keyword
MENU ▼
Read by QxMD icon Read
search

TLE and Cognition

keyword
https://www.readbyqxmd.com/read/28207604/memory-rehabilitation-strategies-in-nonsurgical-temporal-lobe-epilepsy-a-review
#1
Alessandra Del Felice, Marzia Alderighi, Matteo Martinato, Davide Grisafi, Anna Bosco, Pamela J Thompson, Josemir W Sander, Stefano Masiero
People with temporal lobe epilepsy (TLE) who have not undergone epilepsy surgery often complain of memory deficits. Cognitive rehabilitation is employed as a remedial intervention in clinical settings, but research is limited and findings concerning efficacy and the criteria for choosing different approaches have been inconsistent. We aimed to appraise existing evidence on memory rehabilitation in nonsurgical individuals with temporal lobe epilepsy and to ascertain the effectiveness of specific strategies. A scoping review was preferred given the heterogeneous nature of the interventions...
February 15, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28195438/from-rest-to-language-task-task-activation-selects-and-prunes-from-broader-resting-state-network
#2
Gaelle E Doucet, Xiaosong He, Michael R Sperling, Ashwini Sharan, Joseph I Tracy
Resting-state networks (RSNs) show spatial patterns generally consistent with networks revealed during cognitive tasks. However, the exact degree of overlap between these networks has not been clearly quantified. Such an investigation shows promise for decoding altered functional connectivity (FC) related to abnormal language functioning in clinical populations such as temporal lobe epilepsy (TLE). In this context, we investigated the network configurations during a language task and during resting state using FC...
February 14, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28138428/automated-tractography-in-patients-with-temporal-lobe-epilepsy-using-tracts-constrained-by-underlying-anatomy-tracula
#3
Barbara A K Kreilkamp, Bernd Weber, Mark P Richardson, Simon S Keller
PURPOSE: A detailed understanding of white matter tract alterations in patients with temporal lobe epilepsy (TLE) is important as it may provide useful information for likely side of seizure onset, cognitive impairment and postoperative prognosis. However, most diffusion-tensor imaging (DTI) studies have relied on manual reconstruction of tract bundles, despite the recent development of automated techniques. In the present study, we used an automated white matter tractography analysis approach to quantify temporal lobe white matter tract alterations in TLE and determine the relationships between tract alterations, the extent of hippocampal atrophy and the chronicity and severity of the disorder...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28131931/reading-in-children-with-temporal-lobe-epilepsy-a-systematic-review
#4
REVIEW
Suncica Lah, Anne Castles, Mary Lou Smith
OBJECTIVE: Children with epilepsy have higher rates of reading difficulties compared to the general population. Reading difficulties are associated with lower academic attainments, higher school drop-out rates, greater risk of unemployment, lower income, and poorer adjustment. We examined the literature dealing with reading in children with the most common type of focal epilepsy, temporal lobe epilepsy (TLE), in relation to: presence of reading difficulties, contributing factors, and efficacy of treatments for reading difficulties...
January 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109987/mismatch-negativity-is-abnormal-but-not-lateralizing-in-temporal-lobe-epilepsy
#5
Lili Zhao, Dongmei An, Limei Mao, Xiangdong Tang, Li He, Dong Zhou
We investigated the changes of mismatch negativity (MMN) in patients with temporal lobe epilepsy (TLE) and explored the possible role of MMN in lateralizing their seizure focus. Thirty patients with TLE and thirty healthy controls were included. MMN was elicited in each subject. Patients with TLE were divided into three subgroups: unilateral left TLE; unilateral right TLE, and bilateral TLE. MMN amplitudes and latencies were compared between the patients with TLE and the control group, and also among the three subgroups of TLE, using repeated measures analyses of variance (ANOVA)...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28104461/cxcr4-antagonist-amd3100-reverses-the-neurogenesis-promoted-by-enriched-environment-and-suppresses-long-term-seizure-activity-in-adult-rats-of-temporal-lobe-epilepsy
#6
Zhike Zhou, Tingting Liu, Xiaoyu Sun, Xiaopeng Mu, Gang Zhu, Ting Xiao, Mei Zhao, Chuansheng Zhao
It has been showed that enriched environment (EE) enhances the hippocampal neurogenesis and improves the cognitive impairments, accompanied by the increased expressions of stromal cell-derived factor-1 (SDF-1) in adult rats of temporal lobe epilepsy (TLE). We examined whether the enhanced neurogenesis and improved cognitive functions induced by EE following seizures were mediated by SDF-1/CXCR4 pathway. Therefore, we investigated the effects of the EE combined with CXCR4 antagonist AMD3100 on neurogenesis, cognitive functions and the long-term seizure activity in the TLE model...
January 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28089585/the-impact-of-intelligence-on-memory-and-executive-functions-of-children-with-temporal-lobe-epilepsy-methodological-concerns-with-clinical-relevance
#7
Patricia Rzezak, Catarina A Guimarães, Marilisa M Guerreiro, Kette D Valente
PURPOSE: Patients with TLE are prone to have lower IQ scores than healthy controls. Nevertheless, the impact of IQ differences is not usually considered in studies that compared the cognitive functioning of children with and without epilepsy. This study aimed to determine the effect of using IQ as a covariate on memory and attentional/executive functions of children with TLE. METHODS: Thirty-eight children and adolescents with TLE and 28 healthy controls paired as to age, gender, and sociodemographic factors were evaluated with a comprehensive neuropsychological battery for memory and executive functions...
December 29, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27942449/resting-state-functional-network-disruptions-in-a-kainic-acid-model-of-temporal-lobe-epilepsy
#8
Ravnoor Singh Gill, Seyed M Mirsattari, L Stan Leung
We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed as networks in epileptic and control rats. Graph theoretical analysis revealed a significant increase in functional connectivity between brain areas in epileptic than control rats, and the connected brain areas could be categorized as a limbic network and a default mode network (DMN)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27924527/cognitive-functioning-in-temporal-lobe-epilepsy-a-bold-fmri-study
#9
Lili Guo, Genji Bai, Hui Zhang, Daoyan Lu, Jiyong Zheng, Gang Xu
We aimed to analyze the association between resting-state functional magnetic resonance imaging (re-fMRI) and cognitive function (including language, executive, and memory functions) in temporal lobe epilepsy (TLE) patients, which will help to explore the mechanism of brain function in patients. 15 TLE patients and 15 non-TLE patients were recruited. All subjects underwent neuropsychological testing and memory functional evaluation. Changes in verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), full intelligence quotient (FIQ), and memory quotient (MQ) were compared between two groups...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27743551/early-childhood-trauma-and-hippocampal-volumes-in-patients-with-epileptic-and-psychogenic-seizures
#10
Benjamin Johnstone, Dennis Velakoulis, Cheng Yi Yuan, Anthony Ang, Chris Steward, Patricia Desmond, Terence J O'Brien
OBJECTIVE: Exposure to early life childhood trauma has been implicated as resulting in a vulnerability to epileptic and psychogenic nonepileptic seizures (PNES), hippocampal atrophy, and psychiatric disorders. This study aimed to explore the relationships between childhood trauma, epilepsy, PNES, and hippocampal volume in patients admitted to a video-electroencephalogram monitoring (VEM) unit. METHODS: One hundred thirty-one patients were recruited from the Royal Melbourne Hospital VEM unit...
November 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27736661/postictal-alterations-induced-by-intrahippocampal-injection-of-pilocarpine-in-c57bl-6-mice
#11
Isabel Vieira de Assis Lima, Alline Cristina de Campos, Paula Maria Quaglio Bellozi, Juliana Guimaraes Doria, Fabiola Mara Ribeiro, Marcio Flavio Dutra Moraes, Antonio Carlos Pinheiro de Oliveira
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults. The pilocarpine (PILO) experimental model of TLE portrays behavioral and pathophysiological changes in rodents that are very similar to those found in humans with TLE. However, this model is associated with an unfortunate high mortality rate. Studies have shown that intrahippocampal injection of PILO, while having a much smaller mortality rate, induces status epilepticus (SE) that secondarily leads to TLE. To the best of our knowledge, the present study was the first to evaluate the cognitive and histological alterations 72h after intrahippocampal microinjection of PILO in C57BL/6 mice...
October 10, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27731507/remembrance-and-time-passed-memory-outcomes-4-11-years-after-pediatric-epilepsy-surgery
#12
Klajdi Puka, Mary Lou Smith
OBJECTIVE: Little is known about the long-term cognitive outcomes following pediatric epilepsy surgery. Although the evidence for change within the first 2 years is not compelling, the plasticity of the immature brain may allow for improvements in the long term. This study examined memory function in a cohort of surgical and nonsurgical patients at baseline and 4-11 years after. METHOD: Participants were 88 patients (mean age 20.05, standard deviation [SD] 4.21 years) with childhood-onset intractable epilepsy; 53 had undergone resective epilepsy surgery...
November 2016: Epilepsia
https://www.readbyqxmd.com/read/27707196/depressive-symptoms-contribute-to-executive-deficits-in-temporal-lobe-epilepsy
#13
Rachel Galioto, Geoffrey Tremont, Andrew S Blum, W Curt LaFrance, Cara L Crook, Jennifer D Davis
This study examined the contribution of depression to reduced executive functioning in temporal lobe epilepsy (TLE) using three groups: TLE only (TLE; N=29), TLE+depression (TLE+DEP) (N=22), and nonneurologic participants with depression (DEP; N=31). Participants completed the Delis-Kaplan Executive Function System. Individuals with TLE performed worse than the DEP group on many tests of executive functions. Among the TLE participants, those with depression demonstrated poorer executive functioning. These findings support the notion that depression may further contribute to executive difficulties in individuals with TLE...
October 6, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27628031/the-temporal-instability-of-resting-state-network-connectivity-in-intractable-epilepsy
#14
Lucy F Robinson, Xiaosong He, Paul Barnett, Gaёlle E Doucet, Michael R Sperling, Ashwini Sharan, Joseph I Tracy
OBJECTIVE: Focal epilepsies, such as temporal lobe epilepsy (TLE), are known to disrupt network activity in areas outside the epileptogenic zone [Tracy et al., 2015]. We devised a measure of temporal instability of resting state functional connectivity (FC), capturing temporal variations of BOLD correlations between brain regions that is less confounded than the "sliding window" approach common in the literature. METHODS: We investigated healthy controls and unilateral TLE patients (right and left seizure focus groups), utilizing group ICA to identify the default mode network (DMN), a network associated with episodic memory, a key cognitive deficit in TLE...
January 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/27532817/neural-stem-cell-or-human-induced-pluripotent-stem-cell-derived-gaba-ergic-progenitor-cell-grafting-in-an-animal-model-of-chronic-temporal-lobe-epilepsy
#15
Dinesh Upadhya, Bharathi Hattiangady, Geetha A Shetty, Gabriele Zanirati, Maheedhar Kodali, Ashok K Shetty
Grafting of neural stem cells (NSCs) or GABA-ergic progenitor cells (GPCs) into the hippocampus could offer an alternative therapy to hippocampal resection in patients with drug-resistant chronic epilepsy, which afflicts >30% of temporal lobe epilepsy (TLE) cases. Multipotent, self-renewing NSCs could be expanded from multiple regions of the developing and adult brain, human embryonic stem cells (hESCs), and human induced pluripotent stem cells (hiPSCs). On the other hand, GPCs could be generated from the medial and lateral ganglionic eminences of the embryonic brain and from hESCs and hiPSCs...
August 17, 2016: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/27532489/mapping-the-neuropsychological-profile-of-temporal-lobe-epilepsy-using-cognitive-network-topology-and-graph-theory
#16
Tanja S Kellermann, Leonardo Bonilha, Ramin Eskandari, Camille Garcia-Ramos, Jack J Lin, Bruce P Hermann
OBJECTIVE: Normal cognitive function is defined by harmonious interaction among multiple neuropsychological domains. Epilepsy has a disruptive effect on cognition, but how diverse cognitive abilities differentially interact with one another compared with healthy controls (HC) is unclear. This study used graph theory to analyze the community structure of cognitive networks in adults with temporal lobe epilepsy (TLE) compared with that in HC. METHODS: Neuropsychological assessment was performed in 100 patients with TLE and 82 HC...
October 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27494355/interictal-epileptic-discharge-correlates-with-global-and-frontal-cognitive-dysfunction-in-temporal-lobe-epilepsy
#17
Vera Dinkelacker, Xu Xin, Michel Baulac, Séverine Samson, Sophie Dupont
OBJECTIVE: Temporal lobe epilepsy (TLE) with hippocampal sclerosis has widespread effects on structural and functional connectivity and often entails cognitive dysfunction. EEG is mandatory to disentangle interactions in epileptic and physiological networks which underlie these cognitive comorbidities. Here, we examined how interictal epileptic discharges (IEDs) affect cognitive performance. METHODS: Thirty-four patients (right TLE=17, left TLE=17) were examined with 24-hour video-EEG and a battery of neuropsychological tests to measure intelligence quotient and separate frontal and temporal lobe functions...
September 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27458343/dystrophin-distribution-and-expression-in-human-and-experimental-temporal-lobe-epilepsy
#18
Ruben G F Hendriksen, Sandra Schipper, Govert Hoogland, Olaf E M G Schijns, Jim T A Dings, Marlien W Aalbers, Johan S H Vles
OBJECTIVE: Dystrophin is part of a protein complex that connects the cytoskeleton to the extracellular matrix. In addition to its role in muscle tissue, it functions as an anchoring protein within the central nervous system such as in hippocampus and cerebellum. Its presence in the latter regions is illustrated by the cognitive problems seen in Duchenne Muscular Dystrophy (DMD). Since epilepsy is also supposed to constitute a comorbidity of DMD, it is hypothesized that dystrophin plays a role in neuronal excitability...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27452151/altered-anterior-posterior-connectivity-through-the-arcuate-fasciculus-in-temporal-lobe-epilepsy
#19
Shigetoshi Takaya, Hesheng Liu, Douglas N Greve, Naoaki Tanaka, Catherine Leveroni, Andrew J Cole, Steven M Stufflebeam
How the interactions between cortices through a specific white matter pathway change during cognitive processing in patients with epilepsy remains unclear. Here, we used surface-based structural connectivity analysis to examine the change in structural connectivity with Broca's area/the right Broca's homologue in the lateral temporal and inferior parietal cortices through the arcuate fasciculus (AF) in 17 patients with left temporal lobe epilepsy (TLE) compared with 17 healthy controls. Then, we investigated its functional relevance to the changes in task-related responses and task-modulated functional connectivity with Broca's area/the right Broca's homologue during a semantic classification task of a single word...
December 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27444122/microrna-328a-regulates-water-maze-performance-in-ptz-kindled-rats
#20
Yuhan Liao, Yiqing Huang, Xixia Liu, Chun Luo, Donghua Zou, Xing Wei, Qi Huang, Yuan Wu
The down-regulation of microRNA-328a (miR-328a) in pentylenetetrazole (PTZ)-kindled rats with memory impairment was demonstrated in our previous study, while any contribution of miR-328a to cognitive dysfunction of PTZ-kindled rats remains unknown. In this study we have investigated the effect and the underlying mechanism of miR-328a on the cognitive function in PTZ-kindled rats. 48 SD male rats were divided into 4 groups as follows: a PTZ kindled group, a miR-328a antagomir group, an antagomir-control group, and a sham group (n=12 for each)...
July 2016: Brain Research Bulletin
keyword
keyword
4146
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"