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https://www.readbyqxmd.com/read/28938569/evaluation-of-autoantibody-signatures-in-meningioma-patients-using-human-proteome-arrays
#1
Shabarni Gupta, Shuvolina Mukherjee, Parvez Syed, Narendra Goud Pandala, Saket Choudhary, Vedita Anand Singh, Namrata Singh, Heng Zhu, Sridhar Epari, Santosh B Noronha, Aliasgar Moiyadi, Sanjeeva Srivastava
Meningiomas are one of the most common tumors of the Central nervous system (CNS). This study aims to identify the autoantibody biomarkers in meningiomas using high-density human proteome arrays (~17,000 full-length recombinant human proteins). Screening of sera from 15 unaffected healthy individuals, 10 individuals with meningioma grade I and 5 with meningioma grade II was performed. This comprehensive proteomics based investigation revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of several signalling pathways, which might play a crucial role in the manifestation of the disease...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28931396/il-4-induced-caveolin-1-containing-lipid-rafts-aggregation-contributes-to-muc5ac-synthesis-in-bronchial-epithelial-cells
#2
Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma, Hong Ye
BACKGROUND: Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors NF-κB. The intracellular Ca(2+) ([Ca(2+)]i) signal is required for activation of NF-κB. The transient receptor potential canonical 1 (TRPC1) channel has been shown to contribute for agonist-stimulated Ca(2+) influx in some types of cells. However, the relationships among IL-4, TRPC1 and mucus overproduction in bronchial epithelial cells (BECs) in asthma are poorly understood...
September 20, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28914981/fna-cytology-of-solitary-fibrous-tumors-and-the-diagnostic-value-of-stat6-immunocytochemistry
#3
Edneia Tani, Johan Wejde, Kristina Åström, Inga-Lill Wingmo, Olle Larsson, Felix Haglund
BACKGROUND: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene. Recent studies have indicated that nuclear STAT6 immunohistochemistry is a specific marker for SFTs. METHODS: The authors reviewed fine-needle aspiration (FNA) specimens from extracranial SFTs diagnosed at their institution between 1993 and 2017...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28903780/stat-6-signaling-pathway-and-not-interleukin-1-mediates-multi-walled-carbon-nanotube-induced-lung-fibrosis-in-mice-insights-from-an-adverse-outcome-pathway-framework
#4
Jake Nikota, Allyson Banville, Laura Rose Goodwin, Dongmei Wu, Andrew Williams, Carole Lynn Yauk, Håkan Wallin, Ulla Vogel, Sabina Halappanavar
BACKGROUND: The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A putative AOP has been developed describing MWCNT-induced pulmonary fibrosis; inflammation and the subsequent healing response induced by inflammatory mechanisms have been implicated in disease progression...
September 13, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28893952/il-4-il-13-signaling-inhibits-the-potential-of-early-thymic-progenitors-to-commit-to-the-t-cell-lineage
#5
Subhasis Barik, Mindy M Miller, Alexis N Cattin-Roy, Tobechukwu K Ukah, Weirong Chen, Habib Zaghouani
Early thymic progenitors (ETPs) are endowed with diverse potencies and can give rise to myeloid and lymphoid lineage progenitors. How the thymic environment guides ETP commitment and maturation toward a specific lineage remains obscure. We have previously shown that ETPs expressing the heteroreceptor (HR) comprising IL-4Rα and IL-13Rα1 give rise to myeloid cells but not T cells. In this article, we show that signaling through the HR inhibits ETP maturation to the T cell lineage but enacts commitment toward the myeloid cells...
September 11, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28892747/calcitonin-gene-related-peptide-exerts-anti-inflammatory-property-through-regulating-murine-macrophages-polarization-in-vitro
#6
Jia-Xi Duan, Yong Zhou, Ai-Yuan Zhou, Xin-Xin Guan, Tian Liu, Hui-Hui Yang, Hui Xie, Ping Chen
Acute lung injury (ALI) is a condition resulting from direct or indirect lung injury associated with high mortality and morbidity. The phenotype of macrophages in lung contributes to the pathological progress of ALI. Calcitonin gene-related peptide (CGRP) is one of the most abundant neuropeptides in lung, and attenuates lipopolysaccharide (LPS)-induced ALI in rats. However, the exact effect of CGRP on the activation of macrophages remains unknown. Here we investigate the effect of CGRP on the macrophages activation and inflammation in murine macrophages in vitro...
September 8, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28877454/a-stat6-pten-axis-links-regulatory-t-cells-with-adipose-tissue-function
#7
Stefanie Kälin, Maike Becker, Verena B Ott, Isabelle Serr, Fabian Hosp, Mohammad M H Mollah, Susanne Keipert, Daniel Lamp, Francoise Rohner-Jeanrenaud, Victoria K Flynn, Martin G Scherm, Lucas F R Nascimento, Katharina Gerlach, Vanessa Popp, Sarah Dietzen, Tobias Bopp, Purna Krishnamurthy, Mark H Kaplan, Manuel Serrano, Stephen C Woods, Philipp Tripal, Ralf Palmisano, Martin Jastroch, Matthias Blüher, Christian Wolfrum, Benno Weigmann, Anette-Gabriele Ziegler, Matthias Mann, Matthias H Tschöp, Carolin Daniel
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction...
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28875978/il4-and-il21-cooperate-to-induce-the-high-bcl6-protein-level-required-for-germinal-center-formation
#8
Stéphane Chevrier, Tobias Kratina, Dianne Emslie, David M Tarlinton, Lynn M Corcoran
Bcl6 is a transcriptional repressor and critical mediator of the germinal center reaction during a T cell dependent antibody response, where it enables somatic hypermutation of immunoglobulin genes and inhibits terminal differentiation via repression of Blimp1. It can also contribute to the development of diffuse large B cell lymphoma when expressed inappropriately. Bcl6 regulation is mediated both at the transcriptional and post-transcriptional levels, and in particular a strong signal through the B cell receptor causes rapid proteasomal degradation of Bcl6...
September 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28874416/growth-differentiation-factor-15-mediates-systemic-glucose-regulatory-action-of-t-helper-type-2-cytokines
#9
Seong Eun Lee, Seul Gi Kang, Min Jeong Choi, Saet-Byel Jung, Min Jeong Ryu, Hyo Kyun Chung, Joon Young Chang, Yong Kyung Kim, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Heung Kyu Lee, Hyon-Seung Yi, Minho Shong
Th2 cytokines, including IL-13 and IL-4, produced in adipose tissue are critical regulators of intra-adipose and systemic lipid and glucose metabolism. Furthermore, IL-13 is a potential therapy for insulin resistance in obese mouse models. Here, we examined mediators produced by adipocytes that are responsible for regulating systemic glucose homeostasis in response to Th2 cytokines. We used RNA-seq data analysis of cultured adipocytes to screen factors secreted in response to recombinant IL-13. Recombinant IL-13 induced expression of growth differentiation factor 15 (GDF15) via the Janus kinase-activated STAT6 pathway...
September 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28871603/targeting-histone-acetyltransferase-tip60-inhibits-intestinal-allergy
#10
Gui Yang, Bao-Hui Cheng, Shao-Bo Yang, Zhi-Qiang Liu, Shu-Qi Qiu, Li-Tao Yang, Rui-Di Xie, Xiao-Rui Geng, Mao-Gang Li, Lin Gao, Zhi-Gang Liu, Ping-Chang Yang
BACKGROUND: The over production of IgE plays a critical role in the pathogenesis of allergy; the mechanism is unclear. Histone acetyltransferase (HAT) activities are required in gene transcription of a large number of molecules in the immune system of the body. OBJECTIVES: This study tests a hypothesis that HAT Tat-interactive protein 60 (Tip60) plays an important role in the initiation of IgE-mediated allergy. METHODS: The effects of Tip60 on regulating IgE expression were assessed with B cells...
September 4, 2017: Allergy
https://www.readbyqxmd.com/read/28869107/molecular-characterization-of-a-series-of-solitary-fibrous-tumors-including-immunohistochemical-expression-of-stat6-and-natb2-stat6-fusion-transcripts-using-reverse-transcriptase-rt-polymerase-chain-reaction-pcr-technique-an-indian-experience
#11
Bharat Rekhi, Omshree Shetty, Parul Tripathi, Prachi Bapat, Mukta Ramadwar, Jyoti Bajpai, Ajay Puri
A solitary fibrous tumor (SFT) is characterized by a diverse clinicopathologic spectrum. Recent studies have unraveled STAT6 as a useful diagnostic immunohistochemical (IHC) marker for a SFT and NAB2-STAT6 as its specific gene fusion transcript. Thirty-three SFTs were tested for STAT6 immunostaining by polymer detection technique. STAT6 immunoexpression was further graded, based on intensity (mild, moderate and strong) and percentage of immunopositive tumor cells, ranging from 1 to 25%(1+); 26-50%(2+); 51-75%(3+) and in more than 75%(4+) tumor nuclei...
August 26, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28868275/recurrent-orbital-solitary-fibrous-tumor-in-a-12-year-old
#12
Alexander F Vu, Rao V Chundury, Alexander D Blandford, Julian D Perry
PURPOSE: To report the clinical features and pathology of orbital solitary fibrous tumors and present a case of a recurrence in a 12-year-old boy. METHODS: Case Report. RESULTS: A 12-year-old boy presented to our institution with double vision in upgaze for 6 months. Examination revealed 3 mm of left-sided proptosis, hypoglobus, and -3 impairment of supraduction. Magnetic resonance imaging of the orbits showed an avidly enhancing mass within the superolateral aspect of the orbit...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28865431/uncommon-presentation-of-a-rare-tumour-incidental-finding-in-an-asymptomatic-patient-case-report-and-comprehensive-review-of-the-literature-on-intrapericardial-solitary-fibrous-tumours
#13
Csilla Czimbalmos, Ibolya Csecs, Miklos Polos, Elektra Bartha, Nikolette Szucs, Attila Toth, Pal Maurovich-Horvat, David Becker, Zoltan Sapi, Zoltan Szabolcs, Bela Merkely, Hajnalka Vago
BACKGROUND: A solitary fibrous tumour is a rare, mainly benign spindle cell mesenchymal tumour most commonly originating from the pleura. An intrapericardial location of a solitary fibrous tumour is extremely unusual. We present a case of an asymptomatic patient with a slow-growing massive benign cardiac solitary fibrous tumour. CASE PRESENTATION: A 37-year-old asymptomatic female patient was referred to our hospital with an enlarged cardiac silhouette found on her screening chest X-ray...
September 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28819278/interleukin-4-induces-apoptosis-of-acute-myeloid-leukemia-cells-in-a-stat6-dependent-manner
#14
P Peña-Martínez, M Eriksson, R Ramakrishnan, M Chapellier, C Högberg, C Orsmark-Pietras, J Richter, A Andersson, T Fioretos, M Järås
Cytokines provide signals that regulate immature normal and acute myeloid leukemia (AML) cells in the bone marrow microenvironment. We here identify interleukin 4 (IL4) as a selective inhibitor of AML cell growth and survival in a cytokine screen using fluorescently labeled AML cells. RNA-sequencing of the AML cells revealed an IL4-induced upregulation of Stat6 target genes and enrichment of apoptosis-related gene expression signatures. Consistent with these findings, we found that IL4 stimulation of AML cells induced Stat6 phosphorylation and that disruption of Stat6 using CRISPR/Cas9-genetic engineering rendered cells partially resistant to IL4-induced apoptosis...
August 18, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28807283/neospora-caninum-rop16-play-an-important-role-in-the-pathogenicity-by-phosphorylating-host-cell-stat3
#15
Lei Ma, Gongzhen Liu, Jing Liu, Muzi Li, Heng Zhang, Di Tang, Qun Liu
Neospora caninum is a common cause of abortions in cattle and nervous system dysfunctions in dogs. Our analysis shows that NcROP16 and TgROP16 have similar structures and may have similar functions. To our surprise, we found that similar to the T. gondii RH strain, the N. caninum Nc-1 strain could phosphorylate STAT3(Y705), but in contrast to T. gondii, N. caninum Nc-1 could not phosphorylate STAT6(Y641). We constructed a gene-knockout plasmid and screened ΔNcROP16 strains at the gene, protein and transcription levels...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28801456/correction-for-yang-et-al-cross-talk-between-histone-deacetylase-4-and-stat6-in-the-transcriptional-regulation-of-arginase-1-during-mouse-dendritic-cell-differentiation
#16
Quan Yang, Jianyang Wei, Limei Zhong, Maohua Shi, Pan Zhou, Shengkai Zuo, Kang Wu, Mingjiang Zhu, Xi Huang, Ying Yu, Hui Zhang, Huiyong Yin, Jie Zhou
No abstract text is available yet for this article.
September 1, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28774779/extensive-and-functional-overlap-of-the-stat6-and-rxr-cistromes-in-the-active-enhancer-repertoire-of-human-cd14-monocyte-derived-differentiating-macrophages
#17
Zsolt Czimmerer, Zsuzsanna S Nagy, Gergely Nagy, Attila Horvath, Timea Silye-Cseh, Agnes Kriston, David Jonas, Sascha Sauer, Laszlo Steiner, Bence Daniel, Jean-Francois Deleuze, Laszlo Nagy
Macrophages are able to differentiate into classically polarized (M1) or alternatively polarized (M2) states upon encountering pro-inflammatory cytokines such as interferon (IFN) γ or anti-inflammatory cytokines such as interleukin (IL) -4/IL-13, respectively. Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR). It has been also documented that cytokines are able to modulate macrophage responses to lipid signals but the nature of these interactions and the underlying mechanisms of these processes especially at the level of the chromatinized genome are not well understood...
July 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28770377/1-6-o-o-diacetylbritannilactone-inhibits-eotaxin-1-and-alox15-expression-through-inactivation-of-stat6-in-a549-cells
#18
Xi Chen, Ning Ji, Nan Qin, Sheng-An Tang, Ran Wang, Yuling Qiu, Hongquan Duan, Dexin Kong, Meihua Jin
1,6-O,O-Diacetylbritannilactone (OODBL), a plant sesquiterpene lactone, was previously reported to show multiple pharmacological effects such as anti-cancer and anti-inflammatory activities. In this study, we investigated the anti-inflammatory effect of OODBL on interleukin (IL)-4-induced signal transducer and activator of transcription 6 (STAT6) signaling pathway in human lung A549 cells. We found that OODBL dramatically inhibited IL-4-induced messenger RNA (mRNA) expression of eotaxin-1 and arachidonate 15-lipoxygenase-1 (ALOX15) in a dose-dependent manner...
August 2, 2017: Inflammation
https://www.readbyqxmd.com/read/28765368/il-4-secreting-eosinophils-promote-endometrial-stromal-cell-proliferation-and-prevent-chlamydia-induced-upper-genital-tract-damage
#19
Rodolfo D Vicetti Miguel, Nirk E Quispe Calla, Darlene Dixon, Robert A Foster, Andrea Gambotto, Stephen D Pavelko, Luanne Hall-Stoodley, Thomas L Cherpes
Genital Chlamydia trachomatis infections in women typically are asymptomatic and do not cause permanent upper genital tract (UGT) damage. Consistent with this presentation, type 2 innate and TH2 adaptive immune responses associated with dampened inflammation and tissue repair are elicited in the UGT of Chlamydia-infected women. Primary C. trachomatis infection of mice also causes no genital pathology, but unlike women, does not generate Chlamydia-specific TH2 immunity. Herein, we explored the significance of type 2 innate immunity for restricting UGT tissue damage in Chlamydia-infected mice, and in initial studies intravaginally infected wild-type, IL-10(-/-), IL-4(-/-), and IL-4Rα(-/-) mice with low-dose C...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28752100/downregulation-of-mir-214-3p-may-contribute-to-pathogenesis-of-ulcerative-colitis-via-targeting-stat6
#20
Jin-An Li, Yong-Duo Wang, Kui Wang, Zhen-Lan Wang, Dao-Yong Jia, Bi-Ying Yang, Chang-Bing Xiong
MicroRNAs (miRs) are small noncoding RNA molecules and recently have demonstrated that altered expression and functions are their tight association with ulcerative colitis (UC). Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 in the pathogenesis of UC remain to be elucidated. In this study, significant lower level of miR-214-3p and higher level of STAT6 in the intestinal mucosa of active UC patients compared with the health controls were confirmed by quantitative real-time PCR...
2017: BioMed Research International
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