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https://www.readbyqxmd.com/read/28807283/neospora-caninum-rop16-play-an-important-role-in-the-pathogenicity-by-phosphorylating-host-cell-stat3
#1
Lei Ma, Gongzhen Liu, Jing Liu, Muzi Li, Heng Zhang, Di Tang, Qun Liu
Neospora caninum is a common cause of abortions in cattle and nervous system dysfunctions in dogs. Our analysis shows that NcROP16 and TgROP16 have similar structures and may have similar functions. To our surprise, we found that similar to the T. gondii RH strain, the N. caninum Nc-1 strain could phosphorylate STAT3(Y705), but in contrast to T. gondii, N. caninum Nc-1 could not phosphorylate STAT6(Y641). We constructed a gene-knockout plasmid and screened ΔNcROP16 strains at the gene, protein and transcription levels...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28801456/correction-for-yang-et-al-cross-talk-between-histone-deacetylase-4-and-stat6-in-the-transcriptional-regulation-of-arginase-1-during-mouse-dendritic-cell-differentiation
#2
Quan Yang, Jianyang Wei, Limei Zhong, Maohua Shi, Pan Zhou, Shengkai Zuo, Kang Wu, Mingjiang Zhu, Xi Huang, Ying Yu, Hui Zhang, Huiyong Yin, Jie Zhou
No abstract text is available yet for this article.
September 1, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28774779/extensive-and-functional-overlap-of-the-stat6-and-rxr-cistromes-in-the-active-enhancer-repertoire-of-human-cd14-monocyte-derived-differentiating-macrophages
#3
REVIEW
Zsolt Czimmerer, Zsuzsanna S Nagy, Gergely Nagy, Attila Horvath, Timea Silye-Cseh, Agnes Kriston, David Jonas, Sascha Sauer, Laszlo Steiner, Bence Daniel, Jean-Francois Deleuze, Laszlo Nagy
Macrophages are able to differentiate into classically polarized (M1) or alternatively polarized (M2) states upon encountering pro-inflammatory cytokines such as interferon (IFN) γ or anti-inflammatory cytokines such as interleukin (IL) -4/IL-13, respectively. Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR). It has been also documented that cytokines are able to modulate macrophage responses to lipid signals but the nature of these interactions and the underlying mechanisms of these processes especially at the level of the chromatinized genome are not well understood...
July 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28770377/1-6-o-o-diacetylbritannilactone-inhibits-eotaxin-1-and-alox15-expression-through-inactivation-of-stat6-in-a549-cells
#4
Xi Chen, Ning Ji, Nan Qin, Sheng-An Tang, Ran Wang, Yuling Qiu, Hongquan Duan, Dexin Kong, Meihua Jin
1,6-O,O-Diacetylbritannilactone (OODBL), a plant sesquiterpene lactone, was previously reported to show multiple pharmacological effects such as anti-cancer and anti-inflammatory activities. In this study, we investigated the anti-inflammatory effect of OODBL on interleukin (IL)-4-induced signal transducer and activator of transcription 6 (STAT6) signaling pathway in human lung A549 cells. We found that OODBL dramatically inhibited IL-4-induced messenger RNA (mRNA) expression of eotaxin-1 and arachidonate 15-lipoxygenase-1 (ALOX15) in a dose-dependent manner...
August 2, 2017: Inflammation
https://www.readbyqxmd.com/read/28765368/il-4-secreting-eosinophils-promote-endometrial-stromal-cell-proliferation-and-prevent-chlamydia-induced-upper-genital-tract-damage
#5
Rodolfo D Vicetti Miguel, Nirk E Quispe Calla, Darlene Dixon, Robert A Foster, Andrea Gambotto, Stephen D Pavelko, Luanne Hall-Stoodley, Thomas L Cherpes
Genital Chlamydia trachomatis infections in women typically are asymptomatic and do not cause permanent upper genital tract (UGT) damage. Consistent with this presentation, type 2 innate and TH2 adaptive immune responses associated with dampened inflammation and tissue repair are elicited in the UGT of Chlamydia-infected women. Primary C. trachomatis infection of mice also causes no genital pathology, but unlike women, does not generate Chlamydia-specific TH2 immunity. Herein, we explored the significance of type 2 innate immunity for restricting UGT tissue damage in Chlamydia-infected mice, and in initial studies intravaginally infected wild-type, IL-10(-/-), IL-4(-/-), and IL-4Rα(-/-) mice with low-dose C...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28752100/downregulation-of-mir-214-3p-may-contribute-to-pathogenesis-of-ulcerative-colitis-via-targeting-stat6
#6
Jin-An Li, Yong-Duo Wang, Kui Wang, Zhen-Lan Wang, Dao-Yong Jia, Bi-Ying Yang, Chang-Bing Xiong
MicroRNAs (miRs) are small noncoding RNA molecules and recently have demonstrated that altered expression and functions are their tight association with ulcerative colitis (UC). Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 in the pathogenesis of UC remain to be elucidated. In this study, significant lower level of miR-214-3p and higher level of STAT6 in the intestinal mucosa of active UC patients compared with the health controls were confirmed by quantitative real-time PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28749793/pax8-expression-in-solitary-fibrous-tumor-a-potential-diagnostic-pitfall
#7
David Ullman, Jennifer Gordetsky, Gene P Siegal, Carlos N Prieto-Granada, Shi Wei, Todd M Stevens
PAX8 is used as a diagnostic aid in classifying retroperitoneal (RP) spindle cell tumors. PAX8 positivity in a spindled RP tumor is typically associated with sarcomatoid renal cell carcinoma (SRCC). However, PAX8 expression in solitary fibrous tumor (SFT), a tumor not uncommon to the RP, has not been extensively studied. We investigated the expression of PAX8 in SFTs and other spindle cell RP tumors. We collected 30 SFT, 23 SRCC, 11 gastrointestinal stromal tumors, 2 synovial sarcomas, 6 dedifferentiated liposarcomas (DDLS), 4 well differentiated liposarcomas (WDLS), and select other tumors...
July 26, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28749086/1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol-plag-reduces-hepatic-injury-in-concanavalin-a-treated-mice
#8
Young-Eun Ko, Sun Young Yoon, Sun-Yung Ly, Joo-Heon Kim, Ki-Young Sohn, Jae Wha Kim
1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG), a chemically synthesized monoacetyldiaglyceride, is one of the constituents in Sika deer antlers and has been known traditionally as having immunomodulatory effects. However, the mechanism by which PLAG controls neutrophil migration, which evokes liver injury in the hepatitis animal model, remains largely unknown. This study was designed to evaluate the immunomodulatory effects of PLAG on cytokine secretion and neutrophil migration in vivo and in vitro. The injection of mice with Concanavalin A (Con A) induced leukocyte infiltration in the liver and increased plasma cytokine levels...
July 27, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28745577/advanced-cancer-pain-the-search-for-genetic-factors-correlated-with-interindividual-variability-in-opioid-requirement
#9
Maja Matic, Joost Lm Jongen, Laure Elens, Saskia N de Wildt, Dick Tibboel, Peter Ae Sillevis Smitt, Ron Hn van Schaik
AIM: To assess association between genetic variants and opioid requirement in cancer patients. MATERIALS & METHODS: A prospective observational trial of 243 advanced cancer patients with inadequate analgesia treated by the palliative care team was analyzed for ABCB1, ARRB2, COMT, GCH1, IL1RN, KCNJ6, OPRM1, RHBDF2, SCN9A and Stat6 polymorphisms. RESULTS: For patients carrying OPRM1 118AG/GG and COMT 472GG (Val158Val) or these genotypes alone, a significant higher median percentage dose increase was observed (95...
August 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28739140/the-il-4-receptor-%C3%AE-has-a-critical-role-in-bone-marrow-derived-fibroblast-activation-and-renal-fibrosis
#10
Hua Liang, Zhengmao Zhang, Jingyin Yan, Yuguo Wang, Zhaoyong Hu, William E Mitch, Yanlin Wang
Renal fibrosis is a common pathway leading to the progression of chronic kidney disease, and bone marrow-derived fibroblasts contribute significantly to the development of renal fibrosis. However, the signaling mechanisms underlying the activation of these fibroblasts are not completely understood. Here, we examined the role of IL-4 receptor α (IL-4Rα) in the activation of myeloid fibroblasts in two experimental models of renal fibrosis. Compared with wild-type mice, IL-4Rα knockout mice accumulated fewer bone marrow-derived fibroblasts and myofibroblasts in their kidneys...
July 21, 2017: Kidney International
https://www.readbyqxmd.com/read/28731041/risk-assessment-in-solitary-fibrous-tumors-validation-and-refinement-of-a-risk-stratification-model
#11
Elizabeth G Demicco, Michael J Wagner, Robert G Maki, Vishal Gupta, Ilya Iofin, Alexander J Lazar, Wei-Lien Wang
Solitary fibrous tumors are an uncommon sarcoma type characterized by NAB2-STAT6 gene fusion. While solitary fibrous tumors metastasize in 5-25% of cases, it has historically been challenging to determine which specific tumor and patient characteristics predict aggressive behavior. We previously reported on a novel risk stratification scheme for solitary fibrous tumors incorporating patient age, tumor size, and mitotic activity to predict risk of metastasis. Herein we validate this risk stratification scheme in an independent, lower-risk population of 79 patients with primary non-meningeal solitary fibrous tumors, and propose incorporating tumor necrosis as a fourth variable to further improve the risk score...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28728219/-solitary-fibrous-tumor-hemangiopericytoma-of-central-nervous-system-a-clinicopathologic-analysis-of-71-cases
#12
X L Li, W W Fu, S Zhang, D Y Chen, Y P Chen, J Wu, X Y Liu, G P Li, S M Lin, S Luo, S S Cai, W Guo, X F Wang
Objective: As solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) share the same molecular genetics features, the 2016 WHO classification of central nervous system (CNS) tumors had created the combined term SFT/HPC and assigns three grades. This study aims to investigate the clinicopathologic characteristics, diagnosis, differential diagnosis and prognosis of CNS SFT/HPC. Methods: Seventy-one cases of CNS SFT and HPC were retrospectively reclassified and studied. Histopathological, immunohistochemical and imaging features were analyzed...
July 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28711499/inhibition-of-il-6-stat3-signaling-in-human-cancer-cells-using-evista
#13
Wei Shi, Dan Yan, Chongqiang Zhao, Miaomiao Xiao, Yina Wang, Haiyan Ma, Tianshu Liu, Hua Qin, Cuntai Zhang, Chenglong Li, Jiayuh Lin, Sheng Li, Jiagao Lv, Li Lin
Persistent activation of IL-6/STAT3 signaling pathway has been frequently detected in human cancer including breast cancer, colon cancer and multiple myeloma. IL-6/STAT3 can be a promising target for cancer prevent and treatment. However, few STAT3 inhibitors with high efficiency, specificity and safety is available for present clinical cancer therapy. Evista (Raloxifene·HCl) is known as selective estrogen receptor modulator which has been used for the prevention and treatment of osteoporosis and was approved for reducing the risk of invasive breast cancer...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28706306/ligand-induced-type-ii-interleukin-4-receptor-dimers-are-sustained-by-rapid-re-association-within-plasma-membrane-microcompartments
#14
David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K Christopher Garcia, Thomas D Müller, Jacob Piehler
The spatiotemporal organization of cytokine receptors in the plasma membrane is still debated with models ranging from ligand-independent receptor pre-dimerization to ligand-induced receptor dimerization occurring only after receptor uptake into endosomes. Here, we explore the molecular and cellular determinants governing the assembly of the type II interleukin-4 receptor, taking advantage of various agonists binding the receptor subunits with different affinities and rate constants. Quantitative kinetic studies using artificial membranes confirm that receptor dimerization is governed by the two-dimensional ligand-receptor interactions and identify a critical role of the transmembrane domain in receptor dimerization...
July 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28691428/stat-proteins-as-intracellular-regulators-of-resistance-to-myocardial-injury-in-context-of-cardiac-remodeling-and-targeting-for-therapy
#15
REVIEW
Andrzej Wincewicz, Stanislaw Sulkowski
Roles of STAT (signal transducers and activators of transcription) proteins are widely discussed in relation to other agents like IFN-γ that are involved in cardiovascular diseases. STAT3 protects cardiomyocytes during endotoxic shock and ischemia and prolongs survival of these cells by activation of antiapoptotic genes like bcl-2 and c-fos. Moreover, IL-6 dependent expression of STAT3 probably is responsible for hypertrophy of cardiomyocytes. On the contrary STAT1 mediates cell death by induction of caspase-1...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28689369/stat6-reliably-distinguishes-solitary-fibrous-tumors-from-myofibromas
#16
Molly Housley Smith, Nadim M Islam, Indraneel Bhattacharyya, Donald M Cohen, Sarah G Fitzpatrick
Solitary fibrous tumors (SFT) and myofibromas (MF) historically have belonged to the same morphologic spectrum and have been lumped together under the nonspecific umbrella term, "hemangiopericytoma" along with other pericytic/myoid tumors. While current evidence shows clear distinction between the two entities, they frequently remain in the same histopathologic differential diagnosis. This diagnostic dilemma especially is common for smaller incisional biopsies from the oral cavity. STAT6 immunohistochemistry (IHC) recently was established as a reliable method to detect solitary fibrous tumor; however, the literature is sparse regarding STAT6 reactivity in MFs...
July 8, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28687632/increased-levels-of-gab1-and-gab2-adaptor-proteins-skew-il-4-signaling-toward-m2-macrophage-driven-pulmonary-fibrosis-in-mice
#17
Xiaohong Guo, Tingting Li, Yun Xu, Xiayan Xu, Zhengyi Zhu, Yun Zhang, Jiaqi Xu, Kaihong Xu, Hongqiang Cheng, Xue Zhang, Yuehai Ke
M2-polarized macrophages, also known as alternatively activated macrophages, have long been associated with pulmonary fibrosis; however, the mechanism has not been fully defined. Gab1 and Gab2 proteins belong to the GAB family of adaptors and are integral components of the signal specificity in response to various extracellular stimuli. In this report, we found that levels of both Gab1 and Gab2 were elevated in M2-polarized macrophages isolated from bleomycin-induced fibrotic lungs. In vitro Gab1/2 deficiency in bone marrow-derived macrophages abrogated IL-4-mediated M2 polarization...
July 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28687236/sevoflurane-suppresses-microglial-m2-polarization
#18
Zengyang Pei, Shenghao Wang, Qi Li
Microglia can be polarized into the classical (M1) or alternative (M2) activation states in response to various stimuli. The M2 phenotype has its own set of receptor profiles, cytokine production, and chemokine secretion, of which arginase 1 (Arg1), chitinase 3-like 3 (Chi3l3, Ym1), and IL-10 have neuroprotective properties. Sevoflurane is one of the most commonly used volatile anesthetics in clinics. Previous studies have shown that sevoflurane promotes microglial M1 activation. However, it remains unclear whether sevoflurane regulates microglial M2 activation...
August 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28687087/a-rare-case-of-malignant-solitary-fibrous-tumor-in-prostate-with-review-of-the-literature
#19
Andrea Ronchi, Elvira La Mantia, Vincenzo Gigantino, Sisto Perdonà, Marco De Sio, Gaetano Facchini, Renato Franco, Annarosaria De Chiara
BACKGROUND: Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described in the prostate. The present case is characterized by some peculiarities if compared with previously reported cases of prostatic malignant solitary fibrous tumor. Firstly, it does not show a homogeneous morphology: part of the neoplasm (about 50%) showed the features of a conventional solitary fibrous tumor, while the remaining part showed the features of a malignant solitary fibrous tumor...
July 7, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28683839/solitary-fibrous-tumour-of-the-tongue-a-series-of-four-cases
#20
M M Dungarwalla, A W Barrett, A Gulati
BACKGROUND: Solitary fibrous tumour is a soft tissue tumour of mesenchymal origin. It was first described in the pleura and has since been reported in many anatomical locations. Thirteen cases in the tongue have hitherto been reported. A positive CD34 result has traditionally been used to confirm the diagnosis, although this is often non-specific to solitary fibrous tumour. To date, nuclear STAT6 expression has not been reported in solitary fibrous tumour of the tongue. METHOD: This paper presents a further four cases of solitary fibrous tumour of the tongue, the largest series to date...
July 7, 2017: Journal of Laryngology and Otology
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