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Knee cartilage injury

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https://www.readbyqxmd.com/read/27911285/the-relation-between-chondromalacia-patella-and-meniscal-tear-and-the-sulcus-angle-trochlear-depth-ratio-as-a-powerful-predictor
#1
Hatice Resorlu, Coskun Zateri, Gurdal Nusran, Ferdi Goksel, Nilufer Aylanc
PURPOSE: To investigate the relation between chondromalacia patella and the sulcus angle/trochlear depth ratio as a marker of trochlear morphology. In addition, we also planned to show the relationship between meniscus damage, subcutaneous adipose tissue thickness as a marker of obesity, patellar tilt angle and chondromalacia patella. METHODS: Patients with trauma, rheumatologic disease, a history of knee surgery and patellar variations such as patella alba and patella baja were excluded...
November 25, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27881381/two-year-outcomes-of-a-randomized-trial-investigating-a-6-week-return-to-full-weightbearing-after-matrix-induced-autologous-chondrocyte-implantation
#2
Jay R Ebert, Peter K Edwards, Michael Fallon, Timothy R Ackland, Gregory C Janes, David J Wood
BACKGROUND: Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging outcomes in treating patients with knee cartilage defects. Postoperatively, the time required to attain full weightbearing (WB) remains conservative. HYPOTHESIS: We hypothesized that patients would have no significant clinical or radiological differences or graft complications after an 8-week or 6-week return to full WB after MACI. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
November 23, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27876676/anatomical-region-dependent-enhancement-of-3-dimensional-chondrogenic-differentiation-of-human-mesenchymal-stem-cells-by-soluble-meniscus-extracellular-matrix
#3
Benjamin B Rothrauff, Kazunori Shimomura, Riccardo Gottardi, Peter G Alexander, Rocky S Tuan
: Extracellular matrix (ECM) derived from decellularized tissues has been found to promote tissue neogenesis, most likely mediated by specific biochemical and physical signaling motifs that promote tissue-specific differentiation of progenitor cells. Decellularized ECM has been suggested to be efficacious for the repair of tissue injuries. However, decellularized meniscus contains a dense collagenous structure, which impedes cell seeding and infiltration and is not readily applicable for meniscus repair...
November 19, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27871655/surgical-indications-and-technique-for-anterior-cruciate-ligament-reconstruction-combined-with-lateral-extra-articular-tenodesis-or-anterolateral-ligament-reconstruction
#4
REVIEW
Bart Vundelinckx, Benjamin Herman, Alan Getgood, Robert Litchfield
After anterior cruciate ligament (ACL) rupture, anteroposterior and rotational laxity in the knee causes instability, functional symptoms, and damage to other intra-articular structures. Surgical reconstruction aims to restore the stability in the knee, and to improve function and ability to participate in sports. It also protects cartilage and menisci from secondary injuries. Because of persistent rotational instability after ACL reconstruction, combined intra-articular and extra-articular procedures are more commonly performed...
January 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27869622/acl-deficiency-increases-forces-on-the-medial-femoral-condyle-and-the-lateral-meniscus-with-applied-rotatory-loads
#5
Lucas S McDonald, James Boorman-Padgett, Robert Kent, Kyle Stone, Thomas L Wickiewicz, Andrew D Pearle, Carl W Imhauser
BACKGROUND: The articular surfaces and menisci act with the anterior cruciate ligament (ACL) to stabilize the knee joint. Their role in resisting applied rotatory loads characteristic of instability events is unclear despite commonly observed damage to these intra-articular structures in the acute and chronic ACL injury settings. METHODS: Ten fresh-frozen human cadaveric knees were mounted to a robotic manipulator. Combined valgus and internal rotation torques were applied in the presence and absence of a 300-N compressive load...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27847384/parathyroid-hormone-induced-bone-marrow-mesenchymal-stem-cell-chondrogenic-differentiation-and-its-repair-of-articular-cartilage-injury-in-rabbits
#6
Yushu Chen, Yi Chen, Shujiang Zhang, Xiufan Du, Bo Bai
BACKGROUND We explored the effect of parathyroid hormone (PTH)-induced bone marrow stem cells (BMSCs) complexed with fibrin glue (FG) in the repair of articular cartilage injury in rabbits. MATERIAL AND METHODS Forty-eight rabbits randomized into four groups were subjected to articular surgery (cartilage loss). The PTH and non-PTH intervention groups included transplantation with PTH/BMSC/FG xenogeneic and BMSC/FG xenogeneic complexes, respectively, into the injured area. The injured group contained no transplant while the control group comprised rabbits without any articular injury...
November 16, 2016: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/27846352/-risk-factors-and-frequency-in-re-ruptures-of-the-anterior-cruciate-ligament-in-adults
#7
M L Velázquez-Rueda, J P Martínez-Ávila, A G Pérez-Serna, F Gómez-García
BACKGROUND: The anterior cruciate ligament (ACL) takes part in the knees articular cinematic regulation, which is why its rupture should be repaired as soon as possible. The surgical treatment is targeted to substitute the ruptured ACL with a graft that recreates the anatomical and biomechanical functions. Nevertheless, there are different factors that may produce a second rupture. OBJECTIVE: To determine the risk factors and frequency of failure in the ACL reconstruction...
March 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27824492/evolution-of-intrameniscal-signal-intensity-alterations-detected-on-mri-over-24-months-in-patients-with-traumatic-anterior-cruciate-ligament-tear
#8
Julio Brandao Guimaraes, Luca Facchetti, Benedikt J Schwaiger, Alexandra S Gersing, Sharmila Majumdar, Benjamin C Ma, Xiaojuan Li, Thomas M Link
OBJECTIVE: The objective of our study was to assess the prevalence and evolution of intrameniscal signal-intensity alteration in subjects with an anterior cruciate ligament (ACL) tear over 24 months and compare clinical outcome and changes of cartilage between subjects with and those without this meniscal abnormality. MATERIALS AND METHODS: Fifty-seven subjects with an ACL tear were screened for intrameniscal signal-intensity alteration. Morphologic and compositional MRI was performed before ACL reconstruction and 12 and 24 months after ACL reconstruction...
November 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27818975/effect-of-muscle-contractions-on-cartilage-morphological-and-functional-magnetic-resonance-imaging-evaluation-of-the-knee-after-spinal-cord-injury
#9
Marco Kawamura Demange, Camilo Partezani Helito, Paulo Victor Partezani Helito, Felipe Ferreira de Souza, Riccardo Gomes Gobbi, Alexandre Fogaça Cristante
OBJECTIVE: To evaluate the effect of complete absence of muscle contractions on normal human cartilage in the presence of joint motion. METHODS: Patients with complete acute spinal cord injuries were enrolled. All patients underwent magnetic resonance imaging (MRI) on both knees as soon as their medical condition was stable and at six months after the primary lesion. All patients received rehabilitation treatment that included lower-limb passive motion exercises twice a day...
September 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27813166/characteristics-of-meniscus-progenitor-cells-migrated-from-injured-meniscus
#10
Dongrim Seol, Cheng Zhou, Marc J Brouillette, Ino Song, Yin Yu, Hyeong Hun Choe, Abigail D Lehman, Kee W Jang, Douglas C Fredericks, Barbara J Laughlin, James A Martin
Serious meniscus injuries seldom heal and increase the risk for knee osteoarthritis; thus, there is a need to develop new reparative therapies. In that regard, stimulating tissue regeneration by autologous stem/progenitor cells has emerged as a promising new strategy. We showed previously that migratory chondrogenic progenitor cells (CPCs) were recruited to injured cartilage, where they showed a capability in situ tissue repair. Here, we tested the hypothesis that the meniscus contains a similar population of regenerative cells...
November 3, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27811513/patellofemoral-pain-and-instability-in-adolescent-athletes
#11
Matthew Bessette, Paul Saluan
Injuries and disorders of the patellofemoral joint in the adolescent athlete can encompass a wide spectrum of symptomatology and pathology. Anterior knee pain is a common presenting symptom in sports medicine clinics, and can have numerous underlying etiologies. This activity-related pain may be the manifestation of enthesopathy, tendinopathy, fat pad impingement, or numerous other conditions, but is more commonly related to more subtle skeletal and muscular imbalances. Treatment is typically nonoperative in nature, and excellent results are reported with physical therapy...
December 2016: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/27803940/association-between-meniscal-and-chondral-lesions-and-timing-of-anterior-cruciate-ligament-reconstruction
#12
Gustavo Constantino de Campos, Wilton Nery, Paulo Eduardo Portes Teixeira, Paulo Henrique Araujo, Wilson de Mello Alves
BACKGROUND: Rupture of the anterior cruciate ligament (ACL) is a common sports injury and is known to be associated with an increased risk of knee osteoarthritis. Several studies have indicated that the risk of additional injuries to the menisci and articular cartilage increases with delays in the treatment of ACL tears. However, no consensus has been reached regarding the ideal timing for ACL reconstruction in terms of preventing secondary lesions. PURPOSE: To determine how the time elapsed between an ACL lesion and its reconstruction affects the incidence of meniscal and chondral lesions...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27802963/does-the-chronicity-of-anterior-cruciate-ligament-ruptures-influence-patient-reported-outcomes-before-surgery
#13
Joseph T Nguyen, David Wasserstein, Emily K Reinke, Kurt P Spindler, Nabil Mehta, John B Doyle, Robert G Marx
BACKGROUND: The time between an anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) may influence baseline knee-related and general health-related patient-reported outcome measures (PROMs). Despite the common use of PROMs as main outcomes in clinical studies, this variable has never been evaluated. PURPOSE: To compare baseline health-related quality of life measures and the prevalence/pattern of meniscal and articular cartilage lesions between patients who underwent acute and chronic ACLR so as to provide clinicians with benchmark PROMs in 2 different patient populations with ACL injuries...
November 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27798972/signs-of-knee-osteoarthritis-common-in-620-patients-undergoing-arthroscopic-surgery-for-meniscal-tear
#14
Kenneth Pihl, Martin Englund, L Stefan Lohmander, Uffe Jørgensen, Nis Nissen, Jeppe Schjerning, Jonas B Thorlund
Background and purpose - Recent evidence has questioned the effect of arthroscopic knee surgery for middle-aged and older patients with degenerative meniscal tears with or without concomitant radiographic knee osteoarthritis (OA). We investigated the prevalence of early or more established knee OA and patients' characteristics in a cohort of patients undergoing arthroscopic surgery for a meniscal tear. Patients and methods - 641 patients assigned for arthroscopy on suspicion of meniscus tear were consecutively recruited from February 2013 through January 2015...
November 1, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27797605/quantitative-histological-grading-methods-to-assess-subchondral-bone-and-synovium-changes-subsequent-to-medial-meniscus-transection-in-the-rat
#15
Heidi E Kloefkorn, Kyle D Allen
AIM OF THE STUDY: The importance of the medial meniscus to knee health is demonstrated by studies which show meniscus injuries significantly increase the likelihood of developing osteoarthritis (OA), and knee OA can be modeled in rodents using simulated meniscus injuries. Traditionally, histological assessments of OA in these models have focused on damage to the articular cartilage; however, OA is now viewed as a disease of the entire joint as an organ system. The aim of this study was to develop quantitative histological measures of bone and synovial changes in a rat medial meniscus injury model of knee OA...
October 31, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27796082/pet-mri-of-metabolic-activity-in-osteoarthritis-a-feasibility-study
#16
Feliks Kogan, Audrey P Fan, Emily J McWalter, Edwin H G Oei, Andrew Quon, Garry E Gold
PURPOSE: To evaluate positron emission tomography / magnetic resonance imaging (PET/MRI) knee imaging to detect and characterize osseous metabolic abnormalities and correlate PET radiotracer uptake with osseous abnormalities and cartilage degeneration observed on MRI. MATERIALS AND METHODS: Both knees of 22 subjects with knee pain or injury were scanned at one timepoint, without gadolinium, on a hybrid 3.0T PET-MRI system following injection of (18) F-fluoride or (18) F-fluorodeoxyglucose (FDG)...
October 31, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27789021/nasal-chondrocyte-based-engineered-autologous-cartilage-tissue-for-repair-of-articular-cartilage-defects-an-observational-first-in-human-trial
#17
Marcus Mumme, Andrea Barbero, Sylvie Miot, Anke Wixmerten, Sandra Feliciano, Francine Wolf, Adelaide M Asnaghi, Daniel Baumhoer, Oliver Bieri, Martin Kretzschmar, Geert Pagenstert, Martin Haug, Dirk J Schaefer, Ivan Martin, Marcel Jakob
BACKGROUND: Articular cartilage injuries have poor repair capacity, leading to progressive joint damage, and cannot be restored predictably by either conventional treatments or advanced therapies based on implantation of articular chondrocytes. Compared with articular chondrocytes, chondrocytes derived from the nasal septum have superior and more reproducible capacity to generate hyaline-like cartilage tissues, with the plasticity to adapt to a joint environment. We aimed to assess whether engineered autologous nasal chondrocyte-based cartilage grafts allow safe and functional restoration of knee cartilage defects...
October 22, 2016: Lancet
https://www.readbyqxmd.com/read/27782728/automatic-segmentation-of-the-glenohumeral-cartilages-from-magnetic-resonance-images
#18
A Neubert, Z Yang, C Engstrom, Y Xia, M W Strudwick, S S Chandra, J Fripp, S Crozier
PURPOSE: Magnetic resonance (MR) imaging plays a key role in investigating early degenerative disorders and traumatic injuries of the glenohumeral cartilages. Subtle morphometric and biochemical changes of potential relevance to clinical diagnosis, treatment planning, and evaluation can be assessed from measurements derived from in vivo MR segmentation of the cartilages. However, segmentation of the glenohumeral cartilages, using approaches spanning manual to automated methods, is technically challenging, due to their thin, curved structure and overlapping intensities of surrounding tissues...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27766275/quantifying-quadriceps-muscle-strength-in-patients-with-acl-injury-focal-cartilage-lesions-and-degenerative-meniscus-tears-differences-and-clinical-implications
#19
Ingrid Eitzen, Hege Grindem, Agnethe Nilstad, Håvard Moksnes, May Arna Risberg
BACKGROUND: Reduced quadriceps strength influences knee function and increases the risk of knee osteoarthritis. Thus, it is of significant clinical relevance to precisely quantify strength deficits in patients with knee injuries. PURPOSE: To evaluate isokinetic concentric quadriceps muscle strength torque values, assessed both from peak torque and at specific knee flexion joint angles, in patients with anterior cruciate ligament (ACL) injury, focal cartilage lesions, and degenerative meniscus tears...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27757290/bipartite-patella-in-35-year-old-fitness-instructor-a-case-report
#20
Sebastian Zabierek, Jakub Zabierek, Adam Kwapisz, Marcin E Domzalski
BACKGROUND AND PURPOSE: The patella plays an important role in knee biomechanics and provides anterior coverage of the knee joint. One to two percent of the population has an anatomical variant of patella called a bipartite patella that usually does not case pain. However, occasionally after injury or overuse during sport it can be a source of anterior knee pain. The purpose of this case report was to present a rare variant of bipartite patella and highlight conservative treatment of this condition...
October 2016: International Journal of Sports Physical Therapy
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