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https://www.readbyqxmd.com/read/28319279/borderline-lepromatous-leprosy-erythema-nodosum-leprosum-and-a-generalized-varicella-zoster-virus-infection
#1
Cornelis Kennedy, Bernard Naafs
We report the case of a thirty-year-old man with Mid-Borderline (BB) to Borderline Lepromatous Leprosy (BL) who was admitted to the hospital with blistering lesions on his upper and lower extremities. These lesions, which were partly filled with pus rapidly developed into erosions and ulcerations with hemorrhagic crusts. Other observations at time of admission included a tender erythematous plaque on his forehead, a drop foot on the right leg, muscle atrophy in both hands, a low grade fever, and pain and swelling in his right lower jaw...
March 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28317292/pigmentation-phenotype-photosensitivity-and-skin-neoplasms-in-patients-with-myotonic-dystrophy
#2
S M Gadalla, J E Hilbert, W B Martens, S Givens, R T Moxley, M H Greene
BACKGROUND AND PURPOSE: Recent studies have suggested a possible excess risk of skin neoplasms in patients with myotonic dystrophy (DM). Risk factors related to this observation have not been defined. METHOD: Information regarding personal history of skin tumors, pigmentation phenotype, and skin reaction to sun exposure were collected from 266 DM patients who were enrolled in the US National Institutes of Health National Registry of Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Patients and Family Members...
March 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28317060/prognostic-factors-for-mortality-in-patients-with-bullous-pemphigoid-a-meta-analysis
#3
Yi-Di Liu, Yan-Hong Wang, Yi-Cong Ye, Wen-Ling Zhao, Li Li
Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with BP. However, relatively few studies have investigated prognostic factors of BP mortality, and they showed considerably various results. This meta-analysis aimed to quantitatively assess the association between several potential prognostic factors and risk of mortality in bullous pemphigoid. A comprehensive search was performed using Pubmed, Embase, and Cochrane Library...
March 19, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28303284/-generalized-circumscribed-scleroderma-with-blisters
#4
G Wagner, V Meyer, M M Sachse
The patient suffered from a 20-year course of generalized circumscribed scleroderma and presented with blisters in circumscribed areas of the affected skin. The development of subepidermal blisters has been described in all clinical forms of circumscribed scleroderma. Aetiology and pathogenesis of blister formation have not yet been clarified. An obstruction of the lymphatic vessels due to the present sclerosis is favoured. Treatment of bullous circumscribed scleroderma is considered to be difficult. Oral steroids, methotrexate, hydroxychloroquine and PUVA methods have been used with varying success...
March 16, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28303283/-bullous-sweet-s-syndrome-with-pulmonary-involvement
#5
A Sesti, K Rappersberger, C Posch
Acute febrile neutrophilic dermatosis (Sweet's syndrome) is a rare dermatosis characterized by painful papules and plaques accompanied by cutaneous infiltration with neutrophilic granulocytes. Bullous changes are observed in some cases. We report about a patient with osteomyelofibrosis who developed fever accompanied by painful plaques and confluent papules on both arms and thighs. The course of the disease was complicated by blistering and pulmonary infiltrates. After the diagnosis of bullous Sweet's syndrome was established, systemic therapy with glucocorticoids was successful in treating skin lesions and dyspnea...
March 16, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28300888/vancomycin-associated-linear-iga-disease-mimicking-toxic-epidermal-necrolysis
#6
Amanda Regio Pereira, Luis Henrique Barbizan de Moura, Jhonatan Rafael Siqueira Pinheiro, Victor Pavan Pasin, Milvia Maria Simões E Silva Enokihara, Adriana Maria Porro
Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. The aim of this work is to emphasize the need to include this differential diagnosis in cases of epidermal detachment and to review the literature on the subject and this specific clinical presentation...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28300855/longitudinal-tracking-of-autoantibody-levels-in-a-pemphigus-vulgaris-patient-support-for-a-role-of-anti-desmoglein-1-autoantibodies-as-predictors-of-disease-progression
#7
Nadia Y Abidi, Irene Lainiotis, Gretchen Malikowski, Kristina Seiffert-Sinha, Animesh A Sinha
Anti-desmoglein (Dsg) 1 and -Dsg3 antibody titers have an established role in the diagnosis of the autoimmune blistering skin disease pemphigus vulgaris (PV). However, their usefulness for disease monitoring has been controversial. A recent large-scale immunoprofiling study by our group indicated that anti-Dsg1 levels may be a better predictor of disease activity than anti-Dsg3 levels, with declining levels predicting progression from active phase of disease to early remission, irrespective of lesional subtypes...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28298031/analysis-of-saccular-aneurysms-in-the-barrow-ruptured-aneurysm-trial
#8
Robert F Spetzler, Joseph M Zabramski, Cameron G McDougall, Felipe C Albuquerque, Nancy K Hills, Robert C Wallace, Peter Nakaji
OBJECTIVE The Barrow Ruptured Aneurysm Trial (BRAT) is a prospective, randomized trial in which treatment with clipping was compared to treatment with coil embolization. Patients were randomized to treatment on presentation with any nontraumatic subarachnoid hemorrhage (SAH). Because all other randomized trials comparing these 2 types of treatments have been limited to saccular aneurysms, the authors analyzed the current BRAT data for this subgroup of lesions. METHODS The primary BRAT analysis included all sources of SAH: nonaneurysmal lesions; saccular, blister, fusiform, and dissecting aneurysms; and SAHs from an aneurysm associated with either an arteriovenous malformation or a fistula...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298019/microsurgical-versus-endovascular-interventions-for-blood-blister-aneurysms-of-the-internal-carotid-artery-systematic-review-of-literature-and-meta-analysis-on-safety-and-efficacy
#9
Sumedh S Shah, Zachary C Gersey, Mohamed Nuh, Hesham T Ghonim, Mohamed Samy Elhammady, Eric C Peterson
OBJECTIVE Blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) have a poor natural history associated with high morbidity and mortality. Currently, both surgical and endovascular techniques are employed to treat BBAs; thus, the authors sought to perform a meta-analysis to compare the efficacy and safety of these approaches. METHODS A literature search of PubMed, MEDLINE, and Google Scholar online databases was performed to include pertinent English-language studies from 2005 to 2015 that discussed the efficacy and safety of either surgical or endovascular therapies to treat BBAs...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28295451/ccl20-neutralisation-by-a-monoclonal-antibody-in-healthy-subjects-selectively-inhibits-recruitment-of-ccr6-cells-in-an-experimental-suction-blister
#10
Gerben Bouma, Stefano Zamuner, Kirsty Hicks, Andrew Want, João Oliveira, Arpita Choudhury, Sara Brett, Darren Robertson, Leigh Felton, Virginia Norris, Disala Fernando, Michael Herdman, Ruth Tarzi
AIMS: GSK3050002, a humanized IgG1κ antibody with high binding affinity to human CCL20, was administered in a first-in-human study to evaluate safety, pharmacokinetics (PK) and pharmacodynamics (PD). An experimental skin suction blister model was employed to assess target engagement and the ability of the compound to inhibit recruitment of inflammatory CCR6 expressing cells. METHODS: This study was a randomized, double-blind (sponsor open), placebo-controlled, single-centre, single ascending intravenous dose escalation trial in 48 healthy male volunteers...
March 11, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28288394/blood-blister-like-aneurysms-in-tibetans-a-retrospective-observational-study
#11
Ruiqi Chen, Anqi Xiao, Hao Li, Lu Ma, Sen Lin, Chao You
OBJECT: Although research on blood blister-like aneurysms (BLAs) in different population is well documented, studies of that in the plateau area remain elusive. This study aimed to develop a better understanding of BLAs in Tibetan population, which is a typical representation of people in plateau area. METHODS: In this retrospective observational study, the hospital information system (HIS) was used to search for consecutive patients with BLAs by using the discharge diagnoses...
March 6, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28280713/stevens-johnson-syndrome-and-abuse-of-anabolic-steroids
#12
Serena Cocca, Massimo Viviano
Stevens-Johnson syndrome (SJS) is characterized by mucocutaneous tenderness and typical hemorrhagic erosions, erythema and epidermal detachment presenting as blisters and areas of denuded skin. SJS is often observed after drug use as well as after bacterial or viral infections. Several drugs are at high risk of inducing SJS, but there are no cases in the English literature regarding anabolic steroid use triggering SJS. In our paper, we describe a case in which use of anabolic androgenic steroids (AAS) was associated with SJS...
February 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28279484/doxycycline-versus-prednisolone-as-an-initial-treatment-strategy-for-bullous-pemphigoid-a-pragmatic-non-inferiority-randomised-controlled-trial
#13
Hywel C Williams, Fenella Wojnarowska, Gudula Kirtschig, James Mason, Thomas R Godec, Enno Schmidt, Joanne R Chalmers, Margaret Childs, Shernaz Walton, Karen Harman, Anna Chapman, Diane Whitham, Andrew J Nunn
BACKGROUND: Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over starting treatment with oral corticosteroids. METHODS: We did a pragmatic, multicentre, parallel-group randomised controlled trial of adults with bullous pemphigoid (three or more blisters at two or more sites and linear basement membrane IgG or C3)...
March 6, 2017: Lancet
https://www.readbyqxmd.com/read/28277872/assessing-the-stability-of-lamotrigine-dispersible-chewable-tablets-when-stored-in-blister-punch-cards
#14
Héctor R Loscertales, Pilar Modamio, Cecilia F Lastra, Eduardo L Mariño
OBJECTIVES: To determine the stability of lamotrigine dispersible/chewable tablets (DCT) when stored in blister punch cards (BPCs). METHODS: Lamotrigine 100 mg DCT were randomly repackaged into a U.S. Pharmacopeia Class A one-week cold-sealed BPC. Chemical and physical stability were evaluated over a 60-day period, in controlled conditions corresponding to Climatic Zones I/II (25°C ± 2°C; 60% ± 5% relative humidity). At scheduled times, various tests were performed on tablets in their primary packaging (reference samples) and on tablets repackaged (BPC samples)...
February 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28274366/pemphigus-vulgaris-and-pemphigus-foliaceus-determined-by-cd86-and-ctla4-polymorphisms
#15
Srdjan Tanasilovic, Svetlana Popadic, Ljiljana Medenica, Dusan Popadic
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are rare autoimmune blistering diseases with presumed T-cell-dependent pathology. Activation of naïve T cells is dependent on antigen recognition, subsequent signaling through the T-cell receptor complex (signal 1), and various other interactions of T cells with antigen presenting cells that may be collectively designated as signal 2, which is unconditionally required for T-cell activation both in response to infection and to autoantigens. Among the best described interactions contributing to signal 2 are those mediated by B7 family molecules, such as CD80 and CD86 with their ligands; CD28, providing activation signals; and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), conferring inhibition...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28273946/dysregulation-of-mcd46-and-scd46-contribute-to-the-pathogenesis-of-bullous-pemphigoid
#16
Pei Qiao, Erle Dang, Tianyu Cao, Hui Fang, Jieyu Zhang, Hongjiang Qiao, Gang Wang
Bullous pemphigoid (BP) is an autoimmune bullous disease caused by autoantibodies against BP180 in the epidermal basement membrane. Autoantibody-mediated complement activation is an important process in BP pathogenesis. CD46, a crucial complement regulatory protein in the complement activation, has been reported to be involved in several autoimmune diseases. In the present study, we investigated whether CD46 plays a role in BP development. We found that sCD46 expression was significantly increased in the serum and blister fluids of BP patients and correlated with the levels of anti-BP180 NC16A antibody and C3a...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28271571/gene-editing-for-skin-diseases-designer-nucleases-as-tools-for-gene-therapy-of-skin-fragility-disorders
#17
Oliver P March, Julia Reichelt, Ulrich Koller
The current treatment of inherited blistering skin diseases, such as epidermolysis bullosa (EB) is largely restricted to wound care and pain management. More effective therapeutic strategies are urgently required and targeting the genetic basis of these severe diseases is now within reach. Here we describe current gene editing tools and their potential to correct gene function in monogenetic blistering skin diseases. We present the features of the most frequently used gene editing techniques TALEN and CRISPR/Cas9, determining their preferential application under specific genetic conditions, including the type of mutational inheritance, the targeting site within the gene or the possibility to specifically target the mutation...
March 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28267595/economic-burden-of-herpes-zoster-culebrilla-in-latin-america
#18
Emmanouil Rampakakis, Clare Pollock, Claudia Vujacich, Joao Toniolo Neto, Alejandro Ortiz Covarrubias, Homero Monsanto, Kelly D Johnson
BACKGROUND: Herpes zoster (HZ) is characterized by debilitating pain and blistering dermatomal rash. The most common complication of HZ is postherpetic neuralgia (PHN), a persistent pain that can substantially affects patients' quality of life. HZ has significant impact on patients' lives with considerable implications for healthcare systems and society. The purpose of this study was to evaluate the healthcare resource utilization (HCRU) and medical costs associated with HZ in Latin America...
March 3, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28265392/hybrid-procedure-combining-clip-on-wrapping-and-stent-placement-for-ruptured-supraclinoid-blood-blister-like-aneurysm-of-the-internal-carotid-artery
#19
Hirokazu Nagasaki, Michihisa Narikiyo, Gota Nagayama, Seiya Nagao, Yoshifumi Tsuboi, Chisaku Kambayashi
Blood blister-like aneurysms of the supraclinoid portion of the internal carotid artery are rare, fragile, and thin-walled lesions with a higher rate of rebleeding. Our case underwent a hybrid procedure combining direct surgical and endovascular approach.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28264293/annotated-checklist-of-the-false-blister-beetles-coleoptera-tenebrionoidea-oedemeridae-from-iran
#20
Hassan Ghahari, Xavier A Vázquez, Daniel Kubisz
A checklist of Oedemeridae species recorded from Iran is given. A total of 48 species and subspecies are reported, of which two, Nacerdochroa caspia (Faldermann, 1836) and Oedemera (Oedemera) virescens virescens (Linnaeus, 1767), are recorded here for the first time from Iran. A total of 18 species (37,5%) are Iranian endemics. The most common chorotypes are Turanian (16 species; 33%), Turano-European (8 species; 17%), SW-Asiatic chorotype (7 species; 15%), Sindian (6 species; 13%) and Arabo-sindian (4 species, 8%)...
February 27, 2017: Zootaxa
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