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https://www.readbyqxmd.com/read/28260796/association-between-well-characterized-lung-cancer-lncrna-polymorphisms-and-platinum-based-chemotherapy-toxicity-in-chinese-patients-with-lung-cancer
#1
Wei-Jing Gong, Jing-Bo Peng, Ji-Ye Yin, Xiang-Ping Li, Wei Zheng, Ling Xiao, Li-Ming Tan, Di Xiao, Yi-Xin Chen, Xi Li, Hong-Hao Zhou, Zhao-Qian Liu
Platinum-based chemotherapy is the standard first-line treatment for most lung cancer patients. However, the toxicity induced by platinum-based chemotherapy greatly impedes its clinical use. Previous studies showed that long non-coding RNAs (lncRNAs) with over 200 nucleotides in length affect drug response and toxicity. In the present study, we investigated the association of well-characterized lung cancer lncRNA polymorphisms with platinum-based chemotherapy toxicity in Chinese patients with lung cancer. A total of 467 lung cancer patients treated with platinum-based chemotherapy for at least two cycles were recruited...
March 6, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28251886/highly-expressed-antisense-non-coding-rna-in-the-ink4-locus-promotes-5-growth-and-invasion-of-renal-clear-carcinoma-cells-via-the-%C3%AE-catenin-pathway
#2
Qingchun Li, Yuan Tian, Guangrui Hu, Yun Liang, Wei Bai, Hongjun Li
Long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) is involved in several human cancers.However, the role of ANRIL in renal cell carcinoma (RCC) remains unclear. This study was aimed to explore whether and how ANRIL affects the RCC progression. First of all, the expression of ANRIL in clinical tumor tissues and 4 kinds of RCC cell lines were evaluated. After transfection, the cell viability, colony number, apoptosis, migration and invasion were all assessed. Then, the expression of proteins related to apoptosis, epithelial to mesenchymal transition (EMT) and β-catenin signaling pathway were all assessed...
March 2, 2017: Oncology Research
https://www.readbyqxmd.com/read/28248879/a-three-long-noncoding-rna-signature-as-a-diagnostic-biomarker-for-differentiating-between-triple-negative-and-non-triple-negative-breast-cancers
#3
Man Liu, Lu-Qi Xing, Yi-Jing Liu
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive cancer with unfavorable outcome and it is useful to explore noninvasive biomarkers for its early diagnosis. Here, we identified differentially expressed long noncoding RNAs (lncRNAs) in blood samples of patients with TNBC to assess their diagnostic value. METHODS: Differential expression of lncRNAs in plasma of patients with TNBC (n = 25) and non-TNBC (NTNBC; n = 35) and in healthy controls was compared by microarray analysis and validated by real-time PCR...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28243616/data-on-genotypic-distribution-and-linkage-disequilibrium-of-several-anril-polymorphisms-in-hemodialysis-patients
#4
A Arbiol-Roca, A Padró-Miquel, M Hueso, E Navarro, P Alía-Ramos, M T González-Álvarez, I Rama, J Torras, J M Grinyó, J M Cruzado, N Lloberas
A long non-coding RNA called ANRIL located on chromosome 9p21.3 has been identified as a novel genetic factor associated with cardiovascular disease. Investigation of several single nucleotide polymorphisms (SNPs) of Noncoding Antisense RNA in the INK4 Locus (ANRIL) gene are of particular interest. This article reports data related to the research article entitled: "Association of ANRIL gene polymorphisms with major adverse cardiovascular events in hemodialysis patients" (Arbiol-Roca et al. [1]). Data presented show the genotypic distribution of four selected ANRIL SNPs: rs10757278, rs4977574, rs10757274 and rs6475606 in a cohort constituted by 284 hemodialysis patients...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28150872/polymorphism-in-anril-is-associated-with-relapse-in-patients-with-multiple-myeloma-after-autologous-stem-cell-transplant
#5
Ming J Poi, Junan Li, Douglas W Sborov, Zachary VanGundy, Yu Kyoung Cho, Misty Lamprecht, Flavia Pichiorri, Mitch A Phelps, Craig C Hofmeister
Multiple myeloma (MM) is a hematologic malignancy characterized by clonal proliferation of plasma cells and overproduction of monoclonal immunoglobins. Treatment with melphalan is currently standard of care for younger and fit patients when followed by hematopoietic stem cell transplantation (HSCT), and in transplant ineligible patients when used in combination regimens. It has been previously shown that changes in the p53 pathway are associated with melphalan efficacy, but the regulatory role of the p14ARF-MDM2-p53 axis has yet to be fully explored...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28125557/o-009-long-ncrna-landscape-in-the-ileum-of-treatment-na%C3%A3-ve-early-onset-crohn-disease
#6
Yael Haberman, Marina Ben-Shoshan, Ayelet Di-Segni, Phillip Dexheimer, Tzipi Klein, Batya Weiss, Thomas Walters, Robert Baldassano, Joshua Noe, James Markowitz, Mel Heyman, Joel Rosh, Anne Griffiths, Wallace Crandall, Bruce Aronow, Yair Anikster, Jeffrey Hyams, Subra Kugathasan, Lee Denson
BACKGROUND: Long non-coding RNAs (lncRNA) regulate gene transcription and diverse cellular functions. We have recently reported a core inflammatory and metabolic ileal gene signature in treatment naïve pediatric Crohn Disease (CD), but the potential role of lncRNA was not known. We hypothesized that differences in ileal lncRNA would be associated with differences in protein-coding gene expression, suggesting a role for lncRNA in regulating those gene signatures. METHODS: Poly-A selected RNA-seq and Ensembl annotation were used to define differentially expressed ileal genes with false discovery rate correction of 0...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28122089/anril-a-regulator-of-vegf-in-diabetic-retinopathy
#7
Anu Alice Thomas, Biao Feng, Subrata Chakrabarti
Purpose: Long noncoding RNAs (lncRNAs) previously thought to be "dark matter" of the genome, play key roles in various biological processes. The lncRNA ANRIL is located at a genetic susceptibility locus for coronary artery diseases and type 2 diabetes. We examined the role of ANRIL in diabetic retinopathy, through study of its regulation of VEGF both in vitro and in vivo. Methods: Human retinal endothelial cells (HRECs) were subjected to incubation in high glucose to mimic diabetes...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28117929/downregulation-of-lncrna-anril-represses-tumorigenicity-and-enhances-cisplatin-induced-cytotoxicity-via-regulating-microrna-let-7a-in-nasopharyngeal-carcinoma
#8
Yandan Wang, Nan Cheng, Junpeng Luo
Many studies have demonstrated that upregulation of long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) plays an oncogenic role in various tumors, including nasopharyngeal carcinoma (NPC). The aim of this study is to explore the effect of ANRIL in NPC progression and cisplatin (DDP)-induced cytotoxicity. The results showed that ANRIL was highly expressed and let-7a was downregulated in NPC tissues and cells. Luciferase assay revealed that ANRIL could negatively regulate miR-let-7a expression...
January 24, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28107200/variants-in-anril-gene-correlated-with-its-expression-contribute-to-myocardial-infarction-risk
#9
Jie Cheng, Meng-Yun Cai, Yu-Ning Chen, Zhi-Cheng Li, Sai-Sai Tang, Xi-Li Yang, Can Chen, Xinguang Liu, Xing-Dong Xiong
ANRIL (antisense non-coding RNA in the INK4 locus), located at the 9p21.3 locus, has been known to be closely associated with the risk of coronary artery disease (CAD). To date, studies of the 9p21.3 variants on CAD risk mainly focus on the non-coding region of ANRIL. However, the biological significance of the variants on ANRIL promoter and exons is still unknown. Here we investigate whether the variants on ANRIL promoter and exons have an effect on myocardial infarction (MI) risk, and further analyze the association of these variants with the expression of ANRIL transcript...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28060742/overexpression-of-lncrna-anril-up-regulates-vegf-expression-and-promotes-angiogenesis-of-diabetes-mellitus-combined-with-cerebral-infarction-by-activating-nf-%C3%AE%C2%BAb-signaling-pathway-in-a-rat-model
#10
Bo Zhang, Dan Wang, Tie-Feng Ji, Lei Shi, Jin-Lu Yu
OBJECTIVE: This study aimed to explore the effects of lncRNA ANRIL on vascular endothelial growth factor (VEGF) and angiogenesis in diabetes mellitus (DM) combined with cerebral infarction (CI) through NF-κB signaling pathway. METHODS: Adult male Wistar rats were randomly divided into control group and DM + CI group, and the DM + CI group were subdivided into Vector, shANRIL, PDTC, pcDNA-ANRIL, and pcDNA-ANRIL + PDTC groups. VEGF and FMS-like tyrosine kinase (FLT-1) expressions were measured by immunohistochemistry and endothelium dependent microvessel density (MVD) was detected by differentiation 31 (CD31) and para-amiuosalicylic acid (PAS) double staining...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28057453/association-of-anril-gene-polymorphisms-with-major-adverse-cardiovascular-events-in-hemodialysis-patients
#11
A Arbiol-Roca, A Padró-Miquel, M Hueso, E Navarro, P Alía-Ramos, M T González-Álvarez, I Rama, J Torras, J M Grinyó, J M Cruzado, N Lloberas
BACKGROUND: Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). Single nucleotide polymorphisms (SNPs) in ANRIL gene have been associated with higher cardiovascular morbidity and mortality in general population. The main objective was to ascertain whether ANRIL polymorphisms could identify risk of major adverse cardiovascular event (MACE) in patients starting on hemodialysis (HD). METHODS: This was a prospective observational cohort study...
March 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27919948/long-noncoding-rna-snar-regulates-proliferation-migration-and-invasion-of-triple-negative-breast-cancer-cells
#12
Jeeyeon Lee, Jin Hyang Jung, Yee Soo Chae, Ho Yong Park, Wan Wook Kim, Soo Jung Lee, Jae-Hwan Jeong, Seung Hee Kang
AIM: We evaluated the role of long noncoding ribonucleic acid (lncRNA) in breast cancer cell lines by quantitative reverse transcription-polymerase change reaction. MATERIALS AND METHODS: The effects of small NF90-associated RNA (snaR) with RNA interference on proliferation, migration and invasion of MDA-MB-231 cells were observed by 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, wound healing and transwell assay. RESULTS: Among 90 lncRNAs, E2F transcription factor 4, p107/p130-binding (E2F4) antisense, insulin-like growth factor 2 antisense (IGF2AS), snaR, and small nucleolar RNA host gene 5 (SNHG5) were up-regulated in MDA-MB-231 and 7SK, antisense noncoding RNA in the INK4 locus (ANRIL), IGF2AS, Nespas, p53 mRNA, and snaR were up-regulated in MCF-7 cells...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27899255/long-non-coding-rna-anril-indicates-a-poor-prognosis-of-cervical-cancer-and-promotes-carcinogenesis-via-pi3k-akt-pathways
#13
Dongli Zhang, Guixia Sun, Hongxia Zhang, Jun Tian, Yanyun Li
Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are playing critical roles in tumorgenesis. LncRNA ANRIL has been reported to promote tumor progression in types of cancers. However, the expression and function of ANRIL in cervical cancer are still largely unclear. We measured the expression of ANRIL in cervical cancer tissues and cell lines and analyzed its association with clinicopathological features and prognosis. Loss-of-function experiments were used to identify the biological function of ANRIL...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27894414/anril-rs2383207-polymorphism-and-coronary-artery-disease-cad-risk-a-meta-analysis-with-observational-studies
#14
P Wang, P Dong, X Yang
Some studies investigated the association of antisense non-coding RNA in the INK4 locus (ANRIL) rs2383207 polymorphism with coronary artery disease (CAD) risk. However, the result was still inconsistent. The aim of this study was to investigate whether there is an association between the ANRIL rs2383207 polymorphism and CAD risk. We carried out a PubMed (Medline), EMBASE database search covering all published articles. The strength of association between ANRIL rs2383207 polymorphism and CAD risk was assessed by calculating OR with 95% CI...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27833074/the-prognostic-value-of-long-non-coding-rnas-in-non-small-cell-lung-cancer-a-meta-analysis
#15
Manni Wang, Xuelei Ma, Chenjing Zhu, Linghong Guo, Qingfang Li, Ming Liu, Jing Zhang
BACKGROUND: Reports have demonstrated the prognostic function of long non-coding RNAS (lncRNAS) in patients with cancer. However, their prognostic functions in non small cell lung cancer (NSCLC) remain controversial. We therefore performed a meta-analysis on six lncRNAs (PVT1, AFAP1-AS1, LINC01133, ANRIL, MEG3 and UCA1) to clarify their prognostic roles in NSCLC. RESULTS: Thirty-six studies involving 6267 patients with NSCLC and 34 lncRNAs were included. Of the listed lncRNAs, 20 were shown to negatively affect patients' overall survival while the high expression of 13 lncRNAs indicated better survival outcomes...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27753829/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#16
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27688736/long-noncoding-rna-anril-is-activated-by-hypoxia-inducible-factor-1%C3%AE-and-promotes-osteosarcoma-cell-invasion-and-suppresses-cell-apoptosis-upon-hypoxia
#17
Xiaokang Wei, Chuanshun Wang, Chunhui Ma, Wei Sun, Haoqing Li, Zhendong Cai
BACKGROUND: Osteosarcoma is the most common malignancy of bone. Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of aggressive phenotype. ANRIL has been shown to be a long noncoding RNA that facilitates the progression of a number of malignancies. Yet, few studies have explored the expression pattern of ANRIL in osteosarcoma and the effect of hypoxia on ANRIL. METHODS: We evaluated the expression levels of ANRIL in osteosarcoma tissues, adjacent normal tissues and cells with quantitative real-time polymerase chain reaction...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27642882/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#18
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27594927/dna-methylation-at-birth-within-the-promoter-of-anril-predicts-markers-of-cardiovascular-risk-at-9%C3%A2-years
#19
Robert Murray, Jennifer Bryant, Phil Titcombe, Sheila J Barton, Hazel Inskip, Nicholas C Harvey, Cyrus Cooper, Karen Lillycrop, Mark Hanson, Keith M Godfrey
AIMS: Antisense non-coding RNA in the INK4 locus (ANRIL) fixed genetic variants have consistently been linked with coronary heart disease (CHD) risk. We investigated relationships between perinatal ANRIL promoter DNA methylation and CHD risk markers in children aged 9 years. Genetic variants in the non-coding RNA ANRIL identify it as an important CHD risk locus. Increasing evidence suggests that the early life environment may act through epigenetic processes to influence later CHD risk markers such as increased arterial pulse wave velocity (PWV, a measure of arterial stiffness) blood pressure or heart rate...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27557514/lncrna-anril-is-up-regulated-in-nasopharyngeal-carcinoma-and-promotes-the-cancer-progression-via-increasing-proliferation-reprograming-cell-glucose-metabolism-and-inducing-side-population-stem-like-cancer-cells
#20
Zhen Wei Zou, Charlie Ma, Lorraine Medoro, Lili Chen, Bin Wang, Roohi Gupta, Ting Liu, Xian Zi Yang, Tian Tian Chen, Ruo Zhen Wang, Wen Jie Zhang, Pin Dong Li
Long noncoding RNAs play a vital role in diverse biological processes such as embryonic development, cell growth, and tumorigenesis. In this study, we report that LncRNA ANRIL, which encodes a 3834-nt RNA that contains 19 exons at the antisense orientation of the INK4B-ARF-INK4A gene cluster, generally up-regulated in nasopharyngeal carcinoma [1]. In a cohort of 88 NPC patients, ANRIL was highly expressed in advanced-stage cancer. Multivariate analyses revealed that ANRIL expression could serve as an independent predictor of overall survival (P = 0...
September 20, 2016: Oncotarget
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