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https://www.readbyqxmd.com/read/27899255/long-non-coding-rna-anril-indicates-a-poor-prognosis-of-cervical-cancer-and-promotes-carcinogenesis-via-pi3k-akt-pathways
#1
Dongli Zhang, Guixia Sun, Hongxia Zhang, Jun Tian, Yanyun Li
Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are playing critical roles in tumorgenesis. LncRNA ANRIL has been reported to promote tumor progression in types of cancers. However, the expression and function of ANRIL in cervical cancer are still largely unclear. We measured the expression of ANRIL in cervical cancer tissues and cell lines and analyzed its association with clinicopathological features and prognosis. Loss-of-function experiments were used to identify the biological function of ANRIL...
November 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27894414/anril-rs2383207-polymorphism-and-coronary-artery-disease-cad-risk-a-meta-analysis-with-observational-studies
#2
P Wang, P Dong, X Yang
Some studies investigated the association of antisense non-coding RNA in the INK4 locus (ANRIL) rs2383207 polymorphism with coronary artery disease (CAD) risk. However, the result was still inconsistent. The aim of this study was to investigate whether there is an association between the ANRIL rs2383207 polymorphism and CAD risk. We carried out a PubMed (Medline), EMBASE database search covering all published articles. The strength of association between ANRIL rs2383207 polymorphism and CAD risk was assessed by calculating OR with 95% CI...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27833074/the-prognostic-value-of-long-non-coding-rnas-in-non-small-cell-lung-cancer-a-meta-analysis
#3
Manni Wang, Xuelei Ma, Chenjing Zhu, Linghong Guo, Qingfang Li, Ming Liu, Jing Zhang
BACKGROUND: Reports have demonstrated the prognostic function of long non-coding RNAS (lncRNAS) in patients with cancer. However, their prognostic functions in non small cell lung cancer (NSCLC) remain controversial. We therefore performed a meta-analysis on six lncRNAs (PVT1, AFAP1-AS1, LINC01133, ANRIL, MEG3 and UCA1) to clarify their prognostic roles in NSCLC. RESULTS: Thirty-six studies involving 6267 patients with NSCLC and 34 lncRNAs were included. Of the listed lncRNAs, 20 were shown to negatively affect patients' overall survival while the high expression of 13 lncRNAs indicated better survival outcomes...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27753829/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#4
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27688736/long-noncoding-rna-anril-is-activated-by-hypoxia-inducible-factor-1%C3%AE-and-promotes-osteosarcoma-cell-invasion-and-suppresses-cell-apoptosis-upon-hypoxia
#5
Xiaokang Wei, Chuanshun Wang, Chunhui Ma, Wei Sun, Haoqing Li, Zhendong Cai
BACKGROUND: Osteosarcoma is the most common malignancy of bone. Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of aggressive phenotype. ANRIL has been shown to be a long noncoding RNA that facilitates the progression of a number of malignancies. Yet, few studies have explored the expression pattern of ANRIL in osteosarcoma and the effect of hypoxia on ANRIL. METHODS: We evaluated the expression levels of ANRIL in osteosarcoma tissues, adjacent normal tissues and cells with quantitative real-time polymerase chain reaction...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27642882/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#6
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27594927/dna-methylation-at-birth-within-the-promoter-of-anril-predicts-markers-of-cardiovascular-risk-at-9%C3%A2-years
#7
Robert Murray, Jennifer Bryant, Phil Titcombe, Sheila J Barton, Hazel Inskip, Nicholas C Harvey, Cyrus Cooper, Karen Lillycrop, Mark Hanson, Keith M Godfrey
AIMS: Antisense non-coding RNA in the INK4 locus (ANRIL) fixed genetic variants have consistently been linked with coronary heart disease (CHD) risk. We investigated relationships between perinatal ANRIL promoter DNA methylation and CHD risk markers in children aged 9 years. Genetic variants in the non-coding RNA ANRIL identify it as an important CHD risk locus. Increasing evidence suggests that the early life environment may act through epigenetic processes to influence later CHD risk markers such as increased arterial pulse wave velocity (PWV, a measure of arterial stiffness) blood pressure or heart rate...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27557514/lncrna-anril-is-up-regulated-in-nasopharyngeal-carcinoma-and-promotes-the-cancer-progression-via-increasing-proliferation-reprograming-cell-glucose-metabolism-and-inducing-side-population-stem-like-cancer-cells
#8
Zhen Wei Zou, Charlie Ma, Lorraine Medoro, Lili Chen, Bin Wang, Roohi Gupta, Ting Liu, Xian Zi Yang, Tian Tian Chen, Ruo Zhen Wang, Wen Jie Zhang, Pin Dong Li
Long noncoding RNAs play a vital role in diverse biological processes such as embryonic development, cell growth, and tumorigenesis. In this study, we report that LncRNA ANRIL, which encodes a 3834-nt RNA that contains 19 exons at the antisense orientation of the INK4B-ARF-INK4A gene cluster, generally up-regulated in nasopharyngeal carcinoma [1]. In a cohort of 88 NPC patients, ANRIL was highly expressed in advanced-stage cancer. Multivariate analyses revealed that ANRIL expression could serve as an independent predictor of overall survival (P = 0...
August 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27539542/circular-non-coding-rna-anril-modulates-ribosomal-rna-maturation-and-atherosclerosis-in-humans
#9
Lesca M Holdt, Anika Stahringer, Kristina Sass, Garwin Pichler, Nils A Kulak, Wolfgang Wilfert, Alexander Kohlmaier, Andreas Herbst, Bernd H Northoff, Alexandros Nicolaou, Gabor Gäbel, Frank Beutner, Markus Scholz, Joachim Thiery, Kiran Musunuru, Knut Krohn, Matthias Mann, Daniel Teupser
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers atheroprotection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. CircANRIL binds to pescadillo homologue 1 (PES1), an essential 60S-preribosomal assembly factor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular smooth muscle cells and macrophages...
August 19, 2016: Nature Communications
https://www.readbyqxmd.com/read/27507052/long-non-coding-rna-anril-promotes-the-invasion-and-metastasis-of-thyroid-cancer-cells-through-tgf-%C3%AE-smad-signaling-pathway
#10
Jian-Jie Zhao, Shuai Hao, Ling-Li Wang, Chun-Yan Hu, Shu Zhang, Ling-Ji Guo, Gang Zhang, Bo Gao, Yan Jiang, Wu-Guo Tian, Dong-Lin Luo
OBJECTIVE: To investigate the effect of antisense non-coding RNA in the INK4 locus (ANRIL) on invasion and metastasis of thyroid cancer (TC). RESULTS: ANRIL expression was significantly up-regulated in TC tissues and cells (P < 0.001), and ANRIL expression was significantly different regarding histological grade and LNM (both P < 0.01). The siRNA-mediated ANRIL silencing inhibits proliferation, invasion, and metastasis of TPC-1 and SW579 cells, and lung metastasis, which can be reversed by TGF-β1 siRNA...
August 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27461581/anril-lncrna-triggers-efficient-therapeutic-efficacy-by-reprogramming-the-aberrant-ink4-hub-in-melanoma
#11
Shiqiong Xu, Huixue Wang, Hui Pan, Yingyun Shi, Tianyuan Li, Shengfang Ge, Renbing Jia, He Zhang, Xianqun Fan
Melanoma is an extremely aggressive disease with rapid progression, high metastatic potential and recurrence. Simultaneous correction of multiple tumor-specific gene abnormalities has become an attractive approach for developing therapeutics to treat melanoma. To potentiate anti-melanoma activity, we tested a "domino effect-like" therapeutic approach by uniquely targeting one defect and automatically triggering the endogenous corrections of other defects. Using this strategy, in a suspicious INK4b-ARF-INK4a gene cluster at chromosome 9p21, aberrant INK4a and INK4b defects were simultaneously endogenously auto-corrected after targeting the suppression of abnormal ANRIL lncRNA...
October 10, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27356775/the-9p21-locus-and-its-potential-role-in-atherosclerosis-susceptibility-molecular-mechanisms-and-clinical-implications
#12
Amir Tajbakhsh, Seyed Mahdi Hassanian, Mohammad Sadegh Khorrami, Alireza Pasdar, Ehsan Tabatabai, Seyed Mohammad Reza Parizadeh, Mostafa Fazeli, Sharareh Gholamin, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan
Cardiovascular disease (CVD) is the leading cause of global mortality. Although extensive efforts have been made to identify valid biomarkers for CVD risk, relatively ¬¬¬few are of proven clinical utility. It is recognized that genetic factors play a major role in determining the susceptibility to CVD. Recent genome-wide-association-studies have demonstrated common genetic variants in a region on chromosome 9p21 associated with an increased risk of CVD. Several genetic-polymorphisms have been identified in this region that are highly associated with CVD, and these are clustered around the gene loci for CDKN2B (coding for p15ink4b), CDKN2A (coding for p16ink4a and p14ARF) and the 3' end of CDKN2BAS, which has been termed antisense noncoding RNA in the INK4 locus (ANRIL)...
June 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27326334/structure-guided-discovery-of-selective-antagonists-for-the-chromodomain-of-polycomb-repressive-protein-cbx7
#13
Chunyan Ren, Steven G Smith, Kyoko Yap, SiDe Li, Jiaojie Li, Mihaly Mezei, Yoel Rodriguez, Adam Vincek, Francesca Aguilo, Martin J Walsh, Ming-Ming Zhou
The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus. In this study, we report structure-guided discovery of two distinct classes of small-molecule antagonists for the CBX7ChD. Our Class A compounds, a series including analogues of the previously reported MS452, inhibit CBX7ChD/methyl-lysine binding by occupying the H3K27me3 peptide binding site, whereas our Class B compound, the newly discovered MS351, appears to inhibit H3K27me3 binding when CBX7ChD is bound to RNA...
June 9, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27317124/long-noncoding-rna-dysregulation-in-ischemic-heart-failure
#14
Simona Greco, Germana Zaccagnini, Alessandra Perfetti, Paola Fuschi, Rea Valaperta, Christine Voellenkle, Serenella Castelvecchio, Carlo Gaetano, Nicoletta Finato, Antonio Paolo Beltrami, Lorenzo Menicanti, Fabio Martelli
BACKGROUND: Long noncoding RNAs (lncRNAs) are non-protein coding transcripts regulating a variety of physiological and pathological functions. However, their implication in heart failure is still largely unknown. The aim of this study is to identify and characterize lncRNAs deregulated in patients affected by ischemic heart failure. METHODS: LncRNAs were profiled and validated in left ventricle biopsies of 18 patients affected by non end-stage dilated ischemic cardiomyopathy and 17 matched controls...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27314206/anril-is-associated-with-the-survival-rate-of-patients-with-colorectal-cancer-and-affects-cell-migration-and-invasion-in%C3%A2-vitro
#15
Yi Sun, Zhao-Peng Zheng, Hang Li, Han-Qun Zhang, Fa-Qiang Ma
Antisense noncoding RNA in the INK4 locus (ANRIL) has been reported to be upregulated in various types of human cancer, and is also highly expressed in normal human tissue. The aim of the present study was to identify whether ANRIL may be a possible target for colorectal cancer (CRC) therapy. Reverse transcription‑quantitative polymerase chain reaction was used to quantify the expression levels of the long noncoding RNA (lncRNA) ANRIL in 97 paired CRC and adjacent non‑neoplastic tissue samples. In addition, the HT29 and RKO human CRC cell lines underwent ANRIL RNA interference, and knockdown efficiency was evaluated by western blotting...
August 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27307748/long-noncoding-rna-anril-could-be-transactivated-by-c-myc-and-promote-tumor-progression-of-non-small-cell-lung-cancer
#16
Yi Lu, Xiaohui Zhou, Ling Xu, Chaohui Rong, Ce Shen, Wei Bian
In recent years, long noncoding RNAs (lncRNAs) have been demonstrated to play important roles in the development of human cancer. We assessed the role of lncRNA ANRIL in non-small-cell lung cancer (NSCLC). Quantitative real-time polymerase chain reaction was employed to detect the expression of ANRIL in NSCLC tissues and paired nontumor tissues. The high expression level of ANRIL was positively correlated with advanced tumor-node-metastasis stage and greater tumor diameter. Furthermore, chromatin immunoprecipitation assays confirmed the physical interaction between c-Myc and ANRIL...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27286457/downregulation-of-long-non-coding-rna-anril-suppresses-lymphangiogenesis-and-lymphatic-metastasis-in-colorectal-cancer
#17
Zhenqiang Sun, Chunlin Ou, Weiguo Ren, Xiang Xie, Xiayu Li, Guiyuan Li
This study aimed to investigate the effect of ANRIL on the lymphangiogenesis and lymphatic metastasis in colorectal cancer. Using RT-PCT and Northern blot, we detected ANRIL expression in tissues (cancer vs. normal) and cell lines (HCoEpic, SW480, HT29, LoVo and HCT116), finding that ANRIL was overexpressed in colorectal cancer. By statistical analysis, increased ANRIL was found to be in close association with TNM staging, Duke staging and lymphatic metastasis and poor prognosis. We down-regulated the high ANRIL expression in LoVo and HCT116 with lentivirus transfection, and found that the activity of cell mobility and invasion was remarkably reduced...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27176569/long-noncoding-rna-anril-a-potential-novel-prognostic-marker-in-cancer-a-meta-analysis
#18
REVIEW
Fang-Teng Liu, Pei-Qian Zhu, Hong-Liang Luo, Yi Zhang, Teng-Fei Hao, Guang-Fei Xia, Zheng-Ming Zhu, Cheng Qiu
INTRODUCTION: Numerous researches have showed that the dysregulation of lncRNA ANRIL play a significant role in cancer progression, and high expression of ANRIL may have important clinical value. This meta-analysis aims to investigate potential clinical application role of ANRIL as a biomarker for cancer prognosis. EVIDENCE ACQUISTION: The electronic search was conducted in Pubmed, EMBASE, Web of Science, CNKI and Wanfang database (up to January 27, 2016). We collected relevant articles to explore the association between the expression levels of ANRIL and overall survival (OS)...
April 2016: Minerva Medica
https://www.readbyqxmd.com/read/27155872/islet-biology-the-cdkn2a-b-locus-and-type-2-diabetes-risk
#19
REVIEW
Yahui Kong, Rohit B Sharma, Benjamin U Nwosu, Laura C Alonso
Type 2 diabetes, fuelled by the obesity epidemic, is an escalating worldwide cause of personal hardship and public cost. Diabetes incidence increases with age, and many studies link the classic senescence and ageing protein p16(INK4A) to diabetes pathophysiology via pancreatic islet biology. Genome-wide association studies (GWASs) have unequivocally linked the CDKN2A/B locus, which encodes p16 inhibitor of cyclin-dependent kinase (p16(INK4A)) and three other gene products, p14 alternate reading frame (p14(ARF)), p15(INK4B) and antisense non-coding RNA in the INK4 locus (ANRIL), with human diabetes risk...
August 2016: Diabetologia
https://www.readbyqxmd.com/read/27121324/silencing-of-long-non-coding-rna-anril-inhibits-the-development-of-multidrug-resistance-in-gastric-cancer-cells
#20
Wei-Guang Lan, Dian-Hong Xu, Chen Xu, Chang-Ling Ding, Fang-Ling Ning, Yan-Li Zhou, Long-Bo Ma, Chang-Min Liu, Xia Han
The development of multidrug resistance (MDR) is a crucial cause of therapy failure in gastric cancer, which results in disease recurrence and metastasis. Long non-coding RNAs (lncRNAs) have been proven to be critical in carcinogenesis and metastasis of gastric cancer. However, little is known about the roles of ANRIL (antisense non-coding RNA in the INK4 locus) in gastric cancer MDR. The aim of our study is to identify the biological function of ANRIL in gastric cancer MDR. In our results, ANRIL was highly expressed in gastric cancer tissues of cisplatin-resistant and 5-fluorouracil (5-FU)-resistant patients, and the same upregulation trends were observed in cisplatin-resistant cells (BGC823/DDP) and 5-FU-resistant cells (BGC823/5-FU)...
July 2016: Oncology Reports
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