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long non-coding RNA inflammation

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https://www.readbyqxmd.com/read/28145813/alteration-in-long-non-coding-rna-expression-after-traumatic-brain-injury-in-rats
#1
Chuan-Fang Wang, Cheng-Cheng Zhao, Wei-Ji Weng, Jin Lei, Yong Lin, Qing Mao, Guo-Yi Gao, Jun-Feng Feng, Ji-Yao Jiang
Traumatic brain injury (TBI) causes a primary insult and initiates a secondary injury cascade. The mechanisms underlying the secondary injury are multifactorial and may include the aberrant expression of long non-coding RNA (lncRNA) post-TBI. Here, lncRNA microarray analysis was performed to profile the altered lncRNAs in the rat hippocampus after TBI. A total of 271 lncRNA probe sets and 1046 mRNA probe sets were differentially expressed after TBI. Gene ontology analysis showed that the main components of the most significantly changed categories were inflammation, DNA transcription, apoptosis and necroptosis...
February 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28094339/massive-effect-on-lncrnas-in-human-monocytes-during-fungal-and-bacterial-infections-and-in-response-to-vitamins-a-and-d
#2
Konstantin Riege, Martin Hölzer, Tilman E Klassert, Emanuel Barth, Julia Bräuer, Maximilian Collatz, Franziska Hufsky, Nelly Mostajo, Magdalena Stock, Bertram Vogel, Hortense Slevogt, Manja Marz
Mycoses induced by C.albicans or A.fumigatus can cause important host damage either by deficient or exaggerated immune response. Regulation of chemokine and cytokine signaling plays a crucial role for an adequate inflammation, which can be modulated by vitamins A and D. Non-coding RNAs (ncRNAs) as transcription factors or cis-acting antisense RNAs are known to be involved in gene regulation. However, the processes during fungal infections and treatment with vitamins in terms of therapeutic impact are unknown...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073183/a-liver-specific-long-non-coding-rna-with-a-role-in-cell-viability-is-elevated-in-human-non-alcoholic-steatohepatitis
#3
Biljana Atanasovska, Sander S Rensen, Marijke R van der Sijde, Glenn Marsman, Vinod Kumar, Iris Jonkers, Sebo Withoff, Ronit Shiri-Sverdlov, Jan Willem M Greve, Klaas Nico Faber, Han Moshage, Cisca Wijmenga, Bart van de Sluis, Marten H Hofker, Jingyuan Fu
: Hepatocyte apoptosis in non-alcoholic steatohepatitis (NASH) can lead to fibrosis and cirrhosis, which permanently damage the liver. Understanding the regulation of hepatocyte apoptosis is therefore important to identify therapeutic targets that may prevent the progression of NASH to fibrosis. Recently, increasing evidence has shown that lncRNAs are involved in various biological processes and that their dysregulation underlies a number of complex human diseases. By performing gene expression profiling of 4,383 lncRNAs in 82 liver samples from individuals with NASH (n=48), simple steatosis but no NASH (n=11) and healthy controls (n=23), we discovered a liver-specific lncRNA (RP11-484N16...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28003323/precise-long-non-coding-rna-modulation-in-visual-maintenance-and-impairment
#4
REVIEW
Peixing Wan, Wenru Su, Yehong Zhuo
Long non-coding RNAs (lncRNAs) are remarkably powerful, flexible and pervasive cellular regulators. With the help of cheaper RNA-seq, high-throughput screening of lncRNAs has become widely applied and has identified large numbers of specific lncRNAs in various physiological or pathological processes. Vision is known to be a complex and vital perception that comprises 80% of the sensory information we receive. A consensus has been reached that normal visual maintenance and impairment are primarily driven by gene regulation...
December 21, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27991686/co-expression-changes-of-lncrnas-and-mrnas-in-the-cervical-sympathetic-ganglia-in-diabetic-cardiac-autonomic-neuropathic-rats
#5
Guilin Li, Xuan Sheng, Yurong Xu, Huaide Jiang, Chaoran Zheng, Jingjing Guo, Shanshan Sun, Zhihua Yi, Shulan Qin, Shuangmei Liu, Yun Gao, Chunping Zhang, Hong Xu, Bing Wu, Lifang Zou, Shangdong Liang, Gaochun Zhu
Cardiac autonomic neuropathy in Type 2 diabetes (T2D) is often a devastating complication. Long non-coding RNAs (lncRNAs) have important effects on both normal development and disease pathogenesis. In this study, we explored the expression profiles of some lncRNAs involved in inflammation which may be co-expressed with messenger RNA (mRNA) in superior cervical and stellate ganglia after type 2 diabetic injuries. Total RNA isolated from 10 pairs of superior cervical and stellate ganglia in diabetic and normal male rats was hybridized to lncRNA arrays for detections...
December 19, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27915042/non-coding-rnas-and-berberine-a-new-mechanism-of-its-anti-diabetic-activities
#6
REVIEW
Wenguang Chang
Type 2 Diabetes (T2D) is a metabolic disease with high mortality and morbidity. Non-coding RNAs, including small and long non-coding RNAs, are a novel class of functional RNA molecules that regulate multiple biological functions through diverse mechanisms. Studies in the last decade have demonstrated that non-coding RNAs may represent compelling therapeutic targets and play important roles in regulating the course of insulin resistance and T2D. Berberine, a plant-based alkaloid, has shown promise as an anti-hyperglycaemic, anti-hyperlipidaemic agent against T2D...
December 1, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27902487/identification-of-laryngeal-cancer-prognostic-biomarkers-using-an-inflammatory-gene-related-competitive-endogenous-rna-network
#7
Qun He, Linli Tian, Hao Jiang, Jiarui Zhang, Qiang Li, Yanan Sun, Jiannan Zhao, Huijun Li, Ming Liu
Competitive endogenous RNAs (ceRNAs) act as molecular sponges for microRNAs (miRNAs), and are associated with tumorigenesis in various cancers, including laryngeal cancer (LC). In this work, we constructed an LC-specific inflammatory gene-related ceRNA network (IceNet). In IceNet, ceRNAs targeting inflammation-related genes tended to be network hubs. Additionally, the betweenness centralities of these hub ceRNAs were higher than those of the inflammation-related genes themselves, indicating that the hub ceRNAs in this study played critical roles in communication between IceNet molecules...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27878945/regulatory-non-coding-rnas-in-acute-myocardial-infarction
#8
REVIEW
Yuan Guo, Fei Luo, Qiong Liu, Danyan Xu
Acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that leads to high mortality and morbidity globally. Various therapeutic targets for AMI have been investigated in recent years, including the non-coding RNAs (ncRNAs). NcRNAs, a class of RNA molecules that typically do not code proteins, are divided into several subgroups. Among them, microRNAs (miRNAs) are widely studied for their modulation of several pathological aspects of AMI, including cardiomyocyte apoptosis, inflammation, angiogenesis and fibrosis...
November 23, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27809873/lncrnas-h19-and-hulc-activated-by-oxidative-stress-promote-cell-migration-and-invasion-in-cholangiocarcinoma-through-a-cerna-manner
#9
Wen-Tao Wang, Hua Ye, Pan-Pan Wei, Bo-Wei Han, Bo He, Zhen- Hua Chen, Yue-Qin Chen
BACKGROUND: Long non-coding RNAs (lncRNAs) are known to play important roles in different cell contexts, including cancers. However, little is known about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis, associated with chronic inflammation and damage to the biliary epithelium. The aim of the study is to identify if any lncRNA might associate with inflammation or oxidative stress in CCA and regulate the disease progression. METHODS: In this study, RNA-seqs datasets were used to identify aberrantly expressed lncRNAs...
November 3, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27797128/long-non-coding-rna-miat-knockdown-promotes-osteogenic-differentiation-of-human-adipose-derived-stem-cells
#10
Chanyuan Jin, Yunfei Zheng, Yiping Huang, Yunsong Liu, Lingfei Jia, Yongsheng Zhou
Recently, long non-coding RNAs (lncRNAs) have emerged as critical players in gene regulation for multiple biological processes. However, their roles and functions in human adipose-derived stem cells (hASCs) differentiation remain unclear. In the present study, we investigated the role of lncRNA myocardial infarction-associated transcript (MIAT) in the osteogenic differentiation of hASCs. We found that the expression of MIAT was downregulated in a time-dependent manner during hASCs osteoinduction. MIAT knockdown promoted osteogenic differentiation of hASCs both in vitro and in vivo...
January 2017: Cell Biology International
https://www.readbyqxmd.com/read/27793094/network-analysis-of-psoriasis-reveals-biological-pathways-and-roles-for-coding-and-long-non-coding-rnas
#11
Richard Ahn, Rashmi Gupta, Kevin Lai, Nitin Chopra, Sarah T Arron, Wilson Liao
BACKGROUND: Psoriasis is an immune-mediated, inflammatory disorder of the skin characterized by chronic inflammation and hyperproliferation of the epidermis. Differential expression analysis of microarray or RNA-seq data have shown that thousands of coding and non-coding genes are differentially expressed between psoriatic and healthy control skin. However, differential expression analysis may fail to detect perturbations in gene coexpression networks. Sensitive detection of such networks may provide additional insight into important disease-associated pathways...
October 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27607236/silencing-of-long-non-coding-rna-nonhsat009968-ameliorates-the-staphylococcal-protein-a-inhibited-osteogenic-differentiation-in-human-bone-mesenchymal-stem-cells
#12
Yi Cui, Sheng Lu, Hongbo Tan, Jun Li, Min Zhu, Yongqing Xu
BACKGROUND/AIMS: Osteomyelitis is defined as an inflammation of the bones and bone marrow. The inflammatory microenvironment attenuates the osteogenic differentiation capacity of stem cells and inhibits osteoblast-mediated bone formation, leading to net bone loss. However, the whole expression profile, function and side effect of long non-coding RNAs (lncRNAs) on osteogenic differentiation of stem cells in an inflammatory microenvironment of osteomyelitis are not known. METHODS: In the present study, human bone mesenchymal stem cells (hBMSCs) were treated with different concentrations of Staphylococcal protein A (SpA) to trigger an inflammatory microenvironment in vitro to partly duplicate the inflammatory microenvironment of osteomyelitis, which was confirmed using ELISA for detecting the inflammatory cytokines...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27525555/the-long-non-coding-rna-morrbid-regulates-bim-and-short-lived-myeloid-cell-lifespan
#13
Jonathan J Kotzin, Sean P Spencer, Sam J McCright, Dinesh B Uthaya Kumar, Magalie A Collet, Walter K Mowel, Ellen N Elliott, Asli Uyar, Michelle A Makiya, Margaret C Dunagin, Christian C D Harman, Anthony T Virtue, Stella Zhu, Will Bailis, Judith Stein, Cynthia Hughes, Arjun Raj, E John Wherry, Loyal A Goff, Amy D Klion, John L Rinn, Adam Williams, Richard A Flavell, Jorge Henao-Mejia
Neutrophils, eosinophils and 'classical' monocytes collectively account for about 70% of human blood leukocytes and are among the shortest-lived cells in the body. Precise regulation of the lifespan of these myeloid cells is critical to maintain protective immune responses and minimize the deleterious consequences of prolonged inflammation. However, how the lifespan of these cells is strictly controlled remains largely unknown. Here we identify a long non-coding RNA that we termed Morrbid, which tightly controls the survival of neutrophils, eosinophils and classical monocytes in response to pro-survival cytokines in mice...
September 8, 2016: Nature
https://www.readbyqxmd.com/read/27492330/a-long-noncoding-rna-signature-for-ulcerative-colitis-identifies-ifng-as1-as-an-enhancer-of-inflammation
#14
David Padua, Swapna Mahurkar-Joshi, Ivy Ka Man Law, Christos Polytarchou, John P Vu, Joseph R Pisegna, David Shih, Dimitrios Iliopoulos, Charalabos Pothoulakis
High-throughput technologies revealed new categories of genes, including the long noncoding RNAs (lncRNAs), involved in the pathogenesis of human disease; however, the role of lncRNAs in the ulcerative colitis (UC) has not been evaluated. Gene expression profiling was used to develop lncRNA signatures in UC samples. Jurkat T cells were activated by PMA/ionomycin subsequently interferon-γ (IFNG) and tumor necrosis factor (TNF)-α protein levels were assessed by ELISA. Anti-sense molecules were designed to block IFNG-AS1 expression...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27268316/long-noncoding-rnas-and-their-regulatory-network-potential-therapeutic-targets-for-adult-moyamoya-disease
#15
Faliang Gao, Lanbing Yu, Dong Zhang, Yan Zhang, Rong Wang, Jizong Zhao
OBJECTIVE: To investigate long noncoding ribonucleic acid (lncRNA) expression patterns in adult moyamoya disease (MMD) patients and explore their possible roles in the pathophysiology of MMD. METHODS: A healthy control group (n = 10) and an MMD group (n = 15) were evaluated. RNA was extracted from peripheral blood samples and hybridized to microarray to get lncRNA expression profiles. Then predicted lncRNA target genes were identified, and bioinformatics analysis was performed to investigate their molecular functions...
September 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26971344/microrna-27a-negatively-modulates-the-inflammatory-response-in-lipopolysaccharide-stimulated-microglia-by-targeting-tlr4-and-irak4
#16
Yan-Ni Lv, Ai-Jun Ou-Yang, Long-Sheng Fu
microRNA, a family of small non-coding RNA, plays significant roles in regulating gene expression, mainly via binding to the 3'-untranslated region of target genes. Although the role of miRNA in regulating neuroinflammation via the innate immune pathway has been studied, its role in the production of inflammatory mediators during microglial activation is poorly understood. In this study, we investigated the effect of miR-27a on lipopolysaccharide (LPS)-induced microglial inflammation. miR-27a expression was found to be rapidly decreased in microglia by real-time polymerase chain reaction (real-time PCR) after LPS stimulation...
March 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/26845358/long-noncoding-rna-meg3-is-involved-in-diabetes-mellitus-related-microvascular-dysfunction
#17
Gui-Zhen Qiu, Wei Tian, Hai-Tao Fu, Chao-Peng Li, Ban Liu
Microvascular dysfunction is an important characteristic of diabetic retinopathy. Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes. In this study, we investigated the role of lncRNA-MEG3 in diabetes-related microvascular dysfunction. We show that MEG3 expression level is significantly down-regulated in the retinas of STZ-induced diabetic mice, and endothelial cells upon high glucose and oxidative stress. MEG3 knockdown aggravates retinal vessel dysfunction in vivo, as shown by serious capillary degeneration, and increased microvascular leakage and inflammation...
February 26, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26838806/bcl2-is-a-critical-regulator-of-bile-acid-homeostasis-by-dictating-shp-and-lncrna-h19-function
#18
Yuxia Zhang, Chune Liu, Olivier Barbier, Rana Smalling, Hiroyuki Tsuchiya, Sangmin Lee, Don Delker, An Zou, Curt H Hagedorn, Li Wang
Bile acid (BA) metabolism is tightly controlled by nuclear receptor signaling to coordinate regulation of BA synthetic enzymes and transporters. Here we reveal a molecular cascade consisting of the antiapoptotic protein BCL2, nuclear receptor Shp, and long non-coding RNA (lncRNA) H19 to maintain BA homeostasis. Bcl2 was overexpressed in liver of C57BL/6J mice using adenovirus mediated gene delivery for two weeks. Hepatic overexpression of Bcl2 caused drastic accumulation of serum BA and bilirubin levels and dysregulated BA synthetic enzymes and transporters...
February 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26812074/long-non-coding-rna-dilc-regulates-liver-cancer-stem-cells-via-il-6-stat3-axis
#19
Xue Wang, Wen Sun, Weifeng Shen, Mingyang Xia, Cheng Chen, Daimin Xiang, Beifang Ning, Xiuliang Cui, Hengyu Li, Xiaofeng Li, Jin Ding, Hongyang Wang
BACKGROUND & AIMS: Emerging evidence has demonstrated the aberrant expression of long non-coding RNAs (lncRNAs) in various malignancies including HCC. However, the knowledge of cancer stem cell-related lncRNAs remains limited. METHODS: lnc-DILC (lncRNA downregulated in liver cancer stem cells (LCSCs)) was identified by microarray and validated by real-time PCR. The role of lnc-DILC in LCSCs was assessed both in vitro and in vivo. Pull down assay and oligoribonucleotides or oligodeoxynucleotides treatment were conducted to evaluate the interaction between lnc-DILC and interleukin-6 (IL-6) promoter...
June 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/26794462/tnf-%C3%AE-induces-vascular-endothelial-cells-apoptosis-through-overexpressing-pregnancy-induced-noncoding-rna-in-kawasaki-disease-model
#20
Chunming Jiang, Xiang Fang, Yanqiu Jiang, Fang Shen, Zhaoyang Hu, Xiaoli Li, Xianmei Huang
Kawasaki disease (KD) is an autoimmune disease in which the medium-sized blood vessels throughout the body become inflamed. The increased evidences showed that TNF-α was association with vascular inflammation in KD patients. However the detailed mechanism was still unclear. Recent studies indicated abnormal expressed long non-coding RNAs (LncRNAs) involved in many diseases. Thus the purpose of this study is to explore the role of lncRNAs in KD and find out the new target for KD treatment. In this study, firstly we verified the overexpressed TNF-α in KD patients, and found TNF-α was able to induce HUVECs apoptosis and inhibit HUVECs proliferation...
March 2016: International Journal of Biochemistry & Cell Biology
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