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https://www.readbyqxmd.com/read/29045899/early-transcriptional-divergence-marks-virus-specific-primary-human-cd8-t-cells-in-chronic-versus-acute-infection
#1
David Wolski, Peter K Foote, Diana Y Chen, Lia L Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T Waring, Damien C Tully, Todd M Allen, Raymond T Chung, Jörg Timm, W Nicholas Haining, Arthur Y Kim, Thomas F Baumert, Georg M Lauer
Distinct molecular pathways govern the differentiation of CD8(+) effector T cells into memory or exhausted T cells during acute and chronic viral infection, but these are not well studied in humans. Here, we employed an integrative systems immunology approach to identify transcriptional commonalities and differences between virus-specific CD8(+) T cells from patients with persistent and spontaneously resolving hepatitis C virus (HCV) infection during the acute phase. We observed dysregulation of metabolic processes during early persistent infection that was linked to changes in expression of genes related to nucleosomal regulation of transcription, T cell differentiation, and the inflammatory response and correlated with subject age, sex, and the presence of HCV-specific CD4(+) T cell populations...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29037928/melanoma-of-the-foot-is-associated-with-advanced-disease-and-poorer-survival
#2
Barbara E Adams, Peter D Peng, Mitzi L Williams
The purpose of the present study was to review the outcomes and assess the prognostic factors associated with foot melanoma. We hypothesized that primary melanoma of the foot would be more likely to present at an advanced stage and be associated with poorer outcomes. Both univariate and multivariate analyses were conducted to examine the relationships between patients' demographic, clinical, and pathologic characteristics and deaths within 5 years. Categorical data were summarized as frequencies and percentages and continuous variables as mean ± standard deviation...
October 13, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29032706/quality-and-predictors-of-diabetes-care-among-patients-with-schizophrenia-a-danish-nationwide-study
#3
Mette Jørgensen, Jan Mainz, Fabrizio Carinci, Reimar W Thomsen, Søren Paaske Johnsen
OBJECTIVE: Patients with schizophrenia have a high prevalence of diabetes, but data on diabetes care quality for these patients are limited. This nationwide study compared the quality of diabetes care among individuals with and without schizophrenia and identified predictors of care quality. METHODS: In a population-based cohort study, 83,813 individuals with diabetes seen at hospital outpatient clinics between 2005 and 2013, including 669 with comorbid schizophrenia, were identified from Danish registries...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28988348/insight-into-the-neuroendocrine-basis-of-signal-evolution-a-case-study-in-foot-flagging-frogs
#4
REVIEW
Lisa A Mangiamele, Matthew J Fuxjager
A hallmark of sexual selection is the evolution of elaborate male sexual signals. Yet, how the physiology of an animal changes to support a new or modified signal is a question that has remained largely unanswered. Androgens are important in regulating male reproductive behavior, therefore, selection for particular signals may drive the evolution of increased androgenic sensitivity in the neuro-motor systems underlying their production. Studies of the neuroendocrine mechanisms of anuran sexual signaling provide evidence to support this idea...
October 7, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28984811/dizziness-handicap-inventory-score-is-highly-correlated-with-markers-of-gait-disturbance
#5
Damiano Zanotto, Erin M Mamuyac, Adam R Chambers, John S Nemer, John A Stafford, Sunil K Agrawal, Anil K Lalwani
OBJECTIVE: To evaluate the association between Dizziness Handicap Inventory-Screening version (DHI-S) score and spatiotemporal gait parameters using SoleSound, a newly developed, inexpensive, portable footwear-based gait analysis system. STUDY DESIGN: Cross-sectional. PATIENTS: One hundred eighteen patients recruited from otology clinic. INTERVENTION(S): Subjects completed the DHI-S survey and four uninterrupted walking laps wearing SoleSound instrumented footwear on a hard, flat surface for 100 m...
October 4, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28979615/-podiatric-risk-screening-in-patients-with-type-2-diabetes-in-antananarivo
#6
Sitraka Angelo Raharinavalona, Haritsiky Robertini Ramalanjaona, Nalisoa Andrianera, Andrinirina Dave Patrick Rakotomalala, George Ramahandridona
Diabetic foot disease heavily weighs upon diabetics, being a significant cause of morbidity and severe disability. Their prevention is indispensable. Our study aimed to reduce the rate of amputations in diabetics. We conducted a retrospective, descriptive, cross-sectional, multicenter study of podiatric risk screening in patients with type 2 diabetes in the Endocrinology Department at the University Hospital of Befelatanana and at the Amadia Clinic, Faravohitra, over a period of 6 months. The average age of our patients was 54...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28978462/sex-specific-kinetic-and-kinematic-indicators-of-medial-tibiofemoral-force-during-walking-and-running
#7
Jean-Francois Esculier, Richard W Willy, Michael W Baggaley, Stacey A Meardon, John D Willson
BACKGROUND: Our aims were to (1) Evaluate sex-specific contributions of peak knee flexion moment (pKFM) and peak knee adduction moment (pKAM) in medial tibiofemoral joint (TFJ) force during walking and running; (2) identify kinematic variables to estimate peak medial TFJ force. METHODS: Eighty-seven runners participated (36 females, 51 males; age=23.0±3.8years (1 standard deviation)). Kinematics and kinetics data were collected during treadmill walking (1.3m/s) and running (3...
October 1, 2017: Knee
https://www.readbyqxmd.com/read/28946852/spatio-temporal-clustering-analysis-and-its-determinants-of-hand-foot-and-mouth-disease-in-hunan-china-2009-2015
#8
Xinrui Wu, Shixiong Hu, Abuaku Benjamin Kwaku, Qi Li, Kaiwei Luo, Ying Zhou, Hongzhuan Tan
BACKGROUND: Hand, foot and mouth disease (HFMD) is one of the highest reported infectious diseases with several outbreaks across the world. This study aimed at describing epidemiological characteristics, investigating spatio-temporal clustering changes, and identifying determinant factors in different clustering areas of HFMD. METHODS: Descriptive statistics was used to evaluate the epidemic characteristics of HFMD from 2009 to 2015. Spatial autocorrelation and spatio-temporal cluster analysis were used to explore the spatial temporal patterns...
September 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28946545/impact-of-foot-pronation-on-postural-stability-an-observational-study
#9
Ghada Mohamed Koura, Doaa Ayoub Elimy, Hamada Ahmed Hamada, Hossam Eddien Fawaz, Mohamed Hussein Elgendy, Ibtissam M Saab
OBJECTIVE: To investigate the effect of foot pronation on the dynamic balance including overall stability index (OAI), anteroposterior stability index (APSI) and mediolateral stability index (MLSI). METHODS: Forty participants from both sexes were selected from the Faculty of Physical Therapy, Cairo University, with a mean age of 23.55 ± 1.74 years. Subjects were divided into two groups: group A (8 males and 12 females) with foot pronation, and group B (9 males and 11 females) with normal feet...
September 15, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28944643/injury-rates-in-martial-art-athletes-anthropometric-parameters-and-training-volume-but-not-foot-morphology-indexes-are-predictive-risk-factors-for-lower-limb-injuries
#10
Jacopo A Vitale, Tito Bassani, Fabio Galbusera, Alberto Bianchi, Nicolò Martinelli
BACKGROUND: Previous studies attempted to identify possible risk factors for acute and overuse injuries in several sports disciplines such as running, gymnastics or team sports. Given the lack of scientific works focused on risk factors for lower limb injuries in martial arts, the present study was aimed to investigate foot anatomy, anthropometric measures, and other background information as possible risk factors of injury in barefoot athletes practicing judo, karate, kung fu, thai boxe, or aikido...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28943154/sex-differences-in-leg-dexterity-are-not-present-in-elite-athletes
#11
Emily L Lawrence, Lorenzo Peppoloni, Francisco J Valero-Cuevas
We studied whether the time-varying forces that control unstable foot-ground interactions provide insight into the neural control of dynamic leg function. Twenty elite (10F, 26.4±3.5yrs) and 20 recreational (10F, 24.8±2.4yrs) athletes used an isolated leg to maximally compress a slender spring designed to buckle at low forces while seated. The foot forces during the compression at the edge of instability quantify the maximal sensorimotor ability to control dynamic foot-ground interactions. Using the nonlinear analysis technique of attractor reconstruction, we characterized the spatial (interquartile range IQR) and geometric (trajectory length TL, volume V, and sum of edge lengths SE) features of the dynamical behavior of those force time series...
September 14, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28937802/epidemiology-of-stress-fractures-in-collegiate-student-athletes-2004-2005-through-2013-2014-academic-years
#12
Katherine H Rizzone, Kathryn E Ackerman, Karen G Roos, Thomas P Dompier, Zachary Y Kerr
CONTEXT:   Stress fractures are injuries caused by cumulative, repetitive stress that leads to abnormal bone remodeling. Specific populations, including female athletes and endurance athletes, are at higher risk than the general athletic population. Whereas more than 460 000 individuals participate in collegiate athletics in the United States, no large study has been conducted to determine the incidence of stress fractures in collegiate athletes. OBJECTIVE:   To assess the incidence of stress fractures in National Collegiate Athletic Association (NCAA) athletes and investigate rates and patterns overall and by sport...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28932308/ultrasonographic-enthesopathy-and-disease-activity-in-psoriatic-arthritis
#13
Mohieldin M Ahmed, Gehan Gamal Elolemy, Aziz K Alfeeli, Ayyoub B Baqer, Adela M Gad
BACKGROUND: To our knowledge, the correlation between ultrasonographic enthesopathy and severity in psoriatic arthritis (PsA) has been done before. However, the correlation between ultrasonography of enthesopathy and the Psoriatic Arthritis Disease Activity Score (PASDAS) have not been done. AIM: To compare the results of ultrasonographic enthesopathy of foot and PASDAS in PsA. MATERIALS AND METHODS: A total of 65 PsA patients were involved and divided into two groups...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28922490/risk-factors-for-football-injuries-in-young-players-aged-7-to-12-years
#14
Roland Rössler, Astrid Junge, Jiri Chomiak, Karel Němec, Jiri Dvorak, Eric Lichtenstein, Oliver Faude
OBJECTIVES: Football (soccer) is very popular amongst children. Little is known about risk factors for football injuries in children. The aim was to analyse potential injury risk factors in 7 to 12 year old players. DESIGN: Prospective epidemiological study. METHODS: We collected prospective data in Switzerland and the Czech Republic over two seasons. Coaches reported exposure of players (in hours), absence, and injury data via an internet-based registration system...
September 18, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28910392/karyotype-analysis-and-sex-determination-in-australian-brush-turkeys-alectura-lathami
#15
Madison T Ortega, Dustin J Foote, Nicholas Nees, Jason C Erdmann, Charles D Bangs, Cheryl S Rosenfeld
Sexual differentiation across taxa may be due to genetic sex determination (GSD) and/or temperature sex determination (TSD). In many mammals, males are heterogametic (XY); whereas females are homogametic (XX). In most birds, the opposite is the case with females being heterogametic (ZW) and males the homogametic sex (ZZ). Many reptile species lack sex chromosomes, and instead, sexual differentiation is influenced by temperature with specific temperatures promoting males or females varying across species possessing this form of sexual differentiation, although TSD has recently been shown to override GSD in Australian central beaded dragons (Pogona vitticeps)...
2017: PloS One
https://www.readbyqxmd.com/read/28880590/foot-pain-in-relation-to-ipsilateral-and-contralateral-lower-extremity-pain-in-a-population-based-study
#16
Alyssa B Dufour, Brian Halpern, Rock G Positano, Howard J Hillstrom, Marian T Hannan
BACKGROUND: Clinical observations note that foot pain can be linked to contralateral pain at the knee or hip, yet we are unaware of any community-based studies that have investigated the sidedness of pain. Because clinic-based patient samples are often different from the general population, the purpose of this study was to determine whether knee or hip pain is more prevalent with contralateral foot pain than with ipsilateral foot pain in a population-based cohort. METHODS: Framingham Foot Study participants (2002-2008) with information on foot, knee, and hip pain were included in this cross-sectional analysis...
July 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28865844/factors-affecting-lifespan-following-below-knee-amputation-in-diabetic-patients
#17
S Beyaz, Ü Ö Guler, G Ş Bagir
INTRODUCTION: Untreatable foot problems in diabetics may require lower extremity amputation, which has a high level of patient mortality. This high mortality rate is worse than most malignancies. The present study aimed to identify parameters that can be used to estimate survival in DM patients undergoing below-knee amputations for diabetic foot problems. MATERIALS AND METHODS: A total of 470 patients (299 males, 171 females) with a mean age of 64.32 years who underwent below-knee amputation for diabetic foot problems between 2004 and 2014 were enrolled in the study...
August 30, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28859075/plantar-pressures-are-elevated-in-people-with-longstanding-diabetes-related-foot-ulcers-during-follow-up
#18
Malindu E Fernando, Robert G Crowther, Peter A Lazzarini, Saiumaeswar Yogakanthi, Kunwarjit S Sangla, Petra Buttner, Rhondda Jones, Jonathan Golledge
OBJECTIVE: High plantar pressures are implicated in the development of diabetes-related foot ulcers. Whether plantar pressures remain high in patients with chronic diabetes-related foot ulcers over time is uncertain. The primary aim of this study was to compare plantar pressures at baseline and three and six months later in participants with chronic diabetes-related foot ulcers (cases) to participants without foot ulcers (controls). METHODS: Standardised protocols were used to measure mean peak plantar pressure and pressure-time integral at 10 plantar foot sites (the hallux, toes, metatarsals 1 to 5, mid-foot, medial heel and lateral heel) during barefoot walking...
2017: PloS One
https://www.readbyqxmd.com/read/28855818/combined-efficacy-of-vigna-radiata-l-r-wilczek-and-amorphophallus-paeoniifolius-dennst-nicolson-on-serum-lipids-in-albino-rats
#19
P B Benil, R Lekshmi, N Viswanathan, E Jollykutty, R Rajakrishnan, J Thomas, A H Alfarhan
Coronary Artery Disease (CAD) is a major killer disease throughout the world. Dyslipidemia is a major contributor to the risk of CAD. Several dietary articles traditionally used in India and other South Asian countries reduced dyslipidemia. The present study was undertaken to evaluate the combined effect of Mung bean (Vigna radiata) and Elephant foot yam (Amorphophallus paeoniifolius) on serum lipids and atherogenic indices in albino rats and to compare it with a standard drug Cholestyramine. Thirty healthy albino rats of both sexes (150-200 g) were randomized to 5 groups of 6 animals each...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28854497/influence-of-spine-surgery-on-the-ability-to-perform-an-emergency-stop-while-driving-a-car
#20
Ulf K Hofmann, Sina Wittmann, Alena N Fischer, Maurice Jordan, Martina M Feierabend, Ina-Christine Rondak, Ingmar Ipach, Falk Mittag
BACKGROUND: Spinal surgeries have strongly increased in number over the past decade. The question of when it is safe to resume driving is thereby one the most frequently asked questions that patients ask of their treating physician. OBJECTIVE: The aim of this study was to assess braking performance before and after spine surgery. METHODS: Reaction time, foot transfer time (together brake response time [BRT]), and brake force (BF) were evaluated in a drive simulator...
August 18, 2017: Journal of Back and Musculoskeletal Rehabilitation
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