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https://www.readbyqxmd.com/read/27913199/the-involvement-of-m2-macrophage-polarization-inhibition-in-fenretinide-mediated-chemopreventive-effects-on-colon-cancer
#1
Rong Dong, Yanling Gong, Wen Meng, Meng Yuan, Hong Zhu, Meidan Ying, Qiaojun He, Ji Cao, Bo Yang
Clinical studies have shown that fenretinide (4-HPR) is an attractive chemopreventive agent for cancer treatment. However, to date, few studies have demonstrated the mechanism of the preventive effect of 4-HPR. In our current study, we revealed that 4-HPR could significantly suppress IL-4/IL-13 induced M2-like polarization of macrophages, which was demonstrated by the reduced expression of M2 surface markers, the down-regulation of M2 marker genes, and the inhibition of M2-like macrophages promoted angiogenesis...
November 29, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27906181/stat6-deficiency-ameliorates-graves-disease-severity-by-suppressing-thyroid-epithelial-cell-hyperplasia
#2
Xuechao Jiang, Bingbing Zha, Xiaoming Liu, Ronghua Liu, Jun Liu, Enyu Huang, Tingting Qian, Jiajing Liu, Zhiming Wang, Dan Zhang, Luman Wang, Yiwei Chu
Signal transducer and activator of transcription 6 (STAT6) is involved in epithelial cell growth. However, little is known regarding the STAT6 phosphorylation status in Graves' disease (GD) and its role in thyroid epithelial cells (TECs). In this study, we found that STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both GD patients and experimental autoimmune Graves' disease mice and that STAT6 deficiency ameliorated GD symptoms. Autocrine IL-4 signalling in TECs activated the phosphorylation of STAT6 via IL-4 R engagement, and the downstream targets of STAT6 were Bcl-xL and cyclin D1...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27899095/effects-of-the-ayurved-siriraj-wattana-recipe-on-functional-and-phenotypic-characterization-of-cytokine-induced-killer-cells-and-dendritic-cells-in-vitro
#3
Adisak Wongkajornsilp, Nuntarak Numchaisermsuk, Khanit Sa-Ngiamsuntorn, Pravit Akarasereenont, Valla Wamanuttajinda, Kanda Kasetsinsombat, Sunisa Duangsa-Ard, Tawee Laohapan, Kittipong Maneechotesuwan
BACKGROUND: Ayurved Siriraj Wattana recipe (AVS073), has been prescribed as tonic, to increase appetite, and for pain relief. It also exhibits antioxidant, anti-inflammatory, immunomodulating and anti-cancer activities. However, the immunomodulatory effects on antigen-presenting cells and effector T cells remained elusive. We thus aimed to study the effects of AVS073 on differentiation, maturation, functions and proportions of CIK cells and monocyte-derived DCs. METHODS: CIK cells and monocyte-derived DCs were treated with AVS073, followed by the assessment of T-helper (Th) phenotypes using real-time RT-PCR and flow cytometry...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27895317/il-4-a-direct-target-of-mir-340-429-is-involved-in-radiation-induced-aggressive-tumor-behavior-in-human-carcinoma-cells
#4
Eun Sook Kim, Young Eun Choi, Su Jin Hwang, Young-Hoon Han, Myung-Jin Park, In Hwa Bae
Radiotherapy induces the production of cytokines, thereby increasing aggressive tumor behavior. This radiation effect results in the failure of radiotherapy and increases the mortality rate in patients. We found that interleukin-4 (IL-4) and IL-4Rα (IL-4 receptor) are highly expressed in various human cancer cells subsequent to radiation treatment. In addition, IL-4 is highly overexpressed in metastatic carcinoma tissues compared with infiltrating carcinoma tissues. High expression of IL-4 in patients with cancer is strongly correlated with poor survival...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27865862/impaired-mucus-clearance-exacerbates-allergen-induced-type-2-airway-inflammation-in-juvenile-mice
#5
Benedikt Fritzsching, Matthias Hagner, Lu Dai, Sandra Christochowitz, Raman Agrawal, Charlotte van Bodegom, Simone Schmidt, Jolanthe Schatterny, Stephanie Hirtz, Ryan Brown, Michelle Goritzka, Julia Duerr, Zhe Zhou-Suckow, Marcus A Mall
BACKGROUND: Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly understood. We recently demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces spontaneous type 2 airway inflammation in juvenile Scnn1b-transgenic (Scnn1b-Tg) mice. OBJECTIVE: To determine the role of impaired mucus clearance in the pathogenesis of allergen-induced type 2 airway inflammation and identify cellular sources of the signature cytokine IL-13...
November 16, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27861999/forkhead-box-protein-3-foxp3-producing-dendritic-cells-suppress-allergic-response
#6
Xiao-Yu Liu, Ling-Zhi Xu, Xiang-Qian Luo, Xiao-Rui Geng, Zhi-Qiang Liu, Li-Teng Yang, Gui Yang, Si Chen, Zhi-Gang Liu, Hua-Bin Li, Li-Tao Yang, Tian-Gang Luan, Ping-Chang Yang
BACKGROUND: The generation of the tolerogenic dendritic cells (DC) is not fully understood yet. Forkhead box protein-3 (Foxp3) is an important molecule in the immune tolerance. This study tests a hypothesis that DCs express Foxp3, which can be up regulated by Staphylococcal enterotoxin B (SEB). METHODS: The expression of Foxp3 by DCs was evaluated by real time RT-PCR, Western blotting, flow cytometry and chromatin immunoprecipitation assay. RESULTS: We observed that mice treated with SEB at 0...
November 15, 2016: Allergy
https://www.readbyqxmd.com/read/27858144/th9-and-other-il-9-producing-cells-in-allergic-asthma
#7
REVIEW
Sonja Koch, Nina Sopel, Susetta Finotto
Allergic asthma is a worldwide increasing chronic disease of the airways which affects more than 300 million people. It is associated with increased IgE, mast cell activation, airway hyperresponsiveness (AHR), mucus overproduction and remodeling of the airways. Previously, this pathological trait has been associated with T helper type 2 (Th2) cells. Recently, different CD4(+) T cell subsets (Th17, Th9) as well as cells of innate immunity, like mast cells and innate lymphoid cells type 2 (ILC2s), which are all capable of producing the rediscovered cytokine IL-9, are known to contribute to this disease...
November 17, 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/27848951/genetic-deletion-of-the-bacterial-sensor-nod2-improves-murine-crohn-s-disease-like-ileitis-independent-of-functional-dysbiosis
#8
D Corridoni, A Rodriguez-Palacios, G Di Stefano, L Di Martino, D A Antonopoulos, E B Chang, K O Arseneau, T T Pizarro, F Cominelli
Although genetic polymorphisms in NOD2 (nucleotide-binding oligomerization domain-containing 2) have been associated with the pathogenesis of Crohn's disease (CD), little is known regarding the role of wild-type (WT) NOD2 in the gut. To date, most murine studies addressing the role of WT Nod2 have been conducted using healthy (ileitis/colitis-free) mouse strains. Here, we evaluated the effects of Nod2 deletion in a murine model of spontaneous ileitis, i.e., the SAMP1Yit/Fc (SAMP) strain, which closely resembles CD...
November 16, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27845069/mechanism-of-corilagin-interference-with-il-13-stat6-signaling-pathways-in-hepatic-alternative-activation-macrophages-in-schistosomiasis-induced-liver-fibrosis-in-mouse-model
#9
Peng Du, Qian Ma, Zhi-De Zhu, Gang Li, Yao Wang, Quan-Qiang Li, Yun-Fei Chen, Zhen-Zhong Shang, Juan Zhang, Lei Zhao
This study tried to find the mechanism of Corilagin interference with interleukin (IL)-13/signal transducer and activator of transcription (STAT) 6 signaling pathways in IL-13-activated liver alternative activation macrophages in schistosomiasis-induced liver fibrosis in Balb/c mice. As a result, IL-13 in serum and the mRNA expression of IL-13 Receptor α1, IL-4 Receptor α and downstream mediators supressor of cytokine signaling (SOCS) 1, Kruppel-like factor (KLF) 4, peroxisome proliferator-activated receptor (PPAR) δ in the liver tissue were significantly inhibited by Corilagin (P<0...
December 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27825811/superficial-acral-fibromyxoma-clinicopathologic-immunohistochemical-and-molecular-study-of-11-cases-highlighting-frequent-rb1-loss-deletions
#10
Abbas Agaimy, Michael Michal, Johannes Giedl, Ladislav Hadravsky, Michal Michal
Superficial acral fibromyxoma (SAF) is an uncommon benign dermal mesenchymal lesion of adults with predilection for acral sites, in particular the nail region. To date, <300 cases have been reported. SAFs consistently express CD34 but other diagnostic markers or specific genetic alterations have not been established yet. We describe 11 SAFs occurring in 7 males and 4 females aged 37 to 86years (median, 48). Mean size was 6mm (range, 4-20mm). Affected sites were fingers (n=5), toes (n=3), heel (n=1), calf (n=1) and unspecified digit (n=1)...
November 4, 2016: Human Pathology
https://www.readbyqxmd.com/read/27815425/stat6-regulates-the-development-of-eosinophilic-versus-neutrophilic-asthma-in-response-to-alternaria-alternata
#11
Andrea C Valladao, Charles W Frevert, Lisa K Koch, Daniel J Campbell, Steven F Ziegler
Human asthma is a heterogeneous disease characterized by the expression of both Th2 and Th17 cytokines. In vitro and in vivo studies have shown a reciprocal regulation between Th2 and Th17 pathways, suggesting a potential induction of neutrophil-promoting Th17 inflammation in the absence of a Th2 response. Alternaria alternata is a clinically relevant allergen that is associated with severe and fatal asthma exacerbations. Exposure to A. alternata is characterized by a predominant Th2 response, but can also induce the production of factors associated with Th17 responses (e...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27813070/atopic-dermatitis-a-tale-of-two-distinct-pathomechanisms-that-make-you-itch
#12
Edward F Knol, DirkJan Hijnen
Atopic dermatitis (AD) or eczema is the most common chronic inflammatory skin disease. It is a multifactorial disease with local and systemic immune changes. Current therapies focus on restoring the local skin barrier or inhibiting immune responses. In this issue of the European Journal of Immunology, Sehra et al. [Eur. J. Immunol. 2016. 46:2609-2613] describe a mouse model with T-cell-specific expression of constitutively active Stat6 in Flaky tail mice, which have mutations in the Flg and Tmem79 genes. The authors describe that it is the combination of changes in the skin barrier proteins filaggrin and Tmem79, together with Th2 cytokine signaling in the constitutively active Stat6 transgene, that drives the immune-pathomechanism in AD...
November 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27811935/integrated-computational-approach-to-the-analysis-of-rna-seq-data-reveals-new-transcriptional-regulators-of-psoriasis
#13
Alena Zolotarenko, Evgeny Chekalin, Alexandre Mesentsev, Ludmila Kiseleva, Elena Gribanova, Rohini Mehta, Ancha Baranova, Tatiana V Tatarinova, Eleonora S Piruzian, Sergey Bruskin
Psoriasis is a common inflammatory skin disease with complex etiology and chronic progression. To provide novel insights into the regulatory molecular mechanisms of the disease, we performed RNA sequencing analysis of 14 pairs of skin samples collected from patients with psoriasis. Subsequent pathway analysis and extraction of the transcriptional regulators governing psoriasis-associated pathways was executed using a combination of the MetaCore Interactome enrichment tool and the cisExpress algorithm, followed by comparison to a set of previously described psoriasis response elements...
November 4, 2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27808402/differential-expression-of-estrogen-receptor-variants-in-response-to-inflammation-signals-in-human-airway-smooth-muscle
#14
Bharathi Aravamudan, Katelyn J Goorhouse, Ghanashyam Unnikrishnan, Michael A Thompson, Christina M Pabelick, John R Hawse, Y S Prakash, Venkatachalem Sathish
The prevalence of asthma is higher in pre-pubescent and aging males, and in post-pubertal females, strongly indicating that sex steroids (especially estrogen) may be an important modulator in lung disease. We recently demonstrated that airway smooth muscle (ASM) expresses both alpha and beta forms of the estrogen receptor (ERα and ERβ) in males and females, and that these receptors regulate intracellular [Ca2 +] and ASM contractility. While both ERα and ERβ have multiple splice variants, it is unclear if and how the expression of these variants is modulated under conditions such as chronic inflammation/ asthma...
November 3, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27803324/structural-basis-for-dna-recognition-by-stat6
#15
Jing Li, Jose Pindado Rodriguez, Fengfeng Niu, Mengchen Pu, Jinan Wang, Li-Wei Hung, Qiang Shao, Yanping Zhu, Wei Ding, Yanqing Liu, Yurong Da, Zhi Yao, Jie Yang, Yongfang Zhao, Gong-Hong Wei, Genhong Cheng, Zhi-Jie Liu, Songying Ouyang
STAT6 participates in classical IL-4/IL-13 signaling and stimulator of interferon genes-mediated antiviral innate immune responses. Aberrations in STAT6-mediated signaling are linked to development of asthma and diseases of the immune system. In addition, STAT6 remains constitutively active in multiple types of cancer. Therefore, targeting STAT6 is an attractive proposition for treating related diseases. Although a lot is known about the role of STAT6 in transcriptional regulation, molecular details on how STAT6 recognizes and binds specific segments of DNA to exert its function are not clearly understood...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27803134/gene-expression-profiling-in-blood-and-affected-muscle-tissues-reveals-differential-activation-pathways-in-patients-with-new-onset-juvenile-and-adult-dermatomyositis
#16
Consuelo M López De Padilla, Cynthia S Crowson, Molly S Hein, Richard S Pendegraft, Michael A Strausbauch, Timothy B Niewold, Floranne C Ernste, Erik Peterson, Emily C Baechler, Ann M Reed
OBJECTIVE: To identify shared and differential molecular pathways in blood and affected muscle between adult dermatomyositis (DM) and juvenile DM, and their association with clinical disease activity measures. METHODS: Gene expression of transcription factors and cytokines involved in differentiation and effector function of T cell subsets, regulatory T cells and follicular Th cells, were analyzed in the blood from 21 newly diagnosed adult and 26 juvenile DM subjects and in 15 muscle specimens (7 adult and 8 juvenile DM) using a custom RT2 Profiler PCR Array...
November 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27802414/solitary-fibrous-tumour-of-the-genitourinary-tract-a-clinicopathological-study-of-11-cases-and-their-association-with-the-nab2-stat6-fusion-gene
#17
Erik Kouba, Novae B Simper, Shaoxiong Chen, Sean R Williamson, David J Grignon, John N Eble, Gregory T MacLennan, Rodolfo Montironi, Antonio Lopez-Beltran, Adeboye O Osunkoya, Shaobo Zhang, Mingsheng Wang, Lisha Wang, Thu Tran, Robert E Emerson, Lee Ann Baldrige, M Francesca Monn, Konstantinos Linos, Liang Cheng
AIMS: To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status. METHODS: The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2...
October 31, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27796300/parp9-and-parp14-cross-regulate-macrophage-activation-via-stat1-adp-ribosylation
#18
Hiroshi Iwata, Claudia Goettsch, Amitabh Sharma, Piero Ricchiuto, Wilson Wen Bin Goh, Arda Halu, Iwao Yamada, Hideo Yoshida, Takuya Hara, Mei Wei, Noriyuki Inoue, Daiju Fukuda, Alexander Mojcher, Peter C Mattson, Albert-László Barabási, Mark Boothby, Elena Aikawa, Sasha A Singh, Masanori Aikawa
Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate macrophage activation. In primary macrophages, PARP9 and PARP14 have opposing roles in macrophage activation. PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNγ) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells...
October 31, 2016: Nature Communications
https://www.readbyqxmd.com/read/27795451/3-deoxysappanchalcone-promotes-proliferation-of-human-hair-follicle-dermal-papilla-cells-and-hair-growth-in-c57bl-6-mice-by-modulating-wnt-%C3%AE-catenin-and-stat-signaling
#19
Young Eun Kim, Hyung Chul Choi, In-Chul Lee, Dong Yeon Yuk, Hyosung Lee, Bu Young Choi
3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle dermal papilla cells (HDPCs) and mouse hair growth in vivo. A real-time cell analyzer system, luciferase assay, Western blot and real-time polymerase chain reaction (PCR) were employed to measure the biochemical changes occurring in HDPCs in response to 3-DSC treatment. The effect of 3-DSC on hair growth in C57BL/6 mice was also examined...
November 1, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27790218/stat6-dependent-inhibition-of-mincle-expression-in-mouse-and-human-antigen-presenting-cells-by-the-th2-cytokine-il-4
#20
Thomas Hupfer, Judith Schick, Katrin Jozefowski, David Voehringer, Jenny Ostrop, Roland Lang
The C-type lectin receptors (CLRs) Mincle, Mcl, and Dectin-2 bind mycobacterial and fungal cell wall glycolipids and carbohydrates. Recently, we described that expression of these CLR is downregulated during differentiation of human monocytes to dendritic cells (DC) in the presence of GM-CSF and IL-4. Here, we demonstrate that the Th2 cytokine IL-4 specifically inhibits expression of Mincle, Mcl, and Dectin-2 in human antigen-presenting cells (APC). This inhibitory effect of IL-4 was observed across species, as murine macrophages and DC treated with IL-4 also downregulated these receptors...
2016: Frontiers in Immunology
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