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Knee cartilage injury

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https://www.readbyqxmd.com/read/28345597/post-traumatic-osteoarthritis-in-mice-following-mechanical-injury-to-the-synovial-joint
#1
Muhammad Farooq Rai, Xin Duan, James D Quirk, Nilsson Holguin, Eric J Schmidt, Nobuaki Chinzei, Matthew J Silva, Linda J Sandell
We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury. We hypothesized that alteration in knee joint stability in mice reproduces molecular and structural features of PTOA that would suggest potential therapeutic targets in humans. The right knees of eight-week old male mice from two recombinant inbred lines (LGXSM-6 and LGXSM-33) were subjected to axial tibial compression. Three separate loading magnitudes were applied: 6N, 9N, and 12N...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345404/are-bone-bruise-characteristics-and-articular-cartilage-pathology-associated-with-inferior-outcomes-2-and-6-years-after-anterior-cruciate-ligament-reconstruction
#2
Christian Lattermann, Cale A Jacobs, Emily K Reinke, Erica A Scaramuzza, Laura J Huston, Warren R Dunn, Kurt P Spindler
Objective To determine (1) if bone bruise characteristics seen on magnetic resonance imaging are associated with patient-reported outcomes prior to and following anterior cruciate ligament reconstruction and (2) if the combined presence of bone bruises with articular cartilage pathology results in inferior 2- or 6-year outcomes. Design Bone bruise volume and severity were measured on 81 patients' preoperative magnetic resonance imaging in the medial and lateral femoral condyle (MFC, LFC) and medial and lateral tibial plateau (MTP, LTP) using the Costa-Paz classification and a modified version of Roemer and Bohndorf's technique...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28325693/surgical-technique-and-clinical-outcomes-of-retrograde-osteochondral-autograft-transfer-for-osteochondral-lesions-of-the-tibial-plateau
#3
Hiromitsu Yabumoto, Yasuaki Nakagawa, Shogo Mukai, Takahiko Saji, Takashi Nakamura
PURPOSE: To present the surgical technique, clinical outcomes, and poor prognostic factors of arthroscopic retrograde osteochondral autograft transfer of the tibial plateau. METHODS: Twelve patients (6 men, 6 women; mean age, 38.7 years) with tibial plateau osteochondral lesions underwent surgery. The primary diseases were osteonecrosis in 4 cases, cartilage injuries in 6, and postfractures of the tibial plateau in 2. Clinical outcomes were evaluated preoperatively and postoperatively according to the International Knee Documentation Committee score and the Japanese Orthopaedic Association score...
March 18, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28319418/autologous-cartilage-chip-transplantation-improves-repair-tissue-composition-compared-with-marrow-stimulation
#4
Bjørn Borsøe Christensen, Morten Lykke Olesen, Martin Lind, Casper Bindzus Foldager
BACKGROUND: Repair of chondral injuries by use of cartilage chips has recently demonstrated clinical feasibility. PURPOSE: To investigate in vivo cartilage repair outcome of autologous cartilage chips compared with marrow stimulation in full-thickness cartilage defects in a minipig model. STUDY DESIGN: Controlled laboratory study. METHODS: Six Göttingen minipigs received two 6-mm chondral defects in the medial and lateral trochlea of each knee...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28299389/adolescents-and-female-patients-are-at-increased-risk-for-contralateral-anterior-cruciate-ligament-reconstruction-a-cohort-study-from-the-swedish-national-knee-ligament-register-based-on-17-682-patients
#5
Thorkell Snaebjörnsson, Eric Hamrin Senorski, David Sundemo, Eleonor Svantesson, Olof Westin, Volker Musahl, Eduard Alentorn-Geli, Kristian Samuelsson
PURPOSE: The impact of different surgical techniques in index ACL reconstruction for patients undergoing contralateral ACL reconstruction was investigated. METHODS: The study was based on data from the Swedish National Knee Ligament Register. Patients undergoing index ACL reconstruction and subsequent contralateral ACL reconstruction using hamstring graft under the study period were included. The following variables were evaluated: age at index surgery, gender, concomitant meniscal or cartilage injury registered at index injury, transportal femoral bone tunnel drilling and transtibial femoral bone tunnel drilling...
March 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28298062/traumatic-patellar-dislocation-and-cartilage-injury
#6
Essi E Salonen, Teemu Magga, Petri J Sillanpää, Tommi Kiekara, Heikki Mäenpää, Ville M Mattila
BACKGROUND: Patellofemoral cartilage deterioration and osteoarthritis are reported to be associated with recurrent patellar dislocation. However, the association between first-time traumatic patellar dislocation and cartilage deterioration is unknown. PURPOSE: The aim of this study was to assess long-term cartilage deterioration in the patellofemoral and tibiofemoral joint after conservatively treated traumatic lateral patellar dislocation. STUDY DESIGN: Case series; Level of evidence, 4...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28282672/all-arthroscopic-autologous-matrix-induced-chondrogenesis-aided-repair-of-a-patellar-cartilage-defect-using-dry-arthroscopy-and-a-retraction-system
#7
Boguslaw Sadlik, Mariusz Puszkarz, Lidia Kosmalska, Martin Wiewiorski
The technique of all-arthroscopic autologous matrix-induced chondrogenesis (AMIC)-aided repair of patellar cartilage lesions using a retraction system and dry arthroscopy has been recently described. We report the first clinical and radiological data at a short-term follow-up. Twelve patients underwent AMIC-aided cartilage repair for a patellar lesion. All steps of the procedure were performed arthroscopically, which include the use of an intra-articularly placed retraction plate for distraction of the patellofemoral joint and evacuation of saline solution for collagen matrix insertion and fixation...
March 10, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28282221/collagen-augmentation-improves-the-quality-of-cartilage-repair-after-microfracture-in-patients-undergoing-high-tibial-osteotomy
#8
Man Soo Kim, In Jun Koh, Young Jun Choi, Kyu Hyung Pak, Yong In
BACKGROUND: The quality of cartilage repair after marrow stimulation is unpredictable. To overcome the shortcomings of the microfracture technique, various augmentation techniques have been developed. However, their efficacies remain unclear. HYPOTHESIS: The quality of cartilage repair and clinical outcomes would be superior in patients undergoing high tibial osteotomy (HTO) with microfracture and collagen augmentation compared to those undergoing HTO with microfracture alone without collagen augmentation for the treatment of medial compartment osteoarthritis (OA) of the knee...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28280907/high-prevalence-of-knee-osteoarthritis-at-a-minimum-10-year-follow-up-after-knee-dislocation-surgery
#9
Gilbert Moatshe, Grant J Dornan, Tom Ludvigsen, Sverre Løken, Robert F LaPrade, Lars Engebretsen
PURPOSE: Long-term outcomes and the prevalence of osteoarthritis after surgical treatment of knee dislocations are lacking in the literature. The purpose of this study was to investigate the prevalence of knee osteoarthritis and knee function at a minimum of 10 years after knee dislocation surgery. METHODS: Sixty-five patients surgically treated for knee dislocations at a single level I trauma center between May 1996 and December 2004 were evaluated at a minimum of 10 years...
March 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28277753/the-absence-of-detectable-adamts-4-aggrecanase-1-activity-in-synovial-fluid-is-a-predictive-indicator-of-autologous-chondrocyte-implantation-success
#10
Karina Therese Wright, Jan Herman Kuiper, James Bruce Richardson, Pete Gallacher, Sally Roberts
BACKGROUND: Autologous chondrocyte implantation (ACI) is used worldwide in the treatment of cartilage defects in the knee. Several demographic and injury-specific risk factors have been identified that can affect the success of ACI treatment. However, the discovery of predictive biomarkers in this field has thus far been overlooked. PURPOSE: To identify potential biomarkers in synovial fluid and plasma that can be used in the preoperative setting to help optimize patient selection for cell-based cartilage repair strategies...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28277739/the-effect-of-postoperative-kt-1000-arthrometer-score-on-long-term-outcome-after-anterior-cruciate-ligament-reconstruction
#11
Andrew D Goodwillie, Sarav S Shah, Malachy P McHugh, Stephen J Nicholas
BACKGROUND: Many long-term studies have looked at outcomes after anterior cruciate ligament reconstruction (ACLR), but none have correlated long-term outcomes with postoperative laxity greater than 5 mm. It has been stated previously that more than 5 mm of postoperative graft laxity constituted a procedural failure. PURPOSE: To directly compare tight grafts (<3 mm) and loose grafts (>5 mm) to determine the effect of graft laxity, as measured by KT-1000 arthrometer, after ACLR on long-term clinical outcomes...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28267190/changes-in-joint-contact-mechanics-in-a-large-quadrupedal-animal-model-after-partial-meniscectomy-and-a-focal-cartilage-injury
#12
David J Heckelsmiller, M James Rudert, Thomas E Baer, Douglas R Pedersen, Douglas C Fredericks, Jessica E Goetz
Acute mechanical damage and the resulting joint contact abnormalities are central to the initiation and progression of post-traumatic osteoarthritis (PTOA). Study of PTOA is typically performed in vivo with replicate animals using artificially induced injury features. The goal of this work was to measure changes in a joint contact stress in the knee of a large quadruped after creation of a clinically realistic overload injury and a focal cartilage defect. Whole-joint overload was achieved by excising a 5-mm wedge of the anterior medial meniscus...
May 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28255568/association-between-lateral-posterior-tibial-slope-body-mass-index-and-acl-injury-risk
#13
Katherine M Bojicic, Mélanie L Beaulieu, Daniel Y Imaizumi Krieger, James A Ashton-Miller, Edward M Wojtys
BACKGROUND: While body mass index (BMI), a modifiable parameter, and knee morphology, a nonmodifiable parameter, have been identified as risk factors for anterior cruciate ligament (ACL) rupture, the interaction between them remains unknown. An understanding of this interaction is important because greater compressive axial force (perhaps due to greater BMI) applied to a knee that is already at an increased risk because of its geometry, such as a steep lateral posterior tibial slope, could further increase the probability of ACL injury...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28251262/one-stage-revision-acl-reconstruction-after-primary-acl-double-bundle-reconstruction-is-bone-patella-tendon-bone-autograft-reliable
#14
Tomohiro Tomihara, Yusuke Hashimoto, Masatoshi Taniuchi, Junsei Takigami, Changhun Han, Nagakazu Shimada
PURPOSE: The purpose of this study is to assess the results of revision anterior cruciate ligament (ACL) reconstruction after the failure of primary ACL double bundle reconstruction (ACL-DBR). METHODS: Twenty-two knees in 22 patients (group R) that underwent ACL revision surgery using bone-patellar tendon-bone (BTB) autograft after the failure of primary ACL-DBR were included in this study. Intraoperative findings and postoperative knee laxity and clinical outcomes in group R were assessed...
March 1, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28244303/autologous-chondrocyte-implantation-in-the-knee-systematic-review-and-economic-evaluation
#15
Hema Mistry, Martin Connock, Joshua Pink, Deepson Shyangdan, Christine Clar, Pamela Royle, Rachel Court, Leela C Biant, Andrew Metcalfe, Norman Waugh
BACKGROUND: The surfaces of the bones in the knee are covered with articular cartilage, a rubber-like substance that is very smooth, allowing frictionless movement in the joint and acting as a shock absorber. The cells that form the cartilage are called chondrocytes. Natural cartilage is called hyaline cartilage. Articular cartilage has very little capacity for self-repair, so damage may be permanent. Various methods have been used to try to repair cartilage. Autologous chondrocyte implantation (ACI) involves laboratory culture of cartilage-producing cells from the knee and then implanting them into the chondral defect...
February 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28243954/knee-cartilage-regeneration-with-umbilical-cord-mesenchymal-stem-cells-embedded-in-collagen-scaffold-using-dry-arthroscopy-technique
#16
B Sadlik, G Jaroslawski, D Gladysz, M Puszkarz, M Markowska, K Pawelec, D Boruczkowski, T Oldak
Articular cartilage injuries lead to progressive degeneration of the joint with subsequent progression to osteoarthritis, which currently becomes a serious health and economic issue. Due to limited capability for self-regeneration, cartilage repair remains a challenge for the present-day orthopedics. Currently, available therapeutic methods fail to provide satisfactory results. A search for other strategies that could regenerate a hyaline-like tissue with a durable effect and adequate mechanical properties is underway...
February 28, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28240703/physical-activity-is-related-with-cartilage-quality-in-women-with-knee-osteoarthritis
#17
Matti Munukka, Benjamin Waller, Arja Häkkinen, Miika T Nieminen, Eveliina Lammentausta, Urho M Kujala, Juha Paloneva, Hannu Kautiainen, Ilkka Kiviranta, Ari Heinonen
PURPOSE: To study the relationship between 12-month leisure-time physical activity (LTPA) level and changes in estimated biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). METHODS: Originally 87 volunteer postmenopausal women, aged 60-68 years, with mild knee OA (Kellgren Lawrence I/II and knee pain) participated in a randomised controlled, 4-month aquatic training trial (RCT), after which 76 completed the 12-month post-intervention follow-up period...
February 25, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28238962/a-new-aiming-guide-can-create-the-tibial-tunnel-at-favorable-position-in-transtibialpullout-repair-for-the-medial-meniscus-posterior-root-tear
#18
Takayuki Furumatsu, Yuya Kodama, Masataka Fujii, Takaaki Tanaka, Tomohito Hino, Yusuke Kamatsuki, Kazuki Yamada, Shinichi Miyazawa, Toshifumi Ozaki
INTRODUCTION: Injuries to the medial meniscus (MM) posterior root lead to accelerated cartilage degeneration of the knee. An anatomic placement of the MM posterior root attachment is considered to be critical in transtibial pullout repair of the medial meniscus posterior root tear (MMPRT). However, tibial tunnel creation at the anatomic attachment of the MM posterior root is technically difficult using a conventional aiming device. The aim of this study was to compare two aiming guides...
February 23, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28213953/the-effects-of-acl-graft-placement-on-in-vivo-knee-function-and-cartilage-thickness-distributions
#19
REVIEW
Louis E DeFrate
Injuries to the anterior cruciate ligament (ACL) frequently lead to early-onset osteoarthritis. Despite advancement in surgical techniques, ACL reconstruction has a limited ability to prevent these degenerative changes. While previous studies have investigated knee function after ACL reconstruction, in vivo investigations of the effects of graft placement on in vivo joint function and cartilage health are limited. This review presents a series of studies that used novel imaging and 3D modeling techniques to determine the in vivo placement of the ACL graft on the femur using two different ACL reconstruction techniques...
February 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28211591/magnetic-resonance-imaging-of-the-knee-an-overview-and-update-of-conventional-and-state-of-the-art-imaging
#20
Nicholas C Nacey, Matthew G Geeslin, Grady Wilson Miller, Jennifer L Pierce
Magnetic resonance imaging (MRI) has become the preferred modality for imaging the knee to show pathology and guide patient management and treatment. The knee is one of the most frequently injured joints, and knee pain is a pervasive difficulty that can affect all age groups. Due to the diverse pathology, complex anatomy, and a myriad of injury mechanisms of the knee, the MRI knee protocol and sequences should ensure detection of both soft tissue and osseous structures in detail and with accuracy. The knowledge of knee anatomy and the normal or injured MRI appearance of these key structures are critical for precise diagnosis...
February 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
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