Vincenzo Oliva, Chiara Possidente, Michele De Prisco, Giovanna Fico, Gerard Anmella, Diego Hidalgo-Mazzei, Andrea Murru, Giuseppe Fanelli, Chiara Fabbri, Michele Fornaro, Andrea de Bartolomeis, Marco Solmi, Joaquim Radua, Eduard Vieta, Alessandro Serretti
BACKGROUND: There are no recommendations based on the efficacy of specific drugs for the treatment of psychotic depression. To address this evidence gap, we did a network meta-analysis to assess and compare the efficacy and safety of pharmacological treatments for psychotic depression. METHODS: In this systematic review and network meta-analysis, we searched ClinicalTrials.gov, CENTRAL, Embase, PsycINFO, PubMed, Scopus, and Web of Science from inception to Nov 23, 2023 for randomised controlled trials published in any language that assessed pharmacological treatments for individuals of any age with a diagnosis of a major depressive episode with psychotic features, in the context of major depressive disorder or bipolar disorder in any setting...
March 2024: Lancet Psychiatry