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Tetrahydrocurcumin

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https://www.readbyqxmd.com/read/27748926/suppression-of-grasp65-phosphorylation-by-tetrahydrocurcumin-protects-against-cerebral-ischemia-reperfusion-injury-via-erk-signaling
#1
Bin Lin, Heng Yu, Yuting Lin, Chao Cai, Huoquan Lu, Xinbo Zhu
The aim of the present study was to assess the neuroprotective effects of tetrahydrocurcumin (THC) in a mouse model of cerebral ischemia/reperfusion (I/R) injury, and to investigate the involvement of Golgi reassembly and stacking protein 65 (GRASP65) and the extracellular signal‑regulated kinase (ERK) signaling pathway. Cerebral I/R injury was induced using the Pulsinelli four‑vessel occlusion method. After 5 min of reperfusion, mice received THC (5, 10 or 25 mg/kg) or saline by intraperitoneal injection...
October 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27713040/tetrahydrocurcumin-in-combination-with-deferiprone-attenuates-hypertension-vascular-dysfunction-baroreflex-dysfunction-and-oxidative-stress-in-iron-overloaded-mice
#2
Weerapon Sangartit, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Wanida Donpunha, Shigeki Shibahara, Upa Kukongviriyapan
Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice developed increased blood pressure, impaired vascular function and blunted response of the autonomic nervous system. These effects were accompanied by increased malondialdehyde levels in various tissues, increased nitric oxide metabolites in plasma and urine, and decreased blood glutathione...
October 3, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#3
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
September 23, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27327398/use-of-basic-mobile-phase-to-improve-chromatography-and-boost-sensitivity-for-quantifying-tetrahydrocurcumin-in-human-plasma-by-lc-ms-ms
#4
Aimin Tan, Yanxin Wu, Molly Wong, Albert Licollari, Gordon Bolger, John C Fanaras, George Shopp, Lawrence Helson
Tetrahydrocurcumin (THC), a major metabolite of curcumin, is often quantified by LC-MS or LC-MS/MS using acidic mobile phases due to the concern of its instability in a basic medium. However, acidic mobile phases often lead to poor chromatography (e.g. split or double peaks) and reduced detection sensitivity in the commonly used negative ionization mode. To overcome these shortcomings, a basic mobile phase was used for the first time in the LC-MS/MS quantification of THC. In comparison with the acidic mobile phases, a single symmetrical chromatographic peak was obtained and the sensitivity increased by 7-fold or more under the equivalent conditions...
August 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27151191/oxidative-stress-and-cardiovascular-dysfunction-associated-with-cadmium-exposure-beneficial-effects-of-curcumin-and-tetrahydrocurcumin
#5
Upa Kukongviriyapan, Kwanjit Apaijit, Veerapol Kukongviriyapan
Cadmium (Cd) is a non-essential heavy metal with high toxicity potential. Humans are exposed to Cd present in diet, polluted air, and cigarette smoke. Cd exposure has been associated with increased risk of chronic diseases, including hypertension, atherosclerosis, diabetes, and nephropathy, all of which could be attributable to dysfunctional endothelial and smooth muscle cells. Cd toxicity is correlated with increased reactive oxygen formation and depletion of antioxidants, resulting in an oxidative stress...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/26899573/inhibitory-effects-and-molecular-mechanisms-of-tetrahydrocurcumin-against-human-breast-cancer-mcf-7-cells
#6
Xiao Han, Shan Deng, Ning Wang, Yafei Liu, Xingbin Yang
BACKGROUND: Tetrahydrocurcumin (THC), an active metabolite of curcumin, has been reported to have similar biological effects to curcumin, but the mechanism of the antitumor activity of THC is still unclear. METHODS: The present study was to investigate the antitumor effects and mechanism of THC in human breast cancer MCF-7 cells using the methods of MTT assay, LDH assay, flow cytometry analysis, and western blot assay. RESULTS: THC was found to have markedly cytotoxic effect and antiproliferative activity against MCF-7 cells in a dose-dependent manner with the IC50 for 24 h of 107...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/26881213/effects-of-tetrahydrocurcumin-on-tumor-growth-and-cellular-signaling-in-cervical-cancer-xenografts-in-nude-mice
#7
Bhornprom Yoysungnoen, Parvapan Bhattarakosol, Chatchawan Changtam, Suthiluk Patumraj
Tetrahydrocurcumin (THC) is a stable metabolite of curcumin (CUR) in physiological systems. The mechanism underlying the anticancer effect of THC is not completely understood. In the present study, we investigated the effects of THC on tumor growth and cellular signaling in cervical cancer xenografts in nude mice. Cervical cancer cells (CaSki) were subcutaneously injected in nude mice to establish tumors. One month after the injection, mice were orally administered vehicle or 100, 300, and 500 mg/kg of THC daily for 30 consecutive days...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26798036/structural-interactions-of-curcumin-biotransformed-molecules-with-the-n-terminal-residues-of-cytotoxic-associated-gene-a-protein-provide-insights-into-suppression-of-oncogenic-activities
#8
Akhileshwar Kumar Srivastava, Divya Singh, Bijoy Krishna Roy
Curcumin as a natural product has drawn considerable attention in recent years for its multiple pharmacological activities against various diseases, but more studies are required to understand the curcumin pharmacological action considering its low bioavailability. Though numerous reasons contribute to the low bioavailability of curcumin, one of the important reasons is associated with biotransformation of curcumin through either conjugation or reduction depending on curcumin administration route. The orally administered curcumin (CUR) is metabolised into curcumin glucuronidase (CUR-GLR) and curcumin sulphate by conjugation, whereas dihydroxycurcumin, tetrahydrocurcumin, and hexahydrocurcumin (HHC) are formed by reduction after intraperitoneal administration of curcumin...
January 21, 2016: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/26471074/the-degradation-of-curcuminoids-in-a-human-faecal-fermentation-model
#9
Suryani Tan, Luca Calani, Letizia Bresciani, Margherita Dall'asta, Andrea Faccini, Mary Ann Augustin, Sally L Gras, Daniele Del Rio
In the present study, the colonic metabolism of three curcuminoids (80.1% curcumin, 15.6%, demethoxycurcumin (DMC) and 2.6% bis-demethoxycurcumin (Bis-DMC)) was evaluated using an in vitro model containing human faecal starters. The breakdown products formed were identified and characterized using different analytical platforms. Following in vitro incubation, the relative amounts of degraded curcuminoids and the produced metabolites were analyzed using a UHPLC coupled with a linear ion trap mass spectrometer, with the addition of hybrid ion trap-Orbitrap Mass Spectrometer when required...
2015: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/26404226/ms-based-metabolite-profiling-of-aboveground-and-root-components-of-zingiber-mioga-and-officinale
#10
Ji Soo Han, Sunmin Lee, Hyang Yeon Kim, Choong Hwan Lee
Zingiber species are members of the Zingiberaceae family, and are widely used for medicinal and food purposes. In this study aboveground and root parts of Zingiber mioga and Zingiber officinale were subjected to metabolite profiling by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) in order to characterize them by species and parts and also to measure bioactivities. Both primary and secondary metabolites showed clear discrimination in the PCA score plot and PLS-DA by species and parts...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26203224/wound-healing-a-new-perspective-on-glucosylated-tetrahydrocurcumin
#11
Adari Bhaskar Rao, Ernala Prasad, Seelam Siva Deepthi, Vennapusa Haritha, Sistla Ramakrishna, Kuncha Madhusudan, Mullapudi Venkata Surekha, Yerramilli Sri Rama Venkata Rao
Wound healing represents a dynamic set of coordinated physiological processes observed in response to tissue injury. Several natural products are known to accelerate the process of wound healing. Tetrahydrocurcumin (THC), an in vivo biotransformed product/metabolite of curcumin, is known to exhibit a wide spectrum of biological activities similar to those of native curcuminoids. The poor bioavailability of these curcuminoids limits their clinical applications. The present study highlights the percutaneous absorption and wound healing activity of glucosyl-conjugated THC (glucosyl-THC) in male Wistar rats...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26102012/tetrahydrocurcumin-exerts-protective-effect-on-vincristine-induced-neuropathy-behavioral-biochemical-neurophysiological-and-histological-evidence
#12
N Greeshma, K G Prasanth, Bhaskar Balaji
Hyperalgesia, allodynia, delayed motor nerve conduction velocity, oxidative stress and axonal damage are signs and symptoms of chemotherapy induced peripheral neuropathy (CIPN). Present treatment/preventive strategies of CIPN are futile and the neuropathy may even lead to discontinuation of chemotherapy. In this study, we evaluated the protective effect of tetrahydrocurcumin (THC) 40 and 80mg/kg in experimental vincristine induced neuropathy in rats. Hyperalgesia was assessed by hot plate (thermal), Randall-Selitto (mechanical) test, allodynia was assessed by cold plate (thermal) test, functional loss was measured by sciatic function index, nociception was evaluated by formalin test...
August 5, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26102010/effect-of-tetrahydrocurcumin-on-the-profiles-of-drug-metabolizing-enzymes-induced-by-a-high-fat-and-high-fructose-diet-in-mice
#13
Nattharat Jearapong, Waranya Chatuphonprasert, Kanokwan Jarukamjorn
Cytochrome P450 (CYP), a superfamily of hepatic monooxygenase enzymes, catalyzes biotransformation of endogenous compounds and xenobiotics. Modification of CYPs associated with metabolic diseases and continuous consumption of diet with excessive energy levels. Tetrahydrocurcumin (THC) exhibited beneficial effects in metabolic syndromes such as diabetic mellitus and dyslipidemia. The present study aimed to investigate the effects of THC and vitamin E (vitE) on the expression profiles of CYPs in the livers of mice fed with the high fat and high fructose diet...
September 5, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/25869292/ameliorative-efficacy-of-tetrahydrocurcumin-against-arsenic-induced-oxidative-damage-dyslipidemia-and-hepatic-mitochondrial-toxicity-in-rats
#14
M Muthumani, S Miltonprabu
Arsenic (As) is a well-known human carcinogen and a potent hepatotoxin. Environmental exposure to arsenic imposes a serious health hazard to humans and other animals worldwide. Tetrahydrocurcumin (THC), one of the major metabolites of curcumin, exhibits many of the same physiological and pharmacological activities as curcumin and in some systems may exert greater antioxidant activity than the curcumin. It has been reported that THC has antioxidant efficacy attributable to the presence of identical β-diketone of 3rd and 5th substitution in heptane moiety...
June 25, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/25789317/effects-of-tetrahydrocurcumin-on-hypoxia-inducible-factor-1%C3%AE-and-vascular-endothelial-growth-factor-expression-in-cervical-cancer-cell-induced-angiogenesis-in-nude-mice
#15
Bhornprom Yoysungnoen, Parvapan Bhattarakosol, Suthiluk Patumraj, Chatchawan Changtam
Tetrahydrocurcumin (THC), one of the important in vivo metabolites of curcumin, inhibits tumor angiogenesis. Its effects on angiogenesis in cervical cancer- (CaSki-) implanted nude mice and its mechanisms on hypoxia-inducible factor-1α and vascular endothelial growth factor expression were investigated. Female BALB/c nude mice were divided into control (CON) and CaSki-implanted groups (CaSki group). One month after the injection with cervical cancer cells, mice were orally administered vehicle or 100, 300, and 500 mg/kg of THC daily for 30 consecutive days...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25742657/correction-tetrahydrocurcumin-protects-against-cadmium-induced-hypertension-raised-arterial-stiffness-and-vascular-remodeling-in-mice
#16
(no author information available yet)
No abstract text is available yet for this article.
2015: PloS One
https://www.readbyqxmd.com/read/25719941/protective-effect-of-tetrahydrocurcumin-against-cisplatin-induced-renal-damage-in-vitro-and-in-vivo-studies
#17
Kyung Il Song, Jun Yeon Park, Seungyong Lee, Dahae Lee, Hyuk-Jai Jang, Su-Nam Kim, Hyeonseok Ko, Hyun Young Kim, Jae Wook Lee, Gwi Seo Hwang, Ki Sung Kang, Noriko Yamabe
The adverse effects of anticancer drugs can prompt patients to end their treatment despite the efficacy. Cisplatin is a platinum-based molecule widely used to treat various forms of cancer, but frequent and long-term use of cisplatin is limited due to severe nephrotoxicity. In the present study, we investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage, oxidative stress, and inflammation to evaluate its possible use in renal damage. Cisplatin-induced LLC-PK1 renal cell damage was significantly reduced by tetrahydrocurcumin treatment...
March 2015: Planta Medica
https://www.readbyqxmd.com/read/25502771/tetrahydrocurcumin-protects-against-cadmium-induced-hypertension-raised-arterial-stiffness-and-vascular-remodeling-in-mice
#18
Weerapon Sangartit, Upa Kukongviriyapan, Wanida Donpunha, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Praphassorn Surawattanawan, Stephen E Greenwald
BACKGROUND: Cadmium (Cd) is a nonessential heavy metal, causing oxidative damage to various tissues and associated with hypertension. Tetrahydrocurcumin (THU), a major metabolite of curcumin, has been demonstrated to be an antioxidant, anti-diabetic, anti-hypertensive and anti-inflammatory agent. In this study, we investigated the protective effect of THU against Cd-induced hypertension, raised arterial stiffness and vascular remodeling in mice. METHODS: Male ICR mice received CdCl2 (100 mg/l) via drinking water for 8 weeks...
2014: PloS One
https://www.readbyqxmd.com/read/25502175/curcumin-and-its-major-metabolites-inhibit-the-inflammatory-response-induced-by-lipopolysaccharide-translocation-of-nuclear-factor-%C3%AE%C2%BAb-as-potential-target
#19
Feng Zhao, Yudian Gong, Yuan Hu, Minghui Lu, Jing Wang, Jianxin Dong, Daquan Chen, Lei Chen, Fenghua Fu, Feng Qiu
The aim of the present study was to investigate and compare the anti‑inflammatory activities of curcumin and its three metabolites, tetrahydrocurcumin, hexahydrocurcumin and octahydrocurcumin in lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophage cells. The results demonstrated that overproduction of nitric oxide (NO) was potently inhibited following treatment with curcumin and its three metabolites. In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor‑α (TNF‑α) and interleukin‑6 (IL‑6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release...
April 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25500488/safety-tolerability-and-pharmacokinetics-of-liposomal-curcumin-in-healthy-humans
#20
RANDOMIZED CONTROLLED TRIAL
Angela Storka, Brigitta Vcelar, Uros Klickovic, Ghazaleh Gouya, Stefan Weisshaar, Stefan Aschauer, Gordon Bolger, Lawrence Helson, Michael Wolzt
INTRODUCTION: Experimental studies have shown that liposomal curcumin can exert a reduction in tumor growth in pancreatic and colorectal cancer. In this phase I clinical trial we investigated the pharmacokinetics, safety, and tolerability of intravenously administered liposomal curcumin in healthy subjects. MATERIAL AND METHODS: 50 male and female participants were included in this randomized, placebo-controlled double-blind phase I dose escalation study. Subjects received a single dose of liposomal curcumin (10 - 400 mg/m2; n = 2 - 6 per group) or placebo over 2 hours intravenously...
January 2015: International Journal of Clinical Pharmacology and Therapeutics
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