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https://www.readbyqxmd.com/read/29235129/association-of-gene-polymorphisms-of-pattern-recognition-receptor-signalling-pathway-with-the-risk-and-severity-of-hand-foot-and-mouth-disease-caused-by-enterovirus-71-in-chinese-han-population
#1
Ya-Ping Li, Mei Li, Xiao-Li Jia, Hui-Ling Deng, Wen-Jun Wang, Feng-Ping Wu, Jun Wang, Shuang-Suo Dang
Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex- and age-matched children was included as a control...
December 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29214210/excitatory-synaptic-input-to-hilar-mossy-cells-under-basal-and-hyperexcitable-conditions
#2
Tristan P Hedrick, William P Nobis, Kendall M Foote, Toshiyuki Ishii, Dane M Chetkovich, Geoffrey T Swanson
Hilar mossy cells (HMCs) in the hippocampus receive glutamatergic input from dentate granule cells (DGCs) via mossy fibers (MFs) and back-projections from CA3 pyramidal neuron collateral axons. Many fundamental features of these excitatory synapses have not been characterized in detail despite their potential relevance to hippocampal cognitive processing and epilepsy-induced adaptations in circuit excitability. In this study, we compared pre- and postsynaptic parameters between MF and CA3 inputs to HMCs in young and adult mice of either sex and determined the relative contributions of the respective excitatory inputs during in vitro and in vivo models of hippocampal hyperexcitability...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29202994/functional-outcomes-following-surgical-site-infections-after-operative-fixation-of-closed-ankle-fractures
#3
Markus G Naumann, Ulf Sigurdsen, Stein Erik Utvåg, Knut Stavem
BACKGROUND: To compare the functional outcomes between patients with and without postoperative surgical-site infection (SSI) after surgical treatment in closed ankle fractures. METHODS: Retrospective cohort study with prospective follow-up. Of 1011 treated patients, 959 were eligible for inclusion in a postal survey. Functional outcomes were assessed using three self-reported questionnaires. RESULTS: In total 567 patients responded a median of 4...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29202429/low-back-pain-and-disability-in-individuals-with-plantar-heel-pain
#4
Shane McClinton, Carolyn F Weber, Bryan Heiderscheit
BACKGROUND: Lack of response to plantar heel pain (PHP) treatment may be related to unmanaged low back pain (LBP) and low back dysfunction, but a relationship between LBP and PHP has not been established. The purpose of this investigation was to compare the prevalence of LBP among individuals with and without PHP and to assess the association between low back disability and foot/ankle function. METHODS: A cross-sectional study compared the prevalence and likelihood of LBP in individuals with (n=27) and without (n=27) PHP matched to age, sex, BMI, foot posture, and foot mobility...
September 28, 2017: Foot
https://www.readbyqxmd.com/read/29198400/osteochondritis-dissecans-of-skeletal-elements-of-the-foot-in-a-19th-century-rural-farming-community-from-the-netherlands
#5
Irene Vikatou, Menno L P Hoogland, Andrea L Waters-Rist
Osteochondritis Dissecans (OD) is a pathological condition of the subchondral bone and surrounding cartilage of synovial joints, associated with strenuous activity and/or trauma. Reports of OD in archaeological skeletal remains are few and the majority demonstrate low OD prevalence (<1%). A predominantly 19th century skeletal sample from Middenbeemster, the Netherlands, was assessed for OD. The sample included adult individuals of both sexes. There were no definitive OD lesions in non-pedal elements, yet 12...
December 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29166293/applicability-of-the-calcaneal-apophysis-ossification-staging-system-to-the-modern-pediatric-population
#6
Samuel Q Li, Allen D Nicholson, Daniel R Cooperman, Raymond W Liu
BACKGROUND: The calcaneal apophysis ossification staging system is a novel method for assessing skeletal maturity. However, it was created using the same historic patient population that was used to create the Greulich and Pyle atlas of the hand and wrist, predominantly white children. It is unclear if the calcaneal apophysis ossification staging system is still applicable to the modern pediatric population and to children of other races. METHODS: We retrospectively studied 1327 benign lateral foot x-rays from modern white and black children...
November 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29135702/relationship-between-sensory-dysfunction-and-walking-speed-in-patients-with-clinically-isolated-syndrome
#7
Magdalena Krbot Skorić, Luka Crnošija, Tereza Gabelić, Ivan Adamec, Mario Habek
PURPOSE: The aim of this study was to investigate a relationship between sensory dysfunction examined with somatosensory-evoked potentials of the posterior tibial nerve (tSSEP) and walking speed in patients with clinically isolated syndrome. METHODS: In 120 patients (mean age 32.2 ± 8.7 years, 84 females), Expanded Disability Status Scale (EDSS), timed 25-foot walk test (T25FW), brain and spinal cord MRI, and tSSEP were performed. P40 latencies and N22a-P40 interlatencies were analyzed, and the z-score for each latency was calculated and combined into total tSSEP z-score...
November 7, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29135646/foot-structure-and-function-in-habitually-barefoot-and-shod-adolescents-in-kenya
#8
Herje Aibast, Paul Okutoyi, Timothy Sigei, Walter Adero, Danny Chemjor, Neford Ongaro, Noriyuki Fuku, Kenn Konstabel, Carol Clark, Daniel E Lieberman, Yannis Pitsiladis
Habitually barefoot (HB) children from the Kalenjin tribe of Kenya are known for their high physical activity levels. To date, there has been no comprehensive assessment of foot structure and function in these highly active and HB children/adolescents and link with overuse injuries. PURPOSE: The aim of this research is to assess foot structure, foot function, injury and physical activity levels in Kenyan children and adolescents who are HB compared with those who were habitually shod (HS)...
November 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29126043/biphasic-bioresorbable-scaffold-trufit-plug-%C3%A2-for-the-treatment-of-osteochondral-lesions-of-talus-6-to-8-year-follow-up
#9
Elvira Di Cave, Pierluigi Versari, Fabio Sciarretta, David Luzon, Lorenzo Marcellini
BACKGROUND: The ideal treatment of osteochondral lesions of the talus (OLT) is debatable. The TruFit plug has been investigated as a potential treatment method for osteochondral defects. This is a biphasic scaffold designed to stimulate cartilage and subchondral bone formation. The purpose of this retrospective study was to investigate the long-term functional and MRI outcomes of the TruFit Plug for the treatment of OLT. METHODS: Twelve consecutive patients treated from March 2007 to April 2009 for OLT were evaluated...
June 3, 2017: Foot
https://www.readbyqxmd.com/read/29121708/factors-associated-with-a-prolonged-length-of-hospital-stay-in-patients-with-diabetic-foot-a-single-center-retrospective-study
#10
Sang Kyu Choi, Cheol Keun Kim, Dong In Jo, Myung Chul Lee, Jee Nam Kim, Hyun Gon Choi, Dong Hyeok Shin, Soon Heum Kim
BACKGROUND: We conducted this study to identify factors that may prolong the length of the hospital stay (LHS) in patients with diabetic foot (DF) in a single-institution setting. METHODS: In this single-center retrospective study, we evaluated a total of 164 patients with DF, and conducted an intergroup comparison of their baseline demographic and clinical characteristics, including sex, age, duration of diabetes, smoking status, body mass index, underlying comorbidities (e...
November 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29095273/risk-factors-of-wound-infection-after-open-reduction-and-internal-fixation-of-calcaneal-fractures
#11
Jun Su, Xuecheng Cao
The aim of this study was to investigate the risk factors of wound infection after open reduction and internal fixation of calcaneal fractures.In all, 299 patients with 318 calcaneal fractures who underwent open reduction and internal fixation by a single surgeon were grouped according to different outcomes. We gathered the data on each patient including sex, age, injury mechanism, body mass index (BMI), time to operation, fracture type, associated injuries, treatment course, tourniquet time, blood loss, bone graft (yes or no), diabetes (yes or no), smoking history, and complications...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29092649/evaluation-of-the-keeogo%C3%A2-dermoskeleton
#12
Jonathan C Mcleod, Susie Jm Ward, Audrey L Hicks
PURPOSE: (1) To determine the specific functional characteristics of individuals with neurological impairments that may predict successful use of Keeogo™ dermoskeleton and (2) to quantify the specific benefit Keeogo™ provides to a regular user of the device. METHODS: Thirteen individuals (seven males; six females; 52 ± 4.6 years old) with mobility impairments due to neurological disease or injury were recruited. Berg Balance Sale (BBS) score and Timed Up and Go (TUG) performance were used to identify baseline characteristics in participants...
November 2, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29081918/seroprevalence-and-risk-factors-for-peste-des-petits-ruminants-and-selected-differential-diagnosis-in-sheep-and-goats-in-tanzania
#13
Emeli Torsson, Mikael Berg, Gerald Misinzo, Ida Herbe, Tebogo Kgotlele, Malin Päärni, Nils Roos, Anne-Lie Blomström, Karl Ståhl, Jonas Johansson Wensman
Introduction: Livestock husbandry is critical for food security and poverty reduction in a low-income country like Tanzania. Infectious disease is one of the major constraints reducing the productivity in this sector. Peste des petits ruminants (PPR) is one of the most important diseases affecting small ruminants, but other infectious diseases may also be present. Objective: The objective of this study was to determine the seroprevalence and risk factors for exposure to PPR, contagious caprine pleuropneumonia (CCPP), foot-and-mouth disease (FMD), bluetongue (BT), and bovine viral diarrhoea (BVD) in sheep and goats in Tanzania...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/29073775/comparison-of-hallux-rigidus-surgical-treatment-outcomes-between-active-duty-and-non-active-duty-populations-a-retrospective-review
#14
Marc D Jones, Kerry J Sweet
Background - Our aim of this study was to compare the long term outcomes of three different surgical procedures for the treatment of hallux rigidus (cheilectomy, decompressional osteotomy and arthrodesis) between active duty military and non-active duty patients. Methods - A retrospective review of 80 patients (95 feet) undergoing surgical treatment for hallux rigidus was performed. Telephonic survey was used to obtain postoperative outcome measures and subjective satisfaction. Additional data recorded and analyzed included age, sex, status of patient active duty or non-active duty, grade of hallux rigidus, surgical procedure performed, date of surgery, time to return to full activity, ability to return to full duty, and follow up time post-operatively...
October 26, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29045899/early-transcriptional-divergence-marks-virus-specific-primary-human-cd8-t-cells-in-chronic-versus-acute-infection
#15
David Wolski, Peter K Foote, Diana Y Chen, Lia L Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T Waring, Damien C Tully, Todd M Allen, Raymond T Chung, Jörg Timm, W Nicholas Haining, Arthur Y Kim, Thomas F Baumert, Georg M Lauer
Distinct molecular pathways govern the differentiation of CD8+ effector T cells into memory or exhausted T cells during acute and chronic viral infection, but these are not well studied in humans. Here, we employed an integrative systems immunology approach to identify transcriptional commonalities and differences between virus-specific CD8+ T cells from patients with persistent and spontaneously resolving hepatitis C virus (HCV) infection during the acute phase. We observed dysregulation of metabolic processes during early persistent infection that was linked to changes in expression of genes related to nucleosomal regulation of transcription, T cell differentiation, and the inflammatory response and correlated with subject age, sex, and the presence of HCV-specific CD4+ T cell populations...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29037928/melanoma-of-the-foot-is-associated-with-advanced-disease-and-poorer-survival
#16
Barbara E Adams, Peter D Peng, Mitzi L Williams
The purpose of the present study was to review the outcomes and assess the prognostic factors associated with foot melanoma. We hypothesized that primary melanoma of the foot would be more likely to present at an advanced stage and be associated with poorer outcomes. Both univariate and multivariate analyses were conducted to examine the relationships between patients' demographic, clinical, and pathologic characteristics and deaths within 5 years. Categorical data were summarized as frequencies and percentages and continuous variables as mean ± standard deviation...
October 13, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29032706/quality-and-predictors-of-diabetes-care-among-patients-with-schizophrenia-a-danish-nationwide-study
#17
Mette Jørgensen, Jan Mainz, Fabrizio Carinci, Reimar W Thomsen, Søren Paaske Johnsen
OBJECTIVE: Patients with schizophrenia have a high prevalence of diabetes, but data on diabetes care quality for these patients are limited. This nationwide study compared the quality of diabetes care among individuals with and without schizophrenia and identified predictors of care quality. METHODS: In a population-based cohort study, 83,813 individuals with diabetes seen at hospital outpatient clinics between 2005 and 2013, including 669 with comorbid schizophrenia, were identified from Danish registries...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28988348/insight-into-the-neuroendocrine-basis-of-signal-evolution-a-case-study-in-foot-flagging-frogs
#18
REVIEW
Lisa A Mangiamele, Matthew J Fuxjager
A hallmark of sexual selection is the evolution of elaborate male sexual signals. Yet, how the physiology of an animal changes to support a new or modified signal is a question that has remained largely unanswered. Androgens are important in regulating male reproductive behavior, therefore, selection for particular signals may drive the evolution of increased androgenic sensitivity in the neuro-motor systems underlying their production. Studies of the neuroendocrine mechanisms of anuran sexual signaling provide evidence to support this idea...
October 7, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28984811/dizziness-handicap-inventory-score-is-highly-correlated-with-markers-of-gait-disturbance
#19
Damiano Zanotto, Erin M Mamuyac, Adam R Chambers, John S Nemer, John A Stafford, Sunil K Agrawal, Anil K Lalwani
OBJECTIVE: To evaluate the association between Dizziness Handicap Inventory-Screening version (DHI-S) score and spatiotemporal gait parameters using SoleSound, a newly developed, inexpensive, portable footwear-based gait analysis system. STUDY DESIGN: Cross-sectional. PATIENTS: One hundred eighteen patients recruited from otology clinic. INTERVENTION(S): Subjects completed the DHI-S survey and four uninterrupted walking laps wearing SoleSound instrumented footwear on a hard, flat surface for 100 m...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28979615/-podiatric-risk-screening-in-patients-with-type-2-diabetes-in-antananarivo
#20
MULTICENTER STUDY
Sitraka Angelo Raharinavalona, Haritsiky Robertini Ramalanjaona, Nalisoa Andrianera, Andrinirina Dave Patrick Rakotomalala, George Ramahandridona
Diabetic foot disease heavily weighs upon diabetics, being a significant cause of morbidity and severe disability. Their prevention is indispensable. Our study aimed to reduce the rate of amputations in diabetics. We conducted a retrospective, descriptive, cross-sectional, multicenter study of podiatric risk screening in patients with type 2 diabetes in the Endocrinology Department at the University Hospital of Befelatanana and at the Amadia Clinic, Faravohitra, over a period of 6 months. The average age of our patients was 54...
2017: Pan African Medical Journal
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