keyword
https://read.qxmd.com/read/38256257/implication-of-lncrna-mstrg-81401-in-hippocampal-pyroptosis-induced-by-p2x7-receptor-in-type-2-diabetic-rats-with-neuropathic-pain-combined-with-depression
#21
JOURNAL ARTICLE
Ting Zhan, Shanshan Tang, Junpei Du, Jingshuang Liu, Bodong Yu, Yuxin Yang, Yuting Xie, Yanting Qiu, Guodong Li, Yun Gao
Major depressive disorder (MDD) is a common complication of diabetes and is often observed alongside diabetic neuropathic pain (DNP) as a comorbidity in diabetic patients. Long non-coding RNA (lncRNA) plays an important role in various pathophysiological processes. The P2X7 receptor is responsible for triggering inflammatory responses, such as pyroptosis, linked to pain and depression. The aim of this study was to investigate the effect of lncRNA MSTRG.81401 on hippocampal pyroptosis induced by the P2X7 receptor in diabetic rats with DNP combined with MDD (DNP + MDD)...
January 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38255975/the-role-of-microrna-long-non-coding-rna-and-circular-rna-in-the-pathogenesis-of-polycystic-ovary-syndrome-a-literature-review
#22
REVIEW
Jenan Sh Nasser, Noor Altahoo, Sayed Almosawi, Abrar Alhermi, Alexandra E Butler
Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disease in females of reproductive age, affecting 4-20% of pre-menopausal women worldwide. MicroRNAs (miRNAs) are endogenous, single-stranded, non-coding, regulatory ribonucleic acid molecules found in eukaryotic cells. Abnormal miRNA expression has been associated with several diseases and could possibly explain their underlying pathophysiology. MiRNAs have been extensively studied for their potential diagnostic, prognostic, and therapeutic uses in many diseases, such as type 2 diabetes, obesity, cardiovascular disease, PCOS, and endometriosis...
January 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38247810/the-genetic-aspects-of-periodontitis-pathogenesis-and-the-regenerative-properties-of-stem-cells
#23
REVIEW
Klaudia Ustianowska, Łukasz Ustianowski, Estera Bakinowska, Kajetan Kiełbowski, Joanna Szostak, Martyna Murawka, Bartosz Szostak, Andrzej Pawlik
Periodontitis (PD) is a prevalent and chronic inflammatory disease with a complex pathogenesis, and it is associated with the presence of specific pathogens, such as Porphyromonas gingivalis . Dysbiosis and dysregulated immune responses ultimately lead to chronic inflammation as well as tooth and alveolar bone loss. Multiple studies have demonstrated that genetic polymorphisms may increase the susceptibility to PD. Furthermore, gene expression is modulated by various epigenetic mechanisms, such as DNA methylation, histone modifications, or the activity of non-coding RNA...
January 9, 2024: Cells
https://read.qxmd.com/read/38234617/coptisine-prevents-angiotensin-ii%C3%A2-induced-endothelial-cell-injury-and-senescence-via-the-lncrna-snhg12-mir%C3%A2-603-nampt-pathway
#24
JOURNAL ARTICLE
Jing Meng, Xiaoying Song, Xinyue Xing, Jingyi Chen, Danfei Lou
Atherosclerosis (AS) is a major health problem and targeting the associated molecular pathways is critical for developing therapies. The present study investigated the effect of coptisine on human umbilical vein endothelial cells (HUVECs) in response to angiotensin II (Ang II) induction by focusing on cellular senescence, apoptosis and inflammation. HUVECs were treated with different Ang II concentrations and long non-coding RNA small nucleolar RNA host gene 12 (SNHG12), microRNA (miRNA/miR)-603 and nicotinamide phosphoribosyltransferase (NAMPT) expressions were assessed...
February 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38232183/lncrna-neat1-aggravates-human-microvascular-endothelial-cell-injury-by-inhibiting-the-apelin-nrf2-ho-1-signalling-pathway-in-type-2-diabetes-mellitus-with-obstructive-sleep-apnoea
#25
JOURNAL ARTICLE
Kai Chen, Baiqing Ou, Quan Huang, Daqing Deng, Yi Xiang, Fang Hu
Long noncoding RNAs (lncRNAs) regulate the progression of type 2 diabetes mellitus complicated with obstructive sleep apnoea (T2DM-OSA). However, the role of the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) in T2DM-OSA remains unknown. This study aimed to reveal the function of NEAT1 in T2DM-OSA and the underlying mechanism. KKAy mice were exposed to intermittent hypoxia (IH) or intermittent normoxia to generate a T2DM-OSA mouse model. HMEC-1 cells were treated with high glucose (HG) and IH to construct a T2DM-OSA cell model...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/38229193/transcriptomic-profiling-of-long-non-coding-rnas-and-messenger-rnas-in-the-liver-of-mice-during-toxoplasma-gondii-infection
#26
JOURNAL ARTICLE
Yang Zou, Xing Yang, Chao Chen, He Ma, Hong-Wei Cao, Jing Jiang, Xin-Yu Wei, Xiao-Xuan Zhang
BACKGROUND: Toxoplasma gondii is an intracellular protozoan parasite that can infect a wide range of warm-blooded animals, including humans. It poses significant health risks, particularly in immunocompromised individuals and during pregnancy, leading to severe disease manifestations. The liver, being a crucial organ involved in immune response and metabolic regulation, plays a critical role in the host's defense against T. gondii infection. METHODS: In this study, we utilized RNA sequencing to investigate the expression profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in the liver of mice infected with T...
January 16, 2024: Parasites & Vectors
https://read.qxmd.com/read/38223328/triptolide-alleviates-the-development-of-inflammation-in-ankylosing-spondylitis-via-the-nonhsat227927-1-jak2-stat3-pathway
#27
JOURNAL ARTICLE
Xiang Ding, Jian Liu, Yanqiu Sun, Xiaolu Chen
Ankylosing spondylitis (AS) is a chronic inflammatory disease that can destroy the affected joints. Triptolide (TPL), a key active ingredient of the traditional Chinese medicine Tripterygium wilfordii exhibits promising efficacy in rheumatic immune disease with its anti-inflammatory effects. The present study aimed to elucidate the mechanism of TPL in treatment of AS by regulating the long non-coding RNA (lncRNA) NONHSAT227927.1. The role and underlying mechanisms of TPL in the development of inflammation in AS were assessed...
January 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38212456/knockdown-of-neat1-prevents-post-stroke-lipid-droplet-agglomeration-in-microglia-by-regulating-autophagy
#28
JOURNAL ARTICLE
Yongli Pan, Wenqiang Xin, Wei Wei, Lars Tatenhorst, Irina Graf, Aurel Popa-Wagner, Stefan T Gerner, Sabine E Huber, Ertugrul Kilic, Dirk M Hermann, Mathias Bähr, Hagen B Huttner, Thorsten R Doeppner
BACKGROUND: Lipid droplets (LD), lipid-storing organelles containing neutral lipids like glycerolipids and cholesterol, are increasingly accepted as hallmarks of inflammation. The nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA with over 200 nucleotides, exerts an indispensable impact on regulating both LD agglomeration and autophagy in multiple neurological disorders. However, knowledge as to how NEAT1 modulates the formation of LD and associated signaling pathways is limited...
January 12, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38197962/expression-profiles-of-the-lncrna-antisense-gas5-as1-in-colon-biopsies-from-pediatric-inflammatory-bowel-disease-patients-and-its-role-in-regulating-sense-transcript-gas5
#29
JOURNAL ARTICLE
Debora Curci, Martina Franzin, Giulia Zudeh, Matteo Bramuzzo, Sara Lega, Giuliana Decorti, Gabriele Stocco, Marianna Lucafò
The long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) level was demonstrated as involved in pediatric inflammatory bowel disease (IBD) pathogenesis. Since its antisense transcript GAS5-AS1 has never been investigated in IBD, this study aims to detect whether GAS5-AS1 and GAS5 levels are related to IBD clinical parameters and investigate their correlation in vitro. Twenty-six IBD pediatric patients were enrolled; paired inflamed and non-inflamed intestinal biopsies were collected. We evaluated GAS5 and GAS5-AS1 levels by real-time PCR...
January 10, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38190023/integrative-analysis-of-the-age-related-dysregulated-genes-reveals-an-inflammation-and-immunity-associated-regulatory-network-in-alzheimer-s-disease
#30
JOURNAL ARTICLE
Zhuoze Wu, Lei Dong, Zhixiao Tian, Chenhui Yu, Qingrong Shu, Wei Chen, Hao Li
Alzheimer's disease (AD) is a neurodegenerative disease with a long incubation period. While extensive research has led to the construction of long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) regulatory networks, which primarily derived from differential analyses between clinical AD patients and control individuals or mice, there remains a critical knowledge gap pertaining to the dynamic alterations in transcript expression profiles that occur with age, spanning from the pre-symptomatic stage to the onset of AD...
January 8, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38172847/analysis-of-differentially-expressed-genes-in-torn-rotator-cuff-tendon-tissues-in-diabetic-patients-through-rna-sequencing
#31
JOURNAL ARTICLE
Ziyang Yuan, Xu Zhu, Yike Dai, Lin Shi, Ziyang Feng, Zhiyao Li, Naicheng Diao, Ai Guo, Heyong Yin, Lifeng Ma
BACKGROUND: Rotator cuff tears (RCT) is a common musculoskeletal disorder in the shoulder which cause pain and functional disability. Diabetes mellitus (DM) is characterized by impaired ability of producing or responding to insulin and has been reported to act as a risk factor of the progression of rotator cuff tendinopathy and tear. Long non-coding RNAs (lncRNAs) are involved in the development of various diseases, but little is known about their potential roles involved in RCT of diabetic patients...
January 3, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38167080/diagnostic-and-prognostic-potential-of-long-non-coding-rna-norad-in-patients-with-acute-deep-vein-thrombosis-and-its-role-in-endothelial-cell-function
#32
JOURNAL ARTICLE
Kun Zhou, Na Li, Jia Qi, Pingping Tu, Yan Yang, Hui Duan
BACKGROUND: Deep venous thrombosis (DVT) is the common clinical cardiovascular disease, and easily develops into post-thrombotic syndrome (PTS). The study aimed to examine the clinical value of long non-coding RNA NORAD gene in the development of DVT and PTS. In vitro, the underlying mechanism was explored. METHODS: Serum levels of lncRNA NORAD gene in 85 DVT cases and 85 healthy individuals were tested. The role of lncRNA NORAD gene in human umbilical vein endothelial cells (HUVECs) proliferation, migration and inflammation was examined...
January 2, 2024: Thrombosis Journal
https://read.qxmd.com/read/38160539/m2-macrophage-exosome-derived-lncrna-ak083884-protects-mice-from-cvb3-induced-viral-myocarditis-through-regulating-pkm2-hif-1%C3%AE-axis-mediated-metabolic-reprogramming-of-macrophages
#33
JOURNAL ARTICLE
Yingying Zhang, Liangyu Zhu, Xueqin Li, Chang Ge, Weiya Pei, Mengying Zhang, Min Zhong, Xiaolong Zhu, Kun Lv
Viral myocarditis (VM) is a clinically common inflammatory disease. Accumulating literature has indicated that M2 macrophages protect mice from Coxsackievirus B3 (CVB3)-induced VM. However, mechanisms that underlie M2 macrophages alleviating myocardial inflammation remain largely undefined. We found that M2 macrophage-derived exosomes (M2-Exo) can effectively attenuate VM. The long non-coding RNA (lncRNA) AK083884 in M2-Exo was found to be involved in the regulation of macrophage polarization by exosome lncRNA sequencing combined with in vitro functional assays...
December 28, 2023: Redox Biology
https://read.qxmd.com/read/38148128/long-non-coding-rna-meg3-silencing-weakens-high-glucose-induced-mesangial-cell-injury-by-decreasing-lin28b-expression-by-sponging-and-sequestering-mir-23c
#34
JOURNAL ARTICLE
Lu Rong, Huanzhou Xue, Jianwei Hao, Jianjun Liu, Hao Xu
BACKGROUND: Diabetic nephropathy (DN) is a common kidney disease in diabetic patients. Long non-coding RNA maternally expressed gene 3 (MEG3) and microRNA (miR)-23c are reported to be implicated in DN development. Nevertheless, it is unclear that the molecular mechanism between MEG3 and miR-23c in DN remains unclear. METHODS: Human mesangial cells (HMCs) were treated with high glucose (HG) to simulate the DN status in vitro. Expression of MEG3 and miR-23c was measured...
December 11, 2023: Kidney Research and Clinical Practice
https://read.qxmd.com/read/38139276/ager-1-long-non-coding-rna-levels-correlate-with-the-expression-of-the-advanced-glycosylation-end-product-receptor-a-regulator-of-the-inflammatory-response-in-visceral-adipose-tissue-of-women-with-obesity-and-type-2-diabetes-mellitus
#35
JOURNAL ARTICLE
Klaudia Gutowska, Krzysztof Koźniewski, Michał Wąsowski, Marta Izabela Jonas, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Artur Binda, Paweł Jaworski, Wiesław Tarnowski, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka, Krzysztof Czajkowski, Alina Kuryłowicz
The advanced glycosylation end-product receptor (AGER) is involved in the development of metabolic inflammation and related complications in type 2 diabetes mellitus (T2DM). Tissue expression of the AGER gene ( AGER ) is regulated by epigenetic mediators, including a long non-coding RNA AGER-1 (lncAGER-1). This study aimed to investigate whether human obesity and T2DM are associated with an altered expression of AGER and lncAGER-1 in adipose tissue and, if so, whether these changes affect the local inflammatory milieu...
December 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38133209/regulation-of-macrophage-polarization-in-allergy-by-noncoding-rnas
#36
REVIEW
Osamu Ishibashi, Stefan A Muljo, Zohirul Islam
Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such as peanuts, plant pollen, fungal spores, and the feces and debris of mites and insects. Macrophages are myeloid immune cells with phagocytic abilities that process exogenous and endogenous antigens. Upon activation, they can produce effector molecules such as cytokines as well as anti-inflammatory molecules. The dysregulation of macrophage function can lead to excessive type 1 inflammation as well as type 2 inflammation, which includes allergic reactions...
December 11, 2023: Non-Coding RNA
https://read.qxmd.com/read/38127070/the-lncrna-malat1-inhibits-mir-15-16-to-enhance-cytotoxic-t-cell-activation-and-memory-cell-formation
#37
JOURNAL ARTICLE
Benjamin D Wheeler, John D Gagnon, Wandi S Zhu, Priscila Muñoz-Sandoval, Simon K Wong, Dimitre S Simeonov, Zhongmei Li, Rachel DeBarge, Matthew H Spitzer, Alexander Marson, K Mark Ansel
Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers. Through biochemical analysis of RNA:protein interactions, we uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) and the microRNA family miR-15/16. miR-15/16 is a widely and highly expressed tumor suppressor miRNA family important for cell proliferation and survival...
December 21, 2023: ELife
https://read.qxmd.com/read/38114929/long-non-coding-rna-snhg4-aggravates-cigarette-smoke-induced-copd-by-regulating-mir-144-3p-ezh2-axis
#38
JOURNAL ARTICLE
Benyan Song, Yusi Chen
OBJECTIVE: The purpose of this study was to explore the expression level of SNHG4 in patients with COPD and its diagnostic value in COPD, to probe the biological function of SNHG4 in COPD at the cellular level, and to reveal the interaction between SNHG4 and miR-144-3p/EZH2 axis. METHODS: The serum levels of SNHG4, miR-144-3p and EZH2 in healthy people and patients with COPD were detected by RT-qPCR. The diagnostic value of SNHG4 in COPD was evaluated by ROC curve...
December 19, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/38085149/expression-analysis-of-long-noncoding-rna-malat1-and-interleukin-6-in-inflammatory-bowel-disease-patients
#39
JOURNAL ARTICLE
Mohsen Nemati Bajestan, Moein Piroozkhah, Vahid Chaleshi, Naser Elmi Ghiasi, Negar Jamshidi, Reza Mirfakhraie, Hedieh Balaii, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Zahra Salehi, Ehsan Nazemalhosseini Mojarad
 Inflammatory bowel disease (IBD) manifests as chronic inflammation within the gastrointestinal tract. The study focuses on a long noncoding RNA (lncRNA) known as Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). MALAT1's misregulation has been linked with various autoimmune diseases and regulates proinflammatory cytokines. The role of IL6 in immune-triggered conditions, including IBD, is another focal point. In this research, the expression of MALAT1 and IL6 in IBD patients was meticulously analyzed to uncover potential interactions...
October 29, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38076153/lncrna-gas5-downregulates-nlrp3-inflammasome-activation-mediated-pyroptosis-in-sepsis-induced-myocardial-injury-by-targeting-sirt3-ampk%C3%AE
#40
JOURNAL ARTICLE
Minghao Luo, Yuce Peng, Dingyi Lv, Yuzhou Xue, Longxiang Huang, Yu Hu, Wenyan Zhu, Suxin Luo, Jian Shen, Xiang Li
An increasing body of studies has demonstrated the significance of long non-coding RNA (lncRNA) growth arrest specific 5 (GAS5) in inflammation and myocardial injury in septic shock. This research aims to determine whether GAS5 contributes to the pathological development of sepsis-induced cardiac damage and NLRP3 inflammasome-mediated myocardial cell pyroptosis. Cecal ligation and puncture (CLP) surgery was used to cause septic shock in C57BL/6 wild-type mice. After CLP, inflammatory, pyroptosis parameters of myocardial tissue, survival rate, and Murine Sepsis Score (MSS) were assessed to evaluate the involvement of GAS5 in the mouse myocardial depression...
December 2023: Heliyon
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