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Knee cartilage injury

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https://www.readbyqxmd.com/read/28526923/focal-articular-prosthetic-resurfacing-for-the-treatment-of-full-thickness-articular-cartilage-defects-in-the-knee-12-year-follow-up-of-two-cases-and-review-of-the-literature
#1
C Becher, E B Cantiller
INTRODUCTION: The rationale of focal articular prosthetic resurfacing used as a primary arthroplasty procedure in the treatment of articular cartilage defects is still under debate. Conflicting reports raise concern about high rates of re-operations and continued development of osteoarthritis, while others have reported good outcomes. The goal of this paper is to present the long-term results of two patients with a 12-year follow-up and to report the results of a literature review. MATERIALS AND METHODS: Two patients (male, 70 years; female 63 years) with a follow-up of 12 years were reviewed...
May 19, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28520463/a-preclinical-assessment-of-early-continuous-passive-motion-and-treadmill-therapeutic-exercises-for-generating-chondroprotective-effects-after-anterior-cruciate-ligament-rupture
#2
Nai-Jen Chang, Kuan-Wei Lee, Chih-Jou Chu, Ming-You Shie, Pei-Hsi Chou, Chih-Chan Lin, Peir-In Liang
BACKGROUND: Anterior cruciate ligament (ACL) injury is a well-known risk factor for the development of posttraumatic osteoarthritis (PTOA). However, whether using continuous passive motion (CPM) with or without additional treadmill exercise (TRE) in early ACL injury might provide chondroprotective effects and further decrease the risk of PTOA has yet to be determined. HYPOTHESIS: CPM may offer an enhanced chondroprotective effect, but TRE may attenuate that effect due to the mechanical stress on the joint and inflammatory cytokines in the joint...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28516106/a-cost-effectiveness-analysis-of-surgical-treatment-modalities-for-chondral-lesions-of-the-knee-microfracture-osteochondral-autograft-transplantation-and-autologous-chondrocyte-implantation
#3
REVIEW
John B Schrock, Matthew J Kraeutler, Darby A Houck, Matthew B McQueen, Eric C McCarty
BACKGROUND: Numerous surgical options exist to treat chondral lesions in the knee, including microfracture (MFx), osteochondral autograft transplantation (OAT), first-generation autologous chondrocyte implantation (ACI-1), and next-generation ACI (ACI-2). PURPOSE: To compare the cost-effectiveness of MFx, OAT, and ACI-1. The secondary purpose of this study was to compare the functional outcomes of MFx, OAT, ACI-1, and ACI-2. STUDY DESIGN: Systematic review; Level of evidence, 2...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28515057/delaying-acl-reconstruction-and-treating-with-exercise-therapy-alone-may-alter-prognostic-factors-for-5-year-outcome-an-exploratory-analysis-of-the-kanon-trial
#4
Stephanie R Filbay, Ewa M Roos, Richard B Frobell, Frank Roemer, Jonas Ranstam, L Stefan Lohmander
AIM: Identify injury-related, patient-reported and treatment-related prognostic factors for 5-year outcomes in acutely ACL-ruptured individuals managed with early reconstruction plus exercise therapy, exercise therapy plus delayed reconstruction or exercise therapy alone. METHODS: Exploratory analysis of the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) trial (ISRCTN84752559). Relationships between prognostic factors (baseline cartilage, meniscus and osteochondral damage, baseline extension deficit, baseline patient-reported outcomes, number of rehabilitation visits, graft/contralateral ACL rupture, non-ACL surgery and ACL treatment strategy) and 5-year Knee Injury and Osteoarthritis Outcome Score (KOOS) pain, symptoms, sport/recreation and quality of life (QOL) scores were explored using multivariable linear regression...
May 17, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28507957/arthroscopic-synovectomy-in-bilateral-lipoma-arborescens
#5
Paolo Fornaciari, Pascal A Schai, Michael O Kurrer, G Ulrich Exner
INTRODUCTION: Lipoma arborescens (LA) is an uncommon condition that consists of a villous lipomatous proliferation of the synovial membrane. Open synovectomy has been previously selected as a curative treatment option. In recent years, some authors have published good results with arthroscopic interventions. We describe a well-documented case of bilateral LA of the knees treated with staged arthroscopic synovectomy. CASE REPORT: A 48-year-old North American woman without a history of trauma presented with recurrent effusions and mild pain in both knee joints for many years...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28488835/incidence-of-injury-and-illness-in-south-african-professional-male-football-players-a-prospective-cohort-study
#6
Helen Bayne, Martin Schwellnus, Dina Janse Van Rensburg, Jhano Botha, Lervasen Pillay
BACKGROUND: Medical illnesses and sports-related injuries both have an effect on athlete health and performance. Epidemiology of injury and illness has been extensively researched during international football tournaments and the European football season. Reports on injury location and severity differ across geographical regions, and there is limited information on injury epidemiology in African football leagues. No studies have investigated the illness burden in football in Africa. METHODS: This was a prospective cohort study involving two football teams over the 10- month duration of the 2015/16 Premier Soccer League in South Africa...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28469288/friction-properties-of-a-new-silk-fibroin-scaffold-for-meniscal-replacement
#7
Daniela Warnecke, N B Schild, S Klose, H Joos, R E Brenner, O Kessler, N Skaer, R Walker, M Freutel, A Ignatius, L Dürselen
The menisci protect the articular cartilage by reducing contact pressure in the knee. To restore their function after injury, a new silk fibroin replacement scaffold was developed. To elucidate its tribological properties, friction of the implant was tested against cartilage and glass, where the latter is typically used in tribological cartilage studies. The silk scaffold exhibited a friction coefficient against cartilage of 0.056, which is higher than meniscus against cartilage but in range of the requirements for meniscal replacements...
May 2017: Tribology International
https://www.readbyqxmd.com/read/28463576/advances-in-application-of-mechanical-stimuli-in-bioreactors-for-cartilage-tissue-engineering
#8
Ke Li, Chunqiu Zhang, Lulu Qiu, Lilan Gao, Xizheng Zhang
Articular cartilage (AC) is the weight-bearing tissue in diarthroses. It lacks the capacity for self-healing once there are injuries or diseases due to its avascularity. With the development of tissue engineering, repairing cartilage defects through transplantation of engineered cartilage that closely matches properties of native cartilage has become a new option for curing cartilage diseases. The main hurdle for clinical application of engineered cartilage is how to develop functional cartilage constructs for mass production in a credible way...
May 24, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28452204/mesenchymal-stem-cells-time-to-change-the-name
#9
Arnold I Caplan
Mesenchymal stem cells (MSCs) were officially named more than 25 years ago to represent a class of cells from human and mammalian bone marrow and periosteum that could be isolated and expanded in culture while maintaining their in vitro capacity to be induced to form a variety of mesodermal phenotypes and tissues. The in vitro capacity to form bone, cartilage, fat, etc., became an assay for identifying this class of multipotent cells and around which several companies were formed in the 1990s to medically exploit the regenerative capabilities of MSCs...
June 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28451623/accelerated-return-to-sport-after-osteochondral-autograft-plug-transfer
#10
Brian C Werner, Chris T Cosgrove, C Jan Gilmore, Matthew L Lyons, Mark D Miller, Stephen F Brockmeier, David R Diduch
BACKGROUND: Previous studies have reported varying return-to-sport protocols after knee cartilage restoration procedures. PURPOSE: To (1) evaluate the time for return to sport in athletes with an isolated chondral injury who underwent an accelerated return-to-sport protocol after osteochondral autograft plug transfer (OAT) and (2) evaluate clinical outcomes to assess for any consequences from the accelerated return to sport. STUDY DESIGN: Case series; Level of evidence, 4...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28451604/open-reduction-internal-fixation-of-isolated-chondral-fragments-without-osseous-attachment-in-the-knee-a-case-series
#11
Patrick N Siparsky, James R Bailey, Kevin M Dale, Mitchell R Klement, Dean C Taylor
BACKGROUND: Isolated chondral fractures of the knee are a rare and challenging problem, typically occurring with an acute traumatic event such as dislocation of the patella or ligamentous injury. Historically, repair of unstable chondral fragments without osseous attachment has not been recommended due to concerns about the limited healing potential of cartilage. PURPOSE: To describe a technique for fixation of large isolated chondral fractures of the knee and present 3 cases where large chondral fragments without osseous attachment were fixed successfully with chondral darts and biologic adhesive...
March 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28438606/cell-origin-volume-and-arrangement-are-drivers-of-articular-cartilage-formation-morphogenesis-and-response-to-injury-in-mouse-limbs
#12
Rebekah S Decker, Hyo-Bin Um, Nathaniel A Dyment, Naiga Cottingham, Yu Usami, Motomi Enomoto-Iwamoto, Mark S Kronenberg, Peter Maye, David W Rowe, Eiki Koyama, Maurizio Pacifici
Limb synovial joints are composed of distinct tissues, but it is unclear which progenitors produce those tissues and how articular cartilage acquires its functional postnatal organization characterized by chondrocyte columns, zone-specific cell volumes and anisotropic matrix. Using novel Gdf5(CreERT2) (Gdf5-CE), Prg4-CE and Dkk3-CE mice mated to R26-Confetti or single-color reporters, we found that knee joint progenitors produced small non-migratory progenies and distinct local tissues over prenatal and postnatal time...
April 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28437755/an-in-vitro-study-of-cartilage-meniscus-tribology-to-understand-the-changes-caused-by-a-meniscus-implant
#13
Sara Ehsani Majd, Aditya Iman Rizqy, Hans J Kaper, Tannin A Schmidt, Roel Kuijer, Prashant K Sharma
Active lifestyles increase the risk of meniscal injury. A permanent meniscus implant of polycarbonate urethane (PCU) is a promising treatment to postpone/prevent total knee arthroplasty. Study of the changes in articular cartilage tribology in the presence of PCU is essential in developing the optimum meniscus implant. Therefore, a cartilage-meniscus reciprocating, sliding model was developed in vitro, mimicking the stance and swing phases of the gait cycle. The meniscus was further replaced with PCU and surface-modified PCUs (with C18 chains, mono-functional polydimethylsiloxane groups and mono-functional polytetrafluoroethylene groups) to study the changes...
April 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28425824/isolated-acl-versus-multiple-knee-ligament-injury-associations-with-patient-characteristics-cartilage-status-and-meniscal-tears-identified-during-acl-reconstruction
#14
Ronald W B Wyatt, Maria C S Inacio, Kate D Bellevue, Alan L Schepps, Gregory B Maletis
OBJECTIVES: The objectives of this study were to determine (1) if patients undergoing reconstruction of an isolated anterior cruciate ligament (ACL) tear had different characteristics (age, gender, body mass index [BMI]) than patients undergoing ACL reconstruction (ACLR) with multiple knee ligament (MKL) tears and (2) whether there was a difference in prevalence of articular cartilage injury and meniscus tears between these two groups. METHODS: Patients undergoing primary ACLR between February 2005 and June 2013 were identified through an ACLR registry...
May 4, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28423287/microfracture-versus-autologous-chondrocyte-implantation-for-articular-cartilage-lesions-in-the-knee-a-systematic-review-of-5-year-outcomes
#15
Matthew J Kraeutler, John W Belk, Justin M Purcell, Eric C McCarty
BACKGROUND: Microfracture (MFx) and autologous chondrocyte implantation (ACI) are 2 surgical treatment options used to treat articular cartilage injuries of the knee joint. PURPOSE: To compare the midterm to long-term clinical outcomes of MFx versus ACI for focal chondral defects of the knee. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to locate studies (level of evidence I-III) comparing the minimum average 5-year clinical outcomes of patients undergoing MFx versus ACI...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28419808/outcomes-after-1-stage-versus-2-stage-revision-anterior-cruciate-ligament-reconstruction
#16
Justin J Mitchell, Jorge Chahla, Chase S Dean, Mark Cinque, Lauren M Matheny, Robert F LaPrade
BACKGROUND: Revision anterior cruciate ligament reconstruction (ACLR) is becoming increasingly common as the number of primary ACLR cases continues to rise. Despite this, there are limited data on the outcomes of revision ACLR and even less information specifically addressing the differences in 1-stage revision reconstruction versus those performed in a 2-stage fashion after primary reconstruction. PURPOSE: To compare the outcomes, patient satisfaction, and failure rates of 1-stage versus 2-stage revision ACLR...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28411451/anisotropic-tough-double-network-hydrogel-from-fish-collagen-and-its-spontaneous-in%C3%A2-vivo-bonding-to-bone
#17
Md Tariful Islam Mredha, Nobuto Kitamura, Takayuki Nonoyama, Susumu Wada, Keiko Goto, Xi Zhang, Tasuku Nakajima, Takayuki Kurokawa, Yasuaki Takagi, Kazunori Yasuda, Jian Ping Gong
Soft supporting tissues in the human body, such as cartilages and ligaments, are tough materials and firmly fixed to bones. These soft tissues, once injured, cannot regenerate spontaneously in vivo. Developing tough and biocompatible hydrogels as artificial soft supporting tissues would substantially improve outcomes after soft tissue injury. Collagen is the main rigid component in soft connective tissues which is organized in various hierarchical arrays. We have successfully developed a novel class of collagen fibril-based tough hydrogels based on the double network (DN) concept using swim bladder collagen (SBC) extracted from Bester sturgeon fish...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28406954/therapeutic-efficacy-of-intra-articular-hyaluronan-derivative-and-platelet-rich-plasma-in-mice-following-axial-tibial-loading
#18
Xin Duan, Linda J Sandell, Nobuaki Chinzei, Nilsson Holguin, Matthew J Silva, Antonella Schiavinato, Muhammad Farooq Rai
OBJECTIVE: To investigate the therapeutic potential of intra-articular hyaluronan-derivative HYADD® 4-G and/or platelet-rich plasma (PRP) in a mouse model of non-invasive joint injury. METHODS: Non-invasive axial tibial loading was used to induce joint injury in 10-week-old C57BL/6J mice (n = 86). Mice underwent a single loading of either 6 Newton (N) or 9N axial tibial compression. HYADD® 4-G was injected intra-articularly at 8 mg/mL or 15 mg/mL either before or after loading with or without PRP...
2017: PloS One
https://www.readbyqxmd.com/read/28406879/physical-examination-of-the-knee-meniscus-cartilage-and-patellofemoral-conditions
#19
Robert D Bronstein, Joseph C Schaffer
The knee is one of the most commonly injured joints in the body. Its superficial anatomy enables diagnosis of the injury through a thorough history and physical examination. Examination techniques for the knee described decades ago are still useful, as are more recently developed tests. Proper use of these techniques requires understanding of the anatomy and biomechanical principles of the knee as well as the pathophysiology of the injuries, including tears to the menisci and extensor mechanism, patellofemoral conditions, and osteochondritis dissecans...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28400662/early-anterior-cruciate-ligament-reconstruction-can-save-meniscus-without-any-complications
#20
Chang-Ik Hur, Eun-Kyoo Song, Sung-Kyu Kim, Seung-Hun Lee, Jong-Keun Seon
BACKGROUND: Early ACL reconstruction, before retuning to activity eliminates recurrent episodes of instability and thereby decreases chances of meniscal and cartilage injury. However, there are no clear and uniform guidelines regarding the timing of ACL reconstruction or clarity in the definition of early and delayed reconstruction to reduce the complications after reconstruction in the ACL injured knee. The purpose of this study was to compare the clinical outcome, stability, muscle power, and postural control after early and delayed anterior cruciate ligament (ACL) reconstruction...
March 2017: Indian Journal of Orthopaedics
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