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https://www.readbyqxmd.com/read/29775004/-detection-of-differentially-expressed-gene-of-allergic-rhinitis-based-on-rt%C3%A2-profiler-pcr-array
#1
Y Peng, X Q Li, Q H Qiu
Objective: The aim of this study is to detect differentially expressed gene of allergic rhinitis (AR) based on RT² profiler PCR array. Method: The real-time PCR array containing 84 genes were used to compare inferior turbinate samples obtained from AR patients (n=8) and healthy individuals (n=8). Result: The results showed that 67 genes were down regulated and 17 genes were up regulated in AR inferior turbinate after analysis of 84 genes related to allergy and asthma. STAT6 and BCL6 were recognized as differentially expressed genes...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29773845/aicar-inhibits-nf%C3%AE%C2%BAb-dna-binding-independently-of-ampk-to-attenuate-lps-triggered-inflammatory-responses-in-human-macrophages
#2
Johannes Kirchner, Bernhard Brüne, Dmitry Namgaladze
5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated protein kinase (AMPK). Both, AICAR and AMPK were reported to attenuate inflammation. However, AICAR is known for many AMPK-independent effects, although the mechanisms remain incompletely understood. Here we report a potent suppression of lipopolysaccharide (LPS)-induced inflammatory gene expression by AICAR in primary human macrophages, which occurred independently of its conversion to AMPK-activating 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl monophosphate...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29771943/cross-talk-between-human-airway-epithelial-cells-and-3t3-j2-feeder-cells-involves-partial-activation-of-human-met-by-murine-hgf
#3
Robert E Hynds, Kate H C Gowers, Ersilia Nigro, Colin R Butler, Paola Bonfanti, Adam Giangreco, Cecilia M Prêle, Sam M Janes
There is considerable interest in the ex vivo propagation of primary human basal epithelial stem/progenitor cells with a view to their use in drug development, toxicity testing and regenerative medicine. These cells can be expanded in co-culture with mitotically inactivated 3T3-J2 murine embryonic feeder cells but, similar to other epithelial cell culture systems employing 3T3-J2 cells, the aspects of cross-talk between 3T3-J2 cells and human airway basal cells that are critical for their expansion remain largely unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29770139/spermine-alleviates-acute-liver-injury-by-inhibiting-liver-resident-macrophage-pro-inflammatory-response-through-atg5-dependent-autophagy
#4
Shun Zhou, Jian Gu, Rui Liu, Song Wei, Qi Wang, Hongbing Shen, Yifan Dai, Haoming Zhou, Feng Zhang, Ling Lu
Liver-resident macrophages (Kupffer cells, KCs) and autophagy play critical roles in the pathogenesis of toxin-induced liver injury. Recent evidence indicates that autophagy can regulate macrophage M1/M2 polarization under different inflammatory conditions. Polyamines, including putrescine, spermidine, and spermine (SPM), are polycations with anti-oxidative, anti-aging, and cell autophagy induction properties. This study aimed to determine the mechanisms by which SPM protects against thioacetamide (TAA)-induced acute liver injury in a mouse model...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29757188/microrna-210-overexpression-promotes-psoriasis-like-inflammation-by-inducing-th1-and-th17-cell-differentiation
#5
Ruifang Wu, Jinrong Zeng, Jin Yuan, Xinjie Deng, Yi Huang, Lina Chen, Peng Zhang, Huan Feng, Zixin Liu, Zijun Wang, Xiaofei Gao, Haijing Wu, Honglin Wang, Yuwen Su, Ming Zhao, Qianjin Lu
Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular mechanisms underlying this aspect of psoriasis pathology are poorly understood. Here, we report that microRNA-210 (miR-210), a miR that is highly expressed in both psoriasis patients and mouse models, induces helper T (Th) 17 and Th1 cell differentiation but inhibits Th2 differentiation through repressing STAT6 and LYN expression, contributing to several aspects of the immune imbalance in psoriasis. Both miR-210 ablation in mice and inhibition of miR-210 by intradermal injection of antagomir-210 blocked the immune imbalance and the development of psoriasis-like inflammation in an imiquimod-induced or IL-23-induced psoriasis-like mouse model...
May 14, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29756681/neuronal-il-4r%C3%AE-modulates-neuronal-apoptosis-and-cell-viability-during-the-acute-phases-of-cerebral-ischemia
#6
Han Kyu Lee, Sehwon Koh, Donald C Lo, Douglas A Marchuk
Ischemic stroke caused by an embolus or local thrombosis results in neural tissue damage (an infarct) in the territory of the occluded cerebral artery. Decades of studies have increased our understanding of the molecular events during cerebral infarction; however, translation of these discoveries to druggable targets for ischemic stroke treatment has been largely disappointing. Interleukin-4 (IL-4) is a multifunctional cytokine that exerts its cellular activities via the interleukin-4 receptor α (IL-4Rα)...
May 14, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29752758/src-type-tyrosine-kinase-p56lck-is-critical-for-thymic-stromal-lymphopoietin-induced-allergic-rhinitis
#7
Sun-Young Nam, Hee-Yun Kim, Na-Ra Han, Phil-Dong Moon, Joong-Saeng Cho, Hyung-Min Kim, Hyun-Ja Jeong
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is a regulator of mast cell-mediated allergic inflammatory reactions, but the manner in which TSLP contributes to allergic rhinitis (AR) remains unclear. OBJECTIVE: Here we sought to determine that TSLP plays a crucial role in AR by interacting with Src-type tyrosine kinase p56lck and STAT6 and promoting mast cells degranulation. METHODS: The effects of TSLP on mast cell degranulation and AR were analyzed in human mast cell line (HMC-1 cells), ovalbumin (OVA)-induced AR animal model, and human subjects...
May 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29739850/small-molecule-targeting-of-the-stat5-6-src-homology-2-sh2-domains-to-inhibit-allergic-airway-disease
#8
J Morgan Knight, Pijus Mandal, Pietro Morlacchi, Garbo Mak, Evan Li, Matthew Madison, Cameron Landers, Brandon Saxton, Ed Felix, Brian Gilbert, Joel Sederstrom, Atul Varadhachary, Melissa M Singh, Dev Chatterjee, David B Corry, John S McMurray
Asthma is a chronic inflammatory disease of the lungs and airways and one of the most burdensome of all chronic maladies. Previous studies have established that expression of experimental and human asthma requires the IL-4/IL-13/IL-4 receptor alpha (IL-4Rα) signaling pathway, which activates the transcription factor STAT6. However, no small molecules targeting this important pathway are currently in clinical development. To this end, using a preclinical asthma model, we sought to develop and test a small-molecule inhibitor of the Src homology 2 domains in mouse and human STAT6...
May 8, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29739101/stat1-and-stat6-act-as-antagonistic-regulators-of-ppar%C3%AE-in-diabetic-patients-with-and-without-cardiovascular-diseases
#9
Imen Bendaya, Aouatef Riahi, Maher Kharat, Saloua Kahla, Wissem Sdiri, Ridha Oueslati
BACKGROUND: The processes that mediate an inflammatory environment and increase atherosclerosis in diabetes are not well understood. Peroxisome proliferator-activated receptors (PPARs) are a subgroup of the nuclear hormone receptor superfamily of ligand-activated transcription factors which play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) and atherosclerosis. PPARγ promotes changes in lipid metabolism, especially in fatty acid (FA) trafficking, and the activity of PPARγ could be modulated by diabetes phenotype patients...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738764/recirculating-th2-cells-induce-severe-thymic-dysfunction-via-il-4-stat6-signaling-pathway
#10
Hui Shen, Chen Yin, Ya-Nan Gao, Xiao-Yan Pei, Xiu-Yuan Sun, Qing Ge, Wei Wang, Yu Zhang
Thymic involution happened early in life, but a certain ratio of activated CD4+ T cells will persistently recirculate into the thymus from the periphery and it have been suggested to be able to inhibit the development of embryonic thymocytes. Our present study was aimed to elucidate the specific mechanism how activated CD4+ T cells could influence upon developing thymocytes by using fetal thymic organ culture (FTOC) and kidney capsule transplantation. Our results demonstrated that Th2 cells were found to play a fundamental role in the inhibition of embryonic thymocyte development since a very low concentration of Th2 cells could obviously reduce the total number of thymocytes...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29730267/imatinib-prevents-lung-cancer-metastasis-by-inhibiting-m2-like-polarization-of-macrophages
#11
Zhangting Yao, Jieqiong Zhang, Bo Zhang, Guikai Liang, Xi Chen, Fengqi Yao, Xiaqing Xu, Honghai Wu, Qiaojun He, Ling Ding, Bo Yang
Although M2-like tumor-associated macrophages (TAMs) have been considered as a vital therapeutic target in cancer therapy due to their role in promoting tumor progression and metastasis, very few compounds have been identified to inhibit M2-like polarization of TAMs. Here, we showed that Imatinib significantly prevented macrophage M2-like polarization induced by IL-13 or IL-4 in vitro, as illustrated by reduced expression of cell surface marker CD206 and M2-like genes, including Arg1, Mgl2, Mrc1, CDH1, and CCL2...
May 3, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29729938/slc9a3-nhe3-dysregulation-and-dilated-intercellular-spaces-in-eosinophilic-esophagitis
#12
Chang Zeng, Simone Vanoni, David Wu, Julie M Caldwell, Justin C Wheeler, Kavisha Arora, Taeko K Noah, Lisa Waggoner, John A Besse, Amnah N Yamani, Jazib Uddin, Mark Rochman, Ting Wen, Mirna Chehade, Margaret Collins, Vincent Mukkada, Philip Putnam, Anjaparavanda P Naren, Marc E Rothenberg, Simon P Hogan
BACKGROUND: Eosinophilic esophagitis (EoE) is characterized by histopathologic modifications of esophageal tissue including eosinophil-rich inflammation, basal zone hyperplasia (BZH) and dilated intercellular spaces (DIS). The underlying molecular processes that drive the histopathologic features of EoE remain largely unexplored. OBJECTIVE: To investigate the involvement of SLC9A3 in esophageal epithelial [pH]i and DIS formation and the histopathological features of EoE...
May 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29704593/treg-dysfunction-induces-autoantibodies-to-bullous-pemphigoid-antigens-in-mice-and-humans
#13
Ken Muramatsu, Hideyuki Ujiie, Ichiro Kobayashi, Wataru Nishie, Kentaro Izumi, Takamasa Ito, Norihiro Yoshimoto, Ken Natsuga, Hiroaki Iwata, Hiroshi Shimizu
BACKGROUND: Regulatory T cells (Tregs) play a crucial role in peripheral immune tolerance in multiple organs, including the skin. Thus far, the impact of peripheral immune tolerance failure on autoantibody-related autoimmune reaction to the skin is unclear. OBJECTIVE: We sought to elucidate the target autoantigens in the skin under the condition of Treg dysfunction due to Foxp3 gene mutations in scurfy mice and patients with immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome...
April 25, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29703864/farnesyltransferase-inhibition-exacerbates-eosinophilic-inflammation-and-airway-hyperreactivity-in-mice-with-experimental-asthma-the-complex-roles-of-ras-gtpase-and-farnesylpyrophosphate-in-type-2-allergic-inflammation
#14
Jennifer M Bratt, Kevin Y Chang, Michelle Rabowsky, Lisa M Franzi, Sean P Ott, Simone Filosto, Tzipora Goldkorn, Muhammad Arif, Jerold A Last, Nicholas J Kenyon, Amir A Zeki
Ras, a small GTPase protein, is thought to mediate Th2-dependent eosinophilic inflammation in asthma. Ras requires cell membrane association for its biological activity, and this requires the posttranslational modification of Ras with an isoprenyl group by farnesyltransferase (FTase) or geranylgeranyltransferase (GGTase). We hypothesized that inhibition of FTase using FTase inhibitor (FTI)-277 would attenuate allergic asthma by depleting membrane-associated Ras. We used the OVA mouse model of allergic inflammation and human airway epithelial (HBE1) cells to determine the role of FTase in inflammatory cell recruitment...
April 27, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29703757/telomerase-promoter-mutations-and-copy-number-alterations-in-solitary-fibrous-tumours
#15
Yingbo Lin, Nelly Seger, Panagiotis Tsagkozis, Asle C Hesla, Mehran Ghaderi, Yi Chen, Monika Ehnman, Dudi Warsito, Johan Wejde, Olle Larsson, Felix Haglund
AIMS: Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the NAB2-STAT6 fusion gene. Activating mutations in the telomerase reverse transcriptase ( hTERT ) gene promoter has been reported to associate with adverse patient outcome in SFTs. METHODS: We analysed the hTERT gene for promoter mutations and copy number alterations in 43 primary extrameningeal SFTs (9 malignant and 34 benign tumours according to WHO 2013 criteria), six local recurrences and three metastatic lesions...
April 27, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29700673/pazopanib-efficacy-in-recurrent-central-nervous-system-hemangiopericytomas
#16
Caroline Apra, Agusti Alentorn, Karima Mokhtari, Michel Kalamarides, Marc Sanson
INTRODUCTION: There is currently no treatment for solitary fibrous tumors/hemangiopericytomas (SFT/H) of the central nervous system recurring after multiple surgeries and radiotherapies. The NAB2-STAT6 gene fusion is the hallmark of these tumors, and upregulates Early Growth Factor, activating several growth pathways. METHODS: We treated two patients presenting pluri-recurrent meningeal SFT/H with Pazopanib, a broad-spectrum tyrosine kinase inhibitor. We analyzed the exome and RNA sequencing data of one of them and, in addition to another meningeal SFT/H, compared it to the transcriptomic profiling of 5 systemic SFT/H...
April 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29698782/altered-cytokine-profile-under-control-of-the-serotonergic-system-determines-the-regulation-of-cyp2c11-and-cyp3a-isoforms
#17
Marta Kot, Martine Daujat-Chavanieu
The aim of this study is to assess a potential mechanism by which the serotonergic system can control the expression and activity of cytochrome (CYP) 2C11 and CYP3A isoforms during liver insufficiency. A rat model of diethylnitrosamine (DEN)-induced liver insufficiency was developed by administering 50 mg/kg of DEN twice a week for 7 weeks. Dysfunction of the serotonergic system was evoked by feeding the rats with a tryptophan-free diet for three weeks. Dysfunction of the serotonergic system during liver insufficiency decreased the level of proinflammatory cytokines (TGF-β and IL-1β) and increased the level of an anti-inflammatory cytokine (IL-4)...
April 23, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29695237/amphotericin-b-suppresses-m2-phenotypes-and-b7-h1-expression-in-macrophages-to-prevent-raji-cell-proliferation
#18
Jing Zhang, Dongqing Cao, Shuangquan Yu, Lingchao Chen, Daolin Wei, Chang Shen, Lin Zhuang, Qian Wang, Xiaoping Xu, Yin Tong
BACKGROUND: Macrophages in the tumor microenvironment play a critical role in tumorigenesis and anti-cancer drug resistance. Burkitt's lymphoma (BL) is a B-cell non-Hodgkin's lymphoma with dense macrophage infiltration. However, the role for macrophages in BL remains largely unknown. METHODS: B7-H1, a transmembrane glycoprotein in the B7 family, suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. The expression of B7-H1 in BL clinical tissues was determined by streptavidin-peroxidase immunohistochemistry...
April 26, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29690665/-spindle-cell-lipoma-and-pleomorphic-lipoma-a-clinicopathologic-analysis-of-65-cases
#19
L H Tang, Q Y Lao, L Yu, J Wang
Objective: To investigate the clinical and pathological features of spindle cell lipoma (SCL) and pleomorphic lipoma (PL) with emphasis on differential diagnosis. Methods: Sixty-five cases of SCL/PL from the archive of Department of Pathology, Fudan University Shanghai Cancer Center, from August of 2006 to June of 2017, were included in the study. Immunohistochemistry by EnVision method, MDM2 gene amplifycation and DDIT3 gene translocation by fluorescence in situ hybridization(FISH) were detected and the literature was reviewed...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29689243/whole-exome-sequencing-identifies-unique-mutations-and-copy-number-losses-in-calcifying-fibrous-tumor-of-the-pleura-report-of-three-cases-and-review-of-the-literature
#20
Mitra Mehrad, William A LaFramboise, Maureen A Lyons, Humberto E Trejo Bittar, Samuel A Yousem
Calcifying fibrous tumor of the pleura (CFTP) is a rare mesenchymal tumor of unknown pathogenesis. The diagnosis often requires exclusion of other common entities. Our aim was to determine if genomic changes were associated with CFTP that could contribute to mechanisms underlying tumorigenesis. Three cases of CFTP with their corresponding uninvolved control lung tissue were identified. Two patients were male, and one was female (age range: 21-32years). Tumors were multifocal in two cases and solitary in one...
April 21, 2018: Human Pathology
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