keyword
https://read.qxmd.com/read/38547408/oesophageal-fluoroscopy-when-and-why
#1
JOURNAL ARTICLE
Martina Scharitzer, Peter Pokieser, Olle Ekberg
Oesophageal fluoroscopy is a radiological procedure that uses dynamic recording of the swallowing process to evaluate morphology and function simultaneously, a characteristic not found in other clinical tests. It enables a comprehensive evaluation of the entire upper gastrointestinal tract, from the oropharynx to oesophagogastric bolus transport. The number of fluoroscopies of the oesophagus and the oropharynx has increased in recent decades, while the overall use of gastrointestinal fluoroscopic examinations has declined...
March 28, 2024: British Journal of Radiology
https://read.qxmd.com/read/38547341/igg4-related-disease-complicated-with-diffuse-and-chronic-gastrointestinal-inflammation-leading-to-small-intestinal-perforation
#2
JOURNAL ARTICLE
Kazuma Ino, Yoshiyuki Arinuma, Masashi Akiya, Sabine Kajita, Sosei Okina, Junichi Sakamoto, Tomoki Tanaka, Yu Matsueda, Tatsuhiko Wada, Sumiaki Tanaka, Kenji Oku, Kunihiro Yamaoka
Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a systemic inflammatory disease characterized by elevated serum IgG4, IgG4+ cell infiltration, storiform fibrosis, and obliterative phlebitis. While IgG4-RD can affect various organs, gastrointestinal tract involvement is less common. Here, we report a 70-year-old female with IgG4-RD complicated with diffuse and chronic gastrointestinal inflammation which led to small intestinal perforation. She had been suffering from anorexia, abdominal pain, vomiting, and diarrhea, and hospitalized due to recurrent ileus...
March 28, 2024: Modern rheumatology case reports
https://read.qxmd.com/read/38546826/histogram-analysis-of-mr-quantitative-parameters-are-they-correlated-with-prognostic-factors-in-prostate-cancer
#3
JOURNAL ARTICLE
Yanling Chen, Tiebao Meng, Wenxin Cao, Weijing Zhang, Jian Ling, Zhihua Wen, Long Qian, Yan Guo, Jinhua Lin, Huanjun Wang
PURPOSE: To investigate the correlation between quantitative MR parameters and prognostic factors in prostate cancer (PCa). METHOD: A total of 186 patients with pathologically confirmed PCa who underwent preoperative multiparametric MRI (mpMRI), including synthetic MRI (SyMRI), were enrolled from two medical centers. The histogram metrics of SyMRI [T1, T2, proton density (PD)] and apparent diffusion coefficient (ADC) values were extracted. The Mann‒Whitney U test or Student's t test was employed to determine the association between these histogram features and the prognostically relevant factors...
March 28, 2024: Abdominal Radiology
https://read.qxmd.com/read/38546825/diagnostic-value-of-dual-time-point-68-ga-psma-pet-ct-image-for-benign-and-malignant-lesions-in-patients-with-prostate-cancer
#4
JOURNAL ARTICLE
Liu Xiao, Minggang Su, Yuhao Li
OBJECTIVE: This study aimed to ascertain the diagnostic efficacy of routine 68 Ga-PSMA imaging conducted 1 h post-injection, in conjunction with delayed imaging performed 3 h post-injection, for differentiating between benign and malignant lesions in prostate cancer (PCa) patients. METHODS: A retrospective assessment was undertaken on 44 prostate cancer patients who had undergone both routine and delayed 68 Ga-PSMA PET/CT scans. Variations in SUVmax and SUVmean values in normal organs, primary prostate cancer sites, metastatic sites, and benign lesions were analyzed...
March 28, 2024: Abdominal Radiology
https://read.qxmd.com/read/38546788/publication-bias-in-upper-gastrointestinal-oncology-clinical-trials
#5
JOURNAL ARTICLE
Trenton Lippert, Erin Schmucker, Anchal Shukla, Ruha Reddy, Pooja Neerumalla, Gabriella Blanco, Vic Velanovich
PURPOSE: Evidence-based medicine requires evaluation of the medical literature to guide clinical reasoning and treatment recommendations. The presence of publication bias towards exclusion of non-statistically significant clinical trials may be leading to an incomplete evaluation of the literature and cause potentially incomplete guidance for patients. We aimed to compare publication rates and impact of publications of positive and negative outcome clinical trials. METHODS: We queried the US National Library of Medicine Clinical Trials database identifying clinical trials with reported results on the topics of pancreatic, liver, and gastric cancer...
March 28, 2024: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/38546414/eosinophil-associated-diseases-the-allergist-s-and-clinical-immunologist-s-perspective
#6
REVIEW
A M Marra, C M Rossi, M A Piga, G Moroncini, M B Bilò
Eosinophil-associated diseases (EADs) refer to heterogeneous conditions in which eosinophils are believed to play critical pathological roles. They encompass common respiratory conditions, such as asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), less common primary eosinophilic disorders of gastrointestinal tract, and rare conditions including eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES). A literature search was carried out in January 2024 in the MEDLINE and Scopus databases using the PubMed search engine (PubMed, National Library of Medicine, Bethesda, MD)...
March 28, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38545505/abelacimab-a-leap-forward-in-anticoagulation-with-fxi-and-fxia-inhibition
#7
REVIEW
Hisham A Badreldin, Nada Alsuhebany, Mohammed Alzahrani, Abdulmajeed M Alshehri, Maha Aldoughaim, Saleh Alqifari, Omar Yassin, Lama Alfehaid, Tariq Alqahtani
Direct Oral Anticoagulants (DOACs) have revolutionized the treatment of thromboembolic disorders, offering targeted, effective, and safer alternatives to traditional anticoagulants like heparins and vitamin K antagonists (VKAs). Despite their benefits, DOACs have drawbacks, including an increased risk of gastrointestinal bleeding and unsuitability for patients with mechanical heart valves. Recent research has highlighted Factor XI (FXI) as a promising anticoagulation target due to its significant role in pathological thrombosis and minor involvement in normal hemostasis...
2024: Curr Res Pharmacol Drug Discov
https://read.qxmd.com/read/38545046/diagnostic-advantages-of-transrectal-ultrasound-with-gastrointestinal-agent-instillation-for-rectal-adenoma-and-early-stage-rectal-cancer-comparison-of-conventional-transrectal-ultrasound-techniques
#8
JOURNAL ARTICLE
Xiang Li, Kun Huang, Yanjun Liu, Zhen Zhang, Donglin Bian
BACKGROUND: Despite being a major focus of medical research for decades, rectal cancer remains a major threat to human health. This study aimed to compare and analyze the diagnostic value of transrectal ultrasonography (TRUS) for rectal adenoma and early-stage rectal cancer before and after gastrointestinal agent instillation. METHODS: In this prospective study, patients diagnosed with rectal adenomas and early-stage rectal cancer by ultrasound were randomly selected for inclusion...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38544645/a-case-of-esophageal-adenocarcinoma-metastatic-to-the-breast
#9
Prashanth Kotla, Suimin Qiu, Jing He
Metastatic carcinoma infiltrating the breast from extramammary malignancies is an infrequent occurrence. Extramammary carcinomas that may be metastatic to the breast include gastrointestinal cancers, ovarian cancer, and lung cancer, among others. These metastatic lesions often pose a diagnostic challenge, resembling primary breast cancer in both clinical and radiographic presentations. The incidence of esophageal cancer metastasizing to the breast is low. Esophageal cancer more commonly spreads to locoregional lymph nodes, lungs, liver, and bone...
February 2024: Curēus
https://read.qxmd.com/read/38542802/gastrointestinal-microbiota-symptoms-of-depression-and-anxiety-in-anorexia-nervosa-a-re-analysis-of-the-microbian-longitudinal-study
#10
JOURNAL ARTICLE
Jasmin Ketel, Miquel Bosch-Bruguera, Greta Auchter, Ulrich Cuntz, Stephan Zipfel, Paul Enck, Isabelle Mack
The microbiota-gut-brain axis may play a role in the pathophysiology of anorexia nervosa (AN). Here, the relationship between the gastrointestinal microbiota and symptoms of depression, anxiety, and eating disorder pathology in patients with AN before ( n = 55) and after weight restoration ( n = 44) was investigated by reanalyzing the data of the MICROBIAN study. The gastrointestinal microbiota was analyzed using 16S rRNA amplicon sequencing. Symptoms of anxiety disorder, depression, and the severity of the eating disorder were measured by validated questionnaires...
March 19, 2024: Nutrients
https://read.qxmd.com/read/38541878/scoring-abdominal-symptoms-in-people-with-cystic-fibrosis
#11
REVIEW
Harold Tabori, Anton Barucha, Carlos Zagoya, Franziska Duckstein, Gabor A Dunay, Pauline Sadrieh, Louise Polte, Jochen G Mainz
(1) Background: The introduction of highly effective CFTR-modulating therapies (HEMT) has changed the course of the disease for many people with Cystic Fibrosis (pwCF). Attention previously focused on life-threatening conditions of the respiratory system has broadened, bringing the involvement of the digestive system into the clinical and scientific focus. This emphasized the need for sensitive tools to capture and quantify changes in abdominal symptoms (AS), ideally applying patient-reported outcome measures (PROMs)...
March 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38538476/proximal-gastric-cancer-time-for-organ-sparing-approach
#12
JOURNAL ARTICLE
Karol Rawicz-Pruszyński, Yutaka Endo, Diamantis Tsilimigras, Muhammad Musaab Munir, Erryk Katayama, Katarzyna Sędłak, Zuzanna Pelc, Timothy M Pawlik
BACKGROUND: A steady increase in gastroesophageal junction and proximal gastric cancer (GC) incidence has been observed in the West. Given recent advances in neoadjuvant chemotherapy (NAC), we sought to characterize short- and long-term outcomes of patients with proximal GC who underwent total (TG) vs proximal gastrectomy (PG). METHODS: Patients with stage II/III proximal GC who underwent curative-intent treatment between 2009 and 2019 were identified using National Cancer Database...
March 12, 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38538088/online-tools-to-predict-individualised-survival-for-primary-oesophageal-cancer-patients-with-and-without-pathological-complete-response-after-neoadjuvant-therapy-followed-by-oesophagectomy-development-and-external-validation-of-two-independent-nomograms
#13
JOURNAL ARTICLE
Yuqin Cao, Binhao Huang, Han Tang, Dong Dong, Tianzheng Shen, Xiang Chen, Xijia Feng, Jiahao Zhang, Liqiang Shi, Chengqiang Li, Heng Jiao, Lijie Tan, Jie Zhang, Hecheng Li, Yajie Zhang
OBJECTIVE: This study aimed to develop and validate robust predictive models for patients with oesophageal cancer who achieved a pathological complete response (pCR) and those who did not (non-pCR) after neoadjuvant therapy and oesophagectomy. DESIGN: Clinicopathological data of 6517 primary oesophageal cancer patients who underwent neoadjuvant therapy and oesophagectomy were obtained from the National Cancer Database for the training cohort. An independent cohort of 444 Chinese patients served as the validation set...
March 27, 2024: BMJ Open Gastroenterology
https://read.qxmd.com/read/38538073/laboratory-investigation-of-peritoneal-fluids-an-updated-practical-approach-based-on-the-available-evidence
#14
JOURNAL ARTICLE
Giulia Colombo, Elena Aloisio, Mauro Panteghini
Even though analysis of peritoneal fluids (PF) is often requested to medical laboratories for biochemical and morphological tests, there is still no mutual agreement on what the most appropriate way is to manage PF samples and which tests should be appropriately executed. In this update, we tried to identify the most useful tests for PF analysis to establish best practice indications. We performed a literature review and examined available guidelines to select the most appropriate tests by an evidence-based approach...
March 27, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38538071/enteroblastic-gastric-cancer-subtype-holds-therapeutic-clues
#15
EDITORIAL
Vikram Deshpande, Munita Bal
No abstract text is available yet for this article.
March 27, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38536603/a-case-of-young-male-with-recurrent-acute-pancreatitis-caused-by-an-intrapancreatic-gastric-duplication-cyst
#16
JOURNAL ARTICLE
Sayaka Miyamoto, Yasutaka Ishii, Masahiro Serikawa, Yumiko Tatsukawa, Shinya Nakamura, Juri Ikemoto, Yosuke Tamura, Kenichiro Uemura, Koji Arihiro, Shiro Oka
Gastric duplication cyst (GDC) is a rare gastrointestinal malformation that frequently occurs in the greater curvature of the gastric antrum or corpus. Herein, we reported a case of intrapancreatic GDC found as a result of recurring pancreatitis. A 15-year-old man experienced repeated episodes of acute pancreatitis and was found to have a cystic lesion in the pancreatic tail. Contrast-enhanced computed tomography revealed a 20-mm cystic lesion with an enhanced thick wall. Endoscopic ultrasonography revealed an anechoic cyst with a three-layered wall...
March 27, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38534341/gut-brain-interactions-and-their-impact-on-astrocytes-in-the-context-of-multiple-sclerosis-and-beyond
#17
REVIEW
Julia Zißler, Veit Rothhammer, Mathias Linnerbauer
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to physical and cognitive impairment in young adults. The increasing prevalence of MS underscores the critical need for innovative therapeutic approaches. Recent advances in neuroimmunology have highlighted the significant role of the gut microbiome in MS pathology, unveiling distinct alterations in patients' gut microbiota. Dysbiosis not only impacts gut-intrinsic processes but also influences the production of bacterial metabolites and hormones, which can regulate processes in remote tissues, such as the CNS...
March 13, 2024: Cells
https://read.qxmd.com/read/38533927/altered-glycosylation-in-secreting-cells-of-the-gastric-glands-of-aquaporin-4-deficient-mice
#18
JOURNAL ARTICLE
Donatella Mentino, Grazia Paola Nicchia, Antonio Frigeri, Salvatore Desantis, Marco Vito Guglielmi, Daniela Semeraro, Giovanni Scillitani, Maria Mastrodonato
Aquaporins (AQPs) are important for water transport in the gastrointestinal tract. Changes in their expression and/or localization could cause in disorders and be used as therapeutic targets. Aquaporin-4 (AQP4) is expressed predominantly on the basolateral membrane of the parietal cells in the corpus of the murine gastric glands. Although the secretion of gastric juice is not affected in AQP4-deficient knockout, we evaluated by light microscopy whether the lack of AQP4 affects the glycopatterns of secreting gastric cells...
March 27, 2024: Microscopy Research and Technique
https://read.qxmd.com/read/38533568/-astragalus-membranaceus-polysaccharide-regulates-small-intestinal-microbes-and-activates-il-22-signal-pathway-to-promote-intestinal-stem-cell-regeneration-in-aging-mice
#19
JOURNAL ARTICLE
Jia-Ting Yin, Ming-Ruo Zhang, Shu Zhang, Shu-Hui Yang, Jian-Ping Li, Yun Liu, Jin-Ao Duan, Jian-Ming Guo
Aging can cause degenerative changes in multiple tissues and organs. Gastrointestinal diseases and dysfunctions are common in the elderly population. In this study, we investigated the effects of Astragalus membranaceus polysaccharide (APS) and Astragalus membranaceus ethanol extract (AEE) on age-related intestinal dysfunction and gut microbiota dysbiosis in naturally aging mice. The energy expenditure and physical activity of 23-month-old C57BL6/J mice were recorded using a metabolic cage system. Pathological changes in the intestine were evaluated using Alcian blue staining...
March 26, 2024: American Journal of Chinese Medicine
https://read.qxmd.com/read/38533436/a-large-gastric-splenosis-mimicking-gastrointestinal-stromal-tumor-a-case-report-and-literature-review
#20
Xiaotian Li, Xianwen Hu, Pan Wang, Guiyun Hu, Bin Zhou, Jiong Cai
Splenosis pertains to the phenomenon wherein a segment of the spleen undergoes detachment and becomes embedded in other anatomical regions subsequent to traumatic rupture or therapeutic resection, and then progressively establishing blood circulation to foster the regeneration of splenic tissue. Existing literature posits that splenosis predominantly manifests within the confines of the abdominal and pelvic cavities. The objective of the current study was to present an uncommon case involving the occurrence of splenosis within the gastric myometrium, thereby contributing to the current knowledge regarding splenosis...
May 2024: Experimental and Therapeutic Medicine
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