keyword
https://read.qxmd.com/read/38534263/claudin-4-upregulation-in-acantholytic-and-autoimmune-mediated-bullous-disorders
#1
JOURNAL ARTICLE
Chau M Bui, Huy G Vuong, Minh-Khang Le, Kristin J Rybski, Hatice B Zengin, Haiming Tang, Bruce R Smoller
Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The aim of this study is to illustrate claudin-4 immunohistochemical staining patterns of different blistering disorders. We collected 35 cases, including two Hailey-Hailey disease, one Darier disease, three Grover disease, one acantholytic acanthoma, two warty dyskeratoma, 11 pemphigus vulgaris (PV) including six mucosal PV, and two pemphigus foliaceus...
December 21, 2023: Dermatopathology (Basel, Switzerland)
https://read.qxmd.com/read/38526344/a-genome-sequence-for-the-threatened-whitebark-pine
#2
JOURNAL ARTICLE
David B Neale, Aleksey V Zimin, Amy Meltzer, Akriti Bhattarai, Maurice Amee, Laura Figueroa Corona, Brian J Allen, Daniela Puiu, Jessica Wright, Amanda R De La Torre, Patrick E McGuire, Winston Timp, Steven L Salzberg, Jill L Wegrzyn
Whitebark pine (WBP, Pinus albicaulis) is a white pine of subalpine regions in western contiguous US and Canada. WBP has become critically threatened throughout a significant part of its natural range due to mortality from the introduced fungal pathogen white pine blister rust (WPBR, Cronartium ribicola) and additional threats from mountain pine beetle (Dendroctonus ponderosae), wildfire, and maladaptation due to changing climate. Vast acreages of WBP have suffered nearly complete mortality. Genomic technologies can contribute to a faster, more cost-effective approach to the traditional practices of identifying disease-resistant, climate-adapted seed sources for restoration...
March 25, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38524655/capecitabine-and-oxaliplatin-induced-steven-johnson-syndrome-following-nivolumab-in-a-patient-of-metastatic-esophageal-carcinoma
#3
JOURNAL ARTICLE
Sumit Kumar, Anthialisha Nongkynrih, Biswajit Dey, Vikas Jagtap, Reena Lamba, Deiwakor Chyrmang
Stevens-Johnson syndrome presents as mucocutaneous blistering and sloughing, which may follow a devastating clinical course. Although Stevens-Johnson syndrome has been reported following the administration of anticancer drugs, only a few cases induced by cytotoxic anticancer drugs, administered after immune checkpoint inhibitors, have been reported. The present report describes a case of Stevens-Johnson syndrome caused by capecitabine and oxaliplatin (CAPEOX) combination chemotherapy, in a patient with esophageal squamous cell carcinoma, who had been previously treated with nivolumab...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38520339/industrially-scalable-textile-sensing-interfaces-for-extended-artificial-tactile-and-human-motion-monitoring-without-compromising-comfort
#4
JOURNAL ARTICLE
Fameng Wang, Haoyun Li, Pengpeng Hu, Yudong Wang, Fuwang Guan, Xuzhong Su, Mohammad Irfan Iqbal, Fengxin Sun
Smart wearables with the capability for continuous monitoring, perceiving, and understanding human tactile and motion signals, while ensuring comfort, are highly sought after for intelligent healthcare and smart life systems. However, concurrently achieving high-performance tactile sensing, long-lasting wearing comfort, and industrialized fabrication by a low-cost strategy remains a great challenge. This is primarily due to critical research gaps in novel textile structure design for seamless integration with sensing elements...
March 23, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38516144/the-clinical-characteristics-and-risk-factors-for-necrotizing-soft-tissue-infection-in-children
#5
JOURNAL ARTICLE
Jing Liu, Jigang Chen, Yanni Wang, Hongyan Qi, Jing Yu
IMPORTANCE: Necrotizing soft tissue infection (NSTI) is a serious infectious disease. However, the early clinical manifestations and indicators of NSTI in children are still unclear. OBJECTIVE: The purpose of this study was to analyze the clinical characteristics and risk factors of NSTI in pediatric patients. METHODS: A total of 127 children with skin and soft tissue infection (SSTI) were treated at our hospital and divided into two groups: the NSTI group and the non-NSTI group, based on their discharge diagnosis from January 2011 to December 2022...
March 2024: Pediatric Investigation
https://read.qxmd.com/read/38511666/image-based-non-invasive-assessment-of-suction-blister-wounds-for-clinical-safety-and-efficacy
#6
JOURNAL ARTICLE
Karl Wallblom, Sigrid Lundgren, Karim Saleh, Artur Schmidtchen, Manoj Puthia
Recognising the need for objective imaging-based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography-based imaging techniques utilising the suction blister wound model. Our method encompasses a protocol for capturing consistent, high-quality photographs and procedures for quantifying these images via a visual wound healing score and a computer-assisted colour analysis of wound exudation and wound redness...
March 21, 2024: Wound Repair and Regeneration
https://read.qxmd.com/read/38508975/targeting-antibody-mediated-complement-independent-mechanism-in-bullous-pemphigoid-with-diacerein
#7
JOURNAL ARTICLE
Yung-Tsu Cho, Chih-Hung Lee, Jing-Yi Lee, Chia-Yu Chu
BACKGROUND: Bullous pemphigoid (BP) is an antibody-mediated blistering disease predominantly affecting the elderly. The pathogenesis involves both complement-dependent and complement-independent mechanisms. The therapeutic potential of targeting complement-independent mechanism has not yet been determined. The mainstay of treatment, corticosteroid, has many side effects, indicating the needs of better treatments. OBJECTIVE: We tempted to establish an in vitro model of BP which resembles complement-independent mechanism and to examine the therapeutic potential of a novel anti-inflammatory agent, diacerein...
March 6, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38507442/a-case-of-bullous-pemphigoid-following-administration-of-anti-il-31-receptor-a-antibody
#8
JOURNAL ARTICLE
Ryosuke Masuyuki, Emi Sato, Shinichi Imafuku
Bullous pemphigoid (BP), an autoimmune bullous dermatosis, occurs predominantly in older individuals. Nemolizumab, a humanized monoclonal antibody against the interleukin (IL)-31 receptor A, is used to treat severe atopic dermatitis (AD) in Japan. However, it can cause several adverse events, such as exacerbation of AD, erythema, and eosinophilia. Herein, we describe a case of prurigo-type AD developing BP after nemolizumab administration. A 62-year-old man with prurigo-type AD and asthma presented with serious, refractory itching...
March 20, 2024: Journal of Dermatology
https://read.qxmd.com/read/38507104/integrative-approach-using-network-pharmacology-bioinformatics-and-experimental-methods-to-explore-the-mechanism-of-cantharidin-in-treating-colorectal-cancer
#9
JOURNAL ARTICLE
Benchao Hou, Xiaomin Wang, Zhijian He, Haiyun Liu
Cantharidin, a terpenoid produced by blister beetles, has been used in traditional Chinese medicine to treat various ailments and cancers. However, its biological activity, impact, and anticancer mechanisms remain unclear. The Cantharidin chemical gene connections were identified using various databases. The GSE21815 dataset was used to collect the gene expression information. Differential gene analysis and gene ontology analyses were performed. Gene set enrichment analysis was used to assess the activation of disease pathways...
March 20, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38506824/orofacial-anomalies-in-kindler-epidermolysis-bullosa
#10
JOURNAL ARTICLE
Susanne Krämer, Anna Lena Hillebrecht, Yao Wang, Mihail-Alexandru Badea, Jose Ignacio Barrios, Sorina Danescu, Ignacia Fuentes, Demet Kartal, Alfred Klausegger, Enrique Ponce de León, Reinhard Schilke, Ivelina Yordanova, Agnes Bloch-Zupan, Cristina Has
IMPORTANCE: Kindler epidermolysis bullosa is a genetic skin-blistering disease associated with recessive inherited pathogenic variants in FERMT1, which encodes kindlin-1. Severe orofacial manifestations of Kindler epidermolysis bullosa, including early oral squamous cell carcinoma, have been reported. OBJECTIVE: To determine whether hypoplastic pitted amelogenesis imperfecta is a feature of Kindler epidermolysis bullosa. DESIGN, SETTINGS, AND PARTICIPANTS: This longitudinal, 2-center cohort study was performed from 2003 to 2023 at the Epidermolysis Bullosa Centre, University of Freiburg, Germany, and the Special Care Dentistry Clinic, University of Chile in association with DEBRA Chile...
March 20, 2024: JAMA Dermatology
https://read.qxmd.com/read/38506139/recurrent-financial-crises-and-the-u-s-federal-reserve-bubbles-and-blisters
#11
JOURNAL ARTICLE
Mohammed H I Dore
The U.S. Federal Reserve now controls a part of the money supply, but other financial institutions, called the 'shadow' banks, issue a growing amount of the money supply, which remains outside the control of the U.S. Federal Reserve. Being unregulated, these shadow banks operate by offering highly risky amounts of credit, leading to lack of confidence and consequent run on such banks. However, due to competition with the shadow banks, the commercial banks have undergone structural change and are themselves engaged in trading the same financial assets as traded by the shadow banks...
April 2024: Nonlinear Dynamics, Psychology, and Life Sciences
https://read.qxmd.com/read/38505682/effects-of-a-leave-on-product-on-the-strength-of-the-dermoepidermal-junction-an-exploratory-intraindividual-randomized-controlled-trial-in-older-adults-with-dry-skin
#12
JOURNAL ARTICLE
Ruhul Amin, Fiorenza Rancan, Kathrin Hillmann, Ulrike Blume-Peytavi, Annika Vogt, Jan Kottner
BACKGROUND AND AIMS: Skin aging is associated with dry skin and a decrease of the strength of the dermoepidermal adhesion, which increases the risk for lacerations (skin tears). Application of leave-on products improves dry skin and seems to reduce skin tear incidence. The aim of this study was to measure the effects of a humectant containing leave-on product on the strength of the dermoepidermal junction in older adult participants with dry skin. METHODS: A randomized controlled trial using a split body design was conducted...
March 2024: Health Science Reports
https://read.qxmd.com/read/38505433/beyond-the-surface-a-clinical-insight-into-a-60-year-old-male-with-pemphigus-vulgaris
#13
Miis Akel, Maggie Wright, Bialo Aladum, Sergio Hernandez Borges
Pemphigus vulgaris, a rare and life-threatening autoimmune disorder, presents with painful skin and mucosal lesions, leading to blistering sores attributed to acantholysis. This study delves into the clinical manifestations, risk factors, and diagnostic intricacies associated with pemphigus vulgaris, with a focus on a representative case highlighting the challenges in its recognition and management. We explore the case of a 60-year-old male with pemphigus vulgaris, whose initial presentation involved yellow-crusting lesions on the scalp progressing to non-pruritic lesions on the chest, neck, and inguinal areas...
February 2024: Curēus
https://read.qxmd.com/read/38505015/myocardial-protection-comparing-histological-effects-of-single-dose-cardioplegic-solutions-study-protocol-for-a-secondary-analysis-of-the-cardioplegia-trial
#14
JOURNAL ARTICLE
Kathize Betti Lira, Renan Senandes Delvaux, Felipe Abatti Spadini, Luis Henrique Hauschild, Rafael Oliveira Ceron, Fernando Anschau, Luciane Kopittke, Juarez Rode, Rafael Antônio Widholzer Rey, Estefania Inez Wittke, Alfeu Roberto Rombaldi, Eduardo Cambruzzi, Eron Rodrigues Cunha Lopes, Adriana Silveira Almeida
BACKGROUND: Myocardial protection is crucial for successful cardiac surgery, as it prevents heart muscle damage that can occur during the procedure. Prolonged hypoxia without proper protection can lead to adenosine triphosphate consumption, microvilli loss, blister formation, and edema. Custodiol, del Nido, and modified del Nido are single-dose cardioplegic solutions with proven safety and significance in modern surgery. While each has been independently assessed for patient outcomes, limited research directly compares them...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38504438/beyond-the-skin-b-cells-in-pemphigus-vulgaris-tolerance-and-treatment
#15
JOURNAL ARTICLE
Anne-Lise Strandmoe, Jeroen Bremer, Gilles F H Diercks, Antoni Gostyński, Emanuele Ammatuna, Hendri H Pas, Marjan Wouthuyzen-Bakker, Gerwin A Huls, Peter Heeringa, Jon D Laman, Barbara Horváth
Pemphigus vulgaris is a rare autoimmune bullous disease characterized by blistering of the skin and mucosa owing to the presence of autoantibodies against the desmosome proteins desmoglein 3 and occasionally in conjunction with desmoglein 1. Fundamental research into the pathogenesis of PV has revolutionized its treatment and outcome with rituximab, a B-cell-depleting therapy. The critical contribution of B cells to the pathogenesis of pemphigus is well accepted. However, the exact pathomechanism, mechanisms of onset, disease course, and relapse remain unclear...
March 20, 2024: British Journal of Dermatology
https://read.qxmd.com/read/38500480/introduction-of-unit-dose-care-in-the-1-125-bed-teaching-hospital-practical-experience-and-time-saving-on-wards
#16
JOURNAL ARTICLE
Saskia Herrmann, Jana Giesel-Gerstmeier, Thomas Steiner, Florian Lendholt, Dominic Fenske
PURPOSE: The shortage of nursing staff as well as the slow progress in the German health care system's digitalisation has gained much attention due to COVID-19. Patient-specific medication management using the unit-dose dispensing system (UDDS) has the potential for a lasting and positive influence on both digitalisation and the relief of nursing staff. METHODS: Nursing staff UDDS-acceptance was determined via a validated online survey. For the evaluation of stock keeping on the wards, the delivery quantities were determined for a comparative period before and after the introduction of the UDDS...
2024: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/38497579/aneurysms-located-beyond-the-origin-of-the-major-branches-in-the-posterior-circulation
#17
JOURNAL ARTICLE
Sang-Jeong Song, Yoon-Soo Lee, Sang-Jun Suh
AIM: To evaluate the clinical and radiological features, treatment modalities, and outcomes of unusual aneurysms located beyond the origin of the major branches in the posterior circulation, and to introduce changes in the recent treatment trends due to rapid innovations in endovascular technology. MATERIAL AND METHODS: This was a retrospective study of patients who underwent treatment for these unusual aneurysms, including those that were identified in regular follow-up after treatment, between March 2009 and April 2023...
September 27, 2023: Turkish Neurosurgery
https://read.qxmd.com/read/38496187/a-case-report-of-mycosis-fungoides-presenting-with-blister-formation
#18
Hirofumi Kawamoto, Natsuko Saito-Sasaki, Yumiko Sakuragi, Yu Sawada
Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma with a usually indolent course. Early detection is crucial for effective intervention. We present a case of a 40-year-old male with MF exhibiting blistering as a rare precursor symptom. Despite initial treatment for eczema, the condition worsened over 10 months, leading to erythema, edema, and enlarged lymph nodes. Laboratory and imaging findings confirmed the diagnosis of MF. The patient responded partially to cyclophosphamide/doxorubicin/prednisone in combination with brentuximab vedotin (A-CHP) therapy...
February 2024: Curēus
https://read.qxmd.com/read/38496106/a-case-series-of-paederus-dermatitis-understanding-its-varied-and-diverse-clinical-presentations
#19
JOURNAL ARTICLE
Bhanupriya Tamilselvan, Srikanth Shanmugam, Pragasam Shakthi
Introduction  Paederus dermatitis arises from inadvertent skin contact with insects of the genus Paederus , leading to irritant contact dermatitis. This study aims to highlight the diverse clinical presentations and the remarkable ability of the disease to mimic various dermatological conditions.  Methodology  A total of 15 patients diagnosed with Paederus dermatitis in a period of four months from August 2023 to November 2023 were included in this retrospective study. The demographic profile, detailed history, clinical presentation, and site of lesion distribution were documented...
February 2024: Curēus
https://read.qxmd.com/read/38494777/mpox-virus-clade-iib-infected-cynomolgus-macaques-via-mimic-natural-infection-routes-closely-resembled-human-mpox-infection
#20
JOURNAL ARTICLE
Qingni Li, Yunfeng Chen, Wenjing Zhang, Chunyang Li, Ding Tang, Wanlu Hua, Fan Hou, Zhuo Chen, Yuanlang Liu, Yi Tian, Kaili Sun, Xiuli Xu, Yan Zenga, Fei Xia, Jia Lu, Zejun Wang
Generating an infectious non-human primate (NHP) model using a prevalent monkeypox virus (MPXV) strain has emerged as a crucial strategy for assessing the efficacy of vaccines and antiviral drugs against human MPXV infection. Here, we established an animal model by infecting cynomolgus macaques with the prevalent MPXV strain, WIBP-MPXV-001, and simulating its natural routes of infection. A comprehensive analysis and evaluation were conducted on three animals, including monitoring clinical symptoms, collecting hematology data, measuring viral loads, evaluating cellular and humoral immune responses, and examining histopathology...
March 17, 2024: Emerging Microbes & Infections
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