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Neonatal encephalopathy

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https://www.readbyqxmd.com/read/29907863/attenuation-of-retinal-vascular-development-in-neonatal-mice-subjected-to-hypoxic-ischemic-encephalopathy
#1
Ismail S Zaitoun, Ulas Cikla, Dila Zafer, Eshwar Udho, Reem Almomani, Andrew Suscha, Pelin Cengiz, Christine M Sorenson, Nader Sheibani
A significant proportion of children that survive hypoxic-ischemic encephalopathy (HIE) develop visual impairment. These visual deficits are generally attributed to injuries that occur in the primary visual cortex and other visual processing systems. Recent studies suggested that neuronal damage might also occur in the retina. An important structure affecting the viability of retinal neurons is the vasculature. However, the effects of HIE on the retinal neurovasculature have not been systemically evaluated...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907848/cerebral-blood-flow-and-serum-neuron-specific-enolase-in-early-onset-neonatal-sepsis
#2
Mohammed S El Shimy, Nehal M El-Raggal, Rania A El-Farrash, Hebatallah A Shaaban, Hanan E Mohamed, Noha M Barakat, Ahmed S Farag, Abeer K El Zohiery, Menat Allah A Shaaban, Dina H Salama
BACKGROUND AND OBJECTIVES: Sepsis leads to systemic inflammatory response with cerebral blood flow (CBF) alteration and blood-brain barrier disruption that contribute to sepsis-associated encephalopathy (SAE). We aimed to evaluate cord blood neuron-specific enolase (cNSE) and CBF in early-onset neonatal sepsis (EONS) as predictors of SAE and to define short-term neurodevelopmental outcomes among survivors. METHODS: cNSE was measured in 200 neonates with antenatal risk factors for EONS, stratified into two groups: sepsis (n = 96) and no-sepsis (n = 104)...
May 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29906699/causes-of-mortality-in-early-infantile-epileptic-encephalopathy-a-systematic-review
#3
REVIEW
Graciane Radaelli, Francisco de Souza Santos, Wyllians Vendramini Borelli, Leonardo Pisani, Magda Lahorgue Nunes, Fulvio Alexandre Scorza, Jaderson Costa da Costa
INTRODUCTION: Early infantile epileptic encephalopathy syndrome (EIEE), also known as Ohtahara syndrome, is an age-dependent epileptic encephalopathy syndrome defined by clinical features and electroencephalographic findings. Epileptic disorders with refractory seizures beginning in the neonatal period and/or early infancy have a potential risk of premature mortality, including sudden death. We aimed to identify the causes of death in EIEE and conducted a literature survey of fatal outcomes...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29905558/urinary-malondialdehyde-as-a-predictive-and-diagnostic-marker-for-neonatal-acute-kidney-injury
#4
Y Hodovanets, A Babintseva, L Agafonova, O Makarova, A Frunza
Newborns are especially prone to oxidative stress (OS). Many free radical-mediated diseases have been described in newborns including bronchopulmonary dysplasia, respiratory distress syndrome, encephalopathy, and kidney injury. Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns. 67 critically sick full-term neonates were enrolled in the study including 31 newborns with AKI (group I) and 36 newborns without AKI (group II)...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29895836/predictive-value-of-early-eeg-for-seizures-in-neonates-with-hypoxic-ischemic-encephalopathy-undergoing-therapeutic-hypothermia
#5
Marie-Coralie Cornet, Archana Pasupuleti, Annie Fang, Fernando Gonzalez, Thomas Shimotake, Donna Marie Ferriero, Hannah Cranley Glass, Maria Roberta Cilio
OBJECTIVES: To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. METHODS: We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming...
May 3, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29893939/experience-of-perinatal-and-neonatal-chikungunya-virus-chikv-infection-in-a-tertiary-care-neonatal-centre-during-outbreak-in-north-india-in-2016-a-case-series
#6
Surender Kumar, Gopal Agrawal, Sanjay Wazir, Anil Kumar, Sandeep Dubey, Manish Balde, Bir Singh Yadav
Background: In 2016, there was a massive outbreak of chikungunya in North India. During the epidemic, we observed many neonatal and early infantile cases of chikungunya, with a probable perinatal transmission. Methods: This retrospective study was carried out in a tertiary care neonatal centre between August 2016 and November 2016. Chikungunya virus (CHIKV) infection was detected and confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and/or serology (anti-CHIKV IgM) in mothers and infants...
June 9, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29893645/changes-in-brain-metabolite-concentrations-after-neonatal-hypoxic-ischemic-encephalopathy
#7
Jun Shibasaki, Noriko Aida, Naho Morisaki, Moyoko Tomiyasu, Yuri Nishi, Katsuaki Toyoshima
Purpose To investigate the time-course changes and predictive utility of brain metabolite concentrations in neonatal hypoxic-ischemic encephalopathy (HIE). Materials and Methods Sixty-eight neonates (age, 35-41 gestational weeks) with HIE were admitted to a neonatal intensive care unit between September 2009 and March 2016 and examined by using proton MR spectroscopy at 18-96 hours (n = 25) and 7-14 days (n = 64) after birth (35-43 postmenstrual weeks) to estimate metabolite concentrations in the deep gray matter...
June 12, 2018: Radiology
https://www.readbyqxmd.com/read/29892033/extreme-neonatal-hyperbilirubinemia-acute-bilirubin-encephalopathy-and-kernicterus-spectrum-disorder-in-children-with-galactosemia
#8
Laura F Bech, Mette Line Donneborg, Allan M Lund, Finn Ebbesen
BACKGROUND: Galactosemia has not been recognized as a cause of extreme neonatal hyperbilirubinemia, although growing evidence supports this association. METHODS: In a retrospective cohort study, we identified children with galactosemia due to GALT deficiency using the Danish Metabolic Laboratory Database. Among these, we identified children with extreme neonatal hyperbilirubinemia or symptoms of ABE. Extreme neonatal hyperbilirubinemia was defined as maximum total serum bilirubin (TSBmax) ) level ≥450 µmol/L and a ratio of conjugated serum bilirubin/TSB <0...
May 31, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29889725/introduction-of-continuous-video-eeg-monitoring-into-2-different-nicu-models-by-training-neonatal-nurses
#9
Ipsita Goswami, Luis Bello-Espinosa, Jeffrey Buchhalter, Harish Amin, Alexandra Howlett, Michael Esser, Sumesh Thomas, Cathy Metcalfe, Jan Lind, Norma Oliver, Silvia Kozlik, Khorshid Mohammad
BACKGROUND: Continuous video electroencephalographic (EEG) (cvEEG) monitoring is emerging as the standard of care for diagnosis and management of neonatal seizures. However, cvEEG is labor-intensive and the need to initiate and interpret studies on a 24-hour basis is a major limitation. PURPOSE: This study aims at establishing consistency in monitoring of newborns admitted to 2 different neonatal intensive care units (NICUs) managed by the same neurocritical care team...
June 8, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29888094/predicting-neonatal-encephalopathy-from-maternal-data-in-electronic-medical-records
#10
Thomas Li, Cheng Gao, Chao Yan, Sarah Osmundson, Bradley A Malin, You Chen
Neonatal encephalopathy (NE) is a leading cause of neonatal mortality and lifetime neurological disability. The earlier the risk of NE can be assessed, the more effective interventions can be in preventing adverse outcomes. Existing studies that focus on intrapartum risk factors do not provide the early prognostic forecasting necessary to prepare healthcare professionals to intervene early in a high-risk NE case. This work used maternal data in a supervised machine learning framework to predict NE events. Specifically, we 1) collected the electronic medical records (EMRs) for 104 NE newborns and 31,054 non-NE newborns and their mothers, 2) trained and tested a regularized logistic regression on imbalanced and high-dimensional EMR data, and 3) discerned important features that could be possible risk factors...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29887039/xenon-combined-with-hypothermia-in-perinatal-hypoxic-ischemic-encephalopathy-a-noble-gas-a-noble-mission
#11
REVIEW
Ashraf R Amer, Dorothy E Oorschot
Perinatal hypoxia-ischemia is a major cause of neonatal morbidity. It generates primary neuronal damage of the neonatal brain and later secondary damage when reperfusion of the ischemic brain tissue causes a surge of oxygen free radicals and inflammation. This post-hypoxic-ischemic brain damage is a leading cause of motor and intellectual disabilities in survivors. Research worldwide has focused on mitigating this injury. Mild or moderate hypothermia is the standard treatment in many centers. However, its benefit is modest and the search for combinatorial effective neuroprotectants continues...
February 27, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29886041/outcomes-after-acute-symptomatic-seizures-in-children-admitted-to-a-neonatal-neurocritical-care-service
#12
Hannah C Glass, Adam L Numis, Dawn Gano, Varun Bali, Elizabeth E Rogers
BACKGROUND: Neonatal seizures due to acute brain injury are associated with high rates of death, disability, and epilepsy. Our objective was to examine incidence of and risk factors for epilepsy among survivors of acute symptomatic neonatal seizures who were cared for by a neonatal neurocritical care service. METHODS: Neonates with acute symptomatic seizures who were admitted to UCSF Benioff Children's Hospital Neuro-Intensive Care Nursery from July 2008 to June 2014 were considered for inclusion...
April 20, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29880417/acute-neonatal-bilirubin-encephalopathy-in-the-state-of-utah-2009-2018
#13
Robert D Christensen, Archana M Agarwal, Tracy I George, Vinod K Bhutani, Hassan M Yaish
Herein we report a case series of seven newborn infants, all apparently well at birth, who in the period since 2009 were cared for in the State of Utah with acute bilirubin encephalopathy (ABE). This report summarizes our attempts to define common features of these seven through a state-wide voluntary registry, as a step toward devising new means of preventing such cases in the future. In previous reports of ABE, many of the affected neonates had no clearly defined explanation for their progressive hyperbilirubinemia...
May 23, 2018: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29875342/anti-cytokine-therapy-to-attenuate-ischemic-reperfusion-associated-brain-injury-in-the-perinatal-period
#14
REVIEW
Clémence Disdier, Xiaodi Chen, Jeong-Eun Kim, Steven W Threlkeld, Barbara S Stonestreet
Perinatal brain injury is a major cause of morbidity and long-standing disability in newborns. Hypothermia is the only therapy approved to attenuate brain injury in the newborn. However, this treatment is unfortunately only partially neuroprotective and can only be used to treat hypoxic-ischemic encephalopathy in full term infants. Therefore, there is an urgent need for adjunctive therapeutic strategies. Post-ischemic neuro-inflammation is a crucial contributor to the evolution of brain injury in neonates and constitutes a promising therapeutic target...
June 7, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29873135/neonatal-encephalopathy-how-can-we-improve-clinical-outcomes
#15
Malcolm Battin, Lynn Sadler
No abstract text is available yet for this article.
June 6, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29868521/measuring-near-infrared-spectroscopy-derived-cerebral-autoregulation-in-neonates-from-research-tool-toward-bedside-multimodal-monitoring
#16
REVIEW
Liesbeth Thewissen, Alexander Caicedo, Petra Lemmers, Frank Van Bel, Sabine Van Huffel, Gunnar Naulaers
Introduction: Cerebral autoregulation (CAR), the ability of the human body to maintain cerebral blood flow (CBF) in a wide range of perfusion pressures, can be calculated by describing the relation between arterial blood pressure (ABP) and cerebral oxygen saturation measured by near-infrared spectroscopy (NIRS). In literature, disturbed CAR is described in different patient groups, using multiple measurement techniques and mathematical models. Furthermore, it is unclear to what extent cerebral pathology and outcome can be explained by impaired CAR...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29867720/early-detection-of-hypothermic-neuroprotection-using-t2-weighted-magnetic-resonance-imaging-in-a-mouse-model-of-hypoxic-ischemic-encephalopathy
#17
Sydney E Doman, Akanksha Girish, Christina L Nemeth, Gabrielle T Drummond, Patrice Carr, Maxine S Garcia, Michael V Johnston, Sujatha Kannan, Ali Fatemi, Jiangyang Zhang, Mary Ann Wilson
Perinatal hypoxic-ischemic encephalopathy (HIE) can lead to neurodevelopmental disorders, including cerebral palsy. Standard care for neonatal HIE includes therapeutic hypothermia, which provides partial neuroprotection; magnetic resonance imaging (MRI) is often used to assess injury and predict outcome after HIE. Immature rodent models of HIE are used to evaluate mechanisms of injury and to examine the efficacy and mechanisms of neuroprotective interventions such as hypothermia. In this study, we first confirmed that, in the CD1 mouse model of perinatal HIE used for our research, MRI obtained 3 h after hypoxic ischemia (HI) could reliably assess initial brain injury and predict histopathological outcome...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29867713/cerebral-lactate-concentration-in-neonatal-hypoxic-ischemic-encephalopathy-in-relation-to-time-characteristic-of-injury-and-serum-lactate-concentration
#18
Tai-Wei Wu, Benita Tamrazi, Kai-Hsiang Hsu, Eugenia Ho, Aaron J Reitman, Matthew Borzage, Stefan Blüml, Jessica L Wisnowski
Background: Cerebral lactate concentration can remain detectable in neonatal hypoxic-ischemic encephalopathy (HIE) after hemodynamic stability. The temporal resolution of regional cerebral lactate concentration in relation to the severity or area of injury is unclear. Furthermore, the interplay between serum and cerebral lactate in neonatal HIE has not been well defined. The study aims to describe cerebral lactate concentration in neonatal HIE in relation to time, injury, and serum lactate...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29866591/renal-saturation-and-acute-kidney-injury-in-neonates-with-hypoxic-ischemic-encephalopathy-undergoing-therapeutic-hypothermia
#19
Valerie Y Chock, Adam Frymoyer, Christine G Yeh, Krisa P Van Meurs
OBJECTIVE: To investigate the range of renal near-infrared spectroscopy (NIRS) measures in neonates undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy (HIE) and to determine the association between renal NIRS measures and the development of acute kidney injury (AKI). STUDY DESIGN: A retrospective chart review was conducted of neonates with moderate to severe HIE who received therapeutic hypothermia at a tertiary care center from 2014 to 2016...
June 1, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29863263/study-on-the-correlation-of-changes-of-igf-1-gh-and-ngb-levels-and-nbna-score-in-neonates-with-hypoxic-ischemic-encephalopathy
#20
G Liu, H-W Wu, Z-G Li
OBJECTIVE: The aim of this work was to investigate the correlation between dynamic changes of serum insulin-like growth factor 1 (IGF-1), growth hormone (GH), neuroglobin (NGB), and neonatal behavioral neurological assessment (NBNA) scores in different periods in neonates with hypoxic ischemic encephalopathy (HIE). PATIENTS AND METHODS: Sixty HIE patients in the Neonatal Department of our hospital were selected. They were divided into the mild group (35 cases), moderate group (19 cases), and severe group (six cases) according to the diagnostic criteria...
May 2018: European Review for Medical and Pharmacological Sciences
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