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hepatic cirrosis

Fabiano Di Marco, Giuseppina Palumbo, Silvia Terraneo, Gianluca Imeri, Elena Lesma, Nicola Sverzellati, Angela Peron, Lorenzo Gualandri, Maria Paola Canevini, Stefano Centanni
BACKGROUND: Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our knowledge, the first description of a patient with the coexistence of these three diseases. CASE PRESENTATION: A 47-year-old woman affected by LAM-TSC and primary biliary cirrosis/autoimmune hepatitis overlap syndrome. During her follow up a high resolution chest CT scan (HRTC) confirmed the presence of both multiple cysts and micronodular opacities consistent with multifocal micronodular pneumocytes hyperlasia (MMPH), and revealed multiple hilar-mediastinal symmetrical lymphadenopathies suggestive of sarcoidosis...
July 28, 2017: BMC Pulmonary Medicine
Su Jeong Lee, Hanvit Cha, Hyunjin Kim, Jin Hyup Lee, Jeen-Woo Park
Nonalcoholic fatty liver disease (NAFLD) has a high prevalence in the general population and can evolve into nonalcoholic steatohepatosis (NASH), cirrhosis, and complications such as liver failure and hepatocellular carcinoma. Recently, we reported that mitochondrial NADP(+)-dependent isocitrate dehydrogenase, encoded by the IDH2, plays an important role in the regulation of redox balance and oxidative stress levels, which are tightly associated with intermediary metabolism and energy production. In the present study, we showed that in mice targeted disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38/cJun NH2-terminal kinase (JNK) and p53, presumably induced by the elevation of mitochondrial reactive oxygen species (ROS), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21) and the inhibition of NFκB signaling pathways...
May 5, 2017: Free Radical Research
Raúl Carrillo-Esper, Ulises Carrillo-Cortes, Jorge Raúl Carrillo-Córdova, Luis Daniel Carrillo-Córdova, Carlos Alberto Carrillo-Córdova, Dulce María Carrillo-Córdova
INTRODUCTION: portal hypertension and variceal hemorrhage are common complications of hepatic cirrhosis, both associated with a high morbimortality. Portal system decompression by the placement of a transjugular intrahepatic portosystemic stented shunt, can reduce portal venus pressure and is effective controling complications of portal hypertension, like variceal hemorrhage and ascitis. The aim of this document is to describe a case of hemolytic anemia secondary to the placement of a transjugular intrahepatic portosystemic stented shunt...
March 2013: Cirugia y Cirujanos
I Păun, D Mogoş, M Păun, M Teodorescu, M Florescu, M Tenovici, G Mogoş
This paper draws attention towards 3 cases with different pathologies all of which suggesting however both clinically and by imaging means as the most likely diagnosis advanced-stage epithelial ovarian cancer since all these three postmenopausal women had been admitted to the hospital with ascites, pelvic masses and deterioration of the physical wellbeing (fatigue, decreased appetite, weight loss, pallor). Findings during exploratory laparotomy on all these three pacients included ascites (hemorragic in one case) diffuse tumorous implants throughout the abdominal and pelvic peritoneal surfaces (in two cases) and the ovarian tumour...
July 2010: Chirurgia
Agata Budkowska
Hepatitis C virus (HCV) is an enveloped, single-stranded RNA virus, belonging to the Flaviviridae family. HCV infection is a major cause of chronic hepatitis worldwide, leading to steatosis, liver cirrosis and hepatocellular carcinoma. Significant advances in understanding the mechanisms of HCV infection have been made since the development of a cell culture system reproducing the complete HCV cell cycle in vitro. HCV represents a new paradigm in interactions between the virus and its target cell, the human hepatocyte, due to the central role of lipoproteins in the HCV life cycle...
2009: Polish Journal of Microbiology
Vicens Diaz-Brito, Helder Cardoso, António Sarmento
Cirrhosis is the terminal phase of hepatic fibrosis, that leads to impaired hepatic function and blood flow. Liver cirrhosis is the final stage of many hepatic diseases characterized by chronic cellular destruction. The complications of liver cirrosis are the result of the hepatocellular lesion and portal hypertension. The most frequent complications are ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, gastroesophageal varices, portal hypertensive gastropathy, hypersplenism, hepatocellular carcinoma, methabolic disorders, hepatorenal syndrome and hepatopulmonary syndrome...
March 2008: Acta Médica Portuguesa
V A Osina, T N Kuz'mina
The present article gives evidence-based recommendations for the indication, application and type of formula of enteral nutrition (EN) (oral nutrition supplements (ONS) or tube feeding (TF)) in patients with Crohn's disease (CD), ulcerative colitis (UC), short bowel syndrome (SBS), acute and chronic pancreatitis, alcoholic steatogepatitis and cirrosis. ONS and/or TF in addition to normal food is indicates in undernourished patients with CD or UC to improve nutritional status. In active CD EN is the first line therapy in children and should be used as sole therapy in adults mainly when treatment with corticosteroids is not feasible...
2007: Experimental & Clinical Gastroenterology
Joanna Pawłowska, Piotr Kaliciński, Irena Jankowska, Mikołaj Teisseyre, Joanna Teisseyre, Diana Kamińska, Paweł Nachulewicz, Małgorzata Markiewicz-Kijewska, Jerzy Socha
THE AIM: of the study was to analyse the first 102 living-related liver transplantations performed in Poland at the Children's Memorial Health Institute. MATERIAL: between November 1999 and January 2007 102 living-related liver transplantations were carried out in 101 patients. In 63 the patients the indication for liver transplantation was biliary atresia, in 7 - intrahepatic cholestasis, in 11 - acute liver failure, in 9 - hepatic tumour, in two - graft insufficiency...
April 2007: Medycyna Wieku Rozwojowego
Bin Liu, Lu-Nan Yan, Wen-Tao Wang, Bo Li, Yong Zeng, Tian-Fu Wen, Ming-Qing Xu, Jia-Yin Yang, Zhe-Yu Chen, Ji-Chun Zhao, Yu-Kui Ma, Jiang-Wen Liu, Hong Wu
AIM: To investigate the safety of adult-to-adult living donor liver transplantation (A-A LDLT) in both donors and recipients. METHODS: From January 2002 to July 2006, 50 cases of A-A LDLT were performed at West China Hospital, Sichuan University, consisting of 47 cases using right lobe graft without middle hepatic vein (MHV), and 3 cases using dual grafts (one case using two left lobe, 2 using one right lobe and one left lobe). The most common diagnoses were hepatitis B liver cirrosis, 30 (60%) cases; and hepatocellular carcinoma, 15 (30%) cases in adult recipients...
February 14, 2007: World Journal of Gastroenterology: WJG
G P Cione, G Arciero, C P De Angelis, A Marano, N Farella, C Cerrone, D Cerbone, D Parmeggiani, G Cimmino, M Perrotta, D Giglio
The primitive tumors of the liver are relatively rare in the Western countries (around the 0.7% of all the neoplasms) while they present more elevated incidence in Africa and in the South Asian East. While the hepatocellular carcinoma rises up in the 50-70% of the cases in livers cirrosis, this correlation is not valid for the form of carcinoma to departure from the learned intra and extra biliar. The etiology of the intrahepatic colangiocarcinoma (CC) stays unknown. They have stayed observe, on the other hand, of the conditions sometimes correlated to the development of the CC (Carolí morbs, ulcerative colitis, asbestosis)...
May 2005: I Supplementi di Tumori: Official Journal of Società Italiana di Cancerologia ... [et Al.]
M Rivera, J Lucero, A Guerrero, J L Márquez, R Montes, M Suñer, A Ruiz, M A Valdivia, J Mateos
Angiodysplasia is an important cause of gastrointestinal bleeding in patients with chronic renal failure. Octreotide, a long-acting synthetic somatostatin analogue that reduces splachnic blood flow have been used to treat esophageal varicose hemorrhage, but its efficacy for bleeding vascular ecstasies is awaiting support. We present three patients with chronic renal failure (two with diabetic nephropaty and the third with mesangiocapilar glomerulonephritis and hepatic cirrosis), seric creatinine 3-4,5 mg/dl, and recurrent gastrointestinal bleeding due to diffuse angiodysplasia and vascular ecstasies, diagnosed by oral endoscopy, colonoscopy and video capsule...
2005: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
No abstract text is available yet for this article.
September 1960: Archivio "de Vecchi" Per L'anatomia Patologica e la Medicina Clinica
Félix García Ahumada, Eleazar Antúnez De Mayolo, Martín Morales Delgado
47 liver biopsies with anatomopathologial diagnosis of cirrhosis were processed by immunoperoxidase (IP) to determine the presence of HBsAg. This highly sensible and specific method has been very seldom used in our media before.Biopsies were classified into two groups: postnecrotic hepatic cirrosis (PN) (37) and non postnecrotic hepatic cirrhosis (NP) (10). Nine biopsies were IP positive and represent 19.15% from the whole population and all of them belong to PN hepatic cirrhosis.This technique is proposed as an auxiliary method when confronting diagnostic problems, and specially in tissues of endemic zones...
April 2000: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
E Brullet, J Espinós, R Campo, J M Viver, X Calvet, M Forné, B Dalmau, A Fernández, M Gil, J J Canet, Y P Mas
The aim of the present study was to determine the usefulness of elastic band ligation in the prevention of hemorrhage recurrence by esophageal varices. Forty-five patients without known hepatocarcinoma who had survived a hemorrhagic variceal episode were included in the study. Seventeen patients (38%) were Child-Pugh A, 22 (49%) B, and 6 (13%) C, with the hepatitis C virus and alcohol being the etiology of cirrosis in 55 and 20% of the cases, respectively. The first ligation session was performed between the third and fifth days after the hemorrhagic episode and the posterior sessions were carried out at intervals of 2-4 weeks...
August 1996: Gastroenterología y Hepatología
J Inoue, Y Mori, T Kawamura
No abstract text is available yet for this article.
November 1969: Naika. Internal Medicine
A V Galkin
The term "alcohol hyalin" designates several types of acidophilic inclusions in the cytoplasm of hepatocytes in acute alcoholic hepatitis. While similar material occurs in a number of non-alcoholic hepatopathies and extrahepatically, alcohol hyalin serves as an important marker of the alcohol-induced liver disease. Alcohol hyalin is mainly a protein material (fibrillar or granular) containing a number of polypeptides related to cytokeratin system, as well as some unique components. Its formation has multiple pathologic consequences including necrosis of hepatocytes, inflammatory processes in the liver resulting in cirrosis, and systemic autoimmune disorders...
1986: Arkhiv Patologii
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