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https://www.readbyqxmd.com/read/29241025/antimicrobial-usage-and-risk-of-retreatment-for-mild-to-moderate-clinical-mastitis-cases-on-dairy-farms-following-on-farm-bacterial-culture-and-selective-therapy
#1
S McDougall, J Niethammer, L E Graham
AIMS: To assess antimicrobial usage for treatment of mild to moderate clinical mastitis, and risk of retreatment, following implementation of an on-farm bacterial culture system and selective therapy based on culture results, and to assess compliance with treatment decision tree protocols and the level of agreement between results from on-farm culture and laboratory-based microbiology methods. MATERIALS AND METHODS: Herdowners from seven dairy herds were asked to collect milk samples from cases of mild to moderate clinical mastitis between July 2015 and May 2016...
December 14, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29240317/inflammations-of-the-mammary-gland
#2
Tuomo Meretoja, Hanna Ihalainen, Marjut Leidenius
Breast inflammation, i.e. mastitis is an entity with a variable etiology and severity, typically affecting women of fertile age. In most cases, anamnesis reveals the etiology of the disease, bacterial puerperal mastitis associated with breastfeeding being the most common. Periductal mastitis is a breast inflammation typically associated with smoking in women of 40 to 50 years of age, localized to the region of the areola. Granulomatous mastitis and other rare breast inflammations usually require specialized care...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29234314/efficacy-and-safety-of-a-bovine-associated-staphylococcus-aureus-phage-cocktail-in-a-murine-model-of-mastitis
#3
Koen Breyne, Ryan W Honaker, Zachary Hobbs, Manuela Richter, Maciej Żaczek, Taylor Spangler, Jonas Steenbrugge, Rebecca Lu, Anika Kinkhabwala, Bruno Marchon, Evelyne Meyer, Lucia Mokres
Overuse of antibiotics is a major problem in the treatment of bovine mastitis, and antibiotic treatment is frequently non-curative, thus alternative treatments are necessary. The primary aim of this study was to evaluate the efficacy of a purified phage cocktail for treatment of bovine Staphylococcus aureus mastitis in a well-defined mouse model. Candidate phages were selected based on their in vitro performance and subsequently processed into an optimally composed phage cocktail. The highest scoring phages were further tested for efficacy and resistance suppression in broth and raw milk, with and without supplemental IgG...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29233776/bovine-mastitis-an-appraisal-of-its-alternative-herbal-cure
#4
REVIEW
Saleem Mushtaq, Aabid Manzoor Shah, Aiyatullah Shah, Sajad Ahmad Lone, Aehtesham Hussain, Qazi Parvaiz Hassan, Md Niamat Ali
Bovine mastitis is globally recognised as the most common and costly disease affecting dairy herds. The disease causes huge financial losses to dairy industries by reduced yield and milk quality, deaths and culling of affected cows and also by associated treatment costs. The disease occurs due to invasion of the mammary glands by pathogenic bacteria followed by their multiplication in the milk producing tissues. The most common treatment method available against bovine mastitis is the intra-mammary infusion of antibiotics...
December 9, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29224885/economic-optimization-of-selective-dry-cow-treatment
#5
C G M Scherpenzeel, H Hogeveen, L Maas, T J G M Lam
The objective of this study was to develop a mathematical model to identify a scenario with the lowest costs for mastitis associated with the dry period while restricting the percentage of cows to be dried off with dry cow antimicrobials. Costs of clinical and subclinical mastitis as well as antimicrobial use were quantified. Based on data from a large field trial, a linear programming model was built with the goal to minimize the costs associated with antimicrobial use at drying off. To enable calculations on minimizing costs of dry cow treatment on herd-level by drying-off decisions in an "average" herd, we created an example herd...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224874/prepartum-application-of-internal-teat-sealant-or-intramammary-amoxicillin-on-dairy-heifers-effect-on-udder-health-survival-and-performance
#6
V S Machado, R C Bicalho
Intramammary infusion of antimicrobials (IA) and application of an internal teat sealant (ITS) at the end of the lactation is a common strategy to prevent and treat intramammary infections during the dry period. In heifers, precalving IA has been reported to improve udder health and milk quality; however, the effect of ITS in heifers housed in freestall barns is still unknown. The objective of this study was to investigate the effect of prepartum application of ITS or IA on udder health of dairy heifers. A total of 886 heifers were randomly allocated into 1 of 4 treatment groups when they were 245 ± 3 d pregnant...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29205189/staphylococcus-aureus-biofilm-removal-by-targeting-biofilm-associated-extracellular-proteins
#7
Sudhir K Shukla, T Subba Rao
BACKGROUND & OBJECTIVES: Among cell surface proteins, biofilm-associated protein (Bap) promotes biofilm development in Staphylococcus aureus strains. The aim of this study was to investigate proteinase-mediated biofilm dispersion in different isolates of S. aureus. METHODS: Biofilm assay was done in 96-well microtitre plate to evaluate the effect of proteinase K on biofilms of bovine mastitis S. Aureus isolates. Extracellular polymeric substances were extracted and evaluated for their composition (protein, polysaccharides and extracellular DNA), before and after the proteinase K treatment...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29204872/anti-inflammatory-effects-of-rosmarinic-acid-in-lipopolysaccharide-induced-mastitis-in-mice
#8
Kangfeng Jiang, Xiaofei Ma, Shuai Guo, Tao Zhang, Gan Zhao, Haichong Wu, Xiaoyan Wang, Ganzhen Deng
Rosmarinic acid (RA), a type of food additives mainly extracted from rosemary, has been reported to possess anti-inflammatory activities in some previous studies. However, the effects of RA on lipopolysaccharide (LPS)-induced mastitis have not been reported. Here, we investigated the anti-inflammatory effects of RA on LPS-induced mastitis in mice and elucidated the potential mechanisms in mouse mammary epithelial cells (mMECs). RA treatment significantly ameliorated the mammary structural damage, and reduced the activity of myeloperoxidase...
December 4, 2017: Inflammation
https://www.readbyqxmd.com/read/29177138/homology-modeling-and-virtual-screening-to-discover-potent-inhibitors-targeting-the-imidazole-glycerophosphate-dehydratase-protein-in-staphylococcus-xylosus
#9
Xing-Ru Chen, Xiao-Ting Wang, Mei-Qi Hao, Yong-Hui Zhou, Wen-Qiang Cui, Xiao-Xu Xing, Chang-Geng Xu, Jing-Wen Bai, Yan-Hua Li
The imidazole glycerophosphate dehydratase (IGPD) protein is a therapeutic target for herbicide discovery. It is also regarded as a possible target in Staphylococcus xylosus (S. xylosus) for solving mastitis in the dairy cow. The 3D structure of IGPD protein is essential for discovering novel inhibitors during high-throughput virtual screening. However, to date, the 3D structure of IGPD protein of S. xylosus has not been solved. In this study, a series of computational techniques including homology modeling, Ramachandran Plots, and Verify 3D were performed in order to construct an appropriate 3D model of IGPD protein of S...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29158993/antimicrobial-consumption-on-austrian-dairy-farms-an-observational-study-of-udder-disease-treatments-based-on-veterinary-medication-records
#10
Clair L Firth, Annemarie Käsbohrer, Corina Schleicher, Klemens Fuchs, Christa Egger-Danner, Martin Mayerhofer, Hermann Schobesberger, Josef Köfer, Walter Obritzhauser
Background: Antimicrobial use in livestock production is an important contemporary issue, which is of public interest worldwide. Antimicrobials are not freely available to Austrian farmers and can only be administered to livestock by veterinarians, or by farmers who are trained members of the Animal Health Service. Since 2015, veterinarians have been required by law to report antimicrobials dispensed to farmers for use in food-producing animals. The study presented here went further than the statutory framework, and collected data on antimicrobials dispensed to farmers and those administered by veterinarians...
2017: PeerJ
https://www.readbyqxmd.com/read/29157376/epidemiological-and-partial-budget-analysis-for-treatment-of-subclinical-staphylococcus-aureus-intramammary-infections-considering-microbiological-and-cytological-scenarios
#11
Inge-Marié Petzer, Eric M C Etter, Edward F Donkin, Edward C Webb, Joanne Karzis
An innovative method was investigated to aid in the elimination of Staphylococcus aureus (S. aureus) intramammary infections (IMI) from dairy herds. A stochastic model explore the economic benefit of three-day or eight-day treatment of subclinical IMI in all S. aureus infected cows or in only those with a somatic cell count (SCC) exceeding 200,000 cells/ml. An epidemiological model was developed to run parallel to the economic model that would predict the S. aureus IMI likely to persist, develop new infections and clinical mastitis...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29154739/oxidative-stress-induced-inflammatory-responses-and-effects-of-n-acetylcysteine-in-bovine-mammary-alveolar-cells
#12
Hyojin Bae, Chang Hee Jeong, Wei Nee Cheng, Kwonho Hong, Han Geuk Seo, Sung Gu Han
Bovine mastitis, an inflammation of the udder, results in reduced milk production and poor milk quality. Mastitis is usually, but not always, a response to pathogen infection. High milk yield can produce oxidative stress in the mammary tissue. High milk yield is also known to be associated with bovine mastitis. Thus, in the current study, we hypothesised that oxidative stress increases inflammatory responses in bovine mammary cells. To examine the hypothesis, we produced cellular oxidative stress and investigated resulting inflammatory responses in bovine mammary alveolar cells (MAC-T)...
November 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/29153520/retrospective-analysis-of-austrian-health-recording-data-of-antibiotic-or-nonantibiotic-dry-off-treatment-on-milk-yield-somatic-cell-count-and-frequency-of-mastitis-in-subsequent-lactation
#13
T Wittek, A Tichy, B Grassauer, C Egger-Danner
Typically, dairy cows are dried off at the end of lactation. During the dry period, intramammary infections may be cured or persist, and new infections may occur. Traditionally, antibiotics (AB) have been used at dry-off. However, blanket antibiotic dry-off treatment may no longer be justifiable and, recently, selective use of antibiotics at dry off has been proposed and different decision criteria suggested. The objective of the study was to evaluate cows receiving antibiotic treatment at dry off (AB group) compared with cows dried off without antibiotics (non-AB group) using a large data set...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29151337/coexistence-of-idiopathic-granulomatous-mastitis-and-erythemanodosum-successful-treatment-with-corticosteroids
#14
Murat Akın, Harun Karabacak, Güldal Esendağlı, Aydın Yavuz, Serap Gültekin, Kürşat Dikmen, Hasan Bostancı
Background/aim: Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory disease of the breast. Erythema nodosum (EN) is a rare extramammary manifestation of IGM. The purpose of this study is to determine the clinical and demographic characteristics of 11 IGM and EN patients and to evaluate the efficacy of methylprednisolone treatment. Materials and methods: In our series, ten patients had EN bilaterally, whereas one patient had a lesion of the right pretibial area. The mean age of the patients was 35...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29138800/broadleaf-mahonia-attenuates-granulomatous-lobular-mastitis%C3%A2-associated-inflammation-by-inhibiting-ccl%C3%A2-5-expression-in-macrophages
#15
Zhiyu Wang, Neng Wang, Xiaoyan Liu, Qi Wang, Biao Xu, Pengxi Liu, Huayu Zhu, Jianping Chen, Honglin Situ, Yi Lin
Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requirement that safe and efficient natural drugs are found to improve the GLM prognosis. Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti‑inflammatory properties according to ancient records of traditional Chinese medicine...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29136922/immunosensing-system-for-rapid-multiplex-detection-of-mastitis-causing-pathogens-in-milk
#16
Delia Juronen, Ave Kuusk, Kairi Kivirand, Ago Rinken, Toonika Rinken
Mastitis, an inflammation of the mammary gland and udder tissue, is the major endemic disease of dairy cattle. In addition to causing health problems to the animals, mastitis leads to the reduction of milk production and quality, representing a significant economic burden for farmers. To enable timely treatment of infected animals with pathogen-specific antibiotics, the development of automated analytical methods for rapid on-site identification and quantification of mastitis-causing pathogens in milk is particularly important...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29134942/intramammary-infusion-of-a-live-culture-of-lactococcus-lactis-in-ewes-to-treat-staphylococcal-mastitis
#17
Sebastian Alessandro Mignacca, Simone Dore, Liliana Spuria, Pietro Zanghì, Benedetta Amato, Ilaria Duprè, Federica Armas, Elena Biasibetti, Cristina Camperio, Stefano A Lollai, Maria Teresa Capucchio, Eugenia Agnese Cannas, Vincenzo Di Marco Lo Presti, Cinzia Marianelli
PURPOSE: Alternatives to antibiotic therapy for mastitis in ruminants are needed. We present an evaluation, in two trials, of the efficacy of an intramammary infusion of a live culture of Lactococcus lactis for the treatment of subclinical and clinical mastitis in ewes. METHODOLOGY: In total, 67 animals were enrolled: 19 lactating ewes (study 1), including healthy (N=6) and coagulase-negative staphylococci (CNS)-infected ewes (N=13); and 48 lactating ewes (study 2) with either CNS mastitis (N=32), or Staphylococcus aureus mastitis (N=16), for a total of 123 mammary glands...
November 14, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29129139/effect-of-using-an-internal-teat-sealant-at-drying-off-in-cows-wintered-on-forage-crops-in-new-zealand-on-culling-in-the-dry-period-and-early-lactation
#18
A J Bates, B Saldias
AIMS: To determine the impact of treatment with internal teat sealant (ITS) compared to no treatment at drying-off on culling during the dry period and 90 days after calving, for cows wintered on forage crops. METHODS: In four dairy herds in the South Island of New Zealand, cows with no history of clinical mastitis or somatic cell counts >100,000 cells/mL during the 2015-16 season were randomly assigned to treatment with ITS in each quarter (ITS group) or no treatment (Control group)...
November 12, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29117479/effect-of-treatment-with-an-internal-teat-sealant-at-drying-off-in-cows-wintered-on-forage-crops-in-new-zealand-on-clinical-mastitis-and-somatic-cell-counts
#19
A J Bates, B Saldias
AIMS: To determine the impact of treatment with internal teat sealant (ITS) compared to no treatment at drying-off on the incidence of clinical mastitis (CM) during the dry period and 84 days after calving, and the prevalence of cows with somatic cell counts (SCC) ≥200,000 cells/mL at the first lactation herd test, for cows wintered on forage crops. METHODS: In four dairy herds in the South Island of New Zealand, cows with no history of CM or individual SCC >100,000 cells/mL during the 2015-16 season were randomly assigned to treatment with ITS in each quarter (ITS group) at drying-off or no treatment (Control group)...
November 8, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29113806/cynatratoside-c-from-cynanchum-atratum-displays-anti-inflammatory-effect-via-suppressing-tlr4-mediated-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways-in-lps-induced-mastitis-in-mice
#20
Ge Hu, Dong Hong, Tao Zhang, Huiqin Duan, Panying Wei, Xinxin Guo, Xiang Mu
The present study was conducted to isolate anti-inflammatory compound from Cynanchum atratum and investigate the molecular mechanisms of active compound against lipopolysaccharide (LPS)-induced mastitis in mice. Bioassay-guided fractionations and isolation (via ex vivo tests) of compounds with anti-inflammatory activity were performed on roots of C. atratum yielding a pure bioactive compound: Cynatratoside-C, identified by comparing spectral data (EI-MS, (1)H NMR and (13)C NMR) with literature values. Ex vivo tests showed that Cynatratoside-C inhibited the expression of TLR4 and pro-inflammatory cytokine (TNF-α, IL-6 and IL-1β) production in LPS-stimulated primary mouse mammary epithelial cells...
November 4, 2017: Chemico-biological Interactions
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