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https://www.readbyqxmd.com/read/29449542/long-non-coding-rnas-in-ischemic-stroke
#1
REVIEW
Mei-Hua Bao, Vivian Szeto, Burton B Yang, Shu-Zhen Zhu, Hong-Shuo Sun, Zhong-Ping Feng
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29432124/cdkn2a-b-t2d-gwas-risk-snps-impact-locus-gene-expression-and-proliferation-in-human-islets
#2
Yahui Kong, Rohit B Sharma, Socheata Ly, Rachel E Stamateris, William M Jesdale, Laura C Alonso
Genome-wide association studies link the CDKN2A/B locus with T2D risk, but mechanisms increasing risk remain unknown. The CDKN2A/B locus encodes cell cycle inhibitors p14, p15, and p16, MTAP, and ANRIL, a lncRNA. The goal of this study was to determine whether CDKN2A/B T2D risk-SNPs impact locus gene expression, insulin secretion, or beta cell proliferation, in human islets. Islets from non-diabetic donors (n=95) were tested for SNP genotype (rs10811661, rs2383208, rs564398, rs10757283), gene expression (p14, p15, p16, MTAP, ANRIL, PCNA, KI67, CCND2), insulin secretion (n=61) and beta cell proliferation (n=47)...
February 6, 2018: Diabetes
https://www.readbyqxmd.com/read/29425892/lncrnas-in-vascular-biology-and-disease
#3
REVIEW
Viorel Simion, Stefan Haemmig, Mark W Feinberg
Accumulating studies indicate that long non-coding RNAs (lncRNAs) play important roles in the regulation of diverse biological processes involved in homeostatic control of the vessel wall in health and disease. However, our knowledge of the mechanisms by which lncRNAs control gene expression and cell signaling pathways is still nascent. Furthermore, only a handful of lncRNAs has been functionally evaluated in response to pathophysiological stimuli or in vascular disease states. For example, lncRNAs may regulate endothelial dysfunction by modulating endothelial cell proliferation (e...
February 6, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29278879/overexpression-of-lncrna-anril-promoted-the-proliferation-and-migration-of-prostate-cancer-cells-via-regulating-let-7a-tgf-%C3%AE-1-smad-signaling-pathway
#4
Bin Zhao, Yong Yang, Li-Bing Hu, Yu Bai, Rui-Qian Li, Guo-Yin Zhang, Jun Li, Cheng-Wei Bi, Li-Bo Yang, Chen Hu, Yong-Hong Lei, Qi-Lin Wang, Zhi-Min Liu, Yu-Lin Lu
Long non-coding RNAs (lncRNAs) were playing critical roles in tumorigenesis. However, in prostate cancer, the roles and mechanisms of lncRNAs especially ANRIL were largely unknown. We investigated the effects of ANRIL on the proliferation and migration of prostate cancer cells using CCK-8 assay and Transwell migration assay. Real-time PCR and western blotting assays were used to analyze the levels of ANRIL, let-7a, TGF-β1, p-Smad2 and p-Smad7. Our results showed that ANRIL was significantly overexpressed in prostate cancer tissues compared with corresponding normal tissues...
December 15, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29240242/the-9p21-locus-a-potential-therapeutic-target-and-prognostic-marker-in-breast-cancer
#5
REVIEW
Mahdi Rivand, Mohammad-Sadegh Khorrami, Hamid Fiuji, Soodabeh Shahidsales, Malihe Hasanzadeh, Mir Hadi Jazayeri, Seyed Mahdi Hassanian, Gordon A Ferns, Nafiseh Saghafi, Amir Avan
Breast cancer is an important cause of cancer related mortality in women. Despite extensive efforts to identify valid biomarkers for risk stratification, there are relatively few with proven clinical utility. It is recognized that genetic factors play a major role in determining susceptibility to breast cancer. Recent genome-wide-association-studies and gene expression analysis have demonstrated that a locus on chromosome 9p21, which contains three genes; CDKN2B (encoding p15ink4b), CDKN2A (encoding p16ink4a and p14ARF) and the 3' end of CDKN2BAS [an antisense noncoding RNA in the INK4 locus (ANRIL)] are associated with an increased risk of this malignancy...
December 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29201225/long-non-coding-rna-anril-promotes-the-proliferation-migration-and-invasion-of-human-osteosarcoma-cells
#6
Shuo Cheng, Tao Huang, Pengcheng Li, Wei Zhang, Zhihang Wang, Yao Chen
The long antisense non-coding RNA ANRIL is 3.8 kb in length and serves an important role in the tumorigenesis and progression of a number of malignancies. However, its function in human osteosarcoma remains unknown. The present study investigated the role of ANRIL in human osteosarcoma cell lines and clinical tumor samples. The expression of ANRIL was analyzed in 19 osteosarcoma and paired adjacent non-cancerous tissues using reverse transcription-quantitative polymerase chain reaction. Knockdown of ANRIL expression using lentivirus-mediated small interfering RNA was performed to investigate the role of ANRIL in tumor proliferation and metastasis using MTT, colony formation and transwell assays...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29176691/midkine-derived-from-cancer-associated-fibroblasts-promotes-cisplatin-resistance-via-up-regulation-of-the-expression-of-lncrna-anril-in-tumour-cells
#7
Dongya Zhang, Liang Ding, Yi Li, Jing Ren, Guoping Shi, Yong Wang, Shuli Zhao, Yanhong Ni, Yayi Hou
Midkine (MK) is a heparin-binding growth factor that promotes carcinogenesis and chemoresistance. The tumour microenvironment (TME) can affect chemotherapy sensitivity. However, the role of stromal-derived MK, especially in cancer-associated fibroblasts (CAFs), is unclear. Here, we confirmed that MK decreased cisplatin-induced cell death in oral squamous cell carcinoma (OSCC) cells, ovarian cancer cells and lung cancer cells. We also isolated primary CAFs (n = 3) from OSCC patients and found that CAFs secreted increased levels of MK, which abrogated cisplatin-induced cell death...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146581/long-noncoding-rnas-emerging-players-in-thyroid-cancer-pathogenesis
#8
Avaniyapuram Kannan Murugan, Munirajan Arasambattu Kannan, Ali S Alzahrani
Thyroid cancer continues to be the most common malignancy of endocrine glands. The incidence of thyroid cancer rises significantly over the past 4 decades and emerges as a major health issue. In recent years, a significant progress has been achieved in our understanding of molecular mechanisms of thyroid carcinogenesis, resulting in significant diagnostic, prognostic and therapeutic implications; yet, it has not reached a satisfactory level. Identifying novel molecular therapeutic targets and molecules for diagnosis and prognosis are expected to advance the overall management of this common malignancy...
November 16, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29127494/knockdown-of-lncrna-anril-suppresses-cell-proliferation-metastasis-and-invasion-via-regulating-mir-122-5p-expression-in-hepatocellular-carcinoma
#9
Ji Ma, Tengfei Li, Xinwei Han, Huifeng Yuan
OBJECTIVE: Previous studies reported that lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) was upregulated in hepatocellular carcinoma (HCC) tissues and decreased expression of ANRIL could suppress cell proliferation, metastasis, and invasion and induce apoptosis of HCC cells. However, the molecular mechanism of ANRIL involved in HCC tumorigenesis is still unknown. METHODS: The expressions of ANRIL and miR-122-5p in HCC tissues and cells were quantified by qRT-PCR...
November 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29118015/anril-regulates-production-of-extracellular-matrix-proteins-and-vasoactive-factors-in-diabetic-complications
#10
Anu Alice Thomas, Biao Feng, Subrata Chakrabarti
Long non-coding RNAs (lncRNAs) have gained widespread interest due to their prevailing presence in various diseases. lncRNA ANRIL (a.k.a CDKN2B-AS1) is located on human chromosome 9 (p21.3) and transcribed in opposite direction to INK4b-ARF-INK4a gene cluster. It has been identified as highly susceptible region for diseases such as coronary artery diseases and Type 2 Diabetes. Here we explored its regulatory role in diabetic nephropathy (DN) and diabetic cardiomyopathy (DCM) in association with epigenetic modifiers p300 and polycomb repressive complex 2 (PRC2) complex...
November 7, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29057547/knockdown-of-long-non-coding-rna-anril-inhibits-proliferation-migration-and-invasion-but-promotes-apoptosis-of-human-glioma-cells-by-upregulation-of-mir-34a
#11
Xuechao Dong, Zheng Jin, Yong Chen, Haiyang Xu, Chengyuan Ma, Xinyu Hong, Yunqian Li, Gang Zhao
Gliomas are the most common types of primary central nervous system malignancy found in adults. Long non-coding RNA antisense non-coding RNA in the INK4 locus (ANRIL) variants are associated with glioma and miR-34a is markedly downregulated in U251 glioma cells. The 3'-untranslated region (3'UTR) of silent information regulator 1 (Sirt1) contains a conserved site that is targeted directly by miR-34a. Therefore, in this study, we investigated the roles of ANRIL, miR-34a and Sirt1 in glioma and their potential interactions...
October 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29035780/long-non-coding-rnas-in-the-atherosclerotic-plaque
#12
Serdal Arslan, Öcal Berkan, Torkia Lalem, Nil Özbilüm, Sabahattin Göksel, Özge Korkmaz, Nilgün Çetin, Yvan Devaux
BACKGROUND AND AIMS: Genetic and environmental factors are important components of the development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as regulators of multiple pathophysiological pathways in the cardiovascular system. Here, we investigated potential associations between lncRNAs and atherosclerosis. METHODS: Tissue samples from atherosclerotic coronary artery plaques and non-atherosclerotic internal mammary artery were obtained from 20 patients during coronary artery bypass surgery...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29030863/hotair-but-not-anril-long-non-coding-rna-contributes-to-the-pathogenesis-of-multiple-sclerosis
#13
Majid Pahlevan Kakhki, Abbas Nikravesh, Zeinab Shirvani Farsani, Mohammad Ali Sahraian, Mehrdad Behmanesh
Different studies have revealed that dysregulation in gene expression is one of the main aspects of multiple sclerosis (MS) pathogenesis. Although the molecular pathways underlying the immunomodulatory role of vitamin D (VD) in MS is not completely elucidated, VD has more recently become a topic of interest in immune regulation and is widely administrated to MS patients as an immunomodulatory supplement. Long non-coding RNAs (lncRNAs) are known to play important roles in regulation of gene expression via different mechanisms...
October 14, 2017: Immunology
https://www.readbyqxmd.com/read/29025584/regulatory-mechanisms-of-long-noncoding-rnas-on-gene-expression-in-cancers
#14
REVIEW
Weiliang Sun, Yunben Yang, Chunjing Xu, Junming Guo
Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are non-protein coding transcripts longer than 200 nucleotides. In this review, we introduce the mechanisms by which lncRNAs regulate gene expression in four parts, epigenetic regulation (genetic imprinting and chromatin remodeling), transcriptional regulation (molecular decoy), post-transcriptional regulation (splicing and mRNA decay), and translational regulation. H19, Xist, and others are involved in genomic imprinting. HOTAIR and ANRIL function in chromatin remodeling...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28970468/prognostic-value-of-plasma-long-noncoding-rna-anril-for-in-stent-restenosis
#15
Fang Wang, Xi Su, Chengwei Liu, Mingxiang Wu, Bei Li
BACKGROUND In-stent restenosis (ISR) remains a major cause of failure of contemporary percutaneous revascularization therapies. Invasive biomarkers to improve the prognosis of ISR should be considered. This study aimed to investigate the association between plasma ANRIL expression and ISR. MATERIAL AND METHODS A total of 444 patients were included in this research. Serial coronary angiography was performed at baseline (before and after intervention) and within 36 months' follow-up. ISR was defined as >50% diameter stenosis at follow-up...
October 3, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28961506/long-non-coding-rna-anril-promotes-carcinogenesis-via-sponging-mir-199a-in-triple-negative-breast-cancer
#16
Shuang-Ta Xu, Jian-Hua Xu, Zheng-Rong Zheng, Qing-Quan Zhao, Xiao-Shan Zeng, Si-Xian Cheng, Ying-Hui Liang, Qing-Fu Hu
Triple-negative breast cancer (TNBC) is a complex breast cancer subtype characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2). Long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) has been verified as oncogenic molecular in series of tumors, however, the role of ANRIL in TNBC carcinogenesis is still unclear. The purpose of present study is to investigate the expression and in-depth regulation of ANRIL on TNBC tumorigenesis...
September 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28950881/erratum-to-long-non-coding-rna-anril-is-upregulated-in-hepatocellular-carcinoma-and-regulates-cell-proliferation-by-epigenetic-silencing-of-klf2
#17
Ming-de Huang, Wen-Ming Chen, Fu-Zhen Qi, Rui Xia, Ming Sun, Tong-Peng Xu, Li Yin, Er-Bao Zhang, Wei De, Yong-Qian Shu
No abstract text is available yet for this article.
July 27, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28879612/how-long-noncoding-rnas-enforce-their-will-on-mitochondrial-activity-regulation-of-mitochondrial-respiration-reactive-oxygen-species-production-apoptosis-and-metabolic-reprogramming-in-cancer
#18
REVIEW
Boel De Paepe, Steve Lefever, Pieter Mestdagh
The cellular transcriptome contains a wide diversity of untranslated RNAs, of which the class of regulatory long noncoding RNAs (lncRNAs) has only recently been recognized. Evidence swiftly accumulates of lncRNAs influencing mitochondrial activities of eukaryotic cells, and perturbed expression is conspicuously associated with human diseases. In this review, we describe the multifaceted effects of lncRNAs on mitochondrial function, more particularly on the balance between oxidative phosphorylation and glycolysis, on the production of reactive oxygen species, and on apoptosis in human cells...
September 6, 2017: Current Genetics
https://www.readbyqxmd.com/read/28874676/linc-ing-circulating-long-non-coding-rnas-to-the-diagnosis-and-malignant-prediction-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#19
Jennifer B Permuth, Dung-Tsa Chen, Sean J Yoder, Jiannong Li, Andrew T Smith, Jung W Choi, Jongphil Kim, Yoganand Balagurunathan, Kun Jiang, Domenico Coppola, Barbara A Centeno, Jason Klapman, Pam Hodul, Florian A Karreth, Jose G Trevino, Nipun Merchant, Anthony Magliocco, Mokenge P Malafa, Robert Gillies
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic markers of incidentally-detected cystic PDAC precursors known as intraductal papillary mucinous neoplasms (IPMNs) and predictors of their pathology/histological classification. Using NanoString nCounter® technology, we measured the abundance of 28 candidate lncRNAs in pre-operative plasma from a cohort of pathologically-confirmed IPMN cases of various grades of severity and non-diseased controls...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869157/the-contribution-of-long-non-coding-rnas-in-inflammatory-bowel-diseases
#20
REVIEW
Eirini Zacharopoulou, Maria Gazouli, Maria Tzouvala, Antonios Vezakis, George Karamanolis
Inflammatory bowel diseases (IBDs) are multifactorial autoimmune diseases with growing prevalence but the interaction between genetic, environmental and immunologic factors in their development is complex and remains obscure. There is great need to understand their pathogenetic mechanisms and evolve diagnostic and therapeutic tools. Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that are known to interfere in gene regulation but their roles and functions have not yet been fully understood...
August 9, 2017: Digestive and Liver Disease
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