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Knee cartilage injury

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https://www.readbyqxmd.com/read/29780834/factors-affecting-the-achievement-of-a-patient-acceptable-symptom-state-1-year-after-anterior-cruciate-ligament-reconstruction-a-cohort-study-of-343-patients-from-2-registries
#1
Eric Hamrin Senorski, Eleonor Svantesson, Susanne Beischer, Alberto Grassi, Ferid Krupic, Roland Thomeé, Kristian Samuelsson
Background: There is insufficient knowledge regarding the influence of concomitant injuries on the recovery of short-term subjective knee function after anterior cruciate ligament (ACL) reconstruction. Purpose: To determine whether patient characteristics, concomitant injuries, and graft choice during ACL reconstruction can predict which patients achieve acceptable knee function 1 year after reconstruction. Study Design: Case-control study; Level of evidence, 3...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29768019/does-anterior-cruciate-ligament-reconstruction-affect-the-outcome-of-osteochondral-allograft-transplantation-a-matched-cohort-study-with-a-mean-follow-up-of-6-years
#2
Luís E P Tírico, Julie C McCauley, Pamela A Pulido, William D Bugbee
BACKGROUND: Few studies have evaluated the influence of anterior cruciate ligament (ACL) reconstruction on the outcome of cartilage repair. Hypothesis/Purpose: The purpose was to investigate the association between ACL reconstruction and functional outcomes after osteochondral allograft (OCA) transplantation. The hypothesis was that patients treated with OCA transplantation who had a history of ACL reconstruction would have inferior clinical outcomes and lower osteochondral graft survivorship when compared with a matched group of patients undergoing OCA transplantation without a history of ACL reconstruction...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29762847/effects-of-fibroblast-growth-factors-2-and-low-intensity-pulsed-ultrasound-on-the-repair-of-knee-articular-cartilage-in-rabbits
#3
Z-F Tang, H-Y Li
OBJECTIVE: To investigate the effect of low intensity ultrasound irradiation combine with fibroblast growth factors (FGF2) on the repair of the knee articular cartilage and to explore its mechanism in rabbit. MATERIALS AND METHODS: The model of the rabbit knee joint injury was established. 40 rabbits were divided into four groups, including control group, model group, FGF2 group and FGF2 + low intensity pulsed ultrasound group (FGF2 + LIPU). The knee joints of rabbits were taken at 4 and 8 weeks, respectively...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29761549/sprifermin-treatment-enhances-cartilage-integration-in-an-in-vitro-repair-model
#4
Mackenzie L Sennett, Gregory R Meloni, Alexandra J E Farran, Hans Guehring, Robert L Mauck, George R Dodge
Cartilage integration remains a clinical challenge for treatment of focal articular defects. Cartilage exhibits limited healing capacity that declines with tissue maturation. Many approaches have been investigated for their ability to stimulate healing of mature cartilage or integration of repair tissue or tissue-engineered constructs with native cartilage. Growth factors present in immature tissue may enhance chondrogenesis and promote integrative repair of cartilage defects. In this study, we assessed the role of one such factor, fibroblast growth factor 18 (FGF18)...
May 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29752053/anterior-laxity-lateral-tibial-slope-and-in-situ-acl-force-differentiate-knees-exhibiting-distinct-patterns-of-motion-during-a-pivoting-event-a-human-cadaveric-study
#5
Robert N Kent, Mark J Amirtharaj, Brendan M Hardy, Andrew D Pearle, Thomas L Wickiewicz, Carl W Imhauser
Knee instability following anterior cruciate ligament (ACL) rupture compromises function and increases risk of injury to the cartilage and menisci. To understand the biomechanical function of the ACL, previous studies have primarily reported the net change in tibial position in response to multiplanar torques, which generate knee instability. In contrast, we retrospectively analyzed a cohort of 13 consecutively tested cadaveric knees and found distinct motion patterns, defined as the motion of the tibia as it translates and rotates from its unloaded, initial position to its loaded, final position...
April 11, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29748965/subchondroplasty-for-the-treatment-of-post-traumatic-bone-marrow-lesions-of-the-medial-femoral-condyle-in-a-pre-clinical-canine-model
#6
Olubusola A Brimmo, Chantelle C Bozynski, Cristi R Cook, Keiichi Kuroki, Seth L Sherman, Ferris M Pfeiffer, Aaron M Stoker, James L Cook
This study characterizes long-term outcomes associated with subchondroplasty (SCP) treatment for impact-induced subchondral bone marrow lesions (BML) using a validated pre-clinical canine model. With IACUC approval, purpose-bred research hounds (n = 16) underwent arthroscopic impact injury (40N) to both medial femoral condyles. At 3 months, functional assessments, arthroscopy and MRI were performed and knees (n = 32) were randomly assigned to SCP (3 mL fluoroscopically guided percutaneous injection of AccuFill BSM into BML bone defects) or sham injection (Control)...
May 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29744321/morphology-of-intra-articular-structures-and-histology-of-menisci-of-knee-joint
#7
Monika Gupta, Parmod Kumar Goyal, Poonam Singh, Anu Sharma
Introduction: Menisci and cruciate ligaments are intra-articular structures of knee, and injury to these structures is common. Morphometric data gained in the study will help in analyzing the variations among humans and correlating it with the possibility, location, and type of injuries as well as better interpretation of structures during magnetic resonance imaging and arthroscopy which will further help in reconstructive surgeries of knee. Materials and Methods: Width and thickness of the medial menisci (MM), lateral menisci (LM), and maximum length and width of anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) were taken on twenty knees...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29739464/in-vivo-cartilage-tissue-engineering
#8
B Gurer, S Cabuk, O Karakus, N Yilmaz, C Yilmaz
BACKGROUND: Biologic treatment options for cartilage injuries require chondrocyte expansion using cell culture. Clinical application is accomplished in two surgical sessions and is expensive. If isolation of chondrocytes and stimulus for proliferation and extracellular matrix synthesis can be achieved in vivo, the treatment can be performed in one session and the cost can be reduced. METHODS: A 2.5-cm diameter full-thickness chondral defect was created in the knees of five groups of sheep...
May 8, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29731871/co-implantation-of-bone-marrow-mesenchymal-stem-cells-and-chondrocytes-increase-the-viability-of-chondrocytes-in-rat-osteo-chondral-defects
#9
Zhi Zhao, Xinshe Zhou, Jianzhong Guan, Min Wu, Jiansheng Zhou
Replacement of chondrocytes by adult stem cells was believed to improve the performance of autologous chondrocytes transplantation, since less chondrocytes were needed. Previous studies have demonstrated that the increased cartilage production in pellet co-cultures of chondrocytes and bone marrow mesenchymal stem cells (BMSCs) is due to the trophic effects of the MSC by stimulating chondrocyte proliferation and matrix production. However, the destination of MSCs or chondrocytes after implanted in osteo-chondral defects is not clear...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29730213/comparative-matched-pair-analysis-of-keyhole-bone-plug-technique-versus-arthroscopic-assisted-pullout-suture-technique-for-lateral-meniscal-allograft-transplantation
#10
Yong Gon Koh, Yong Sang Kim, Oh Ryong Kwon, Dong Beom Heo, Dae Hyun Tak
PURPOSE: To compare the clinical outcomes and meniscal extrusion measured by magnetic resonance imaging (MRI) between the keyhole bone-plug technique and arthroscopic-assisted pullout suture technique in lateral meniscal allograft transplantation (MAT). METHODS: Between October 2009 and February 2015, patients who underwent lateral MAT were retrospectively reviewed. The inclusion criteria were patients with symptomatic knees that had undergone total or subtotal meniscectomy who were treated with lateral MAT with a minimum follow-up period of 2 years...
May 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29717217/progression-of-post-traumatic-osteoarthritis-in-rat-meniscectomy-models-comprehensive-monitoring-using-mri
#11
Tonima S Ali, Indira Prasadam, Yin Xiao, Konstantin I Momot
Knee injury often triggers post-traumatic osteoarthritis (PTOA) that affects articular cartilage (AC), subchondral bone, meniscus and the synovial membrane. The available treatments for PTOA are largely ineffective due to late diagnosis past the "treatment window". This study aimed to develop a detailed understanding of the time line of the progression of PTOA in murine models through longitudinal observation of the femorotibial joint from the onset of the disease to the advanced stage. Quantitative magnetic resonance microimaging (µMRI) and histology were used to evaluate PTOA-associated changes in the knee joints of rats subjected to knee meniscectomy...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685834/effect-of-increased-coronal-inclination-of-the-tibial-plateau-after-opening-wedge-high-tibial-osteotomy
#12
Yasushi Akamatsu, Ken Kumagai, Hideo Kobayashi, Masaki Tsuji, Tomoyuki Saito
PURPOSE: To assess whether the increased inclination of the tibial plateau on the coronal view after opening-wedge high tibial osteotomy affects radiographic coronal alignment, clinical outcomes, and cartilage findings. METHODS: After adjustment for the preoperative medial proximal tibial angle (MPTA), patients who underwent opening-wedge high tibial osteotomy were retrospectively divided into those with postoperative MPTA values of 95° or less (normal group) and greater than 95° (increased group), with each group containing 43 knees...
April 20, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29685524/medial-meniscal-extrusion-detection-evaluation-and-clinical-implications
#13
REVIEW
Nayanatara Swamy, Vibhor Wadhwa, Gitanjali Bajaj, Avneesh Chhabra, Tarun Pandey
The menisci play an important role in knee kinematics. Their unique anatomy allows them to channel forces generated during knee movements through the larger tibio-femoral condylar surfaces while simultaneously resisting deleterious hoop stresses. Although physiologic meniscal extrusion occurs with every knee joint movement, pathologic meniscal extrusion subjects the knee to persistent and excessive load transmission. This renders the knee structures susceptible to injury or exacerbates worsening of existing knee joint internal derangement...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29678623/differences-in-subchondral-bone-plate-and-cartilage-thickness-between-women-with-anterior-cruciate-ligament-reconstructions-and-uninjured-controls
#14
Jennifer L Bhatla, Andres Kroker, Sarah L Manske, Carolyn A Emery, Steven K Boyd
OBJECTIVE: Anterior cruciate ligament (ACL) tears increase early onset osteoarthritis (OA) risk leading to cartilage and bone degradation. While the contribution of bone in OA development is unclear, evidence suggests that bone changes accompany cartilage degradation. This study aims to assess if regions with differences in subchondral bone plate thickness have differences in cartilage thickness when comparing ACL reconstructed (ACLR) knees of women ≥5 years post-injury to contralateral and controls with uninjured knees...
April 17, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29673544/no-effect-of-creatine-monohydrate-supplementation-on-inflammatory-and-cartilage-degradation-biomarkers-in-individuals-with-knee-osteoarthritis
#15
Stephen M Cornish, Jason D Peeler
The study purpose was to evaluate the effectiveness of creatine monohydrate supplementation (20 grams/day for 1 week and then 5 grams/day for 11 weeks) on inflammation (C-reactive protein, interleukin-1β, interleukin-6, s100 A8/A9, and tumor necrosis factor-α) and cartilage degradation (serum cartilage oligomeric matrix protein) in patients with knee osteoarthritis. We hypothesized that supplementing with creatine monohydrate for 12 weeks would lower biomarkers of inflammation and cartilage degradation in patients with knee osteoarthritis when compared to placebo...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29672434/assessment-of-cartilage-growth-after-biopsy-of-osteochondral-loose-bodies-in-adolescent-knees-for-use-in-autologous-chondrocyte-implantation
#16
Sean Robinson, Jonathan Kramer, Trevor Shelton, Jarrad Merriman, Brian Haus
BACKGROUND: The goal of this study is to determine whether harvested cartilage from an osteochondral loose body maintains the same viability for implantation as cartilage harvested from the traditional locations within the adolescent knee for autologous chondrocyte implantation (ACI). METHODS: A retrospective study was performed on all ACI procedures performed from 2014 to 2017 at a single institution. Biopsies were derived from 2 groups: osteochondral loose body verses the intercondylar notch...
April 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29667733/longitudinal-analysis-of-tibiofemoral-cartilage-contact-area-and-position-in-acl-reconstructed-patients
#17
Ellison Chen, Keiko Amano, Valentina Pedoia, Richard B Souza, C Benjamin Ma, Xiaojuan Li
Patients who have suffered ACL injury are more likely to develop early onset post-traumatic osteoarthritis despite reconstruction. The purpose of our study was to evaluate the longitudinal changes in the tibiofemoral cartilage contact area size and location after ACL injury and reconstruction. Thirty-one patients with isolated unilateral ACL injury were followed with T2 weighted Fast Spin Echo, T1ρ and T2 MRI at baseline prior to reconstruction, and 6 months, 1 year, and 2 years after surgery. Areas were delineated in FSE images with an in-house Matlab program using a spline-based semi-automated segmentation algorithm...
April 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29665801/an-extended-opensim-knee-model-for-analysis-of-strains-of-connective-tissues
#18
M Marieswaran, Arnab Sikidar, Anu Goel, Deepak Joshi, Dinesh Kalyanasundaram
BACKGROUND: OpenSim musculoskeletal models provide an accurate simulation environment that eases limitations of in vivo and in vitro studies. In this work, a biomechanical knee model was formulated with femoral articular cartilages and menisci along with 25 connective tissue bundles representing ligaments and capsules. The strain patterns of the connective tissues in the presence of femoral articular cartilage and menisci in the OpenSim knee model was probed in a first of its kind study...
April 17, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29665604/-foreign-material-free-anterior-cruciate-ligament-repair-with-hamstring-graft-felmet-technique
#19
Marc Chmielnicki, Wolfram Siebert, Axel Prokop
Rupture of the anterior cruciate ligament (ACL) is a common sports injury. Shear forces can damage the articular cartilage and lead to early osteoarthritis. Ligamentary stabilisation of the knee is necessary. Today, arthroscopic ACL repair is a standard knee procedure. Transplant fixation is often performed using implants, e.g. interference screws. The foreign material-free procedure using the Felmet technique enables biological, mechanically stable fixation of the hamstring tendon graft. We demonstrate the surgical technique, including meniscus suture and a video case study...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29662913/high-rate-of-missed-lateral-meniscus-posterior-root-tears-on-preoperative-magnetic-resonance-imaging
#20
Aaron J Krych, Isabella T Wu, Vishal S Desai, Naveen S Murthy, Mark S Collins, Daniel B F Saris, Bruce A Levy, Michael J Stuart
Background: Lateral meniscus posterior root tears (LMPRTs), if left untreated, can cause devastating effects to the knee, with rapid articular cartilage degeneration and loss of the meniscus as a secondary stabilizer. Detection and surgical repair of these defects have been linked to favorable outcomes, but preoperative identification of LMPRTs continues to be challenging. Purpose: To determine the rate of LMPRTs diagnosed preoperatively on magnetic resonance imaging (MRI) in a consecutive series of arthroscopically confirmed LMPRTs...
April 2018: Orthopaedic Journal of Sports Medicine
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