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Myocardial infarction utilization

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https://www.readbyqxmd.com/read/28435004/improvements-in-left-ventricular-diastolic-mechanics-after-parachute-device-implantation-in-patients-with-ischemia-heart-failure-a-cardiac-ct-study
#1
Chun-Ho Yun, Jing-Yi Sun, Barry Templin, Shih-Hsuan Lin, Kuan-Ming Chen, Tung-Hsin Wu, Chung-Lieh Hung, Chun-Chieh Liu, Hsi-Hsien Hsu, Mohamad Amer Alaiti, Anas Fares, Anthony DeCicco, Hiram G Bezerra
BACKGROUND: Percutaneous ventricular restoration therapy using left ventricle (LV) partitioning Parachute device has emerged as a clinical treatment option for LV apical aneurysm post extensive anterior myocardial infarction (AMI). We assessed changes of diastolic mechanics and accompanied functional improvements following LV parachute device implantation by cardiac computed tomography (CCT). METHODS AND RESULTS: CCT data from 28 patients in the pre- and post-implantation of LV parachute device implantation...
April 20, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28433337/increased-resource-utilization-and-overall-morbidity-are-associated-with-general-versus-regional-anesthesia-for-carotid-endarterectomy-in-data-collected-by-the-michigan-surgical-quality-collaborative
#2
Ahmad S Hussain, Andrew Mullard, William F Oppat, Kevin D Nolan
OBJECTIVE: Advocates for performing carotid endarterectomy (CEA) under regional anesthesia (RA) cite reduction in hemodynamic instability and the ability for neurologic monitoring, but many still prefer general anesthesia (GA) as benefits of RA have not been clearly demonstrated, reliable RA may not be available in all centers, and a certain amount of movement by the patient during the procedure may not be uniformly tolerated. We evaluated the association of anesthesia type and perioperative morbidity and mortality as well as resource utilization in patients undergoing CEA using the Michigan Surgical Quality Collaborative (MSQC) database...
April 19, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28421305/the-utility-of-global-longitudinal-strain-in-the-identification-of-prior-myocardial-infarction-in-patients-with-preserved-left-ventricular-ejection-fraction
#3
Graham J Fent, Pankaj Garg, James R J Foley, Laura E Dobson, Tarique A Musa, Bara Erhayiem, John P Greenwood, Sven Plein, Peter P Swoboda
Prior myocardial infarction (MI) is associated with increased mortality and is prevalent in certain high risk patient groups. Electrocardiogram may be used in diagnosis, however, sensitivity is limited, thus non-invasive imaging techniques may improve diagnosis. We investigated whether global longitudinal strain (GLS) and longitudinal strain parameters are reduced in patients with prior MI but preserved left ventricular ejection fraction (LVEF). The study included 40 clinical patients with prior MI occurring >3 months previously (defined as subendocardial hyperenhancement on late Gadolinium enhancement imaging) with LVEF ≥ 55% and 40 controls matched for age and LVEF...
April 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28419280/fractional-flow-reserve-and-pressure-bounded-coronary-flow-reserve-to-predict-outcomes-in-coronary-artery-disease
#4
Jung-Min Ahn, Frederik M Zimmermann, Nils P Johnson, Eun-Seok Shin, Bon-Kwon Koo, Pil Hyung Lee, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Nico H J Pijls, Seung-Jung Park
Aims: Fractional flow reserve (FFR) has proven to its prognostic and therapeutic value. However, the additive prognostic value of coronary flow reserve (CFR) remains unclear. This study sought to investigate the clinical utility of combined FFR and CFR measurements to predict outcomes. Methods and results: Using the prospective, multicentre Interventional Cardiology Research Incooperation Society-FFR registry, a total of 2088 lesions from 1837 patients were included in this substudy...
April 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28414761/identification-of-a-plasma-metabolomic-signature-of-thrombotic-myocardial-infarction-that-is-distinct-from-non-thrombotic-myocardial-infarction-and-stable-coronary-artery-disease
#5
Andrew P DeFilippis, Patrick J Trainor, Bradford G Hill, Alok R Amraotkar, Shesh N Rai, Glenn A Hirsch, Eric C Rouchka, Aruni Bhatnagar
AIMS: Current non-invasive diagnostics for acute myocardial infarction (MI) identify myocardial necrosis rather than the primary cause and therapeutic target-plaque disruption and resultant thrombosis. The aim of this study was to identify changes specific to plaque disruption and pathological thrombosis that are distinct from acute myocardial necrosis. METHODS AND RESULTS: We quantified 1,032 plasma metabolites by mass spectrometry in 11 thrombotic MI, 12 non-thrombotic MI, and 15 stable coronary artery disease (CAD) subjects at two acute phase (time of catheterization [T0], six hours [T6]) and one quiescent (>3 months follow-up) time points...
2017: PloS One
https://www.readbyqxmd.com/read/28409655/9-1-1-triage-of-non-traumatic-chest-pain-association-with-hospital-diagnosis
#6
Greg Scott, Jeff J Clawson, Isabel Gardett, Meghan Broadbent, Nathan Williams, Conrad Fivaz, Gigi Marshall, Tracey Barron, Christopher Olola
OBJECTIVE: Chest pain is one of the most common reasons people seek emergency care-and one of the most critical. In the United States, chest pain is the second most common reason for emergency department (ED) visits. A patient's primary complaint of "chest pain" may reflect a broad range of underlying causes; therefore, it is important that emergency medical service (EMS) agencies gain a thorough understanding of these cases, beginning with the initial management of chest pain in the 9-1-1 center...
April 14, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28406123/utilization-of-glial-fibrillary-acidic-protein-and-galectin-3-in-the-diagnosis-of-cerebral-infarction-patients-with-normal-cranial-tomography
#7
E Ekingen, M Yilmaz, M Yildiz, M Atescelik, M C Goktekin, M Gurger, O D Alatas, M Basturk, N Ilhan
OBJECTIVE: It was aimed to determine whether levels of glial fibrillary acidic protein (GFAP) and Galectin-3 contribute to the diagnosis of cerebral infarction in clinically suspected ischemic stroke patients with normal computerized cranial tomography (CCT) in the emergency department. MATERIALS AND METHODS: In this study, patients above the age of 18 years who presented to emergency department of Firat University between December 2011-November 2012 and were diagnosed with cerebral infarction were included...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28404934/increased-serum-resistin-level-is-associated-with-coronary-heart-disease
#8
Jing-Zhan Zhang, Ying Gao, Ying-Ying Zheng, Fen Liu, Yi-Ning Yang, Xiao-Mei Li, Xiang Ma, Yi-Tong Ma, Xiang Xie
To explore the relationship between the serum resistin level and different types of coronary heart diseases (CHD). Literature was retrieved by formal searching of PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, China Biological Medicine Database (SinoMed) and China National Knowledge Infrastructure (CNKI) and by hand searching of reference lists of related articles. RevMan5.3 statistical software was utilized for processing and analysis. A total of 22 literatures involving 2070 subjects were included...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404560/statin-eligibility-and-outpatient-care-prior-to-st-segment-elevation-myocardial-infarction
#9
Michael D Miedema, Ross F Garberich, Lucas J Schnaidt, Erin Peterson, Craig Strauss, Scott Sharkey, Thomas Knickelbine, Marc C Newell, Timothy D Henry
BACKGROUND: The impact of the 2013 American College of Cardiology/American Heart Association cholesterol guidelines on statin eligibility in individuals otherwise destined to experience cardiovascular disease (CVD) events is unclear. METHODS AND RESULTS: We analyzed a prospective cohort of consecutive ST-segment elevation myocardial infarction (STEMI) patients from a regional STEMI system with data on patient demographics, low-density lipoprotein cholesterol levels, CVD risk factors, medication use, and outpatient visits over the 2 years prior to STEMI...
April 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28404227/multivessel-stent-thrombosis-with-optical-coherence-tomography-oct-utilization-for-therapeutic-guidance
#10
Neil Yager, Arjun Majithia, Sergio Waxman
A 63 year old male presents with anterior ST elevation myocardial infarction. Two years prior he had PCI with DES to the proximal left anterior descending (LAD) and circumflex arteries following an abnormal stress test. Clopidogrel was discontinued several weeks prior to this presentation.
March 31, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28400941/abnormal-color-flow-signal-traversing-the-myocardial-wall-not-everything-is-what-it-appears-to-be
#11
Kathy Edelman, Angel López-Candales
A case of a patient presenting with an acute myocardial infarction is presented. A transthoracic echocardiographic examination revealed an abnormal color flow signal that traversed the myocardial wall from a large inferior aneurysm and initially considered to be a ventricular septal defect. However, further echocardiographic manipulation utilizing modified views along with sequential injections of both agitated saline and Definity(®) proved very useful to identify a pseudoaneurysm. There was no further need for any other diagnostic test, and the patient was treated surgically, undergoing successful repair of the pseudoaneurysm as well as coronary artery bypass grafting of the left coronary artery...
October 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28395884/comparison-of-clinical-characteristics-and-outcomes-of-patients-with-versus-without-diabetes-mellitus-and-with-versus-without-angina-pectoris-from-the-duke-databank-for-cardiovascular-disease
#12
Adam Banks, Samuel Broderick, Karen Chiswell, Linda Shaw, Adam Devore, Mona Fiuzat, Christopher O'Connor, Gary Michael Felker, Eric Velazquez, Robert Mentz
Angina pectoris (AP) has different prognostic implications in various populations. Patients with diabetes mellitus (DM) may experience neuropathy such that AP may not be perceived in the setting of coronary artery disease (CAD). The prognostic utility of AP in DM patients with CAD is not well known. We analyzed patients with CAD who underwent coronary angiography at Duke University from 2002 to 2011 and compared patients with and without AP within the previous 6 weeks stratified by DM status. We used multivariable Cox regression to assess the association between AP and the outcomes of cardiovascular (CV) hospitalization/revascularization, all-cause mortality/myocardial infarction/revascularization, and all-cause mortality...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28387143/diabetes-control-incidence-of-acute-myocardial-infarction-and-all-cause-mortality-among-patients-with-3-6-years-disease-duration
#13
Orna Reges, Morton Leibowitz, Moshe Hoshen, Maya Leventer-Roberts, Philip Greenland, Ran Balicer
Background Optimal glycated haemoglobin (HbA1c) concentrations to minimize large vessel complications and prolong life in diabetes patients are not well established. Design A retrospective cohort study from 2010 to 2012 using data from the Clalit Health Service (Clalit) integrated healthcare system's electronic data warehouse. Patients included had newly incident diabetes, had at least two HbA1c measurements during the 3 years prior to 1 January 2010 without any disruption(s) in Clalit membership between 2010 and 2014...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28385357/the-adjusted-global-antiphospholipid-syndrome-score-agapss-for-risk-stratification-in-young-aps-patients-with-acute-myocardial-infarction
#14
M Radin, K Schreiber, P Costanzo, I Cecchi, D Roccatello, S Baldovino, M Bazzan, M J Cuadrado, S Sciascia
BACKGROUND: Young adults with acute myocardial infarction are a critical group to examine for the purpose of risk factor stratification and modification. In this study we aimed to assess the clinical utility of the adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) for the risk stratification of acute myocardial infarction in a cohort of young patients with antiphospholipid syndrome (APS). METHODS: The analysis included 83 consecutive APS patients (≤50years old) who presented with arterial or venous thromboembolic events...
March 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28382156/theranostic-nucleic-acid-binding-nanoprobe-exerts-anti-inflammatory-and-cytoprotective-effects-in-ischemic-injury
#15
Howard H Chen, Hushan Yuan, Hoonsung Cho, Yan Feng, Soeun Ngoy, Anand T N Kumar, Ronglih Liao, Wei Chao, Lee Josephson, David E Sosnovik
Extracellular nucleic acids are proinflammatory molecules that have been implicated in a diverse range of diseases. We report here the development of a multivalent nucleic acid scavenging nanoprobe, where the fluorochrome thiazole orange (TO) is conjugated to a polymeric 40 kDa dextran carrier. Dextran-TO (Dex-TO) has nanomolar affinity for mammalian and bacterial nucleic acids and attenuates the production of inflammatory cytokines from activated macrophages exposed to DNA and RNA. Mice with myocardial ischemia reperfusion that were treated with Dex-TO showed a decrease in myocardial macrophage infiltration at 24 hours (p<0...
2017: Theranostics
https://www.readbyqxmd.com/read/28371309/comprehensive-metabonomic-analysis-of-heart-tissue-from-isoproterenol-induced-myocardial-infarction-rat-based-on-reversed-phase-and-hydrophilic-interaction-chromatography-coupled-to-mass-spectrometry
#16
Lei Sun, Jianxun Liu, Mingqian Sun, Li Lin, Lan Miao, Zhengyan Ge, Bin Yang
We aim to describe the metabonomic characteristics of myocardial infarction rats. High-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was utilized to develop a metabonomic method of the heart homogenates of myocardial infarction rats. Hydrophilic interaction chromatography allows the analysis of high polar metabolites, providing complementary information to reversed-phase liquid chromatography. We combined reversed phase and hydrophilic interaction chromatographic separations to analyze 18 samples, ten from myocardial infarction rat hearts and eight from normal rat hearts...
March 29, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28366473/correlation-of-corrected-qt-interval-with-quantitative-cardiac-troponin-i-levels-and-its-prognostic-role-in-non-st-elevation-myocardial-infarction
#17
Satyam Rajvanshi, Ranjit Nath, Manoj Kumar, Ankit Gupta, Neeraj Pandit
BACKGROUND: Non-ST-elevation Myocardial Infarction (NSTEMI) subgroup of ACS has wide variability in patient prognosis. Risk stratification in NSTE-ACS is essential for deciding about early management. Corrected QT interval estimation is one tool which has utility in bedside risk stratification. Whether it differentiates NSTEMI patients into different risk groups is the contention of this study. OBJECTIVE: To assess (1) correlation between maximum corrected QT interval (QTc) and cardiac Troponin I (cTnI) levels; (2) if prolonged corrected QT interval is an independent predictor of higher MACE in NSTEMI patients...
March 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28366472/mice-or-nice-an-economic-evaluation-of-clinical-decision-rules-in-the-diagnosis-of-heart-failure-in-primary-care
#18
Mark Monahan, Pelham Barton, Clare J Taylor, Andrea K Roalfe, F D Richard Hobbs, Martin Cowie, Russell Davis, Jon Deeks, Jonathan Mant, Deborah McCahon, Theresa McDonagh, George Sutton, Lynda Tait
BACKGROUND: Detection and treatment of heart failure (HF) can improve quality of life and reduce premature mortality. However, symptoms such as breathlessness are common in primary care, have a variety of causes and not all patients require cardiac imaging. In systems where healthcare resources are limited, ensuring those patients who are likely to have HF undergo appropriate and timely investigation is vital. DESIGN: A decision tree was developed to assess the cost-effectiveness of using the MICE (Male, Infarction, Crepitations, Edema) decision rule compared to other diagnostic strategies to identify HF patients presenting to primary care...
March 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28364777/in-vivo-mri-and-ex-vivo-histological-assessment-of-the-cardioprotection-induced-by-ischemic-preconditioning-postconditioning-and-remote-conditioning-in-a-closed-chest-porcine-model-of-reperfused-acute-myocardial-infarction-importance-of-microvasculature
#19
Tamás Baranyai, Zoltán Giricz, Zoltán V Varga, Gábor Koncsos, Dominika Lukovic, András Makkos, Márta Sárközy, Noémi Pávó, András Jakab, Csilla Czimbalmos, Hajnalka Vágó, Zoltán Ruzsa, Levente Tóth, Rita Garamvölgyi, Béla Merkely, Rainer Schulz, Mariann Gyöngyösi, Péter Ferdinandy
BACKGROUND: Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies and clinical trials utilize necrotic tissue referred to the area at risk (AAR) by magnetic resonance imaging (MRI). However, determination of AAR by MRI' may not be accurate, since MRI-indices of microvascular damage, i.e., myocardial edema and microvascular obstruction (MVO), may be affected by cardioprotection independently from myocardial necrosis...
April 1, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28364393/lipid-emulsion-enhances-cardiac-performance-after-ischemia-reperfusion-in-isolated-hearts-from-summer-active-arctic-ground-squirrels
#20
Michele M Salzman, Qunli Cheng, Richard J Deklotz, Gurpreet K Dulai, Hunter F Douglas, Anna E Dikalova, Dorothee Weihrauch, Brian M Barnes, Matthias L Riess
Hibernating mammals, like the arctic ground squirrel (AGS), exhibit robust resistance to myocardial ischemia/reperfusion (IR) injury. Regulated preference for lipid over glucose to fuel metabolism may play an important role. We tested whether providing lipid in an emulsion protects hearts from summer-active AGS better than hearts from Brown Norway (BN) rats against normothermic IR injury. Langendorff-prepared AGS and BN rat hearts were perfused with Krebs solution containing 7.5 mM glucose with or without 1% Intralipid™...
March 31, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
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