
The growing numbers of women with substance use disorder (SUD) and the resulting establishment of dedicated treatment and rehabilitation services have spawned a rich literature on the etiology of addiction among women, their therapy needs and the effectiveness of the treatments they receive. Nevertheless, very few studies have examined the punitive methods applied to women with SUD as part of their treatment. This study examines the positions of thirteen Israeli women with SUD regarding punishments meted out in closed therapeutic communities (TCs), and their experienced short- and long-term implications...
August 8, 2023: International Journal of Offender Therapy and Comparative Criminology
https://read.qxmd.com/read/37539047/prevention-and-intervention-with-young-people-as-a-critical-public-health-strategy-to-curtail-the-opioid-epidemic-a-call-to-action
#30
JOURNAL ARTICLE
Carla Kmett Danielson, Jenna McCauley, Jesse Hinkley, Austin Hahn, Angela Moreland, Cristina López, Morgan Goodyear, Zack Adams, Mike McCart
Opioid use continues to represent a significant public health problem in the United States, as well as globally. The opioid epidemic has motivated advances in the effective treatment of opioid use disorder (OUD), with a particular focus on medications for OUD (MOUD), including methadone, buprenorphine, and naltrexone. Although these medications are remarkably effective, MOUD expansion initiatives alone have not been sufficient to combat the opioid epidemic. Further, critical questions remain regarding the effectiveness of these medications for individuals who initiate opioid use under age 16...
2023: Journal of Addiction Research & Therapy
https://read.qxmd.com/read/37496136/dual-role-of-exosome-in-neurodegenerative-diseases-a-review-study
#31
JOURNAL ARTICLE
Mohsen Sheykhhasan, Fatemeh Heidari, Mohsen Eslami Farsani, Maryam Azimzadeh, Naser Kalhor, Shima Ababzadeh, Reihaneh Seyedebrahimi
INTRODUCTION: Extracellular vesicles (EVs) are one of the crucial means of intercellular communication, which takes many different forms. They are heterogeneous, secreted by a range of cell types, and can be generally classified into microvesicles and exosomes depending on their location and function. Exosomes are small EVs with diameters of about 30-150 nm and diverse cell sources. METHODS: The MEDLINE/PubMed database was reviewed for papers written in English and publication dates of recent years, using the search string "Exosome" and "Neurodegenerative diseases...
July 26, 2023: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/37487953/role-of-social-context-in-addiction-etiology-and-recovery
#32
JOURNAL ARTICLE
Justin C Strickland, Samuel F Acuff
While social context has long been considered central to substance use disorder prevention and treatment and many drug-taking events occur in social settings, experimental research on social context has historically been limited. Recent years have seen an emergence of concerted preclinical and human laboratory research documenting the direct impact of social context on substance use, delineating behavioral and neurobiological mechanisms underlying social influence's role. We review this emerging preclinical and human laboratory literature from a theoretical lens that considers distinct stages of the addiction process including drug initiation/acquisition, escalation, and recovery...
July 22, 2023: Pharmacology, Biochemistry, and Behavior
https://read.qxmd.com/read/37480348/prospective-pathways-from-affect-to-drug-outcomes-refusal-self-efficacy-in-the-context-of-peer-influences
#33
JOURNAL ARTICLE
Abigail Cheesman, Jennifer P Read
Objective: Non-alcohol drug (NAD) use and its associated consequences remain a prevalent problem among young adults. Both positive and negative affect play etiological roles in NAD. The perception of one's ability to refuse a drug in different situations (drug refusal self-efficacy) could be an important mediator between such affect and NAD outcomes (use and consequences). This study examined mediational pathways from affect to NAD use and NAD-related consequences via drug refusal self-efficacy. We also examined the moderating role of normative perceptions of peer NAD involvement...
July 22, 2023: Substance Use & Misuse
https://read.qxmd.com/read/37466776/impact-of-prenatal-nicotine-exposure-on-placental-function-and-respiratory-neural-network-development
#34
JOURNAL ARTICLE
Sebastián Beltrán-Castillo, Karina Bravo, Jaime Eugenín
Smoking during pregnancy is associated with multiple undesirable outcomes in infants, such as low birth weight, increased neonatal morbidity and mortality, and catastrophic conditions like sudden infant death syndrome (SIDS). Nicotine, the most addictive and teratogenic substance in tobacco smoke, reaches and crosses the placenta and can be accumulated in the amniotic fluid and distributed by fetal circulation, altering the cholinergic transmission by acting on the nicotinic acetylcholine receptors (nAChRs) expressed from very early gestational stages in the placenta and fetal tissue...
2023: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/37385516/paternal-morphine-exposure-in-rats-reduces-social-play-in-adolescent-male-progeny-without-affecting-drug-taking-behavior-in-juvenile-males-or-female-offspring
#35
JOURNAL ARTICLE
Dana Zeid, Andre B Toussaint, Carmen C Dressler, Samuel P Schumacher, Chau Do, Heather Desalvo, Danait Selamawi, Angela R Bongiovanni, Hannah L Mayberry, Gregory V Carr, Mathieu E Wimmer
The ongoing opioid addiction crisis necessitates the identification of novel risk factors to improve prevention and treatment of opioid use disorder. Parental opioid exposure has recently emerged as a potential regulator of offspring vulnerability to opioid misuse, in addition to heritable genetic liability. An understudied aspect of this "missing heritability" is the developmental presentation of these cross-generational phenotypes. This is an especially relevant question in the context of inherited addiction-related phenotypes, given the prominent role of developmental processes in the etiology of psychiatric disorders...
June 27, 2023: Molecular and Cellular Neurosciences
https://read.qxmd.com/read/37366696/the-big-five-personality-domains-and-their-facets-empirical-relations-to-problematic-use-of-video-games-social-media-and-alcohol
#36
JOURNAL ARTICLE
Lutz Wartberg, Katrin Potzel, Carolin Spindler, Rudolf Kammerl
Relatively common behavioral patterns in adolescence are problematic use of video games (PG), social media (PSMU) or alcohol (PAU). According to theoretical models, personality traits are relevant for Internet-related problematic behaviors. In the present study, associations of the Big Five personality domains and their 15 facets with PG, PSMU and PAU were compared for the first time. Therefore, 492 adolescents (mean age: 16.83 years) were examined with the established Big Five Inventory-2 as well as other standardized questionnaires on PG, PSMU and PAU...
May 24, 2023: Behavioral Sciences
https://read.qxmd.com/read/37364655/social-media-use-as-a-risk-factor-for-depressive-symptoms-during-pregnancy
#37
JOURNAL ARTICLE
L Muskens, L P Hulsbosch, M I van den Heuvel, E A J Croes, W J Kop, V J M Pop, M G B M Boekhorst
BACKGROUND: Accumulating research has shown associations between excessive social media use (SMU) with depressive symptoms. Depression is common during pregnancy, but it is not known whether SMU plays a role in the etiology and clinical course of depressive symptoms during pregnancy. METHODS: The current study is a prospective cohort study with Dutch-speaking pregnant women recruited at the first antenatal appointment (N = 697). Depressive symptoms were measured at each trimester of pregnancy using the Edinburgh Depression Scale...
June 24, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/37341771/-anxiety-and-substance-abuse-disorders-focus-on-alcohol-and-cannabis
#38
JOURNAL ARTICLE
Sabine Hellwig, Katharina Domschke
Anxiety disorders are frequent, with a 12-month prevalence of 14%, tend to be chronic, and display a high comorbidity with substance abuse disorders. Anxiety and substance abuse disorders are associated with a pronounced individual as well as socioeconomic burden. This article reviews the epidemiological, etiological, and clinical aspects of the dual diagnosis of anxiety and substance abuse disorders, with a particular focus on alcohol and cannabis. The treatment comprises nonpharmacological strategies, mainly cognitive behavioral therapy combined with elements of motivational interviewing (MI) and pharmacological management with antidepressants; however, the use of selective serotonin reuptake inhibitors (SSRI)/serotonin and noradrenaline reuptake inhibitors (SNRI) is not unreservedly recommended...
June 21, 2023: Der Nervenarzt
https://read.qxmd.com/read/37339914/drinking-motives-alcohol-misuse-and-internalizing-and-externalizing-psychopathology-across-college-a-cross-lagged-panel-study
#39
JOURNAL ARTICLE
Jeanne E Savage, Danielle M Dick
Background: Drinking motives are strong proximal predictors of alcohol use behaviors and may represent a mediational mechanism by which different individual predispositions toward internalizing or externalizing psychopathology lead to the development of alcohol misuse. However, whether the association is due to a causal relationship or a shared etiology (i.e., confounding) is difficult to determine and may change across developmental periods. Methods: This study leveraged a cross-lagged panel design to disentangle the nature of the relationships between self-report measures of drinking motives, alcohol misuse, and internalizing and externalizing psychopathology in a 4-year longitudinal sample of college students ( N  = 9,889)...
June 20, 2023: Substance Use & Misuse
https://read.qxmd.com/read/37266331/the-human-neurosecretome-extracellular-vesicles-and-particles-evps-of-the-brain-for-intercellular-communication-therapy-and-liquid-biopsy-applications
#40
REVIEW
Taliah Soleymani, Tzu-Yi Chen, Edgar Gonzalez-Kozlova, Navneet Dogra
Emerging evidence suggests that brain derived extracellular vesicles (EVs) and particles (EPs) can cross blood-brain barrier and mediate communication among neurons, astrocytes, microglial, and other cells of the central nervous system (CNS). Yet, a complete understanding of the molecular landscape and function of circulating EVs & EPs (EVPs) remain a major gap in knowledge. This is mainly due to the lack of technologies to isolate and separate all EVPs of heterogeneous dimensions and low buoyant density...
2023: Frontiers in Molecular Biosciences
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