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https://www.readbyqxmd.com/read/27905374/-diagnosis-and-treatment-of-inflammatory-diseases-of-the-mammary-ducts
#1
G A Belonenko, A G Grintsov, A G Osipov, G G Pilyugin, Yu G Lutsenko, E G Aksenova, A A Aksenov
AIM: The analysis and popularization of the own experience of ultrasonic diagnostics and minimal invasive interventions for inflammatory diseases of the mammary ducts. PATIENTS AND METHODS: 249 women were observed: 182 (73.1%) cases of periductal mastitis and 67 (26.9%) cases of purulent galactophoritis. Patients with purulent galactophoritis were divided into 2 groups (main and control). The main group consisted of 50 patients after minimal invasive interventions, control - 17 women after traditional surgery...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27890916/polydatin-ameliorates-staphylococcus-aureus-induced-mastitis-in-mice-via-inhibiting-tlr2-mediated-activation-of-the-p38-mapk-nf-%C3%AE%C2%BAb-pathway
#2
Kang-Feng Jiang, Gan Zhao, Gan-Zhen Deng, Hai-Chong Wu, Nan-Nan Yin, Xiu-Ying Chen, Chang-Wei Qiu, Xiu-Li Peng
Recent studies show that Polydatin (PD) extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. In this study, we investigated the anti-inflammatory effects of PD on Staphylococcus aureus-induced mastitis in mice and elucidated the potential mechanisms. In mice with S aureus-induced mastitis, administration of PD (15, 30, 45 mg/kg, ip) or dexamethasone (Dex, 5 mg/kg, ip) significantly suppressed the infiltration of inflammatory cells, ameliorated the mammary structural damage, and inhibited the activity of myeloperoxidase, a biomarker of neutrophils accumulation...
November 28, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27882115/retrospective-analysis-of-seven-breast-tuberculosis-cases
#3
Beyhan Çakar, Aydin Çiledağ
The present study aimed to evaluate the demographic data, diagnostic methods, therapeutic regimens and duration of therapy in 7 breast tuberculosis (BTB) cases. The data of BTB cases treated between January 2006 and December 2013 were retrospectively evaluated, with a total of 648 tuberculosis (TB) cases recorded during the 8-year period. Among these cases, 296 patients (50%) suffered from pulmonary TB, 278 (43%) from non-pulmonary TB and 45 (7%) from PTB plus NPTB. In total, 7 BTB were diagnosed, which constituted 1...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27874095/longitudinal-metagenomic-profiling-of-bovine-milk-to-assess-the-impact-of-intramammary-treatment-using-a-third-generation-cephalosporin
#4
Erika K Ganda, Rafael S Bisinotto, Svetlana F Lima, Kristina Kronauer, Dean H Decter, Georgios Oikonomou, Ynte H Schukken, Rodrigo C Bicalho
Antimicrobial usage in food animals has a direct impact on human health, and approximately 80% of the antibiotics prescribed in the dairy industry are used to treat bovine mastitis. Here we provide a longitudinal description of the changes in the microbiome of milk that are associated with mastitis and antimicrobial therapy. Next-generation sequencing, 16 S rRNA gene quantitative real-time PCR, and aerobic culturing were applied to assess the effect of disease and antibiotic therapy on the milk microbiome...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872722/production-of-monoclonal-antibody-against-recombinant-ns3-protein-of-bovine-viral-diarrhea-virus-nadl-strain
#5
Masood Reza Seyfi Abad Shapouri, Maryam Ekhtelat, Masood Ghorbanpoor Najaf Abadi, Mohsen Lotfi, Mohamad Rashno
This study was conducted to investigate the prevalence of subclinical mastitis caused by Staphylococcus spp. in ewes in West-Azerbaijan province of Iran. Molecular characterization of isolated Staphylococcus spp. from diseased ewes were performed using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) and DNA sequencing of glyceraldehyde-3-phosphate dehydrogenase (gap) gene. Also, antibiotic resistance of staphylococcal isolates against different antibiotics was investigated...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27871373/design-and-production-of-antibodies-for-the-detection-of-streptococcus-uberis
#6
K Mihklepp, K Kivirand, M Nikopensius, D Peedel, M Utt, T Rinken
Streptococcus uberis (S. uberis) is an important environmental pathogen causing mastitis in dairy cattle. Mastitis or mammary gland infection is the most common disease in milking cows and cause significant economic burden to farmers due to the reduction of the amount of milk and its quality. The development of rapid analytical methods for the determination of mastitis-causing pathogens in milk is of utmost importance for the early identification of the causes of mastitis and the beginning of timely treatment of cows...
January 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27865491/prevalence-and-risk-factors-for-extended-spectrum-beta-lactamase-or-ampc-producing-escherichia-coli-in-organic-dairy-herds-in-the-netherlands
#7
I M G A Santman-Berends, M A Gonggrijp, J J Hage, A E Heuvelink, A Velthuis, T J G M Lam, G van Schaik
Extended-spectrum β-lactamase and AmpC-producing Escherichia coli (ESBL/AmpC) are an emerging problem and are hypothesized to be associated with antimicrobial use (AMU), and more specifically with the use of third- and fourth-generation cephalosporins. Whether ESBL/AmpC also occur in organic dairy herds, which have restricted AMU, is not known. Additionally, it is unknown whether, in addition to restricted AMU, other factors in organic herd management are associated with ESBL/AmpC herd status. The aim of this study was to estimate the prevalence of ESBL/AmpC in organic dairy herds in the Netherlands...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27853497/imaging-findings-in-patients-with-granulomatous-mastitis
#8
Pelin Seher Oztekin, Gamze Durhan, Pinar Nercis Kosar, Serap Erel, Sema Hucumenoglu
BACKGROUND: Granulomatous mastitis (GM) is a rare inflammatory breast disease that may mimic the clinical characteristics and radiologic imaging findings of breast carcinoma. Considering the importance of making a correct diagnosis, careful radiologic evaluations and recognition of imaging features are necessary. OBJECTIVES: The aim of this study was to review the radiological findings and diagnostic value of the imaging in GM. PATIENTS AND METHODS: This retrospective study involved a total of 29 patients who were diagnosed with GM between 2009 and 2013 and who underwent mammography (MG) and/or ultrasound (US) examination in addition to magnetic resonance imaging (MRI) before diagnosis...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27845022/selection-of-cows-for-treatment-at-dry-off-on-organic-dairy-farms
#9
Klemens Kiesner, Nicole Wente, Otto Volling, Volker Krömker
Restrictions regarding the use of antibiotics make selective antibiotic dry cow therapy (DCT) mandatory on organic farms in Germany. This requires methods for identifying cows with an intramammary infection (IMI) at dry-off. The aim of this field study was to create a decision scheme for the use of DCT based on cow level factors associated with IMI at dry-off and the probability of both cure and new infection (NI) during the dry period. Data from 250 cows from five organic farms were collected including somatic cell counts (SCC) from Dairy Herd Improvement (DHI) records, California mastitis test (CMT) results at dry-off, clinical mastitis (CM) history, parity and dry-off treatment...
November 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27845019/the-value-of-pathogen-information-in-treating-clinical-mastitis
#10
Elva Cha, Rebecca L Smith, Anders R Kristensen, Julia A Hertl, Ynte H Schukken, Loren W Tauer, Frank L Welcome, Yrjö T Gröhn
The objective of this study was to determine the economic value of obtaining timely and more accurate clinical mastitis (CM) test results for optimal treatment of cows. Typically CM is first identified when the farmer observes recognisable outward signs. Further information of whether the pathogen causing CM is Gram-positive, Gram-negative or other (including no growth) can be determined by using on-farm culture methods. The most detailed level of information for mastitis diagnostics is obtainable by sending milk samples for culture to an external laboratory...
November 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27845018/is-lack-of-antibiotic-usage-affecting-udder-health-status-of-organic-dairy-cattle
#11
Inmaculada Orjales, Marta López-Alonso, Ruth Rodríguez-Bermúdez, Francisco Rey-Crespo, Ana Villar, Marta Miranda
This research communication aimed to compare somatic cell count (SCC), the main marker of udder health status, in organic farms not using antibiotics (O, n = 6), organic farms using antibiotics (OA, n = 7) and conventional farms (CA, n = 5) using antibiotic treatments, all of them at pasture. SCC was statistically significantly higher in O (173780) compared to CA (93325) and OA (107152). Milk yield had a significant diluting effect on SCC and differences between groups increased with parities. Stratified analysis of SCC depending on lactation number and % of monthly SCC test with different linear scores (LS) indicated that there is no difference in udder health in the primiparous heifers from the three groups of farms, but it deteriorates in older cows because of chronic infections in O (possibly due to lack of antibiotic use)...
November 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27818578/apoptosis-of-endothelial-cells-by-13-hpode-contributes-to-impairment-of-endothelial-barrier-integrity
#12
Valerie E Ryman, Nandakumar Packiriswamy, Lorraine M Sordillo
Inflammation is an essential host response during bacterial infections such as bovine mastitis. Endothelial cells are critical for an appropriate inflammatory response and loss of vascular barrier integrity is implicated in the pathogenesis of Streptococcus uberis-induced mastitis. Previous studies suggested that accumulation of linoleic acid (LA) oxygenation products derived from 15-lipoxygenase-1 (15-LOX-1) metabolism could regulate vascular functions. The initial LA derivative from the 15-LOX-1 pathway, 13-hydroperoxyoctadecadienoic acid (HPODE), can induce endothelial death, whereas the reduced hydroxyl product, 13-hydroxyoctadecadienoic acid (HODE), is abundantly produced during vascular activation...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27815454/plasma-cell-mastitis-in-men-a-single-center-experience-and-review-of-the-literature
#13
REVIEW
Andrea Palmieri, Valerio D'Orazi, Giovanni Martino, Federico Frusone, Daniele Crocetti, Maria Ida Amabile, Marco Monti
Plasma cell mastitis is an inflammatory disease of the breast parenchyma, rare in males. In the last 40 years, few cases have been described in literature. Our recent treatment of male patients affected by plasma cell mastitis raised a series of issues which led us to carry out a critical review of the literature. Plasma cell mastitis is often not well defined and is difficult to assess by clinical examination and radiological investigation alone. An understanding of the pathogenesis and the mechanisms behind plasma cell mastitis may help improve the diagnostic and therapeutic course of the disease, leading to a more targeted and less invasive treatment...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27801370/antimicrobial-resistance-levels-amongst-staphylococci-isolated-from-clinical-cases-of-bovine-mastitis-in-kosovo
#14
Ibrahim Mehmeti, Behlul Behluli, Mergim Mestani, Arsim Ademi, Ingolf F Nes, Dzung B Diep
INTRODUCTION: Mastitis is one of the most frequent and costly disease in cattle. We studied milk samples from cattle with mastitis from farms in Kosovo to identify mastitis-causing pathogens and possible effective antibiotics. Our ultimate goal is to help implement adequate antibiotic management and treatment practices in Kosovo METHODOLOGY: A total of 152 milk samples were collected from cows with clinical mastitis from different farms in Kosovo. After identification of microorganisms, antibiotic susceptibility and the occurrence of enterotoxins was investigated...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27774090/dose-assessment-of-cefquinome-by-pharmacokinetic-pharmacodynamic-modeling-in-mouse-model-of-staphylococcus-aureus-mastitis
#15
Yang Yu, Yu-Feng Zhou, Xiao Li, Mei-Ren Chen, Gui-Lin Qiao, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu
This work aimed to characterize the mammary gland pharmacokinetics of cefquinome after an intramammary administration and integrate pharmacokinetic/pharmacodynamic model. The pharmacokinetic profiles of cefquinome in gland tissue were measured using high performance liquid chromatograph. Therapeutic regimens covered various dosages ranging from 25 to 800 μg/gland and multiple dosing intervals of 8, 12, and 24 h. The in vivo bacterial killing activity elevated when dosage increased or when dosing intervals were shortened...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27737655/pharmacokinetics-pk-pharmacodynamics-pd-and-pk-pd-integration-of-ceftiofur-after-a-single-intravenous-subcutaneous-and-subcutaneous-la-administration-in-lactating-goats
#16
Emilio Fernández-Varón, Carlos Cárceles-García, Juan Manuel Serrano-Rodríguez, Carlos M Cárceles-Rodríguez
BACKGROUND: Bacterial pneumonia in goats is usually caused by Mannheimia haemolytica and Pasteurella multocida. Another important infection disease in lactating goats is intramammary infection producing mastitis, usually associated with coagulase-negative Staphylococcus spp. However, treatment of bacterial pneumonia in goats not affected by mastitis problems should be restricted to antimicrobials with scant penetration to milk in order to avoid long withdrawal times. Ceftiofur is a third-generation cephalosporin antimicrobial with activity against various gram-positive and gram-negative, aerobic and anaerobic bacteria encountered by domestic animals...
October 13, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27733794/screening-of-antibiotics-and-chemical-analysis-of-penicillin-residue-in-fresh-milk-and-traditional-dairy-products-in-oyo-state-nigeria
#17
Isaac Olufemi Olatoye, Oluwayemisi Folashade Daniel, Sunday Ayobami Ishola
BACKGROUND AND AIM: There are global public health and economic concerns on chemical residues in food of animal origin. The use of antibiotics in dairy cattle for the treatment of diseases such as mastitis has contributed to the presence of residues in dairy products. Penicillin residues as low as 1 ppb can lead to allergic reactions and shift of resistance patterns in microbial population as well as interfere with the processing of several dairy products. Antibiotic monitoring is an essential quality control measure in safe milk production...
September 2016: Veterinary World
https://www.readbyqxmd.com/read/27720156/identification-of-factors-influencing-teat-dip-efficacy-trial-results-by-meta-analysis
#18
B D Enger, R R White, S C Nickerson, L K Fox
Two meta-analyses were conducted using data from peer-reviewed natural exposure (NE) and experimental challenge (EC) teat dip efficacy trials to identify factors influencing the new intramammary infection (IMI) rate. A NE data set containing 16 studies and an EC data set containing 21 studies were created. New IMI rate was calculated based on the percentage of new quarter infections per month (PNQI/mo) for each observation, in both data sets, and used as the dependent variable for model derivation. A linear, mixed-effects model with a random study effect, weighted by number of quarters eligible for infection, was derived for each data set...
October 5, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27718095/indirubin-inhibits-lps-induced-inflammation-via-tlr4-abrogation-mediated-by-the-nf-kb-and-mapk-signaling-pathways
#19
Jin-Lun Lai, Yu-Hui Liu, Chang Liu, Ming-Pu Qi, Rui-Ning Liu, Xi-Fang Zhu, Qiu-Ge Zhou, Ying-Yu Chen, Ai-Zhen Guo, Chang-Min Hu
Indirubin plays an important role in the treatment of many chronic diseases and exhibits strong anti-inflammatory activity. However, the molecular mode of action during mastitis prophylaxis remains poorly understood. In this study, a lipopolysaccharide (LPS)-induced mastitis mouse model showed that indirubin attenuated histopathological changes in the mammary gland, local tissue necrosis, and neutrophil infiltration. Moreover, indirubin significantly downregulated the production of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α)...
October 7, 2016: Inflammation
https://www.readbyqxmd.com/read/27695696/antimicrobial-susceptibility-patterns-of-environmental-streptococci-recovered-from-bovine-milk-samples-in-the-maritime-provinces-of-canada
#20
Marguerite Cameron, Matthew Saab, Luke Heider, J Trenton McClure, Juan Carlos Rodriguez-Lecompte, Javier Sanchez
Determination of antimicrobial susceptibility of bovine mastitis pathogens is important for guiding antimicrobial treatment decisions and for the detection of emerging resistance. Environmental streptococci are ubiquitous in the farm environment and are a frequent cause of mastitis in dairy cows. The aim of the study was to determine patterns of antimicrobial susceptibility among species of environmental streptococci isolated from dairy cows in the Maritime Provinces of Canada. The collection consisted of 192 isolates identified in milk samples collected from 177 cows originating from 18 dairy herds...
2016: Frontiers in Veterinary Science
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