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Bronchitis antibiotics

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https://www.readbyqxmd.com/read/27922232/changing-epidemiology-of-non-cystic-fibrosis-bronchiectasis
#1
Semiha Bahçeci, Sait Karaman, Hikmet Tekin Nacaroğlu, Selçuk Yazıcı, Saniye Girit, Şule Ünsal-Karkıner, Demet Can
Non-cystic fibrosis bronchiectasis again becomes a major health problem due to inappropriate antibiotic use and increasing frequency of protracted bacterial bronchitis. The aim was to determine the changes in etiology of bronchiectasis. Patients who admitted to Behçet Uz Children Hospital between 2005 and 2015 (n=110) were retrospectively examined. The etiology of bronchiectasis was detected as; primary ciliary dyskinesia 26.4%, protracted bacterial bronchitis 22.8%, primary immune deficiency 11.8%, bronchiolitis obliterans 8...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27920515/effect-of-elom-080-on-exacerbations-and-symptoms-in-copd-patients-with-a-chronic-bronchitis-phenotype-a-post-hoc-analysis-of-a-randomized-double-blind-placebo-controlled-clinical-trial
#2
Kai-Michael Beeh, Jutta Beier, Henning Candler, Thomas Wittig
BACKGROUND: Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more tailored treatment approach has been proposed, in particular for two well-established clinical phenotypes, frequent exacerbators and chronic bronchitis-dominant COPD. ELOM-080 has demonstrated clinical efficacy in treating symptoms and preventing exacerbations in subjects with chronic bronchitis. However, little is known about the potential effects of ELOM-080 in COPD patients...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27911082/necrotizing-and-haemorrhagic-hepatitis-and-enteritis-in-commercial-layer-pullets
#3
Yuko Sato, William L Wigle, Tsang Long Lin, Eric Gingerich, Patricia S Wakenell
This case report describes an episode of recurring severe necrotizing and haemorrhagic hepatitis and enteritis experienced in a flock of commercial layer pullets at 12 weeks of age and again at 18 weeks of age in Indiana. Pullets had been vaccinated at 10 weeks old using a trivalent Salmonella Enteritidis (SE)/Newcastle disease/infectious bronchitis oil-emulsion-inactivated vaccine. The pullets were found dead at 12 weeks with firm but friable, enlarged, haemorrhagic livers, enlarged spleens, and necrohaemorrhagic intestines...
December 2, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27887585/reduction-in-antibiotic-prescribing-for-respiratory-tract-infections-in-swedish-primary-care-a-retrospective-study-of-electronic-patient-records
#4
Mia Tyrstrup, Anders Beckman, Sigvard Mölstad, Sven Engström, Christina Lannering, Eva Melander, Katarina Hedin
BACKGROUND: Swedish studies on antibiotic use in primary care have been based on one-week registrations of infections. In order to study adherence to guidelines, analyses based on large databases that provide information on diagnosis linked prescriptions, are needed. This study describes trends in management of infections in Swedish primary care particularly with regards to antibiotic prescribing and adherence to national guidelines. METHODS: A descriptive study of Sweden's largest database regarding diagnosis linked antibiotic prescription data, the Primary care Record of Infections in Sweden (PRIS), for the years 2008, 2010 and 2013...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27883116/zabofloxacin-for-chronic-bronchitis
#5
B Kocsis, D Szabo
Treatment of lower respiratory tract infection poses as an ongoing challenge among respiratory tract diseases. Bacterial infections are causes of acute exacerbations in chronic bronchitis and indications for antibacterial therapy. Several antibiotics were applied to treat bacterial infections in chronic bronchitis, among them fluoroquinolones are considered potent, broad-spectrum agents with excellent tissue penetration. This monograph focuses on zabofloxacin, a novel fluoroquinolone agent recently approved and launched in South Korea, and summarizes the drug's antibacterial efficacy, pharmacokinetic properties and toxicity...
September 2016: Drugs of Today
https://www.readbyqxmd.com/read/27812804/paediatric-antibiotic-prescriptions-in-primary-care-in-the-alpes-maritimes-area-of-southeastern-france-between-2008-and-2013
#6
P Touboul-Lundgren, P Bruno, L Bailly, B Dunais, C Pradier
France has remained among the top five European countries for ambulatory antibiotic consumption since such monitoring began in 1998. Young children are major antibiotic consumers, in spite of the viral origin of most infections in this population. Recommendations were updated in 2011 to limit prescriptions. In order to assess their impact, diagnoses and prescriptions were compared in a population of children attending daycare centres in southeastern France in 2008 and 2012. Trends in the reimbursement of paediatric antibiotic prescriptions by the national health insurance (NHI) for the whole area were also studied...
November 3, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27792075/reducing-inappropriate-antibiotic-prescribing-for-adults-with-acute-bronchitis-in-an-urgent-care-setting-a-quality-improvement-initiative
#7
Tamara L Link, Mary L Townsend, Eugene Leung, Sekhar Kommu, Rhonda Y Vega, Cristina C Hendrix
Acute bronchitis is a predominantly viral illness and, according to clinical practice guidelines, should not be treated with antibiotics. Despite clear guidelines, acute bronchitis continues to be the most common acute respiratory illness for which antibiotics are incorrectly prescribed. Although the national benchmark for antibiotic prescribing for adults with acute bronchitis is 0%, a preliminary record review before implementing the intervention at the project setting showed that 96% (N = 30) of adults with acute bronchitis in this setting were prescribed an antibiotic...
October 2016: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/27788254/microorganisms-causing-community-acquired-acute-bronchitis-the-role-of-bacterial-infection
#8
Ji Young Park, Sunghoon Park, Sun Hwa Lee, Myung Goo Lee, Yong Bum Park, Kil Chan Oh, Jae-Myung Lee, Do Il Kim, Ki-Hyun Seo, Kyeong-Cheol Shin, Kwang Ha Yoo, Yongchun Ko, Seung Hun Jang, Ki-Suck Jung, Yong Il Hwang
BACKGROUND: Although acute bronchitis is quite common, there is relatively limited information regarding the microorganisms that are involved in this illness. METHODS: We performed a prospective study of acute bronchitis at 31 hospitals and clinics in Korea from July 2011 to June 2012. Sputum specimens were collected for polymerase chain reaction (PCR) and culture of microorganisms. RESULTS: Of the 811 enrolled patients, 291 had acceptable sputum specimens that were included for analysis of the etiologic distribution...
2016: PloS One
https://www.readbyqxmd.com/read/27747036/extensive-plastic-bronchitis-etiology-of-a-rare-condition
#9
Norbert Garcia-Henriquez, Eric M Toloza, Farah Khalil, Maria F Echavarria, Joseph R Garrett, Carla C Moodie, Frank J Kaszuba, Jacques P Fontaine
We present the case of a 55-year-old man who developed extensive occlusive bronchial casts after trachea-esophageal (TE) fistula repair. The bronchial casts were treated by bronchoscopic extraction, high dose steroids, antibiotics, and antifungals. Despite this multi-modality treatment, the rapid formation of these occlusive bronchial casts was very aggressive and could not be controlled even with a series of five rigid bronchoscopic extractions within a 48-hour period. The patient quickly deteriorated and succumbed to the inflammatory state...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27734780/-is-procalcitonin-measurement-useful-in-managing-respiratory-tract-infections
#10
J M Prins, T van der Poll
Better use of current antibiotics is warranted to curb increasing antimicrobial resistance rates. Procalcitonin guidance can safely reduce antibiotic usage when used to initiate or discontinue antibiotics in adult patients with a respiratory tract infection. However, the claimed reductions in antibiotic usage are mainly achieved in patients with acute bronchitis and exacerbations of COPD, conditions for which guidelines already discourage antibiotic treatment. Sequential procalcitonin measurements can also reduce the treatment duration of community-acquired pneumonia from 10-12 to 5-7 days, which is, however, already the recommended treatment duration for in- and outpatients under the current Dutch guidelines...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27708777/cough-impact-beliefs-and-expectations-from-a-national-survey
#11
Roberto W Dal Negro, Massimiliano Mazzolini, Paola Turco, Alessandro Zanasi
BACKGROUND: Cough is one of the most common discomforts affecting general population, which can disrupt subjects' quality of life due to its physical, social, and psychological effects. Aim of the study was to investigate the impact of cough and related beliefs of general population. METHODS: A cross-sectional telephone survey was carried out by means of a specific, validated questionnaire on a representative sample of Italian general population. All the interviews were carried out according to the Computer Assisted Telephone Interview (CATI) methodology by expert, professional interviewers...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/27624570/antibiotic-prescriptions-for-suspected-respiratory-tract-infection-in-primary-care-in-south-america
#12
Gloria Cordoba, Lidia Caballero, Håkon Sandholdt, Fátima Arteaga, Monica Olinisky, Luis Fabián Ruschel, Marjukka Makela, Lars Bjerrum
OBJECTIVES: To describe and compare antibiotic prescribing patterns for primary care patients with respiratory tract infections (RTIs) in four South American countries. METHODS: This was a prospective observational study. General practitioners (GPs) from Argentina, Bolivia, Paraguay and Uruguay registered data about all consultations of patients with suspected RTIs in the winter of 2014 (June-August). Variation in antibiotic prescriptions was assessed using a two-level hierarchical logistic model...
September 13, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27613392/pharmacological-strategies-to-reduce-exacerbation-risk-in-copd-a-narrative-review
#13
REVIEW
Marc Miravitlles, Anthony D'Urzo, Dave Singh, Vladimir Koblizek
Identifying patients at risk of exacerbations and managing them appropriately to reduce this risk represents an important clinical challenge. Numerous treatments have been assessed for the prevention of exacerbations and their efficacy may differ by patient phenotype. Given their centrality in the treatment of COPD, there is strong rationale for maximizing bronchodilation as an initial strategy to reduce exacerbation risk irrespective of patient phenotype. Therefore, in patients assessed as frequent exacerbators (>1 exacerbation/year) we propose initial bronchodilator treatment with a long-acting muscarinic antagonist (LAMA)/ long-acting β2-agonist (LABA)...
September 10, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27574416/effects-of-roflumilast-in-copd-patients-receiving-inhaled-corticosteroid-long-acting-%C3%AE-2-agonist-fixed-dose-combination-re-2-spond-rationale-and-study-design
#14
Stephen I Rennard, Fernando J Martinez, Klaus F Rabe, Sanjay Sethi, Emilio Pizzichini, Andrew McIvor, Shahid Siddiqui, Antonio Anzueto, Haiyuan Zhu
BACKGROUND: Roflumilast, a once-daily, selective phosphodiesterase-4 inhibitor, reduces the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. The RE(2)SPOND study is examining whether roflumilast, when added to an inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) fixed-dose combination (FDC), further reduces exacerbations. The methodology is described herein. METHODS: In this Phase IV, multicenter, double-blind, placebo-controlled, parallel-group trial, participants were randomized 1:1 (stratified by long-acting muscarinic antagonist use) to receive roflumilast or placebo, plus ICS/LABA FDC, for 52 weeks...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27564413/age-and-small-airway-imaging-abnormalities-in-subjects-with-and-without-airflow-obstruction-in-spiromics
#15
Carlos H Martinez, Alejandro A Diaz, Catherine Meldrum, Jeffrey L Curtis, Christopher B Cooper, Cheryl Pirozzi, Richard E Kanner, Robert Paine Iii, Prescott G Woodruff, Eugene R Bleecker, Nadia N Hansel, R Graham Barr, Nathaniel Marchetti, Gerard J Criner, Ella A Kazerooni, Eric A Hoffman, Brian D Ross, Craig J Galban, Christine T Cigolle, Fernando J Martinez, MeiLan K Han
RATIONALE: Aging is associated with reduced forced expiratory volume in the first second (FEV1) to forced vital capacity (FVC) ratio (FEV1/FVC), hyperinflation and alveolar enlargement, but little is known about how age affects small airways. We hypothesized that chest computed tomography(CT)-assessed functional small airway would increase with age, even among asymptomatic individuals. METHODS: We used parametric response mapping analysis of paired inspiratory/expiratory CTs to identify functional small airway abnormality (PRMFSA) and emphysema (PRMEMPH) in the SPIROMICS cohort...
August 26, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27541698/variation-in-us-outpatient-antibiotic-prescribing-quality-measures-according-to-health-plan-and-geography
#16
Rebecca M Roberts, Lauri A Hicks, Monina Bartoces
OBJECTIVES: Antibiotic prescribing has become increasingly viewed as an issue related to patient safety and quality of care. The objective of this study was to better understand the differences between health plan reporting and the geographic variation seen in quality measures related to antibiotic use. STUDY DESIGN: We focused on 3 measures from the Healthcare Effectiveness Data and Information Set (HEDIS) related to antibiotic prescribing and testing to guide antibiotic prescribing...
August 2016: American Journal of Managed Care
https://www.readbyqxmd.com/read/27510377/signal-detection-of-adverse-drug-reaction-of-amoxicillin-using-the-korea-adverse-event-reporting-system-database
#17
Mick Soukavong, Jungmee Kim, Kyounghoon Park, Bo Ram Yang, Joongyub Lee, Xue Mei Jin, Byung Joo Park
We conducted pharmacovigilance data mining for a β-lactam antibiotics, amoxicillin, and compare the adverse events (AEs) with the drug labels of 9 countries including Korea, USA, UK, Japan, Germany, Swiss, Italy, France, and Laos. We used the Korea Adverse Event Reporting System (KAERS) database, a nationwide database of AE reports, between December 1988 and June 2014. Frequentist and Bayesian methods were used to calculate disproportionality distribution of drug-AE pairs. The AE which was detected by all the three indices of proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC) was defined as a signal...
September 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27492531/the-effect-of-n-acetylcysteine-on-biofilms-implications-for-the-treatment-of-respiratory-tract-infections
#18
REVIEW
Francesco Blasi, Clive Page, Gian Maria Rossolini, Lucia Pallecchi, Maria Gabriella Matera, Paola Rogliani, Mario Cazzola
OBJECTIVES: In airway infections, biofilm formation has been demonstrated to be responsible for both acute and chronic events, and constitutes a genuine challenge in clinical practice. Difficulty in eradicating biofilms with systemic antibiotics has led clinicians to consider the possible role of non-antibiotic therapy. The aim of this review is to examine current evidence for the use of N-acetylcysteine (NAC) in the treatment of biofilm-related respiratory infections. METHODS: Electronic searches of PUBMED up to September 2015 were conducted, searching for 'biofilm', 'respiratory tract infection', 'N-acetylcysteine', 'cystic fibrosis', 'COPD', 'bronchiectasis', 'otitis', and 'bronchitis' in titles and abstracts...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27267983/changing-the-antibiotic-prescribing-of-general-practice-registrars-the-chap-study-protocol-for-a-prospective-controlled-study-of-a-multimodal-educational-intervention
#19
Mieke L van Driel, Simon Morgan, Amanda Tapley, Lawrie McArthur, Patrick McElduff, Lucy Yardley, Anthea Dallas, Laura Deckx, Katie Mulquiney, Joshua S Davis, Andrew Davey, Kim Henderson, Paul Little, Parker J Magin
BACKGROUND: Australian General Practitioners (GPs) are generous prescribers of antibiotics, prompting concerns including increasing antimicrobial resistance in the community. Recent data show that GPs in vocational training have prescribing patterns comparable with the high prescribing rate of their established GP supervisors. Evidence-based guidelines consistently advise that antibiotics are not indicated for uncomplicated upper respiratory tract infections (URTI) and are rarely indicated for acute bronchitis...
2016: BMC Family Practice
https://www.readbyqxmd.com/read/27255566/evaluation-of-aloe-vera-and-synbiotic-as-antibiotic-growth-promoter-substitutions-on-performance-gut-morphology-immune-responses-and-blood-constitutes-of-broiler-chickens
#20
Ali Naghi Shokri, Hossein A Ghasemi, Kamran Taherpour
This study was performed to investigate the effect of dietary supplementation with Aloe vera (AV) powder and synbiotic as growth promoter agents on performance, gut morphology, immune responses, hematology and serum biochemistry in broilers. A total of 240-day-old male broiler chicks (Ross 308) were randomly assigned to six treatments with four replicates. Birds were offered either a corn-soybean meal basal diet (control) or the basal diet supplemented with 200 mg/kg virginiamycin (VM), 1 g/kg synbiotic (Syn), 2...
June 3, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
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