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long non-coding RNA inflammation

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https://www.readbyqxmd.com/read/29662883/long-non-coding-rnas-in-vascular-inflammation
#1
Stefan Haemmig, Viorel Simion, Mark W Feinberg
Less than 2% of the genome encodes for proteins. Accumulating studies have revealed a diverse set of RNAs derived from the non-coding genome. Among them, long non-coding RNAs (lncRNAs) have garnered widespread attention over recent years as emerging regulators of diverse biological processes including in cardiovascular disease (CVD). However, our knowledge of their mechanisms by which they control CVD-related gene expression and cell signaling pathways is still limited. Furthermore, only a handful of lncRNAs has been functionally evaluated in the context of vascular inflammation, an important process that underlies both acute and chronic disease states...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29621481/in-inflamed-intestinal-tissues-and-epithelial-cells-interleukin-22-signaling-increases-expression-of-h19-long-noncoding-rna-which-promotes-mucosal-regeneration
#2
Hua Geng, Heng-Fu Bu, Fangyi Liu, Longtao Wu, Karl Pfeifer, Pauline M Chou, Xiao Wang, Jiaren Sun, Lu Lu, Ashutosh Pandey, Marisa S Bartolomei, Isabelle G De Plaen, Peng Wang, Jindan Yu, Jiaming Qian, Xiao-Di Tan
BACKGROUND & AIMS: Inflammation affects regeneration of the intestinal epithelia; long non-coding RNAs (lncRNAs) regulate cell functions such as proliferation, differentiation, and migration. We investigated the mechanisms by which the lncRNA H19, imprinted maternally expressed transcript (H19) regulates regeneration of intestinal epithelium using cell cultures and mouse models of inflammation. METHODS: We performed RNA-seq transcriptome analyses of intestinal tissues from mice with LPS-induced sepsis to identify lncRNAs associated with inflammation; findings were confirmed by quantitative real-time PCR and in situ hybridization analyses of intestinal tissues from mice with sepsis or dextran sulfate sodium (DSS)-induced mucosal wound healing and patients with ulcerative colitis, compared to healthy individuals (controls)...
April 2, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29581742/methylene-blue-relieves-the-development-of-osteoarthritis-by-upregulating-lncrna-meg3
#3
Xinyi Li, Chaoliang Tang, Jin Wang, Peipei Guo, Chengyao Wang, Yanlin Wang, Zongze Zhang, Huisheng Wu
Methylene blue (MB) is a long-term inhibitor of peripheral nerve axons, thereby alleviating or permanently eliminating pain. However, it remains unknown whether MB is safe and effective method of treating osteoarthritis (OA). MB was injected into the knee joints of rabbits and they were monitored for any histological structural changes. The results revealed no evident changes in the histological structure of the normal knee joint following injection of 1 mg/kg MB at 1, 4, 8 and 24 weeks post-injection. Compared with the vehicle control, MB treatment significantly enhanced the weight distribution and significantly decreased the swelling ratio of the rabbits...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29551552/non-coding-rna-regulation-of-endothelial-and-macrophage-functions-during-atherosclerosis
#4
REVIEW
Binod Aryal, Yajaira Suárez
The endothelial lining can be viewed as the first line of defense against risk factors of vascular disease. Endothelial dysfunction is regarded as an initial event for atherogenesis since defects in vascular integrity and homeostasis are responsible for lipid infiltration and recruitment of monocytes into the vessel wall. Monocytes-turned-macrophages, which possess astounding inflammatory plasticity, perpetuate chronic inflammation and growth of atherosclerotic plaques and, are therefore central for the pathogenesis of atherosclerosis...
March 15, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29518613/long-non-coding-rna-tug1-inhibits-apoptosis-and-inflammatory-response-in-lps-treated-h9c2-cells-by-down-regulation-of-mir-29b
#5
Haifang Zhang, Hui Li, Ang Ge, Enyu Guo, Shuxia Liu, Lijuan Zhang
OBJECTIVE: Myocarditis is an important cause for cardiovascular morbidity and mortality in children and adults. The lncRNA taurine up-regulated gene 1 (TUG1) plays important roles in cell apoptosis and inflammation in tumor and liver injury. The present study aimed to investigate the role of TUG1 in LPS-injured H9c2 cells and explore the underlying molecular mechanism. METHODS: H9c2 cells were stimulated with LPS to induce inflammatory injury. The expression of TUG1 was altered by transient transfections...
March 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29467431/hypoxia-induced-long-non-coding-rna-malat1-is-dispensable-for-renal-ischemia-reperfusion-injury
#6
Malte Kölling, Celina Genschel, Tamas Kaucsar, Anika Hübner, Song Rong, Roland Schmitt, Inga Sörensen-Zender, George Haddad, Andreas Kistler, Harald Seeger, Jan T Kielstein, Danilo Fliser, Hermann Haller, Rudolf Wüthrich, Martin Zörnig, Thomas Thum, Johan Lorenzen
Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Non-coding RNAs are crucially involved in its pathophysiology. We identified hypoxia-induced long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) to be upregulated in renal I/R injury. We here elucidated the functional role of Malat1 in vitro and its potential contribution to kidney injury in vivo. Malat1 was upregulated in kidney biopsies and plasma of patients with AKI, in murine hypoxic kidney tissue as well as in cultured and ex vivo sorted hypoxic endothelial cells and tubular epithelial cells...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451908/cas9-mediated-excision-of-proximal-dnasei-h3k4me3-signatures-confers-robust-silencing-of-microrna-and-long-non-coding-rna-genes
#7
Harshavardhan Janga, Marina Aznaourova, Fabian Boldt, Katrin Damm, Arnold Grünweller, Leon N Schulte
CRISPR/Cas9-based approaches have greatly facilitated targeted genomic deletions. Contrary to coding genes however, which can be functionally knocked out by frame-shift mutagenesis, non-coding RNA (ncRNA) gene knockouts have remained challenging. Here we present a universal ncRNA knockout approach guided by epigenetic hallmarks, which enables robust gene silencing even in provisionally annotated gene loci. We build on previous work reporting the presence of overlapping histone H3 lysine 4 tri-methylation (H3K4me3) and DNaseI hypersensitivity sites around the transcriptional start sites of most genes...
2018: PloS One
https://www.readbyqxmd.com/read/29449542/long-non-coding-rnas-in-ischemic-stroke
#8
REVIEW
Mei-Hua Bao, Vivian Szeto, Burton B Yang, Shu-Zhen Zhu, Hong-Shuo Sun, Zhong-Ping Feng
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29436679/long-non%C3%A2-coding-rna-bc168687-small-interfering-rna-reduces-high-glucose-and-high-free-fatty-acid%C3%A2-induced-expression-of-p2x7-receptors-in-satellite-glial-cells
#9
Cheng-Long Liu, Ze-Yu Deng, Er-Rong Du, Chang-Shui Xu
Purinergic signaling contributes to inflammatory and immune responses. The activation of the P2X purinoceptor 7 (P2X7) in satellite glial cells (SGCs) may be an essential component in the promotion of inflammation and neuropathic pain. Long non‑coding RNAs (lncRNAs) are involved in multiple physiological and pathological processes. The aim of the present study was to investigate the effects of a small interfering RNA for the lncRNA BC168687 on SGC P2X7 expression in a high glucose and high free fatty acids (HGHF) environment...
February 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436619/a-six-long-non-coding-rna-signature-predicts-prognosis-in-melanoma-patients
#10
Shuocheng Yang, Jianguo Xu, Xuan Zeng
The aim of this study was to identify long non-coding RNAs (lncRNAs) which may prove useful for risk-classifying patients with melanoma. For this purpose, based on a dataset from The Cancer Genome Atlas (TCGA), we selected and analyzed samples from melanoma stages I, II, III and IV, from which differentially expressed lncRNAs were identified. The lncRNAs were classified using two-way hierarchical clustering analysis and analysis of support vector machine (SVM), followed by Kaplan-Meier survival analysis. The prognostic capacity of the signature was verified on an independent dataset...
February 7, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29383188/microarray-analysis-of-lung-long-non-coding-rnas-in-cigarette-smoke-exposed-mouse-model
#11
Hao Wang, Lei Chen, Diandian Li, Ni Zeng, Yanqiu Wu, Tao Wang, Yongchun Shen, Dan Xu, Fuqiang Wen
Several studies have demonstrated the function of long nonâ€'coding RNAs (lncRNAs) in various biological processes, yet their role underlying the susceptibility to cigarette smoke (CS)-induced airway inflammation remains limited. In the present study, we aimed to profile the expression of lncRNAs and mRNAs in CS-exposed mice. C57BL/6 mice were assigned into a single cigarette-smoking machine with or without CS exposure for 4 weeks, followed by lung tissue harvest and RNA isolation. Microarray analysis identified 108 lncRNAs and 119 mRNAs with differential expression levels in CS-exposed mouse lung tissue compared with those in control mice...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29383134/long-non-coding-rna-deep-sequencing-reveals-the-role-of-macrophage-in-liver-disorders
#12
Zhang Lin, Hao Changfu, Zhao Fengling, Guo Wei, Bao Lei, Li Yiping, Zhang Miao, Yue Zhongzheng, Zhao Youliang, Duan Shuyin, Yao Wu
Liver disorders such as hepatitis, cirrhosis and hepatocellular carcinoma are a series of the most life threatening diseases along with extensive inflammatory cellular infiltrations. Macrophage has been proved to be key regulators and initiators of inflammation, and long non-coding RNAs (lncRNAs) are recommended to play critical roles in the occurrence and development of a variety of diseases. To uncover the role of macrophage in liver disorders via lncRNA sequencing method, we first applied a lncRNA classification pipeline to identify 1247 lncRNAs represented on the Affymetrix Mouse Genome 430/430A 2...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29230038/the-lps-inducible-lncrna-mirt2-is-a-negative-regulator-of-inflammation
#13
Meng Du, Lin Yuan, Xin Tan, Dandan Huang, Xiaojing Wang, Zhe Zheng, Xiaoxiang Mao, Xiangrao Li, Liu Yang, Kun Huang, Fengxiao Zhang, Yan Wang, Xi Luo, Dan Huang, Kai Huang
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRR) with a crucial function in innate immune responses. Activation of TLR4 signaling at the plasma membrane by lipopolysaccharide (LPS) stimulates proinflammatory signaling pathways dependent on the E3 ubiquitin ligase TRAF6. Here we show the LPS-induced long non-coding RNA (lncRNA) Mirt2 functions as a checkpoint to prevent aberrant activation of inflammation, and is a potential regulator of macrophage polarization. Mirt2 associates with, and attenuates Lys63 (K63)-linked ubiquitination of, TRAF6, thus inhibiting activation of NF-κB and MAPK pathways and limiting production of proinflammatory cytokines...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29196750/a-novel-y-specific-long-non-coding-rna-associated-with-cellular-lipid-accumulation-in-hepg2-cells-and-atherosclerosis-related-genes
#14
Elsa Molina, Guat S Chew, Stephen A Myers, Elyse M Clarence, James M Eales, Maciej Tomaszewski, Fadi J Charchar
There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide. However, the exact mechanism and potential genes implicated are still unidentified. To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link between these new regulatory RNA molecules and hepatic function in men has not been investigated...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29172088/silencing-of-h19-inhibits-the-adipogenesis-and-inflammation-response-in-ox-ldl-treated-raw264-7-cells-by-up-regulating-mir-130b
#15
Yong Han, Jie Ma, Junping Wang, Liping Wang
Atherosclerosis (AS) is the main cause of cardiovascular diseases (CADs). Lipid accumulation and inflammatory response in macrophages are two key factors in the pathogenesis of AS. In this study, we aimed to explore the regulating role of long non-coding RNA (LncRNA)-H19 in oxygenized low density lipoprotein (ox-LDL)-treated Raw264.7 cells. Compared with the healthy control, a relatively higher level of H19 was detected in the blood samples from AS patients. Obviously up-regulated expression of TG (triglycerides)/TC (total cholesterol)/LDL-C (low density lipoprotein-cholesterol) and down-regulated level of HDL-C (high density lipoprotein-cholesterol) were detected in ox-LDL-treated Raw264...
January 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29075020/the-rbm14-coaa-interacting-long-intergenic-non-coding-rna-paral1-regulates-adipogenesis-and-coactivates-the-nuclear-receptor-ppar%C3%AE
#16
François F Firmin, Frederik Oger, Céline Gheeraert, Julie Dubois-Chevalier, Anne-Sophie Vercoutter-Edouart, Fawaz Alzaid, Claire Mazuy, Hélène Dehondt, Jeremy Alexandre, Bruno Derudas, Quentin Dhalluin, Maheul Ploton, Alexandre Berthier, Eloise Woitrain, Tony Lefebvre, Nicolas Venteclef, François Pattou, Bart Staels, Jérôme Eeckhoute, Philippe Lefebvre
Adipocyte differentiation and function relies on a network of transcription factors, which is disrupted in obesity-associated low grade, chronic inflammation leading to adipose tissue dysfunction. In this context, there is a need for a thorough understanding of the transcriptional regulatory network involved in adipose tissue pathophysiology. Recent advances in the functional annotation of the genome has highlighted the role of non-coding RNAs in cellular differentiation processes in coordination with transcription factors...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29033949/microarray-analysis-identifies-the-potential-role-of-long-non-coding-rna-in-regulating-neuroinflammation-during-japanese-encephalitis-virus-infection
#17
Yunchuan Li, Hao Zhang, Bibo Zhu, Usama Ashraf, Zheng Chen, Qiuping Xu, Dengyuan Zhou, Bohan Zheng, Yunfeng Song, Huanchun Chen, Jing Ye, Shengbo Cao
Japanese encephalitis virus (JEV) is the leading cause of epidemic encephalitis worldwide. JEV-induced neuroinflammation is characterized by profound neuronal cells damage accompanied by activation of glial cells. Albeit long non-coding RNAs (lncRNAs) have been emerged as important regulatory RNAs with profound effects on various biological processes, it is unknown how lncRNAs regulate JEV-induced inflammation. Here, using microarray approach, we identified 618 lncRNAs and 1,007 mRNAs differentially expressed in JEV-infected mice brain...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29032575/decreased-expression-of-ifng-as1-ifng-and-il-1b-inflammatory-genes-in-medicated-schizophrenia-and-bipolar-patients
#18
H Ghafelehbashi, M Pahlevan Kakhki, L Kular, S Moghbelinejad, S H Ghafelehbashi
Although aberrant expression of cytokines such as IL-1B and IFNG in blood from psychiatric patients supports a role of inflammation in the pathogenesis of the disease, little is known about mechanisms underlying their regulation. We aimed to evaluate the putative role of IFNG-AS1 long non-coding RNA (lncRNA) in controlling of IFNG locus in patients with schizophrenia (SZ) and bipolar (BP). We analysed the expression levels of IFNG-AS1 long non-coding RNA, and IFNG and IL-1B mRNAs in blood cells from 27 SZ- and 30 BP-medicated patients and in 32 healthy controls...
December 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29030863/hotair-but-not-anril-long-non-coding-rna-contributes-to-the-pathogenesis-of-multiple-sclerosis
#19
Majid Pahlevan Kakhki, Abbas Nikravesh, Zeinab Shirvani Farsani, Mohammad Ali Sahraian, Mehrdad Behmanesh
Different studies have revealed that dysregulation in gene expression is one of the main aspects of multiple sclerosis (MS) pathogenesis. Although the molecular pathways underlying the immunomodulatory role of vitamin D (VD) in MS is not completely elucidated, VD has more recently become a topic of interest in immune regulation and is widely administrated to MS patients as an immunomodulatory supplement. Long non-coding RNAs (lncRNAs) are known to play important roles in regulation of gene expression via different mechanisms...
October 14, 2017: Immunology
https://www.readbyqxmd.com/read/28993196/long-non-coding-rna-expression-profiles-in-different-severity-ev71-infected-hand-foot-and-mouth-disease-patients
#20
Jun Meng, Zhenyu Yao, Yaqing He, Renli Zhang, Hong Yang, Xiangjie Yao, Long Chen, Hailong Zhang, Jinquan Cheng
Enterovirus 71 (EV71) is associated with the severe hand foot and mouth disease (HFMD) outcomes, however the host-virus interaction mechanism and the pathogenesis remain poorly understood. Long non-coding RNAs (lncRNAs) are involved in variety physiological and pathological processes, but the functions of lncRNAs in EV71 infection remain elusive. Here we profiled the expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) from EV71-infected mild patients, severe patients as well as the healthy controls, and identified 8541 lncRNAs were differentially expressed...
December 2, 2017: Biochemical and Biophysical Research Communications
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