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https://www.readbyqxmd.com/read/29770226/massive-haemorrhagic-blister-formation-following-total-knee-arthroplasty
#1
Aadhar Sharma, Padmanabhan Subramanian, Sunil Shah, Mohan Remani, Muhammad Shahid
Skin blistering following trauma is not uncommon; however, large haemorrhagic bullous blisters following total knee arthroplasty is relatively rare and not widely documented in the literature.
May 2018: JRSM Open
https://www.readbyqxmd.com/read/29763476/drug-induced-linear-iga-bullous-dermatosis-in-a-patient-with-a-vancomycin-impregnated-cement-spacer
#2
Kelsie Riemenschneider, Daren A Diiorio, John A Zic, Matthew R Livingood, Jo-David Fine, Jennifer G Powers, Jeffrey P Zwerner, Eric Tkaczyk
Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously healthy 77-year-old man who developed a diffuse macular rash and hemorrhagic bullae on the left leg 10 days after placement of a vancomycin-impregnated cement spacer (VICS) during a revision knee arthroplasty and initiation of postoperative treatment with intravenous (IV) vancomycin...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29756688/localized-genital-bullous-pemphigoid
#3
S J Mounsey, K Heelan, S Hughes, H Fawcett, C B Bunker
Genital bullous pemphigoid (GBP) is a rare localized subset of bullous pemphigoid (BP). BP is characterized by autoantibodies against hemidesmosomes, which are involved in the structural integrity of the epidermis, and this results in subepidermal blistering. Typically, GBP affects women and children. We report an adult male who presented with a scrotal rash and blisters that developed into erosions. Only two previous cases in men have been reported. Immunofluoresence and histopathology confirmed the diagnosis of BP...
May 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29755451/autoantibody-signaling-in-pemphigus-vulgaris-development-of-an-integrated-model
#4
REVIEW
Thomas Sajda, Animesh A Sinha
Pemphigus vulgaris (PV) is an autoimmune skin blistering disease effecting both cutaneous and mucosal epithelia. Blister formation in PV is known to result from the binding of autoantibodies (autoAbs) to keratinocyte antigens. The primary antigenic targets of pathogenic autoAbs are known to be desmoglein 3, and to a lesser extent, desmoglein 1, cadherin family proteins that partially comprise the desmosome, a protein structure responsible for maintaining cell adhesion, although additional autoAbs, whose role in blister formation is still unclear, are also known to be present in PV patients...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29753472/investigating-the-properties-of-high-pressure-treated-reduced-sodium-low-moisture-part-skim-mozzarella-cheese-during-refrigerated-storage
#5
M Ozturk, S Govindasamy-Lucey, J J Jaeggi, M E Johnson, J A Lucey
We proposed that the performance and sensory properties of reduced-Na, low-moisture, part-skim (LMPS) Mozzarella cheese could be extended by the application of high hydrostatic pressure (HHP) to cheese postmanufacture and thereby decrease microbial and enzymatic activity. Fermentation-produced camel chymosin was also used as a coagulant to help reduce proteolysis during storage. Average composition of the LMPS Mozzarella cheeses was 48.6 ± 0.6% moisture, 22.5 ± 0.4% fat, 24.5 ± 0.6% protein, and 1.0 ± 0...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29752861/immunohistochemical-diagnosis-of-mucous-membrane-pemphigoid
#6
Iakov Shimanovich, Julia Marie Nitz, Mareike Witte, Detlef Zillikens, Christian Rose
BACKGROUND: Mucous membrane pemphigoid (MMP) is an autoimmune subepithelial blistering disease with predominant involvement of mucosal surfaces. It is usually diagnosed by direct immunofluorescence microscopy of frozen biopsies, demonstrating linear deposits of complement, IgG or IgA along the basement membrane. The aim of the present study was to investigate the utility of immunohistochemistry on formalin-fixed, paraffin-embedded tissue biopsies for the diagnosis of MMP and to compare its sensitivity to that of direct immunofluorescence microscopy...
May 12, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29750336/relapse-of-porphyria-cutanea-tarda-after-treatment-with-phlebotomy-or-4-aminoquinoline-antimalarial-a-meta-analysis
#7
H Salameh, H Sarairah, M Rizwan, Y-F Kuo, K E Anderson, A K Singal
INTRODUCTION: Porphyria cutanea tarda (PCT), the most common human porphyria, due to hepatic deficiency of uroporphyrinogen decarboxylase (UROD) activity, which is acquired in the presence of multiple susceptibility factors. PCT presents clinically with cutaneous blistering photosensitivity and is readily treatable with either repeated phlebotomy or 4-aminoquinoline antimalarial. We performed a systematic review and meta-analysis to compare the effectiveness of these quite different treatment approaches, especially on relapse rates after achieving remission...
May 11, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29749120/multiple-anogenital-hemorrhagic-blisters-in-a-2-year-old-girl
#8
Júlia Vide, Catarina Moreira, Ana Nogueira
No abstract text is available yet for this article.
May 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29749071/a-polymorphous-rash-of-an-uncommon-blistering-disease
#9
C H Tan, L Y Kuan, Y K Heng, J Y Pan, S I Tee, Y L Lim, L S Tan
No abstract text is available yet for this article.
May 10, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29746360/laxative-induced-contact-dermatitis
#10
Jennifer E Melvin, Robert W Hickey
A 5-year-old female with Charcot-Marie-Tooth neuropathy and a history of constipation presented to the emergency department with a new blistering buttocks rash, which was initially concerning for nonaccidental burn. Upon further investigation, it was found that Ex-Lax had been given to the patient for constipation. This had resulted in a bowel movement, which led to an irritant dermatitis. The patient was eventually diagnosed with senna-induced erosive diaper dermatitis. This case report highlights the importance of a thorough history and physical examination to prevent an unnecessary child abuse work-up...
May 9, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29745997/efficacy-of-human-placental-derived-stem-cells-in-collagen-vii-knockout-recessive-dystrophic-epidermolysis-bullosa-animal-model
#11
Yanling Liao, Larisa Ivanova, Rajarajeswari Sivalenka, Trevor Plumer, Hongwen Zhu, Xiaokui Zhang, Angela M Christiano, John A McGrath, Jodi P Gurney, Mitchell S Cairo
Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating inherited skin blistering disease caused by mutations in the COL7A1 gene that encodes type VII collagen (C7), a major structural component of anchoring fibrils at the dermal-epidermal junction (DEJ). We recently demonstrated that human cord blood-derived unrestricted somatic stem cells promote wound healing and ameliorate the blistering phenotype in a RDEB (col7a1-/- ) mouse model. Here, we demonstrate significant therapeutic effect of a further novel stem cell product in RDEB, that is, human placental-derived stem cells (HPDSCs), currently being used as human leukocyte antigen-independent donor cells with allogeneic umbilical cord blood stem cell transplantation in patients with malignant and nonmalignant diseases...
May 10, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29738046/blisters-sores-and-scars-on-the-dorsal-hands-in-a-17-year-old-girl-a-quiz
#12
Anna Trier Brix, Anne Lindegaard Christensen, Anette Bygum
No abstract text is available yet for this article.
May 8, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29735493/recurrent-blistering-distal-dactylitis-due-to-staphylococcus-aureus-in-an-immunocompetent-elderly-woman
#13
Colin A Hinkamp, Nikhil H Shah, Neal Holland, Ashleigh Wright
An 86-year-old woman presented with marked blistering of her left index fingertip and ulceration of the left middle fingertip, with a 2-year history of recurrent blistering and ulceration of her fingers bilaterally. She denied any preceding finger trauma, although she reported frequent gardening. She denied systemic symptoms. Her medical history was significant for a 2-year history of atrial fibrillation on carvedilol, amiodarone and apixaban, and she was a lifetime non-smoker. On admission, she had elevated inflammatory markers but unremarkable autoantibodies...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29731854/cantharidin-suppresses-cell-growth-and-migration-and-activates-autophagy-in-human-non-small-cell-lung-cancer-cells
#14
Yan-Peng Liu, Ling Li, Liang Xu, E-Nuo Dai, Wei-Da Chen
Cantharidin (CTD), a component of Mylabris (blister beetle), is a traditional Chinese medicine that exerts an anticancer effect in multiple types of cancer cells. The aim of the present study was to investigate whether CTD exhibited anti-metastatic and inhibitory cell proliferation effects against human non-small cell lung cancer (NSCLC) A549 cells, and the possible underlying mechanism by which this occurs. The results of the present study demonstrated that CTD arrested proliferation, suppressed invasion and migration and induced apoptosis in A549 cells in vitro ...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29731587/suction-blister-epidermal-grafting-for-vitiligo-involving-angles-of-lip-experience-of-112-patients
#15
Bikash R Kar, Chinmoy Raj
Background: Lip vitiligo is usually resistant to medical modalities of treatment, and in all these cases, surgery offers a hope. Suction blister grafting (SBG) has been tried since long for lip vitiligo with high rate of success. There have been no long-term follow-up studies of patients with SBG at a difficult-to-treat site like angles of lip, which prompted us to conduct this study. Aims and Objectives: To assess the pigmentation rate and patient satisfaction of SBG on vitiligo involving angles of lip...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29731556/caspase-cascade-pathways-of-apoptosis-in-oral-pemphigus-an-immunohistochemical-study
#16
Aparna K Sanath, A Santha Devy, Sanath Aithal, G Sathish Kumar, B Ganesh Prasad, P S Pradeep
Background: Pemphigus is a group of autoimmune blistering diseases characterized by loss of keratinocyte cell adhesion that leads to blister formation clinically. Induction of apoptosis or of proapoptotic proteins by pemphigus immunoglobulin G (IgG) may be part of the mechanism by which IgG induces acantholysis. Some of the current data suggest that activation of proapoptotic proteins such as bax and caspase cysteine proteinases may sensitize cells to the acantholytic effects of pemphigus IgG...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29730897/the-effect-of-autoimmune-blistering-diseases-on-work-productivity
#17
E Q Wang, M Radjenovic, M A Castrillón, G Feng, D F Murrell
BACKGROUND: Autoimmune blistering diseases (AIBD) is known to negatively impact upon quality of life (QoL), however there is a paucity of research on the effect of AIBD on work productivity. AIBD can be quite disfiguring in terms of a patient's appearance due to its blistering nature. OBJECTIVE: To determine the impact of AIBD on work productivity and to determine whether patients are stigmatized at work due to their appearance. METHODS: Sixty one patients with AIBD completed the Work Productivity and Activity Impairment Questionnaire-Specific Health Problem (WPAIQ-SHP), the Dermatology Life Quality Index (DLQI), the Autoimmune Bullous Disease Quality of Life (ABQOL), and the Treatment of Autoimmune Bullous Disease Quality of Life questionnaires (TABQOL)...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730882/beta-blockers-for-treatment-of-autoimmune-blistering-dermatosis
#18
Ayman Abdelmaksoud, Michelangelo Vestita
We read with interest a study by Miyamoto et al. published in the Journal of European Academy of Dermatology and Venereology. In their study, Miyamoto et al. found higher expression of vascular endothelial growth factor (VEGF) and endoglin in the tissue of erythrodermic pemphigus foliaceous (PF) compared to non-erythrodermic PF. According to the authors, both VEGF and endoglin may pose a prognostic predicting factors for adequate tissue repair in pemphigus patients; PF& pemphigus vulgaris (PV). The authors stated "therapy such as topical propranolol may enable adequate healing and disease remission"...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29722429/bart-s-syndrome-in-a-family-affected-three-consecutive-generations-with-mutation-c-6007g-a-in-col7a1
#19
Zhiming Chen, Wenbo Bu, Suying Feng, Hongsheng Wang
Bart's syndrome (BS), characterized by aplasia cutis congenita (ACC, also called congenital localized absence of skin) and epidermolysis bullosa (EB), is diagnosed clinically based on the disorder's unique signs and symptoms. We report the case of a family, three members of which presented with ACC at birth and one had blisters on the mucous membranes. The patient was treated conservatively with topical antibacterial ointment and wet gauze dressing. Periodic follow up showed complete healing with minimal scarring...
May 3, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29721625/-acute-life-threatening-drug-reactions-of-the-skin
#20
REVIEW
M Mockenhaupt
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acutely occurring, unpredictable, often life-threatening reactions that are a huge challenge in clinical practice. They are characterized by extensive blistering of skin and mucosa and are considered as one disease entity of different severity. Thus, they are summarized as SJS/TEN or EN (for epidermal or epithelial necrolysis). The diagnosis can be confirmed through synopsis of clinical pattern and histopathological findings. To identify the inducing factors, it is crucial to obtain a detailed and thorough medication and infection history...
May 2, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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