Kaiyuan Niu, Chengxin Zhang, Mei Yang, Eithne Margaret Maguire, Zhenning Shi, Shasha Sun, Jianping Wu, Chenxin Liu, Weiwei An, Xinxin Wang, Shan Gao, Shenglin Ge, Qingzhong Xiao
AIMS: Long non-coding RNA (LncRNA) small nucleolar RNA host gene 18 (SNHG18) has been widely implicated in cancers. However, little is known about its functional involvement in vascular diseases. Herein, we attempted to explore a role for SNHG18 in modulating vascular smooth muscle cell (VSMC) contractile phenotype and injury-induced neointima formation. METHODS AND RESULTS: Analysis of single cell RNA sequencing and transcriptomic datasets showed decreased levels of SNHG18 in injured and atherosclerotic murine and human arteries, which is positively associated with VSMC contractile genes...
March 18, 2024: Cardiovascular Research