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Myocardial infarction utilization

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https://www.readbyqxmd.com/read/29778317/appropriate-use-of-noninvasive-ischemia-testing-to-guide-revascularization-decision-making-following-acute-st-elevation-myocardial-infarction-in-latin-american-countries-results-from-an-expert-panel-meeting-of-the-international-atomic-energy-agency
#1
I Berrocal, A Peix, F Mut, L J Shaw, G Karthikeyan, E Estrada Lobato, D Paez
Across Latin American and Caribbean countries, cardiovascular disease and especially ischemic heart disease is currently the main cause of death both in men and in women. For most Latin American and Caribbean countries, public and community health efforts aim to define care strategies which are both clinically and cost effective and promote primary and secondary prevention, resulting in improved patient outcomes. The optimal approach to deal with acute events such as ST-elevation myocardial infarction (STEMI) is a matter of controversy; however, there is an expanding role for assessing residual ischemic burden in STEMI patients following primary percutaneous coronary intervention...
May 16, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29775405/the-mouse-heart-attack-research-tool-mhart-1-0-database
#2
Kristine Y DeLeon-Pennell, Rugmani Padmanabhan Iyer, Yonggang Ma, Andriy Yabluchanskiy, Rogelio Zamilpa, Ying Ann Chiao, Presley Cannon, Courtney Cates, Elizabeth R Flynn, Ganesh V Halade, Lisandra E de Castro Bras, Merry L Lindsey
The generation of Big Data has enabled systems-level dissections into the mechanisms of cardiovascular pathology. Integration of genetic, proteomic, and pathophysiological variables across platforms and laboratories fosters discoveries through multidisciplinary investigations and minimizes unnecessary redundancy in research efforts. The Mouse Heart Attack Research Tool (mHART) consolidates a large dataset of over 10 years of experiments from a single laboratory for cardiovascular investigators to generate novel hypotheses and identify new predictive markers of progressive left ventricular remodeling following myocardial infarction (MI) in mice...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29765432/utility-and-safety-of-three-dimensional-contrast-low-dose-dobutamine-echocardiography-in-the-evaluation-of-myocardial-viability-early-after-an-acute-myocardial-infarction
#3
Piotr Scisło, Janusz Kochanowski, Łukasz Kołtowski, Grzegorz Opolski
Introduction: The aim of the study was to determine the utility and safety of three-dimensional contrast low-dose dobutamine echocardiography (3DCLDDE) in the evaluation of myocardial viability early after ST-elevation myocardial infarction (STEMI). Material and methods: We prospectively evaluated a group of 100 consecutive patients. Myocardial viability was assessed using dobutamine echocardiography in 76 patients with segmental wall motion abnormalities, including 37 patients evaluated using 3DCLDDE and 39 patients evaluated using a standard low-dose dobutamine echocardiography protocol (LDDE), alternately...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764713/utility-of-grace-and-acuity-horizons-risk-scores-to-guide-dual-antiplatelet-therapy-in-korean-patients-with-acute-myocardial-infarction-undergoing-drug-eluting-stenting
#4
Doo Sun Sim, Myung Ho Jeong, Hyo Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jong Sun Park, Jung Han Yoon, Jei Keon Chae, Seung Jae Joo, Dong Ju Choi, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Doo Il Kim, Seok Kyu Oh, Tae Hoon Ahn, Jin Yong Hwang
BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended in patients receiving drug-eluting stents (DES). However, bleeding risk should be weighed against ischemic risk. Utility of GRACE risk score and ACUITY-HORIZONS bleeding risk score was assessed in patients with acute myocardial infarction (MI) according to use of P2Y12 blocker. METHODS: From the Korea Acute Myocardial Infarction Registry-National Institute of Health database, 7791 patients with acute MI receiving DES were divided into ticagrelor (n=1554) and clopidogrel (n=6237) groups...
May 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29760740/current-progress-in-the-rejuvenation-of-aging-stem-progenitor-cells-for-improving-the-therapeutic-effectiveness-of-myocardial-repair
#5
REVIEW
Gurleen Kaur, Chuanxi Cai
Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenation is required to reverse the damage levied by aging and promote a youthful phenotype. This review aims to discuss current strategies that are effective in rejuvenating aging cardiac stem cells and represent novel therapeutic methods to treat the aging heart...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29759535/utility-of-conventional-electrocardiographic-criteria-in-patients-with-idiopathic-ventricular-tachycardia
#6
Anil V Yadav, Babak Nazer, Barbara J Drew, John M Miller, Hicham El Masry, William J Groh, Andrea Natale, Nassir Marrouche, Nitish Badhwar, Yanfei Yang, Melvin M Scheinman
OBJECTIVES: This study sought to determine the ability of conventional electrocardiographic (ECG) criteria to correctly differentiate idiopathic ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy. BACKGROUND: Previously reported VT ECG criteria were developed from cohorts of patients with structural heart disease and have not been applied to patients with idiopathic VT. METHODS: ECGs of 115 idiopathic VTs, 101 post-myocardial infarction (MI) VTs, and 111 wide QRS SVTs were analyzed using standard criteria...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29753765/maximization-of-the-usage-of-coronary-cta-derived-plaque-information-using-a-machine-learning-based-algorithm-to-improve-risk-stratification-insights-from-the-confirm-registry
#7
Alexander R van Rosendael, Gabriel Maliakal, Kranthi K Kolli, Ashley Beecy, Subhi J Al'Aref, Aeshita Dwivedi, Gurpreet Singh, Mohit Panday, Amit Kumar, Xiaoyue Ma, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Jeroen J Bax, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, Heidi Gransar, Yao Lu, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min
INTRODUCTION: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. METHODS: From the multi-center CONFIRM registry, patients were included with complete CCTA risk score information and ≥3 year follow-up for myocardial infarction and death (primary endpoint)...
April 30, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29750994/regulation-of-cardiac-fibroblast-mmp2-gene-expression-by-scleraxis
#8
Raghu S Nagalingam, Hamza A Safi, Danah S Al-Hattab, Rushita A Bagchi, Natalie M Landry, Ian M C Dixon, Jeffrey T Wigle, Michael P Czubryt
Remodeling of the cardiac extracellular matrix is responsible for a number of the detrimental effects on heart function that arise secondary to hypertension, diabetes and myocardial infarction. This remodeling consists both of an increase in new matrix protein synthesis, and an increase in the expression of matrix metalloproteinases (MMPs) that degrade existing matrix structures. Previous studies utilizing knockout mice have demonstrated clearly that MMP2 plays a pathogenic role during matrix remodeling, thus it is important to understand the mechanisms that regulate MMP2 gene expression...
May 8, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29748060/haemodynamically-derived-pulmonary-artery-pulsatility-index-predicts-mortality-in-pulmonary-arterial-hypertension
#9
Sula Mazimba, Timothy S Welch, Hunter Mwansa, Khadijah K Breathett, Jamie L W Kennedy, Andrew D Mihalek, William C Harding, Manu M Mysore, David X Zhuo, Kenneth C Bilchick
BACKGROUND: Pulmonary artery (PA) pulsitility index (PAPi) is a novel haemodynamic index shown to predict right ventricular failure in acute inferior myocardial infarction and post left ventricular assist device surgery. We hypothesised that PAPi calculated as [PA systolic pressure - PA diastolic pressure]/right atrial pressure (RAP) would be associated with mortality in the National Institutes of Health Registry for Primary Pulmonary Hypertension (NIH-RPPH). METHODS: The impact of PAPi, the Pulmonary Hypertension Connection (PHC) risk score, right ventricular stroke work, pulmonary artery capacitance (PAC), other haemodynamic indices, and demographic characteristics was evaluated in 272 NIH-RPPH patients using multivariable Cox proportional hazards (CPH) regression and receiver operating characteristic (ROC) analysis...
April 17, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29744618/association-between-central-venous-pressure-as-assessed-by-echocardiography-left-ventricular-function-and-acute-cardio-renal-syndrome-in-patients-with-st-segment-elevation-myocardial-infarction
#10
Shafik Khoury, Arie Steinvil, Amir Gal-Oz, Gilad Margolis, Aviram Hochstatd, Yan Topilsky, Gad Keren, Yacov Shacham
BACKGROUND: Recent reports have demonstrated the adverse effects of venous congestion on renal function in patients with heart failure. None of these trials, however, has evaluated the effect of acute myocardial ischemia on the occurrence of acute kidney injury (AKI). METHODS: We conducted a retrospective study of 1336 ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) between June 2012 and June 2016...
May 9, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29739799/healthcare-utilization-and-statin-re-initiation-among-medicare-beneficiaries-with-a-history-of-myocardial-infarction
#11
John N Booth, Lisandro D Colantonio, Robert S Rosenson, Monika M Safford, Ligong Chen, Meredith L Kilgore, Todd M Brown, Benjamin Taylor, Ricardo Dent, Keri L Monda, Paul Muntner, Emily B Levitan
BACKGROUND: Contact with the healthcare system represents an opportunity for individuals who discontinue statins to re-initiate treatment. To help identify opportunities for healthcare providers to emphasize the risk-lowering benefits accrued through restarting statins, we determined the types of healthcare utilization associated with statin re-initiation among patients with history of a myocardial infarction. METHODS AND RESULTS: Medicare beneficiaries with a statin pharmacy fill claim within 30 days of hospital discharge for a myocardial infarction in 2007 to 2012 (n=158 795) were followed for 182 days postdischarge to identify treatment discontinuation, defined as 60 continuous days without statins (n=24 461)...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29739432/emergency-management-of-patients-with-st-segment-elevation-myocardial-infarction-in-eastern-austria-a-descriptive-quality-control-study
#12
Helmut Trimmel, Thomas Bayer, Wolfgang Schreiber, Wolfgang G Voelckel, Lukas Fiedler
BACKGROUND: Myocardial infarction is a time-critical condition and its outcome is determined by appropriate emergency care. Thus we assessed the efficacy of a supra-regional ST-segment elevation myocardial infarction (STEMI) network in Easternern Austria. METHODS: The Eastern Austrian STEMI network serves a population of approx. 766.000 inhabitants within a region of 4186 km2 . Established in 2007, it now comprises 20 pre-hospital emergency medical service (EMS) units (10 of these physician-staffed), 4 hospitals and 3 cardiac intervention centres...
May 9, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29738370/biologics-and-cardiovascular-disease
#13
John S Van Taunay, M Teresa Albelda, Juan Carlos Frias, Michael J Lipinski
The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations. Atherosclerosis, myocardial infarction, and heart failure have been closely linked to the inflammatory response. Accordingly, cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 have been targeted...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29736894/smoking-cessation-a-comparison-of-two-model-structures
#14
Becky Pennington, Alex Filby, Lesley Owen, Matthew Taylor
BACKGROUND: Most economic evaluations of smoking cessation interventions have used cohort state-transition models. Discrete event simulations (DESs) have been proposed as a superior approach. OBJECTIVE: We developed a state-transition model and a DES using the discretely integrated condition event (DICE) framework and compared the cost-effectiveness results. We performed scenario analysis using the DES to explore the impact of alternative assumptions. METHODS: The models estimated the costs and quality-adjusted life years (QALYs) for the intervention and comparator from the perspective of the UK National Health Service and Personal Social Services over a lifetime horizon...
May 8, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29731350/the-cost-effectiveness-of-pcsk9-inhibitors-the-australian-healthcare-perspective
#15
Radya Kumar, Andrew Tonkin, Danny Liew, Ella Zomer
BACKGROUND: For patients in whom statins are not tolerated or effective as monotherapy, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid lowering therapies that may reduce low-density lipoprotein cholesterol (LDL-C) levels by up to 50% and lower cardiovascular events. While an important treatment option, the cost-effectiveness of PCSK9i in Australia remains unknown. This study aimed to determine the cost-effectiveness of PCSK9i compared to placebo in the prevention of atherosclerotic cardiovascular disease (CVD)...
April 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29719939/psoriasis-and-risk-of-myocardial-infarction-before-and-during-an-era-with-biological-therapy-a-population-based-follow-up-study
#16
M Z Leisner, J Lindorff Riis, R Gniadecki, L Iversen, M Olsen
BACKGROUND: Attention towards cardiovascular disease prevention in patients with moderate to severe psoriasis increased with the introduction of biological therapy. OBJECTIVE: To determine the risk of myocardial infarction (MI) following hospital diagnosed psoriasis compared with the general population, in eras before and following the introduction of biological therapy. METHODS: We conducted a cohort study in Denmark utilizing nationwide prospectively collected data from population-based registries...
May 2, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29719035/single-center-retrospective-study-of-risk-factors-and-predictive-value-of-framingham-risk-score-of-patients-with-st-elevation-myocardial-infarction
#17
Sohail Ikram, Ajay Pachika, Henrike Schuster, Aman Ghotra, Laura Dotson, Shoaib Akbar, Abdur Rahman Khan
OBJECTIVES: The objective of this study was to identify risk factors and clinical profile of the patients presenting with ST elevation myocardial infarction (STEMI). We further evaluated the utility of the Framingham Risk Score (FRS) in the accurate identification of these patients if used before their coronary event. METHODS: We evaluated the demographic, clinical, and angiographic characteristics of patients admitted with STEMI. We also calculated cardiovascular event risk using the FRS in a subset of patients without prior known coronary artery disease and diabetes mellitus...
April 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29717509/impact-of-delirium-on-patients-hospitalized-for-myocardial-infarction-a-propensity-score-analysis-of-the-national-inpatient-sample
#18
Abdullah Abdullah, George Eigbire, Amr Salama, Abdul Wahab, Mohanad Awadalla, Ryan Hoefen, Richard Alweis
BACKGROUND: Delirium is associated with worse outcomes in critically ill patients. In the subset of patients with myocardial infarction (MI), the impact on clinical outcomes of delirium is not as well elucidated. HYPOTHESIS: Delirium is associated with increased mortality in patients hospitalized for MI METHODS: The study used data from the National Inpatient Sample (NIS) 2012 - 2014, Healthcare Cost and Utilization Project (HCUP). We included discharges associated with the primary diagnosis of MI using the relevant ICD-9-CM codes...
May 1, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29717283/utility-of-ischemia-modified-albumin-as-an-early-marker-for-diagnosis-of-acute-coronary-syndrome
#19
Bijaya Mishra, Sunil Pandey, Surya Raj Niraula, Bijendra Kumar Rai, Prahlad Karki, Nirmal Baral, Madhab Lamsal
BACKGROUND: The diagnosis of acute coronary syndrome remains challenging, as cardiac troponins and creatine kinase-MB do not detect myocardial ischemia. Ischemia modified albumin is biomarker positive within 6-10 minutes following ischemic onset, where oxygen free radicals leads to reduction in binding capacity of human serum albumin to transitional metal-cobalt. The objective of this study was to compare ischemia modified albumin between acute coronary syndrome patients and healthy controls, and evaluate diagnostic performance of ischemia modified albumin compared to cardiac troponins, creatine kinase-MB and electrocardiogram in acute coronary syndrome patients...
March 13, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29716810/long-term-follow-up-of-total-arterial-versus-conventional-and-hybrid-myocardial-revascularization-a-propensity-score-matched-analysis
#20
Lorenzo Di Bacco, Alberto Repossini, Maurizio Tespili, Claudio Muneretto, Gianluigi Bisleri
PURPOSE: To evaluate the impact of the revascularization technique (by means of conventional, total arterial or hybrid myocardial revascularization) in patients with multivessel coronary artery disease. METHODS: A propensity-score analysis of patients undergoing myocardial revascularization from 1998 to 2012 was performed based on the surgical technique utilized, either total arterial (Group1, G1,n° = 89), conventional CABG(LIMA on LAD plus veins, Group2, G2,n° = 89), or hybrid revascularization (LIMA on LAD plus PTCA on non-LAD vessels, Group3, G3, n° = 89)...
April 13, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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