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https://www.readbyqxmd.com/read/29341066/cerebral-near-infrared-spectroscopy-nirs-for-perioperative-monitoring-of-brain-oxygenation-in-children-and-adults
#1
REVIEW
Yun Yu, Kaiying Zhang, Ling Zhang, Huantao Zong, Lingzhong Meng, Ruquan Han
BACKGROUND: Various techniques have been employed for the early detection of perioperative cerebral ischaemia and hypoxia. Cerebral near-infrared spectroscopy (NIRS) is increasingly used in this clinical scenario to monitor brain oxygenation. However, it is unknown whether perioperative cerebral NIRS monitoring and the subsequent treatment strategies are of benefit to patients. OBJECTIVES: To assess the effects of perioperative cerebral NIRS monitoring and corresponding treatment strategies in adults and children, compared with blinded or no cerebral oxygenation monitoring, or cerebral oxygenation monitoring based on non-NIRS technologies, on the detection of cerebral oxygen desaturation events (CDEs), neurological outcomes, non-neurological outcomes and socioeconomic impact (including cost of hospitalization and length of hospital stay)...
January 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29328416/endotoxin-tolerance-induced-by-lipopolysaccharide-preconditioning-protects-against-surgery%C3%A2-induced-cognitive-impairment-in-aging-mice
#2
Zhijie Zhang, Muhuo Ji, Yanlin Liao, Jianjun Yang, Jun Gao
Postoperative cognitive dysfunction (POCD) is a clinical syndrome characterized by varying degrees of cognitive functional decline in patients following major surgery. Inflammation and a dysregulated innate immune system exert broad effects in the periphery and central nervous system, yet the mechanisms underlying POCD remain poorly understood and without effective therapy. It has been reported that modulation of the dysregulated inflammatory response with low‑dose lipopolysaccharide (LPS) preconditioning, a phenomenon additionally referred to as endotoxin tolerance, has the potential to reduce neuroinflammation, blood‑brain barrier disruption, and cognitive impairment in a number of disease states...
January 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29310468/lidocaine-dose-response-effect-on-postoperative-cognitive-deficit-meta-analysis-and-meta-regression
#3
Mohammad Reza Habibi, Valiollah Habibi, Ali Habibi, Aria Soleimani
The true influence of the perioperative intravenous lidocaine on the development of postoperative cognitive deficit (POCD) in coronary artery bypass grafting (CABG) remains controversial. The principal aim is to undertake a meta-regression to determine whether moderator variables mediate the relationship between lidocaine and POCD. Areas covered: We searched the Web of Science, PubMed database, Scopus and the Cochrane Library database (up to June 2017) and systematically reviewed a list of retrieved articles...
January 9, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29289253/swiss-symposium-in-point-of-care-diagnostics-at-hes-so-valais
#4
Elsbeth Heinzelmann
When an innovative technology is going to be implemented in hospitals, medical practices or pharmacies, it often does not appear really new to researchers. It is the implementation itself and the domain where it is used that are at the core of innovation. That's why the SWISS SYMPOSIUM in Point-of-Care Diagnostics (POCD) brings together key stakeholders from research and industry to clinical settings and patient care to exchange knowledge and experience and to stimulate activities in POCD.
December 1, 2017: Chimia
https://www.readbyqxmd.com/read/29275267/the-correlation-of-the-depth-of-anesthesia-and-postoperative-cognitive-impairment-a-meta-analysis-based-on-randomized-controlled-trials
#5
Xing Lu, Xin Jin, Suwei Yang, Yanfei Xia
STUDY OBJECTIVE AND BACKGROUND: To comprehensively evaluate the associations between the depth of anesthesia and postoperative delirium (POD) or postoperative cognitive dysfunction (POCD). DESIGN: Using the Cochrane evaluation system, the included studies were conducted with quality assessment. DATA SOURCES: We searched Cochrane library, Embase and PubMed databases without language restriction. The retrieval time is up to August 2017. ELIGIBILITY CRITERIA: According to the PRISMA guideline, the results associated with POCD and POD separately were compared between low and high bispectral index (BIS) groups under fixed effects model or random effects model...
December 21, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29274670/prediction-of-organ-confined-disease-after-robot-assisted-radical-prostatectomy-in-patients-with-clinically-locally-advanced-prostate-cancer
#6
Ho Won Kang, Hae Do Jung, Joo Yong Lee, Jong Kyou Kwon, Seong Uk Jeh, Kang Su Cho, Won Sik Ham, Young Deuk Choi
BACKGROUND: Little is known about the preoperative predictive factors that could identify subsets of favorable patients who can be possibly cured with robot-assisted radical prostatectomy (RARP) alone in locally advanced prostate cancer (LAPCa). Our study was designed to identify clinical predictors of pathologic organ-confined disease (pOCD) in RARP setting. METHODS: Between 2007 and 2013, clinicopathological and oncological data from 273 consecutive men undergoing robot-assisted RP with extended PLND for clinically LAPCa were reviewed in a single-institution, retrospectively...
December 20, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29260313/post-operative-cognitive-decline-pocd-after-gynaecologic-surgery-current-opinions-and-future-applications
#7
Zarbo Cristina, Brivio Michela, Brugnera Agostino, Malandrino Chiara, Trezzi Gaetano, Rabboni Massimo, Bondi Emi, Compare Angelo, Frigerio Luigi
OBJECTIVE: Postoperative cognitive decline (POCD) is known to occur quite frequently after a cardiac surgery, especially in older population. Few studies specifically focused on its incidence and characteristics in gynecological setting. METHODS: Current opinions and future applications of POCD studies in gynecological setting have been discussed. RESULT: There are still many questions and issues about POCD in gynecological setting that remain unanswered as well as numerous research fields that have not been still explored...
December 19, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29259553/indication-of-cognitive-change-and-associated-risk-factor-after-thoracic-surgery-in-the-elderly-a-pilot-study
#8
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery is aging. Methods: Cognitive function was measured for all subjects (n = 12) before and after surgery using three different cognitive tests: Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), and a computerized Cogstate Brief Battery (CBB)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29258285/point-of-care-diagnostics-recent-advances-and-trends
#9
EDITORIAL
Sandeep Kumar Vashist
Recent years have witnessed tremendous advances in point-of-care diagnostics (POCD), which are a result of continuous developments in biosensors, microfluidic, bioanalytical platforms, assay formats, lab-on-a-chip technologies, and complementary technologies. This special issue targets the critical advances in POCD and provides guided insights and directions for future research.
December 18, 2017: Biosensors
https://www.readbyqxmd.com/read/29249869/short-term-postoperative-cognitive-dysfunction-and-inflammatory-response-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-pilot-study
#10
Hui Yu, Rui Dong, Yayuan Lu, Xi Yang, Chang Chen, Zongze Zhang, Mian Peng
Objectives: To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Design: A prospective cohort study. Setting: University medical centre. Participants: Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants. Measurements: The inflammatory marker levels in plasma and cognitive function were measured...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29239315/the-role-of-general-anesthetics-and-the-mechanisms-of-hippocampal-and-extra-hippocampal-dysfunctions-in-the-genesis-of-postoperative-cognitive-dysfunction
#11
REVIEW
Marco Cascella, Sabrina Bimonte
Postoperative cognitive dysfunction (POCD) is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and amplifying a complex cascade involving the immuno-hormonal activation, the micro circle alterations, the hippocampal oxidative stress activation and, finally, an increased blood-brain barrier's permeability. While the role of anesthetics in the POCD's genesis in humans is debated, a huge number of preclinical studies have been conducted on the topic and many mechanisms have been proposed to explain the potential neurodegenerative effects of general anesthetics...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29231348/-effects-of-electroacupuncture-on-postoperative-cognitive-dysfunction-and-ang%C3%A2-at1r-in-the-hippocampus-in-aging-rats-induced-by-d-galactose
#12
Peipei Feng, Zhe Liu, Xin Wang, Wenjuan Wang, Gaimei Wang, Na Li
OBJECTIVE: To observe the effects of electroacupuncture (EA) on postoperative cognitive dysfunction (POCD) and AngⅡ/AT1R in the hippocampus in D-galactose-induced aging rats which received hepalobectomy, and to explore the possible mechanism of EA on POCD. METHODS: Eighty male Sprague-Dawley rats were randomly divided into a young control group (10 rats), a D-Galactose-induced aged (Da) group (10 rats), a Da+hepatolobectomy group (30 rats) and an EA group (30 rats)...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29201007/erythropoietin-attenuates-postoperative-cognitive-dysfunction-by-shifting-macrophage-activation-toward-the-m2-phenotype
#13
Jae Hoon Lee, Eun Hee Kam, So Yeon Kim, So Yeong Cheon, Eun Jung Kim, Seungsoo Chung, Ji-Hyun Jeong, Bon-Nyeo Koo
Postoperative cognitive dysfunction (POCD) may be driven by transference of the innate immune response to the brain after aseptic surgical damage. Macrophages are key mediators of innate immunity that can display a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. Erythropoietin (EPO) is a hematopoietic hormone that exerts anti-inflammatory effects by influencing macrophage function. We hypothesized that EPO would prevent POCD by promoting macrophage phenotype switching to the M2 phenotype post-surgery...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29187700/sevoflurane-preconditioning-ameliorates-lipopolysaccharide-induced-cognitive-impairment-in-mice
#14
Maiko Satomoto, Zhongliang Sun, Yushi U Adachi, Hiroyuki Kinoshita, Koshi Makita
Systemic inflammation induces brain neuronal inflammation, in turn causing acute cognitive disorders. Furthermore, neuronal inflammation is one cause of postoperative cognitive disorder (POCD) and delirium. However, no sufficiently established pharmacological treatment is available for neurocognitive inflammation. This study evaluated the possible neuroprotective effects of preconditioning with sevoflurane anesthesia on cognition and neuroinflammatory changes in an animal model of lipopolysaccharide (LPS)-induced systemic inflammation...
November 29, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29187661/-inflammation-relevant-mechanisms-for-postoperative-cognitive-dysfunction-and-the-preventive-strategy
#15
Yujie Tang, Wen Ouyang
Postoperative cognitive dysfunction (POCD) is thought to be a mild cognitive disorder. It means that patients without cognitive diseases before surgery suffer from subtle changes in psychomotility, personality, social skills and cognitive function after the surgery. A decline in memory is the core characteristics of these symptoms. POCD is mainly seen in the elderly people following surgery. It can prolong hospital stay, reduce quality of life, increase mortality, and thus aggravate the burden of public health...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29180259/post-operative-cognitive-dysfunction-an-exploration-of-the-inflammatory-hypothesis-and-novel-therapies
#16
REVIEW
David R Skvarc, Michael Berk, Linda K Byrne, Olivia M Dean, Seetal Dodd, Matthew Lewis, Andrew Marriott, Eileen M Moore, Gerwyn Morris, Richard S Page, Laura Gray
Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways...
January 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29171485/-intraoperative-cerebroprotection-in-total-intravenous-anesthesia-in-children-of-school-age
#17
A M Ovezov, M V Panteleeva, A V Lugovoy
AIM: To improve the quality of anesthesia in school-age children by using intraoperative metabolic-mediated cerebroprotection to reduce the incidence of cognitive impairment after total intravenous anesthesia based on propofol. MATERIAL AND METHODS: A randomized, prospective, longitudinal clinical study was conducted, involving 60 school-age children operated under total intravenous anesthesia on the basis of propofol. Children were randomized into two equal groups...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29165767/influence-of-laryngeal-mask-airway-lma-insertion-anesthesia-on-cognitive-function-after-microsurgery-in-pediatric-neurosurgery
#18
C-H Fan, B Peng, F-C Zhang
OBJECTIVE: To compare the influence of laryngeal mask airway (LMA) insertion anesthesia and endotracheal intubation on cognitive function during anesthesia for neurosurgery microscopy. PATIENTS AND METHODS: A total of 76 pediatric patients who underwent neurosurgery microscopy were selected. They were randomly divided in the LMA insertion group with 35 cases and the endotracheal intubation group with 41 cases. Before the operation, the two groups were injected with 0...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164774/task-related-changes-in-degree-centrality-and-local-coherence-of-the-posterior-cingulate-cortex-after-major-cardiac-surgery-in-older-adults
#19
Jeffrey N Browndyke, Miles Berger, Patrick J Smith, Todd B Harshbarger, Zachary A Monge, Viral Panchal, Tiffany L Bisanar, Donald D Glower, John H Alexander, Roberto Cabeza, Kathleen Welsh-Bohmer, Mark F Newman, Joseph P Mathew
OBJECTIVES: Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and nonsurgical controls. EXPERIMENTAL DESIGN: Older cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals...
November 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29161395/postoperative-cognitive-dysfunction-and-dementia-what-we-need-to-know-and-do
#20
M J Needham, C E Webb, D C Bryden
Approximately 12% of apparently previously cognitively well patients undergoing anaesthesia and noncardiac surgery will develop symptoms of cognitive dysfunction after their procedure. Recent articles in this Journal have highlighted the difficulties of confirming any clear links between anaesthesia and cognitive dysfunction, in part because of the lack of consistency regarding definition and diagnosis. Postoperative cognitive dysfunction (POCD) is usually self-limiting and rarely persists in the longer term, although plausible biological mechanisms for an impact on brain protein deposition do exist...
December 1, 2017: British Journal of Anaesthesia
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